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Jessica S. Fortin, BPharm, BSc, MSc, DVM, PhD - Publications

Affiliations: 
2018-2021 Pathobiology and Diagnostic Investigation Michigan State University, East Lansing, MI 
 2021- Basic Medical Sciences Purdue University, West Lafayette, IN, United States 
Area:
Medicinal chemistry, Protein misfolding and neurodegenerative diseases
Website:
https://vet.purdue.edu/directory/person.php?id=1635
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & Medicinal Chemistry. 100: 117613. PMID 38330847 DOI: 10.1016/j.bmc.2024.117613  0.837
2023 Ganegamage SK, Ramirez E, Alnakhala H, Tripathi A, Nguyen CCD, Zami A, Ostafe R, Tian S, Dettmer U, Fortin JS. 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation . Acs Omega. 9: 1216-1229. PMID 38222653 DOI: 10.1021/acsomega.3c07453  0.787
2023 Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, ... ... Fortin JS, et al. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation Acs Chemical Neuroscience. 14: 3913-3927. PMID 37818657 DOI: 10.1021/acschemneuro.3c00464  0.415
2023 Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, ... ... Fortin JS, et al. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation. Acs Chemical Neuroscience. PMID 37818657 DOI: 10.1021/acschemneuro.3c00464  0.769
2023 Horgan NG, Moore KBE, Fortin JS. Investigation of serum amyloid A within animal species focusing on the 1-25 amino acid region. The Veterinary Quarterly. 1-10. PMID 37800590 DOI: 10.1080/01652176.2023.2267605  0.37
2023 Ramirez E, Min S, Ganegamage SK, Shimanaka K, Sosa MG, Dettmer U, Rochet JC, Fortin JS. Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation. Results in Chemistry. 5. PMID 37346091 DOI: 10.1016/j.rechem.2023.100938  0.805
2023 Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS. 5-Nitro-1,2-benzothiazol-3-amine and -Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation. Acs Omega. 8: 20102-20115. PMID 37305264 DOI: 10.1021/acsomega.3c02668  0.745
2023 Moore KBE, Hung TJ, Fortin JS. Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies. Drug Discovery Today. 28: 103487. PMID 36634842 DOI: 10.1016/j.drudis.2023.103487  0.563
2022 Fortin JS, Shimanaka K, Saraswati AP, Liu M, Wang KW, Hagar HT, Maity S, Ganegamage SK, Ellsworth E, Counts SE, Borhan B, Dettmer U, Kuo MH. Anti-fibrillization effects of sulfonamide derivatives on -synuclein and hyperphosphorylated tau isoform 1N4R. Journal of Molecular Structure. 1267. PMID 36310922 DOI: 10.1016/j.molstruc.2022.133574  0.777
2022 Smith AA, Moore KBE, Ambs PM, Saraswati AP, Fortin JS. Recent Advances in the Discovery of Therapeutics to Curtail Islet Amyloid Polypeptide Aggregation for Type 2 Diabetes Treatment. Advanced Biology. e2101301. PMID 35931462 DOI: 10.1002/adbi.202101301  0.496
2022 Haines MS, Ramirez E, Moore KBE, Fortin JS. Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region. Biochemistry and Biophysics Reports. 31: 101284. PMID 35664543 DOI: 10.1016/j.bbrep.2022.101284  0.754
2022 Fortin JS, Shimanaka K, Saraswati AP, Liu M, Wang KW, Hagar HT, Maity S, Ganegamage SK, Ellsworth E, Counts SE, Borhan B, Dettmer U, Kuo MH. Anti-fibrillization effects of sulfonamide derivatives on α-synuclein and hyperphosphorylated tau isoform 1N4R Journal of Molecular Structure. 1267. DOI: https://doi.org/10.1016/j.molstruc.2022.133574  0.594
2021 Fortin JS, Hetak AA, Duggan KE, Burglass CM, Penticoff HB, Schott HC. Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy. Scientific Reports. 11: 16036. PMID 34362943 DOI: 10.1038/s41598-021-95396-7  0.525
2021 Penticoff HB, Hipkiss HK, Hetak AA, Agnew DW, Fortin JS. Survey of amyloidosis cases among different free-living wild and zoo animals. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-8. PMID 34132151 DOI: 10.1080/13506129.2021.1940931  0.408
2021 Fortin JS, Hakim CH, Korte S, Yang NN, Fitzgerald SD, Johnson GC, Smith BF, Duan D. Widespread severe myodegeneration in a compound heterozygote female dog with dystrophin deficiency. Veterinary Medicine and Science. PMID 33502125 DOI: 10.1002/vms3.433  0.239
2020 Glaspell SJ, Knapek KJ, Washington IM, Fitzgerald SD, Fortin JS. Nephroblastoma in a Sprague Dawley rat unrelated to titanium dioxide nanoparticle exposure in utero. Veterinary Medicine and Science. PMID 33277974 DOI: 10.1002/vms3.405  0.192
2020 Chlipala EA, Butters M, Brous M, Fortin JS, Archuletta R, Copeland K, Bolon B. Impact of Preanalytical Factors During Histology Processing on Section Suitability for Digital Image Analysis. Toxicologic Pathology. 49: 755-772. PMID 33251977 DOI: 10.1177/0192623320970534  0.232
2020 Fortin JS, Benskey MJ, Lookingland KJ, Patterson JS, Howey EB, Goudreau JL, Schott HC. Restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction. Bmc Veterinary Research. 16: 356. PMID 32977825 DOI: 10.1186/s12917-020-02565-3  0.219
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, ... ... Fortin J, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Molecular Neurobiology. PMID 32780352 DOI: 10.1007/S12035-020-02034-W  0.826
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, ... ... Fortin J, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Mol Neurobiol. PMID 32780352 DOI: 10.1007/s12035-020-02034-w  0.604
2020 Yin JH, Fortin JS. Pathology in Practice. Journal of the American Veterinary Medical Association. 256: 431-434. PMID 31999512 DOI: 10.2460/javma.256.4.431  0.258
2020 Fortin JS, Benskey MJ, Lookingland KJ, Patterson JS, Howey EB, Goudreau JL, Schott II HC. Restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction Bmc Veterinary Research. DOI: 10.1186/s12917-020-02565-3  0.206
2020 Fortin JS, Isa NB, Rashid AM, Thompson TL, O’Dell M. Small molecules breaking down islet amyloid polypeptide self‐assembly The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08776  0.471
2020 Fortin JS, Isa NBM, Rashid AM, Thompson TL, O’Dell M. Design of Small Molecules to Modulate Transthyretin Aggregation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02641  0.428
2019 Fortin JS, Chlipala EA, Shaw DP, Bolon B. Methods Optimization for Routine Sciatic Nerve Processing in General Toxicity Studies. Toxicologic Pathology. 192623319850774. PMID 31117891 DOI: 10.1177/0192623319850774  0.311
2018 Fortin JS, Royal AB, Kuroki K. Concurrent thoracic mesothelioma and thyroid C-cell adenoma with amyloid deposition in an aged horse. Veterinary Medicine and Science. 4: 63-70. PMID 29468082 DOI: 10.1002/vms3.87  0.31
2018 Fortin JS, Shomper J, Williams F, Royal AB. What is your diagnosis? Nasopharyngeal mass in a mixed breed dog. Veterinary Clinical Pathology. PMID 29438573 DOI: 10.1111/Vcp.12589  0.295
2017 Fortin JS, Calcutt MJ, Kim DY. Sublingual pythiosis in a cat. Acta Veterinaria Scandinavica. 59: 63. PMID 28950884 DOI: 10.1186/S13028-017-0330-Z  0.322
2017 Fortin JS, Calcutt MJ, Kim DY.. Sublingual pythiosis in a cat. Acta Vet Scand. 59: 63. PMID 28950884 DOI: 10.1186/s13028-017-0330-z  0.213
2017 Fortin JS, Calcutt MJ, Nagy DW, Kuroki K. INTESTINAL HISTOPLASMOSIS IN A CAPTIVE REINDEER (RANGIFER TARANDUS), MISSOURI, USA. Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians. 48: 925-928. PMID 28920817 DOI: 10.1638/2016-0246.1  0.32
2016 Fortin JS, Benoit-Biancamano MO, C-Gaudreault R. Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity. Canadian Journal of Physiology and Pharmacology. 94: 341-6. PMID 26679837 DOI: 10.1139/Cjpp-2015-0204  0.586
2016 Fortin JS, Benoit-Biancamano MO. Inhibition of islet amyloid polypeptide aggregation and associated cytotoxicity by nonsteroidal anti-inflammatory drugs. Canadian Journal of Physiology and Pharmacology. 94: 35-48. PMID 26524404 DOI: 10.1139/Cjpp-2015-0117  0.588
2015 Fortin JS, Santamaria-Bouvier A, Lair S, Dallaire AD, Benoit-Biancamano MO. Anatomic and molecular characterization of the endocrine pancreas of a teleostean fish: Atlantic wolffish (). Zoological Studies. 54: e21. PMID 31966108 DOI: 10.1186/S40555-014-0093-4  0.4
2015 Fortin JS, Benoit-Biancamano MO. Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 22: 194-202. PMID 26300107 DOI: 10.3109/13506129.2015.1070824  0.509
2015 Fortin JS, Benoit-Biancamano MO. In vitro evaluation of hypoglycemic agents to target human islet amyloid polypeptide: a key protein involved in amyloid deposition and beta-cell loss. Canadian Journal of Diabetes. 39: 373-82. PMID 25862064 DOI: 10.1016/J.Jcjd.2015.01.291  0.496
2015 Fortin J, Guérin B, Benoit-Biancamano M. Development of an Amyloid (AIAPP) Radiotracer for the Diagnosis and Management of Type 2 Diabetes Mellitus Canadian Journal of Diabetes. 39: 171. DOI: 10.1016/J.Jcjd.2015.01.287  0.379
2014 Fortin JS, Benoit-Biancamano MO. Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus). Zoo Biology. 33: 446-51. PMID 25273481 DOI: 10.1002/Zoo.21172  0.374
2013 Fortin JS, Benoit-Biancamano M. Wildlife Sequencing: Insights into IAPP Pathogenesis in Type 2 Diabetes Canadian Journal of Diabetes. 37: 59-60. DOI: 10.1016/J.Jcjd.2013.03.008  0.314
2010 Patenaude A, Fortin JS, Deschenes R, Côté MF, Lacroix J, C-Gaudreault R, Petitclerc E. Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation. Canadian Journal of Physiology and Pharmacology. 88: 1102-14. PMID 21076498 DOI: 10.1139/y10-084  0.34
2010 Fortin J, Patenaude A, Deschesnes RG, Côté MF, Petitclerc E, C-Gaudreault R.. ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas. J Pharm Pharm Sci. 13: 175-90. PMID 20816004 DOI: 10.18433/j31g6c  0.333
2010 Fortin J, Patenaude A, Deschesnes RG, Côté MF, Petitclerc E, C-Gaudreault R. ASK1-P38 pathway is important for anoikis induced by microtubule-targeting aryl chloroethylureas. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 13: 175-90. PMID 20816004 DOI: 10.18433/J31G6C  0.425
2010 Qin Y, Fortin JS, Tye D, Gleason-Guzman M, Brooks TA, Hurley LH. Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression. Biochemistry. 49: 4208-19. PMID 20377208 DOI: 10.1021/Bi100330W  0.531
2010 Brown RV, Gaerig VC, Fortin JS, Brooks TA. Abstract 3681: Helping Eve overcome ADAM: Characterization of the G-quadruplex in the ADAM15 core promoter Cancer Research. 70: 3681-3681. DOI: 10.1158/1538-7445.Am10-3681  0.393
2010 Gaerig VC, Fortin JS, Brown RV, Brooks TA. Abstract 1386: A novel approach to develop anti-VEGFR2/KDR therapeutics: characterizing and targeting the G-quadruplex Cancer Research. 70: 1386-1386. DOI: 10.1158/1538-7445.Am10-1386  0.412
2008 Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R. Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents. Bioorganic & Medicinal Chemistry. 16: 7277-90. PMID 18617414 DOI: 10.1016/J.Bmc.2008.06.028  0.437
2008 Fortin JS, Côté MF, Lacroix J, Petitclerc E, C-Gaudreault R. Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression. Bioorganic & Medicinal Chemistry. 16: 7477-88. PMID 18579387 DOI: 10.1016/J.Bmc.2008.06.006  0.429
2008 Fortin JS, Côté MF, Lacroix J, Patenaude A, Petitclerc E, C-Gaudreault R. Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation. Bioorganic & Medicinal Chemistry Letters. 18: 3526-31. PMID 18502639 DOI: 10.1016/J.Bmcl.2008.05.028  0.373
2007 Fortin JS, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C-Gaudreault R. Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site. Bioorganic & Medicinal Chemistry. 15: 4456-69. PMID 17498960 DOI: 10.1016/J.Bmc.2007.04.028  0.366
2007 Deschesnes RG, Patenaude A, Rousseau JL, Fortin JS, Ricard C, Côté MF, Huot J, C-Gaudreault R, Petitclerc E. Microtubule-destabilizing agents induce focal adhesion structure disorganization and anoikis in cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 320: 853-64. PMID 17099073 DOI: 10.1124/Jpet.106.110957  0.398
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