Brian O. Diekman, Ph.D.
Affiliations: | 2012 | Biomedical Engineering | Duke University, Durham, NC |
Area:
Biomedical, General, BiomechanicsGoogle:
"Brian Diekman"Parents
Sign in to add mentor| Farshid Guilak | grad student | 2012 | Duke | |
| (Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis.) | ||||
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Publications
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| Copp ME, Flanders MC, Gagliardi R, et al. (2020) The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence. Osteoarthritis and Cartilage |
| Coryell PR, Diekman BO, Loeser RF. (2020) Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nature Reviews. Rheumatology |
| Tessier S, Doolittle AC, Sao K, et al. (2020) Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. Jci Insight |
| D'Costa S, Rich MJ, Diekman BO. (2019) Engineered cartilage from human chondrocytes with homozygous knockout of cell cycle inhibitor p21. Tissue Engineering. Part A |
| Sessions GA, Copp ME, Liu JY, et al. (2019) Controlled induction and targeted elimination of p16-expressing chondrocytes in cartilage explant culture. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900815RR |
| Novais EM, Diekman BO, Shapiro IM, et al. (2019) p16 deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biology : Journal of the International Society For Matrix Biology |
| Liu JY, Souroullas GP, Diekman BO, et al. (2019) Cells exhibiting strong promoter activation in vivo display features of senescence. Proceedings of the National Academy of Sciences of the United States of America |
| Sessions GA, Sinkler MA, Copp ME, et al. (2019) Controlled induction and targeted elimination of P16INK4A-high chondrocytes to investigate senescence-mediated cartilage dysfunction Osteoarthritis and Cartilage. 27 |
| Diekman BO, Sessions GA, Collins JA, et al. (2018) Expression of p16 is a biomarker of chondrocyte aging but does not cause osteoarthritis. Aging Cell. e12771 |
| Diekman B, Rotty J, Ulici V, et al. (2017) Chondrocyte-Specific Loss of the Branched Actin Mediator ARP2/3 Results in Growth Plate Fusion and Proteoglycan Loss in Articular Cartilage Osteoarthritis and Cartilage. 25: S277-S278 |