Affiliations: | | Molecular Biology, Cell Biology and Biochemistry | Brown University, Providence, RI |
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High-probability grants
According to our matching algorithm, Philip A. Gruppuso is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2009 — 2013 |
Gruppuso, Philip A. |
T35Activity Code Description: To provide individuals with research training during off-quarters or summer periods to encourage research careers and/or research in areas of national need. |
Alpert Medical School Summer Research Program
The Alpert Medical School Summer Research Program (AMSSRP) in Molecular Pathobiology and Health Services/Outcomes research in cardiopulmonary diseases proposes to support summer research training. The primary objectives are to provide medical students with experience in biomedical research and to encourage them to embark on careers as physician scientists. A secondary objective is to provide students with a single research mentor and focus that will follow them through the entirety of their medical school training. The larger context for the AMSSRP is a unique Scholarly Concentrations (SC) program that encourages students to develop a scholarly interest that they pursue during all four years of medical school. Support is sought for 6 students to spend 10 weeks in the summer following the first year of medical school working in a research laboratory at Brown under the supervision of a faculty trainer. Twenty-six Brown researchers with extensive training experience from a variety of disciplines and departments will offer students the opportunity to join their laboratories for summer research. Seven junior faculty members will also serve as trainers. These individuals will be paired with senior faculty to provide guidance in mentoring students. Faculty will also serve as the student's Concentration mentors. Students will develop a research proposal and preliminary Concentration proposal during the winter of their first medical school year. The AMSSRP Executive Committee will evaluate the proposals and make awards based on scientific merit and the student's potential for and commitment to a research career. In addition to the mentored research experience, students will participate in weekly seminars on core research subjects, including the ethical conduct of research. Faculty trainers will participate in these seminars, both describing their research and discussing their own career development. During the fall after their summer experience, students will present their research at a medical school-wide student research symposium. The AMSSRP will provide our students with research experience that, as a component of the SC program, will serve to promote their development as physician-scientists with a focus on cardiopulmonary diseases.
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2010 — 2012 |
Gruppuso, Philip A. |
P20Activity Code Description: To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. |
Project 1: Human Fetal Liver and the Metabolic Syndrome
PROJECT 1 - Human Fetal Liver and the Metabolic Syndrome. The purpose of this project is to develop and employ a model for studying the effects of arsenic on fetal liver development. The project is predicated on the relationship between altered fetal liver development and risk for metabolic syndrome in the offspring. The role of the liver In metabolic regulation and insulin sensitivity is well established. The association between intrauterine growth retardation, fetal metabolic programming and metabolic syndrome in the offspring is also established, having been shown in recent years to involve epigenetic mechanisms. The goal of this project is to develop a model in which human fetal liver is xenografted to nude rats. We will use this model to test the hypothesis that, like alterations in the nutrient environment, fetal arsenic exposure induces epigenetic changes in fetal liver that predispose to metabolic syndrome in the adult The proposal is based on published evidence that fetal arsenic exposure induces epigenetic changes in fetal liver. The proposal also derives from our extensive characterization of growth-regulating signaling mechanisms in the fetal rat and our identification of novel biomarkers for the fetal hepatocyte phenotype. We have shown that late term fetal hepatocytes, unlike adult rat hepatocytes, show mitogenindependent proliferation and are resistance to the anti-proliferative effects of rapamycin, an inhibitor of the nutrient-sensing mTOR pathway. The aforementioned biomarkers include a number of proteins involved in growth factor signaling, cell cycle control and translation control. We have also observed that rapamycin-induced inhibition of mTOR modulates gene expression in a manner most consistent with epigenetic mechanisms. We have developed the following specific aims: Specific Aim 1 will be to develop a model in which human fetal liver is transplanted into nude rats and the fetal liver phenotype (defined as above) is maintained. In Specific Aim 2, we will demonstrate that manipulation of the host environment in the adult rat xenograft recipients will induce changes in fetal liver. We will examine the effects of host dietary restriction and rapamycin administration to examine the effect on fetal liver growth and gene expression. Specific Aim 3 will be to characterize and contrast the epigenetic consequences of host dietary restriction and rapamycin with the effects of arsenic exposure. The significance of this project lies in its potential to develop a model system to study mechanisms for programming of human fetal liver, something that is not possible with available methodologies.
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