Leonidas G. Alexopoulos, Ph.D. - Publications

Affiliations: 
2004 Duke University, Durham, NC 
Area:
Biomedical, General, Biomechanics

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Skorda A, Sklirou AD, Sakellaropoulos T, Gianniou DD, Kastritis E, Terpos E, Tsitsilonis OE, Florea BI, Overkleeft HS, Dimopoulos MA, Alexopoulos LG, Trougakos IP. Non-lethal proteasome inhibition activates pro-tumorigenic pathways in multiple myeloma cells. Journal of Cellular and Molecular Medicine. PMID 31568628 DOI: 10.1111/jcmm.14653  0.4
2019 Kotelnikova E, Kiani NA, Messinis D, Pertsovskaya I, Pliaka V, Bernardo-Faura M, Rinas M, Vila G, Zubizarreta I, Pulido-Valdeolivas I, Sakellaropoulos T, Faigle W, Silberberg G, Masso M, Stridh P, ... ... Alexopoulos LG, et al. MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31004050 DOI: 10.1073/pnas.1818347116  0.4
2019 Melas IN, Sakellaropoulos T, Hur J, Messinis D, Guo EY, Alexopoulos LG, Bai JPF. A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine. Methods in Molecular Biology (Clifton, N.J.). 1939: 181-198. PMID 30848462 DOI: 10.1007/978-1-4939-9089-4_10  0.4
2018 Rožanc J, Sakellaropoulos T, Antoranz A, Guttà C, Podder B, Vetma V, Rufo N, Agostinis P, Pliaka V, Sauter T, Kulms D, Rehm M, Alexopoulos LG. Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death and Differentiation. PMID 30323272 DOI: 10.1038/s41418-018-0210-8  0.4
2018 Cheimonidi C, Samara P, Polychronopoulos P, Tsakiri EN, Nikou T, Myrianthopoulos V, Sakellaropoulos T, Zoumpourlis V, Mikros E, Papassideri I, Argyropoulou A, Halabalaki M, Alexopoulos LG, Skaltsounis AL, Tsitsilonis OE, et al. Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights. Redox Biology. 16: 169-178. PMID 29505920 DOI: 10.1016/j.redox.2018.02.015  0.4
2018 Messinis DE, Melas IN, Hur J, Varshney N, Alexopoulos LG, Bai JPF. Translational systems pharmacology-based predictive assessment of drug-induced cardiomyopathy. Cpt: Pharmacometrics & Systems Pharmacology. PMID 29341478 DOI: 10.1002/psp4.12272  0.4
2017 Fotis C, Antoranz A, Hatziavramidis D, Sakellaropoulos T, Alexopoulos LG. Pathway-based technologies for early drug discovery. Drug Discovery Today. PMID 29294361 DOI: 10.1016/j.drudis.2017.12.001  0.4
2017 Antoranz A, Sakellaropoulos T, Saez-Rodriguez J, Alexopoulos LG. Mechanism-based biomarker discovery. Drug Discovery Today. PMID 28458042 DOI: 10.1016/j.drudis.2017.04.013  0.4
2017 Bai JP, Sakellaropoulos T, Alexopoulos LG. A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection. Toxins. 9. PMID 28287432 DOI: 10.3390/toxins9030099  0.4
2016 Sakellaropoulos T, Herod TJ, Alexopoulos LG, Bai JP. Computed biological relations among 5 select treatment-related organ/tissue toxicities. Chemical Research in Toxicology. PMID 27063352 DOI: 10.1021/acs.chemrestox.6b00060  0.4
2015 Stavrakas V, Melas IN, Sakellaropoulos T, Alexopoulos LG. Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory. Plos One. 10: e0128411. PMID 26020784 DOI: 10.1371/journal.pone.0128411  1
2015 Melas IN, Sakellaropoulos T, Iorio F, Alexopoulos LG, Loh WY, Lauffenburger DA, Saez-Rodriguez J, Bai JP. Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25932872 DOI: 10.1039/c4ib00294f  0.4
2015 Bilal E, Sakellaropoulos T, Melas IN, Messinis DE, Belcastro V, Rhrissorrakrai K, Meyer P, Norel R, Iskandar A, Blaese E, Rice JJ, Peitsch MC, Hoeng J, Stolovitzky G, Alexopoulos LG, et al. A crowd-sourcing approach for the construction of species-specific cell signaling networks. Bioinformatics (Oxford, England). 31: 484-91. PMID 25294919 DOI: 10.1093/bioinformatics/btu659  0.4
2015 Kotelnikova E, Bernardo-Faura M, Silberberg G, Kiani NA, Messinis D, Melas IN, Artigas L, Schwartz E, Mazo I, Masso M, Alexopoulos LG, Mas JM, Olsson T, Tegner J, Martin R, et al. Signaling networks in MS: a systems-based approach to developing new pharmacological therapies. Multiple Sclerosis (Houndmills, Basingstoke, England). 21: 138-46. PMID 25112814 DOI: 10.1177/1352458514543339  0.4
2015 Kanakaris GP, Fatsis-Kavalopoulos N, Alexopoulos LG. Laser activated single-use micropumps Sensors and Actuators, B: Chemical. 220: 549-556. DOI: 10.1016/j.snb.2015.04.101  1
2015 Michailidou M, Melas IN, Messinis DE, Klamt S, Alexopoulos LG, Kolisis FN, Loutrari H. Network-based analysis of nutraceuticals in human hepatocellular carcinomas reveals mechanisms of chemopreventive action Cpt: Pharmacometrics and Systems Pharmacology. 4: 351-361. DOI: 10.1002/psp4.40  0.4
2014 Poussin C, Mathis C, Alexopoulos LG, Messinis DE, Dulize RH, Belcastro V, Melas IN, Sakellaropoulos T, Rhrissorrakrai K, Bilal E, Meyer P, Talikka M, Boué S, Norel R, Rice JJ, et al. The species translation challenge-a systems biology perspective on human and rat bronchial epithelial cells. Scientific Data. 1: 140009. PMID 25977767 DOI: 10.1038/sdata.2014.9  0.4
2014 Melas IN, Chairakaki AD, Chatzopoulou EI, Messinis DE, Katopodi T, Pliaka V, Samara S, Mitsos A, Dailiana Z, Kollia P, Alexopoulos LG. Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data Osteoarthritis and Cartilage. 22: 509-518. PMID 24457104 DOI: 10.1016/j.joca.2014.01.001  1
2014 Morris MK, Chi A, Melas IN, Alexopoulos LG. Phosphoproteomics in drug discovery. Drug Discovery Today. 19: 425-32. PMID 24141136 DOI: 10.1016/j.drudis.2013.10.010  0.4
2013 Melas IN, Lauffenburger DA, Alexopoulos LG. Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data. Proceedings / Annual Ieee International Symposium On Bioinformatics and Bioengineering (Bibe). Ieee International Symposium On Bioinformatics and Bioengineering. 2013. PMID 25729777 DOI: 10.1109/BIBE.2013.6701683  0.4
2013 Melas IN, Samaga R, Alexopoulos LG, Klamt S. Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs. Plos Computational Biology. 9: e1003204. PMID 24039561 DOI: 10.1371/journal.pcbi.1003204  0.4
2013 Melas IN, Kretsos K, Alexopoulos LG. Leveraging systems biology approaches in clinical pharmacology. Biopharmaceutics & Drug Disposition. 34: 477-88. PMID 23983165 DOI: 10.1002/bdd.1859  1
2012 Mitsos A, Melas IN, Morris MK, Saez-Rodriguez J, Lauffenburger DA, Alexopoulos LG. Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways. Plos One. 7: e50085. PMID 23226239 DOI: 10.1371/journal.pone.0050085  0.4
2012 Melas IN, Mitsos A, Messinis DE, Weiss TS, Rodriguez JS, Alexopoulos LG. Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data. Molecular Biosystems. 8: 1571-84. PMID 22446821 DOI: 10.1039/c2mb05482e  1
2011 Melas IN, Chairakaki AD, Mitsos A, Dailiana Z, Provatidis CG, Alexopoulos LG. Modeling signaling pathways in articular cartilage. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 3712-5. PMID 22255146 DOI: 10.1109/IEMBS.2011.6090630  1
2011 Melas IN, Mitsos A, Messinis DE, Weiss TS, Alexopoulos LG. Combined logical and data-driven models for linking signalling pathways to cellular response. Bmc Systems Biology. 5: 107. PMID 21729292 DOI: 10.1186/1752-0509-5-107  1
2011 Saez-Rodriguez J, Alexopoulos LG, Stolovitzky G. Setting the standards for signal transduction research. Science Signaling. 4: pe10. PMID 21325202 DOI: 10.1126/scisignal.2001844  1
2010 Alexopoulos LG, Melas IN, Chairakaki AD, Saez-Rodriguez J, Mitsos A. Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2010: 6717-20. PMID 21096084 DOI: 10.1109/IEMBS.2010.5626246  1
2010 Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Molecular & Cellular Proteomics : McP. 9: 1849-65. PMID 20460255 DOI: 10.1074/mcp.M110.000406  1
2010 Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/b926287c  1
2010 Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. Plos One. 5: e9202. PMID 20186320 DOI: 10.1371/journal.pone.0009202  1
2009 Mitsos A, Melas IN, Siminelakis P, Chairakaki AD, Saez-Rodriguez J, Alexopoulos LG. Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data. Plos Computational Biology. 5: e1000591. PMID 19997482 DOI: 10.1371/journal.pcbi.1000591  1
2009 Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology. 5: 331. PMID 19953085 DOI: 10.1038/msb.2009.87  1
2009 Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. Plos Computational Biology. 5: e1000438. PMID 19662154 DOI: 10.1371/journal.pcbi.1000438  1
2009 Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/j.taap.2009.04.002  1
2009 Alexopoulos LG, Youn I, Bonaldo P, Guilak F. Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis and Rheumatism. 60: 771-9. PMID 19248115 DOI: 10.1002/art.24293  1
2008 Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics (Oxford, England). 24: 840-7. PMID 18218655 DOI: 10.1093/bioinformatics/btn018  1
2008 Alexopoulos LG, Lauffenburger DA, Sorger PK. Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli 8th Ieee International Conference On Bioinformatics and Bioengineering, Bibe 2008. DOI: 10.1109/BIBE.2008.4696732  1
2008 Alexopoulos LG, Saez-Rodriguez J, Espelin CW. High-Throughput Protein-Based Technologies and Computational Models for Drug Development, Efficacy, and Toxicity Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools. 29-52. DOI: 10.1002/9780470431818.ch2  1
2006 Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Annals of the New York Academy of Sciences. 1068: 498-512. PMID 16831947 DOI: 10.1196/annals.1346.011  1
2006 Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. IL-1beta decreases the elastic modulus of human tenocytes. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 189-95. PMID 16627678 DOI: 10.1152/japplphysiol.01128.2005  1
2006 Trickey WR, Baaijens FP, Laursen TA, Alexopoulos LG, Guilak F. Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics. 39: 78-87. PMID 16271590 DOI: 10.1016/j.jbiomech.2004.11.006  1
2006 Trickey WR, Baaijens FPT, Laursen TA, Alexopoulos LG, Guilak F. Response to Dr. Schachar Journal of Biomechanics. 39: 2344-2345. DOI: 10.1016/j.jbiomech.2006.06.002  1
2005 Alexopoulos LG, Setton LA, Guilak F. The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomaterialia. 1: 317-25. PMID 16701810 DOI: 10.1016/j.actbio.2005.02.001  1
2005 Guilak F, Alexopoulos LG, Haider MA, Ting-Beall HP, Setton LA. Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization. Annals of Biomedical Engineering. 33: 1312-8. PMID 16240080 DOI: 10.1007/s10439-005-4479-7  1
2005 Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Journal of Biomechanics. 38: 509-17. PMID 15652549 DOI: 10.1016/j.jbiomech.2004.04.012  1
2003 Alexopoulos LG, Haider MA, Vail TP, Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. Journal of Biomechanical Engineering. 125: 323-33. PMID 12929236 DOI: 10.1115/1.1579047  1
2002 Alexopoulos LG, Erickson GR, Guilak F. A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes. Journal of Microscopy. 205: 125-35. PMID 11879427 DOI: 10.1046/j.0022-2720.2001.00976.x  1
2001 Erickson GR, Alexopoulos LG, Guilak F. Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. Journal of Biomechanics. 34: 1527-35. PMID 11716854 DOI: 10.1016/S0021-9290(01)00156-7  1
2001 Alexopoulos LG, Haider MA, Guilak F. An axisymmetric elastic layered half-space model for micropipette aspiration of the chondrocyte pericellular matrix American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 51: 313-314.  1
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