Christopher A. Klug - Publications

Affiliations: 
University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Microbiology Biology
Website:
http://apps.medicine.uab.edu/FacultyDirectory/FacultyData.asp?FID=4844

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bhalerao N, Chakraborty A, Marciel MP, Hwang J, Britain CM, Silva AD, Eltoum IE, Jones RB, Alexander KL, Smythies LE, Smith PD, Crossman DK, Crowley MR, Shin B, Harrington LE, ... ... Klug CA, et al. ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression. Jci Insight. PMID 37643018 DOI: 10.1172/jci.insight.161563  0.338
2018 Su H, Sun CW, Liu SM, He X, Hu H, Pawlik KM, Townes TM, Han X, Klug CA, Henary M, Chen Y, Li L, Zheng YG, Zhao X. Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1. Blood Advances. 2: 2829-2836. PMID 30373889 DOI: 10.1182/Bloodadvances.2018020727  0.453
2018 Chakraborty A, Jones RB, Klug CA, Smythies LE, Bellis SL. Abstract 4092: Glycosyltransferase ST6Gal-I promotes pancreatic ductal adenocarcinoma progression and metastasis Cancer Research. 78: 4092-4092. DOI: 10.1158/1538-7445.Am2018-4092  0.464
2017 Kim HG, LeGrand J, Swindle CS, Nick HJ, Oster RA, Chen D, Purohit-Ghelani S, Cotta CV, Ko R, Gartland L, Reddy V, Hiebert SW, Friedman AD, Klug CA. The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia. Leukemia. PMID 28751774 DOI: 10.1038/Leu.2017.236  0.747
2016 He Q, Swindle CS, Wan C, Flynn RJ, Oster RA, Chen D, Zhang F, Shu Y, Klug CA. Enhanced hematopoietic stem cell self-renewal-promoting ability of clonal primary MSC versus their osteogenic progeny. Stem Cells (Dayton, Ohio). PMID 27539014 DOI: 10.1002/Stem.2481  0.673
2016 Schultz MJ, Holdbrooks AT, Chakraborty A, Grizzle WE, Landen CN, Buchsbaum DJ, Conner MB, Arend RC, Yoon KJ, Klug C, Bullard DC, Kesterson RA, Oliver PG, O'Connor AK, Yoder BK, et al. The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype. Cancer Research. PMID 27216178 DOI: 10.1158/0008-5472.Can-15-2834  0.379
2016 Harbuzariu A, Daley-Brown DS, Harmon TL, Garrison RC, Beech DJ, Cason FD, Klug C, Gonzalez-Perez RR. Abstract B26: Leptin affects proliferation, stem cells and chemotherapeutic treatment outcome of pancreatic cancer: A link to health disparity Cancer Epidemiology, Biomarkers & Prevention. 25. DOI: 10.1158/1538-7755.Disp15-B26  0.358
2015 Gu Y, Jones AE, Yang W, Liu S, Dai Q, Liu Y, Swindle CS, Zhou D, Zhang Z, Ryan TM, Townes TM, Klug CA, Chen D, Wang H. The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699484 DOI: 10.1073/Pnas.1517041113  0.453
2015 Ludwig MR, Kojima K, Bowersock GJ, Chen D, Jhala NC, Buchsbaum DJ, Grizzle WE, Klug CA, Mobley JA. Surveying the serologic proteome in a tissue specific kras(G12D) knockin mouse model of pancreatic cancer. Proteomics. PMID 26572242 DOI: 10.1002/Pmic.201500133  0.537
2015 Gu Y, Yang W, Jones A, Liu S, Dai Q, Swindle CS, Ryan T, Townes TM, Klug C, Wang H. Regulation of Hematopoietic Stem Cell Function By the Histone H2A Deubiquitinase Usp16 Blood. 126: 1177-1177. DOI: 10.1182/blood.V126.23.1177.1177  0.353
2014 LeGrand JN, Heidemann SC, Swindle CS, Klug CA. Identification of Cytogenetically Normal Human CD34+CD38+ Hematopoietic Stem/Progenitor Cells from Inv(16)+ Leukemic Bone Marrow Blood. 124: 1059-1059. DOI: 10.1182/Blood.V124.21.1059.1059  0.368
2012 Kojima K, Bowersock GJ, Kojima C, Klug CA, Grizzle WE, Mobley JA. Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human. Proteomics. 12: 3393-402. PMID 22997103 DOI: 10.1002/Pmic.201100663  0.51
2012 Klug CA. GM-CSFRα: the sex-chromosome link to t(8;21)(+) AML? Blood. 119: 2976-7. PMID 22461472 DOI: 10.1182/Blood-2012-01-403691  0.319
2012 Nick HJ, Kim HG, Chang CW, Harris KW, Reddy V, Klug CA. Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia. Blood. 119: 1522-31. PMID 21937700 DOI: 10.1182/Blood-2011-02-338228  0.393
2012 Kolupaev O, Thal M, Klug C. C-Kit Signaling Blocks B Cell Differentiation of Common Lymphoid Progenitor Cells by Negatively Regulating Stat5-Dependent Activation of Ebf Expressionc-Kit Signaling Blocks B Cell Differentiation of Common Lymphoid Progenitor Cells by Negatively Regulating Stat5-Dependent Activation of Ebf1 Expression Blood. 120: 1209-1209. DOI: 10.1182/Blood.V120.21.1209.1209  0.807
2012 Lludwig MR, Kojima K, Jhala NC, Grizzle WE, Christein JD, Klug CA, Mobley JA. Abstract A7: Surveying the serum proteome for early-stage pancreatic neoplasia biomarkers using genetically engineered mouse models. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A7  0.529
2012 Ludwig MR, Kojima K, Grizzle W, Mobley JA, Klug CA. Abstract 4807: Identification of pre-invasive pancreatic cancer serum biomarkers using genetically engineered mouse models and mass spectrometry techniques Cancer Research. 72: 4807-4807. DOI: 10.1158/1538-7445.Am2012-4807  0.532
2011 Denning WL, Xu J, Guo S, Klug CA, Hel Z. Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses. Plos One. 6: e16897. PMID 21379572 DOI: 10.1371/Journal.Pone.0016897  0.417
2010 Coppersmith HJ, Kim H, Klug C. Differential Contributions of c-Kit Activating Mutations to Promotion of AML1-ETO Associated Neoplasia Blood. 116: 4195-4195. DOI: 10.1182/blood.v116.21.4195.4195  0.34
2009 Thal MA, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA. Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proceedings of the National Academy of Sciences of the United States of America. 106: 552-7. PMID 19122139 DOI: 10.1073/Pnas.0802550106  0.809
2009 Augustin L, Sorenson B, Wasiluk K, Frykman N, McCulloch K, Kojima K, Klug C, Saluja A, Vickers S, Saltzman D, Leonard A. QS147. Development of a Reproducible Syngeneic Orthotopic Model of Pancreatic Cancer in Immunocompetent C57BL/6 Mice Journal of Surgical Research. 151: 289. DOI: 10.1016/J.Jss.2008.11.445  0.52
2008 Kojima K, Asmellash S, Klug CA, Grizzle WE, Mobley JA, Christein JD. Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 12: 1683-90. PMID 18709425 DOI: 10.1007/S11605-008-0632-6  0.505
2008 Ko RM, Kim HG, Wolff L, Klug CA. Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia. Leukemia Research. 32: 1101-11. PMID 18037485 DOI: 10.1016/J.Leukres.2007.10.012  0.767
2008 Kim HG, Kojima K, Swindle CS, Cotta CV, Huo Y, Reddy V, Klug CA. FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia. Blood. 111: 1567-74. PMID 17967943 DOI: 10.1182/Blood-2006-06-030312  0.756
2008 Ballestas CS, Kim H, Swindle CS, Klug C. Identification of Leukemia Stem Cells Associated with AML1-ETO through Characterization of Oncogene-Induced Changes in Cell Surface Antigen Profiles on Hematopoietic Stem Cells. Blood. 112: 1357-1357. DOI: 10.1182/blood.V112.11.1357.1357  0.452
2008 Christein JD, Kojima K, Asmellash SG, Klug CA, Mobley JA. 559 Applying Proteomics Based Biomarker Tools for the Accurate Diagnosis of Pancreatic Cancer Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63977-3  0.481
2007 Kojima K, Vickers SM, Adsay NV, Jhala NC, Kim HG, Schoeb TR, Grizzle WE, Klug CA. Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia. Cancer Research. 67: 8121-30. PMID 17804724 DOI: 10.1158/0008-5472.Can-06-4167  0.558
2007 Zhang Z, Swindle CS, Bates JT, Ko R, Cotta CV, Klug CA. Expression of a non-DNA-binding isoform of Helios induces T-cell lymphoma in mice. Blood. 109: 2190-7. PMID 17110463 DOI: 10.1182/Blood-2005-01-031930  0.796
2006 Wang N, Kim HG, Cotta CV, Wan M, Tang Y, Klug CA, Cao X. TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability. The Embo Journal. 25: 1469-80. PMID 16525506 DOI: 10.1038/Sj.Emboj.7601037  0.684
2005 Moreno-Miralles I, Pan L, Keates-Baleeiro J, Durst-Goodwin K, Yang C, Kim HG, Thompson MA, Klug CA, Cleveland JL, Hiebert SW. The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia. The Journal of Biological Chemistry. 280: 40097-103. PMID 16199529 DOI: 10.1074/Jbc.M506855200  0.416
2004 Kim HG, de Guzman CG, Swindle CS, Cotta CV, Gartland L, Scott EW, Klug CA. The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells. Blood. 104: 3894-900. PMID 15328162 DOI: 10.1182/Blood-2002-08-2425  0.751
2004 Swindle CS, Kim HG, Klug CA. Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells. The Journal of Biological Chemistry. 279: 34-41. PMID 14559924 DOI: 10.1074/Jbc.M309128200  0.406
2004 Moreno I, Pan L, Keates J, Kim H, Klug C, Hiebert S. Establishment of a Retroviral Mouse Model for inv(16)-Mediated Acute Myeloid Leukemia Suggests That the p14ARF Tumor Suppressor Is a Transcriptional Target for Repression by the inv(16) Fusion Protein. Blood. 104: 547-547. DOI: 10.1182/Blood.V104.11.547.547  0.49
2004 Wang N, Wan M, Tang Y, Kim HG, Cotta C, Klug CA, Cao X. Smad4 Inhibits Nup98-Hoxa9 Transcriptional Activity by Interacting at Hox Homeodomain. Blood. 104: 2570-2570. DOI: 10.1182/Blood.V104.11.2570.2570  0.44
2003 Witt CM, Hurez V, Swindle CS, Hamada Y, Klug CA. Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Molecular and Cellular Biology. 23: 8637-50. PMID 14612407 DOI: 10.1128/Mcb.23.23.8637-8650.2003  0.66
2003 Purohit SJ, Stephan RP, Kim HG, Herrin BR, Gartland L, Klug CA. Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor. The Embo Journal. 22: 5511-21. PMID 14532123 DOI: 10.1093/Emboj/Cdg522  0.71
2003 Zhang Z, Cotta CV, Stephan RP, deGuzman CG, Klug CA. Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage. The Embo Journal. 22: 4759-69. PMID 12970188 DOI: 10.1093/Emboj/Cdg464  0.753
2003 Witt CM, Won WJ, Hurez V, Klug CA. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 2783-8. PMID 12960298 DOI: 10.4049/Jimmunol.171.6.2783  0.635
2003 de Guzman CG, Johnson A, Klug CA. The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo. Blood Cells, Molecules & Diseases. 30: 201-6. PMID 12732184 DOI: 10.1016/S1079-9796(03)00025-1  0.785
2003 Cotta CV, Zhang Z, Kim HG, Klug CA. Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development. Blood. 101: 4342-6. PMID 12560221 DOI: 10.1182/Blood-2002-10-3139  0.762
2002 Cotta CV, Weissman C, Weissman IL, Klug CA. Retroviral Transduction of FACS-Purified Hematopoietic Stem Cells. Methods in Molecular Medicine. 63: 243-52. PMID 21437812 DOI: 10.1385/1-59259-140-X:243  0.756
2002 Swindle CS, Klug CA. Mechanisms that regulate silencing of gene expression from retroviral vectors. Journal of Hematotherapy & Stem Cell Research. 11: 449-56. PMID 12183830 DOI: 10.1089/15258160260090915  0.344
2002 de Guzman CG, Warren AJ, Zhang Z, Gartland L, Erickson P, Drabkin H, Hiebert SW, Klug CA. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Molecular and Cellular Biology. 22: 5506-17. PMID 12101243 DOI: 10.1128/Mcb.22.15.5506-5517.2002  0.776
2002 Park IK, He Y, Lin F, Laerum OD, Tian Q, Bumgarner R, Klug CA, Li K, Kuhr C, Doyle MJ, Xie T, Schummer M, Sun Y, Goldsmith A, Clarke MF, et al. Differential gene expression profiling of adult murine hematopoietic stem cells. Blood. 99: 488-98. PMID 11781229 DOI: 10.1182/Blood.V99.2.488  0.577
2001 Park IK, Klug CA, Li K, Jerabek L, Lii L, Nanamori M, Neubig RR, Hoodi L, Weissman IL, Clarke MF. Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells Journal of Biological Chemistry. 276: 915-923. PMID 11042171 DOI: 10.1074/Jbc.M005947200  0.559
2000 Klug CA, Cheshier S, Weissman IL. Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny Blood. 96: 894-901. PMID 10910902 DOI: 10.1182/Blood.V96.3.894.015K35_894_901  0.708
1999 Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST. Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. Cold Spring Harbor Symposia On Quantitative Biology. 64: 87-97. PMID 11232341 DOI: 10.1101/Sqb.1999.64.87  0.319
1998 Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes & Development. 12: 782-96. PMID 9512513 DOI: 10.1101/Gad.12.6.782  0.552
1998 Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 95: 657-62. PMID 9435248 DOI: 10.1073/Pnas.95.2.657  0.689
1994 Klug CA, Gerety SJ, Shah PC, Chen YY, Rice NR, Rosenberg N, Singh H. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes Genes and Development. 8: 678-687. PMID 7926758 DOI: 10.1101/Gad.8.6.678  0.572
1993 Feldhaus AL, Klug CA, Arvin KL, Singh H. Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation Embo Journal. 12: 2763-2772. PMID 8334992 DOI: 10.1002/J.1460-2075.1993.Tb05937.X  0.608
1992 Feldhaus AL, Mbangkollo D, Arvin KL, Klug CA, Singh H. BLyF, a Novel Cell-Type- and Stage-Specific Regulator of the B-Lymphocyte Gene mb-1 Molecular and Cellular Biology. 12: 1126-1133. PMID 1545794 DOI: 10.1128/mcb.12.3.1126-1133.1992  0.635
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