Samuel C. Nalle, Ph.D.

Affiliations: 
2011 Pathology University of Chicago, Chicago, IL 
Area:
Immunology
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"Samuel Nalle"

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Jerrold R. Turner grad student 2011 Chicago
 (Intestinal damage and tight junction dysfunction are essential for minor mismatch graft-versus-host disease.)
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Publications

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Nalle SC, Zuo L, Ong MLDM, et al. (2019) Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. The Journal of Clinical Investigation
Nalle SC, Turner JR. (2015) Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease. Mucosal Immunology. 8: 720-30
Nalle SC, Kwak HA, Edelblum KL, et al. (2014) Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Science Translational Medicine. 6: 243ra87
Su L, Nalle SC, Shen L, et al. (2013) TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 145: 407-15
Nalle SC, Turner JR. (2012) Endothelial and epithelial barriers in graft-versus-host disease. Advances in Experimental Medicine and Biology. 763: 105-31
Nalle SC, Turner JR. (2009) Menetrier's disease therapy: rebooting mucosal signaling. Science Translational Medicine. 1: 8ps10
Nalle SC, Turner JR. (2009) Epithelium, tear down this wall! Cell Host & Microbe. 5: 1-2
Su L, Shen L, Clayburgh DR, et al. (2009) Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 136: 551-63
Weber CR, Nalle SC, Tretiakova M, et al. (2008) Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 1110-20
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