| Year |
Citation |
Score |
| 2022 |
Liu T, Bowen RL, Wilson AC, Atwood CS. Estropause, Sex Hormones and Metal Homeostasis in the Mouse Brain. Frontiers in Neurology. 13: 841822. PMID 35645980 DOI: 10.3389/fneur.2022.841822 |
0.553 |
|
| 2021 |
Butler T, Goldberg JD, Galvin JE, Maloney T, Ravdin L, Glodzik L, de Leon MJ, Hochman T, Bowen RL, Atwood CS. Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus cholinesterase inhibition to reduce neurologic decline in Alzheimer's. Contemporary Clinical Trials. 106488. PMID 34166841 DOI: 10.1016/j.cct.2021.106488 |
0.591 |
|
| 2019 |
Butler T, Bowen R, Atwood CS. Septal hypertrophy and cell cycle re-entry in AD. Aging. PMID 30668543 DOI: 10.18632/aging.101777 |
0.548 |
|
| 2018 |
Smith MA, Bowen RL, Nguyen RQ, Perry G, Atwood CS, Rimm AA. Putative Gonadotropin Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data. Journal of Alzheimer's Disease : Jad. PMID 29782310 DOI: 10.3233/Jad-170847 |
0.737 |
|
| 2017 |
Atwood CS, Hayashi K, Meethal SV, Gonzales T, Bowen RL. Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species. Geroscience. PMID 28271270 DOI: 10.1007/s11357-016-9955-5 |
0.546 |
|
| 2016 |
Bowen RL, Butler T, Atwood CS. Not All Androgen Deprivation Therapies Are Created Equal: Leuprolide and the Decreased Risk of Developing Alzheimer's Disease. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 27298416 DOI: 10.1200/Jco.2015.66.3997 |
0.619 |
|
| 2015 |
Atwood CS, Bowen RL. A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis. Journal of Alzheimer's Disease : Jad. 47: 33-47. PMID 26402752 DOI: 10.3233/Jad-143210 |
0.665 |
|
| 2015 |
Atwood CS, Bowen RL. The Endocrine Dyscrasia that Accompanies Menopause and Andropause Induces Aberrant Cell Cycle Signaling that Triggers Re-entry of Post-mitotic Neurons into the Cell Cycle, Neurodysfunction, Neurodegeneration and Cognitive Disease. Hormones and Behavior. PMID 26188949 DOI: 10.1016/J.Yhbeh.2015.06.021 |
0.692 |
|
| 2015 |
Bowen RL, Perry G, Xiong C, Smith MA, Atwood CS. A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks. Journal of Alzheimer's Disease : Jad. 44: 549-60. PMID 25310993 DOI: 10.3233/Jad-141626 |
0.659 |
|
| 2012 |
Clark I, Atwood C, Bowen R, Paz-Filho G, Vissel B. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacological Reviews. 64: 1004-26. PMID 22966039 DOI: 10.1124/Pr.112.005850 |
0.605 |
|
| 2011 |
Atwood CS, Bowen RL. The reproductive-cell cycle theory of aging: an update. Experimental Gerontology. 46: 100-7. PMID 20851172 DOI: 10.1016/J.Exger.2010.09.007 |
0.57 |
|
| 2010 |
Gallego MJ, Porayette P, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS. The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes. Stem Cell Research & Therapy. 1: 28. PMID 20836886 DOI: 10.1186/Scrt28 |
0.59 |
|
| 2009 |
Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS. Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. The Journal of Biological Chemistry. 284: 23806-17. PMID 19542221 DOI: 10.1074/Jbc.M109.026328 |
0.593 |
|
| 2009 |
Meethal SV, Liu T, Chan HW, Ginsburg E, Wilson AC, Gray DN, Bowen RL, Vonderhaar BK, Atwood CS. Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent mechanism involving hypothalamic-pituitary-gonadal axis receptors. Journal of Neurochemistry. 110: 1014-27. PMID 19493163 DOI: 10.1111/J.1471-4159.2009.06192.X |
0.627 |
|
| 2009 |
Simon DP, Vadakkadath Meethal S, Wilson AC, Gallego MJ, Weinecke SL, Bruce E, Lyons PF, Haasl RJ, Bowen RL, Atwood CS. Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia (New York, N.Y.). 11: 365-76. PMID 19308291 DOI: 10.1593/Neo.81544 |
0.553 |
|
| 2008 |
Haasl RJ, Ahmadi MR, Meethal SV, Gleason CE, Johnson SC, Asthana S, Bowen RL, Atwood CS. A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele. Bmc Medical Genetics. 9: 37. PMID 18439297 DOI: 10.1186/1471-2350-9-37 |
0.623 |
|
| 2008 |
Casadesus G, Rolston RK, Webber KM, Atwood CS, Bowen RL, Perry G, Smith MA. Menopause, estrogen, and gonadotropins in Alzheimer's disease. Advances in Clinical Chemistry. 45: 139-53. PMID 18429496 DOI: 10.1016/S0065-2423(07)00006-6 |
0.757 |
|
| 2008 |
Wilson AC, Clemente L, Liu T, Bowen RL, Meethal SV, Atwood CS. Reproductive hormones regulate the selective permeability of the blood-brain barrier. Biochimica Et Biophysica Acta. 1782: 401-7. PMID 18381207 DOI: 10.1016/J.Bbadis.2008.02.011 |
0.63 |
|
| 2008 |
Atwood CS, Bowen RL. A multi-hit endocrine model of intrinsic adult-onset asthma. Ageing Research Reviews. 7: 114-25. PMID 18373959 DOI: 10.1016/J.Arr.2007.12.002 |
0.529 |
|
| 2008 |
Gallego MJ, Porayette P, Kaltcheva MM, Bowen RL, Meethal SV, Atwood CS. Trophoblastic hormones direct early human embryogenesis Nature Precedings. DOI: 10.1038/Npre.2008.2671.1 |
0.587 |
|
| 2008 |
Meethal SV, Chan H, Ginsburg E, Wilson AC, Bowen RL, Vonderhaar BK, Atwood CS. P4-220: Identification of a negative feedback loop in the brain for the regulation of neurosteroid synthesis: Implications for Alzheimer's disease Alzheimer's & Dementia. 4: T735-T736. DOI: 10.1016/J.Jalz.2008.05.2288 |
0.618 |
|
| 2008 |
Meethal SV, Ockuly JC, Porayette P, Gallego MJ, Haworth RA, Bowen RL, Atwood CS. P3-390: Gonadotropin-releasing hormone signaling in the aging brain: A recapitulation of its role in embryogenesis and its implications for Alzheimer's disease Alzheimer's & Dementia. 4: T635-T636. DOI: 10.1016/J.Jalz.2008.05.1960 |
0.664 |
|
| 2008 |
Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Meethal SV, Atwood CS. P3-388: Differential processing of amyloid-β precursor protein directs the proliferation and neuronal differentiation of human embryonic stem cells Alzheimer's & Dementia. 4: T635-T635. DOI: 10.1016/J.Jalz.2008.05.1958 |
0.558 |
|
| 2007 |
Webber KM, Casadesus G, Bowen RL, Perry G, Smith MA. Evidence for the role of luteinizing hormone in Alzheimer disease. Endocrine, Metabolic & Immune Disorders Drug Targets. 7: 300-3. PMID 18220951 DOI: 10.2174/187153007782794326 |
0.686 |
|
| 2007 |
Wilson AC, Meethal SV, Bowen RL, Atwood CS. Leuprolide acetate: a drug of diverse clinical applications. Expert Opinion On Investigational Drugs. 16: 1851-63. PMID 17970643 DOI: 10.1517/13543784.16.11.1851 |
0.66 |
|
| 2007 |
Casadesus G, Milliken EL, Webber KM, Bowen RL, Lei Z, Rao CV, Perry G, Keri RA, Smith MA. Increases in luteinizing hormone are associated with declines in cognitive performance. Molecular and Cellular Endocrinology. 269: 107-11. PMID 17376589 DOI: 10.1016/J.Mce.2006.06.013 |
0.612 |
|
| 2007 |
Liu T, Wimalasena J, Bowen RL, Atwood CS. Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression. Journal of Neurochemistry. 100: 1329-39. PMID 17241129 DOI: 10.1111/J.1471-4159.2006.04307.X |
0.636 |
|
| 2007 |
Atwood CS, Bowen RL. Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changes. Medical Hypotheses. 68: 735-49. PMID 17095167 DOI: 10.1016/J.Mehy.2006.08.037 |
0.568 |
|
| 2007 |
Webber KM, Casadesus G, Atwood CS, Bowen RL, Perry G, Smith MA. Gonadotropins: a cohesive gender-based etiology of Alzheimer disease. Molecular and Cellular Endocrinology. 260: 271-5. PMID 17052835 DOI: 10.1016/J.Mce.2006.01.018 |
0.765 |
|
| 2006 |
Wilson AC, Salamat MS, Haasl RJ, Roche KM, Karande A, Meethal SV, Terasawa E, Bowen RL, Atwood CS. Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression. The Journal of Endocrinology. 191: 651-63. PMID 17170222 DOI: 10.1677/Joe.1.07047 |
0.626 |
|
| 2006 |
Casadesus G, Puig ER, Webber KM, Atwood CS, Escuer MC, Bowen RL, Perry G, Smith MA. Targeting gonadotropins: an alternative option for Alzheimer disease treatment. Journal of Biomedicine & Biotechnology. 2006: 39508. PMID 17047306 DOI: 10.1155/Jbb/2006/39508 |
0.754 |
|
| 2006 |
Webber KM, Stocco DM, Casadesus G, Bowen RL, Atwood CS, Previll LA, Harris PL, Zhu X, Perry G, Smith MA. Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Molecular Neurodegeneration. 1: 14. PMID 17018137 DOI: 10.1186/1750-1326-1-14 |
0.745 |
|
| 2006 |
Casadesus G, Garrett MR, Webber KM, Hartzler AW, Atwood CS, Perry G, Bowen RL, Smith MA. The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease. Drugs in R&D. 7: 187-93. PMID 16752944 DOI: 10.2165/00126839-200607030-00004 |
0.771 |
|
| 2006 |
Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA. Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. Biochimica Et Biophysica Acta. 1762: 447-52. PMID 16503402 DOI: 10.1016/J.Bbadis.2006.01.008 |
0.742 |
|
| 2006 |
Webber KM, Casadesus G, Zhu X, Obrenovich ME, Atwood CS, Perry G, Bowen RL, Smith MA. The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target. Current Pharmaceutical Design. 12: 691-7. PMID 16472159 DOI: 10.2174/138161206775474305 |
0.741 |
|
| 2006 |
Gregory CW, Atwood CS, Smith MA, Bowen RL. Antigonadotropins: a novel strategy to halt Alzheimer's disease progression. Current Pharmaceutical Design. 12: 685-90. PMID 16472158 DOI: 10.2174/138161206775474288 |
0.731 |
|
| 2006 |
Wilson AC, Salamat MS, Meethal SV, Smith MA, Terasawa E, Bowen RL, Atwood CS. Extrapituitary expression of luteinizing hormone by human neurons possessing GnRH receptor 1 Frontiers in Neuroendocrinology. 27: 87-88. DOI: 10.1016/J.Yfrne.2006.03.190 |
0.649 |
|
| 2006 |
Meethal SV, Gallego MJ, Haasl RJ, Petras SJ, Sgro JY, Bowen RL, Atwood CS. Identification of a gonadotropin-releasing hormone receptor homologue in Caenorhabditis elegans Frontiers in Neuroendocrinology. 27: 71. DOI: 10.1016/J.Yfrne.2006.03.149 |
0.589 |
|
| 2006 |
Webber KM, Casadesus G, Previll LA, Zhu X, Gregory C, Bowen R, Atwood CS, Perry G, Stocco DM, Smith MA. P1-369: Evidence of gonadotropin-induced steroidogenesis in Alzheimer's disease Alzheimer's & Dementia. 2: S206-S206. DOI: 10.1016/J.Jalz.2006.05.747 |
0.703 |
|
| 2006 |
Casadesus G, Webber KM, Atwood CS, Bowen RL, Perry G, Smith MA. P3-296: Luteinizing hormone mediates Alzheimer-type changes in neurons Alzheimer's & Dementia. 2: S462-S462. DOI: 10.1016/J.Jalz.2006.05.1565 |
0.702 |
|
| 2005 |
Meethal SV, Smith MA, Bowen RL, Atwood CS. The gonadotropin connection in Alzheimer's disease. Endocrine. 26: 317-26. PMID 16034187 DOI: 10.1385/Endo:26:3:317 |
0.752 |
|
| 2005 |
Webber KM, Casadesus G, Marlatt MW, Perry G, Hamlin CR, Atwood CS, Bowen RL, Smith MA. Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis. Annals of the New York Academy of Sciences. 1052: 201-9. PMID 16024763 DOI: 10.1196/Annals.1347.020 |
0.757 |
|
| 2005 |
Ashford JW, Atwood CS, Blass JP, Bowen RL, Finch CE, Iqbal K, Joseph JA, Perry G. What is aging? What is its role in Alzheimer's disease? What can we do about it? Journal of Alzheimer's Disease : Jad. 7: 247-53; discussion 2. PMID 16006669 DOI: 10.3233/Jad-2005-7308 |
0.649 |
|
| 2005 |
Webber KM, Casadesus G, Perry G, Atwood CS, Bowen R, Smith MA. Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis. Alzheimer Disease and Associated Disorders. 19: 95-9. PMID 15942328 DOI: 10.1097/01.Wad.0000165512.90864.3F |
0.759 |
|
| 2005 |
Atwood CS, Meethal SV, Liu T, Wilson AC, Gallego M, Smith MA, Bowen RL. Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. Journal of Neuropathology and Experimental Neurology. 64: 93-103. PMID 15751223 DOI: 10.1093/Jnen/64.2.93 |
0.738 |
|
| 2005 |
Atwood CS, Smith MA, Bowen RL. Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis. Journal of Alzheimer's Disease : Jad. 7: 1-2. PMID 15750209 DOI: 10.3233/Jad-2005-7101 |
0.696 |
|
| 2005 |
Gregory CW, Bowen RL. Novel therapeutic strategies for Alzheimer's disease based on the forgotten reproductive hormones. Cellular and Molecular Life Sciences : Cmls. 62: 313-9. PMID 15723167 DOI: 10.1007/s00018-004-4386-y |
0.451 |
|
| 2005 |
Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen RL, Smith MA. Evidence for the role of gonadotropin hormones in the development of Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 62: 293-8. PMID 15723165 DOI: 10.1007/S00018-004-4384-0 |
0.767 |
|
| 2005 |
Bowen RL, Martins RN, Gregory CW, Smith MA, Atwood CS. Dementia and testosterone levels in men. Jama. 293: 551; author reply 55. PMID 15687304 DOI: 10.1001/Jama.293.5.551-B |
0.61 |
|
| 2004 |
Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA. Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease. Current Drug Targets. Cns and Neurological Disorders. 3: 281-5. PMID 15379604 DOI: 10.2174/1568007043337265 |
0.783 |
|
| 2004 |
Bowen RL, Atwood CS. Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones. Gerontology. 50: 265-90. PMID 15331856 DOI: 10.1159/000079125 |
0.603 |
|
| 2004 |
Bowen RL, Gregory CW. Sex hormones and ApoE4: beyond steroids. Journal of Alzheimer's Disease : Jad. 6: 229-30. PMID 15252936 DOI: 10.3233/Jad-2004-6303 |
0.452 |
|
| 2004 |
Webber KM, Bowen R, Casadesus G, Perry G, Atwood CS, Smith MA. Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection. Acta Neurobiologiae Experimentalis. 64: 113-8. PMID 15190686 |
0.748 |
|
| 2004 |
Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. Journal of Neuroscience Research. 75: 698-703. PMID 14991845 DOI: 10.1002/Jnr.20028 |
0.71 |
|
| 2004 |
Bowen RL, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS. Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. The Journal of Biological Chemistry. 279: 20539-45. PMID 14871891 DOI: 10.1074/Jbc.M311993200 |
0.728 |
|
| 2004 |
Casadesus G, Webber KM, Ogawa O, Bowen RL, Atwood CS, Perry G, Smith MA. P1-369 Modulation of cognition and amyloid load in the aged SWAβPP transgenic mouse by luprolide acetate, a GNRH agonist: targeting luteinizing hormone as a novel treatment for AD Neurobiology of Aging. 25: S203. DOI: 10.1016/S0197-4580(04)80681-X |
0.71 |
|
| 2004 |
Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk J, Shah S, Atwood CS, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. O2-04-07 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1 associated regulator of cyclin B, in Alzheimer disease Neurobiology of Aging. 25: S40. DOI: 10.1016/S0197-4580(04)80133-7 |
0.678 |
|
| 2004 |
Atwood CS, Liu T, Smith MA, Martins RN, Bowen RL, Verdile G. O2-04-06 17β-Estradiol and luteinizing hormone modulate the expression of luteinizing hormone receptors in neuroblastoma cells Neurobiology of Aging. 25: S40. DOI: 10.1016/S0197-4580(04)80132-5 |
0.643 |
|
| 2004 |
Bowen R, Atwood CS, Perry G, Smith MA. Mechanisms Involved in Gender Differences in Alzheimer's Disease: The Role of Leuteinizing and Follicle Stimulating Hormones Principles of Gender-Specific Medicine. 2: 1234-1237. DOI: 10.1016/B978-012440905-7/50388-1 |
0.725 |
|
| 2003 |
Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R. Pennington scientific symposium on mechanisms and retardation of aging. Experimental Gerontology. 38: 1217-26. PMID 14580876 DOI: 10.1016/J.Exger.2003.08.005 |
0.538 |
|
| 2003 |
Atwood CS, Bowen RL, Smith MA, Perry G. Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply. Brain Research. Brain Research Reviews. 43: 164-78. PMID 14499467 DOI: 10.1016/S0165-0173(03)00206-6 |
0.642 |
|
| 2003 |
Smith MA, Perry G, Atwood CS, Bowen RL. Estrogen replacement and risk of Alzheimer disease. Jama. 289: 1100; author reply 1. PMID 12622570 DOI: 10.1001/Jama.289.9.1100-A |
0.707 |
|
| 2002 |
Bowen RL, Smith MA, Harris PL, Kubat Z, Martins RN, Castellani RJ, Perry G, Atwood CS. Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology. Journal of Neuroscience Research. 70: 514-8. PMID 12391612 DOI: 10.1002/Jnr.10452 |
0.758 |
|
| 2001 |
Short RA, Bowen RL, O'Brien PC, Graff-Radford NR. Elevated gonadotropin levels in patients with Alzheimer disease. Mayo Clinic Proceedings. 76: 906-9. PMID 11560301 DOI: 10.4065/76.9.906 |
0.32 |
|
| 2001 |
Bowen RL. Sex hormones, amyloid protein, and Alzheimer disease. Jama. 286: 790-1. PMID 11497529 DOI: 10.1001/Jama.286.7.790 |
0.508 |
|
| 2000 |
Bowen RL, Isley JP, Atkinson RL. An association of elevated serum gonadotropin concentrations and Alzheimer disease? Journal of Neuroendocrinology. 12: 351-4. PMID 10718932 DOI: 10.1046/j.1365-2826.2000.00461.x |
0.396 |
|
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