Holly A. Leddy, Ph.D.

2007 Duke University, Durham, NC 
Biomedical, General, Biomechanics
"Holly Leddy"


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Farshid Guilak grad student 2007 Duke
 (Diffusional properties of articular cartilage.)
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Willard VP, Leddy HA, Palmer D, et al. (2021) Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells (Dayton, Ohio)
Lee W, Nims RJ, Savadipour A, et al. (2021) Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118
Collins AT, Hu G, Newman H, et al. (2021) Obesity alters the collagen organization and mechanical properties of murine cartilage. Scientific Reports. 11: 1626
Gilchrist CL, Leddy HA, Kaye L, et al. (2019) TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Proceedings of the National Academy of Sciences of the United States of America
Zelenski NA, Leddy HA, Sanchez-Adams J, et al. (2015) Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1286-94
McNulty AL, Leddy HA, Liedtke W, et al. (2015) TRPV4 as a therapeutic target for joint diseases. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 437-50
Leddy HA, McNulty AL, Guilak F, et al. (2014) Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias. Rare Diseases (Austin, Tex.). 2: e962971
Lee W, Leddy HA, Chen Y, et al. (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22
Sanchez-Adams J, Leddy HA, McNulty AL, et al. (2014) The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Current Rheumatology Reports. 16: 451
Leddy HA, McNulty AL, Lee SH, et al. (2014) Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2525-37
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