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Rajat Rohatgi - Publications

Affiliations: 
Oncology Stanford University School of Medicine, Palo Alto, CA, United States 
Area:
Biochemical Mechanisms of Hedgehog (Hh) Signaling
Website:
http://rohatgi.stanford.edu/
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78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Khandwala CB, Sarkar P, Schmidt HB, Ma M, Kinnebrew M, Pusapati GV, Patel BB, Tillo D, Lebensohn AM, Rohatgi R. Direct ionic stress sensing and mitigation by the transcription factor NFAT5. Biorxiv : the Preprint Server For Biology. PMID 37886503 DOI: 10.1101/2023.09.23.559074  0.723
2023 Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, ... ... Rohatgi R, et al. The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature Communications. 14: 6173. PMID 37798301 DOI: 10.1038/s41467-023-41836-z  0.782
2023 Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, et al. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nature Communications. 14: 6174. PMID 37798281 DOI: 10.1038/s41467-023-41843-0  0.784
2023 Siebold C, Rohatgi R. The Inseparable Relationship Between Cholesterol and Hedgehog Signaling. Annual Review of Biochemistry. PMID 37001135 DOI: 10.1146/annurev-biochem-052521-040313  0.359
2022 Schmidt HB, Jaafar ZA, Wulff BE, Rodencal JJ, Hong K, Aziz-Zanjani MO, Jackson PK, Leonetti MD, Dixon SJ, Rohatgi R, Brandman O. Oxaliplatin disrupts nucleolar function through biophysical disintegration. Cell Reports. 41: 111629. PMID 36351392 DOI: 10.1016/j.celrep.2022.111629  0.444
2022 Lebensohn AM, Bazan JF, Rohatgi R. Receptor control by membrane-tethered ubiquitin ligases in development and tissue homeostasis. Current Topics in Developmental Biology. 150: 25-89. PMID 35817504 DOI: 10.1016/bs.ctdb.2022.03.003  0.76
2021 Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature Communications. 12: 7171. PMID 34887403 DOI: 10.1038/s41467-021-27475-2  0.308
2021 Zhao Z, Lee RTH, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Embo Reports. 22: e52895. PMID 33949092 DOI: 10.15252/embr.202152895  0.392
2020 Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, ... ... Rohatgi R, et al. Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. Embo Molecular Medicine. 12: e11739. PMID 33200460 DOI: 10.15252/emmm.201911739  0.325
2020 Radhakrishnan A, Rohatgi R, Siebold C. Cholesterol access in cellular membranes controls Hedgehog signaling. Nature Chemical Biology. 16: 1303-1313. PMID 33199907 DOI: 10.1038/s41589-020-00678-2  0.343
2020 Kong JH, Young CB, Pusapati GV, Patel CB, Ho S, Krishnan A, Lin JI, Devine W, Moreau de Bellaing A, Athni TS, Aravind L, Gunn TM, Lo CW, Rohatgi R. A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Developmental Cell. PMID 32966817 DOI: 10.1016/j.devcel.2020.08.012  0.363
2020 Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. Elife. 9. PMID 32432544 DOI: 10.7554/Elife.54469  0.793
2020 Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R. Lipid droplets can promote drug accumulation and activation. Nature Chemical Biology. PMID 31932720 DOI: 10.1038/S41589-019-0447-7  0.334
2020 Dubey R, Kerkhof Pv, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. Author response: R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling Elife. DOI: 10.7554/Elife.54469.Sa2  0.757
2019 Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling. Elife. 8. PMID 31657721 DOI: 10.7554/Elife.50051  0.394
2019 Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, ... Rohatgi R, et al. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature Chemical Biology. PMID 31548691 DOI: 10.1038/S41589-019-0370-Y  0.346
2019 Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C. Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling. Current Opinion in Structural Biology. 57: 204-214. PMID 31247512 DOI: 10.1016/J.Sbi.2019.05.015  0.498
2019 Kong JH, Siebold C, Rohatgi R. Biochemical mechanisms of vertebrate hedgehog signaling. Development (Cambridge, England). 146. PMID 31092502 DOI: 10.1242/Dev.166892  0.511
2019 Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R. Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. Plos One. 14: e0198463. PMID 30695034 DOI: 10.1371/Journal.Pone.0198463  0.733
2019 Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Author response: Cholesterol accessibility at the ciliary membrane controls hedgehog signaling Elife. DOI: 10.7554/Elife.50051.025  0.363
2019 Lebensohn AM, Rohatgi R. Abstract 3445: Mechanism, physiological and therapeutic implications of LGR-independent potentiation of WNT signaling by R-spondins Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3445  0.764
2018 Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP. Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened. Structure (London, England : 1993). PMID 30595453 DOI: 10.1016/J.Str.2018.11.003  0.317
2018 Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC. Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nature Communications. 9: 1732. PMID 29712905 DOI: 10.1038/S41467-018-03952-Z  0.453
2018 Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R. G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog. Science Signaling. 11. PMID 29438014 DOI: 10.1126/Scisignal.Aao5749  0.482
2018 Lebensohn AM, Rohatgi R. R-spondins can potentiate WNT signaling without LGRs. Elife. 7. PMID 29405118 DOI: 10.7554/Elife.33126  0.8
2017 Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Developmental Cell. PMID 29290584 DOI: 10.1016/J.Devcel.2017.12.003  0.515
2017 Byrne EF, Luchetti G, Rohatgi R, Siebold C. Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates. Current Opinion in Cell Biology. 51: 81-88. PMID 29268141 DOI: 10.1016/J.Ceb.2017.10.004  0.51
2017 Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 168: 264-279.e15. PMID 28086093 DOI: 10.1016/J.Cell.2016.12.032  0.385
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife. 5. PMID 27996937 DOI: 10.7554/Elife.21459  0.803
2016 Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling. Elife. 5. PMID 27705744 DOI: 10.7554/Elife.20304  0.429
2016 Dubey R, Lebensohn A, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R. Chromatin-remodeling complex SWI/SNF controls multidrug resistance by transcriptionally regulating the drug efflux pump ABCB1. Cancer Research. PMID 27503929 DOI: 10.1158/0008-5472.Can-16-0716  0.722
2016 Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold C. Structural basis of Smoothened regulation by its extracellular domains. Nature. PMID 27437577 DOI: 10.1038/Nature18934  0.388
2016 Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Embo Reports. PMID 27113758 DOI: 10.15252/Embr.201541532  0.426
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Author response: Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling Elife. DOI: 10.7554/Elife.21459.025  0.768
2016 Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Author response: Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling Elife. DOI: 10.7554/Elife.20304.015  0.389
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly O, Marceau CD, Bahrami Z, Hansen AG, Ahmed Y, Lee E, Carette J, Rohatgi R. Abstract PR05: Systematic forward genetic screens in haploid human cells reveal new players and regulatory mechanisms in Wnt signaling Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Pr05  0.801
2015 Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ, Ogden SK. Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. Plos Genetics. 11: e1005473. PMID 26291458 DOI: 10.1371/Journal.Pgen.1005473  0.512
2015 Niewiadomski P, Rohatgi R. Rapid Screening of Gli2/3 Mutants Using the Flp-In System. Methods in Molecular Biology (Clifton, N.J.). 1322: 125-30. PMID 26179044 DOI: 10.1007/978-1-4939-2772-2_11  0.401
2015 Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R. Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry. Methods in Molecular Biology (Clifton, N.J.). 1322: 105-23. PMID 26179043 DOI: 10.1007/978-1-4939-2772-2_10  0.319
2015 Niewiadomski P, Rohatgi R. Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR. Methods in Molecular Biology (Clifton, N.J.). 1322: 81-92. PMID 26179041 DOI: 10.1007/978-1-4939-2772-2_8  0.345
2015 Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Developmental Cell. 33: 373-87. PMID 25936505 DOI: 10.1016/J.Devcel.2015.03.005  0.459
2014 Pusapati GV, Rohatgi R. Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia. The Embo Journal. 33: 1852-4. PMID 25037564 DOI: 10.15252/Embj.201489294  0.504
2014 Guerrero I, Rohatgi R. Frontiers in hedgehog signal transduction. Seminars in Cell & Developmental Biology. 33: 50-1. PMID 24946961 DOI: 10.1016/J.Semcdb.2014.06.009  0.474
2014 Mukhopadhyay S, Rohatgi R. G-protein-coupled receptors, Hedgehog signaling and primary cilia. Seminars in Cell & Developmental Biology. 33: 63-72. PMID 24845016 DOI: 10.1016/J.Semcdb.2014.05.002  0.504
2014 Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. The Journal of Biological Chemistry. 289: 11095-110. PMID 24596093 DOI: 10.1074/Jbc.M113.540351  0.373
2014 Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, et al. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 1872-85. PMID 24591126 DOI: 10.1002/Jbmr.2213  0.319
2014 Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Developmental Cell. 28: 483-96. PMID 24582806 DOI: 10.1016/J.Devcel.2014.01.021  0.513
2014 Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Reports. 6: 168-81. PMID 24373970 DOI: 10.1016/J.Celrep.2013.12.003  0.421
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2: e01340. PMID 24171105 DOI: 10.7554/Elife.01340  0.466
2013 Lin YC, Niewiadomski P, Lin B, Nakamura H, Phua SC, Jiao J, Levchenko A, Inoue T, Rohatgi R, Inoue T. Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier. Nature Chemical Biology. 9: 437-43. PMID 23666116 DOI: 10.1038/Nchembio.1252  0.324
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Author response: Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife. DOI: 10.7554/Elife.01340.020  0.379
2013 Lebensohn A, Hughes C, Marceau C, Rohatgi R, Carette J. Abstract PR03: Genome-wide screens for Wnt signaling in human haploid cells Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr03  0.785
2013 Inoue T, Lin Y, Lin B, Phua SC, Jiao J, Levchenko A, Niewiadomski P, Rohatgi R, Nakamura H, Inoue T. Illuminating Passive Permeability Barrier of Primary Cilia using Novel Diffusion Trap Technique Biophysical Journal. 104: 31a-32a. DOI: 10.1016/J.Bpj.2012.11.212  0.349
2012 Dorn KV, Hughes CE, Rohatgi R. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. Developmental Cell. 23: 823-35. PMID 22981989 DOI: 10.1016/J.Devcel.2012.07.004  0.539
2012 Briscoe J, Rohatgi R. Singapore signalling: the 2012 hedgehog pathway cocktail. Embo Reports. 13: 580-3. PMID 22688966 DOI: 10.1038/Embor.2012.79  0.452
2012 Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nature Chemical Biology. 8: 211-20. PMID 22231273 DOI: 10.1038/Nchembio.765  0.494
2011 Nachtergaele S, Mydock L, Krishnan K, Covey D, Rohatgi R. Abstract LB-238: Regulation of signaling pathways by endogenous small molecules Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-238  0.42
2010 Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Developmental Cell. 19: 54-65. PMID 20643350 DOI: 10.1016/J.Devcel.2010.06.007  0.577
2010 Rohatgi R, Snell WJ. The ciliary membrane. Current Opinion in Cell Biology. 22: 541-6. PMID 20399632 DOI: 10.1016/J.Ceb.2010.03.010  0.305
2010 Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes & Development. 24: 670-82. PMID 20360384 DOI: 10.1101/Gad.1902910  0.629
2009 Milenkovic L, Scott MP, Rohatgi R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. The Journal of Cell Biology. 187: 365-74. PMID 19948480 DOI: 10.1083/Jcb.200907126  0.554
2009 Simons M, Gault WJ, Gotthardt D, Rohatgi R, Klein TJ, Shao Y, Lee HJ, Wu AL, Fang Y, Satlin LM, Dow JT, Chen J, Zheng J, Boutros M, Mlodzik M. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nature Cell Biology. 11: 286-94. PMID 19234454 DOI: 10.1038/Ncb1836  0.368
2009 Rohatgi R, Milenkovic L, Corcoran RB, Scott MP. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proceedings of the National Academy of Sciences of the United States of America. 106: 3196-201. PMID 19218434 DOI: 10.1073/Pnas.0813373106  0.731
2009 Scott M, Rohatgi R, Milenkovic L, Lee E, Corcoran R, Barakat M, Humke E. S02-04 Communicating with Hedgehogs: Signaling in development and disease Mechanisms of Development. 126: S26-S27. DOI: 10.1016/J.Mod.2009.06.1065  0.728
2008 Rohatgi R, Scott MP. Cell biology. Arrestin' movement in cilia. Science (New York, N.Y.). 320: 1726-7. PMID 18583599 DOI: 10.1126/Science.1160448  0.562
2007 Rohatgi R, Scott MP. Patching the gaps in Hedgehog signalling. Nature Cell Biology. 9: 1005-9. PMID 17762891 DOI: 10.1038/Ncb435  0.633
2007 Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science (New York, N.Y.). 317: 372-6. PMID 17641202 DOI: 10.1126/Science.1139740  0.643
2006 Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW. In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods in Enzymology. 406: 174-90. PMID 16472658 DOI: 10.1016/S0076-6879(06)06014-9  0.773
2004 Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118: 203-16. PMID 15260990 DOI: 10.1016/J.Cell.2004.06.027  0.78
2002 Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418: 790-3. PMID 12181570 DOI: 10.1038/Nature00859  0.526
2001 Ho HY, Rohatgi R, Ma L, Kirschner MW. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proceedings of the National Academy of Sciences of the United States of America. 98: 11306-11. PMID 11553796 DOI: 10.1073/Pnas.211420498  0.639
2001 Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. The Journal of Biological Chemistry. 276: 26448-52. PMID 11340081 DOI: 10.1074/Jbc.M103856200  0.539
2001 Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nature Cell Biology. 3: 484-91. PMID 11331876 DOI: 10.1038/35074551  0.339
2000 Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. The Journal of Cell Biology. 150: 1299-310. PMID 10995436 DOI: 10.1083/Jcb.150.6.1299  0.55
1999 Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97: 221-31. PMID 10219243 DOI: 10.1016/S0092-8674(00)80732-1  0.682
1998 Ma L, Rohatgi R, Kirschner MW. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proceedings of the National Academy of Sciences of the United States of America. 95: 15362-7. PMID 9860974 DOI: 10.1073/Pnas.95.26.15362  0.68
1996 Rohatgi R, Bartel DP, Szostak JW. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. Journal of the American Chemical Society. 118: 3340-4. PMID 11539268 DOI: 10.1021/Ja9537134  0.455
1996 Rohatgi R, Bartel DP, Szostak JW. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. Journal of the American Chemical Society. 118: 3332-9. PMID 11539267 DOI: 10.1021/Ja953712B  0.456
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