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Tania J. Lupoli, Ph.D. - Publications

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics
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24/33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Harnagel AP, Sheshova M, Zheng M, Zheng M, Skorupinska-Tudek K, Swiezewska E, Lupoli TJ. Preference of Bacterial Rhamnosyltransferases for 6-Deoxysugars Reveals a Strategy To Deplete O-Antigens. Journal of the American Chemical Society. 145: 15639-15646. PMID 37437030 DOI: 10.1021/jacs.3c03005  0.351
2023 Zheng M, Zheng MC, Kim H, Lupoli TJ. Feedback Inhibition of Bacterial Nucleotidyltransferases by Rare Nucleotide l-Sugars Restricts Substrate Promiscuity. Journal of the American Chemical Society. PMID 37283497 DOI: 10.1021/jacs.3c02319  0.604
2022 Zheng M, Zheng M, Lupoli TJ. Expanding the Substrate Scope of a Bacterial Nucleotidyltransferase via Allosteric Mutations. Acs Infectious Diseases. PMID 36106727 DOI: 10.1021/acsinfecdis.2c00402  0.598
2022 Nelson B, Hong SH, Lupoli TJ. Protein Cofactor Mimics Disrupt Essential Chaperone Function in Stressed Mycobacteria. Acs Infectious Diseases. 8: 901-910. PMID 35412813 DOI: 10.1021/acsinfecdis.1c00651  0.305
2021 Hosfelt J, Richards A, Zheng M, Adura C, Nelson B, Yang A, Fay A, Resager W, Ueberheide B, Glickman JF, Lupoli TJ. An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance. Cell Chemical Biology. PMID 34818532 DOI: 10.1016/j.chembiol.2021.11.004  0.59
2021 Zheng M, Zheng M, Epstein S, Harnagel AP, Kim H, Lupoli TJ. Chemical Biology Tools for Modulating and Visualizing Gram-Negative Bacterial Surface Polysaccharides. Acs Chemical Biology. PMID 34569792 DOI: 10.1021/acschembio.1c00341  0.556
2021 Zheng M, Lupoli TJ. Modulation of a Mycobacterial ADP-Ribosyltransferase to Augment Rifamycin Antibiotic Resistance. Acs Infectious Diseases. PMID 34355905 DOI: 10.1021/acsinfecdis.1c00297  0.568
2020 Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet JE, Arthur M, Sacchettini JC, et al. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. Frontiers in Microbiology. 11: 1248. PMID 32655524 DOI: 10.3389/Fmicb.2020.01248  0.363
2018 Yu H, Lupoli TJ, Kovach A, Meng X, Zhao G, Nathan CF, Li H. ATP hydrolysis-coupled peptide translocation mechanism of ClpB. Proceedings of the National Academy of Sciences of the United States of America. PMID 30257943 DOI: 10.1073/Pnas.1810648115  0.351
2016 Lupoli TJ, Fay A, Adura C, Glickman MS, Nathan CF. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872278 DOI: 10.1073/Pnas.1617644113  0.381
2016 Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG. Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071112 DOI: 10.1073/Pnas.1524538113  0.622
2014 Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. Journal of the American Chemical Society. 136: 10874-7. PMID 25036369 DOI: 10.1021/Ja505668F  0.739
2014 Lupoli TJ, Lebar MD, Markovski M, Bernhardt T, Kahne D, Walker S. Lipoprotein activators stimulate escherichia coli penicillin-binding proteins by different mechanisms Journal of the American Chemical Society. 136: 52-55. PMID 24341982 DOI: 10.1021/Ja410813J  0.721
2014 Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. Acs Chemical Biology. 9: 459-67. PMID 24255971 DOI: 10.1021/Cb4006744  0.589
2014 Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis Journal of the American Chemical Society. 136: 10874-10877. DOI: 10.1021/ja505668f  0.691
2013 Lebar MD, Lupoli TJ, Tsukamoto H, May JM, Walker S, Kahne D. Forming cross-linked peptidoglycan from synthetic gram-negative lipid II Journal of the American Chemical Society. 135: 4632-4635. PMID 23480167 DOI: 10.1021/Ja312510M  0.746
2012 Knerr PJ, Oman TJ, Garcia De Gonzalo CV, Lupoli TJ, Walker S, Van Der Donk WA. Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation Acs Chemical Biology. 7: 1791-1795. PMID 22920239 DOI: 10.1021/Cb300372B  0.439
2011 Oman TJ, Lupoli TJ, Wang TSA, Kahne D, Walker S, Van Der Donk WA. Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry Journal of the American Chemical Society. 133: 17544-17547. PMID 22003874 DOI: 10.1021/Ja206281K  0.686
2011 Lupoli TJ, Tsukamoto H, Doud EH, Wang TS, Walker S, Kahne D. Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. Journal of the American Chemical Society. 133: 10748-51. PMID 21682301 DOI: 10.1021/Ja2040656  0.756
2011 Wang TS, Lupoli TJ, Sumida Y, Tsukamoto H, Wu Y, Rebets Y, Kahne DE, Walker S. Primer preactivation of peptidoglycan polymerases. Journal of the American Chemical Society. 133: 8528-30. PMID 21568328 DOI: 10.1021/Ja2028712  0.739
2010 Paradis-Bleau C, Markovski M, Uehara T, Lupoli TJ, Walker S, Kahne DE, Bernhardt TG. Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell. 143: 1110-20. PMID 21183074 DOI: 10.1016/J.Cell.2010.11.037  0.654
2009 Lupoli TJ, Taniguchi T, Wang TS, Perlstein DL, Walker S, Kahne DE. Studying a cell division amidase using defined peptidoglycan substrates. Journal of the American Chemical Society. 131: 18230-1. PMID 19957935 DOI: 10.1021/Ja908916Z  0.702
2007 Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. Journal of the American Chemical Society. 129: 10546-50. PMID 17685523 DOI: 10.1021/Ja072909O  0.699
2007 Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 46: 8462-71. PMID 17580964 DOI: 10.1021/Bi700433V  0.607
Low-probability matches (unlikely to be authored by this person)
2015 Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell Host & Microbe. 17: 178-90. PMID 25620549 DOI: 10.1016/J.Chom.2014.12.008  0.298
2018 Lupoli TJ, Vaubourgeix J, Burns-Huang K, Gold B. Targeting the proteostasis network for mycobacterial drug discovery. Acs Infectious Diseases. PMID 29465983 DOI: 10.1021/Acsinfecdis.7B00231  0.272
2023 Richards A, Lupoli TJ. Peptide-based molecules for the disruption of bacterial Hsp70 chaperones. Current Opinion in Chemical Biology. 76: 102373. PMID 37516006 DOI: 10.1016/j.cbpa.2023.102373  0.265
2023 Nelson B, Soper N, Lupoli TJ. Bacterial J-Domains with C-Terminal Tags Contact the Substrate Binding Domain of DnaK and Sequester Chaperone Activity. Chembiochem : a European Journal of Chemical Biology. e202300261. PMID 37556312 DOI: 10.1002/cbic.202300261  0.259
2023 Zheng M, Lupoli TJ. Counteracting antibiotic resistance enzymes and efflux pumps. Current Opinion in Microbiology. 75: 102334. PMID 37329679 DOI: 10.1016/j.mib.2023.102334  0.236
2022 Richards A, Yawson GK, Nelson B, Lupoli TJ. Complementary protocols to evaluate inhibitors against the DnaK chaperone network. Star Protocols. 3: 101381. PMID 35600924 DOI: 10.1016/j.xpro.2022.101381  0.224
2020 Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet J, Arthur M, Sacchettini JC, et al. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases Frontiers in Microbiology. 11. DOI: 10.3389/fmicb.2020.01248  0.193
2020 Harnagel A, Lopez Quezada L, Park SW, Baranowski C, Kieser K, Jiang X, Roberts J, Vaubourgeix J, Yang A, Nelson B, Fay A, Rubin E, Ehrt S, Nathan C, Lupoli TJ. Non-redundant functions of Mycobacterium tuberculosis chaperones promote survival under stress. Molecular Microbiology. PMID 32996193 DOI: 10.1111/mmi.14615  0.144
2020 Kumar K, Lupoli TJ. Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment. Acs Medicinal Chemistry Letters. 11: 1357-1360. PMID 32665808 DOI: 10.1021/Acsmedchemlett.0C00254  0.129
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