Natalia L. Komarova - Publications

Affiliations: 
Mathematics - Ph.D. University of California, Irvine, Irvine, CA 
Area:
Applied Mathematics, Oncology

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wodarz D, Komarova NL. Mutant Evolution in Spatially Structured and Fragmented Expanding Populations. Genetics. PMID 32661138 DOI: 10.1534/Genetics.120.303422  0.34
2020 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Beyond the pair approximation: Modeling colonization population dynamics. Physical Review. E. 101: 032404. PMID 32289892 DOI: 10.1103/Physreve.101.032404  0.306
2020 Komarova NL, Boland CR, Goel A, Wodarz D. Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. e1487. PMID 32163237 DOI: 10.1002/Wsbm.1487  0.342
2020 Shimura T, Toden S, Komarova NL, Boland C, Wodarz D, Goel A. A comprehensive in vivo and mathematic modeling-based kinetic characterization for aspirin-induced chemoprevention in colorectal cancer. Carcinogenesis. PMID 31904094 DOI: 10.1093/Carcin/Bgz195  0.329
2019 Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth D, Jarrett AM, Lima EABDF, Oden J, Biros G, Yankeelov TE, Curtius K, Bakir IA, Wodarz D, ... Komarova N, et al. The 2019 Mathematical Oncology Roadmap. Physical Biology. PMID 30991381 DOI: 10.1088/1478-3975/Ab1A09  0.303
2018 Rodriguez-Brenes IA, Komarova NL, Wodarz D. The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach. Journal of Theoretical Biology. 460: 144-152. PMID 30315815 DOI: 10.1016/J.Jtbi.2018.09.003  0.353
2018 Wodarz D, Newell AC, Komarova NL. Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution. Journal of the Royal Society, Interface. 15. PMID 29875280 DOI: 10.1098/Rsif.2017.0967  0.362
2018 Harris D, Wodarz D, Komarova NL. Spatial evolution of regularization in learned behavior of animals. Mathematical Biosciences. PMID 29550299 DOI: 10.1016/J.Mbs.2018.03.005  0.301
2018 Alvarado C, Fider NA, Wearing HJ, Komarova NL. Optimizing homeostatic cell renewal in hierarchical tissues. Plos Computational Biology. 14: e1005967. PMID 29447149 DOI: 10.1371/Journal.Pcbi.1005967  0.351
2017 Farhang-Sardroodi S, Darooneh AH, Nikbakht M, Komarova NL, Kohandel M. The effect of spatial randomness on the average fixation time of mutants. Plos Computational Biology. 13: e1005864. PMID 29176825 DOI: 10.1371/Journal.Pcbi.1005864  0.307
2017 Wodarz D, Goel A, Komarova NL. Effect of cell cycle duration on somatic evolutionary dynamics. Evolutionary Applications. 10: 1121-1129. PMID 29151865 DOI: 10.1111/Eva.12518  0.329
2017 Wodarz D, Goel A, Boland CR, Komarova NL. Effect of aspirin on tumour cell colony formation and evolution. Journal of the Royal Society, Interface. 14. PMID 28878032 DOI: 10.1098/Rsif.2017.0374  0.34
2017 Mahdipour-Shirayeh A, Darooneh AH, Long AD, Komarova NL, Kohandel M. Genotype by random environmental interactions gives an advantage to non-favored minor alleles. Scientific Reports. 7: 5193. PMID 28701726 DOI: 10.1038/S41598-017-05375-0  0.379
2017 Zhang J, Fleischman A, Wodarz D, Komarova NL. Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms. Journal of Theoretical Biology. PMID 28501635 DOI: 10.1016/J.Jtbi.2017.05.012  0.355
2017 Ma T, Komarova NL. Mathematical Modeling of Learning from an Inconsistent Source: A Nonlinear Approach. Bulletin of Mathematical Biology. PMID 28194620 DOI: 10.1007/S11538-017-0250-0  0.304
2017 Zumwalt TJ, Wodarz D, Komarova NL, Toden S, Turner J, Cardenas J, Burn J, Chan AT, Boland CR, Goel A. Aspirin-induced chemoprevention and response kinetics are enhanced by PIK3CA mutations in colorectal cancer cells. Cancer Prevention Research (Philadelphia, Pa.). PMID 28154202 DOI: 10.1158/1940-6207.Capr-16-0175  0.35
2017 Weiss LD, Komarova NL, Rodriguez-Brenes IA. Mathematical Modeling of Normal and Cancer Stem Cells Current Stem Cell Reports. 3: 232-239. DOI: 10.1007/S40778-017-0094-4  0.33
2016 Shahriyari L, Komarova NL, Jilkine A. The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts. Biology Direct. 11: 42. PMID 27549762 DOI: 10.1186/S13062-016-0141-6  0.326
2016 Sun Z, Plikus MV, Komarova NL. Near Equilibrium Calculus of Stem Cells in Application to the Airway Epithelium Lineage. Plos Computational Biology. 12: e1004990. PMID 27427948 DOI: 10.1371/Journal.Pcbi.1004990  0.319
2016 Asatryan AD, Komarova NL. Evolution of genetic instability in heterogeneous tumors. Journal of Theoretical Biology. 396: 1-12. PMID 26826489 DOI: 10.1016/J.Jtbi.2015.11.028  0.383
2016 Rische JL, Komarova NL. Regularization of languages by adults and children: A mathematical framework. Cognitive Psychology. 84: 1-30. PMID 26580218 DOI: 10.1016/J.Cogpsych.2015.10.001  0.676
2016 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Cellular replication limits in the Luria–Delbrück mutation model Physica D: Nonlinear Phenomena. 328: 44-51. DOI: 10.1016/J.Physd.2016.04.007  0.397
2015 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy. Scientific Reports. 5: 17660. PMID 26647820 DOI: 10.1038/Srep17660  0.351
2015 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Characterizing inhibited tumor growth in stem-cell-driven non-spatial cancers. Mathematical Biosciences. 270: 135-41. PMID 26344137 DOI: 10.1016/J.Mbs.2015.08.009  0.324
2015 Komarova NL. Cancer: A moving target. Nature. 525: 198-9. PMID 26308890 DOI: 10.1038/Nature15210  0.342
2015 Shahriyari L, Komarova NL. The role of the bi-compartmental stem cell niche in delaying cancer. Physical Biology. 12: 055001. PMID 26228740 DOI: 10.1088/1478-3975/12/5/055001  0.342
2015 Yang J, Sun Z, Komarova NL. Analysis of stochastic stem cell models with control. Mathematical Biosciences. 266: 93-107. PMID 26073965 DOI: 10.1016/J.Mbs.2015.06.001  0.31
2015 Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland CR, Goel A. Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 36: 355-67. PMID 25653233 DOI: 10.1093/Carcin/Bgv006  0.331
2014 Komarova NL, Burger JA, Wodarz D. Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL). Proceedings of the National Academy of Sciences of the United States of America. 111: 13906-11. PMID 25201956 DOI: 10.1073/Pnas.1409362111  0.346
2014 Wodarz D, Chan CN, Trinité B, Komarova NL, Levy DN. On the laws of virus spread through cell populations. Journal of Virology. 88: 13240-8. PMID 25187551 DOI: 10.1128/Jvi.02096-14  0.323
2014 Mandelshtam Y, Komarova NL. When learners surpass their models: mathematical modeling of learning from an inconsistent source. Bulletin of Mathematical Biology. 76: 2198-216. PMID 25124767 DOI: 10.1007/S11538-014-9990-2  0.304
2014 Komarova NL. Spatial interactions and cooperation can change the speed of evolution of complex phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 111: 10789-95. PMID 25024187 DOI: 10.1073/Pnas.1400828111  0.324
2014 Komarova NL, Shahriyari L, Wodarz D. Complex role of space in the crossing of fitness valleys by asexual populations. Journal of the Royal Society, Interface / the Royal Society. 11: 20140014. PMID 24671934 DOI: 10.1098/Rsif.2014.0014  0.318
2014 Manem VS, Kohandel M, Komarova NL, Sivaloganathan S. Spatial invasion dynamics on random and unstructured meshes: implications for heterogeneous tumor populations. Journal of Theoretical Biology. 349: 66-73. PMID 24462897 DOI: 10.1016/J.Jtbi.2014.01.009  0.335
2014 Rodriguez-Brenes IA, Komarova NL, Wodarz D. Cancer-associated mutations in healthy individuals: assessing the risk of carcinogenesis. Cancer Research. 74: 1661-9. PMID 24453004 DOI: 10.1158/0008-5472.Can-13-1452  0.385
2014 Jackson T, Komarova N, Swanson K. Mathematical oncology: Using mathematics to enable cancer discoveries American Mathematical Monthly. 121: 840-856. DOI: 10.4169/Amer.Math.Monthly.121.09.840  0.329
2013 Shahriyari L, Komarova NL. Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer? Plos One. 8: e76195. PMID 24204602 DOI: 10.1371/Journal.Pone.0076195  0.341
2013 Komarova NL. Spatial stochastic models of cancer: fitness, migration, invasion. Mathematical Biosciences and Engineering : Mbe. 10: 761-75. PMID 23906148 DOI: 10.3934/Mbe.2013.10.761  0.355
2013 Komarova NL, Boland CR. Cancer: calculated treatment. Nature. 499: 291-2. PMID 23868257 DOI: 10.1038/499291A  0.363
2013 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Minimizing the risk of cancer: tissue architecture and cellular replication limits. Journal of the Royal Society, Interface / the Royal Society. 10: 20130410. PMID 23825115 DOI: 10.1098/Rsif.2013.0410  0.332
2013 Rodriguez-Brenes IA, Wodarz D, Komarova NL. Stem cell control, oscillations, and tissue regeneration in spatial and non-spatial models. Frontiers in Oncology. 3: 82. PMID 23596567 DOI: 10.3389/Fonc.2013.00082  0.304
2012 Komarova NL, Urwin E, Wodarz D. Accelerated crossing of fitness valleys through division of labor and cheating in asexual populations. Scientific Reports. 2: 917. PMID 23209877 DOI: 10.1038/Srep00917  0.759
2012 Sorace R, Komarova NL. Accumulation of neutral mutations in growing cell colonies with competition. Journal of Theoretical Biology. 314: 84-94. PMID 22940236 DOI: 10.1016/J.Jtbi.2012.08.015  0.371
2012 Wodarz D, Hofacre A, Lau JW, Sun Z, Fan H, Komarova NL. Complex spatial dynamics of oncolytic viruses in vitro: mathematical and experimental approaches. Plos Computational Biology. 8: e1002547. PMID 22719239 DOI: 10.1371/Journal.Pcbi.1002547  0.318
2011 Rodriguez-Brenes IA, Komarova NL, Wodarz D. Evolutionary dynamics of feedback escape and the development of stem-cell-driven cancers. Proceedings of the National Academy of Sciences of the United States of America. 108: 18983-8. PMID 22084071 DOI: 10.1073/Pnas.1107621108  0.333
2011 Komarova NL. Mathematical modeling of cyclic treatments of chronic myeloid leukemia. Mathematical Biosciences and Engineering : Mbe. 8: 289-306. PMID 21631131 DOI: 10.3934/Mbe.2011.8.289  0.455
2011 Katouli AA, Komarova NL. The worst drug rule revisited: mathematical modeling of cyclic cancer treatments. Bulletin of Mathematical Biology. 73: 549-84. PMID 20396972 DOI: 10.1007/S11538-010-9539-Y  0.733
2010 Katouli AA, Komarova NL. Optimizing combination therapies with existing and future CML drugs. Plos One. 5: e12300. PMID 20808800 DOI: 10.1371/Journal.Pone.0012300  0.733
2010 Thalhauser CJ, Lowengrub JS, Stupack D, Komarova NL. Selection in spatial stochastic models of cancer: migration as a key modulator of fitness. Biology Direct. 5: 21. PMID 20406439 DOI: 10.1186/1745-6150-5-21  0.311
2010 Komarova NL, Wodarz D. ODE models for oncolytic virus dynamics. Journal of Theoretical Biology. 263: 530-43. PMID 20085772 DOI: 10.1016/J.Jtbi.2010.01.009  0.326
2010 Wan FYM, Sadovsky AV, Komarova NL. Genetic Instability in Cancer: An Optimal Control Problem Studies in Applied Mathematics. 125: 1-38. DOI: 10.1111/J.1467-9590.2009.00476.X  0.358
2009 Komarova NL, Wodarz D. Combination therapies against chronic myeloid leukemia: short-term versus long-term strategies. Cancer Research. 69: 4904-10. PMID 19458080 DOI: 10.1158/0008-5472.Can-08-1959  0.426
2009 Komarova NL, Katouli AA, Wodarz D. Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia. Plos One. 4: e4423. PMID 19204794 DOI: 10.1371/Journal.Pone.0004423  0.726
2009 Wodarz D, Komarova N. Towards predictive computational models of oncolytic virus therapy: basis for experimental validation and model selection. Plos One. 4: e4271. PMID 19180240 DOI: 10.1371/Journal.Pone.0004271  0.344
2008 Komarova NL, Sadovsky AV, Wan FY. Selective pressures for and against genetic instability in cancer: a time-dependent problem. Journal of the Royal Society, Interface / the Royal Society. 5: 105-21. PMID 17580291 DOI: 10.1098/Rsif.2007.1054  0.352
2007 Komarova NL, Wodarz D. Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancer. Theoretical Population Biology. 72: 523-38. PMID 17915274 DOI: 10.1016/J.Tpb.2007.08.003  0.422
2007 Komarova NL, Wu L, Baldi P. The fixed-size Luria-Delbruck model with a nonzero death rate. Mathematical Biosciences. 210: 253-90. PMID 17583754 DOI: 10.1016/J.Mbs.2007.04.007  0.325
2007 Wodarz D, Komarova N. Can loss of apoptosis protect against cancer? Trends in Genetics : Tig. 23: 232-7. PMID 17382429 DOI: 10.1016/J.Tig.2007.03.005  0.317
2007 KOMAROVA NL. STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER Mathematical Models and Methods in Applied Sciences. 17: 1647-1673. DOI: 10.1142/S021820250700242X  0.385
2006 Komarova NL. Spatial stochastic models for cancer initiation and progression. Bulletin of Mathematical Biology. 68: 1573-99. PMID 16832734 DOI: 10.1007/S11538-005-9046-8  0.327
2006 Komarova NL, Cheng P. Epithelial tissue architecture protects against cancer. Mathematical Biosciences. 200: 90-117. PMID 16427657 DOI: 10.1016/J.Mbs.2005.12.001  0.373
2006 Komarova N. Stochastic modeling of drug resistance in cancer. Journal of Theoretical Biology. 239: 351-66. PMID 16194548 DOI: 10.1016/J.Jtbi.2005.08.003  0.447
2006 Komarova NL. Loss- and Gain-of-Function Mutations in Cancer: Mass-action, Spatial and Hierarchical Models Journal of Statistical Physics. 128: 413-446. DOI: 10.1007/S10955-006-9238-0  0.362
2005 Wodarz D, Komarova NL. Emergence and prevention of resistance against small molecule inhibitors. Seminars in Cancer Biology. 15: 506-14. PMID 16154360 DOI: 10.1016/J.Semcancer.2005.07.002  0.422
2005 Komarova NL. Cancer, aging and the optimal tissue design. Seminars in Cancer Biology. 15: 494-505. PMID 16143543 DOI: 10.1016/J.Semcancer.2005.07.003  0.341
2005 Komarova NL, Wodarz D. Drug resistance in cancer: principles of emergence and prevention. Proceedings of the National Academy of Sciences of the United States of America. 102: 9714-9. PMID 15980154 DOI: 10.1073/Pnas.0501870102  0.434
2005 Iwasa Y, Michor F, Komarova NL, Nowak MA. Population genetics of tumor suppressor genes. Journal of Theoretical Biology. 233: 15-23. PMID 15615616 DOI: 10.1016/J.Jtbi.2004.09.001  0.346
2005 Komarova NL. Mathematical modeling of tumorigenesis: mission possible. Current Opinion in Oncology. 17: 39-43. PMID 15608511 DOI: 10.1097/01.Cco.0000143681.37692.32  0.308
2004 Komarova NL, Wang L. Initiation of colorectal cancer: where do the two hits hit? Cell Cycle (Georgetown, Tex.). 3: 1558-65. PMID 15611641 DOI: 10.4161/Cc.3.12.1186  0.351
2004 Komarova NL. Replicator-mutator equation, universality property and population dynamics of learning. Journal of Theoretical Biology. 230: 227-39. PMID 15302554 DOI: 10.1016/J.Jtbi.2004.05.004  0.309
2004 Nowak MA, Michor F, Komarova NL, Iwasa Y. Evolutionary dynamics of tumor suppressor gene inactivation. Proceedings of the National Academy of Sciences of the United States of America. 101: 10635-8. PMID 15252197 DOI: 10.1073/Pnas.0400747101  0.338
2004 Komarova NL, Wodarz D. The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer. Proceedings of the National Academy of Sciences of the United States of America. 101: 7017-21. PMID 15105448 DOI: 10.1073/Pnas.0401943101  0.342
2004 Komarova N. Does Cancer Solve an Optimization Problem? Cell Cycle. 3: 838-842. DOI: 10.4161/Cc.3.7.974  0.319
2003 Komarova NL, Sengupta A, Nowak MA. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. Journal of Theoretical Biology. 223: 433-50. PMID 12875822 DOI: 10.1016/S0022-5193(03)00120-6  0.368
2003 Michor F, Iwasa Y, Komarova NL, Nowak MA. Local regulation of homeostasis favors chromosomal instability. Current Biology : Cb. 13: 581-4. PMID 12676089 DOI: 10.1016/S0960-9822(03)00172-6  0.353
2003 Komarova NL, Barnes E, Klenerman P, Wodarz D. Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success. Proceedings of the National Academy of Sciences of the United States of America. 100: 1855-60. PMID 12574516 DOI: 10.1073/Pnas.0337483100  0.304
2002 Komarova NL, Lengauer C, Vogelstein B, Nowak MA. Dynamics of genetic instability in sporadic and familial colorectal cancer. Cancer Biology & Therapy. 1: 685-92. PMID 12642695 DOI: 10.4161/Cbt.321  0.314
2001 Komarova NL, Niyogi P, Nowak MA. The evolutionary dynamics of grammar acquisition. Journal of Theoretical Biology. 209: 43-59. PMID 11237569 DOI: 10.1006/Jtbi.2000.2240  0.301
2001 Nowak MA, Komarova NL, Niyogi P. Evolution of universal grammar. Science (New York, N.Y.). 291: 114-8. PMID 11141560 DOI: 10.1126/Science.291.5501.114  0.305
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