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Ji Luo, Ph.D. - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
PI3K and cancer metabolism
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhang H, Read A, Cataisson C, Yang HH, Lee WC, Turk BE, Yuspa SH, Luo J. Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in - and -mutant cancer cells. Science Signaling. 17: eadd5073. PMID 38743809 DOI: 10.1126/scisignal.add5073  0.606
2022 Zhao K, Yu C, Luo J, Huang M, Wen Q, Zhao N. 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 acts as a protein kinase to regulate glioblastoma progression by activating the AKT/forkhead box O1 pathway. Acta Biochimica Polonica. PMID 35143148 DOI: 10.18388/abp.2020_5789  0.33
2021 Gu C, Liu J, Liu X, Zhang H, Luo J, Wang H, Locasale JW, Shears SB. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33649228 DOI: 10.1073/pnas.2020187118  0.568
2020 Steinebach C, Ng YLD, Sosič I, Lee CS, Chen S, Lindner S, Vu LP, Bricelj A, Haschemi R, Monschke M, Steinwarz E, Wagner KG, Bendas G, Luo J, Gütschow M, et al. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chemical Science. 11: 3474-3486. PMID 33133483 DOI: 10.1039/d0sc00167h  0.336
2019 Lee CS, Lee LC, Yuan TL, Chakka S, Fellmann C, Lowe SW, Caplen NJ, McCormick F, Luo J. MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 30709910 DOI: 10.1073/Pnas.1817494116  0.677
2018 Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, ... ... Luo J, et al. Differential Effector Engagement by Oncogenic KRAS. Cell Reports. 22: 1889-1902. PMID 29444439 DOI: 10.1016/J.Celrep.2018.01.051  0.678
2017 Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes & Development. 31: 1933-1938. PMID 29089421 DOI: 10.1101/Gad.304857.117  0.348
2017 Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J. CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level. Nucleic Acids Research. PMID 29036671 DOI: 10.1093/Nar/Gkx843  0.337
2017 Sissung TM, Ley AM, Strope JD, McCrea EM, Beedie SL, Peer CJ, Shukla S, van Velkinburgh JC, Reece K, Troutman S, Campbell T, Fernandez E, Huang P, Smith J, Thakkar N, ... ... Luo J, et al. Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx. Molecular Cancer Research : McR. PMID 28389619 DOI: 10.1158/1541-7786.Mcr-16-0477  0.302
2016 Taniguchi C, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley L, Kahn C. Divergent Regulation of Hepatic Glucose and Lipid Metabolism by Phosphoinositide 3-Kinase via Akt and PKCλ/ζ Cell Metabolism. 23: 386. DOI: 10.1016/J.Cmet.2016.01.016  0.486
2015 Jossé R, Zhang YW, Giroux V, Ghosh AK, Luo J, Pommier Y. Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation. Marine Drugs. 13: 3625-39. PMID 26058013 DOI: 10.3390/Md13063625  0.424
2015 Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu D, Smith JL, Yuen G, Yue J, Ann DK, Simpson RM, Creighton CJ, Figg WD, Gucek M, ... Luo J, et al. Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9. Proceedings of the National Academy of Sciences of the United States of America. 112: E1724-33. PMID 25805818 DOI: 10.1073/Pnas.1415569112  0.396
2014 Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discovery. 4: 1182-97. PMID 25100204 DOI: 10.1158/2159-8290.Cd-13-0900  0.64
2014 Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov A, Luo J. A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein. Plos One. 9: e103836. PMID 25093678 DOI: 10.1371/Journal.Pone.0103836  0.314
2014 Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee C, Carver J, Creighton C, Ann DK, Figg WD, Gucek M, Luo J. Abstract B29: A critical role of the SUMO pathway in KRAS-driven oncogenesis Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B29  0.395
2013 Davoli T, Solimini NL, Pavlova NN, Xu Q, Mengwasser K, Sack LM, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Li MZ, Elledge SJ. Abstract IA28: Haploinsufficiency in cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia28  0.359
2013 Yuan TL, Lee C, Fellmann C, Ritchie C, Lee C, Merrifield C, Schluep T, Lowe SW, Luo J, McCormick F. Abstract LB-94: Nanoparticle-based RNAi therapy for the delivery of personalized siRNA payloads to KRAS-driven tumors. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-94  0.66
2013 Park K, Giuseppe G, Wang Y, Pham T, Moon Y, Luo J, Lee LC, Mitsudomi T, Okamoto I, Yatabe Y, Mok T, Raffeld M, Xi L, Salomon DS, Bianco C. Abstract 4468: Cripto-1 elicits innate resistance to EGFR inhibitors in non-small cell lung cancer harboring EGFR-sensitizing mutations. Cancer Research. 73: 4468-4468. DOI: 10.1158/1538-7445.Am2013-4468  0.312
2013 Zhang Y, Josse R, Ghosh A, Luo J, Pommier Y. Abstract 2117: Lasonolide A-induced premature chromosome condensation is mediated by the proto-oncogene c-Raf (Raf1). Cancer Research. 73: 2117-2117. DOI: 10.1158/1538-7445.Am2013-2117  0.441
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Luo J, et al. 112 Genfome-wide shRNA Screening Defines the SUMO-activating Enzyme (SAE1/2) as a Novel Therapeutic Target for Tumors Driven by c-Myc Oncogenesis. Neurosurgery. 71: E547. PMID 28175742 DOI: 10.1227/01.Neu.0000417701.96799.49  0.304
2012 Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (New York, N.Y.). 337: 104-9. PMID 22628553 DOI: 10.1126/Science.1219580  0.304
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Luo J, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/Science.1212728  0.364
2012 Solimini NL, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ, Pavlova NN, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN. Abstract IA8: Genetic approaches to cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Csb12-Ia8  0.323
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Luo J, et al. Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Cancer Research. 72: 3091-3091. DOI: 10.1158/1538-7445.Am2012-3091  0.375
2010 Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, et al. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metabolism. 12: 619-32. PMID 21109194 DOI: 10.1016/J.Cmet.2010.11.005  0.523
2010 Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.Can-09-3399  0.533
2009 Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 150: 4874-82. PMID 19819947 DOI: 10.1210/En.2009-0454  0.484
2009 Acosta-Martínez M, Luo J, Elias C, Wolfe A, Levine JE. Male-biased effects of gonadotropin-releasing hormone neuron-specific deletion of the phosphoinositide 3-kinase regulatory subunit p85alpha on the reproductive axis. Endocrinology. 150: 4203-12. PMID 19541766 DOI: 10.1210/En.2008-1753  0.317
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/J.Cell.2009.05.006  0.354
2009 Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 136: 823-37. PMID 19269363 DOI: 10.1016/J.Cell.2009.02.024  0.331
2009 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) Proceedings of the National Academy of Sciences of the United States of America. 106: 10871. DOI: 10.1073/Pnas.0905401106  0.476
2009 Nakamura M, Masuda H, Iwasawa M, Nagase Y, Nakamura T, Kato S, Ueki K, Luo J, Cantley L, Nakamura K, Tanaka S. Class IA phosphatidylinositol 3-kinases are indispensable for osteoclast function by regulating cytoskeletal organization and cell death Bone. 44: S49-S50. DOI: 10.1016/J.Bone.2009.01.127  0.5
2008 Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9739-44. PMID 18621722 DOI: 10.1073/Pnas.0804123105  0.685
2008 Luo J, Elledge SJ. Cancer: Deconstructing oncogenesis Nature. 453: 995-996. PMID 18563141 DOI: 10.1038/453995A  0.32
2008 Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. The Journal of Clinical Investigation. 118: 1796-805. PMID 18382766 DOI: 10.1172/Jci32964  0.47
2008 Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, et al. Cancer proliferation gene discovery through functional genomics Science. 319: 620-624. PMID 18239126 DOI: 10.1126/Science.1149200  0.355
2007 Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 8077-82. PMID 17483449 DOI: 10.1073/Pnas.0702663104  0.722
2007 Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 129: 289-301. PMID 17412408 DOI: 10.1016/J.Cell.2007.03.009  0.308
2007 Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Molecular and Cellular Biology. 27: 2830-40. PMID 17283057 DOI: 10.1128/Mcb.00079-07  0.511
2007 Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 109: 2894-902. PMID 17164340 DOI: 10.1182/Blood-2006-07-038620  0.5
2006 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16882-7. PMID 17071741 DOI: 10.1073/Pnas.0607984103  0.49
2006 Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proceedings of the National Academy of Sciences of the United States of America. 103: 12093-7. PMID 16880400 DOI: 10.1073/Pnas.0604628103  0.521
2006 Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews. Genetics. 7: 606-19. PMID 16847462 DOI: 10.1038/Nrg1879  0.52
2006 Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metabolism. 3: 355-66. PMID 16679293 DOI: 10.1016/J.Cmet.2006.04.003  0.48
2006 Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metabolism. 3: 343-53. PMID 16679292 DOI: 10.1016/J.Cmet.2006.04.005  0.525
2006 Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. Journal of Medicinal Chemistry. 49: 740-7. PMID 16420059 DOI: 10.1021/Jm050699P  0.47
2005 Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Research. 65: 10992-1000. PMID 16322248 DOI: 10.1158/0008-5472.Can-05-2612  0.5
2005 Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Molecular and Cellular Biology. 25: 9491-502. PMID 16227599 DOI: 10.1128/Mcb.25.21.9491-9502.2005  0.479
2005 Luo J, Cantley LC. The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. Cell Cycle (Georgetown, Tex.). 4: 1309-12. PMID 16131837 DOI: 10.4161/Cc.4.10.2062  0.55
2005 Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. The Journal of Cell Biology. 170: 455-64. PMID 16043515 DOI: 10.1083/Jcb.200503088  0.702
2005 Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/Pnas.0504378102  0.55
2005 Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjugate Chemistry. 16: 669-75. PMID 15898736 DOI: 10.1021/Bc049714F  0.706
2003 Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 4: 257-62. PMID 14585353 DOI: 10.1016/S1535-6108(03)00248-4  0.453
2000 Luo J, Cantley LC. Phosphoinositide biology – messages from lipids Nature Cell Biology. 2. PMID 11025682 DOI: 10.1038/35036447  0.392
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