Douglas W. DeSimone - Publications

Affiliations: 
Cell Biology University of Virginia, Charlottesville, VA 
Area:
Human Development, Cell Biology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Comlekoglu T, Dzamba BJ, Pacheco GG, Shook DR, Sego TJ, Glazier JA, Peirce SM, DeSimone DW. Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of Xenopus mesendoderm. Biology Open. 13. PMID 39162010 DOI: 10.1242/bio.060615  0.824
2023 Comlekoglu T, Dzamba BJ, Pacheco GG, Shook DR, Sego TJ, Glazier JA, Peirce SM, DeSimone DW. Modeling the roles of cohesotaxis, cell-intercalation, and tissue geometry in collective cell migration of mesendoderm. Biorxiv : the Preprint Server For Biology. PMID 37904937 DOI: 10.1101/2023.10.16.562601  0.824
2023 Sego TJ, Comlekoglu T, Peirce SM, Desimone DW, Glazier JA. General, open-source vertex modeling in biological applications using Tissue Forge. Scientific Reports. 13: 17886. PMID 37857673 DOI: 10.1038/s41598-023-45127-x  0.791
2023 Sego TJ, Comlekoglu T, Peirce SM, Desimone D, Glazier JA. General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge. Research Square. PMID 37214822 DOI: 10.21203/rs.3.rs-2886960/v1  0.791
2022 Shook DR, Wen JWH, Rolo A, O'Hanlon M, Francica B, Dobbins D, Skoglund P, DeSimone DW, Winklbauer R, Keller RE. Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians. Elife. 11. PMID 35404236 DOI: 10.7554/eLife.57642  0.784
2021 Watanabe H, Belyea BC, Paxton RL, Li M, Dzamba BJ, DeSimone DW, Gomez RA, Sequeira-Lopez MLS. The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis. Circulation Research. PMID 33993729 DOI: 10.1161/CIRCRESAHA.120.318711  0.782
2018 Dzamba BJ, DeSimone DW. Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues. Current Topics in Developmental Biology. 130: 245-274. PMID 29853179 DOI: 10.1016/Bs.Ctdb.2018.03.006  0.849
2017 Sonavane PR, Wang C, Dzamba B, Weber GF, Periasamy A, DeSimone DW. Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation. Development (Cambridge, England). PMID 28982683 DOI: 10.1242/Dev.155200  0.822
2014 Rozario T, Mead PE, DeSimone DW. Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis. Mechanisms of Development. 133: 203-17. PMID 25173804 DOI: 10.1016/J.Mod.2014.07.004  0.814
2014 DeSimone DW, Horwitz AR. Cell Biology. Many modes of motility. Science (New York, N.Y.). 345: 1002-3. PMID 25170137 DOI: 10.1126/Science.1259176  0.45
2014 Bjerke MA, Dzamba BJ, Wang C, DeSimone DW. FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. Developmental Biology. 394: 340-56. PMID 25127991 DOI: 10.1016/J.Ydbio.2014.07.023  0.837
2012 Xu G, Wei S, White JM, DeSimone DW. Identification and characterization of ADAM41, a novel ADAM metalloproteinase in Xenopus. The International Journal of Developmental Biology. 56: 333-9. PMID 22811267 DOI: 10.1387/Ijdb.113444Gx  0.771
2012 Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3359-64. PMID 22331870 DOI: 10.1073/Pnas.1115967109  0.705
2012 Wei S, Xu G, Bridges LC, Williams P, Nakayama T, Shah A, Grainger RM, White JM, DeSimone DW. Roles of ADAM13-regulated Wnt activity in early Xenopus eye development. Developmental Biology. 363: 147-54. PMID 22227340 DOI: 10.1016/J.Ydbio.2011.12.031  0.771
2012 Weber GF, Bjerke MA, DeSimone DW. A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration. Developmental Cell. 22: 104-15. PMID 22169071 DOI: 10.1016/J.Devcel.2011.10.013  0.836
2011 Schwarzbauer JE, DeSimone DW. Fibronectins, their fibrillogenesis, and in vivo functions. Cold Spring Harbor Perspectives in Biology. 3. PMID 21576254 DOI: 10.1101/Cshperspect.A005041  0.631
2011 Weber GF, Bjerke MA, DeSimone DW. Integrins and cadherins join forces to form adhesive networks. Journal of Cell Science. 124: 1183-93. PMID 21444749 DOI: 10.1242/Jcs.064618  0.841
2011 Weber G, Bjerke MA, DeSimone DW. Erratum: Integrins and cadherins join forces to form adhesive networks Journal of Cell Science. 124. DOI: 10.1242/Jcs.091074  0.638
2010 Wei S, Xu G, Bridges LC, Williams P, White JM, DeSimone DW. ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling. Developmental Cell. 19: 345-52. PMID 20708595 DOI: 10.1016/J.Devcel.2010.07.012  0.796
2010 Wei S, Whittaker CA, Xu G, Bridges LC, Shah A, White JM, Desimone DW. Conservation and divergence of ADAM family proteins in the Xenopus genome. Bmc Evolutionary Biology. 10: 211. PMID 20630080 DOI: 10.1186/1471-2148-10-211  0.767
2010 Rozario T, DeSimone DW. The extracellular matrix in development and morphogenesis: a dynamic view. Developmental Biology. 341: 126-40. PMID 19854168 DOI: 10.1016/J.Ydbio.2009.10.026  0.845
2009 Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW. Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Developmental Cell. 16: 421-32. PMID 19289087 DOI: 10.1016/J.Devcel.2009.01.008  0.84
2009 Rozario T, Dzamba B, Weber GF, Davidson LA, DeSimone DW. The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo. Developmental Biology. 327: 386-98. PMID 19138684 DOI: 10.1016/J.Ydbio.2008.12.025  0.825
2008 Davidson LA, Dzamba BD, Keller R, Desimone DW. Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2684-92. PMID 18629871 DOI: 10.1002/Dvdy.21600  0.829
2008 Schwartz MA, DeSimone DW. Cell adhesion receptors in mechanotransduction. Current Opinion in Cell Biology. 20: 551-6. PMID 18583124 DOI: 10.1016/J.Ceb.2008.05.005  0.667
2008 Cousin H, Desimone DW, Alfandari D. PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis. Developmental Biology. 319: 86-99. PMID 18495106 DOI: 10.1016/J.Ydbio.2008.04.007  0.827
2007 Thorne BC, Bailey AM, DeSimone DW, Peirce SM. Agent-based modeling of multicell morphogenic processes during development. Birth Defects Research. Part C, Embryo Today : Reviews. 81: 344-53. PMID 18228259 DOI: 10.1002/Bdrc.20106  0.399
2007 Robertson SH, Smith CK, Langhans AL, McLinden SE, Oberhardt MA, Jakab KR, Dzamba B, DeSimone DW, Papin JA, Peirce SM. Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior. Bmc Systems Biology. 1: 46. PMID 17953751 DOI: 10.1186/1752-0509-1-46  0.823
2007 DeSimone DW, Dzamba B, Davidson LA. Using Xenopus embryos to investigate integrin function. Methods in Enzymology. 426: 403-14. PMID 17697893 DOI: 10.1016/S0076-6879(07)26017-3  0.833
2006 Davidson LA, Marsden M, Keller R, Desimone DW. Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension. Current Biology : Cb. 16: 833-44. PMID 16682346 DOI: 10.1016/J.Cub.2006.03.038  0.829
2005 DeSimone DW, Davidson L, Marsden M, Alfandari D. The Xenopus embryo as a model system for studies of cell migration. Methods in Molecular Biology (Clifton, N.J.). 294: 235-45. PMID 15576916 DOI: 10.1385/1-59259-860-9:235  0.835
2004 Davidson LA, Keller R, DeSimone DW. Assembly and remodeling of the fibrillar fibronectin extracellular matrix during gastrulation and neurulation in Xenopus laevis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 231: 888-95. PMID 15517579 DOI: 10.1002/Dvdy.20217  0.819
2004 Longo D, Peirce SM, Skalak TC, Davidson L, Marsden M, Dzamba B, DeSimone DW. Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis. Developmental Biology. 271: 210-22. PMID 15196962 DOI: 10.1016/J.Ydbio.2004.03.021  0.828
2004 Davidson LA, Keller R, DeSimone D. Patterning and tissue movements in a novel explant preparation of the marginal zone of Xenopus laevis. Gene Expression Patterns : Gep. 4: 457-66. PMID 15183313 DOI: 10.1016/J.Modgep.2004.01.001  0.8
2003 Alfandari D, Cousin H, Gaultier A, Hoffstrom BG, DeSimone DW. Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin. Developmental Biology. 260: 449-64. PMID 12921745 DOI: 10.1016/S0012-1606(03)00277-X  0.824
2003 Marsden M, DeSimone DW. Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus. Current Biology : Cb. 13: 1182-91. PMID 12867028 DOI: 10.1016/S0960-9822(03)00433-0  0.856
2003 Na J, Marsden M, DeSimone DW. Differential regulation of cell adhesive functions by integrin alpha subunit cytoplasmic tails in vivo. Journal of Cell Science. 116: 2333-43. PMID 12711704 DOI: 10.1242/Jcs.00445  0.815
2002 Smith KM, Gaultier A, Cousin H, Alfandari D, White JM, DeSimone DW. The cysteine-rich domain regulates ADAM protease function in vivo. The Journal of Cell Biology. 159: 893-902. PMID 12460986 DOI: 10.1083/Jcb.200206023  0.787
2002 Davidson LA, Hoffstrom BG, Keller R, DeSimone DW. Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha(5)beta(1), fibronectin, and tissue geometry. Developmental Biology. 242: 109-29. PMID 11820810 DOI: 10.1006/Dbio.2002.0537  0.81
2001 Marsden M, DeSimone DW. Regulation of cell polarity, radial intercalation and epiboly in Xenopus: Novel roles for integrin and fibronectin Development. 128: 3635-3647. PMID 11566866  0.503
2001 Alfandari D, Cousin H, Gaultier A, Smith K, White JM, Darribère T, DeSimone DW. Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration Current Biology. 11: 918-930. PMID 11448768 DOI: 10.1016/S0960-9822(01)00263-9  0.846
2000 Lallier TE, DeSimone DW. Separation of neural induction and neurulation in xenopus Developmental Biology. 225: 135-150. PMID 10964470 DOI: 10.1006/Dbio.2000.9833  0.419
2000 Cohen MW, Hoffstrom BG, DeSimone DW. Active zones on motor nerve terminals contain alpha 3beta 1 integrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4912-21. PMID 10864949  0.711
2000 Cohen MW, Hoffstrom BG, DeSimone DW. Active Zones on Motor Nerve Terminals Contain α3β1 Integrin The Journal of Neuroscience. 20: 4912-4921. DOI: 10.1523/Jneurosci.20-13-04912.2000  0.727
1998 Whittaker CA, Desimone DW. Molecular cloning and developmental expression of the Xenopus homolog of integrin α4a Annals of the New York Academy of Sciences. 857: 56-73. PMID 9917832 DOI: 10.1111/J.1749-6632.1998.Tb10107.X  0.654
1998 Urry LA, Whittaker CA, Duquette M, Lawler J, DeSimone DW. Thrombospondins in early Xenopus embryos: Dynamic patterns of expression suggest diverse roles in nervous system, notochord, and muscle development Developmental Dynamics. 211: 390-407. PMID 9566958 DOI: 10.1002/(Sici)1097-0177(199804)211:4<390::Aid-Aja10>3.0.Co;2-8  0.652
1997 Meng F, Whittaker CA, Ransom DG, DeSimone DW. Cloning and characterization of cDNAs encoding the integrin α2 and α3 subunits from Xenopus laevis Mechanisms of Development. 67: 141-155. PMID 9392512 DOI: 10.1016/S0925-4773(97)00108-1  0.774
1997 Alfandari D, Wolfsberg TG, White JM, DeSimone DW. ADAM 13: A novel ADAM expressed in somitic mesoderm and neural crest cells during Xenopus laevis development Developmental Biology. 182: 314-330. PMID 9070330 DOI: 10.1006/Dbio.1996.8458  0.777
1997 Desimone DW, Ramos JW, Hoffstromi EG, Kateeshock SJ, Hens MD. Spatial regulation of integr1n adhesive function in early development Faseb Journal. 11.  0.436
1996 Alfandari D, Ramos J, Clavilier L, DeSimone DW, Darribère T. The RGD-dependent and the Hep II binding domains of fibronectin govern the adhesive behaviors of amphibian embryonic cells Mechanisms of Development. 56: 83-92. PMID 8798149 DOI: 10.1016/0925-4773(96)00513-8  0.839
1996 Ramos JW, Whittaker CA, DeSimone DW. Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation Development. 122: 2873-2883. PMID 8787760  0.472
1996 Ramos JW, DeSimone DW. Xenopus embryonic cell adhesion to fibronectin: Position-specific activation of RGD/synergy site-dependent migratory behavior at gastrulation Journal of Cell Biology. 134: 227-240. PMID 8698817 DOI: 10.1083/Jcb.134.1.227  0.756
1995 Hens MD, DeSimone DW. Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis Developmental Biology. 170: 274-288. PMID 7649362 DOI: 10.1006/Dbio.1995.1214  0.477
1995 Alfandari D, Whittaker CA, Desimone DW, Darribère T. Integrin αv subunit is expressed on mesodermal cell surfaces during amphibian gastrulation Developmental Biology. 170: 249-261. PMID 7649360 DOI: 10.1006/Dbio.1995.1212  0.797
1995 Joos TO, Whittaker CA, Meng F, DeSimone DW, Gnau V, Hausen P. Integrin α5 during early development of Xenopus laevis Mechanisms of Development. 50: 187-199. PMID 7619730 DOI: 10.1016/0925-4773(94)00335-K  0.733
1994 DeSimone DW. Adhesion and matrix in vertebrate development Current Opinion in Cell Biology. 6: 747-751. PMID 7833054 DOI: 10.1016/0955-0674(94)90103-1  0.497
1993 Lawler J, Duquette M, Whittaker CA, Adams JC, McHenry K, DeSimone DW. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family Journal of Cell Biology. 120: 1059-1067. PMID 8432726 DOI: 10.1083/Jcb.120.4.1059  0.575
1993 Ransom DG, Hens MD, DeSimone DW. Integrin expression in early amphibian embryos: CDNA cloning and characterization of Xenopus β1, β2, β3, and β6 subunits Developmental Biology. 160: 265-275. PMID 7693527 DOI: 10.1006/Dbio.1993.1304  0.738
1992 DeSimone DW, Norton PA, Hynes RO. Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos Developmental Biology. 149: 357-369. PMID 1730390 DOI: 10.1016/0012-1606(92)90291-N  0.547
1992 Johnson KE, Boucaut JC, DeSimone DW. Role of the extracellular matrix in amphibian gastrulation Current Topics in Developmental Biology. 27: 91-127. PMID 1424768 DOI: 10.1016/S0070-2153(08)60533-5  0.463
1991 Desimone DW, Johnson KE. Chapter 27 The Xenopus Embryo as a Model System for the Study of Cell-Extracellular Matrix Interactions Methods in Cell Biology. 36: 527-539. PMID 1811150 DOI: 10.1016/S0091-679X(08)60295-2  0.493
1987 DeSimone DW, Stepp MA, Patel RS, Hynes RO. The integrin family of cell surface receptors Biochemical Society Transactions. 15: 789-791. PMID 2826269 DOI: 10.1042/Bst0150789A  0.527
1986 DeSimone DW, Spiegel M. Concanavalin A and wheat germ agglutinin binding to sea urchin embryo basal laminae. Roux's Archives of Developmental Biology : the Official Organ of the Edbo. 195: 433-444. PMID 28305405 DOI: 10.1007/BF00375747  0.689
1986 Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell. 46: 271-82. PMID 3487386 DOI: 10.1016/0092-8674(86)90744-0  0.529
1986 DeSimone DW, Spiegel M. Wheat germ agglutinin binding to the micromeres and primary mesenchyme cells of sea urchin embryos Developmental Biology. 114: 336-346. DOI: 10.1016/0012-1606(86)90198-3  0.702
1986 DeSimone DW, Spiegel M. Concanavalin A and wheat germ agglutinin binding to sea urchin embryo basal laminae Roux's Archives of Developmental Biology. 195: 433-444. DOI: 10.1007/BF00375747  0.689
1985 DeSimone DW, Spiegel E, Spiegel M. The biochemical identification of fibronectin in the sea urchin embryo Biochemical and Biophysical Research Communications. 133: 183-188. PMID 4074361 DOI: 10.1016/0006-291X(85)91858-3  0.668
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