Le Shen, Ph.D. - Publications

Affiliations: 
2005 University of Chicago, Chicago, IL 
Area:
Cell Biology, Pathology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tan X, Shen L, Wang L, Labaciren, Zhang Y, Zhang X, Huang Y. Incidence and risk factors for epidural morphine induced pruritus in parturients receiving cesarean section: A prospective multicenter observational study. Medicine. 98: e17366. PMID 31577735 DOI: 10.1097/MD.0000000000017366  0.4
2019 Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase 3 Expression. Gastroenterology. PMID 31401143 DOI: 10.1053/j.gastro.2019.07.058  0.96
2019 Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 8. PMID 30896405 DOI: 10.7554/eLife.41814  0.68
2019 Shen L, Zhang X, Dawawuzhu, Labaciren, Zhang Y, Xu Z, Huang Y. Pain Clinic in Tibet, China: A Single-Center Retrospective Study. Pain Research & Management. 2019: 9161906. PMID 30766644 DOI: 10.1155/2019/9161906  0.4
2018 Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen L. The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800343R. PMID 30252535 DOI: 10.1096/fj.201800343R  0.68
2018 Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. The Journal of Biological Chemistry. PMID 30242130 DOI: 10.1074/jbc.RA118.003908  0.96
2018 Samanta P, Wang Y, Fuladi S, Zou J, Li Y, Shen L, Weber C, Khalili-Araghi F. Molecular determination of claudin-15 organization and channel selectivity. The Journal of General Physiology. PMID 29915162 DOI: 10.1085/jgp.201711868  0.68
2018 Wu L, Shen L, Zhang Y, Zhang X, Huang Y. Association between the use of a stylet in endotracheal intubation and postoperative arytenoid dislocation: a case-control study. Bmc Anesthesiology. 18: 59. PMID 29855263 DOI: 10.1186/s12871-018-0521-9  0.4
2017 Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host & Microbe. 21: 671-681.e4. PMID 28618266 DOI: 10.1016/j.chom.2017.05.009  0.96
2015 Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochimica Et Biophysica Acta. PMID 26721332 DOI: 10.1016/j.bbagen.2015.12.013  0.96
2015 Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. Elife. 4. PMID 26568313 DOI: 10.7554/eLife.09906  0.96
2015 Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. Journal of Virology. 89: 4311-8. PMID 25653430 DOI: 10.1128/JVI.03468-14  0.32
2014 Turner JR, Buschmann MM, Romero-Calvo I, Sailer A, Shen L. The role of molecular remodeling in differential regulation of tight junction permeability. Seminars in Cell & Developmental Biology. 36: 204-12. PMID 25263012 DOI: 10.1016/j.semcdb.2014.09.022  0.96
2014 Glotfelty LG, Zahs A, Iancu C, Shen L, Hecht GA. Microtubules are required for efficient epithelial tight junction homeostasis and restoration. American Journal of Physiology. Cell Physiology. 307: C245-54. PMID 24920678 DOI: 10.1152/ajpcell.00336.2013  0.96
2014 Ma K, Malhotra P, Soni V, Hedroug O, Annaba F, Dudeja A, Shen L, Turner JR, Khramtsova EA, Saksena S, Dudeja PK, Gill RK, Alrefai WA. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. Plos One. 9: e84221. PMID 24465397 DOI: 10.1371/journal.pone.0084221  0.96
2013 Wu D, Zhang L, Li L, Shen L, Xing Y. Prior image guided undersampled dual energy reconstruction with piecewise polynomial function constraint. Computational and Mathematical Methods in Medicine. 2013: 437917. PMID 24282443 DOI: 10.1155/2013/437917  0.32
2013 Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Molecular Biology of the Cell. 24: 3056-68. PMID 23924897 DOI: 10.1091/mbc.E12-09-0688  0.96
2013 Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 145: 407-15. PMID 23619146 DOI: 10.1053/j.gastro.2013.04.011  0.96
2013 Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. American Journal of Physiology. Gastrointestinal and Liver Physiology. 304: G142-56. PMID 23139219 DOI: 10.1152/ajpgi.00483.2011  0.96
2012 Shen L. Tight junctions on the move: molecular mechanisms for epithelial barrier regulation. Annals of the New York Academy of Sciences. 1258: 9-18. PMID 22731710 DOI: 10.1111/j.1749-6632.2012.06613.x  0.96
2012 Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of γδ intraepithelial lymphocytes requires occludin. Proceedings of the National Academy of Sciences of the United States of America. 109: 7097-102. PMID 22511722 DOI: 10.1073/pnas.1112519109  0.96
2011 Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. The Journal of Cell Biology. 193: 565-82. PMID 21536752 DOI: 10.1083/jcb.201010065  0.96
2011 Guan Y, Watson AJ, Marchiando AM, Bradford E, Shen L, Turner JR, Montrose MH. Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells. American Journal of Physiology. Cell Physiology. 300: C1404-14. PMID 21346149 DOI: 10.1152/ajpcell.00270.2010  0.96
2011 Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. 140: 1208-1218.e1-2. PMID 21237166 DOI: 10.1053/j.gastro.2011.01.004  0.96
2011 Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annual Review of Physiology. 73: 283-309. PMID 20936941 DOI: 10.1146/annurev-physiol-012110-142150  0.96
2010 Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proceedings of the National Academy of Sciences of the United States of America. 107: 8237-41. PMID 20404178 DOI: 10.1073/pnas.0908869107  0.96
2010 Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. The Journal of Cell Biology. 189: 111-26. PMID 20351069 DOI: 10.1083/jcb.200902153  0.96
2010 Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. The Journal of Biological Chemistry. 285: 12037-46. PMID 20177070 DOI: 10.1074/jbc.M109.064808  0.96
2010 Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Molecular Biology of the Cell. 21: 1200-13. PMID 20164257 DOI: 10.1091/mbc.E09-08-0734  0.96
2010 Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. American Journal of Physiology. Cell Physiology. 298: C85-97. PMID 19864322 DOI: 10.1152/ajpcell.00118.2009  0.96
2009 Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. Digestive Diseases (Basel, Switzerland). 27: 443-9. PMID 19897958 DOI: 10.1159/000233282  0.96
2009 Shen L. Functional morphology of the gastrointestinal tract. Current Topics in Microbiology and Immunology. 337: 1-35. PMID 19812978 DOI: 10.1007/978-3-642-01846-6_1  0.96
2009 Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. Annals of the New York Academy of Sciences. 1165: 314-22. PMID 19538322 DOI: 10.1111/j.1749-6632.2009.04050.x  0.96
2009 Mukherjee A, Morosky SA, Shen L, Weber CR, Turner JR, Kim KS, Wang T, Coyne CB. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. The Journal of Biological Chemistry. 284: 6486-94. PMID 19122199 DOI: 10.1074/jbc.M807547200  0.96
2009 Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, Rao R. PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Proceedings of the National Academy of Sciences of the United States of America. 106: 61-6. PMID 19114660 DOI: 10.1073/pnas.0802741106  0.96
2009 Liu S, Yang W, Shen L, Turner JR, Coyne CB, Wang T. Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. Journal of Virology. 83: 2011-4. PMID 19052094 DOI: 10.1128/JVI.01888-08  0.96
2009 Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 136: 551-63. PMID 19027740 DOI: 10.1053/j.gastro.2008.10.081  0.96
2009 Elias BC, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, Turner JR, Naren A, Desiderio DM, Rao R. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. The Journal of Biological Chemistry. 284: 1559-69. PMID 19017651 DOI: 10.1074/jbc.M804783200  0.96
2009 Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology. 136: 236-46. PMID 18996125 DOI: 10.1053/j.gastro.2008.10.011  0.96
2008 Shen L, Turner JR. Intercellular junctions: actin the PARt. Current Biology : Cb. 18: R1014-7. PMID 19000799 DOI: 10.1016/j.cub.2008.10.010  0.96
2008 Gill RK, Shen L, Turner JR, Saksena S, Alrefai WA, Pant N, Esmaili A, Dwivedi A, Ramaswamy K, Dudeja PK. Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G700-8. PMID 18669621 DOI: 10.1152/ajpgi.90362.2008  0.96
2008 Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. The Journal of Cell Biology. 181: 683-95. PMID 18474622 DOI: 10.1083/jcb.200711165  0.96
2008 Wang Y, Zhu X, Wu G, Shen L, Chen B. Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice. Journal of Lipid Research. 49: 1640-5. PMID 18458046 DOI: 10.1194/jlr.M700446-JLR200  0.68
2008 Shen L, Zhu X, Wang Y, Zeng W, Wu G, Xue H, Chen B. Secreted human apolipoprotein(a) kringle IV-10 and kringle V inhibit angiogenesis and xenografted tumor growth. Biological Chemistry. 389: 135-41. PMID 18163888 DOI: 10.1515/BC.2008.016  0.68
2007 Coyne CB, Shen L, Turner JR, Bergelson JM. Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host & Microbe. 2: 181-92. PMID 18005733 DOI: 10.1016/j.chom.2007.07.003  0.96
2007 Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 132: 2383-94. PMID 17570213 DOI: 10.1053/j.gastro.2007.02.052  0.96
2006 Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. Journal of Cell Science. 119: 2095-106. PMID 16638813 DOI: 10.1242/jcs.02915  0.96
2006 Shen L, Turner JR. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G577-82. PMID 16537969 DOI: 10.1152/ajpgi.00439.2005  0.96
2005 Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science (New York, N.Y.). 309: 774-7. PMID 16051797 DOI: 10.1126/science.1112422  0.96
2005 Shen L, Turner JR. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Molecular Biology of the Cell. 16: 3919-36. PMID 15958494 DOI: 10.1091/mbc.E04-12-1089  0.96
2005 Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JR. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology. 128: 987-1001. PMID 15825080 DOI: 10.1053/j.gastro.2005.01.004  0.96
2004 Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Laboratory Investigation; a Journal of Technical Methods and Pathology. 84: 282-91. PMID 14767487 DOI: 10.1038/labinvest.3700050  0.96
2002 Algeciras-Schimnich A, Shen L, Barnhart BC, Murmann AE, Burkhardt JK, Peter ME. Molecular ordering of the initial signaling events of CD95. Molecular and Cellular Biology. 22: 207-20. PMID 11739735 DOI: 10.1128/MCB.22.1.207-220.2002  0.96
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