Christopher O'Conor

Biomedical Engineering University of North Carolina, Chapel Hill, Chapel Hill, NC 
Osteoarthritis, Cell Biology, Molecular Biology, Biotechnology
"Christopher O'Conor"
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Nims RJ, Pferdehirt L, Ho NB, et al. (2021) A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Science Advances. 7
O'Conor CJ, Ramalingam S, Zelenski NA, et al. (2016) Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. Scientific Reports. 6: 29053
Sanchez-Adams J, Leddy HA, McNulty AL, et al. (2014) The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Current Rheumatology Reports. 16: 451
O'Conor CJ, Leddy HA, Benefield HC, et al. (2014) TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proceedings of the National Academy of Sciences of the United States of America. 111: 1316-21
O'Conor CJ, Case N, Guilak F. (2013) Mechanical regulation of chondrogenesis. Stem Cell Research & Therapy. 4: 61
O'Conor CJ, Griffin TM, Liedtke W, et al. (2013) Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Annals of the Rheumatic Diseases. 72: 300-4
O'Conor CJ, Benefield HC, Liedtke W, et al. (2013) Osmotic or chemical activation of the TRPV4 ion channel enhances the development of chondrocyte-based tissue engineered cartilage Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1
Garrigues NW, Little D, O'Conor CJ, et al. (2010) Use of an insulating mask for controlling anisotropy in multilayer electrospun scaffolds for tissue engineering. Journal of Materials Chemistry. 20: 8962-8968
Ng KW, Lima EG, Bian L, et al. (2010) Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model. Tissue Engineering. Part A. 16: 1041-51
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