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John C. Chaput, Ph.D. - Publications

Affiliations: 
Arizona State University, Tempe, AZ, United States 
 Havard Medical School, Boston, MA, United States 
 University of California, Riverside, Riverside, CA, United States 
Website:
http://www.faculty.uci.edu/profile.cfm?faculty_id=6145
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Year Citation  Score
2024 Tomar R, Ghodke PP, Patra A, Smyth E, Pontarelli A, Copp W, Guengerich FP, Chaput JC, Wilds CJ, Stone MP, Egli M. DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η. Biochemistry. PMID 39259676 DOI: 10.1021/acs.biochem.4c00387  0.301
2023 Majumdar B, Sarma D, Yu Y, Lozoya-Colinas A, Chaput JC. Increasing the functional density of threose nucleic acid. Rsc Chemical Biology. 5: 41-48. PMID 38179195 DOI: 10.1039/d3cb00159h  0.303
2023 Yik EJ, Maola VA, Chaput JC. Engineering TNA polymerases through iterative cycles of directed evolution. Methods in Enzymology. 691: 29-59. PMID 37914450 DOI: 10.1016/bs.mie.2023.04.014  0.323
2022 Hajjar M, Chim N, Liu C, Herdewijn P, Chaput JC. Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic Acids Research. 50: 9663-9674. PMID 36124684 DOI: 10.1093/nar/gkac792  0.375
2021 Li Q, Maola VA, Chim N, Hussain J, Lozoya-Colinas A, Chaput JC. Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities. Journal of the American Chemical Society. 143: 17761-17768. PMID 34637287 DOI: 10.1021/jacs.1c08649  0.304
2021 Medina E, Yik EJ, Herdewijn P, Chaput JC. Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology. Acs Synthetic Biology. PMID 34029459 DOI: 10.1021/acssynbio.1c00048  0.328
2020 Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW. Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization. Nucleic Acids Research. PMID 33347562 DOI: 10.1093/nar/gkaa1215  0.729
2020 Vallejo D, Nikoomanzar A, Chaput JC. Directed evolution of custom polymerases using droplet microfluidics. Methods in Enzymology. 644: 227-253. PMID 32943147 DOI: 10.1016/Bs.Mie.2020.04.056  0.401
2020 Zhang L, Chaput JC. In Vitro Selection of an ATP-Binding TNA Aptamer. Molecules (Basel, Switzerland). 25. PMID 32933142 DOI: 10.3390/Molecules25184194  0.476
2020 Nikoomanzar A, Chim N, Yik EJ, Chaput JC. Engineering polymerases for applications in synthetic biology. Quarterly Reviews of Biophysics. 53: e8. PMID 32715992 DOI: 10.1017/S0033583520000050  0.41
2020 Mei H, Wang Y, Yik EJ, Chaput JC. Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate. Biopolymers. e23388. PMID 32615644 DOI: 10.1002/Bip.23388  0.471
2020 Nikoomanzar A, Vallejo D, Yik E, Chaput JC. Programmed Allelic Mutagenesis of a DNA Polymerase with Single Amino Acid Resolution. Acs Synthetic Biology. PMID 32531152 DOI: 10.1021/Acssynbio.0C00236  0.396
2020 Dunn MR, McCloskey CM, Buckley P, Rhea K, Chaput JC. Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. Journal of the American Chemical Society. PMID 32298104 DOI: 10.1021/Jacs.0C00641  0.332
2019 Chaput JC, Wang Y, Vorperian A, Shehabat M. Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. Chembiochem : a European Journal of Chemical Biology. PMID 31680396 DOI: 10.1002/Cbic.201900596  0.408
2019 Bala S, Liao JY, Ngor AK, Yik E, Chaput JC. P(V) Reagents for the Scalable Synthesis of Natural and Modified Nucleoside Triphosphates. Journal of the American Chemical Society. PMID 31298849 DOI: 10.1021/Jacs.9B04728  0.344
2019 Chaput JC, Herdewijn P. What is XNA? Angewandte Chemie (International Ed. in English). PMID 31210402 DOI: 10.1002/Anie.201905999  0.362
2019 Jackson LN, Chim N, Shi C, Chaput JC. Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Nucleic Acids Research. PMID 31170294 DOI: 10.1093/nar/gkz513  0.353
2019 Wang Y, Yang J, Yuan X, Cao J, Xu J, Chaput JC, Li Z, Yu H. A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm. Scientific Reports. 9: 8224. PMID 31160698 DOI: 10.1038/S41598-019-44750-X  0.652
2019 Vallejo D, Nikoomanzar A, Paegel BM, Chaput JC. Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution. Acs Synthetic Biology. PMID 31120731 DOI: 10.1021/Acssynbio.9B00103  0.318
2019 Nikoomanzar A, Vallejo D, Chaput JC. Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning. Acs Synthetic Biology. PMID 31081325 DOI: 10.1021/Acssynbio.9B00104  0.396
2019 Horning DP, Bala S, Chaput JC, Joyce GF. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. Acs Synthetic Biology. PMID 31042360 DOI: 10.1021/Acssynbio.9B00044  0.427
2019 Mei H, Chaput J. Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue. Methods in Molecular Biology (Clifton, N.J.). 1973: 27-37. PMID 31016694 DOI: 10.1007/978-1-4939-9216-4_3  0.426
2019 McCloskey CM, Liao JY, Bala S, Chaput JC. Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates. Acs Synthetic Biology. PMID 30629885 DOI: 10.1021/Acssynbio.8B00511  0.458
2018 Lange MJ, Burke DH, Chaput JC. Activation of Innate Immune Responses by a Cytosine-Phosphate-Guanine Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid. Nucleic Acid Therapeutics. PMID 30526333 DOI: 10.1089/Nat.2018.0751  0.377
2018 Wang Y, Ngor AK, Nikoomanzar A, Chaput JC. Evolution of a General RNA-Cleaving FANA Enzyme. Nature Communications. 9: 5067. PMID 30498223 DOI: 10.1038/S41467-018-07611-1  0.374
2018 Juba AN, Chaput JC, Wellensiek BP. Exploring the Role of AUG Triplets in Human Cap-Independent Translation Enhancing Elements. Biochemistry. PMID 30371061 DOI: 10.1021/Acs.Biochem.8B00785  0.32
2018 Chim N, Jackson LN, Trinh AM, Chaput JC. Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife. 7. PMID 30338759 DOI: 10.7554/Elife.40444  0.42
2018 Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG. Bacterial Genome Containing Chimeric DNA-RNA Sequences. Journal of the American Chemical Society. PMID 30160955 DOI: 10.1021/Jacs.8B07046  0.322
2018 Bala S, Liao JY, Zhang L, Tran CN, Chim N, Chaput JC. Synthesis of 2'-Deoxy-α-L-Threofuranosyl Nucleoside Triphosphates. The Journal of Organic Chemistry. PMID 30011988 DOI: 10.1021/Acs.Joc.8B00875  0.429
2018 Mei H, Liao JY, Jimenez RM, Wang Y, Bala S, McCloskey C, Switzer C, Chaput JC. Synthesis and Evolution of a TNA Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. Journal of the American Chemical Society. PMID 29667819 DOI: 10.1021/Jacs.7B13031  0.721
2018 Chaput JC. Made in translation. Nature Chemistry. 10: 379-381. PMID 29568049 DOI: 10.1038/S41557-018-0034-7  0.405
2018 Mei H, Chaput JC. Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase. Chemical Communications (Cambridge, England). PMID 29340357 DOI: 10.1039/C7Cc09130C  0.343
2018 Feldman AW, Fischer EC, Ledbetter MP, Liao JY, Chaput JC, Romesberg FE. A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria. Journal of the American Chemical Society. PMID 29338214 DOI: 10.1021/Jacs.7B11404  0.378
2018 Chim N, Jackson LN, Trinh AM, Chaput JC. Author response: Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway Elife. DOI: 10.7554/Elife.40444.026  0.39
2018 Martinez SM, Kingston S, Ngor A, Chaput JC, Vinay NJ, Korch SB. Abstract 452: Direct delivery of a synthetic ATP binding protein reduces ATP and induces apoptosis in Hela cells Cancer Research. 78: 452-452. DOI: 10.1158/1538-7445.Am2018-452  0.338
2017 Chim N, Shi C, Sau SP, Nikoomanzar A, Chaput JC. Structural basis for TNA synthesis by an engineered TNA polymerase. Nature Communications. 8: 1810. PMID 29180809 DOI: 10.1038/S41467-017-02014-0  0.436
2017 Nikoomanzar A, Dunn MR, Chaput JC. Evaluating the Rate and Substrate Specificity of Laboratory Evolved XNA Polymerases. Analytical Chemistry. PMID 29148714 DOI: 10.1021/Acs.Analchem.7B03807  0.401
2017 Nikoomanzar A, Dunn MR, Chaput JC. Engineered Polymerases with Altered Substrate Specificity: Expression and Purification. Current Protocols in Nucleic Acid Chemistry. 69: 4.75.1-4.75.20. PMID 28628207 DOI: 10.1002/Cpnc.33  0.377
2017 Bala S, Liao JY, Mei H, Chaput JC. Synthesis of α-L-Threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-Methyl)imidazolides, and 3'-Triphosphates. The Journal of Organic Chemistry. PMID 28490177 DOI: 10.1021/Acs.Joc.7B00892  0.367
2017 Mei H, Shi C, Jimenez RM, Wang Y, Kardouh M, Chaput JC. Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue. Nucleic Acids Research. PMID 28472363 DOI: 10.1093/Nar/Gkx368  0.419
2016 Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. A Parallel Stranded G-Quadruplex Composed of Threose Nucleic Acid (TNA). Biopolymers. PMID 27718227 DOI: 10.1002/Bip.22999  0.381
2016 Dunn MR, Chaput JC. Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase. Chembiochem : a European Journal of Chemical Biology. PMID 27383648 DOI: 10.1002/Cbic.201600338  0.472
2016 Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. Structural Insights into Conformational Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem : a European Journal of Chemical Biology. PMID 27347671 DOI: 10.1002/Cbic.201600349  0.444
2016 Culbertson MC, Temburnikar KW, Sau SP, Liao JY, Bala S, Chaput JC. Evaluating TNA stability under simulated physiological conditions. Bioorganic & Medicinal Chemistry Letters. PMID 27080186 DOI: 10.1016/J.Bmcl.2016.03.118  0.398
2016 Larsen AC, Dunn MR, Hatch A, Sau SP, Youngbull C, Chaput JC. A general strategy for expanding polymerase function by droplet microfluidics. Nature Communications. 7: 11235. PMID 27044725 DOI: 10.1038/Ncomms11235  0.366
2016 Sau SP, Fahmi NE, Liao JY, Bala S, Chaput JC. A Scalable Synthesis of alpha-L-Threose Nucleic Acid Monomers. The Journal of Organic Chemistry. PMID 26895480 DOI: 10.1021/Acs.Joc.5B02768  0.738
2016 Dunn MR, Otto C, Fenton KE, Chaput JC. Improving Polymerase Activity with Unnatural Substrates by Sampling Mutations in Homologous Protein Architectures. Acs Chemical Biology. PMID 26860781 DOI: 10.1021/Acschembio.5B00949  0.443
2016 Anosova I, Kowal EA, Sisco NJ, Sau S, Liao J, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. Back Cover: Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes (ChemBioChem 18/2016) Chembiochem. 17: 1785-1785. DOI: 10.1002/Cbic.201600460  0.408
2015 Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. The structural diversity of artificial genetic polymers. Nucleic Acids Research. PMID 26673703 DOI: 10.1093/Nar/Gkv1472  0.372
2015 Dunn MR, Larsen AC, Zahurancik WJ, Fahmi NE, Meyers M, Suo Z, Chaput JC. DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription. Journal of the American Chemical Society. 137: 4014-7. PMID 25785966 DOI: 10.1021/Ja511481N  0.755
2014 Hartsough EM, Shah P, Larsen AC, Chaput JC. Comparative analysis of eukaryotic cell-free expression systems. Biotechniques. 59: 149-51. PMID 26345507 DOI: 10.2144/000114327  0.329
2014 Sau SP, Larsen AC, Chaput JC. Automated solid-phase synthesis of high capacity oligo-dT cellulose for affinity purification of poly-A tagged biomolecules. Bioorganic & Medicinal Chemistry Letters. 24: 5692-4. PMID 25467163 DOI: 10.1016/J.Bmcl.2014.10.065  0.348
2014 Dunn MR, Chaput JC. An In Vitro Selection Protocol for Threose Nucleic Acid (TNA) Using DNA Display. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 57: 9.8.1-9.8.19. PMID 24961723 DOI: 10.1002/0471142700.Nc0908S57  0.461
2014 Saul J, Petritis B, Sau S, Rauf F, Gaskin M, Ober-Reynolds B, Mineyev I, Magee M, Chaput J, Qiu J, LaBaer J. Development of a full-length human protein production pipeline. Protein Science : a Publication of the Protein Society. 23: 1123-35. PMID 24806540 DOI: 10.1002/Pro.2484  0.322
2013 Wellensiek BP, Larsen AC, Flores J, Jacobs BL, Chaput JC. A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells. Protein Science : a Publication of the Protein Society. 22: 1392-8. PMID 23908110 DOI: 10.1002/Pro.2325  0.379
2013 Zhang S, Yu H, Chaput JC. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.54. PMID 23512696 DOI: 10.1002/0471142700.Nc0454S52  0.659
2013 Yu H, Zhang S, Dunn MR, Chaput JC. An efficient and faithful in vitro replication system for threose nucleic acid Journal of the American Chemical Society. 135: 3583-3591. PMID 23432469 DOI: 10.1021/Ja3118703  0.659
2013 Zhang S, Chaput JC. Synthesis and enzymatic incorporation of α-l-threofuranosyl adenine triphosphate (tATP) Bioorganic and Medicinal Chemistry Letters. 23: 1447-1449. PMID 23352269 DOI: 10.1016/J.Bmcl.2012.12.080  0.457
2013 Korch SB, Stomel JM, León MA, Hamada MA, Stevenson CR, Simpson BW, Gujulla SK, Chaput JC. ATP sequestration by a synthetic ATP-binding protein leads to novel phenotypic changes in Escherichia coli. Acs Chemical Biology. 8: 451-63. PMID 23181457 DOI: 10.1021/Cb3004786  0.77
2013 Zhang S, Yu H, Chaput JC. Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension Current Protocols in Nucleic Acid Chemistry. DOI: 10.1002/0471142700.nc0454s52  0.58
2012 Chaput JC, Yu H, Zhang S. The emerging world of synthetic genetics Chemistry and Biology. 19: 1360-1371. PMID 23177191 DOI: 10.1016/J.Chembiol.2012.10.011  0.632
2012 Zhang S, Chaput JC. Synthesis of threose Nucleic Acid (TNA) phosphoramidite monomers and oligonucleotide polymers Current Protocols in Nucleic Acid Chemistry. PMID 22956457 DOI: 10.1002/0471142700.Nc0451S50  0.358
2012 Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions Angewandte Chemie - International Edition. 51: 7952-7955. PMID 22767484 DOI: 10.1002/Anie.201203459  0.644
2012 Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P. Synthetic genetic polymers capable of heredity and evolution. Science (New York, N.Y.). 336: 341-4. PMID 22517858 DOI: 10.1126/Science.1217622  0.406
2012 Yu H, Zhang S, Chaput JC. Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor Nature Chemistry. 4: 183-187. PMID 22354431 DOI: 10.1038/Nchem.1241  0.608
2011 Yu H, Jiang B, Chaput JC. Aptamers can discriminate alkaline proteins with high specificity Chembiochem. 12: 2659-2666. PMID 22021204 DOI: 10.1002/Cbic.201100252  0.709
2011 Liu R, Jiang B, Yu H, Chaput JC. Generating DNA Synbodies from Previously Discovered Peptides Chembiochem. 12: 1813-1817. PMID 21692159 DOI: 10.1002/Cbic.201100284  0.664
2010 Zhang J, Williams BA, Nilsson MT, Chaput JC. The evolvability of lead peptides from small library screens. Chemical Communications (Cambridge, England). 46: 7778-80. PMID 20830334 DOI: 10.1039/C0Cc01475C  0.705
2010 Williams BA, Chaput JC. Synthesis of peptide-oligonucleotide conjugates using a heterobifunctional crosslinker. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit4.41. PMID 20827717 DOI: 10.1002/0471142700.Nc0441S42  0.6
2010 Zhang S, Chaput JC. Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers Current Protocols in Nucleic Acid Chemistry. 4.40.1-4.40.18. PMID 20827716 DOI: 10.1002/0471142700.nc0440s42  0.306
2010 Simmons CR, Magee CL, Smith DA, Lauman L, Chaput JC, Allen JP. Three-dimensional structures reveal multiple ADP/ATP binding modes for a synthetic class of artificial proteins. Biochemistry. 49: 8689-99. PMID 20822107 DOI: 10.1021/Bi100398P  0.394
2010 McCullum EO, Williams BA, Zhang J, Chaput JC. Random mutagenesis by error-prone PCR. Methods in Molecular Biology (Clifton, N.J.). 634: 103-9. PMID 20676978 DOI: 10.1007/978-1-60761-652-8_7  0.74
2010 Zhang S, Switzer C, Chaput JC. The resurgence of acyclic nucleic acids Chemistry and Biodiversity. 7: 245-258. PMID 20151377 DOI: 10.1002/Cbdv.200900281  0.659
2009 Williams BA, Diehnelt CW, Belcher P, Greving M, Woodbury NW, Johnston SA, Chaput JC. Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds. Journal of the American Chemical Society. 131: 17233-41. PMID 19894711 DOI: 10.1021/Ja9051735  0.601
2009 Stomel JM, Wilson JW, Léon MA, Stafford P, Chaput JC. A man-made ATP-binding protein evolved independent of nature causes abnormal growth in bacterial cells Plos One. 4. PMID 19812699 DOI: 10.1371/Journal.Pone.0007385  0.765
2009 Stearns LA, Chhabra R, Sharma J, Liu Y, Petuskey WT, Yan H, Chaput JC. Template-directed nucleation and growth of inorganic nanoparticles on DNA scaffolds. Angewandte Chemie (International Ed. in English). 48: 8494-6. PMID 19795428 DOI: 10.1002/Anie.200903319  0.695
2009 Lin L, Fu Q, Williams BA, Azzaz AM, Shogren-Knaak MA, Chaput JC, Lindsay S. Recognition imaging of acetylated chromatin using a DNA aptamer. Biophysical Journal. 97: 1804-7. PMID 19751687 DOI: 10.1016/J.Bpj.2009.06.045  0.561
2009 Lin S, Horning DP, Szostak JW, Chaput JC. Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy Journal of Physical Chemistry A. 113: 9585-9587. PMID 19673467 DOI: 10.1021/Jp906746W  0.574
2009 Simmons CR, Stomel JM, McConnell MD, Smith DA, Watkins JL, Allen JP, Chaput JC. A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis. Acs Chemical Biology. 4: 649-58. PMID 19522480 DOI: 10.1021/Cb900109W  0.765
2009 McCullum EO, Chaput JC. Transcription of an RNA aptamer by a DNA polymerase Chemical Communications. 2938-2940. PMID 19436916 DOI: 10.1039/B820678C  0.416
2009 Williams BA, Lin L, Lindsay SM, Chaput JC. Evolution of a histone H4-K16 acetyl-specific DNA aptamer. Journal of the American Chemical Society. 131: 6330-1. PMID 19385619 DOI: 10.1021/Ja900916P  0.598
2009 Stearns LA, Chhabra R, Petuskey WT, Yan H, Chaput JC. Template-directed synthesis of self-assembled inorganic nanostructures Extended Abstracts For 6th Annual Conference On Foundations of Nanoscience: Self-Assembled Architectures and Devices, Fnano 2009. 89-92.  0.653
2008 Chaput JC, Woodbury NW, Stearns LA, Williams BA. Creating protein biocatalysts as tools for future industrial applications. Expert Opinion On Biological Therapy. 8: 1087-98. PMID 18613761 DOI: 10.1517/14712598.8.8.1087  0.746
2008 Watkins JL, Chaput JC. Searching combinatorial libraries for native proteins with novel folds Chembiochem. 9: 1361-1363. PMID 18464233 DOI: 10.1002/Cbic.200800147  0.346
2008 Zhang RS, McCullum EO, Chaput JC. Synthesis of two mirror image 4-helix junctions derived from glycerol nucleic acid. Journal of the American Chemical Society. 130: 5846-7. PMID 18407636 DOI: 10.1021/Ja800079J  0.452
2007 Yang YW, Zhang S, McCullum EO, Chaput JC. Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA. Journal of Molecular Evolution. 65: 289-95. PMID 17828568 DOI: 10.1007/S00239-007-9017-9  0.57
2007 Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. Journal of Molecular Biology. 371: 501-13. PMID 17583732 DOI: 10.1016/J.Jmb.2007.05.062  0.779
2007 Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC. Structural insights into the evolution of a non-biological protein: Importance of surface residues in protein fold optimization Plos One. 2. PMID 17520026 DOI: 10.1371/Journal.Pone.0000467  0.573
2007 Williams BA, Lund K, Liu Y, Yan H, Chaput JC. Self-assembled peptide nanoarrays: an approach to studying protein-protein interactions. Angewandte Chemie (International Ed. in English). 46: 3051-4. PMID 17361972 DOI: 10.1002/Anie.200603919  0.553
2005 Horhota A, Zou K, Ichida JK, Yu B, McLaughlin LW, Szostak JW, Chaput JC. Kinetic analysis of an efficient DNA-dependent TNA polymerase. Journal of the American Chemical Society. 127: 7427-34. PMID 15898792 DOI: 10.1021/Ja0428255  0.737
2004 Chaput JC, Szostak JW. Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability Chemistry and Biology. 11: 865-874. PMID 15217619 DOI: 10.1016/J.Chembiol.2004.04.006  0.569
2003 Chaput JC, Szostak JW. TNA synthesis by DNA polymerases Journal of the American Chemical Society. 125: 9274-9275. PMID 12889939 DOI: 10.1021/Ja035917N  0.611
2003 Chaput JC, Ichida JK, Szostak JW. DNA polymerase-mediated DNA synthesis on a TNA template. Journal of the American Chemical Society. 125: 856-7. PMID 12537469 DOI: 10.1021/Ja028589K  0.75
2002 Chaput JC, Sinha S, Switzer C. 5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chemical Communications (Cambridge, England). 1568-9. PMID 12170785 DOI: 10.1039/B204535D  0.755
2001 Switzer C, Chaput JC. Probing structure and function with alternative nucleic acids bearing 2′,5′-linked, zwitterionic, and isocytosine·isoguanine components Methods. 23: 141-148. PMID 11181033 DOI: 10.1006/Meth.2000.1115  0.666
2000 Chaput JC, Switzer C. Nonenzymatic oligomerization on templates containing phosphodiester-linked acyclic glycerol nucleic acid analogues Journal of Molecular Evolution. 51: 464-470. PMID 11080369 DOI: 10.1007/S002390010109  0.692
2000 Rice KP, Chaput JC, Cox MM, Switzer C. RecA protein promotes strand exchange with DNA substrates containing isoguanine and 5-methyl isocytosine Biochemistry. 39: 10177-10188. PMID 10956007 DOI: 10.1021/Bi0003339  0.701
2000 Chaput JC, Switzer C. Non-enzymatic transcription of an isoG·isoC base pair [2] Journal of the American Chemical Society. 122: 12866-12867. DOI: 10.1021/Ja002260M  0.586
1999 Chaput JC, Switzer C. A DNA pentaplex incorporating nucleobase quintets Proceedings of the National Academy of Sciences of the United States of America. 96: 10614-10619. PMID 10485874 DOI: 10.1073/Pnas.96.19.10614  0.677
1997 Roberts C, Chaput JC, Switzer C. Beyond guanine quartets: Cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine Chemistry and Biology. 4: 899-908. PMID 9427655 DOI: 10.1016/S1074-5521(97)90298-2  0.663
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