| Year |
Citation |
Score |
| 2020 |
Kamerzell TJ, Middaugh CR. Prediction Machines: Applied Machine Learning for Therapeutic Protein Design and Development. Journal of Pharmaceutical Sciences. PMID 33278409 DOI: 10.1016/j.xphs.2020.11.034 |
0.723 |
|
| 2020 |
Jain A, Hu G, Kumar Ratnakaram SS, Johnson DK, Picking WD, Picking WL, Middaugh CR. Preformulation Characterization and the Effect of Ionic Excipients on the Stability of a Novel DB Fusion Protein. Journal of Pharmaceutical Sciences. PMID 32916136 DOI: 10.1016/J.Xphs.2020.09.008 |
0.485 |
|
| 2019 |
Larson NR, Wei Y, Prajapati I, Chakraborty A, Peters B, Cavan Kalonia, Hudak S, Choudhary S, Esfandiary R, Dhar P, Schöneich C, Middaugh CR. Comparison of polysorbate 80 hydrolysis and oxidation on the aggregation of a monoclonal antibody. Journal of Pharmaceutical Sciences. PMID 31758949 DOI: 10.1016/J.Xphs.2019.10.069 |
0.694 |
|
| 2019 |
Prajapati I, Peters BH, Larson NR, Wei Y, Choudhary S, Kalonia C, Hudak S, Esfandiary R, Middaugh CR, Schöneich C. Cis/trans isomerization of unsaturated fatty acids in polysorbate 80 during light exposure of a monoclonal antibody-containing formulation. Journal of Pharmaceutical Sciences. PMID 31715179 DOI: 10.1016/J.Xphs.2019.10.068 |
0.65 |
|
| 2019 |
Hu Y, Arora J, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1. Journal of Pharmaceutical Sciences. PMID 31201906 DOI: 10.1016/J.Xphs.2019.06.005 |
0.726 |
|
| 2019 |
Hu Y, Toth RT, Joshi SB, Esfandiary R, Middaugh CR, Volkin DB, Weis DD. Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2. Journal of Pharmaceutical Sciences. PMID 31195015 DOI: 10.1016/J.Xphs.2019.06.001 |
0.715 |
|
| 2018 |
Toprani VM, Cheng Y, Wahome N, Khasa H, Kueltzo LA, Schwartz RM, Middaugh CR, Joshi SB, Volkin DB. Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-like Particle Vaccine Candidate. Journal of Pharmaceutical Sciences. PMID 29883665 DOI: 10.1016/J.Xphs.2018.05.022 |
0.75 |
|
| 2018 |
Angalakurthi SK, Tenorio CA, Blaber M, Middaugh CR. Investigating the Dynamics and Polyanion Binding Sites of Fibroblast Growth Factor-1 Using Hydrogen-Deuterium Exchange Mass Spectrometry. Protein Science : a Publication of the Protein Society. PMID 29645318 DOI: 10.1002/Pro.3423 |
0.318 |
|
| 2017 |
Toth RT, Pace SE, Mills BJ, Joshi SB, Esfandiary R, Middaugh CR, Weis DD, Volkin DB. Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody. Journal of Pharmaceutical Sciences. PMID 29269271 DOI: 10.1016/J.Xphs.2017.12.009 |
0.697 |
|
| 2017 |
Toth RT, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD. Correction to Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements. Analytical Chemistry. 89: 13673. PMID 29210567 DOI: 10.1021/acs.analchem.7b04690 |
0.639 |
|
| 2017 |
Wei Y, Wahome N, Kumar P, Whitaker N, Picking WL, Middaugh CR. Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System from Bacillus anthracis. Journal of Pharmaceutical Sciences. PMID 29045884 DOI: 10.1016/J.Xphs.2017.10.013 |
0.778 |
|
| 2017 |
Pace SE, Joshi SB, Esfandiary R, Stadelman R, Bishop SM, Middaugh CR, Fisher M, Volkin DB. The Use of a GroEL-BLI Biosensor to Rapidly Assess Pre-Aggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles. Journal of Pharmaceutical Sciences. PMID 29037466 DOI: 10.1016/J.Xphs.2017.10.010 |
0.737 |
|
| 2017 |
Toprani VM, Hickey JM, Sahni N, Toth RT, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Structural characterization and physicochemical stability profile of a double mutant heat labile toxin (dmLT) protein based adjuvant. Journal of Pharmaceutical Sciences. PMID 28780391 DOI: 10.1016/J.Xphs.2017.07.019 |
0.306 |
|
| 2017 |
Toth Iv RT, Mills BJ, Joshi SB, Esfandiary R, Bishop SM, Middaugh CR, Volkin DB, Weis DD. An Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange Mass Spectrometry Measurements. Analytical Chemistry. PMID 28753295 DOI: 10.1021/Acs.Analchem.7B01396 |
0.693 |
|
| 2017 |
Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta ML, Picking WL, Volkin DB, Mantis NJ, Middaugh CR. Evaluation of Lumazine Synthase from Bacillus anthracis as a Presentation Platform for Polyvalent Antigen Display. Protein Science : a Publication of the Protein Society. PMID 28736824 DOI: 10.1002/Pro.3243 |
0.787 |
|
| 2017 |
Whitaker N, Xiong J, Pace SE, Kumar V, Middaugh CR, Joshi SB, Volkin DB. A Formulation Development Approach to Identify and Select Stable Ultra-High Concentration Monoclonal Antibody Formulations with Reduced Viscosities. Journal of Pharmaceutical Sciences. PMID 28668340 DOI: 10.1016/J.Xphs.2017.06.017 |
0.764 |
|
| 2017 |
Toprani VM, Sahni N, Hickey JM, Robertson GA, Middaugh CR, Joshi SB, Volkin DB. Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant. Vaccine. PMID 28551040 DOI: 10.1016/J.Vaccine.2017.03.101 |
0.352 |
|
| 2016 |
Arora J, Hu Y, Esfandiary R, Sathish HA, Bishop SM, Joshi SB, Middaugh CR, Volkin DB, Weis DD. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity. Mabs. 0. PMID 27560842 DOI: 10.1080/19420862.2016.1222342 |
0.722 |
|
| 2016 |
Kalonia C, Toprani V, Toth RT, Wahome N, Gabel I, Middaugh CR, Volkin DB. Effects of Protein Conformation, Apparent Solubility, and Protein-Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1 Monoclonal Antibody. The Journal of Physical Chemistry. B. PMID 27380437 DOI: 10.1021/Acs.Jpcb.6B03878 |
0.306 |
|
| 2016 |
Toprani VM, Joshi SB, Kueltzo LA, Schwartz RM, Middaugh CR, Volkin DB. A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development. Journal of Pharmaceutical Sciences. PMID 27368120 DOI: 10.1016/J.Xphs.2016.05.021 |
0.735 |
|
| 2016 |
Kim JH, Joshi SB, Esfandiary R, Iyer V, Bishop SM, Volkin DB, Middaugh CR. Improved Comparative Signature Diagrams to Evaluate Similarity of Storage Stability Profiles of Different IgG1 mAbs. Journal of Pharmaceutical Sciences. PMID 26886311 DOI: 10.1016/J.Xphs.2016.01.008 |
0.732 |
|
| 2016 |
More AS, Toprani VM, Okbazghi SZ, Kim JH, Joshi SB, Middaugh CR, Tolbert TJ, Volkin DB. Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms. Journal of Pharmaceutical Sciences. 105: 588-601. PMID 26869421 DOI: 10.1016/J.Xphs.2015.10.014 |
0.304 |
|
| 2015 |
Chen X, Choudhari SP, Kumar P, Toth RT, Kim JH, Van Roosmalen ML, Leenhouts K, Middaugh CR, Picking WL, Picking WD. Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles. Journal of Pharmaceutical Sciences. PMID 26422758 DOI: 10.1002/Jps.24659 |
0.305 |
|
| 2015 |
Arora J, Hickey JM, Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Weis DD, Volkin DB. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody. Mabs. 7: 525-39. PMID 25875351 DOI: 10.1080/19420862.2015.1029217 |
0.712 |
|
| 2015 |
Majumdar R, Esfandiary R, Bishop SM, Samra HS, Middaugh CR, Volkin DB, Weis DD. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life. Mabs. 7: 84-95. PMID 25524268 DOI: 10.4161/19420862.2014.985494 |
0.699 |
|
| 2014 |
Alsenaidy MA, Jain NK, Kim JH, Middaugh CR, Volkin DB. Protein comparability assessments and potential applicability of high throughput biophysical methods and data visualization tools to compare physical stability profiles. Frontiers in Pharmacology. 5: 39. PMID 24659968 DOI: 10.3389/Fphar.2014.00039 |
0.325 |
|
| 2014 |
Telikepalli SN, Kumru OS, Kalonia C, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions. Journal of Pharmaceutical Sciences. 103: 796-809. PMID 24452866 DOI: 10.1002/Jps.23839 |
0.675 |
|
| 2014 |
Qi W, Zeng Y, Orgel S, Francon A, Kim JH, Randolph TW, Carpenter JF, Middaugh CR. Preformulation study of highly purified inactivated polio vaccine, serotype 3. Journal of Pharmaceutical Sciences. 103: 140-51. PMID 24282078 DOI: 10.1002/Jps.23801 |
0.323 |
|
| 2014 |
Chaudhuri R, Cheng Y, Middaugh CR, Volkin DB. High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability. The Aaps Journal. 16: 48-64. PMID 24174400 DOI: 10.1208/S12248-013-9539-6 |
0.333 |
|
| 2013 |
Kramer RM, Zeng Y, Sahni N, Kueltzo LA, Schwartz RM, Srivastava IK, Crane L, Joshi SB, Volkin DB, Middaugh CR. Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions. Journal of Pharmaceutical Sciences. 102: 4305-14. PMID 24129946 DOI: 10.1002/Jps.23749 |
0.749 |
|
| 2013 |
Thakkar SV, Sahni N, Joshi SB, Kerwin BA, He F, Volkin DB, Middaugh CR. Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies. Protein Science : a Publication of the Protein Society. 22: 1295-305. PMID 23893936 DOI: 10.1002/Pro.2316 |
0.777 |
|
| 2013 |
Cheng W, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P, Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. Human Vaccines & Immunotherapeutics. 9: 2351-61. PMID 23880663 DOI: 10.4161/Hv.25788 |
0.303 |
|
| 2013 |
Wang T, Kumru OS, Yi L, Wang YJ, Zhang J, Kim JH, Joshi SB, Middaugh CR, Volkin DB. Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment. Journal of Pharmaceutical Sciences. 102: 2520-37. PMID 23824562 DOI: 10.1002/Jps.23645 |
0.353 |
|
| 2013 |
Manikwar P, Majumdar R, Hickey JM, Thakkar SV, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Weis DD, Volkin DB. Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry. Journal of Pharmaceutical Sciences. 102: 2136-51. PMID 23620222 DOI: 10.1002/Jps.23543 |
0.77 |
|
| 2013 |
Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Human Vaccines & Immunotherapeutics. 9: 744-52. PMID 23563512 DOI: 10.4161/Hv.22998 |
0.304 |
|
| 2013 |
Fakhari A, Phan Q, Thakkar SV, Middaugh CR, Berkland C. Hyaluronic acid nanoparticles titrate the viscoelastic properties of viscosupplements. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 5123-31. PMID 23514620 DOI: 10.1021/La304575X |
0.726 |
|
| 2013 |
Choudhari SP, Kramer R, Barta ML, Greenwood JC, Geisbrecht BV, Joshi SB, Picking WD, Middaugh CR, Picking WL. Studies of the conformational stability of invasion plasmid antigen B from Shigella. Protein Science : a Publication of the Protein Society. 22: 666-70. PMID 23494968 DOI: 10.1002/Pro.2249 |
0.333 |
|
| 2013 |
Hu L, Joshi SB, Liyanage MR, Pansalawatta M, Alderson MR, Tate A, Robertson G, Maisonneuve J, Volkin DB, Middaugh CR. Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. Journal of Pharmaceutical Sciences. 102: 387-400. PMID 23161162 DOI: 10.1002/Jps.23375 |
0.337 |
|
| 2013 |
Liu J, Blasie CA, Shi S, Joshi SB, Middaugh CR, Volkin DB. Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2). Journal of Pharmaceutical Sciences. 102: 827-41. PMID 23160921 DOI: 10.1002/Jps.23360 |
0.351 |
|
| 2012 |
Thakkar SV, Kim JH, Samra HS, Sathish HA, Bishop SM, Joshi SB, Volkin DB, Middaugh CR. Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody. Journal of Pharmaceutical Sciences. 101: 4444-57. PMID 23060088 DOI: 10.1002/Jps.23332 |
0.776 |
|
| 2012 |
Hu L, Joshi SB, Andra KK, Thakkar SV, Volkin DB, Bann JG, Middaugh CR. Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue. Journal of Pharmaceutical Sciences. 101: 4118-28. PMID 22911632 DOI: 10.1002/Jps.23294 |
0.797 |
|
| 2012 |
Thakkar SV, Allegre KM, Joshi SB, Volkin DB, Middaugh CR. An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations. Journal of Pharmaceutical Sciences. 101: 3051-61. PMID 22581726 DOI: 10.1002/Jps.23188 |
0.774 |
|
| 2012 |
Thakkar SV, Joshi SB, Jones ME, Sathish HA, Bishop SM, Volkin DB, Middaugh CR. Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences. 101: 3062-77. PMID 22581714 DOI: 10.1002/Jps.23187 |
0.773 |
|
| 2012 |
Iyer V, Hu L, Liyanage MR, Esfandiary R, Reinisch C, Meinke A, Maisonneuve J, Volkin DB, Joshi SB, Middaugh CR. Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae. Journal of Pharmaceutical Sciences. 101: 3078-90. PMID 22538529 DOI: 10.1002/Jps.23175 |
0.756 |
|
| 2012 |
Shi S, Liu J, Joshi SB, Krasnoperov V, Gill P, Middaugh CR, Volkin DB. Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA. Journal of Pharmaceutical Sciences. 101: 1969-84. PMID 22411527 DOI: 10.1002/Jps.23096 |
0.36 |
|
| 2012 |
Cheng W, Joshi SB, He F, Brems DN, He B, Kerwin BA, Volkin DB, Middaugh CR. Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. Journal of Pharmaceutical Sciences. 101: 1701-20. PMID 22323186 DOI: 10.1002/Jps.23076 |
0.328 |
|
| 2012 |
Bhambhani A, Kissmann JM, Joshi SB, Volkin DB, Kashi RS, Middaugh CR. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions. Journal of Pharmaceutical Sciences. 101: 1120-35. PMID 22147527 DOI: 10.1002/Jps.23008 |
0.815 |
|
| 2012 |
Alsenaidy MA, Wang T, Kim JH, Joshi SB, Lee J, Blaber M, Volkin DB, Middaugh CR. An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Science : a Publication of the Protein Society. 21: 418-32. PMID 22113934 DOI: 10.1002/Pro.2008 |
0.305 |
|
| 2011 |
Hu L, Olsen C, Maddux N, Joshi SB, Volkin DB, Middaugh CR. Investigation of protein conformational stability employing a multimodal spectrometer. Analytical Chemistry. 83: 9399-405. PMID 22047496 DOI: 10.1021/Ac201995C |
0.352 |
|
| 2011 |
Khondee S, Olsen CM, Zeng Y, Middaugh CR, Berkland C. Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2). Biomacromolecules. 12: 3880-94. PMID 21954860 DOI: 10.1021/Bm2007967 |
0.306 |
|
| 2011 |
Kamerzell TJ, Esfandiary R, Joshi SB, Middaugh CR, Volkin DB. Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development. Advanced Drug Delivery Reviews. 63: 1118-59. PMID 21855584 DOI: 10.1016/J.Addr.2011.07.006 |
0.813 |
|
| 2011 |
Maddux NR, Joshi SB, Volkin DB, Ralston JP, Middaugh CR. Multidimensional methods for the formulation of biopharmaceuticals and vaccines. Journal of Pharmaceutical Sciences. 100: 4171-97. PMID 21647886 DOI: 10.1002/Jps.22618 |
0.335 |
|
| 2011 |
Kissmann J, Joshi SB, Haynes JR, Dokken L, Richardson C, Middaugh CR. H1N1 influenza virus-like particles: physical degradation pathways and identification of stabilizers. Journal of Pharmaceutical Sciences. 100: 634-45. PMID 20669328 DOI: 10.1002/Jps.22304 |
0.805 |
|
| 2010 |
Markham AP, Barrett BS, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR. Formulation and immunogenicity of a potential multivalent type III secretion system-based protein vaccine. Journal of Pharmaceutical Sciences. 99: 4497-509. PMID 20845449 DOI: 10.1002/Jps.22195 |
0.805 |
|
| 2010 |
Barrett BS, Markham AP, Esfandiary R, Picking WL, Picking WD, Joshi SB, Middaugh CR. Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates. Journal of Pharmaceutical Sciences. 99: 4488-96. PMID 20845448 DOI: 10.1002/Jps.22180 |
0.799 |
|
| 2010 |
Esfandiary R, Yee L, Ohtake S, Martin RA, Truong-Le VL, Lechuga-Ballesteros D, Moore DS, Joshi SB, Middaugh CR. Biophysical characterization of rotavirus serotypes G1, G3 and G4. Human Vaccines. 6: 390-8. PMID 20534978 DOI: 10.4161/Hv.6.5.10963 |
0.719 |
|
| 2010 |
Samra HS, He F, Bhambhani A, Pipkin JD, Zimmerer R, Joshi SB, Middaugh CR. The effects of substituted cyclodextrins on the colloidal and conformational stability of selected proteins. Journal of Pharmaceutical Sciences. 99: 2800-18. PMID 20049940 DOI: 10.1002/Jps.22053 |
0.323 |
|
| 2009 |
Esfandiary R, Hunjan JS, Lushington GH, Joshi SB, Middaugh CR. Temperature dependent 2nd derivative absorbance spectroscopy of aromatic amino acids as a probe of protein dynamics. Protein Science : a Publication of the Protein Society. 18: 2603-14. PMID 19827094 DOI: 10.1002/Pro.264 |
0.721 |
|
| 2009 |
Markham AP, Jaafar ZA, Kemege KE, Middaugh CR, Hefty PS. Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein. Biochemistry. 48: 10353-61. PMID 19769366 DOI: 10.1021/Bi901200Y |
0.797 |
|
| 2009 |
Cai S, He F, Samra HS, de la Maza LM, Bottazzi ME, Joshi SB, Middaugh CR. Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Molecular Pharmaceutics. 6: 1553-61. PMID 19650664 DOI: 10.1021/Mp900110Q |
0.344 |
|
| 2009 |
Zeng Y, Fan H, Chiueh G, Pham B, Martin R, Lechuga-Ballesteros D, Truong VL, Joshi SB, Middaugh CR. Towards development of stable formulations of a live attenuated bacterial vaccine: a preformulation study facilitated by a biophysical approach. Human Vaccines. 5: 322-31. PMID 19221516 DOI: 10.4161/Hv.5.5.7559 |
0.556 |
|
| 2009 |
Ramsey JD, Gill ML, Kamerzell TJ, Price ES, Joshi SB, Bishop SM, Oliver CN, Middaugh CR. Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability. Journal of Pharmaceutical Sciences. 98: 2432-47. PMID 19072858 DOI: 10.1002/Jps.21619 |
0.769 |
|
| 2009 |
Esfandiary R, Kickhoefer VA, Rome LH, Joshi SB, Middaugh CR. Structural stability of vault particles. Journal of Pharmaceutical Sciences. 98: 1376-86. PMID 18683860 DOI: 10.1002/Jps.21508 |
0.72 |
|
| 2009 |
Zheng K, Middaugh CR, Siahaan TJ. Evaluation of the physical stability of the EC5 domain of E-cadherin: Effects of pH, temperature, ionic strength, and disulfide bonds Journal of Pharmaceutical Sciences. 98: 63-73. PMID 18428798 DOI: 10.1002/Jps.21418 |
0.307 |
|
| 2008 |
Barrett BS, Picking WL, Picking WD, Middaugh CR. The response of type three secretion system needle proteins MxiH Δ5, BsaLΔ5, and PrgIΔ5 to temperature and pH Proteins: Structure, Function and Genetics. 73: 632-643. PMID 18491382 DOI: 10.1002/Prot.22085 |
0.776 |
|
| 2008 |
Brooks AE, Stricker SM, Joshi SB, Kamerzell TJ, Middaugh CR, Lewis RV. Properties of synthetic spider silk fibers based on Argiope aurantia MaSp2. Biomacromolecules. 9: 1506-10. PMID 18457450 DOI: 10.1021/Bm701124P |
0.723 |
|
| 2008 |
Salnikova MS, Middaugh CR, Rytting JH. Stability of lyophilized human growth hormone International Journal of Pharmaceutics. 358: 108-113. PMID 18394830 DOI: 10.1016/J.Ijpharm.2008.02.022 |
0.321 |
|
| 2008 |
Kissmann J, Ausar SF, Rudolph A, Braun C, Cape SP, Sievers RE, Federspiel MJ, Joshi SB, Middaugh CR. Stabilization of measles virus for vaccine formulation. Human Vaccines. 4: 350-9. PMID 18382143 DOI: 10.4161/Hv.4.5.5863 |
0.795 |
|
| 2008 |
Peek LJ, Middaugh CR, Berkland C. Nanotechnology in vaccine delivery. Advanced Drug Delivery Reviews. 60: 915-28. PMID 18325628 DOI: 10.1016/J.Addr.2007.05.017 |
0.732 |
|
| 2008 |
Kissmann J, Ausar SF, Foubert TR, Brock J, Switzer MH, Detzi EJ, Vedvick TS, Middaugh CR. Physical stabilization of norwalk virus-like particles Journal of Pharmaceutical Sciences. 97: 4208-4218. PMID 18300304 DOI: 10.1002/Jps.21315 |
0.806 |
|
| 2008 |
Kamerzell TJ, Ramsey JD, Middaugh CR. Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability. The Journal of Physical Chemistry. B. 112: 3240-50. PMID 18284232 DOI: 10.1021/Jp710061A |
0.77 |
|
| 2008 |
Kamerzell TJ, Middaugh CR. The complex inter-relationships between protein flexibility and stability. Journal of Pharmaceutical Sciences. 97: 3494-517. PMID 18186490 DOI: 10.1002/Jps.21269 |
0.778 |
|
| 2008 |
Markham AP, Birket SE, Picking WD, Picking WL, Middaugh CR. pH sensitivity of type III secretion system tip proteins. Proteins. 71: 1830-42. PMID 18175320 DOI: 10.1002/Prot.21864 |
0.819 |
|
| 2008 |
Joshi SB, Kamerzell TJ, McNown C, Middaugh CR. The interaction of heparin/polyanions with bovine, porcine, and human growth hormone. Journal of Pharmaceutical Sciences. 97: 1368-85. PMID 17705152 DOI: 10.1002/Jps.21056 |
0.764 |
|
| 2007 |
Kamerzell TJ, Middaugh CR. Two-dimensional correlation spectroscopy reveals coupled immunoglobulin regions of differential flexibility that influence stability. Biochemistry. 46: 9762-73. PMID 17676765 DOI: 10.1021/Bi700645K |
0.777 |
|
| 2007 |
Birket SE, Harrington AT, Espina M, Smith ND, Terry CM, Darboe N, Markham AP, Middaugh CR, Picking WL, Picking WD. Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri. Biochemistry. 46: 8128-37. PMID 17571858 DOI: 10.1021/Bi700099C |
0.809 |
|
| 2007 |
Brandau DT, Joshi SB, Smalter AM, Kim S, Steadman B, Middaugh CR. Stability of the Clostridium botulinum type A neurotoxin complex: an empirical phase diagram based approach. Molecular Pharmaceutics. 4: 571-82. PMID 17552543 DOI: 10.1021/mp0601244 |
0.303 |
|
| 2007 |
Thyagarajapuram N, Olsen D, Middaugh CR. Stabilization of proteins by recombinant human gelatins Journal of Pharmaceutical Sciences. 96: 3304-3315. PMID 17542020 DOI: 10.1002/Jps.20980 |
0.817 |
|
| 2007 |
Kamerzell TJ, Joshi SB, McClean D, Peplinskie L, Toney K, Papac D, Li M, Middaugh CR. Parathyroid hormone is a heparin/polyanion binding protein: binding energetics and structure modification. Protein Science : a Publication of the Protein Society. 16: 1193-203. PMID 17525467 DOI: 10.1110/Ps.062613807 |
0.765 |
|
| 2007 |
Thyagarajapuram N, Olsen D, Middaugh CR. The structure, stability, and complex behavior of recombinant human gelatins Journal of Pharmaceutical Sciences. 96: 3363-3378. PMID 17518362 DOI: 10.1002/Jps.21022 |
0.812 |
|
| 2007 |
Ausar SF, Espina M, Brock J, Thyagarayapuran N, Repetto R, Khandke L, Middaugh CR. High-throughput screening of stabilizers for respirator/syncytial virus: Identification of stabilizers and their effects on the conformational thermostability of viral particles Human Vaccines. 3: 94-103. PMID 17426457 |
0.305 |
|
| 2007 |
Fan H, Vitharana SN, Chen T, O'Keefe D, Middaugh CR. Effects of pH and polyanions on the thermal stability of fibroblast growth factor 20 Molecular Pharmaceutics. 4: 232-240. PMID 17397238 DOI: 10.1021/Mp060097H |
0.536 |
|
| 2007 |
Fan H, Li H, Zhang M, Middaugh CR. Effects of solutes on empirical phase diagrams of human fibroblast growth factor 1. Journal of Pharmaceutical Sciences. 96: 1490-503. PMID 17094138 DOI: 10.1002/Jps.20796 |
0.551 |
|
| 2007 |
Derrick T, Grillo AO, Vitharana SN, Jones L, Rexroad J, Shah A, Perkins M, Spitznagel TM, Middaugh CR. Effect of polyanions on the structure and stability of repifermin (keratinocyte growth factor-2). Journal of Pharmaceutical Sciences. 96: 761-76. PMID 17094125 DOI: 10.1002/Jps.20797 |
0.8 |
|
| 2007 |
Harn N, Allan C, Oliver C, Middaugh CR. Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability. Journal of Pharmaceutical Sciences. 96: 532-46. PMID 17083094 DOI: 10.1002/Jps.20753 |
0.797 |
|
| 2007 |
Peek LJ, Martin TT, Elk Nation C, Pegram SA, Middaugh CR. Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants. Journal of Pharmaceutical Sciences. 96: 547-57. PMID 17080408 DOI: 10.1002/Jps.20762 |
0.782 |
|
| 2007 |
Peek LJ, Brey RN, Middaugh CR. A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine. Journal of Pharmaceutical Sciences. 96: 44-60. PMID 16998874 DOI: 10.1002/Jps.20675 |
0.779 |
|
| 2006 |
Kamerzell TJ, Unruh JR, Johnson CK, Middaugh CR. Conformational flexibility, hydration and state parameter fluctuations of fibroblast growth factor-10: effects of ligand binding. Biochemistry. 45: 15288-300. PMID 17176051 DOI: 10.1021/Bi061712Q |
0.754 |
|
| 2006 |
Lucas LH, Ersoy BA, Kueltzo LA, Joshi SB, Brandau DT, Thyagarajapuram N, Peek LJ, Middaugh CR. Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions. Protein Science : a Publication of the Protein Society. 15: 2228-43. PMID 16963649 DOI: 10.1110/Ps.062133706 |
0.801 |
|
| 2006 |
Ruponen M, Braun CS, Middaugh CR. Biophysical characterization of polymeric and liposomal gene delivery systems using empirical phase diagrams. Journal of Pharmaceutical Sciences. 95: 2101-14. PMID 16883552 DOI: 10.1002/jps.20621 |
0.791 |
|
| 2006 |
Guo J, Harn N, Robbins A, Dougherty R, Middaugh CR. Stability of helix-rich proteins at high concentrations. Biochemistry. 45: 8686-96. PMID 16834343 DOI: 10.1021/Bi060525P |
0.776 |
|
| 2006 |
Peek LJ, Brandau DT, Jones LS, Joshi SB, Middaugh CR. A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine. Vaccine. 24: 5839-51. PMID 16735084 DOI: 10.1016/J.Vaccine.2006.04.067 |
0.763 |
|
| 2006 |
Rexroad J, Martin TT, McNeilly D, Godwin S, Middaugh CR. Thermal stability of adenovirus type 2 as a function of pH. Journal of Pharmaceutical Sciences. 95: 1469-79. PMID 16724322 DOI: 10.1002/Jps.20617 |
0.795 |
|
| 2006 |
Ausar SF, Foubert TR, Hudson MH, Vedvick TS, Middaugh CR. conformational stability and disassembly of norwalk virus-like particles: Effect of ph and temperature Journal of Biological Chemistry. 281: 19478-19488. PMID 16675449 DOI: 10.1074/Jbc.M603313200 |
0.331 |
|
| 2006 |
Darboe N, Kenjale R, Picking WL, Picking WD, Middaugh CR. Physical characterization of MxiH and PrgI, the needle component of the type III secretion apparatus from Shigella and Salmonella. Protein Science : a Publication of the Protein Society. 15: 543-52. PMID 16501225 DOI: 10.1110/Ps.051733506 |
0.32 |
|
| 2006 |
Fan H, Kashi RS, Middaugh CR. Conformational lability of two molecular chaperones Hsc70 and gp96: effects of pH and temperature. Archives of Biochemistry and Biophysics. 447: 34-45. PMID 16487475 DOI: 10.1016/J.Abb.2006.01.012 |
0.564 |
|
| 2006 |
Rexroad J, Evans RK, Middaugh CR. Effect of pH and ionic strength on the physical stability of adenovirus type 5. Journal of Pharmaceutical Sciences. 95: 237-47. PMID 16372304 DOI: 10.1002/Jps.20496 |
0.8 |
|
| 2006 |
Jiang G, Joshi SB, Peek LJ, Brandau DT, Huang J, Ferriter MS, Woodley WD, Ford BM, Mar KD, Mikszta JA, Hwang CR, Ulrich R, Harvey NG, Middaugh CR, Sullivan VJ. Anthrax vaccine powder formulations for nasal mucosal delivery. Journal of Pharmaceutical Sciences. 95: 80-96. PMID 16315230 DOI: 10.1002/Jps.20484 |
0.777 |
|
| 2006 |
Kueltzo LA, Middaugh CR. Molten globule-lipid bilayer interactions and their implications for protein transport and aggregation Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability. 287-309. DOI: 10.1007/978-0-387-36063-8_13 |
0.71 |
|
| 2005 |
Ausar SF, Rexroad J, Frolov VG, Look JL, Konar N, Middaugh CR. Analysis of the thermal and pH stability of human respiratory syncytial virus. Molecular Pharmaceutics. 2: 491-9. PMID 16323956 DOI: 10.1021/Mp0500465 |
0.802 |
|
| 2005 |
Harn NR, Jeng YN, Kostelc JG, Middaugh CR. Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil. Journal of Pharmaceutical Sciences. 94: 2487-95. PMID 16200543 DOI: 10.1002/jps.20464 |
0.756 |
|
| 2005 |
Fan H, Ralston J, Dibiase M, Faulkner E, Middaugh CR. Solution behavior of IFN-beta-1a: an empirical phase diagram based approach. Journal of Pharmaceutical Sciences. 94: 1893-911. PMID 16052555 DOI: 10.1002/Jps.20410 |
0.525 |
|
| 2005 |
Lobo B, Ropp JD, Middaugh CR. The 1st annual meeting of the American Society of Gene Therapy. Expert Opinion On Investigational Drugs. 7: 1719-26. PMID 15991913 DOI: 10.1517/13543784.7.10.1719 |
0.708 |
|
| 2005 |
Braun CS, Fisher MT, Tomalia DA, Koe GS, Koe JG, Middaugh CR. A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes. Biophysical Journal. 88: 4146-58. PMID 15805171 DOI: 10.1529/Biophysj.104.055202 |
0.768 |
|
| 2005 |
Jones LS, Peek LJ, Power J, Markham A, Yazzie B, Middaugh CR. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. The Journal of Biological Chemistry. 280: 13406-14. PMID 15684430 DOI: 10.1074/Jbc.M500687200 |
0.807 |
|
| 2005 |
Braun CS, Vetro JA, Tomalia DA, Koe GS, Koe JG, Middaugh CR. Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. Journal of Pharmaceutical Sciences. 94: 423-36. PMID 15614818 DOI: 10.1002/Jps.20251 |
0.791 |
|
| 2005 |
Kueltzo LA, Middaugh CR. Polycationic Peptides and Proteins in Drug Delivery: Focus on Nonclassical Transport Drug Delivery: Principles and Applications. 279-304. DOI: 10.1002/0471475734.ch13 |
0.689 |
|
| 2004 |
Wiethoff CM, Koe JG, Koe GS, Middaugh CR. Compositional effects of cationic lipid/DNA delivery systems on transgene expression in cell culture. Journal of Pharmaceutical Sciences. 93: 108-23. PMID 14648641 DOI: 10.1002/Jps.10519 |
0.657 |
|
| 2003 |
Lobo BA, Vetro JA, Suich DM, Zuckermann RN, Middaugh CR. Structure/function analysis of peptoid/lipitoid:DNA complexes. Journal of Pharmaceutical Sciences. 92: 1905-18. PMID 12950008 DOI: 10.1002/Jps.10450 |
0.746 |
|
| 2003 |
Kueltzo LA, Ersoy B, Ralston JP, Middaugh CR. Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: a bGCSF case study. Journal of Pharmaceutical Sciences. 92: 1805-20. PMID 12949999 DOI: 10.1002/Jps.10439 |
0.73 |
|
| 2003 |
Kueltzo LA, Middaugh CR. Structural characterization of bovine granulocyte colony stimulating factor: effect of temperature and pH. Journal of Pharmaceutical Sciences. 92: 1793-804. PMID 12949998 DOI: 10.1002/Jps.10440 |
0.741 |
|
| 2003 |
Kueltzo LA, Middaugh CR. Nonclassical transport proteins and peptides: an alternative to classical macromolecule delivery systems. Journal of Pharmaceutical Sciences. 92: 1754-72. PMID 12949995 DOI: 10.1002/Jps.10448 |
0.726 |
|
| 2003 |
Tiyaboonchai W, Woiszwillo J, Middaugh CR. Formulation and characterization of DNA-polyethylenimine-dextran sulfate nanoparticles. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 19: 191-202. PMID 12885383 DOI: 10.1016/S0928-0987(03)00102-7 |
0.648 |
|
| 2003 |
Choosakoonkriang S, Lobo BA, Koe GS, Koe JG, Middaugh CR. Biophysical characterization of PEI/DNA complexes. Journal of Pharmaceutical Sciences. 92: 1710-22. PMID 12884257 DOI: 10.1002/Jps.10437 |
0.79 |
|
| 2003 |
Lobo BA, Koe GS, Koe JG, Middaugh CR. Thermodynamic analysis of binding and protonation in DOTAP/DOPE (1:1): DNA complexes using isothermal titration calorimetry. Biophysical Chemistry. 104: 67-78. PMID 12834828 DOI: 10.1016/S0301-4622(02)00339-3 |
0.756 |
|
| 2003 |
Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles. Journal of Pharmaceutical Sciences. 92: 1272-85. PMID 12761816 DOI: 10.1002/Jps.10391 |
0.662 |
|
| 2003 |
Tiyaboonchai W, Woiszwillo J, Sims RC, Middaugh CR. Insulin containing polyethylenimine-dextran sulfate nanoparticles. International Journal of Pharmaceutics. 255: 139-51. PMID 12672610 DOI: 10.1016/S0378-5173(03)00055-3 |
0.646 |
|
| 2003 |
Rexroad J, Wiethoff CM, Green AP, Kierstead TD, Scott MO, Middaugh CR. Structural stability of adenovirus type 5. Journal of Pharmaceutical Sciences. 92: 665-78. PMID 12587128 DOI: 10.1002/Jps.10340 |
0.815 |
|
| 2003 |
Braun CS, Jas GS, Choosakoonkriang S, Koe GS, Smith JG, Middaugh CR. The structure of DNA within cationic lipid/DNA complexes. Biophysical Journal. 84: 1114-23. PMID 12547792 DOI: 10.1016/S0006-3495(03)74927-3 |
0.785 |
|
| 2003 |
Brandau DT, Jones LS, Wiethoff CM, Rexroad J, Middaugh CR. Thermal stability of vaccines. Journal of Pharmaceutical Sciences. 92: 218-31. PMID 12532371 DOI: 10.1002/Jps.10296 |
0.782 |
|
| 2003 |
Wiethoff CM, Middaugh CR. Barriers to nonviral gene delivery. Journal of Pharmaceutical Sciences. 92: 203-17. PMID 12532370 DOI: 10.1002/Jps.10286 |
0.639 |
|
| 2003 |
Choosakoonkriang S, Wiethoff CM, Koe GS, Koe JG, Anchordoquy TJ, Middaugh CR. An infrared spectroscopic study of the effect of hydration on cationic lipid/DNA complexes. Journal of Pharmaceutical Sciences. 92: 115-30. PMID 12486688 DOI: 10.1002/Jps.10279 |
0.792 |
|
| 2003 |
Kueltzo LA, Osiecki J, Barker J, Picking WL, Ersoy B, Picking WD, Middaugh CR. Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. The Journal of Biological Chemistry. 278: 2792-8. PMID 12427760 DOI: 10.1074/Jbc.M208383200 |
0.741 |
|
| 2002 |
Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. The structural organization of cationic lipid-DNA complexes. The Journal of Biological Chemistry. 277: 44980-7. PMID 12297507 DOI: 10.1074/Jbc.M207758200 |
0.655 |
|
| 2002 |
Huang CY, Ma SS, Lee S, Radhakrishnan R, Braun CS, Choosakoonkriang S, Wiethoff CM, Lobo BA, Middaugh CR. Enhancements in gene expression by the choice of plasmid DNA formulations containing neutral polymeric excipients. Journal of Pharmaceutical Sciences. 91: 1371-81. PMID 11977113 DOI: 10.1002/Jps.10130 |
0.769 |
|
| 2002 |
Lobo BA, Rogers SA, Choosakoonkriang S, Smith JG, Koe G, Middaugh CR. Differential scanning calorimetric studies of the thermal stability of plasmid DNA complexed with cationic lipids and polymers. Journal of Pharmaceutical Sciences. 91: 454-66. PMID 11835205 DOI: 10.1002/Jps.10025 |
0.789 |
|
| 2002 |
Rexroad J, Wiethoff CM, Jones LS, Middaugh CR. Lyophilization and the thermostability of vaccines Cell Preservation Technology. 1: 91-104. DOI: 10.1089/153834402320882593 |
0.778 |
|
| 2001 |
Edwards KLT, Kueltzo LA, Fisher MT, Middaugh CR. Complex effects of molecular chaperones on the aggregation and refolding of fibroblast growth factor-1 Archives of Biochemistry and Biophysics. 393: 14-21. PMID 11516157 DOI: 10.1006/Abbi.2001.2472 |
0.725 |
|
| 2001 |
Tiyaboonchai W, Woiszwillo J, Middaugh CR. Formulation and characterization of amphotericin B-polyethylenimine-dextran sulfate nanoparticles Journal of Pharmaceutical Sciences. 90: 902-914. PMID 11458338 DOI: 10.1002/Jps.1042 |
0.619 |
|
| 2001 |
Wiethoff CM, Smith JG, Koe GS, Middaugh CR. The potential role of proteoglycans in cationic lipid-mediated gene delivery: Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans Journal of Biological Chemistry. 276: 32806-32813. PMID 11443107 DOI: 10.1074/Jbc.M007940200 |
0.664 |
|
| 2001 |
Lobo BA, Davis A, Koe G, Smith JG, Middaugh CR. Isothermal titration calorimetric analysis of the interaction between cationic lipids and plasmid DNA Archives of Biochemistry and Biophysics. 386: 95-105. PMID 11361005 DOI: 10.1006/Abbi.2000.2196 |
0.762 |
|
| 2001 |
Choosakoonkriang S, Wiethoff CM, Anchordoquy TJ, Koe GS, Smith JG, Middaugh CR. Infrared Spectroscopic Characterization of the Interaction of Cationic Lipids with Plasmid DNA Journal of Biological Chemistry. 276: 8037-8043. PMID 11118456 DOI: 10.1074/Jbc.M010592200 |
0.788 |
|
| 2000 |
Kueltzo LA, Middaugh CR. Potential use of non-classical pathways for the transport of macromolecular drugs Expert Opinion On Investigational Drugs. 9: 2039-2050. PMID 11060791 DOI: 10.1517/13543784.9.9.2039 |
0.702 |
|
| 2000 |
Kueltzo LA, Normand N, O'Hare P, Middaugh CR. Conformational lability of herpesvirus protein VP22 Journal of Biological Chemistry. 275: 33213-33221. PMID 10913125 DOI: 10.1074/Jbc.M002476200 |
0.753 |
|
| 1997 |
Volkin DB, Burke CJ, Marfia KE, Oswald CB, Wolanski B, Middaugh CR. Size and conformational stability of the hepatitis A virus used to prepare VAQTA, a highly purified inactivated vaccine. Journal of Pharmaceutical Sciences. 86: 666-73. PMID 9188048 DOI: 10.1021/js960475h |
0.322 |
|
| 1995 |
Volkin DB, Verticelli AM, Bruner MW, Marfia KE, Tsai PK, Middaugh CR, Sardana MK. Deamidation of polyanion‐stabilized acidic fibroblast growth factor Journal of Pharmaceutical Sciences. 84: 7-11. PMID 7536241 DOI: 10.1002/jps.2600840104 |
0.328 |
|
| 1987 |
Middaugh CR, Litman GW. Atypical glycosylation of an IgG monoclonal cryoimmunoglobulin. The Journal of Biological Chemistry. 262: 3671-3. PMID 3102493 |
0.506 |
|
| 1986 |
Brandau DT, Lawson EQ, Middaugh CR, Litman GW. The effect of interchain disulfide bond cleavage on the cold induced precipitation of cryoimmunoglobulins. Immunological Investigations. 15: 447-62. PMID 3781575 DOI: 10.3109/08820138609054916 |
0.525 |
|
| 1981 |
Litman GW, Scheffel C, Gerber-Jenson B, Litman R, Middaugh CR. Molecular basis for the temperature-dependent insolubility of cryoglobulins. XII. Anomalous mobility of monoclonal cryoimmunoglobulin heavy chains accompanying polyacrylamide gel electrophoresis in sodium dodecyl sulfate. Immunological Communications. 10: 707-18. PMID 6804373 |
0.539 |
|
| 1980 |
Middaugh CR, Lawson EQ, Litman GW, Tisel WA, Mood DA, Rosenberg A. Thermodynamic basis for the abnormal solubility of monoclonal cryoimmunoglobulins. The Journal of Biological Chemistry. 255: 6532-4. PMID 7190147 |
0.516 |
|
| 1980 |
Litman GW, Gerber-Jenson B, Litman R, Middaugh CR, Scheffel C. Molecular basis for the temperature-dependent insolubility of cryoglobulins--IX. Physicochemical characterization of an IgG1, kappa monoclonal cryoimmunoglobulin exhibiting marginal low temperature-dependent insolubility. Molecular Immunology. 17: 337-44. PMID 6777663 DOI: 10.1016/0161-5890(80)90054-1 |
0.478 |
|
| 1979 |
Thomas GJ, Prescott B, Middaugh CR, Litman GW. Raman spectra and conformational structures of Fab mu and (Fc)5 mu fragments of cryoglobulin IgM-kappa McE. Biochimica Et Biophysica Acta. 577: 285-90. PMID 110353 DOI: 10.1016/0005-2795(79)90032-1 |
0.495 |
|
| 1978 |
Middaugh CR, Litman GW. Investigations of the molecular basis for the temperature-dependent insolubility of cryoglobulins. VI. Quenching by acrylamide of the intrinsic tryptophan fluorescence of cryoglobulin and non-cryoglobulin IgM proteins. Biochimica Et Biophysica Acta. 535: 33-43. PMID 667117 DOI: 10.1016/0005-2795(78)90030-2 |
0.539 |
|
| 1978 |
Middaugh CR, Oshman RG, Litman GW. Localization of a conformational anomaly to the Fabmu region of a monoclonal IgM cryoglobulin. Clinical and Experimental Immunology. 31: 126-30. PMID 416930 |
0.538 |
|
| 1978 |
Wang AC, Mathur S, Pandey J, Siegel FP, Middaugh CR, Litman GW. Hv(1), a variable-region genetic marker of human immunoglobulin heavy chains. Science (New York, N.Y.). 200: 327-9. PMID 416494 DOI: 10.1126/Science.416494 |
0.443 |
|
| 1978 |
Middaugh CR, Gerber-Jenson B, Hurvitz A, Paluszek A, Scheffel C, Litman GW. Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. Proceedings of the National Academy of Sciences of the United States of America. 75: 3440-4. PMID 28525 DOI: 10.1073/Pnas.75.7.3440 |
0.579 |
|
| 1978 |
Middaugh CR, Kehoe JM, Prystowsky MB, Gerber-Jenson B, Jenson JC, Litman GW. Molecular basis for the temperature-dependent insolubility of cryoglobulins--IV. Structural studies of the IgM monoclonal cryoglobulin McE. Immunochemistry. 15: 171-87. PMID 25240 DOI: 10.1016/0161-5890(78)90146-3 |
0.55 |
|
| 1977 |
Middaugh CR, Litman GW. Effect of solutes on the cold-induced insolubility of monoclonal cryoimmunoglobulins. The Journal of Biological Chemistry. 252: 8002-6. PMID 914859 |
0.522 |
|
| 1977 |
Middaugh CR, Litman GW. Effect of D2O on the temperature-dependent solubility of cryoglobulin and noncryoglobulin IgM. Febs Letters. 79: 200-2. PMID 891928 DOI: 10.1016/0014-5793(77)80382-7 |
0.468 |
|
| 1977 |
Middaugh CR, Thomas GJ, Prescott B, Aberlin ME, Litman GW. Investigations of the molecular basis for the temperature-dependent insolubility of cryoglobulins. II. Spectroscopic studies of the IgM monoclonal cryoglobulin McE. Biochemistry. 16: 2986-94. PMID 880291 |
0.47 |
|
| 1977 |
Hurvitz AI, MacEwen EG, Middaugh CR, Litman GW. Monoclonal cryoglobulinemia with macroglobulinemia in a dog. Journal of the American Veterinary Medical Association. 170: 511-3. PMID 403167 |
0.426 |
|
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