Kishor M. Wasan - Publications

Affiliations: 
Pharmaceutical Sciences University of Saskatchewan, Saskatoon, SK, Canada 

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Høtoft Michaelsen M, Siqueira Jørgensen SD, Mahad Abdi I, Wasan KM, Rades T, Müllertz A. Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 31276759 DOI: 10.1016/J.Ejpb.2019.07.002  0.357
2019 Gordon JA, Noble JW, Midha A, Derakhshan F, Wang G, Adomat HH, Tomlinson Guns ES, Lin YY, Ren S, Collins CC, Nelson PS, Morrisey C, Wasan KM, Cox ME. Upregulation of Scavenger receptor B1 is required for steroidogenic and non-steroidogenic cholesterol metabolism in prostate cancer. Cancer Research. PMID 31064850 DOI: 10.1158/0008-5472.Can-18-2529  0.347
2016 Sassene PJ, Michaelsen MH, Mosgaard MD, Jensen MK, Van Den Broek E, Wasan KM, Mu H, Rades T, Müllertz A. In vivo precipitation of poorly soluble drugs from lipid based drug delivery systems. Molecular Pharmaceutics. PMID 27533712 DOI: 10.1021/Acs.Molpharmaceut.6B00413  0.324
2012 Wasan KM, Goss PE, Pritchard PH, Shepherd L, Tu D, Ingle JN. Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study. Breast Cancer Research and Treatment. 136: 769-76. PMID 23089983 DOI: 10.1007/S10549-012-2294-Z  0.398
2012 Lee SD, Gershkovich P, Darlington JW, Wasan KM. Inhibition of cholesterol absorption: targeting the intestine. Pharmaceutical Research. 29: 3235-50. PMID 22923351 DOI: 10.1007/S11095-012-0858-6  0.384
2012 Zhao J, Gershkovich P, Wasan KM. Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model. International Journal of Pharmaceutics. 436: 707-10. PMID 22850295 DOI: 10.1016/J.Ijpharm.2012.07.040  0.392
2012 Aikawa N, Okubo Y, Lynn M, Rossignol DP, Wong YN, Schuck E, Kitahara Y, Nakano T, Sivak O, Wasan KM, Nagy C, Yen M. Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men. Innate Immunity. 18: 793-803. PMID 22459966 DOI: 10.1177/1753425912441845  0.318
2012 Gershkovich P, Sivak O, Contreras-Whitney S, Darlington JW, Wasan KM. Assessment of cholesterol absorption inhibitors nanostructured aluminosilicate and cholestyramine using in vitro lipolysis model. Journal of Pharmaceutical Sciences. 101: 291-300. PMID 21935955 DOI: 10.1002/Jps.22770  0.409
2012 Fleischer JG, Rossignol D, Francis GA, Chan T, Lynn M, Wasan KM. Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins. Innate Immunity. 18: 171-8. PMID 21382909 DOI: 10.1177/1753425910394395  0.349
2012 Wasan KM, Cassidy SM, Kennedy AL, Peteherych KD. Lipoprotein isolation and analysis from serum by preparative ultracentrifugation. Methods in Molecular Medicine. 52: 27-35. PMID 21340929 DOI: 10.1385/1-59259-073-X:27  0.36
2011 Gershkovich P, Wasan KM, Sivak O, Lysakowski S, Reid C, Premalatha K, Werbovetz KA. Simultaneous determination of a novel antitrypanosomal compound (OSU-36) and its ester derivative (OSU-40) in plasma by HPLC: application to first pharmacokinetic study in rats. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, Sociã©Tã© Canadienne Des Sciences Pharmaceutiques. 14: 36-45. PMID 21501551 DOI: 10.18433/J3Cp4S  0.346
2011 Twiddy AL, Leon CG, Wasan KM. Cholesterol as a potential target for castration-resistant prostate cancer. Pharmaceutical Research. 28: 423-37. PMID 20683646 DOI: 10.1007/S11095-010-0210-Y  0.354
2010 Al Riyami N, Al-Ali AM, Al-Sarraf AJ, Hill J, Sachs-Barrable K, Hegele R, Wasan KM, Frohlich J. Hepatic lipase deficiency in a Middle-Eastern-Arabic male. Bmj Case Reports. 2010. PMID 22798447 DOI: 10.1136/Bcr.12.2009.2589  0.38
2010 Gershkovich P, Sivak O, Wasan EK, Magil AB, Owen D, Clement JG, Wasan KM. Biodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009). The Journal of Antimicrobial Chemotherapy. 65: 2610-3. PMID 20861140 DOI: 10.1093/Jac/Dkq358  0.35
2010 Gershkovich P, Sivak O, Sharma A, Barr AM, Procyshyn R, Wasan KM. Effect of hypertriglyceridemia on the pharmacokinetics and blood-brain barrier penetration of clozapine and norclozapine following administration to rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 545-52. PMID 20163937 DOI: 10.1016/J.Euroneuro.2010.01.002  0.317
2010 Leon CG, Locke JA, Adomat HH, Etinger SL, Twiddy AL, Neumann RD, Nelson CC, Guns ES, Wasan KM. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. The Prostate. 70: 390-400. PMID 19866465 DOI: 10.1002/Pros.21072  0.362
2010 Leon CG, Locke JA, Adomat H, Nelson CC, Twiddy AL, Neumann RD, Guns ES, Wasan KM. Abstract 5096: Alterations in cholesterol regulation contribute to the production of intratumoral androgens in castration-resistant prostate cancer Cancer Research. 70: 5096-5096. DOI: 10.1158/1538-7445.Am10-5096  0.355
2010 Leon CG, Midha A, Lee SD, Thornton SJ, Wasan KM. Abstract 3532: P-glycoprotein downregulation using RNAi decreases cholesterol efflux from human renal cancer cells Cancer Research. 70: 3532-3532. DOI: 10.1158/1538-7445.Am10-3532  0.418
2010 Al-Riyami NB, Ali AMA, Al-Sarraf AJ, Hill J, Hegele R, Sachs-Barrable K, Wasan KM, Frohlich J. Hepatic Lipase Deficiency in a Middle-Eastern/Arabic Male∗ Journal of Clinical Lipidology. 4: 226-227. DOI: 10.1016/J.Jacl.2010.03.065  0.386
2009 Sivak O, Darlington J, Gershkovich P, Constantinides PP, Wasan KM. Protonated nanostructured aluminosilicate (NSAS) reduces plasma cholesterol concentrations and atherosclerotic lesions in Apolipoprotein E deficient mice fed a high cholesterol and high fat diet. Lipids in Health and Disease. 8: 30. PMID 19638223 DOI: 10.1186/1476-511X-8-30  0.395
2009 Henderson RJ, Wasan KM, Leon CG. Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma. Lipids in Health and Disease. 8: 27. PMID 19627602 DOI: 10.1186/1476-511X-8-27  0.38
2009 Tory R, Sachs-Barrable K, Goshko CB, Hill JS, Wasan KM. Tacrolimus-induced elevation in plasma triglyceride concentrations after administration to renal transplant patients is partially due to a decrease in lipoprotein lipase activity and plasma concentrations. Transplantation. 88: 62-8. PMID 19584682 DOI: 10.1097/Tp.0B013E3181Aa7D04  0.437
2009 Wasan KM, Wasan EK, Gershkovich P, Zhu X, Tidwell RR, Werbovetz KA, Clement JG, Thornton SJ. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. The Journal of Infectious Diseases. 200: 357-60. PMID 19545212 DOI: 10.1086/600105  0.303
2009 Gershkovich P, Wasan EK, Lin M, Sivak O, Leon CG, Clement JG, Wasan KM. Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation. The Journal of Antimicrobial Chemotherapy. 64: 101-8. PMID 19398459 DOI: 10.1093/Jac/Dkp140  0.384
2009 Henderson RJ, Leon CG, Wasan KM. Differences in human phospholipid transfer protein activity following incubation of Fungizone compared to lipid-based Amphotericin-B formulations in normolipidemic and hyperlipidemic plasma. Drug Development and Industrial Pharmacy. 35: 1139-46. PMID 19381990 DOI: 10.1080/03639040902824852  0.384
2009 Thornton SJ, Wasan KM. The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis. Expert Opinion On Drug Delivery. 6: 271-84. PMID 19327044 DOI: 10.1517/17425240902802861  0.351
2009 Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z, Gagnon J, Gates B, Leon CG, Wasan KM. Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. International Journal of Pharmaceutics. 372: 76-84. PMID 19236839 DOI: 10.1016/J.Ijpharm.2009.01.003  0.36
2009 Gershkovich P, Darlington J, Sivak O, Constantinides PP, Wasan KM. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. Journal of Pharmaceutical Sciences. 98: 2390-400. PMID 19090562 DOI: 10.1002/Jps.21616  0.407
2009 Patel JP, Fleischer JG, Wasan KM, Brocks DR. The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine. Journal of Pharmaceutical Sciences. 98: 2516-28. PMID 18972574 DOI: 10.1002/Jps.21607  0.391
2009 Letchford K, Liggins R, Wasan KM, Burt H. In vitro human plasma distribution of nanoparticulate paclitaxel is dependent on the physicochemical properties of poly(ethylene glycol)-block-poly(caprolactone) nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 71: 196-206. PMID 18762253 DOI: 10.1016/J.Ejpb.2008.08.003  0.354
2009 Wasan KM. The biological functions of lipid excipients and the implications for pharmaceutical products development. Journal of Pharmaceutical Sciences. 98: 379-82. PMID 18484625 DOI: 10.1002/Jps.21435  0.304
2008 Gershkovich P, Wasan KM, Barta CA. A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery. Critical Reviews in Therapeutic Drug Carrier Systems. 25: 545-84. PMID 19166393 DOI: 10.1615/Critrevtherdrugcarriersyst.V25.I6.20  0.338
2008 Jia JX, Wasan KM. Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-D-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques. 11: 45-62. PMID 18801307 DOI: 10.18433/J33S3Z  0.36
2008 Barta CA, Sachs-Barrable K, Feng F, Wasan KM. Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers. Molecular Pharmaceutics. 5: 863-75. PMID 18651749 DOI: 10.1021/Mp800050Q  0.316
2008 Thornton SJ, Wong E, Lee SD, Wasan KM. Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism. Lipids in Health and Disease. 7: 21. PMID 18547429 DOI: 10.1186/1476-511X-7-21  0.419
2008 Tory R, Sachs-Barrable K, Hill JS, Wasan KM. Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma. International Journal of Pharmaceutics. 358: 219-23. PMID 18448283 DOI: 10.1016/J.Ijpharm.2008.03.026  0.412
2008 Porter CJ, Wasan KM, Constantinides P. Lipid-based systems for the enhanced delivery of poorly water soluble drugs. Advanced Drug Delivery Reviews. 60: 615-6. PMID 18160174 DOI: 10.1016/J.Addr.2007.10.009  0.322
2008 Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nature Reviews. Drug Discovery. 7: 84-99. PMID 18079757 DOI: 10.1038/Nrd2353  0.339
2008 Sachs-Barrable K, Lee SD, Wasan EK, Thornton SJ, Wasan KM. Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections. Advanced Drug Delivery Reviews. 60: 692-701. PMID 18053611 DOI: 10.1016/J.Addr.2007.08.042  0.374
2008 Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG. Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT). The Prostate. 68: 20-33. PMID 18000807 DOI: 10.1002/Pros.20674  0.338
2008 Wasan KM, Risovic V, Sivak O, Lee SD, Mason DX, Chiklis GR, McShane J, Lynn M, Wong N, Rossignol DP. Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits. Pharmaceutical Research. 25: 176-82. PMID 17849177 DOI: 10.1007/S11095-007-9428-8  0.43
2008 Leon C, Jia J, Qiu G, Hill JS, Wasan KM. Modifications in low-density lipoprotein receptor expression affects Cyclosporin A cellular uptake and cytotoxicity. Journal of Pharmaceutical Sciences. 97: 2350-61. PMID 17823952 DOI: 10.1002/Jps.21141  0.356
2008 Tory R, Sachs-Barrable K, Hill JS, Wasan KM. RAPAMYCIN DECREASES CHOLESTEROL EFFLUX AND ABCA1 PROTEIN EXPRESSION WITHIN THP-1 MACROPHAGES Transplantation. 86: 635. DOI: 10.1097/01.Tp.0000330946.72185.Ab  0.328
2008 Sachs-Barrable K, Lee SD, Wasan EK, Thornton SJ, Wasan KM. Corrigendum to "Enhancing drug absorption using lipids: A case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections" [Advanced Drug Delivery Reviews 60 (2008)692-701] (DOI:10.1016/j.addr.2007.08.042) Advanced Drug Delivery Reviews. 60: 1675. DOI: 10.1016/J.Addr.2008.09.003  0.384
2007 Rosland M, Szeto P, Procyshyn R, Barr AM, Wasan KM. Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography. Drug Development and Industrial Pharmacy. 33: 1158-66. PMID 17963117 DOI: 10.1080/03639040701484338  0.362
2007 Thornton SJ, Warburton C, Wasan KM, Kozlowski P. Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice. Drug Development and Industrial Pharmacy. 33: 1058-69. PMID 17963113 DOI: 10.1080/03639040601133746  0.352
2007 Risovic V, Rosland M, Sivak O, Wasan KM, Bartlett K. Assessing the antifungal activity of a new oral lipid-based amphotericin B formulation following administration to rats infected with Aspergillus fumigatus. Drug Development and Industrial Pharmacy. 33: 703-7. PMID 17654018 DOI: 10.1080/03639040601077349  0.388
2007 Stoodley R, Wasan KM, Bizzotto D. Fluorescence of amphotericin B-deoxycholate (fungizone) monomers and aggregates and the effect of heat-treatment. Langmuir : the Acs Journal of Surfaces and Colloids. 23: 8718-25. PMID 17637009 DOI: 10.1021/La7008573  0.584
2007 Shayeganpour A, Lee SD, Wasan KM, Brocks DR. The influence of hyperlipoproteinemia on in vitro distribution of amiodarone and desethylamiodarone in human and rat plasma. Pharmaceutical Research. 24: 672-8. PMID 17372694 DOI: 10.1007/S11095-006-9186-Z  0.334
2007 Dhanikula AB, Khalid NM, Lee SD, Yeung R, Risovic V, Wasan KM, Leroux JC. Long circulating lipid nanocapsules for drug detoxification. Biomaterials. 28: 1248-57. PMID 17125832 DOI: 10.1016/J.Biomaterials.2006.10.036  0.408
2007 Wasan KM, Sivak O, Rosland M, Risovic V, Bartlett K. Assessing the antifungal activity, pharmacokinetics, and tissue distribution of amphotericin B following the administration of Abelcet and AmBisome in combination with caspofungin to rats infected with Aspergillus fumigatus. Journal of Pharmaceutical Sciences. 96: 1737-47. PMID 17080414 DOI: 10.1002/Jps.20801  0.354
2006 Leon C, Sachs-Barrable K, Wasan KM. Does p-glycoprotein play a role in gastrointestinal absorption and cellular transport of dietary cholesterol? Drug Development and Industrial Pharmacy. 32: 779-82. PMID 16885132 DOI: 10.1080/03639040600559073  0.315
2006 Leon C, Wasan KM, Sachs-Barrable K, Johnston TP. Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression. Pharmaceutical Research. 23: 1597-607. PMID 16783477 DOI: 10.1007/S11095-006-0276-8  0.345
2006 Risovic V, Man D, Sivak O, Lee SD, Wasan KM. Assessing lipid lowering and plasma cholesteryl ester transfer protein activity of simvastatin following administration to rabbits fed a high fat/cholesterol diet. Drug Development and Industrial Pharmacy. 32: 609-15. PMID 16720415 DOI: 10.1080/03639040500529010  0.421
2006 Lee SD, Wasan KM, Calcagni A, Avery M, McCush F, Chen C. The in vitro plasma distribution of a novel cholesteryl ester transfer protein inhibitor, torcetrapib, is influenced by differences in plasma lipid concentrations. Pharmaceutical Research. 23: 1025-30. PMID 16715393 DOI: 10.1007/S11095-006-9908-2  0.417
2006 Patankar N, Wasan KM. Role of phospholipid transfer protein on the plasma distribution of amphotericin B following the incubation of different amphotericin B formulations. Pharmaceutical Research. 23: 1020-4. PMID 16715392 DOI: 10.1007/S11095-006-9900-X  0.392
2006 Johnston TP, Jaye M, Webb CL, Krawiec JA, Alom-Ruiz SP, Sachs-Barrable K, Wasan KM. Poloxamer 407 (P-407)-mediated reduction in the gene expression of ATP-binding-cassette transporter A1 may contribute to increased cholesterol in peripheral tissues of P-407-treated rats. European Journal of Pharmacology. 536: 232-40. PMID 16603153 DOI: 10.1016/J.Ejphar.2006.03.019  0.315
2006 Wasan KM, Wong JC, Corr T, Pritchard S. Role of plasma lipids and lipoproteins in predicting amphotericin B-induced nephrotoxicity in pediatric oncology patients. Cancer Chemotherapy and Pharmacology. 57: 120-4. PMID 16094544 DOI: 10.1007/S00280-005-0011-X  0.423
2005 Procyshyn RM, Ho T, Wasan KM. The effects of competitive displacement on haloperidol's plasma distribution in normolipidemic and hyperlipidemic plasma. Drug Development and Industrial Pharmacy. 31: 901-5. PMID 16306002 DOI: 10.1080/03639040500272058  0.353
2005 Leon C, Hill JS, Wasan KM. Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs. Pharmaceutical Research. 22: 1578-88. PMID 16180116 DOI: 10.1007/S11095-005-6306-0  0.448
2005 Procyshyn RM, Ho T, Wasan KM. Competitive displacement of clozapine from plasma proteins in normolipidemic and hyperlipidemic plasma samples: clinical implications. Drug Development and Industrial Pharmacy. 31: 331-7. PMID 16093198 DOI: 10.1081/Ddc-54305  0.332
2005 Leon C, Taylor R, Bartlett KH, Wasan KM. Effect of heat-treatment and the role of phospholipases on Fungizone-induced cytotoxicity within human kidney proximal tubular (HK-2) cells and Aspergillus fumigatus. International Journal of Pharmaceutics. 298: 211-8. PMID 15950412 DOI: 10.1016/J.Ijpharm.2005.04.018  0.318
2005 Wasan KM, Goss PE, Pritchard PH, Shepherd L, Palmer MJ, Liu S, Tu D, Ingle JN, Heath M, Deangelis D, Perez EA. The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L). Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 16: 707-15. PMID 15817595 DOI: 10.1093/Annonc/Mdi158  0.388
2005 Chung NS, Sachs-Barrable K, Lee SD, Wasan KM. Suitability of LLC-PK1 pig kidney cells for the study of drug action on renal cell cholesterol uptake: identification and characterization of low-density lipoprotein receptors. Journal of Pharmacological and Toxicological Methods. 51: 139-45. PMID 15767207 DOI: 10.1016/J.Vascn.2004.09.003  0.362
2005 Ng AW, Wasan KM, Lopez-Berestein G. Liposomal polyene antibiotics. Methods in Enzymology. 391: 304-13. PMID 15721388 DOI: 10.1016/S0076-6879(05)91017-3  0.364
2005 Sivak O, Lau B, Patankar N, Wasan KM. Unidirectional inhibition of lipid transfer protein I-mediated transfer of cholesteryl esters between high-density and low-density lipoproteins by amphotericin B lipid complex. Pharmaceutical Research. 21: 2336-9. PMID 15648266 DOI: 10.1007/S11095-004-7686-2  0.393
2005 Risovic V, Sachs-Barrable K, Boyd M, Wasan KM. Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B. Drug Development and Industrial Pharmacy. 30: 767-74. PMID 15491054 DOI: 10.1081/Ddc-120039793  0.327
2005 Sivak O, Bartlett K, Risovic V, Choo E, Marra F, Batty DS, Wasan KM. Assessing the antifungal activity and toxicity profile of amphotericin B lipid complex (ABLC; Abelcet) in combination with caspofungin in experimental systemic aspergillosis. Journal of Pharmaceutical Sciences. 93: 1382-9. PMID 15124198 DOI: 10.1002/Jps.20080  0.308
2004 Ng AW, Lukic T, Pritchard PH, Wasan KM. Development and characterization of liposomal disodium ascorbyl phytostanyl phosphates (FM-VP4). Drug Development and Industrial Pharmacy. 30: 739-58. PMID 15491052 DOI: 10.1081/Ddc-120039570  0.404
2004 Rossignol DP, Wasan KM, Choo E, Yau E, Wong N, Rose J, Moran J, Lynn M. Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers. Antimicrobial Agents and Chemotherapy. 48: 3233-40. PMID 15328078 DOI: 10.1128/Aac.48.9.3233-3240.2004  0.407
2004 Chung NS, Wasan KM. Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake. Advanced Drug Delivery Reviews. 56: 1315-34. PMID 15109771 DOI: 10.1016/J.Addr.2003.12.003  0.342
2004 Liang LS, Jackson J, Min W, Risovic V, Wasan KM, Burt HM. Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. Journal of Pharmaceutical Sciences. 93: 943-56. PMID 14999731 DOI: 10.1002/Jps.20031  0.301
2004 Bartlett K, Yau E, Hartsel SC, Hamer A, Tsai G, Bizzotto D, Wasan KM. Effect of heat-treated amphotericin B on renal and fungal cytotoxicity. Antimicrobial Agents and Chemotherapy. 48: 333-6. PMID 14693561 DOI: 10.1128/Aac.48.1.333-336.2004  0.608
2004 Risovic V, Boyd M, Choo E, Wasan KM. Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats. Antimicrobial Agents and Chemotherapy. 47: 3339-42. PMID 14506053 DOI: 10.1128/Aac.47.10.3339-3342.2003  0.408
2004 Kwong M, Wasan KM. Cyclosporine binds to the neutral lipid and potentially other binding sites of lipid transfer protein I. Pharmaceutical Research. 20: 1009-14. PMID 12880286 DOI: 10.1023/A:1024454105124  0.311
2004 Constantinides PP, Wasan KM. Advances in lipid-based drug solubilization and targeting Advanced Drug Delivery Reviews. 56: 1239-1240. DOI: 10.1016/J.Addr.2004.02.002  0.338
2003 Kim T, Callahan SM, Wasan KM, Brunner LJ. Effect of high-density lipoprotein associated cyclosporine on hepatic metabolism and renal function. Pda Journal of Pharmaceutical Science and Technology / Pda. 57: 341-50. PMID 14677627  0.321
2003 Subramanian R, Wasan KM. Effect of lipid excipients on in vitro pancreatic lipase activity. Drug Development and Industrial Pharmacy. 29: 885-90. PMID 14570309 DOI: 10.1081/Ddc-120024184  0.339
2003 Wasan KM, Sivak O, Cote RA, MacInnes AI, Boulanger KD, Lynn M, Christ WJ, Hawkins LD, Rossignol DP. Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: dependence on low-density and triglyceride-rich lipoprotein concentrations. Antimicrobial Agents and Chemotherapy. 47: 2796-803. PMID 12936976 DOI: 10.1128/Aac.47.9.2796-2803.2003  0.443
2003 Ng AW, Lukic T, Pritchard PH, Wasan KM. Development of novel water-soluble phytostanol analogs: disodium ascorbyl phytostanyl phosphates (FM-VP4): preclinical pharmacology, pharmacokinetics and toxicology. Cardiovascular Drug Reviews. 21: 151-68. PMID 12931251 DOI: 10.1111/J.1527-3466.2003.Tb00113.X  0.43
2003 Wasan KM, Yau E, Boulanger KD, Ramswamy M, Pritchard PH. Effects of disodium ascorbyl phytostanol phosphates (FM-VP4) on cholesterol accumulation within rat intestinal cells. Aaps Pharmsci. 5: E6. PMID 12713278 DOI: 10.1208/Ps050106  0.401
2003 Lukic T, Wasan KM, Zamfir D, Moghadasian MH, Pritchard PH. Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice. Metabolism: Clinical and Experimental. 52: 425-31. PMID 12701053 DOI: 10.1053/Meta.2003.50084  0.374
2003 Wasan KM, Sivak O. Modifications in lipoprotein surface charge alter cyclosporine A association with low-density lipoproteins. Pharmaceutical Research. 20: 126-9. PMID 12608546 DOI: 10.1023/A:1022215228799  0.347
2003 Wasan KM, Zamfir C, Pritchard PH, Pederson RA. Influence of phytostanol phosphoryl ascorbate (FM-VP4) on insulin resistance, hyperglycemia, plasma lipid levels, and gastrointestinal absorption of exogenous cholesterol in Zucker (fa/fa) fatty and lean rats. Journal of Pharmaceutical Sciences. 92: 281-8. PMID 12532378 DOI: 10.1002/Jps.10297  0.349
2003 Lundberg BB, Risovic V, Ramaswamy M, Wasan KM. A lipophilic paclitaxel derivative incorporated in a lipid emulsion for parenteral administration Journal of Controlled Release. 86: 93-100. PMID 12490375 DOI: 10.1016/S0168-3659(02)00323-1  0.403
2003 Procyshyn RM, Tsai G, Wasan KM. The influence of dyslipidemia on the plasma protein and lipoprotein distribution of haloperidol European Neuropsychopharmacology. 13: 33-37. PMID 12480120 DOI: 10.1016/S0924-977X(02)00078-0  0.434
2003 Wasan KM. The role of lymphatic transport in enhancing oral protein and peptide drug delivery. Drug Development and Industrial Pharmacy. 28: 1047-58. PMID 12455465 DOI: 10.1081/Ddc-120014573  0.322
2003 Kwong M, Wasan KM. Cholesteryl ester transfer protein facilitates the movement of water-insoluble drugs between lipoproteins: a novel biological function for a well-characterized lipid transfer protein. Biochemical Pharmacology. 64: 1669-75. PMID 12445856 DOI: 10.1016/S0006-2952(02)01392-8  0.455
2003 Brocks DR, Wasan KM. The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins. Journal of Pharmaceutical Sciences. 91: 1817-26. PMID 12115809 DOI: 10.1002/Jps.10182  0.441
2002 Wasan KM, Ramaswamy M, Kwong M, Boulanger KD. Role of plasma lipoproteins in modifying the toxic effects of water-insoluble drugs: studies with cyclosporine A Aaps Pharmsci [Electronic Resource]. 4: 30. PMID 12646002 DOI: 10.1208/Ps040430  0.433
2002 Wasan KM, Donnachie EM, Seccombe DW, Pritchard PH. Effect of cyclosporine A on the binding affinity and internalization of low-density lipoproteins in human skin fibroblasts. Journal of Pharmaceutical Sciences. 91: 2520-4. PMID 12434395 DOI: 10.1002/Jps.10249  0.384
2002 Stoodley R, Shepherd J, Wasan KM, Bizzotto D. Amphotericin B interactions with a DOPC monolayer. Electrochemical investigations. Biochimica Et Biophysica Acta. 1564: 289-97. PMID 12101024 DOI: 10.1016/S0005-2736(02)00463-7  0.639
2002 Wasan EK, Waterhouse D, Sivak O, Bally MB, Klasa RJ, Wasan KM. Plasma protein binding, lipoprotein distribution and uptake of free and lipid-associated BCL-2 antisense oligodeoxynucleotides (G3139) in human melanoma cells. International Journal of Pharmaceutics. 241: 57-64. PMID 12086721 DOI: 10.1016/S0378-5173(02)00131-X  0.408
2002 Amin K, Wasan KM, Albrecht RM, Heath TD. Cell association of liposomes with high fluid anionic phospholipid content is mediated specifically by LDL and its receptor, LDLr. Journal of Pharmaceutical Sciences. 91: 1233-44. PMID 11977099 DOI: 10.1002/Jps.10075  0.37
2002 Peteherych KD, Wasan KM. Effects of lipoproteins on cyclosporine A toxicity and uptake in LLC-PK1 pig kidney cells. Journal of Pharmaceutical Sciences. 90: 1395-406. PMID 11745792 DOI: 10.1002/Jps.1092  0.413
2002 Ramaswamy M, Wasan KM. Differences in the method by which plasma is separated from whole blood influences amphotericin B plasma recovery and distribution following amphotericin B lipid complex incubation within whole blood. Drug Development and Industrial Pharmacy. 27: 871-5. PMID 11699840 DOI: 10.1081/Ddc-100107252  0.361
2002 Hartsel SC, Bauer E, Kwong EH, Wasan KM. The effect of serum albumin on amphotericin B aggregate structure and activity. Pharmaceutical Research. 18: 1305-9. PMID 11683244 DOI: 10.1023/A:1013090011952  0.322
2001 Kwong M, Sivak O, Kwong EH, Wasan KM. Cyclosporine A transfer between high- and low-density lipoproteins: independent from lipid transfer protein I-facilitated transfer of lipoprotein-coated phospholipids because of high affinity of cyclosporine a for the protein component of lipoproteins. Journal of Pharmaceutical Sciences. 90: 1308-17. PMID 11745783 DOI: 10.1002/Jps.1083  0.473
2001 Wasan KM, Najafi S, Peteherych KD, Pritchard PH. Effects of a novel hydrophilic phytostanol analog on plasma lipid concentrations in gerbils. Journal of Pharmaceutical Sciences. 90: 1795-9. PMID 11745737 DOI: 10.1002/Jps.1129  0.454
2001 Wasan KM, Ramaswamy M, Holtorf L, Jayaraj AA, Hauss DJ. Rat and rabbit plasma distribution of free and chylomicron-associated BIRT 377, a novel small molecule antagonist of LFA-1-mediated cell adhesion. Pharmaceutical Research. 18: 510-9. PMID 11451039 DOI: 10.1023/A:1011062512712  0.334
2001 Wasan KM. Formulation and physiological and biopharmaceutical issues in the development of oral lipid-based drug delivery systems. Drug Development and Industrial Pharmacy. 27: 267-76. PMID 11411894 DOI: 10.1081/Ddc-100103726  0.383
2001 Kwong EH, Ramaswamy M, Bauer EA, Hartsel SC, Wasan KM. Heat treatment of amphotericin b modifies its serum pharmacokinetics, tissue distribution, and renal toxicity following administration of a single intravenous dose to rabbits. Antimicrobial Agents and Chemotherapy. 45: 2060-3. PMID 11408223 DOI: 10.1128/Aac.45.7.2060-2063.2001  0.374
2001 Procyshyn RM, Kennedy NB, Marriage S, Wasan KM. Plasma protein and lipoprotein distribution of clozapine. The American Journal of Psychiatry. 158: 949-51. PMID 11384905 DOI: 10.1176/Appi.Ajp.158.6.949  0.357
2001 Ramaswamy M, Peteherych KD, Kennedy AL, Wasan KM. Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities. Antimicrobial Agents and Chemotherapy. 45: 1184-91. PMID 11257033 DOI: 10.1128/Aac.45.4.1184-1191.2001  0.45
2001 Hartsel SC, Baas B, Bauer E, Foree LT, Kindt K, Preis H, Scott A, Kwong EH, Ramaswamy M, Wasan KM. Heat-induced superaggregation of amphotericin B modifies its interaction with serum proteins and lipoproteins and stimulation of TNF-alpha. Journal of Pharmaceutical Sciences. 90: 124-33. PMID 11169529 DOI: 10.1002/1520-6017(200102)90:2<124::Aid-Jps3>3.0.Co;2-X  0.42
2001 Wasan KM, Holtorf L, Subramanian R, Cassidy SM, Pritchard PH, Stewart DJ, Novak E, Moghadasian MH. Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats. Journal of Pharmaceutical Sciences. 90: 23-8. PMID 11064375 DOI: 10.1002/1520-6017(200101)90:1<23::Aid-Jps3>3.0.Co;2-P  0.407
2000 Brocks DR, Ramaswamy M, MacInnes AI, Wasan KM. The stereoselective distribution of halofantrine enantiomers within human, dog, and rat plasma lipoproteins. Pharmaceutical Research. 17: 427-31. PMID 10870986 DOI: 10.1023/A:1007524919865  0.386
2000 Rose JR, Mullarkey MA, Christ WJ, Hawkins LD, Lynn M, Kishi Y, Wasan KM, Peteherych K, Rossignol DP. Consequences of interaction of a lipophilic endotoxin antagonist with plasma lipoproteins. Antimicrobial Agents and Chemotherapy. 44: 504-10. PMID 10681310 DOI: 10.1128/Aac.44.3.504-510.2000  0.44
1999 Kennedy AL, Wasan KM. Preferential distribution of amphotericin B lipid complex into human HDL3 is a consequence of high density lipoprotein coat lipid content. Journal of Pharmaceutical Sciences. 88: 1149-55. PMID 10564063 DOI: 10.1021/Js990101Z  0.482
1999 Wasan KM, Strobel FW, Parrott SC, Lynn M, Christ WJ, Hawkins LD, Rossignol DP. Lipoprotein distribution of a novel endotoxin antagonist, E5531, in plasma from human subjects with various lipid levels. Antimicrobial Agents and Chemotherapy. 43: 2562-4. PMID 10508046 DOI: 10.1128/Aac.43.10.2562  0.437
1999 Wasan KM, Subramanian R, Chou JW, Ramaswamy M, Pritchard PH. Cyclosporine transfer from low- and high-density lipoproteins is partially influenced by lipid transfer protein I triglyceride transfer activity. Pharmaceutical Research. 16: 1067-73. PMID 10450932 DOI: 10.1023/A:1018991917799  0.383
1999 Ramaswamy M, Wallace TL, Cossum PA, Wasan KM. Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma. Antimicrobial Agents and Chemotherapy. 43: 1424-8. PMID 10348764 DOI: 10.1128/Aac.43.6.1424  0.457
1999 McIntosh MP, Porter CJ, Wasan KM, Ramaswamy M, Charman WN. Differences in the lipoprotein binding profile of halofantrine in fed and fasted human or beagle plasma are dictated by the respective masses of core apolar lipoprotein lipid. Journal of Pharmaceutical Sciences. 88: 378-84. PMID 10052998 DOI: 10.1021/Js980152G  0.446
1999 Wasan KM, Ramaswamy M, McIntosh MP, Porter CJ, Charman WN. Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: in vitro studies in normolipidemic and dyslipidemic human plasmas. Journal of Pharmaceutical Sciences. 88: 185-90. PMID 9950636 DOI: 10.1021/Js980353K  0.457
1999 Wasan KM, Cassidy SM, Ramaswamy M, Kennedy A, Strobel FW, Ng SP, Lee TY. A comparison of step-gradient and sequential density ultracentrifugation and the use of lipoprotein deficient plasma controls in determining the plasma lipoprotein distribution of lipid-associated nystatin and cyclosporine. Pharmaceutical Research. 16: 165-9. PMID 9950297 DOI: 10.1023/A:1011951602894  0.425
1999 Wasan KM, Kennedy AL, Cassidy SM, Ramaswamy M, Holtorf L, Chou JW, Pritchard PH. Pharmacokinetics, distribution in serum lipoproteins and tissues, and renal toxicities of amphotericin B and amphotericin B lipid complex in a hypercholesterolemic rabbit model: single-dose studies. Antimicrobial Agents and Chemotherapy. 42: 3146-52. PMID 9835506 DOI: 10.1128/Aac.42.12.3146  0.441
1998 Wasan KM, Ng SP, Wong W, Rodrigues BB. Streptozotocin- and alloxan-induced diabetes modifies total plasma and lipoprotein lipid concentration and composition without altering cholesteryl ester transfer activity. Pharmacology & Toxicology. 83: 169-75. PMID 9820878 DOI: 10.1111/J.1600-0773.1998.Tb01464.X  0.385
1998 Cassidy SM, Strobel FW, Wasan KM. Plasma lipoprotein distribution of liposomal nystatin is influenced by protein content of high-density lipoproteins. Antimicrobial Agents and Chemotherapy. 42: 1878-88. PMID 9687378 DOI: 10.1128/Aac.42.8.1878  0.439
1998 Wasan KM, Ramaswamy M, Ng SP, Wong W, Parrott SC, Ojwang JO, Wallace T, Cossum PA. Differences in the lipoprotein distribution of free and liposome-associated all-trans-retinoic acid in human, dog, and rat plasma are due to variations in lipoprotein lipid and protein content. Antimicrobial Agents and Chemotherapy. 42: 1646-53. PMID 9660998 DOI: 10.1128/Aac.42.7.1646  0.422
1998 Wasan KM, Cassidy SM. Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs. Journal of Pharmaceutical Sciences. 87: 411-24. PMID 9548892 DOI: 10.1021/Js970407A  0.416
1998 Wasan KM, Pritchard PH, Ramaswamy M, Wong W, Donnachie EM, Brunner LJ. Differences in lipoprotein lipid concentration and composition modify the plasma distribution of cyclosporine. Pharmaceutical Research. 14: 1613-20. PMID 9434283 DOI: 10.1023/A:1012190620854  0.423
1997 Wasan KM, Ramaswamy M, Cassidy SM, Kazemi M, Strobel FW, Thies RL. Physical characteristics and lipoprotein distribution of liposomal nystatin in human plasma. Antimicrobial Agents and Chemotherapy. 41: 1871-5. PMID 9303376 DOI: 10.1128/Aac.41.9.1871  0.406
1997 Wasan KM, Ramaswamy M, Haley J, Dunn BP. Administration of long-term tamoxifen therapy modifies the plasma lipoprotein-lipid concentration and lipid transfer protein I activity in postmenopausal women with breast cancer. Journal of Pharmaceutical Sciences. 86: 876-9. PMID 9232532 DOI: 10.1021/Js970097W  0.382
1997 Wasan KM, Ng S, Cassidy SM. Modifications in high-density lipoprotein lipid composition and structure alter the plasma distribution of free and liposomal annamycin. Journal of Pharmaceutical Sciences. 86: 872-5. PMID 9232531 DOI: 10.1021/Js960495J  0.45
1997 Wasan KM, Kwong M. Blood and plasma lipoprotein distribution and gender differences in the plasma pharmacokinetics of lipid-associated annamycin. Pharmacology & Toxicology. 80: 301-7. PMID 9225368 DOI: 10.1111/J.1600-0773.1997.Tb01978.X  0.405
1997 Ramaswamy M, Zhang X, Burt HM, Wasan KM. Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers. Journal of Pharmaceutical Sciences. 86: 460-4. PMID 9109049 DOI: 10.1021/Js960333N  0.424
1997 Wasan KM, Lopez-Berestein G. Diversity of lipid-based polyene formulations and their behavior in biological systems. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 16: 81-92. PMID 9063678 DOI: 10.1007/Bf01575125  0.491
1997 Wasan KM, Conklin JS. Enhanced amphotericin B nephrotoxicity in intensive care patients with elevated levels of low-density lipoprotein cholesterol. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 24: 78-80. PMID 8994768 DOI: 10.1093/Clinids/24.1.78  0.364
1997 Wasan KM, Lopez-Berestein G. Characteristics of lipid-based formulations that influence their biological behavior in the plasma of patients. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 23: 1126-38. PMID 8922813 DOI: 10.1093/Clinids/23.5.1126  0.436
1997 Wasan KM. Modifications in plasma lipoprotein concentration and lipid composition regulate the biological activity of hydrophobic drugs. Journal of Pharmacological and Toxicological Methods. 36: 1-11. PMID 8872913 DOI: 10.1016/1056-8719(96)00054-8  0.468
1996 Wasan KM, Morton RE. Differences in lipoprotein concentration and composition modify the plasma distribution of free and liposomal annamycin. Pharmaceutical Research. 13: 462-8. PMID 8692743 DOI: 10.1023/A:1016065114515  0.303
1996 Sugarman SM, Zou Y, Wasan K, Poirot K, Kumi R, Reddy S, Perez-Soler R. Lipid-complexed camptothecin: formulation and initial biodistribution and antitumor activity studies. Cancer Chemotherapy and Pharmacology. 37: 531-8. PMID 8612306 DOI: 10.1007/S002800050425  0.381
1996 Wasan KM, Perez-Soler R. Distribution of free and liposomal annamycin within human plasma is regulated by plasma triglyceride concentrations but not by lipid transfer protein. Journal of Pharmaceutical Sciences. 84: 1094-100. PMID 8537888 DOI: 10.1002/jps.2600840912  0.328
1995 Wasan KM, Grossie VB, Lopez-Berestein G. Concentrations in serum and distribution in tissue of free and liposomal amphotericin B in rats during continuous intralipid infusion. Antimicrobial Agents and Chemotherapy. 38: 2224-6. PMID 7811055 DOI: 10.1128/Aac.38.9.2224  0.358
1995 Wasan KM, Lopez-Berestein G. The interaction of liposomal amphotericin B and serum lipoproteins within the biological milieu. Journal of Drug Targeting. 2: 373-80. PMID 7704481 DOI: 10.3109/10611869408996812  0.432
1995 Wasan KM, Lopez-Berestein G. Targeted liposomes in fungi: Modifying the therapeutic index of amphotericin b by its incorporation into negatively charged liposomes Journal of Liposome Research. 5: 883-903. DOI: 10.3109/08982109509012689  0.378
1994 Wasan KM, Rosenblum MG, Cheung L, Lopez-Berestein G. Influence of lipoproteins on renal cytotoxicity and antifungal activity of amphotericin B. Antimicrobial Agents and Chemotherapy. 38: 223-7. PMID 8192447 DOI: 10.1128/Aac.38.2.223  0.391
1994 Wasan KM, Morton RE, Rosenblum MG, Lopez-Berestein G. Decreased toxicity of liposomal amphotericin B due to association of amphotericin B with high-density lipoproteins: role of lipid transfer protein. Journal of Pharmaceutical Sciences. 83: 1006-10. PMID 7965656 DOI: 10.1002/Jps.2600830716  0.418
1993 Wasan KM, Brazeau GA, Keyhani A, Hayman AC, Lopez-Berestein G. Roles of liposome composition and temperature in distribution of amphotericin B in serum lipoproteins. Antimicrobial Agents and Chemotherapy. 37: 246-50. PMID 8452354 DOI: 10.1128/Aac.37.2.246  0.422
1990 Luke DR, Wasan KM, McQueen TJ, Lopez-Berestein G. Enhancement of the treatment of experimental candidiasis with vascular decongestants. The Journal of Infectious Diseases. 162: 211-4. PMID 2355196 DOI: 10.1093/Infdis/162.1.211  0.314
1990 Wasan KM, Vadiei K, Lopez-Berestein G, Verani RR, Luke DR. Pentoxifylline in amphotericin B toxicity rat model. Antimicrobial Agents and Chemotherapy. 34: 241-4. PMID 2327772 DOI: 10.1128/Aac.34.2.241  0.301
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