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Joan Blanchette Broderick, Ph.D. - Publications

Affiliations: 
1993-1998 Amherst College, Amherst, MA, United States 
 1998-2005 Michigan State University, East Lansing, MI 
 2005- Chemistry Montana State University, Bozeman, MT 
Area:
Bioinorganic Chemistry; Mechanisms of Metalloenzyme-mediated Reactions; Mechanisms of Biological Radical Reactions; Bioremediation
Website:
https://www.chemistry.montana.edu/people/person.php?id=24
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108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yang H, Ho MB, Lundahl MN, Mosquera MA, Broderick WE, Broderick JB, Hoffman BM. ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] Cluster. Journal of the American Chemical Society. PMID 38308759 DOI: 10.1021/jacs.3c09428  0.537
2023 Lundahl MN, Yang H, Broderick WE, Hoffman BM, Broderick JB. Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction. Proceedings of the National Academy of Sciences of the United States of America. 120: e2314696120. PMID 37956301 DOI: 10.1073/pnas.2314696120  0.424
2023 Balci B, O'Neill RD, Shepard EM, Pagnier A, Marlott A, Mock MT, Broderick WE, Broderick JB. Semisynthetic maturation of [FeFe]-hydrogenase using [Fe(μ-SH)(CN)(CO)]: key roles for HydF and GTP. Chemical Communications (Cambridge, England). PMID 37376915 DOI: 10.1039/d3cc02169f  0.422
2023 Jodts RJ, Wittkop M, Ho MB, Broderick WE, Broderick JB, Hoffman BM, Mosquera MA. Computational Description of Alkylated Iron-Sulfur Organometallic Clusters. Journal of the American Chemical Society. PMID 37307050 DOI: 10.1021/jacs.3c03062  0.513
2023 Moody JD, Hill S, Lundahl MN, Saxton AJ, Galambas A, Broderick WE, Lawrence CM, Broderick JB. Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage. The Journal of Biological Chemistry. 104791. PMID 37156396 DOI: 10.1016/j.jbc.2023.104791  0.385
2023 Hoffman BM, Broderick WE, Broderick JB. Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily. Annual Review of Biochemistry. PMID 37018846 DOI: 10.1146/annurev-biochem-052621-090638  0.446
2022 Broderick JB, Broderick WE, Hoffman BM. Radical SAM enzymes: Nature's choice for radical reactions. Febs Letters. PMID 36251330 DOI: 10.1002/1873-3468.14519  0.473
2022 Pagnier A, Balci B, Shepard EM, Broderick WE, Broderick JB. [FeFe]-Hydrogenase In Vitro Maturation. Angewandte Chemie (International Ed. in English). PMID 36137942 DOI: 10.1002/anie.202212074  0.366
2022 Steward KF, Payne D, Kincannon W, Johnson C, Lensing M, Fausset H, Németh B, Shepard EM, Broderick WE, Broderick JB, Dubois J, Bothner B. Proteomic Analysis of Methanococcus voltae Grown in the Presence of Mineral and Nonmineral Sources of Iron and Sulfur. Microbiology Spectrum. e0189322. PMID 35876569 DOI: 10.1128/spectrum.01893-22  0.831
2022 Broderick JB. Unraveling the secrets of radical SAM mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35554999 DOI: 10.1096/fasebj.2022.36.S1.0I187  0.478
2022 Pagnier A, Balci B, Shepard EM, Yang H, Warui DM, Impano S, Booker SJ, Hoffman BM, Broderick WE, Broderick JB. [FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 35319808 DOI: 10.1002/anie.202203413  0.682
2022 Lundahl MN, Sarksian R, Yang H, Jodts RJ, Pagnier A, Smith DF, Mosquera MA, van der Donk WA, Hoffman BM, Broderick WE, Broderick JB. l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. Journal of the American Chemical Society. PMID 35258967 DOI: 10.1021/jacs.1c13706  0.581
2021 Walls WG, Moody JD, McDaniel EC, Villanueva M, Shepard EM, Broderick WE, Broderick JB. The B-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine. Journal of Inorganic Biochemistry. 227: 111662. PMID 34847521 DOI: 10.1016/j.jinorgbio.2021.111662  0.372
2021 Payne D, Shepard EM, Spietz RL, Steward K, Brumfield S, Young M, Bothner B, Broderick WE, Broderick JB, Boyd ES. Examining pathways of iron and sulfur acquisition, trafficking, deployment, and storage in mineral-grown methanogen cells. Journal of Bacteriology. JB0014621. PMID 34251867 DOI: 10.1128/JB.00146-21  0.362
2021 Shepard EM, Impano S, Duffus BR, Pagnier A, Duschene KS, Betz JN, Byer AS, Galambas A, McDaniel EC, Watts H, McGlynn SE, Peters JW, Broderick WE, Broderick JB. HydG, the "dangler" iron, and catalytic production of free CO and CN: implications for [FeFe]-hydrogenase maturation. Dalton Transactions (Cambridge, England : 2003). PMID 34240096 DOI: 10.1039/d1dt01359a  0.487
2021 Impano S, Yang H, Shepard EM, Swimley R, Pagnier A, Broderick WE, Hoffman BM, Broderick JB. -Adenosyl-l-ethionine is a Catalytically Competent Analog of -Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG. Angewandte Chemie (International Ed. in English). 60: 4666-4672. PMID 33935588 DOI: 10.1002/anie.202014337  0.51
2020 Impano S, Yang H, Jodts RJ, Pagnier A, Swimley R, McDaniel EC, Shepard EM, Broderick WE, Broderick JB, Hoffman BM. Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of -Adenosylmethionine in Radical SAM Enzymes. Journal of the American Chemical Society. PMID 33372786 DOI: 10.1021/jacs.0c10925  0.397
2020 Pagnier A, Yang H, Jodts R, James C, Shepard EM, Impano S, Broderick W, Hoffman BM, Broderick JB. The Radical SAM enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed During Substrate-Free Turnover. Journal of the American Chemical Society. PMID 32966073 DOI: 10.1021/jacs.0c08585  0.481
2020 Németh B, Senger M, Redman HJ, Ceccaldi P, Broderick J, Magnuson A, Stripp ST, Haumann M, Berggren G. [FeFe]-hydrogenase maturation: H-cluster assembly intermediates tracked by electron paramagnetic resonance, infrared, and X-ray absorption spectroscopy. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 25: 777-788. PMID 32661785 DOI: 10.1007/S00775-020-01799-8  0.838
2019 Yang H, Impano S, Shepard EM, James CD, Broderick WE, Broderick JB, Hoffman BM. Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical. Journal of the American Chemical Society. PMID 31509404 DOI: 10.1021/Jacs.9B08541  0.546
2019 Broderick WE, Broderick JB. Radical SAM enzymes: surprises along the path to understanding mechanism. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31494759 DOI: 10.1007/S00775-019-01706-W  0.573
2019 Byer AS, Shepard EM, Ratzloff MW, Betz JN, King PW, Broderick WE, Broderick JB. H-cluster assembly intermediates built on HydF by the radical SAM enzymes HydE and HydG. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31493152 DOI: 10.1007/S00775-019-01709-7  0.602
2019 Galambas A, Miller J, Jones M, McDaniel E, Lukes M, Watts H, Copié V, Broderick JB, Szilagyi RK, Shepard EM. Radical S-adenosylmethionine maquette chemistry: CxCxC peptide coordinated redox active [4Fe-4S] clusters. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31486952 DOI: 10.1007/S00775-019-01708-8  0.603
2019 Yang H, McDaniel E, Impano S, Byer AS, Jodts RJ, Yokoyama K, Broderick WE, Broderick JB, Hoffman BM. The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by EPR and ENDOR Spectroscopies. Journal of the American Chemical Society. PMID 31274303 DOI: 10.1021/Jacs.9B05926  0.466
2019 Adelson CN, Johnston EM, Hilmer KM, Watts H, Dey SG, Brown DE, Broderick JB, Shepard EM, Dooley DM, Solomon EI. Characterization of the preprocessed copper site equilibrium in amine oxidase and assignment of the reactive copper site in topaquinone biogenesis. Journal of the American Chemical Society. PMID 31060358 DOI: 10.1021/Jacs.9B01922  0.385
2019 Hanscam R, Shepard EM, Broderick JB, Copié V, Szilagyi RK. Secondary structure analysis of peptides with relevance to iron-sulfur cluster nesting. Journal of Computational Chemistry. 40: 515-526. PMID 30548652 DOI: 10.1002/Jcc.25741  0.473
2018 Broderick WE, Hoffman BM, Broderick JB. Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily. Accounts of Chemical Research. PMID 30346729 DOI: 10.1021/Acs.Accounts.8B00356  0.648
2018 Byer AS, McDaniel EC, Impano S, Broderick WE, Broderick JB. Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies. Methods in Enzymology. 606: 269-318. PMID 30097096 DOI: 10.1016/Bs.Mie.2018.04.013  0.595
2018 Scott AG, Szilagyi RK, Mulder DW, Ratzloff MW, Byer AS, King PW, Broderick WE, Shepard EM, Broderick JB. Compositional and structural insights into the nature of the H-cluster precursor on HydF. Dalton Transactions (Cambridge, England : 2003). PMID 29964288 DOI: 10.1039/C8Dt01654B  0.566
2018 Byer AS, Yang H, McDaniel EC, Kathiresan V, Impano S, Pagnier A, Watts H, Denler C, Vagstad A, Piel J, Duschene KS, Shepard EM, Shields TP, Scott LG, Lilla EA, ... ... Broderick JB, et al. A paradigm shift for radical SAM reactions: The organometallic intermediate Ω is central to catalysis. Journal of the American Chemical Society. PMID 29954180 DOI: 10.1021/Jacs.8B04061  0.504
2017 Shepard EM, Byer AS, Broderick JB. Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF. Biochemistry. PMID 28853860 DOI: 10.1021/Acs.Biochem.7B00735  0.473
2017 Shisler KA, Hutcheson RU, Horitani M, Duschene KS, Crain AV, Byer AS, Shepard EM, Rasmussen A, Yang J, Broderick WE, Vey JL, Drennan CL, Hoffman BM, Broderick JB. Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme. Journal of the American Chemical Society. PMID 28768413 DOI: 10.1021/Jacs.7B04883  0.84
2017 Shepard EM, Byer AS, Aggarwal P, Betz JN, Scott AG, Shisler K, Usselman RJ, Eaton GR, Eaton SS, Broderick JB. Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation. Biochemistry. PMID 28525271 DOI: 10.1021/Acs.Biochem.7B00169  0.614
2016 Broderick JB, Moody JD. Cutting Choline with Radical Scissors. Cell Chemical Biology. 23: 1173-1174. PMID 27768865 DOI: 10.1016/J.Chembiol.2016.10.002  0.334
2016 Shepard EM, Byer AS, Betz JN, Peters JW, Broderick JB. A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF. Biochemistry. PMID 27232385 DOI: 10.1021/Acs.Biochem.6B00528  0.604
2016 Horitani M, Shisler K, Broderick WE, Hutcheson RU, Duschene KS, Marts AR, Hoffman BM, Broderick JB. Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond. Science (New York, N.Y.). 352: 822-5. PMID 27174986 DOI: 10.1126/Science.Aaf5327  0.621
2015 Horitani M, Byer AS, Shisler KA, Chandra T, Broderick JB, Hoffman BM. Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5'-dAdo• "Free Radical" Is Never Free. Journal of the American Chemical Society. 137: 7111-21. PMID 25923449 DOI: 10.1021/Jacs.5B00498  0.515
2015 Lill R, Broderick JB, Dean DR. Special issue on iron-sulfur proteins: Structure, function, biogenesis and diseases. Biochimica Et Biophysica Acta. 1853: 1251-2. PMID 25746719 DOI: 10.1016/J.Bbamcr.2015.03.001  0.348
2015 Betz JN, Boswell NW, Fugate CJ, Holliday GL, Akiva E, Scott AG, Babbitt PC, Peters JW, Shepard EM, Broderick JB. [FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis. Biochemistry. 54: 1807-18. PMID 25654171 DOI: 10.1021/Bi501205E  0.579
2015 Swanson KD, Ratzloff MW, Mulder DW, Artz JH, Ghose S, Hoffman A, White S, Zadvornyy OA, Broderick JB, Bothner B, King PW, Peters JW. [FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster. Journal of the American Chemical Society. 137: 1809-16. PMID 25579778 DOI: 10.1021/Ja510169S  0.536
2015 Byer AS, Shepard EM, Peters JW, Broderick JB. Radical S-adenosyl-L-methionine chemistry in the synthesis of hydrogenase and nitrogenase metal cofactors. The Journal of Biological Chemistry. 290: 3987-94. PMID 25477518 DOI: 10.1074/Jbc.R114.578161  0.592
2015 Peters JW, Schut GJ, Boyd ES, Mulder DW, Shepard EM, Broderick JB, King PW, Adams MW. [FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation. Biochimica Et Biophysica Acta. 1853: 1350-1369. PMID 25461840 DOI: 10.1016/J.Bbamcr.2014.11.021  0.459
2014 Duffus BR, Ghose S, Peters JW, Broderick JB. Reversible H atom abstraction catalyzed by the radical S-adenosylmethionine enzyme HydG. Journal of the American Chemical Society. 136: 13086-9. PMID 25099480 DOI: 10.1021/Ja504618Y  0.48
2014 Broderick JB, Byer AS, Duschene KS, Duffus BR, Betz JN, Shepard EM, Peters JW. H-cluster assembly during maturation of the [FeFe]-hydrogenase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 19: 747-57. PMID 24972661 DOI: 10.1007/S00775-014-1168-8  0.535
2014 Ghose S, Hilmer JK, Bothner B, Broderick JB. Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange. Febs Letters. 588: 3023-9. PMID 24950428 DOI: 10.1016/J.Febslet.2014.06.011  0.413
2014 Shepard EM, Mus F, Betz JN, Byer AS, Duffus BR, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation. Biochemistry. 53: 4090-104. PMID 24878200 DOI: 10.1021/Bi500210X  0.611
2014 Silver SC, Gardenghi DJ, Naik SG, Shepard EM, Huynh BH, Szilagyi RK, Broderick JB. Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 19: 465-83. PMID 24532333 DOI: 10.1007/S00775-014-1104-Y  0.821
2014 Shisler KA, Broderick JB. Glycyl radical activating enzymes: structure, mechanism, and substrate interactions. Archives of Biochemistry and Biophysics. 546: 64-71. PMID 24486374 DOI: 10.1016/J.Abb.2014.01.020  0.535
2014 Broderick JB, Duffus BR, Duschene KS, Shepard EM. Radical S-adenosylmethionine enzymes. Chemical Reviews. 114: 4229-317. PMID 24476342 DOI: 10.1021/Cr4004709  0.553
2014 Crain AV, Broderick JB. Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme. The Journal of Biological Chemistry. 289: 5723-9. PMID 24338017 DOI: 10.1074/Jbc.M113.496877  0.832
2014 Ortillo DO, Broderick JB. Spectroscopic investigation of Pyruvate formate lyase-activating enzyme: A look into EPR, ENDOR and Mössabuer spectroscopy Research Journal of Applied Sciences, Engineering and Technology. 8: 1075-1097. DOI: 10.19026/Rjaset.8.1072  0.862
2014 Boyd ES, Schut GJ, Shepard EM, Broderick JB, Adams MWW, Peters JW. Origin and evolution of Fe-S proteins and enzymes Iron-Sulfur Clusters in Chemistry and Biology. 619-636. DOI: 10.1515/9783110308426.619  0.439
2014 Shepard EM, Mus F, Betz JN, Byer AS, Duffus BR, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation (Biochemistry (2014) 53:25 (4090-4104) DOI:10.1021/bi500210x) Biochemistry. 53: 5588. DOI: 10.1021/Bi500981N  0.314
2013 Driesener RC, Duffus BR, Shepard EM, Bruzas IR, Duschene KS, Coleman NJ, Marrison AP, Salvadori E, Kay CW, Peters JW, Broderick JB, Roach PL. Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG. Biochemistry. 52: 8696-707. PMID 24206022 DOI: 10.1021/Bi401143S  0.559
2013 Crain AV, Broderick JB. Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme. Biochimica Et Biophysica Acta. 1834: 2512-9. PMID 24016774 DOI: 10.1016/J.Bbapap.2013.08.014  0.784
2013 Mulder DW, Ratzloff MW, Shepard EM, Byer AS, Noone SM, Peters JW, Broderick JB, King PW. EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii. Journal of the American Chemical Society. 135: 6921-9. PMID 23578101 DOI: 10.1021/Ja4000257  0.51
2012 Shisler KA, Broderick JB. Emerging themes in radical SAM chemistry. Current Opinion in Structural Biology. 22: 701-10. PMID 23141873 DOI: 10.1016/J.Sbi.2012.10.005  0.612
2012 Joshi N, Shepard EM, Byer AS, Swanson KD, Broderick JB, Peters JW. Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF. Febs Letters. 586: 3939-43. PMID 23041346 DOI: 10.1016/J.Febslet.2012.09.028  0.559
2012 Hutcheson RU, Broderick JB. Radical SAM enzymes in methylation and methylthiolation. Metallomics : Integrated Biometal Science. 4: 1149-54. PMID 22992596 DOI: 10.1039/C2Mt20136D  0.609
2012 Peters JW, Broderick JB. Emerging paradigms for complex iron-sulfur cofactor assembly and insertion. Annual Review of Biochemistry. 81: 429-50. PMID 22482905 DOI: 10.1146/Annurev-Biochem-052610-094911  0.586
2012 Kim SH, Harzman C, Davis JK, Hutcheson R, Broderick JB, Marsh TL, Tiedje JM. Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction. Bmc Microbiology. 12: 21. PMID 22316246 DOI: 10.1186/1471-2180-12-21  0.723
2012 Duffus BR, Hamilton TL, Shepard EM, Boyd ES, Peters JW, Broderick JB. Radical AdoMet enzymes in complex metal cluster biosynthesis. Biochimica Et Biophysica Acta. 1824: 1254-63. PMID 22269887 DOI: 10.1016/J.Bbapap.2012.01.002  0.615
2011 Dey A, Peng Y, Broderick WE, Hedman B, Hodgson KO, Broderick JB, Solomon EI. S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. Journal of the American Chemical Society. 133: 18656-62. PMID 21992686 DOI: 10.1021/Ja203780T  0.683
2011 Mulder DW, Shepard EM, Meuser JE, Joshi N, King PW, Posewitz MC, Broderick JB, Peters JW. Insights into [FeFe]-hydrogenase structure, mechanism, and maturation. Structure (London, England : 1993). 19: 1038-52. PMID 21827941 DOI: 10.1016/J.Str.2011.06.008  0.475
2011 Shepard EM, Boyd ES, Broderick JB, Peters JW. Biosynthesis of complex iron-sulfur enzymes. Current Opinion in Chemical Biology. 15: 319-27. PMID 21393052 DOI: 10.1016/J.Cbpa.2011.02.012  0.638
2011 Swanson KD, Duffus BR, Beard TE, Peters JW, Broderick JB. Cyanide and carbon monoxide ligand formation in hydrogenase biosynthesis European Journal of Inorganic Chemistry. 935-947. DOI: 10.1002/Ejic.201001056  0.505
2010 Peng Y, Veneziano SE, Gillispie GD, Broderick JB. Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme. The Journal of Biological Chemistry. 285: 27224-31. PMID 20571026 DOI: 10.1074/Jbc.M109.096875  0.569
2010 Shepard EM, Duffus BR, George SJ, McGlynn SE, Challand MR, Swanson KD, Roach PL, Cramer SP, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. Journal of the American Chemical Society. 132: 9247-9. PMID 20565074 DOI: 10.1021/Ja1012273  0.498
2010 Broderick JB. Biochemistry: A radically different enzyme. Nature. 465: 877-8. PMID 20559373 DOI: 10.1038/465877A  0.522
2010 Shepard EM, McGlynn SE, Bueling AL, Grady-Smith CS, George SJ, Winslow MA, Cramer SP, Peters JW, Broderick JB. Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proceedings of the National Academy of Sciences of the United States of America. 107: 10448-53. PMID 20498089 DOI: 10.1073/Pnas.1001937107  0.587
2010 Mulder DW, Boyd ES, Sarma R, Lange RK, Endrizzi JA, Broderick JB, Peters JW. Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG). Nature. 465: 248-51. PMID 20418861 DOI: 10.1038/Nature08993  0.589
2010 Silver SC, Chandra T, Zilinskas E, Ghose S, Broderick WE, Broderick JB. Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 943-55. PMID 20405152 DOI: 10.1007/S00775-010-0656-8  0.816
2010 Duschene KS, Broderick JB. The antiviral protein viperin is a radical SAM enzyme. Febs Letters. 584: 1263-7. PMID 20176015 DOI: 10.1016/J.Febslet.2010.02.041  0.6
2010 Driesener RC, Challand MR, McGlynn SE, Shepard EM, Boyd ES, Broderick JB, Peters JW, Roach PL. [FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. Angewandte Chemie (International Ed. in English). 49: 1687-90. PMID 20108298 DOI: 10.1002/Anie.200907047  0.526
2010 McGlynn SE, Boyd ES, Shepard EM, Lange RK, Gerlach R, Broderick JB, Peters JW. Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. Journal of Bacteriology. 192: 595-8. PMID 19897660 DOI: 10.1128/Jb.01125-09  0.421
2010 Shepard EM, Broderick JB. S-adenosylmethionine and iron-sulfur clusters in biological radical reactions: The radical SAM superfamily Comprehensive Natural Products Ii: Chemistry and Biology. 8: 625-661.  0.447
2009 Yang J, Naik SG, Ortillo DO, García-Serres R, Li M, Broderick WE, Huynh BH, Broderick JB. The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state. Biochemistry. 48: 9234-41. PMID 19711960 DOI: 10.1021/Bi9010286  0.854
2009 McGlynn SE, Mulder DW, Shepard EM, Broderick JB, Peters JW. Hydrogenase cluster biosynthesis: organometallic chemistry nature's way. Dalton Transactions (Cambridge, England : 2003). 4274-85. PMID 19662302 DOI: 10.1039/B821432H  0.46
2009 Mulder DW, Ortillo DO, Gardenghi DJ, Naumov AV, Ruebush SS, Szilagyi RK, Huynh B, Broderick JB, Peters JW. Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster. Biochemistry. 48: 6240-8. PMID 19435321 DOI: 10.1021/Bi9000563  0.853
2009 Bollinger JM, Broderick JB. Frontiers in enzymatic C-H-bond activation. Current Opinion in Chemical Biology. 13: 51-7. PMID 19362514 DOI: 10.1016/J.Cbpa.2009.03.018  0.551
2009 Duschene KS, Veneziano SE, Silver SC, Broderick JB. Control of radical chemistry in the AdoMet radical enzymes. Current Opinion in Chemical Biology. 13: 74-83. PMID 19269883 DOI: 10.1016/J.Cbpa.2009.01.022  0.804
2009 Chandra T, Silver SC, Zilinskas E, Shepard EM, Broderick WE, Broderick JB. Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. Journal of the American Chemical Society. 131: 2420-1. PMID 19178276 DOI: 10.1021/Ja807375C  0.757
2008 Vey JL, Yang J, Li M, Broderick WE, Broderick JB, Drennan CL. Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 16137-41. PMID 18852451 DOI: 10.1073/Pnas.0806640105  0.493
2008 McGlynn SE, Shepard EM, Winslow MA, Naumov AV, Duschene KS, Posewitz MC, Broderick WE, Broderick JB, Peters JW. HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis. Febs Letters. 582: 2183-7. PMID 18501709 DOI: 10.1016/J.Febslet.2008.04.063  0.425
2007 Broderick JB. Assembling iron-sulfur clusters in the cytosol. Nature Chemical Biology. 3: 243-4. PMID 17438544 DOI: 10.1038/Nchembio0507-243  0.482
2007 McGlynn SE, Ruebush SS, Naumov A, Nagy LE, Dubini A, King PW, Broderick JB, Posewitz MC, Peters JW. In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 12: 443-7. PMID 17372774 DOI: 10.1007/S00775-007-0224-Z  0.449
2007 Nnyepi MR, Peng Y, Broderick JB. Inactivation of E. coli pyruvate formate-lyase: role of AdhE and small molecules. Archives of Biochemistry and Biophysics. 459: 1-9. PMID 17280641 DOI: 10.1016/J.Abb.2006.12.024  0.78
2006 Buis JM, Cheek J, Kalliri E, Broderick JB. Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily. The Journal of Biological Chemistry. 281: 25994-6003. PMID 16829680 DOI: 10.1074/Jbc.M603931200  0.852
2005 Walsby CJ, Ortillo D, Yang J, Nnyepi MR, Broderick WE, Hoffman BM, Broderick JB. Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily. Inorganic Chemistry. 44: 727-41. PMID 15859242 DOI: 10.1021/Ic0484811  0.807
2005 Buis JM, Broderick JB. Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation. Archives of Biochemistry and Biophysics. 433: 288-96. PMID 15581584 DOI: 10.1016/J.Abb.2004.09.028  0.872
2004 Broderick JB. Iron-Sulfur Clusters in Enzyme Catalysis Comprehensive Coordination Chemistry Ii. 8: 739-757. DOI: 10.1016/B0-08-043748-6/08214-1  0.459
2003 Cosper MM, Cosper NJ, Hong W, Shokes JE, Broderick WE, Broderick JB, Johnson MK, Scott RA. Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme. Protein Science : a Publication of the Protein Society. 12: 1573-7. PMID 12824504 DOI: 10.1110/Ps.0302203  0.64
2003 Broderick JB, Ortillo D, Broderick WE, Hong W, Walsby CJ, Hoffman BM, Krebs C, Hanh B. Poised for radical generation: Interaction of S-adenosylmethionine with a [4Fe4S] cluster Journal of Inorganic Biochemistry. 96: 104. DOI: 10.1016/S0162-0134(03)80571-8  0.816
2002 Walsby CJ, Ortillo D, Broderick WE, Broderick JB, Hoffman BM. An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme. Journal of the American Chemical Society. 124: 11270-1. PMID 12236732 DOI: 10.1021/Ja027078V  0.866
2002 Walsby CJ, Hong W, Broderick WE, Cheek J, Ortillo D, Broderick JB, Hoffman BM. Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme. Journal of the American Chemical Society. 124: 3143-51. PMID 11902903 DOI: 10.1021/Ja012034S  0.864
2002 Cheek J, Broderick JB. Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate. Journal of the American Chemical Society. 124: 2860-1. PMID 11902862 DOI: 10.1021/Ja017784G  0.471
2002 Krebs C, Broderick WE, Henshaw TF, Broderick JB, Huynh BH. Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study. Journal of the American Chemical Society. 124: 912-3. PMID 11829592 DOI: 10.1021/Ja017562I  0.86
2001 Cheek J, Broderick JB. Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 6: 209-26. PMID 11315557 DOI: 10.1007/S007750100210  0.628
2000 Miller JR, Busby RW, Jordan SW, Cheek J, Henshaw TF, Ashley GW, Broderick JB, Cronan JE, Marletta MA. Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein. Biochemistry. 39: 15166-78. PMID 11106496 DOI: 10.1021/Bi002060N  0.844
2000 Broderick JB, Henshaw TF, Cheek J, Wojtuszewski K, Smith SR, Trojan MR, McGhan RM, Kopf A, Kibbey M, Broderick WE. Pyruvate formate-lyase-activating enzyme: strictly anaerobic isolation yields active enzyme containing a [3Fe-4S](+) cluster. Biochemical and Biophysical Research Communications. 269: 451-6. PMID 10708574 DOI: 10.1006/Bbrc.2000.2313  0.858
2000 Krebs C, Henshaw TF, Cheek J, Huynh BH, Broderick JB. Conversion of 3Fe-4S to 4Fe-4S clusters in native pyruvate formate-lyase activating enzyme: Mössbauer characterization and implications for mechanism Journal of the American Chemical Society. 122: 12497-12506. DOI: 10.1021/Ja003335P  0.866
2000 Henshaw TF, Cheek J, Broderick JB. The [4fe-4s]1+ cluster of pyruvate formate-lyase activating enzyme generates the glycyl radical on pyruvate formate-lyase: EPR-detected single turnover [17] Journal of the American Chemical Society. 122: 8331-8332. DOI: 10.1021/Ja002012Q  0.862
1999 Broderick JB. Catechol dioxygenases. Essays in Biochemistry. 34: 173-89. PMID 10730195  0.408
1997 Broderick JB, Duderstadt RE, Fernandez DC, Wojtuszewski K, Henshaw TF, Johnson MK. Pyruvate formate-lyase activating enzyme is an iron-sulfur protein Journal of the American Chemical Society. 119: 7396-7397. DOI: 10.1021/Ja9711425  0.875
1994 Booker S, Licht S, Broderick J, Stubbe J. Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. Biochemistry. 33: 12676-85. PMID 7918494 DOI: 10.1021/Bi00208A019  0.767
1993 Broderick JB, Natan MJ, O'Halloran TV, Van Duyne RP. Evidence for retention of biological activity of a non-heme iron enzyme adsorbed on a silver colloid: a surface-enhanced resonance Raman scattering study. Biochemistry. 32: 13771-6. PMID 8268151 DOI: 10.1021/Bi00213A003  0.712
1993 Booker S, Broderick J, Stubbe J. Ribonucleotide reductases: Radical enzymes with suicidal tendencies Biochemical Society Transactions. 21: 727-730. PMID 8224499 DOI: 10.1042/Bst0210727  0.721
1991 Broderick JB, O'Halloran TV. Overproduction, purification, and characterization of chlorocatechol dioxygenase, a non-heme iron dioxygenase with broad substrate tolerance. Biochemistry. 30: 7349-58. PMID 1649626 DOI: 10.1021/Bi00243A040  0.684
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