Year |
Citation |
Score |
2023 |
Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M. CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling. Nature Communications. 14: 3560. PMID 37322019 DOI: 10.1038/s41467-023-39281-z |
0.337 |
|
2022 |
Lavoie H, Therrien M. Structural keys unlock RAS-MAPK cellular signalling pathway. Nature. PMID 35970881 DOI: 10.1038/d41586-022-02189-7 |
0.569 |
|
2020 |
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, ... ... Therrien M, et al. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nature Chemical Biology. PMID 32778845 DOI: 10.1038/S41589-020-0609-7 |
0.454 |
|
2020 |
Lavoie H, Gagnon J, Therrien M. ERK signalling: a master regulator of cell behaviour, life and fate. Nature Reviews. Molecular Cell Biology. PMID 32576977 DOI: 10.1038/s41580-020-0255-7 |
0.433 |
|
2018 |
Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, ... ... Therrien M, et al. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. American Journal of Medical Genetics. Part A. e40632. PMID 30302932 DOI: 10.1002/Ajmg.A.40632 |
0.422 |
|
2018 |
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. MEK drives BRAF activation through allosteric control of KSR proteins. Nature. PMID 29433126 DOI: 10.1038/Nature25478 |
0.354 |
|
2017 |
Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M. RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition. Nature Communications. 8: 1211. PMID 29084939 DOI: 10.1038/s41467-017-01274-0 |
0.438 |
|
2017 |
Kubiniok P, Lavoie H, Therrien M, Thibault P. Time-resolved phosphoproteome analysis of paradoxical RAF activation reveals novel targets of ERK. Molecular & Cellular Proteomics : McP. PMID 28188228 DOI: 10.1074/Mcp.M116.065128 |
0.461 |
|
2017 |
Ashton-Beaucage D, Therrien M. How Genetics Has Helped Piece Together the MAPK Signaling Pathway. Methods in Molecular Biology (Clifton, N.J.). 1487: 1-21. PMID 27924555 DOI: 10.1007/978-1-4939-6424-6_1 |
0.464 |
|
2016 |
Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, ... ... Therrien M, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nature Chemical Biology. PMID 27820802 DOI: 10.1038/Nchembio.2231 |
0.485 |
|
2016 |
Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. Plos Biology. 14: e1002539. PMID 27552662 DOI: 10.1371/journal.pbio.1002539 |
0.54 |
|
2015 |
Lavoie H, Therrien M. Regulation of RAF protein kinases in ERK signalling. Nature Reviews. Molecular Cell Biology. 16: 281-98. PMID 25907612 DOI: 10.1038/nrm3979 |
0.425 |
|
2014 |
Baril C, Lefrançois M, Sahmi M, Knævelsrud H, Therrien M. Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1. Genetics. 197: 1237-50. PMID 24899161 DOI: 10.1534/genetics.114.166272 |
0.606 |
|
2014 |
Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M. A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. Plos Biology. 12: e1001809. PMID 24643257 DOI: 10.1371/Journal.Pbio.1001809 |
0.589 |
|
2011 |
Udell CM, Rajakulendran T, Sicheri F, Therrien M. Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences : Cmls. 68: 553-65. PMID 20820846 DOI: 10.1007/S00018-010-0520-6 |
0.338 |
|
2010 |
Ashton-Beaucage D, Therrien M. [The greater RTK/RAS/ERK signalling pathway: how genetics has helped piece together a signalling network]. MéDecine Sciences : M/S. 26: 1067-73. PMID 21187046 DOI: 10.1051/medsci/201026121067 |
0.487 |
|
2010 |
Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M. The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila. Cell. 143: 251-62. PMID 20946983 DOI: 10.1016/J.Cell.2010.09.014 |
0.482 |
|
2009 |
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 461: 542-5. PMID 19727074 DOI: 10.1038/Nature08314 |
0.471 |
|
2009 |
Baril C, Sahmi M, Ashton-Beaucage D, Stronach B, Therrien M. The PP2C Alphabet is a negative regulator of stress-activated protein kinase signaling in Drosophila. Genetics. 181: 567-79. PMID 19064708 DOI: 10.1534/Genetics.108.096461 |
0.426 |
|
2008 |
Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 2836-41. PMID 18287031 DOI: 10.1073/Pnas.0709705105 |
0.306 |
|
2007 |
Clapéron A, Therrien M. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene. 26: 3143-58. PMID 17496912 DOI: 10.1038/sj.onc.1210408 |
0.587 |
|
2006 |
Douziech M, Sahmi M, Laberge G, Therrien M. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes & Development. 20: 807-19. PMID 16600912 DOI: 10.1101/gad.1390406 |
0.473 |
|
2006 |
Baril C, Therrien M. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Developmental Biology. 294: 232-45. PMID 16600208 DOI: 10.1016/j.ydbio.2006.02.046 |
0.58 |
|
2005 |
Laberge G, Douziech M, Therrien M. Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism. The Embo Journal. 24: 487-98. PMID 15660123 DOI: 10.1038/sj.emboj.7600558 |
0.419 |
|
2003 |
Douziech M, Roy F, Laberge G, Lefrançois M, Armengod AV, Therrien M. Bimodal regulation of RAF by CNK in Drosophila. The Embo Journal. 22: 5068-78. PMID 14517245 DOI: 10.1093/emboj/cdg506 |
0.478 |
|
2002 |
Roy F, Therrien M. MAP kinase module: the Ksr connection. Current Biology : Cb. 12: R325-7. PMID 12007434 DOI: 10.1016/S0960-9822(02)00831-X |
0.361 |
|
2002 |
Roy F, Laberge G, Douziech M, Ferland-McCollough D, Therrien M. KSR is a scaffold required for activation of the ERK/MAPK module. Genes & Development. 16: 427-38. PMID 11850406 DOI: 10.1101/gad.962902 |
0.54 |
|
2000 |
Therrien M, Morrison DK, Wong AM, Rubin GM. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics. 156: 1231-42. PMID 11063697 |
0.695 |
|
1999 |
Therrien M, Wong AM, Kwan E, Rubin GM. Functional analysis of CNK in RAS signaling. Proceedings of the National Academy of Sciences of the United States of America. 96: 13259-63. PMID 10557308 DOI: 10.1073/Pnas.96.23.13259 |
0.725 |
|
1999 |
Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK. Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Molecular and Cellular Biology. 19: 229-40. PMID 9858547 DOI: 10.1128/Mcb.19.1.229 |
0.729 |
|
1998 |
Therrien M, Wong AM, Rubin GM. CNK, a RAF-binding multidomain protein required for RAS signaling. Cell. 95: 343-53. PMID 9814705 DOI: 10.1016/S0092-8674(00)81766-3 |
0.761 |
|
1997 |
Rubin GM, Chang HC, Karim F, Laverty T, Michaud NR, Morrison DK, Rebay I, Tang A, Therrien M, Wassarman DA. Signal transduction downstream from Ras in Drosophila. Cold Spring Harbor Symposia On Quantitative Biology. 62: 347-52. PMID 9598368 DOI: 10.1101/Sqb.1997.062.01.041 |
0.763 |
|
1997 |
Michaud NR, Therrien M, Cacace A, Edsall LC, Spiegel S, Rubin GM, Morrison DK. KSR stimulates Raf-1 activity in a kinase-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 94: 12792-6. PMID 9371754 DOI: 10.1073/pnas.94.24.12792 |
0.729 |
|
1997 |
Wassarman DA, Therrien M. Ras1-Mediated Photoreceptor Development in Drosophila Advances in Developmental Biology (1992). 5: 1-41. DOI: 10.1016/S1566-3116(08)60034-1 |
0.62 |
|
1996 |
Therrien M, Michaud NR, Rubin GM, Morrison DK. KSR modulates signal propagation within the MAPK cascade. Genes & Development. 10: 2684-95. PMID 8946910 DOI: 10.1101/Gad.10.21.2684 |
0.743 |
|
1996 |
Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T, Rubin GM. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics. 143: 315-29. PMID 8722784 |
0.795 |
|
1996 |
Wassarman DA, Solomon NM, Chang HC, Karim FD, Therrien M, Rubin GM. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila. Genes & Development. 10: 272-8. PMID 8595878 DOI: 10.1101/Gad.10.3.272 |
0.774 |
|
1995 |
Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM. KSR, a novel protein kinase required for RAS signal transduction. Cell. 83: 879-88. PMID 8521512 DOI: 10.1016/0092-8674(95)90204-X |
0.802 |
|
1995 |
Chang HC, Solomon NM, Wassarman DA, Karim FD, Therrien M, Rubin GM, Wolff T. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell. 80: 463-72. PMID 7888014 DOI: 10.1016/0092-8674(95)90497-2 |
0.714 |
|
1995 |
Wassarman DA, Therrien M, Rubin GM. The Ras signaling pathway in Drosophila. Current Opinion in Genetics & Development. 5: 44-50. PMID 7749324 DOI: 10.1016/S0959-437X(95)90052-7 |
0.816 |
|
1994 |
Chang HC, Karim FD, O'Neill EM, Rebay I, Solomon NM, Therrien M, Wassarman DA, Wolff T, Rubin GM. Ras signal transduction pathway in Drosophila eye development. Cold Spring Harbor Symposia On Quantitative Biology. 59: 147-53. PMID 7587064 DOI: 10.1101/Sqb.1994.059.01.018 |
0.744 |
|
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