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Irene A. Chen, Ph.D. - Publications

Affiliations: 
Chemistry University of California, Santa Barbara, Santa Barbara, CA, United States 
 2005 Harvard University, Cambridge, MA, United States 
Area:
Synthetic biology, Systems Biology, Biophysics, Origin of Life, Molecular Evolution, Phage-based Applications, Human Microbiome
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Xulvi-Brunet R, Campbell GW, Rajamani S, Jiménez JI, Chen IA. Computational analysis of fitness landscapes and evolutionary networks from in vitro evolution experiments. Methods (San Diego, Calif.). PMID 27211010 DOI: 10.1016/j.ymeth.2016.05.012  0.32
2015 Saha R, Chen IA. Origin of Life: Protocells Red in Tooth and Claw. Current Biology : Cb. 25: R1175-7. PMID 26702654 DOI: 10.1016/j.cub.2015.11.007  1
2015 Pressman A, Blanco C, Chen IA. The RNA World as a Model System to Study the Origin of Life. Current Biology : Cb. 25: R953-63. PMID 26439358 DOI: 10.1016/j.cub.2015.06.016  1
2015 Chen IA. Prebiotic chemistry: Replicating towards complexity. Nature Chemistry. 7: 191-2. PMID 25698324 DOI: 10.1038/nchem.2188  1
2014 Saha R, Pohorille A, Chen IA. Molecular crowding and early evolution. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 44: 319-24. PMID 25585804 DOI: 10.1007/s11084-014-9392-3  1
2014 Athavale SS, Spicer B, Chen IA. Experimental fitness landscapes to understand the molecular evolution of RNA-based life. Current Opinion in Chemical Biology. 22: 35-9. PMID 25270912 DOI: 10.1016/j.cbpa.2014.09.008  1
2014 Freese PD, Korolev KS, Jiménez JI, Chen IA. Genetic drift suppresses bacterial conjugation in spatially structured populations. Biophysical Journal. 106: 944-54. PMID 24559997 DOI: 10.1016/j.bpj.2014.01.012  1
2013 Ivica NA, Obermayer B, Campbell GW, Rajamani S, Gerland U, Chen IA. The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability. Journal of Molecular Evolution. 77: 55-63. PMID 24078151 DOI: 10.1007/s00239-013-9584-x  1
2013 Jiménez JI, Xulvi-Brunet R, Campbell GW, Turk-MacLeod R, Chen IA. Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14984-9. PMID 23980164 DOI: 10.1073/pnas.1307604110  1
2013 Bianconi G, Zhao K, Chen IA, Nowak MA. Selection for replicases in protocells. Plos Computational Biology. 9: e1003051. PMID 23671413 DOI: 10.1371/journal.pcbi.1003051  1
2013 Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes Biochemistry. 52: 1490-1499. PMID 23360105 DOI: 10.1021/bi3016185  1
2013 Leu K, Kervio E, Obermayer B, Turk-MacLeod RM, Yuan C, Luevano JM, Chen E, Gerland U, Richert C, Chen IA. Cascade of reduced speed and accuracy after errors in enzyme-free copying of nucleic acid sequences. Journal of the American Chemical Society. 135: 354-66. PMID 23259600 DOI: 10.1021/ja3095558  1
2012 Vaidya N, Manapat ML, Chen IA, Xulvi-Brunet R, Hayden EJ, Lehman N. Spontaneous network formation among cooperative RNA replicators. Nature. 491: 72-7. PMID 23075853 DOI: 10.1038/nature11549  1
2012 Chen IA, Nowak MA. From prelife to life: how chemical kinetics become evolutionary dynamics. Accounts of Chemical Research. 45: 2088-96. PMID 22335792 DOI: 10.1021/ar2002683  1
2012 Derr J, Manapat ML, Rajamani S, Leu K, Xulvi-Brunet R, Joseph I, Nowak MA, Chen IA. Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences. Nucleic Acids Research. 40: 4711-22. PMID 22319215 DOI: 10.1093/nar/gks065  1
2011 Leu K, Obermayer B, Rajamani S, Gerland U, Chen IA. The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. Nucleic Acids Research. 39: 8135-47. PMID 21724606 DOI: 10.1093/nar/gkr525  1
2011 Lin A, Jimenez J, Derr J, Vera P, Manapat ML, Esvelt KM, Villanueva L, Liu DR, Chen IA. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. Plos One. 6: e19991. PMID 21637841 DOI: 10.1371/journal.pone.0019991  1
2010 Chen IA, Schindlinger M. Quadruplet codons: one small step for a ribosome, one giant leap for proteins: an expanded genetic code could address fundamental questions about algorithmic information, biological function, and the origins of life. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 32: 650-4. PMID 20658702 DOI: 10.1002/bies.201000051  1
2010 Chen IA, Walde P. From self-assembled vesicles to protocells. Cold Spring Harbor Perspectives in Biology. 2: a002170. PMID 20519344 DOI: 10.1101/cshperspect.a002170  1
2010 Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. Journal of the American Chemical Society. 132: 5880-5. PMID 20359213 DOI: 10.1021/ja100780p  1
2010 Manapat ML, Chen IA, Nowak MA. The basic reproductive ratio of life. Journal of Theoretical Biology. 263: 317-27. PMID 20034501 DOI: 10.1016/j.jtbi.2009.12.020  1
2009 Chen IA. Cell division: breaking up is easy to do. Current Biology : Cb. 19: R327-8. PMID 19409280 DOI: 10.1016/j.cub.2009.03.002  1
2006 Chen IA. GE Prize-winning essay. The emergence of cells during the origin of life. Science (New York, N.Y.). 314: 1558-9. PMID 17158315 DOI: 10.1126/science.1137541  1
2005 Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles Langmuir. 21: 12124-12129. PMID 16342983 DOI: 10.1021/la052590q  1
2005 Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles Journal of the American Chemical Society. 127: 13213-13219. PMID 16173749 DOI: 10.1021/ja051784p  1
2004 Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science (New York, N.Y.). 305: 1474-6. PMID 15353806 DOI: 10.1126/science.1100757  1
2004 Chen IA, Szostak JW. A kinetic study of the growth of fatty acid vesicles Biophysical Journal. 87: 988-998. PMID 15298905 DOI: 10.1529/biophysj.104.039875  1
2004 Chen IA, Szostak JW. Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles Proceedings of the National Academy of Sciences of the United States of America. 101: 7965-7970. PMID 15148394 DOI: 10.1073/pnas.0308045101  1
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