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Rakesh K. Jain - Publications

Affiliations: 
1976-1983 Chemical and Biomedical Engineering Columbia University, New York, NY 
 1983-1991 Chemical and Biomedical Engineering Carnegie Mellon University, Pittsburgh, PA 
 1991- Engineering and Applied Sciences Harvard Medical School, Boston, MA, United States 
Area:
Biomedical Engineering
Website:
https://steelelabs.mgh.harvard.edu/rakesh_jain#pi_bio
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Year Citation  Score
2024 Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, ... ... Jain RK, et al. Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321336121. PMID 38530888 DOI: 10.1073/pnas.2321336121  0.673
2024 Datta M, Kennedy M, Siri S, Via LE, Baish JW, Xu L, Dartois V, Barry CE, Jain RK. Mathematical model of oxygen, nutrient, and drug transport in Tuberculosis Granulomas. Plos Computational Biology. 20: e1011847. PMID 38335224 DOI: 10.1371/journal.pcbi.1011847  0.76
2024 Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, ... ... Jain RK, et al. Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer Immunology Research. PMID 38260999 DOI: 10.1158/2326-6066.CIR-23-0486  0.679
2023 Jain R, Krishnan S, Lee S, Amoozgar Z, Subudhi S, Kumar A, Posada J, Lindeman N, Lei P, Duquette M, Roberge S, Huang P, Andersson P, Datta M, Munn L, et al. Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Research Square. PMID 38234841 DOI: 10.21203/rs.3.rs-3707472/v1  0.686
2023 Iorgulescu JB, Ruthen N, Ahn R, Panagioti E, Gokhale PC, Neagu M, Speranza MC, Eschle BK, Soroko KM, Piranlioglu R, Datta M, Krishnan S, Yates KB, Baker GJ, Jain RK, et al. Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Frontiers in Immunology. 14: 1297932. PMID 38213329 DOI: 10.3389/fimmu.2023.1297932  0.697
2023 Dong X, Ren J, Amoozgar Z, Lee S, Datta M, Roberge S, Duquette M, Fukumura D, Jain RK. Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice. Journal For Immunotherapy of Cancer. 11. PMID 36898734 DOI: 10.1136/jitc-2022-005583  0.716
2023 Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, ... ... Jain RK, et al. Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Biorxiv : the Preprint Server For Biology. PMID 36747853 DOI: 10.1101/2023.01.26.525680  0.684
2023 Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, ... ... Jain RK, et al. Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219199120. PMID 36724255 DOI: 10.1073/pnas.2219199120  0.795
2022 Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK. Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35584239 DOI: 10.1158/1078-0432.CCR-22-0486  0.634
2022 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Jain RK, et al. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer. 2: 1243. PMID 35122065 DOI: 10.1038/s43018-021-00283-9  0.603
2021 Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, ... ... Jain RK, et al. Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34725151 DOI: 10.1073/pnas.2105323118  0.779
2021 Wu L, Vasilijic S, Sun Y, Chen J, Landegger LD, Zhang Y, Zhou W, Ren J, Early S, Yin Z, Ho WW, Zhang N, Gao X, Lee GY, Datta M, ... ... Jain RK, et al. Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models. Science Translational Medicine. 13. PMID 34261799 DOI: 10.1126/scitranslmed.abd4816  0.682
2021 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Jain RK, et al. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nature Cancer. 2: 414-428. PMID 34179825 DOI: 10.1038/s43018-021-00183-y  0.637
2021 Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, ... ... Jain RK, et al. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. PMID 33431577 DOI: 10.1136/gutjnl-2020-322493  0.629
2020 Nia HT, Munn LL, Jain RK. Physical traits of cancer. Science (New York, N.Y.). 370. PMID 33122355 DOI: 10.1126/science.aaz0868  0.672
2020 Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907939 DOI: 10.1073/Pnas.2002806117  0.7
2020 Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature Protocols. PMID 32681151 DOI: 10.1038/S41596-020-0328-2  0.796
2020 Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, et al. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Research. PMID 32641416 DOI: 10.1158/0008-5472.Can-20-0291  0.313
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Jain RK, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  0.345
2020 Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, ... ... Jain RK, et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nature Biotechnology. PMID 32042168 DOI: 10.1038/S41587-019-0404-8  0.362
2020 Martin JD, Cabral H, Stylianopoulos T, Jain RK. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 32034288 DOI: 10.1038/S41571-019-0308-Z  0.326
2020 Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RK. Combining microenvironment normalization strategies to improve cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015113 DOI: 10.1073/Pnas.1919764117  0.419
2019 Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK. CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proceedings of the National Academy of Sciences of the United States of America. PMID 31879345 DOI: 10.1073/Pnas.1910856117  0.704
2019 Seano G, Jain RK. Vessel co-option in glioblastoma: emerging insights and opportunities. Angiogenesis. PMID 31679081 DOI: 10.1007/S10456-019-09691-Z  0.333
2019 Arvanitis CD, Ferraro GB, Jain RK. The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nature Reviews. Cancer. PMID 31601988 DOI: 10.1038/S41568-019-0205-X  0.311
2019 Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T. Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31558474 DOI: 10.1158/1078-0432.Ccr-19-1739  0.385
2019 Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Jain RK, Cobbold M, et al. Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC. Hepatology (Baltimore, Md.). PMID 31378984 DOI: 10.1002/Hep.30889  0.708
2019 Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK. Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 165-174. PMID 31099649 DOI: 10.1200/EDBK_237987  0.722
2019 Amoozgar Z, Jain RK, Duda DG. Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System? Cancer Research. 79: 2104-2106. PMID 31043429 DOI: 10.1158/0008-5472.Can-19-0749  0.323
2019 Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040208 DOI: 10.1073/Pnas.1819889116  0.786
2019 Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, ... ... Jain RK, et al. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. 3: 230-245. PMID 30948807 DOI: 10.1038/S41551-018-0334-7  0.774
2019 Martin JD, Seano G, Jain RK. Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. Annual Review of Physiology. 81: 505-534. PMID 30742782 DOI: 10.1146/Annurev-Physiol-020518-114700  0.403
2019 Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700545 DOI: 10.1073/Pnas.1815515116  0.664
2019 Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700544 DOI: 10.1073/Pnas.1818322116  0.437
2019 Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, ... ... Jain RK, et al. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30659155 DOI: 10.1073/Pnas.1818357116  0.809
2019 Nia HT, Munn LL, Jain RK. Mapping physical tumor microenvironment and drug delivery. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30630829 DOI: 10.1158/1078-0432.Ccr-18-3724  0.683
2019 Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, et al. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nature Protocols. PMID 30617350 DOI: 10.1038/S41596-018-0105-7  0.344
2019 Talele NP, Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Michelakos T, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, ... ... Jain R, et al. Abstract A115: Use of angiotensin system inhibitors is associated with immune activation and longer survival in pancreatic ductal adenocarcinoma patients Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A115  0.661
2019 Chen IX, Chauhan VP, Posada J, Ng MR, Wu M, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Abstract 2744: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2744  0.627
2019 Grahovac J, Han S, Liu H, Duquette M, Luengo A, Schanne D, Liss AS, Heiden MGV, Jain RK, Boucher Y. Abstract B06: The angiotensin receptor blocker and partial PPARγ agonist telmisartan inhibits the growth of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B06  0.322
2019 Liu H, Ho WW, Naxerova K, Grahovac J, Nia H, Chen I, Posada JM, Schanne DH, Pinter M, Crain J, Qi X, Clark JW, Hong TS, Ryan DP, Huang P, ... ... Jain RK, et al. Abstract A18: Angiotensin receptor blockers normalize the pancreatic ductal adenocarcinoma stroma by reprogramming carcinoma-associated fibroblasts Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A18  0.787
2019 Jain RK. Abstract SY33-01: Improving immunotherapy of cancer by normalizing tumor vessels Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy33-01  0.421
2019 Ferraro G, Arvanitis C, Askoxylakis V, Guo Y, Datta M, Bernabeu M, Fukumura D, McDannold N, Jain R. BSCI-09. MECHANISMS OF ENHANCED DRUG DELIVERY IN BRAIN METASTASES WITH FOCUSED ULTRASOUND-INDUCED BLOOD-TUMOR BARRIER DISRUPTION Neuro-Oncology Advances. 1: i2-i2. DOI: 10.1093/noajnl/vdz014.007  0.541
2019 Flores-Toro J, Luo D, Campbell J, Charo I, Singh R, Schall T, Datta M, Jain R, Mitchell D, Harrison J. IMMU-05. DISRUPTION OF THE CCR2 CHEMOKINE RECEPTOR PATHWAY OVERCOMES THERAPEUTIC RESISTANCE TO PD-1 BLOCKADE IN MALIGNANT GLIOMA Neuro-Oncology. 21: vi119-vi120. DOI: 10.1093/Neuonc/Noz175.499  0.31
2019 Seano G, Griveau A, Shelton S, Krishnan S, Wang N, Kloepper J, Huillard E, Batchelor T, Stemmer-Rachamimov A, Aghi M, Jain R, Rowitch D. OS12.4 In vivo dynamics and targeting of vessel co-option in glioma Neuro-Oncology. 21: iii23-iii23. DOI: 10.1093/Neuonc/Noz126.076  0.362
2018 Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassará A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, ... ... Jain RK, et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biology. PMID 30598531 DOI: 10.1038/S41556-018-0256-3  0.325
2018 Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Scientific Reports. 8: 17062. PMID 30459364 DOI: 10.1038/S41598-018-34820-X  0.362
2018 Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP. Inducible Nitric Oxide Synthase and CD11bGr1 Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Lymphatic Research and Biology. PMID 30358484 DOI: 10.1089/Lrb.2018.0013  0.369
2018 Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, ... ... Jain RK, et al. A homing system targets therapeutic T cells to brain cancer. Nature. PMID 30185905 DOI: 10.1038/S41586-018-0499-Y  0.3
2018 Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Translational Cancer Research. 7: S16-S20. PMID 30175050 DOI: 10.21037/Tcr.2017.12.17  0.377
2018 Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150398 DOI: 10.1073/Pnas.1807105115  0.771
2018 Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, ... Jain RK, et al. Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer. International Journal of Radiation Oncology, Biology, Physics. PMID 29859792 DOI: 10.1016/J.Ijrobp.2018.04.026  0.325
2018 Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, ... ... Jain RK, et al. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. PMID 29766399 DOI: 10.1007/S10456-018-9613-X  0.302
2018 Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine. PMID 29686425 DOI: 10.1038/S41591-018-0014-X  0.366
2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, ... ... Jain RK, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. PMID 29681511 DOI: 10.1016/J.Ccell.2018.03.020  0.362
2018 Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nature Protocols. 13: 1091-1105. PMID 29674756 DOI: 10.1038/Nprot.2018.020  0.799
2018 Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proceedings of the National Academy of Sciences of the United States of America. PMID 29626132 DOI: 10.1073/Pnas.1718917115  0.669
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends in Cancer. 4: 292-319. PMID 29606314 DOI: 10.1016/J.Trecan.2018.02.005  0.407
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends in Cancer. 4: 258-259. PMID 29606306 DOI: 10.1016/J.Trecan.2018.02.010  0.427
2018 Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, ... ... Jain RK, et al. Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Science Translational Medicine. 10. PMID 29540614 DOI: 10.1126/Scitranslmed.Aag0945  0.346
2018 Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 29508855 DOI: 10.1038/Nrclinonc.2018.29  0.317
2018 Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, ... ... Jain RK, et al. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440379 DOI: 10.1073/Pnas.1719966115  0.332
2018 Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Duda GD, Allen JN, Blaszkowsky LS, Ferrone C, Parikh AR, Nipp RD, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, ... Jain RK, et al. Potentially curative combination of TGF-b1 inhibitor losartan and FOLFIRINOX (FFX) for locally advanced pancreatic cancer (LAPC): R0 resection rates and preliminary survival data from a prospective phase II study. Journal of Clinical Oncology. 36: 4116-4116. DOI: 10.1200/Jco.2018.36.15_Suppl.4116  0.307
2018 Leone JP, Hu J, Barry WT, Duda DG, Gerstner ER, Jain RK, Tan S, Lawler ES, Winer EP, Lin NU, Tolaney SM. A phase II study of cabozantinib (cabo) alone or in combination with trastuzumab (T) in patients (pts) with breast cancer brain metastases (BCBM). Journal of Clinical Oncology. 36: 1026-1026. DOI: 10.1200/Jco.2018.36.15_Suppl.1026  0.303
2018 Jain RK. Abstract SY38-03: Microenvironment dictates differential responseof primary tumor versus metastases Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Sy38-03  0.344
2018 Ng MR, Sabbatino F, Duquette M, Naxerova K, Badeaux M, Ferraro GB, Chin SM, Bezwada D, Brachtel EF, Ferrone S, Jain RK. Abstract LB-057: Hypoxia regulation of antigen presentation machinery expression in breast cancer Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Lb-057  0.634
2018 Arvanitis C, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro G, Bernabeu M, Fukumura D, McDannold N, Jain R. CADD-32. MECHANISMS OF ENHANCED DRUG DELIVERY IN BRAIN TUMORS WITH FOCUSED ULTRASOUND-INDUCED TRANSIENT BLOOD-TUMOR BARRIER DISRUPTION Neuro-Oncology. 20: vi281-vi281. DOI: 10.1093/Neuonc/Noy148.1172  0.593
2017 Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I. Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 8: 108292-108302. PMID 29312532 DOI: 10.18632/Oncotarget.22660  0.376
2017 Reardon DA, Lassman AB, Schiff D, Yunus SA, Gerstner ER, Cloughesy TF, Lee EQ, Gaffey SC, Barrs J, Bruno J, Muzikansky A, Duda DG, Jain RK, Wen PY. Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. Cancer. PMID 29266174 DOI: 10.1002/Cncr.31172  0.326
2017 Li W, Liu Y, Yang W, Han X, Li S, Liu H, Gerweck LE, Fukumura D, Loeffler JS, Yang BB, Jain RK, Huang P. MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. Journal of Neuro-Oncology. PMID 29081036 DOI: 10.1007/S11060-017-2646-Y  0.333
2017 Pinter M, Jain RK. Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Science Translational Medicine. 9. PMID 28978752 DOI: 10.1126/Scitranslmed.Aan5616  0.373
2017 Zhang N, Chen J, Ferraro G, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Experimental Neurology. PMID 28911884 DOI: 10.1016/J.Expneurol.2017.09.008  0.708
2017 Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, ... ... Jain RK, et al. Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900008 DOI: 10.1073/Pnas.1710754114  0.365
2017 Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, et al. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. The Journal of Clinical Investigation. PMID 28691930 DOI: 10.1172/Jci93182  0.401
2017 Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.). 357: 55-60. PMID 28684519 DOI: 10.1126/Science.Aai8515  0.662
2017 Askoxylakis V, Arvanitis CD, Wong CSF, Ferraro GB, Jain RK. Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors. Advanced Drug Delivery Reviews. PMID 28648712 DOI: 10.1016/J.Addr.2017.06.011  0.369
2017 Levin VA, Chan J, Datta M, Yee JL, Jain RK. Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab. Journal of Neuro-Oncology. PMID 28631191 DOI: 10.1007/S11060-017-2528-3  0.687
2017 Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, ... ... Jain RK, et al. Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28600474 DOI: 10.1158/1078-0432.Ccr-17-0256  0.657
2017 Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, ... ... Jain RK, et al. The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation. Science Translational Medicine. 9. PMID 28539475 DOI: 10.1126/Scitranslmed.Aal4682  0.66
2017 De Palma M, Jain RK. CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin? Immunity. 46: 773-775. PMID 28514684 DOI: 10.1016/J.Immuni.2017.04.015  0.309
2017 Mpekris F, Baish JW, Stylianopoulos T, Jain RK. Role of vascular normalization in benefit from metronomic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28174262 DOI: 10.1073/Pnas.1700340114  0.419
2017 Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096337 DOI: 10.1073/Pnas.1525387114  0.676
2017 Wang N, Jain RK, Batchelor TT. New Directions in Anti-Angiogenic Therapy for Glioblastoma. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28083806 DOI: 10.1007/S13311-016-0510-Y  0.361
2017 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WT, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin J, Huang Y, Maimon N, Reissfelder C, ... ... Jain RK, et al. Abstract PR06: VEGF-targeted therapy induces extracellular matrix remodeling and increases mechanical barriers to therapy in colorectal cancer liver metastases Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Pr06  0.755
2017 Jain RK. Abstract IA01: Reengineering the tumor microenvironment to improve cancer treatment: Bench to bedside Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Ia01  0.447
2017 Ferraro GB, Kodack DP, Askoxylakis V, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao AZ, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, ... ... Jain RK, et al. Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Cancer Research. 77: 5008-5008. DOI: 10.1158/1538-7445.Am2017-5008  0.664
2017 Nia H, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan V, Jung K, Martin J, Askoxylakis V, Padera T, Fukumura D, Boucher Y, Hornicek F, ... ... Jain R, et al. Abstract 3987: Solid stress and elastic energy as measures of tumor mechanopathology Cancer Research. 77: 3987-3987. DOI: 10.1158/1538-7445.Am2017-3987  0.802
2016 Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, ... ... Jain RK, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 1. PMID 28966873 DOI: 10.1038/S41551-016-0004  0.77
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27908927 DOI: 10.1101/Cshperspect.A031195  0.387
2016 Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Reports. 6: 37949. PMID 27905494 DOI: 10.1038/Srep37949  0.696
2016 Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, ... Jain RK, et al. Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. Journal of Neuro-Oncology. PMID 27853960 DOI: 10.1007/S11060-016-2332-5  0.393
2016 Emblem KE, Jain RK. Improving treatment of liver metastases by targeting nonangiogenic mechanisms. Nature Medicine. 22: 1209-1210. PMID 27824818 DOI: 10.1038/Nm.4228  0.307
2016 Tolaney SM, Ziehr DR, Guo H, Ng MR, Barry WT, Higgins MJ, Isakoff SJ, Brock JE, Ivanova EV, Paweletz CP, Demeo MK, Ramaiya NH, Overmoyer BA, Jain RK, Winer EP, et al. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. The Oncologist. PMID 27789775 DOI: 10.1634/Theoncologist.2016-0229  0.311
2016 Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Translational Oncology. 9: 431-437. PMID 27751347 DOI: 10.1016/J.Tranon.2016.07.004  0.309
2016 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, ... ... Jain RK, et al. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Science Translational Medicine. 8: 360ra135. PMID 27733559 DOI: 10.1126/Scitranslmed.Aaf5219  0.741
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. PMID 27663981 DOI: 10.1101/Cshperspect.A027094  0.429
2016 Menter AR, Carroll NM, Sakoda LC, Delate T, Hornbrook MC, Jain RK, Kushi LH, Quinn VP, Ritzwoller DP. Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer. Clinical Lung Cancer. PMID 27637408 DOI: 10.1200/Jco.2014.32.15_Suppl.8069  0.315
2016 Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, ... ... Jain RK, et al. Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discovery. PMID 27246539 DOI: 10.1158/2159-8290.Cd-15-1177  0.763
2016 Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, ... ... Jain RK, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044098 DOI: 10.1073/Pnas.1525360113  0.731
2016 Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, ... ... Jain RK, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044097 DOI: 10.1073/Pnas.1525349113  0.725
2016 Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, ... ... Jain RK, et al. PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26861455 DOI: 10.1158/1078-0432.Ccr-15-1839  0.344
2016 Fukumura D, Incio J, Shankaraiah R, Jain RK. Obesity and cancer: an angiogenic and inflammatory link. Microcirculation (New York, N.Y. : 1994). PMID 26808917 DOI: 10.1111/Micc.12270  0.329
2016 Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, ... ... Jain RK, et al. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine. 8: 320ra4. PMID 26738797 DOI: 10.1126/Scitranslmed.Aad0293  0.572
2016 Askoxylakis V, Ferraro GB, Kodack DP, Badeaux M, Shankaraiah RC, Seano G, Kloepper J, Vardam T, Martin JD, Naxerova K, Bezwada D, Qi X, Selig MK, Brachtel E, Duda DG, ... ... Jain RK, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. Journal of the National Cancer Institute. 108. PMID 26547932 DOI: 10.1093/Jnci/Djv313  0.659
2016 Gerstner ER, Jain RK, Batchelor TT. Value of correlative biomarkers in understanding tumor biology Translational Cancer Research. 5: 211-212. DOI: 10.21037/7193  0.373
2016 Ng MR, Jain RK. Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels Translational Cancer Research. 5. DOI: 10.21037/11295  0.367
2016 Ferraro GB, Askoxylakis V, Kodack DP, Badeaux M, Fukumura D, Engelman JA, Jain RK. Abstract A48: Ado-trastuzumab emtansine (T-DM1) controls tumor progression of established HER2-positive breast cancer brain metastases in mice Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A48  0.377
2016 Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Jain R. Abstract P6-17-02: Ado-trastuzumab emtansine (T-DM1) is effective against established HER2-positive breast cancer brain metastases in mice Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P6-17-02  0.337
2016 Yan S, Chatterjee S, Vardam T, Kitahara S, Hato T, Roberge S, Askoxylakis V, Duquette M, Fukumura D, Xu L, Jain R. Abstract A12: Microenvironmental Interleukin-6 induced activation of STAT3 signaling in medulloblastoma: Implications for molecular pathology and therapy Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-A12  0.319
2016 Grahovac J, Han S, Liu H, Jain R, Boucher Y. Abstract B41: The angiotensin receptor blocker telmisartan inhibits the growth of pancreatic ductal adenocarcinoma and improves survival Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B41  0.341
2016 Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek KH, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, ... ... Jain RK, et al. Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-347  0.407
2016 Incio J, Liu H, Suboj P, Min S, Chen I, Ng M, Nia H, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari N, Han X, Chauhan V, ... ... Jain R, et al. Abstract 898: Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy Cancer Research. 76: 898-898. DOI: 10.1158/1538-7445.Am2016-898  0.772
2016 Jung K, Heishi T, Yun A, Padera TP, Jain RK, Fukumura D. Abstract 4195: Targeting the immune microenvironment to improve colorectal cancer anti-angiogenic therapy Cancer Research. 76: 4195-4195. DOI: 10.1158/1538-7445.Am2016-4195  0.38
2016 Emblem KE, Gerstner ER, Sorensen G, Rosen BR, Wen PY, Batchelor TT, Jain RK. Abstract 3975: Matrix-depleting anti-hypertensives decompress tumor blood vessels and improve perfusion in patients with glioblastomas receiving anti-angiogenic therapy Cancer Research. 76: 3975-3975. DOI: 10.1158/1538-7445.Am2016-3975  0.408
2016 Kashany ZH, Ahn S, Nia HT, Tshikudi DM, Grodzinsky A, Jain RK, Nadkarni SK. Laser speckle micro rheology for micro-mechanical mapping of bio-materials(Conference Presentation) Proceedings of Spie. 9707: 970702. DOI: 10.1117/12.2213761  0.696
2016 Peterson T, Kirkpatrick N, Huang Y, Farrar C, Marjit K, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun W, Vardam T, Snuderl M, Goveia J, Chatterjee S, ... ... Jain R, et al. Tmic-07. Dual Inhibition Of Ang-2 And Vegf Receptors Normalizes Tumor Vasculature And Prolongs Survival In Glioblastoma By Altering Macrophages Neuro-Oncology. 18. DOI: 10.1093/Neuonc/Now212.847  0.343
2016 Riedemann L, Kloepper J, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung R, Datta M, Song JW, Askoxylakis V, Taylor J, Lu-Emerson C, Batista A, Kirkpatrick N, ... ... Jain R, et al. IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS Neuro-Oncology. 18: vi95-vi95. DOI: 10.1093/Neuonc/Now212.396  0.382
2015 Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. Plos One. 10: e0141392. PMID 26641266 DOI: 10.1371/Journal.Pone.0141392  0.366
2015 Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, ... ... Jain RK, et al. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: 14325-14330. PMID 26578779 DOI: 10.1073/Pnas.1518808112  0.342
2015 Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L. Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554010 DOI: 10.1073/Pnas.1512570112  0.346
2015 Stylianopoulos T, Jain RK. Design considerations for nanotherapeutics in oncology. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26282377 DOI: 10.1016/J.Nano.2015.07.015  0.342
2015 Datta M, Via LE, Chen W, Baish JW, Xu L, Barry CE, Jain RK. Mathematical Model of Oxygen Transport in Tuberculosis Granulomas. Annals of Biomedical Engineering. PMID 26253038 DOI: 10.1007/S10439-015-1415-3  0.676
2015 Batista A, Riedemann L, Vardam T, Jain RK. Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment. Cancer Journal (Sudbury, Mass.). 21: 307-13. PMID 26222083 DOI: 10.1097/Ppo.0000000000000125  0.381
2015 Jain RK, Fukumura D, Duda DG. From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey. Cancer Journal (Sudbury, Mass.). 21: 235-6. PMID 26222072 DOI: 10.1097/Ppo.0000000000000136  0.371
2015 Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: E3454. PMID 26080434 DOI: 10.1073/Pnas.1507225112  0.334
2015 Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer Journal (Sudbury, Mass.). 21: 137. PMID 26049690 DOI: 10.1097/Ppo.0000000000000119  0.403
2015 Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S. A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma. Neuro-Oncology. PMID 26008604 DOI: 10.1093/Neuonc/Nov085  0.358
2015 Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK. Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 1197-213. PMID 25713439 DOI: 10.1200/Jco.2014.55.9575  0.386
2015 Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, ... Jain RK, et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. Journal of the National Cancer Institute. 107. PMID 25710962 DOI: 10.1093/Jnci/Djv017  0.306
2015 Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proceedings of the National Academy of Sciences of the United States of America. 112: 1827-32. PMID 25624495 DOI: 10.1073/Pnas.1424563112  0.71
2015 Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK. Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: 1547-52. PMID 25605928 DOI: 10.1073/Pnas.1424024112  0.361
2015 Naxerova K, Jain RK. Using tumour phylogenetics to identify the roots of metastasis in humans. Nature Reviews. Clinical Oncology. 12: 258-72. PMID 25601447 DOI: 10.1038/Nrclinonc.2014.238  0.657
2015 Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.). 61: 1591-602. PMID 25529917 DOI: 10.1002/Hep.27665  0.341
2015 Chen Y, Reiberger T, Ramjiawan R, Ng MR, Hato T, Unan EC, Reddy TP, Ochiai H, Huang P, Zhu AX, Jain RK, Duda DG. Abstract B79: CXCR4 inhibition facilitates anti-PD-1 immunotherapy by reprogramming the tumor microenvironment during sorafenib treatment in hepatocellular carcinoma Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-B79  0.348
2015 Jain RK. Abstract IA03: Antiangiogenesis strategies revisited: From starving tumors to alleviating hypoxia Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-Ia03  0.422
2015 Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Abstract B19: Anti-VEGF treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-B19  0.343
2015 Seano G, Chiaverina G, Gagliardi PA, Blasio Ld, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L. Abstract A13: Endothelial podosome rosettes regulate vascular branching in tumor angiogenesis Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-A13  0.322
2015 Incio J, Tam J, Rahbari N, Suboj P, McManus D, Chin S, Vardan-Kaur T, Batista A, Babycutty S, Jung K, Khachatryan A, Shibuya M, Soares R, Duda D, Jain RK, et al. Abstract LB-267: Role of VEGFR-1 signaling in obesity-induced tumor progression Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-267  0.303
2015 Incio J, McManus D, Suboj P, Rahbari N, Chin SM, Babycutty S, Vardan-Kaur T, Huang Y, Jung K, Duda D, Soares R, Fukumura D, Jain RK. Abstract LB-203: Obesity promotes resistance to anti-VEGF therapy in breast cancer via pro-inflammatory and angiogenic pathways Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-203  0.315
2015 Jain RK, Sharma P. Part 2: Targeting Cancer Pathways: The Tumor Microenvironment Science. 347: 680.3-680. DOI: 10.1126/Science.347.6222.680-C  0.405
2015 Griveau A, Shelton S, Tien A, Seano G, Yuen T, Sabo J, Lau J, Jahangiri A, Huillard E, Phillips J, Persson A, Oldham M, Weiss W, Aghi M, Stiles C, ... ... Jain R, et al. ANGI-04Olig2 REGULATES Wnt7b EXPRESSION AND VASCULATURE CHARACTERISTICS IN GLIOMA Neuro-Oncology. 17: v41.4-v41. DOI: 10.1093/Neuonc/Nov207.04  0.352
2014 Jain RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell. 26: 605-22. PMID 25517747 DOI: 10.1016/J.Ccell.2014.10.006  0.409
2014 Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK. Seeds and soil: unraveling the role of local tumor stroma in distant metastasis. Journal of the National Cancer Institute. 106. PMID 25082335 DOI: 10.1093/Jnci/Dju187  0.416
2014 Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 26: 14-5. PMID 25026209 DOI: 10.1016/J.Ccr.2014.06.003  0.645
2014 Jain RK, Martin JD, Stylianopoulos T. The role of mechanical forces in tumor growth and therapy. Annual Review of Biomedical Engineering. 16: 321-46. PMID 25014786 DOI: 10.1146/Annurev-Bioeng-071813-105259  0.409
2014 Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK. Hypermutable DNA chronicles the evolution of human colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1889-98. PMID 24753616 DOI: 10.1073/Pnas.1400179111  0.665
2014 Jain RK. An indirect way to tame cancer. Scientific American. 310: 46-53. PMID 24640331 DOI: 10.1038/Scientificamerican0214-46  0.312
2014 Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER. Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation. The Oncologist. 19: 75-81. PMID 24309981 DOI: 10.1634/Theoncologist.2013-0101  0.307
2014 Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology (Baltimore, Md.). 59: 1435-47. PMID 24242874 DOI: 10.1002/Hep.26790  0.343
2014 Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, et al. mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Cancer Discovery. 4: 42-52. PMID 24163374 DOI: 10.1158/2159-8290.Cd-13-0315  0.303
2014 Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG. Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold. Inorganic Chemistry. 53: 1900-15. PMID 24143874 DOI: 10.1021/Ic401587R  0.311
2014 Snurdel M, Batista A, Kirkpatrick N, Almodovar C, Riedemann L, Peterson T, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain R. Abstract IA17: Targeting placental growth factor/ neuropilin-1 pathway inhibits growth and spread of medulloblastoma Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-Ia17  0.392
2014 Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, ... ... Jain RK, et al. INCREASED PERFUSION DUE TO VASCULAR NORMALIZATION IMPROVES OXYGENATION AND SURVIVAL IN GLIOBLASTOMA PATIENTS TREATED WITH CEDIRANIB WITH OR WITHOUT CHEMORADIATION Neuro-Oncology. 16: iii12-iii12. DOI: 10.1093/Neuonc/Nou206.42  0.395
2014 Reiberger T, Chen B, Huang P, Lauwers G, Zhu A, Jain R. HCC resistance to sorafenib can be caused by hypoxia-induced SDF1a/CXCR4 upregulation leading to tumor desmoplasia and GR1+ cell infiltration Zeitschrift Fur Gastroenterologie. 52: 74. DOI: 10.1055/S-0034-1376058  0.314
2013 Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK. Benefits of vascular normalization are dose and time dependent--letter. Cancer Research. 73: 7144-6. PMID 24265277 DOI: 10.1158/0008-5472.Can-13-1989  0.305
2013 Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, ... ... Jain RK, et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 19059-64. PMID 24190997 DOI: 10.1073/Pnas.1318022110  0.4
2013 Stylianopoulos T, Jain RK. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18632-7. PMID 24167277 DOI: 10.1073/Pnas.1318415110  0.411
2013 Chauhan VP, Jain RK. Strategies for advancing cancer nanomedicine. Nature Materials. 12: 958-62. PMID 24150413 DOI: 10.1038/Nmat3792  0.63
2013 Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovi? Z, Huang P, Bawendi MG, Boucher Y, Jain RK. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nature Communications. 4: 2516. PMID 24084631 DOI: 10.1038/Ncomms3516  0.656
2013 Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nature Medicine. 19: 1178-83. PMID 23955713 DOI: 10.1038/Nm.3289  0.305
2013 Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, ... ... Jain RK, et al. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Journal of the National Cancer Institute. 105: 1188-201. PMID 23899555 DOI: 10.1093/Jnci/Djt164  0.421
2013 Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, ... ... Jain RK, et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro-Oncology. 15: 1079-87. PMID 23828240 DOI: 10.1093/Neuonc/Not082  0.376
2013 Jain RK, Munn LL, Fukumura D. Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harbor Protocols. 2013: 678-80. PMID 23818670 DOI: 10.1101/Pdb.Prot075721  0.315
2013 Jain RK, Munn LL, Fukumura D. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harbor Protocols. 2013: 561-3. PMID 23734020 DOI: 10.1101/Pdb.Prot075085  0.324
2013 Duda DG, Munn LL, Jain RK. Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling? Journal of the National Cancer Institute. 105: 762-5. PMID 23670727 DOI: 10.1093/Jnci/Djt114  0.388
2013 Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 2205-18. PMID 23669226 DOI: 10.1200/Jco.2012.46.3653  0.434
2013 Jain RK, Munn LL, Fukumura D. Measuring vascular permeability in mice. Cold Spring Harbor Protocols. 2013: 444-6. PMID 23637370 DOI: 10.1101/Pdb.Prot074344  0.311
2013 Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Research. 73: 3833-41. PMID 23633490 DOI: 10.1158/0008-5472.Can-12-4521  0.377
2013 Jain RK, Munn LL, Fukumura D. Measuring angiogenesis and hemodynamics in mice. Cold Spring Harbor Protocols. 2013: 354-8. PMID 23547161 DOI: 10.1101/Pdb.Prot073916  0.342
2013 Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, ... ... Jain RK, et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 152: 1065-76. PMID 23452854 DOI: 10.1016/J.Cell.2013.01.036  0.389
2013 Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Research. 73: 2943-8. PMID 23440426 DOI: 10.1158/0008-5472.Can-12-4354  0.397
2013 Prabhakar U, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P, Blakey DC. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Research. 73: 2412-7. PMID 23423979 DOI: 10.1158/0008-5472.Can-12-4561  0.366
2013 Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG. Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking. Nature Materials. 12: 445-51. PMID 23377294 DOI: 10.1038/Nmat3539  0.58
2013 Stylianopoulos T, Soteriou K, Fukumura D, Jain RK. Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model. Annals of Biomedical Engineering. 41: 68-77. PMID 22855118 DOI: 10.1007/S10439-012-0630-4  0.306
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznansky MC, Jain RK. Vascular normalization: a strategy to recondition the tumor immune microenvironment Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-P155  0.43
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznansky MC, Jain RK. Abstract A67: Reconditioning the tumor immune microenvironment for a breast cancer vaccine therapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-A67  0.399
2013 Duda DG, Tolaney SM, Ancukiewicz M, Winer EP, Krop IE, Jain RK. Abstract LB-81: A study of circulating biomarkers of angiogenesis and inflammation in ER+ breast cancer (BC) versus triple-negative breast cancer (TNBC) patients enrolled in a phase II study of preoperative treatment with 1 cycle of Bevacizumab followed by standard chemo Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-81  0.333
2013 Stylianopoulos T, Martin JD, Jain S, Snuderl M, Chauhan VP, Munn LL, Boucher Y, Jain RK. Abstract LB-348: Evolution of physical forces in the tumor microenvironment and implications for therapeutic resistance. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-348  0.687
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznanasky MC, Jain RK. Abstract LB-344: Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-344  0.393
2013 Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Taylor J, Davidson C, Huang Y, Riedemann L, Ivy SP, Duda GD, Ancukiewicz M, Plotkin SR, Chi A, Gerstner ER, Eichler AF, ... ... Jain RK, et al. Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-339  0.378
2013 Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJH, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Abstract LB-297: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-297  0.339
2013 Blauvelt D, Mohan N, Bouma B, Jain R, Padera T, Vakoc B. Abstract 713: Three-dimensionalin vivoblood flow mapping in tumors using optical frequency domain imaging. Cancer Research. 73: 713-713. DOI: 10.1158/1538-7445.Am2013-713  0.35
2013 Coffee EM, Faber AC, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, J E, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, et al. Abstract C263: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C263  0.302
2013 Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Abstract C1: Functional normalization of the breast cancer vasculature through activation of Tie2 using a vascular-endothelial protein tyrosine phosphatase inhibitor. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C1  0.419
2013 Jain RK, Chauhan VP, Duda DG. Vascular and Interstitial Biology of Tumors Abeloff's Clinical Oncology: Fifth Edition. 108-126.e6. DOI: 10.1016/B978-1-4557-2865-7.00008-4  0.629
2012 Jain RK. Delivery of molecular and cellular medicine to solid tumors. Advanced Drug Delivery Reviews. 64: 353-365. PMID 24511174 DOI: 10.1016/J.Addr.2012.09.011  0.416
2012 Jain RK, Munn LL, Fukumura D. Liver tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209146 DOI: 10.1101/Pdb.Prot072371  0.372
2012 Jain RK, Munn LL, Fukumura D. Pancreatic tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209145 DOI: 10.1101/Pdb.Prot072363  0.359
2012 Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse tail. Cold Spring Harbor Protocols. 2012: 1177-8. PMID 23118364 DOI: 10.1101/Pdb.Prot072108  0.381
2012 Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, ... ... Jain RK, et al. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proceedings of the National Academy of Sciences of the United States of America. 109: E3119-27. PMID 23071298 DOI: 10.1073/Pnas.1216078109  0.352
2012 Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, ... Jain RK, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 109: 17561-6. PMID 23045683 DOI: 10.1073/Pnas.1215397109  0.399
2012 Jain RK, Munn LL, Fukumura D. Mammary fat pad tumor preparation in mice. Cold Spring Harbor Protocols. 2012: 1115-6. PMID 23028076 DOI: 10.1101/Pdb.Prot071514  0.401
2012 Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L. TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. 109: 16618-23. PMID 22996328 DOI: 10.1073/Pnas.1117610109  0.778
2012 Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 15101-8. PMID 22932871 DOI: 10.1073/Pnas.1213353109  0.792
2012 Jain RK, Munn LL, Fukumura D. Rabbit ear chambers. Cold Spring Harbor Protocols. 2012: 813-14. PMID 22753607 DOI: 10.1101/Pdb.Prot070045  0.307
2012 Kozin SV, Duda DG, Munn LL, Jain RK. Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? Journal of the National Cancer Institute. 104: 899-905. PMID 22572994 DOI: 10.1093/Jnci/Djs239  0.385
2012 Goel S, Fukumura D, Jain RK. Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology. Proceedings of the National Academy of Sciences of the United States of America. 109: E1214. PMID 22550180 DOI: 10.1073/Pnas.1203794109  0.376
2012 Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnology. 7: 383-8. PMID 22484912 DOI: 10.1038/Nnano.2012.45  0.629
2012 Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D. Multistage nanoparticles for improved delivery into tumor tissue. Methods in Enzymology. 508: 109-30. PMID 22449923 DOI: 10.1016/B978-0-12-391860-4.00006-9  0.398
2012 Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D. A transient parabiosis skin transplantation model in mice. Nature Protocols. 7: 763-70. PMID 22441295 DOI: 10.1038/Nprot.2012.032  0.366
2012 Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG. Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nature Protocols. 7: 756-62. PMID 22441294 DOI: 10.1038/Nprot.2012.031  0.376
2012 Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK. An isolated tumor perfusion model in mice. Nature Protocols. 7: 749-55. PMID 22441293 DOI: 10.1038/Nprot.2012.030  0.402
2012 Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia (New York, N.Y.). 14: 84-94. PMID 22431917 DOI: 10.1593/Neo.111600  0.389
2012 Goel S, Wong AH, Jain RK. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harbor Perspectives in Medicine. 2: a006486. PMID 22393532 DOI: 10.1101/Cshperspect.A006486  0.372
2012 Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). Plos One. 7: e26331. PMID 22347360 DOI: 10.1371/Journal.Pone.0026331  0.379
2012 Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL. Mechanical compression drives cancer cells toward invasive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 109: 911-6. PMID 22203958 DOI: 10.1073/Pnas.1118910109  0.334
2012 Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, Wang M, Wen PY, Ivy P, Batchelor TT, Jain RK. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Research. 72: 402-7. PMID 22127927 DOI: 10.1158/0008-5472.Can-11-2464  0.388
2012 Pinho MC, Polaskova P, Jennings D, Wen PY, Jain RK, Sorensen AG, Gerstner ER, Batchelor T. Impact of adjuvant anti-VEGF therapy on treatment-related pseudoprogression in patients with newly diagnosed glioblastoma receiving chemoradiation with or without anti-VEGF therapy. Journal of Clinical Oncology. 30: 2025-2025. DOI: 10.1200/Jco.2012.30.15_Suppl.2025  0.322
2012 Polaskova P, Pinho MC, Kalpathy-Cramer J, Guimaraes AR, Wen PY, Sorensen AG, Jain RK, Batchelor T, Gerstner ER. Effects of cediranib (VEGF signaling inhibitor) on edema in newly diagnosed glioblastoma patients during initial chemoradiation. Journal of Clinical Oncology. 30: 2012-2012. DOI: 10.1200/Jco.2012.30.15_Suppl.2012  0.304
2012 Lu-Emerson C, Snuderl M, Davidson C, Kirkpatrick ND, Huang Y, Duda DG, Ancukiewicz M, Stemmer-Rachamimov A, Batchelor T, Jain RK. Effect of antiangiogenic therapy on tumor-associated macrophages in recurrent glioblastoma. Journal of Clinical Oncology. 30: 2010-2010. DOI: 10.1200/Jco.2012.30.15_Suppl.2010  0.341
2012 Gerstner ER, Emblem KE, Chi AS, Eichler AF, Hochberg F, Drappatz J, Quant EC, Norden AD, Pinho MC, Polaskova P, Jennings D, Ancukiewicz M, Ivy SP, Wen PY, Jain RK, et al. Effects of cediranib, a VEGF signaling inhibitor, in combination with chemoradiation on tumor blood flow and survival in newly diagnosed glioblastoma. Journal of Clinical Oncology. 30: 2009-2009. DOI: 10.1200/Jco.2012.30.15_Suppl.2009  0.318
2012 Kodack D, Chung E, Yamashita H, Incio J, Peters A, Song Y, Ager E, Huang Y, Farrar C, Lussiez A, Goel S, Snuderl M, Kamoun W, Hiddingh L, Tannous B, ... ... Jain R, et al. Abstract P3-12-03: Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-P3-12-03  0.364
2012 Stylianopoulos T, Martin JD, Chauhan VP, Munn LL, Jain RK. Residual stresses in solid tumors: Implications to tumor growth and drug delivery Asme 2012 Summer Bioengineering Conference, Sbc 2012. 207-208. DOI: 10.1115/SBC2012-80235  0.635
2011 Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annual Review of Chemical and Biomolecular Engineering. 2: 281-98. PMID 22432620 DOI: 10.1146/Annurev-Chembioeng-061010-114300  0.673
2011 Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angewandte Chemie (International Ed. in English). 50: 11417-20. PMID 22113800 DOI: 10.1002/Anie.201104449  0.661
2011 Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiological Reviews. 91: 1071-121. PMID 21742796 DOI: 10.1152/Physrev.00038.2010  0.44
2011 Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences of the United States of America. 108: 11596-601. PMID 21709229 DOI: 10.1073/Pnas.1104225108  0.637
2011 Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nature Reviews. Drug Discovery. 10: 417-27. PMID 21629292 DOI: 10.1038/Nrd3455  0.319
2011 Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis Nature. 473: 298-307. PMID 21593862 DOI: 10.1038/Nature10144  0.333
2011 Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Research. 71: 4527-38. PMID 21571860 DOI: 10.1158/0008-5472.Can-10-4376  0.327
2011 Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Research. 71: 3745-52. PMID 21507932 DOI: 10.1158/0008-5472.Can-10-2991  0.331
2011 Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK. The biology of brain metastases-translation to new therapies. Nature Reviews. Clinical Oncology. 8: 344-56. PMID 21487419 DOI: 10.1038/Nrclinonc.2011.58  0.358
2011 Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3638-48. PMID 21459800 DOI: 10.1158/1078-0432.Ccr-10-2456  0.672
2011 Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG. Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model. Plos One. 6: e17228. PMID 21390238 DOI: 10.1371/Journal.Pone.0017228  0.41
2011 Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nature Reviews. Clinical Oncology. 8: 292-301. PMID 21386818 DOI: 10.1038/Nrclinonc.2011.30  0.335
2011 Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2074-80. PMID 21349998 DOI: 10.1158/1078-0432.Ccr-10-2636  0.382
2011 Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 3725-30. PMID 21321210 DOI: 10.1073/Pnas.1100446108  0.318
2011 Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proceedings of the National Academy of Sciences of the United States of America. 108: 2909-14. PMID 21282607 DOI: 10.1073/Pnas.1018892108  0.795
2011 Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L. TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1415-24. PMID 21278244 DOI: 10.1158/1078-0432.Ccr-10-2429  0.304
2011 Huang Y, Snuderl M, Jain RK. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity. Cancer Cell. 19: 1-2. PMID 21251607 DOI: 10.1016/J.Ccr.2011.01.005  0.398
2011 Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proceedings of the National Academy of Sciences of the United States of America. 108: 2426-31. PMID 21245339 DOI: 10.1073/Pnas.1018382108  0.652
2011 Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proceedings of the National Academy of Sciences of the United States of America. 108: 1799-803. PMID 21224417 DOI: 10.1073/Pnas.1018154108  0.357
2011 di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Research. 71: 19-28. PMID 21199795 DOI: 10.1158/0008-5472.Can-10-2602  0.385
2011 Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK. C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 302-7. PMID 21173223 DOI: 10.1073/Pnas.1016917108  0.359
2011 Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide Journal of Neuro-Oncology. 103: 325-332. PMID 20821342 DOI: 10.1007/S11060-010-0390-7  0.325
2011 Jain RK. Abstract IA4: Normalizing the tumor microenvironment to enhance therapeutic outcome Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Ia4  0.426
2011 Heishi T, Tsukada K, Huang Y, Kozin S, Jain RK, Fukumura D. Abstract LB-288: Restoration of peri-vascular nitric oxide gradient radio-sensitizes murine breast cancers via vascular normalization. Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-288  0.412
2011 Liu J, Liao S, Diop B, Chen W, Goel S, Huang Y, Boucher Y, Jain RK, Xu L. Abstract 715: TGF-beta blockade improves the distribution and efficacy of chemotherapeutic agents in breast carcinoma Cancer Research. 71: 715-715. DOI: 10.1158/1538-7445.Am2011-715  0.316
2011 Wong CR, Stylianopoulos T, Bhaumik J, Cui J, Martin J, Chauhan V, Popović Z, Chen O, Jain R, Fukumura D, Bawendi M. Abstract 548: Multistage nanoparticle delivery system for deep penetration into solid tumor Cancer Research. 71: 548-548. DOI: 10.1158/1538-7445.Am2011-548  0.672
2011 Liao S, Liu J, Jain RK, Xu L. Abstract 1579: TGF-β blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma model Cancer Research. 71: 1579-1579. DOI: 10.1158/1538-7445.Am2011-1579  0.329
2010 Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK. Malignant cells facilitate lung metastasis by bringing their own soil. Proceedings of the National Academy of Sciences of the United States of America. 107: 21677-82. PMID 21098274 DOI: 10.1073/Pnas.1016234107  0.373
2010 Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophysical Journal. 99: 3119-28. PMID 21081058 DOI: 10.1016/J.Bpj.2010.08.065  0.766
2010 Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG. A nanoparticle size series for in vivo fluorescence imaging. Angewandte Chemie (International Ed. in English). 49: 8649-52. PMID 20886481 DOI: 10.1002/Anie.201003142  0.635
2010 Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nature Reviews. Clinical Oncology. 7: 653-64. PMID 20838415 DOI: 10.1038/Nrclinonc.2010.139  0.403
2010 Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Research. 70: 5679-85. PMID 20631066 DOI: 10.1158/0008-5472.Can-09-4446  0.394
2010 Duda DG, Jain RK. Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required? Cancer Research. 70: 5670-3. PMID 20587530 DOI: 10.1158/0008-5472.Can-10-0119  0.37
2010 Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nature Methods. 7: 655-60. PMID 20581828 DOI: 10.1038/Nmeth.1475  0.379
2010 Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3618-27. PMID 20501615 DOI: 10.1158/1078-0432.Ccr-09-3073  0.329
2010 Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. The Oncologist. 15: 577-83. PMID 20484123 DOI: 10.1634/Theoncologist.2010-0029  0.312
2010 Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, ... ... Jain RK, et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 2817-23. PMID 20458050 DOI: 10.1200/Jco.2009.26.3988  0.317
2010 Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Research. 70: 3483-93. PMID 20406973 DOI: 10.1158/0008-5472.Can-09-3107  0.412
2010 Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G. Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib. Neuro-Oncology. 12: 466-72. PMID 20406897 DOI: 10.1093/Neuonc/Nop051  0.39
2010 Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (New York, N.Y. : 1994). 17: 206-25. PMID 20374484 DOI: 10.1111/J.1549-8719.2010.00029.X  0.418
2010 Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG. In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model. Neuro-Oncology. 12: 341-50. PMID 20308312 DOI: 10.1093/Neuonc/Nop032  0.364
2010 Jain RK, Wei J, Gullino PM. Pharmacokinetics of methotrexate in solid tumors. Journal of Pharmacokinetics and Biopharmaceutics. 7: 181-94. PMID 20218013 DOI: 10.1007/Bf01059737  0.5
2010 Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG. InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared. Journal of the American Chemical Society. 132: 470-1. PMID 20025222 DOI: 10.1021/Ja908250R  0.599
2010 Raut CP, Morgan JA, Quek RH, Boucher Y, Duda GD, Lahdenranta J, Ancukiewicz M, Eder JP, Jain RK, Demetri GD. Measurement of interstitial fluid pressure (IFP) and circulating biomarkers in soft tissue sarcoma (STS): An exploratory phase II clinical and correlative study of sorafenib (SOR) in patients with refractory STS (NCI Protocol 6948). Journal of Clinical Oncology. 28: 10091-10091. DOI: 10.1200/Jco.2010.28.15_Suppl.10091  0.34
2010 Yoon SS, Chen Y, Karl D, Choy E, Harmon DC, Kambadakone A, Sahani D, Duda DG, Jain RK, DeLaney TF. A phase II study of neoadjuvant bevacizumab and radiation therapy for resectable soft tissue sarcomas. Journal of Clinical Oncology. 28: 10023-10023. DOI: 10.1200/Jco.2010.28.15_Suppl.10023  0.379
2010 Snuderl M, Kirkpatrick ND, Walsh EC, Chung E, Kamoun WS, Peterson TE, Munn LL, Duda DG, Fukumura D, Carmeliet P, Xu L, Jain RK. Abstract LB-363: Inhibition of placental growth factor (PlGF) leads to regression of medulloblastoma Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-363  0.396
2010 Duda DG, Willett CG, Ancukiewicz M, Tomaso Ed, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Abstract LB-213: Plasma soluble VEGFR1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-213  0.305
2010 Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Jain RK, Munn LL. Abstract 4811: Compression-induced cell distension stimulates coordinated migration of mammary carcinoma cells Cancer Research. 70: 4811-4811. DOI: 10.1158/1538-7445.Am10-4811  0.329
2010 Duyverman AM, Duda DG, Kohno M, Steller EJ, Fukumura D, Jain RK. Abstract 3847: Metastasizing host stromal cells potentiate colonization of metastatic tumors Cancer Research. 70: 3847-3847. DOI: 10.1158/1538-7445.Am10-3847  0.393
2010 Kirkpatrick ND, Jain RK. Abstract 368: In vivo vessel co-option by glioma cells following chronic anti-angiogenic treatment Cancer Research. 70: 368-368. DOI: 10.1158/1538-7445.Am10-368  0.438
2010 Liu J, Liao S, Huang Y, Jain RK, Xu L. Abstract B32: TGF-β blockade improves the distribution and efficacy of chemotherapeutic agent in breast carcinoma Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B32  0.35
2009 Chi AS, Gerstner ER, Eichler AF, Chea HK, Drappatz J, Wen PY, Ivy SP, Loeffler JS, Sorensen AG, Jain RK, Batchelor TT. Phase Ib study of cediranib in combination with daily temozolomide and radiation in patients with newly diagnosed glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e13010. PMID 27962847 DOI: 10.1200/Jco.2009.27.15_Suppl.E13010  0.312
2009 Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK. Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. Plos One. 4: e8316. PMID 20016816 DOI: 10.1371/Journal.Pone.0008316  0.361
2009 Duda DG, Ancukiewicz M, Jain RK. Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 183-5. PMID 19949009 DOI: 10.1200/Jco.2009.24.8021  0.379
2009 Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Research. 69: 7905-10. PMID 19826039 DOI: 10.1158/0008-5472.Can-09-2099  0.388
2009 Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. Plos One. 4: e6525. PMID 19763275 DOI: 10.1371/Journal.Pone.0006525  0.404
2009 Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nature Medicine. 15: 1219-23. PMID 19749772 DOI: 10.1038/Nm.1971  0.336
2009 Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. The New England Journal of Medicine. 361: 358-67. PMID 19587327 DOI: 10.1056/Nejmoa0902579  0.345
2009 Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophysical Journal. 97: 330-6. PMID 19580771 DOI: 10.1016/J.Bpj.2009.03.064  0.774
2009 Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Research. 69: 5296-300. PMID 19549889 DOI: 10.1158/0008-5472.Can-09-0814  0.341
2009 Jain RK. A new target for tumor therapy New England Journal of Medicine. 360. PMID 19535806 DOI: 10.1056/Nejmcibr0902054  0.385
2009 Chi AS, Sorensen AG, Jain RK, Batchelor TT. Angiogenesis as a therapeutic target in malignant gliomas Oncologist. 14: 621-636. PMID 19487335 DOI: 10.1634/Theoncologist.2008-0272  0.343
2009 Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG. Biomarkers of response and resistance to antiangiogenic therapy. Nature Reviews. Clinical Oncology. 6: 327-38. PMID 19483739 DOI: 10.1038/Nrclinonc.2009.63  0.329
2009 Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. The American Journal of Pathology. 175: 294-302. PMID 19477947 DOI: 10.2353/Ajpath.2009.080887  0.314
2009 di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. Plos One. 4: e5123. PMID 19352490 DOI: 10.1371/Journal.Pone.0005123  0.384
2009 Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Anti-vascular endothelial growth factor therapy for malignant glioma. Current Neurology and Neuroscience Reports. 9: 254-62. PMID 19348715 DOI: 10.1007/S11910-009-0037-2  0.366
2009 Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer. Nature Reviews. Clinical Oncology. 6: 229-36. PMID 19333229 DOI: 10.1038/Nrclinonc.2009.14  0.393
2009 Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 2542-52. PMID 19332720 DOI: 10.1200/Jco.2008.19.9356  0.331
2009 Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Research. 69: 2801-8. PMID 19318557 DOI: 10.1158/0008-5472.Can-08-4051  0.347
2009 Mok W, Stylianopoulos T, Boucher Y, Jain RK. Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2352-60. PMID 19318482 DOI: 10.1158/1078-0432.Ccr-08-2082  0.336
2009 Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, ... ... Jain RK, et al. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro-Oncology. 11: 853-60. PMID 19293394 DOI: 10.1215/15228517-2009-010  0.309
2009 Perentes JY, Duda DG, Jain RK. Visualizing anti-tumor immune responses in vivo. Disease Models & Mechanisms. 2: 107-10. PMID 19259379 DOI: 10.1242/Dmm.001842  0.38
2009 Cheng G, Tse J, Jain RK, Munn LL. Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. Plos One. 4: e4632. PMID 19247489 DOI: 10.1371/Journal.Pone.0004632  0.343
2009 Pieters A, Duda D, Steller E, Fukumura D, Jain R. The Role of Stromal Cells in Tumor Metastases. Cancer Research. 69: 6151-6151. DOI: 10.1158/0008-5472.Sabcs-09-6151  0.38
2009 Duyverman A, Duda DG, Steller EJA, Fukumura D, Jain RK. Abstract C57: The role of stromal cells in tumor metastases Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-C57  0.388
2008 Duda DG, Cohen KS, Ancukiewicz M, di Tomaso E, Zhu AX, Penson RT, Horowitz NS, Batchelor TT, Willett CG, Jain RK. A comparative study of circulating endothelial cells (CECs) and circulating progenitor cells (CPCs) kinetics in four multidisciplinary phase II studies of antiangiogenic agents. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3544. PMID 27949773 DOI: 10.1200/Jco.2008.26.15_Suppl.3544  0.3
2008 Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas. Current Opinion in Neurology. 21: 728-735. PMID 18989120 DOI: 10.1097/Wco.0B013E328318402A  0.365
2008 Fukumura D, Jain RK. Imaging angiogenesis and the microenvironment. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 116: 695-715. PMID 18834413 DOI: 10.1111/J.1600-0463.2008.01148.X  0.421
2008 Sorensen AG, Batchelor TT, Wen PY, Zhang W, Jain RK. Response criteria for glioma. Nature Reviews Clinical Oncology. 5: 634-644. PMID 18711427 DOI: 10.1038/Ncponc1204  0.303
2008 Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Molecular Cancer Therapeutics. 7: 2272-9. PMID 18687659 DOI: 10.1158/1535-7163.Mct-08-0182  0.379
2008 Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Research. 68: 3795-802. PMID 18483263 DOI: 10.1158/0008-5472.Can-07-6193  0.373
2008 Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nature Medicine. 14: 255-7. PMID 18278052 DOI: 10.1038/Nm1730  0.39
2008 Jain RK. Taming vessels to treat cancer Scientific American. 298: 56-63. PMID 18225696 DOI: 10.1038/Scientificamerican0108-56  0.383
2008 Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT. Antiangiogenic agents for the treatment of glioblastoma. Expert Opinion On Investigational Drugs. 16: 1895-908. PMID 18041999 DOI: 10.1517/13543784.16.12.1895  0.318
2008 Zuniga RM, Torcuator R, Doyle T, Anderson J, Jain R, Orley J, Rosenblum M, Mikkelsen T. Retrospective analysis of patterns of recurrence seen on MRI in patients with recurrent glioblastoma multiforme treated with bevacizumab plus irinotecan Journal of Clinical Oncology. 26: 13013-13013. DOI: 10.1200/Jco.2008.26.15_Suppl.13013  0.322
2007 Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia (New York, N.Y.). 9: 1038-45. PMID 18084611 DOI: 10.1593/Neo.07643  0.323
2007 Mok W, Boucher Y, Jain RK. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Research. 67: 10664-8. PMID 18006807 DOI: 10.1158/0008-5472.Can-07-3107  0.358
2007 Jain RK, Xu L. alphaPlGF: a new kid on the antiangiogenesis block. Cell. 131: 443-5. PMID 17981110 DOI: 10.1016/J.Cell.2007.10.023  0.348
2007 Sun C, Jain RK, Munn LL. Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion. Annals of Biomedical Engineering. 35: 2121-9. PMID 17846892 DOI: 10.1007/S10439-007-9377-8  0.364
2007 Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R. Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization. Nature Clinical Practice. Cardiovascular Medicine. 4: 491-502. PMID 17712362 DOI: 10.1038/Ncpcardio0979  0.327
2007 Xu L, Jain RK. Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma. Molecular Cancer Research : McR. 5: 873-80. PMID 17704140 DOI: 10.1158/1541-7786.Mcr-06-0141  0.332
2007 Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nature Reviews. Neuroscience. 8: 610-22. PMID 17643088 DOI: 10.1038/Nrn2175  0.326
2007 Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvascular Research. 74: 72-84. PMID 17560615 DOI: 10.1016/J.Mvr.2007.05.003  0.422
2007 Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Research. 67: 5076-82. PMID 17545583 DOI: 10.1158/0008-5472.Can-06-3664  0.417
2007 Bockhorn M, Jain RK, Munn LL. Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? The Lancet. Oncology. 8: 444-8. PMID 17466902 DOI: 10.1016/S1470-2045(07)70140-7  0.301
2007 Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, ... ... Jain RK, et al. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nature Clinical Practice. Oncology. 4: 316-21. PMID 17464339 DOI: 10.1038/Ncponc0813  0.303
2007 Duda DG, Batchelor TT, Willett CG, Jain RK. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends in Molecular Medicine. 13: 223-230. PMID 17462954 DOI: 10.1016/J.Molmed.2007.04.001  0.319
2007 Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Research. 67: 2729-35. PMID 17363594 DOI: 10.1158/0008-5472.Can-06-4102  0.426
2007 Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. Journal of the Society For Integrative Oncology. 5: 11-7. PMID 17309809 DOI: 10.2310/7200.2006.033  0.387
2007 Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, ... ... Jain RK, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 11: 83-95. PMID 17222792 DOI: 10.1016/J.Ccr.2006.11.021  0.404
2007 Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. Journal of Cellular Biochemistry. 101: 937-49. PMID 17171643 DOI: 10.1002/Jcb.21187  0.431
2007 Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Research. 66: 8065-75. PMID 16912183 DOI: 10.1158/0008-5472.Can-06-1392  0.335
2007 Ditomaso E, Stemmer-Rachamimov A, Potts A, Drottar M, Jain RK, Plotkin SR. Correlation between VEGF expression and MVD in sporadic and NF2-related schwannomas Journal of Clinical Oncology. 25: 2083-2083. DOI: 10.1200/Jco.2007.25.18_Suppl.2083  0.353
2007 Batchelor T, Sorensen AG, Ancukiewicz M, Duda DG, Louis DN, Plotkin SR, Ivy P, Wen PY, Loeffler JS, Jain R. A phase II trial of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma Journal of Clinical Oncology. 25: 2001-2001. DOI: 10.1200/Jco.2007.25.18_Suppl.2001  0.315
2007 Batchelor T, Duda D, di Tomaso E, Kozak K, Zhang W, Ancukiewicz M, Loeffler J, Wen P, Sorensen G, Jain R. Normalization of Tumor Vasculature and Alleviation of Edema by AZD2171, A Pan-VEGF Receptor Tyrosine Kinase Inhibitor in Glioblastoma Patients International Journal of Radiation Oncology*Biology*Physics. 69: S50-S51. DOI: 10.1016/J.Ijrobp.2007.07.092  0.33
2007 Willett CG, Duda DG, Jain RK. Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer Current Colorectal Cancer Reports. 3: 94-98. DOI: 10.1007/S11888-007-0007-5  0.403
2006 Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Seminars in Oncology. 33: S35-40. PMID 17145523 DOI: 10.1053/J.Seminoncol.2006.08.007  0.391
2006 Reddy ST, Berk DA, Jain RK, Swartz MA. A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 1162-9. PMID 16763103 DOI: 10.1152/Japplphysiol.00389.2006  0.426
2006 Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Research. 66: 3971-7. PMID 16618713 DOI: 10.1158/0008-5472.Can-04-3085  0.402
2006 Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Research. 66: 3360-4. PMID 16585153 DOI: 10.1158/0008-5472.Can-05-2655  0.317
2006 Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK. Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 1449-53. PMID 16549839 DOI: 10.1200/Jco.2005.04.2861  0.306
2006 McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Research. 66: 2509-13. PMID 16510565 DOI: 10.1158/0008-5472.Can-05-2242  0.353
2006 Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nature Clinical Practice. Oncology. 3: 24-40. PMID 16407877 DOI: 10.1038/Ncponc0403  0.359
2006 Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 107: 2774-6. PMID 16339405 DOI: 10.1182/Blood-2005-08-3210  0.364
2006 Nagano S, Perentes JY, Jain RK, Boucher Y. 45. Paclitaxel-TRAIL Enhances the Distribution of Oncolytic Herpes Simplex Virus-1 in a Human Mammary Carcinoma Xenograft Molecular Therapy. 13: S19. DOI: 10.1016/J.Ymthe.2006.08.059  0.386
2005 Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, ... ... Jain RK, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. 8: 131-41. PMID 16098466 DOI: 10.1016/J.Ccr.2005.07.003  0.336
2005 di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Research. 65: 5740-9. PMID 15994949 DOI: 10.1158/0008-5472.Can-04-4552  0.338
2005 Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Research. 65: 5674-82. PMID 15994941 DOI: 10.1158/0008-5472.Can-04-1682  0.314
2005 Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. The Journal of Clinical Investigation. 115: 1816-27. PMID 15951843 DOI: 10.1172/Jci24015  0.312
2005 Jain RK. Antiangiogenic therapy for cancer: current and emerging concepts Oncology (Williston Park, N.Y.). 19: 7-16. PMID 15934498  0.307
2005 Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nature Medicine. 11: 678-82. PMID 15880117 DOI: 10.1038/Nm1247  0.362
2005 Duda DG, Jain RK. Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow. The Journal of Clinical Investigation. 115: 596-8. PMID 15765145 DOI: 10.1172/Jci24511  0.301
2005 Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy Science. 307: 58-62. PMID 15637262 DOI: 10.1126/Science.1104819  0.415
2005 Grandi P, McKee TD, Mok W, Fernandez JL, Breakefield XO, Jain RK. 76. New Strategy To Improve Imaging and Retargeting of HSV-1 Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.054  0.303
2004 Willett CG, Chung D, Sahani D, Mino M, Clark J, Ryan D, Zhu A, Blaszkowski L, Lauwers G, Jain R. Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3589. PMID 28016318 DOI: 10.1200/Jco.2004.22.90140.3589  0.321
2004 Lawenda BD, Smith DE, Niemierko A, Xu L, Silverstein JR, Held KD, Loeffler JS, Jain RK, Blumberg JB. Radiomodifying responses of vitamin E and epigallocatechin gallate supplementation during irradiation of implanted tumors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 9601. PMID 28016194 DOI: 10.1200/Jco.2004.22.14_Suppl.9601  0.315
2004 Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 6: 553-63. PMID 15607960 DOI: 10.1016/J.Ccr.2004.10.011  0.376
2004 Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Research. 64: 5920-4. PMID 15342367 DOI: 10.1158/0008-5472.Can-04-1268  0.367
2004 Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Research. 64: 4400-4. PMID 15231646 DOI: 10.1158/0008-5472.Can-04-0752  0.348
2004 Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Research. 64: 3731-6. PMID 15172975 DOI: 10.1158/0008-5472.Can-04-0074  0.385
2004 Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvascular Research. 67: 231-6. PMID 15121448 DOI: 10.1016/J.Mvr.2004.02.001  0.336
2004 Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL. Differential gene expression in metastasizing cells shed from kidney tumors. Cancer Research. 64: 2469-73. PMID 15059900 DOI: 10.1158/0008-5472.Can-03-0256  0.372
2004 Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Pathology: cancer cells compress intratumour vessels. Nature. 427: 695. PMID 14973470 DOI: 10.1038/427695A  0.33
2004 Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, ... ... Jain RK, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Medicine. 10: 145-7. PMID 14745444 DOI: 10.1038/Nm988  0.368
2004 Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nature Medicine. 10: 203-7. PMID 14716306 DOI: 10.1038/Nm981  0.363
2004 Jain RK, Duda DG. Role of bone marrow-derived cells in tumor angiogenesis and treatment. Cancer Cell. 3: 515-6. PMID 12842078 DOI: 10.1016/S1535-6108(03)00138-7  0.367
2004 Gohongi T, Todoroki T, Fukumura D, Jain RK. Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site Oncology Reports. 11: 803-807. DOI: 10.3892/Or.11.4.803  0.365
2004 Jain RK. Reply to 'Recognition of tumor blood vessel normalization as a new antiangiogenic concept' Nature Medicine. 10: 329-330. DOI: 10.1038/Nm0404-329B  0.35
2004 Tyrrell JA, Mahadevan V, Tong R, Roysam B, Brown EB, Jain RK. Robust parametric modeling for improved segmentation of complex tumor microvasculature from multiphoton microscopy data Microscopy and Microanalysis. 10: 176-177. DOI: 10.1017/S1431927604885787  0.324
2003 Roose T, Netti PA, Munn LL, Boucher Y, Jain RK. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvascular Research. 66: 204-12. PMID 14609526 DOI: 10.1016/S0026-2862(03)00057-8  0.388
2003 Jain RK, Booth MF. What brings pericytes to tumor vessels? The Journal of Clinical Investigation. 112: 1134-6. PMID 14561696 DOI: 10.1172/Jci20087  0.32
2003 Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circulation Research. 93: e88-97. PMID 14525808 DOI: 10.1161/01.Res.0000099243.20096.Fa  0.308
2003 Jain RK. Molecular regulation of vessel maturation Nature Medicine. 9: 685-693. PMID 12778167 DOI: 10.1038/Nm0603-685  0.337
2003 Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK. A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood. 102: 2555-61. PMID 12775571 DOI: 10.1182/Blood-2003-02-0365  0.403
2003 Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nature Medicine. 9: 796-800. PMID 12754503 DOI: 10.1038/Nm879  0.367
2003 Mollica F, Jain RK, Netti PA. A model for temporal heterogeneities of tumor blood flow. Microvascular Research. 65: 56-60. PMID 12535873 DOI: 10.1016/S0026-2862(02)00012-2  0.388
2003 Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK. Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model. Neoplasia (New York, N.Y.). 4: 449-63. PMID 12192604 DOI: 10.1038/Sj.Neo.7900260  0.388
2003 Abdul-Karim MA, Al-Kofahi O, Brown EB, Jain RK, Al-Kofahi K, Roysam B. Automated in vivo change analysis of tumor vasculature from two-photon confocal image time series Proceedings of Spie - the International Society For Optical Engineering. 4963: 151-159. DOI: 10.1117/12.477991  0.329
2002 Padera TP, Stoll BR, So PT, Jain RK. Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions. Molecular Imaging. 1: 9-15. PMID 12920856 DOI: 10.1162/153535002753395662  0.312
2002 Jain RK. Angiogenesis and lymphangiogenesis in tumors: Insights from intravital microscopy Cold Spring Harbor Symposia On Quantitative Biology. 67: 239-248. PMID 12858546 DOI: 10.1101/Sqb.2002.67.239  0.389
2002 Jain RK. Tumor angiogenesis and accessibility: role of vascular endothelial growth factor Seminars in Oncology. 29: 3-9. PMID 12516032 DOI: 10.1016/S0093-7754(02)70063-8  0.42
2002 Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophysical Journal. 83: 1650-60. PMID 12202388 DOI: 10.1016/S0006-3495(02)73933-7  0.329
2002 Jain RK, Padera TP. Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy. Journal of the National Cancer Institute. 94: 785-7. PMID 12048260 DOI: 10.1093/Jnci/94.11.785  0.392
2002 Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science (New York, N.Y.). 296: 1883-6. PMID 11976409 DOI: 10.1126/Science.1071420  0.388
2002 Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK. Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia (New York, N.Y.). 4: 3-8. PMID 11922388 DOI: 10.1038/Sj.Neo.7900209  0.386
2002 Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 416: 279-80. PMID 11907566 DOI: 10.1038/416279B  0.303
2002 Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. The American Journal of Pathology. 160: 985-1000. PMID 11891196 DOI: 10.1016/S0002-9440(10)64920-6  0.39
2002 Hartford A, Fukumura D, Jain R. Systemic levels of VEGF and endostatin are influenced by tumor, host, and treatment factors International Journal of Radiation Oncology*Biology*Physics. 54: 28. DOI: 10.1016/S0360-3016(02)03105-X  0.333
2001 Jain RK, Forbes NS. Can engineered bacteria help control cancer? Proceedings of the National Academy of Sciences of the United States of America. 98: 14748-50. PMID 11752416 DOI: 10.1073/Pnas.261606598  0.393
2001 Tsuzuki Y, Carreira CM, Bockhorn M, Xu L, Jain RK, Fukumura D. Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation Laboratory Investigation. 81: 1439-1451. PMID 11598156 DOI: 10.1038/Labinvest.3780357  0.421
2001 Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LL. Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation. Circulation Research. 89: 732-9. PMID 11597997 DOI: 10.1161/Hh2001.097872  0.385
2001 Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy Nature Medicine. 7: 987-989. PMID 11533692 DOI: 10.1038/Nm0901-987  0.372
2001 Jain RK. Delivery of molecular medicine to solid tumors: Lessons from in vivo imaging of gene expression and function Journal of Controlled Release. 74: 7-25. PMID 11489479 DOI: 10.1016/S0168-3659(01)00306-6  0.409
2001 Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Medicine. 7: 864-8. PMID 11433354 DOI: 10.1038/89997  0.379
2001 Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA. A potential murine model for flap-related investigations. Plastic and Reconstructive Surgery. 107: 1504-8. PMID 11335827 DOI: 10.1097/00006534-200105000-00032  0.391
2001 Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 4628-33. PMID 11274375 DOI: 10.1073/Pnas.081626898  0.38
2001 Jain RK. Delivery of molecular and cellular medicine to solid tumors. Advanced Drug Delivery Reviews. 46: 149-68. PMID 11259838 DOI: 10.1016/S0169-409X(00)00131-9  0.416
2001 Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proceedings of the National Academy of Sciences of the United States of America. 97: 14608-13. PMID 11121063 DOI: 10.1073/Pnas.97.26.14608  0.397
2001 Hartford A, Gohongi T, Fukumura D, Jain R. Primary tumor irradiation affects levels of systemic angiogenic agents: potential roles for both tumor and host tissues International Journal of Radiation Oncology*Biology*Physics. 51: 190-191. DOI: 10.1016/S0360-3016(01)02169-1  0.369
2001 Tsuzuki Y, Fukumura D, Jain RK. Tumor-host interaction modulates production of antiangiogenic factors from human pancreatic cancer Gastroenterology. 120: A4-A5. DOI: 10.1016/S0016-5085(08)80022-4  0.328
2000 Kristensen CA, Hamberg LM, Hunter GJ, Roberge S, Kierstead D, Wolf GL, Jain RK. Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy. Neoplasia (New York, N.Y.). 1: 518-25. PMID 10935499 DOI: 10.1038/Sj.Neo.7900063  0.372
2000 Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM. Openings between defective endothelial cells explain tumor vessel leakiness. The American Journal of Pathology. 156: 1363-80. PMID 10751361 DOI: 10.1016/S0002-9440(10)65006-7  0.407
2000 McDonald DM, Munn L, Jain RK. Vasculogenic mimicry: how convincing, how novel, and how significant? The American Journal of Pathology. 156: 383-8. PMID 10666365 DOI: 10.1016/S0002-9440(10)64740-2  0.346
2000 Huang B, Jain RK, Locke RD, Alderfer JL, Tabaczynski WA, Matta KL. First total synthesis of sialylated and sulfated Lewisx mucin Core 2 structures as potential tumor associated antigens Tetrahedron Letters. 41: 6279-6284. DOI: 10.1016/S0040-4039(00)00975-8  0.318
2000 Tsuzuki Y, Fukumura D, Koike C, Jain RK. The orthotopic microenvironment promotes tumor growth and VEGF121 expression in human pancreatic adenocarcinoma Gastroenterology. 118: A1415. DOI: 10.1016/S0016-5085(00)81547-4  0.356
1999 Chandrasekaran EV, Jain RK, Rhodes JM, Chawda R, Piskorz C, Matta KL. Characterization of distinct Gal:3-O-sulfotransferase activities in human tumor epithelial cell lines and of calf lymph node GlcNAc : 6-O-sulfotransferase activity. Glycoconjugate Journal. 16: 523-36. PMID 10815989 DOI: 10.1023/A:1007074005371  0.327
1999 Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK. Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation. Journal of Biomechanics. 32: 1297-307. PMID 10569708 DOI: 10.1016/S0021-9290(99)00125-6  0.576
1999 Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nature Medicine. 5: 1203-8. PMID 10502827 DOI: 10.1038/13524  0.388
1999 Endo M, Jain RK, Witwer B, Brown D. Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas. Microvascular Research. 58: 89-98. PMID 10458924 DOI: 10.1006/Mvre.1999.2158  0.352
1999 Lichtenbeld HC, Ferarra N, Jain RK, Munn LL. Effect of local anti-VEGF antibody treatment on tumor microvessel permeability. Microvascular Research. 57: 357-62. PMID 10329263 DOI: 10.1006/Mvre.1998.2140  0.393
1999 Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proceedings of the National Academy of Sciences of the United States of America. 96: 3137-42. PMID 10077650 DOI: 10.1073/Pnas.96.6.3137  0.406
1999 Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK. Return of lymphatic function after flap transfer for acute lymphedema. Annals of Surgery. 229: 421-7. PMID 10077056 DOI: 10.1097/00000658-199903000-00017  0.398
1998 Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B. Tumor induction of VEGF promoter activity in stromal cells. Cell. 94: 715-25. PMID 9753319 DOI: 10.1016/S0092-8674(00)81731-6  0.396
1998 Jain RK. Delivery of molecular and cellular medicine to solid tumors Journal of Controlled Release. 53: 49-67. PMID 9741913 DOI: 10.1016/S0168-3659(97)00237-X  0.395
1998 Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proceedings of the National Academy of Sciences of the United States of America. 95: 10820-5. PMID 9724788 DOI: 10.1073/Pnas.95.18.10820  0.41
1998 Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. The Journal of Investigative Dermatology. 111: 1-6. PMID 9665379 DOI: 10.1046/J.1523-1747.1998.00262.X  0.308
1998 Fukumura D, Jain RK. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Reviews. 17: 77-89. PMID 9544424 DOI: 10.1023/A:1005908805527  0.408
1998 Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 95: 4607-12. PMID 9539785 DOI: 10.1073/Pnas.95.8.4607  0.578
1998 Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK. Fractal characteristics of tumor vascular architecture during tumor growth and regression. Microcirculation (New York, N.Y. : 1994). 4: 395-402. PMID 9431507 DOI: 10.3109/10739689709146803  0.385
1998 Hartford AC, Gohongi T, Fukumura D, Jain RK. Irradiation of a primary tumor enhances inhibition of angiogenesis induced at a secondary site International Journal of Radiation Oncology*Biology*Physics. 42: 169. DOI: 10.1016/S0360-3016(98)80191-0  0.344
1997 Griffon-Etienne G, Boucher Y, Jain RK, Suit HD. Effects of needle insertion in tumors on interstitial fluid pressure. Microvascular Research. 54: 174-7. PMID 9327388 DOI: 10.1006/Mvre.1997.2037  0.319
1997 Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CC, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, et al. Interlaboratory variation in oxygen tension measurement by Eppendorf 'Histograph' and comparison with hypoxic marker Journal of Surgical Oncology. 66: 30-38. PMID 9290690 DOI: 10.1002/(Sici)1096-9098(199709)66:1<30::Aid-Jso7>3.0.Co;2-O  0.331
1997 Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK. Solid stress inhibits the growth of multicellular tumor spheroids. Nature Biotechnology. 15: 778-83. PMID 9255794 DOI: 10.1038/Nbt0897-778  0.392
1997 Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (New York, N.Y.). 276: 1423-5. PMID 9162011 DOI: 10.1126/Science.276.5317.1423  0.439
1997 Baish JW, Netti PA, Jain RK. Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. Microvascular Research. 53: 128-41. PMID 9143544 DOI: 10.1006/Mvre.1996.2005  0.367
1997 Jain RK. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors Microcirculation (New York, N.Y. : 1994). 4: 1-23. PMID 9110280 DOI: 10.3109/10739689709148314  0.414
1997 Berk DA, Yuan F, Leunig M, Jain RK. Direct in vivo measurement of targeted binding in a human tumor xenograft. Proceedings of the National Academy of Sciences of the United States of America. 94: 1785-90. PMID 9050856 DOI: 10.1073/Pnas.94.5.1785  0.302
1997 Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Medicine. 3: 177-82. PMID 9018236 DOI: 10.1038/Nm0297-177  0.33
1997 Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvascular Research. 51: 327-46. PMID 8992232 DOI: 10.1006/Mvre.1996.0031  0.39
1997 Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proceedings of the National Academy of Sciences of the United States of America. 93: 14765-70. PMID 8962129 DOI: 10.1073/Pnas.93.25.14765  0.387
1997 Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors Aiche Journal. 43: 818-833. DOI: 10.1002/Aic.690430327  0.306
1996 Nozue M, Lee I, Hartford A, Tanda S, Suit H, Jain R. pO(2) measurement in murine tumors by Eppendorf 'Histograph'. International Journal of Oncology. 9: 955-962. PMID 21541601 DOI: 10.3892/Ijo.9.5.955  0.334
1996 Lichtenbeld HC, Yuan F, Michel CC, Jain RK. Perfusion of single tumor microvessels: application to vascular permeability measurement. Microcirculation (New York, N.Y. : 1994). 3: 349-57. PMID 9086446 DOI: 10.3109/10739689609148307  0.377
1996 Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Reviews. 15: 195-204. PMID 8842491 DOI: 10.1007/Bf00437472  0.38
1996 Jain RK. 1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors Annals of Biomedical Engineering. 24: 457-473. PMID 8841721 DOI: 10.1007/Bf02648108  0.414
1996 Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvascular Research. 52: 27-46. PMID 8812751 DOI: 10.1006/Mvre.1996.0041  0.336
1996 Munn LL, Melder RJ, Jain RK. Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation. Biophysical Journal. 71: 466-78. PMID 8804629 DOI: 10.1016/S0006-3495(96)79248-2  0.301
1996 Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Medicine. 2: 992-7. PMID 8782456 DOI: 10.1038/Nm0996-992  0.356
1996 Patan S, Munn LL, Jain RK. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvascular Research. 51: 260-72. PMID 8778579 DOI: 10.1006/Mvre.1996.0025  0.387
1996 Berk DA, Swartz MA, Leu AJ, Jain RK. Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. The American Journal of Physiology. 270: H330-7. PMID 8769769 DOI: 10.1152/Ajpheart.1996.270.1.H330  0.402
1996 Swartz MA, Berk DA, Jain RK. Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory. The American Journal of Physiology. 270: H324-9. PMID 8769768 DOI: 10.1152/Ajpheart.1996.270.1.H324  0.418
1996 Nozue M, Lee I, Manning JM, Manning LR, Jain RK. Oxygenation in tumors by modified hemoglobins. Journal of Surgical Oncology. 62: 109-14. PMID 8649036 DOI: 10.1002/(Sici)1096-9098(199606)62:2<109::Aid-Jso6>3.0.Co;2-C  0.319
1996 Jain RK. Delivery of molecular medicine to solid tumors Science. 271: 1079-1080. PMID 8599082 DOI: 10.1126/Science.271.5252.1079  0.38
1996 Zlotecki RA, Baxter LT, Boucher Y, Jain RK. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation. Microvascular Research. 50: 429-43. PMID 8583955 DOI: 10.1006/Mvre.1995.1069  0.366
1996 Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK. Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. Biophysical Journal. 69: 2131-8. PMID 8580357 DOI: 10.1016/S0006-3495(95)80087-1  0.306
1996 Boucher Y, Lee I, Jain RK. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors. Microvascular Research. 50: 175-82. PMID 8538498 DOI: 10.1006/Mvre.1995.1051  0.378
1995 Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvascular Research. 48: 1-12. PMID 7990716 DOI: 10.1006/Mvre.1994.1034  0.312
1995 Kristjansen PE, Roberge S, Lee I, Jain RK. Tissue-isolated human tumor xenografts in athymic nude mice. Microvascular Research. 48: 389-402. PMID 7731400 DOI: 10.1006/Mvre.1994.1063  0.389
1995 Melder RJ, Salehi HA, Jain RK. Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice. Microvascular Research. 50: 35-44. PMID 7476578 DOI: 10.1006/Mvre.1995.1036  0.387
1995 Taghian A, Huang P, Allarn A, Perez L, Boucher Y, Lee I, Duffy M, Azinovic L, Jain R, Suit H. 1054 The correlation between fractionated TCD50 and different predictive radiobiologic parameters of nine human tumor xenografts into nude mice International Journal of Radiation Oncology*Biology*Physics. 32: 250. DOI: 10.1016/0360-3016(95)97879-6  0.318
1995 SWARTZ M, BERK D, LEU A, JAIN R. Macromolecular transport in the initial lymphatics: Characterization using RTD theory and FRAP Biorheology. 32: 351-351. DOI: 10.1016/0006-355X(95)92338-B  0.385
1995 NETTI P, BAXTER L, COUCHER Y, SKALAK R, JAIN R. A poroelastic model for interstitial pressure in tumors Biorheology. 32: 346-346. DOI: 10.1016/0006-355X(95)92330-D  0.331
1995 HELMLINGER G, NETTI P, LICHTENBELD H, MELDER R, JAIN R. Inhibition of tumor growth by solid stress Biorheology. 32: 345-346. DOI: 10.1016/0006-355X(95)92329-9  0.346
1995 GAZIT Y, PATAN S, BERK D, LEUNIG M, MUNN L, BAXTER L, JAIN R. S1.2. New insights into the structure of tumor vasculature: From fractal dimensions to intussusception Biorheology. 32: 112-112. DOI: 10.1016/0006-355X(95)91954-2  0.327
1994 Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK. Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement. Journal of the National Cancer Institute. 86: 293-9. PMID 8158684 DOI: 10.1093/Jnci/86.4.293  0.372
1994 Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 2081-5. PMID 8134352 DOI: 10.1073/Pnas.91.6.2081  0.372
1994 Jain RK. Barriers to drug delivery in solid tumors Scientific American. 271: 58-65. PMID 8066425 DOI: 10.1038/Scientificamerican0794-58  0.346
1994 Melder RJ, Jain RK. Reduction of rigidity in human activated natural killer cells by thioglycollate treatment Journal of Immunological Methods. 175: 69-77. PMID 7930640 DOI: 10.1016/0022-1759(94)90332-8  0.302
1994 Jain RK. INTERSTITIAL TRANSPORT IN TUMORS ROLE OF BINDING Journal of Immunotherapy. 16: 150. DOI: 10.1097/00002371-199408000-00018  0.318
1994 Jain RK. Transport Phenomena in Tumors Advances in Chemical Engineering. 19: 129-200. DOI: 10.1016/S0065-2377(08)60214-8  0.338
1993 Eskey CJ, Koretsky AP, Domach MM, Jain RK. Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR. Proceedings of the National Academy of Sciences of the United States of America. 90: 2646-50. PMID 8464871 DOI: 10.1073/Pnas.90.7.2646  0.348
1993 Yuan F, Leunig M, Berk DA, Jain RK. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvascular Research. 45: 269-89. PMID 8321142 DOI: 10.1006/Mvre.1993.1024  0.359
1993 Lee I, Gerweck LE, Boucher Y, Demhartner TJ, Mendello C, Jain RK. Improved physiological parameters in murine & human tumors by nicotinamide International Journal of Radiation Oncology*Biology*Physics. 27: 305. DOI: 10.1016/0360-3016(93)90921-H  0.338
1992 Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular network architecture in a mammary carcinoma. Exs. 61: 74-80. PMID 1377578 DOI: 10.1007/978-3-0348-7001-6_13  0.373
1992 Zlotecki R, Boucher Y, Lee I, Jain R. Effect of angiotensin ii induced hypertension on tumor interstitial fluid pressure and tumor blood flow International Journal of Radiation Oncology*Biology*Physics. 24: 310. DOI: 10.1016/0360-3016(92)90442-K  0.341
1992 Lee I, Demhartner T, Boucher Y, Jain RK. Decrease in tumor interstitial fluid pressure by pentoxifylline International Journal of Radiation Oncology*Biology*Physics. 24: 307. DOI: 10.1016/0360-3016(92)90437-M  0.323
1992 Zanti C, Roh H, Boucher Y, King G, Kalnicki S, Buchsbaum R, Bloomer W, Jain R. Use of radiation on interstitial fluid pressure (IFP) and pO2 in human tumors International Journal of Radiation Oncology*Biology*Physics. 24: 306. DOI: 10.1016/0360-3016(92)90436-L  0.305
1992 Leunig M, Yuan F, Menger M, Goetz A, Messmer K, Jain R. A novel model to study microcirculation mediated mechanisms of radiotherapy in human tumor xenografts International Journal of Radiation Oncology*Biology*Physics. 24: 305-306. DOI: 10.1016/0360-3016(92)90435-K  0.368
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvascular Research. 40: 246-63. PMID 2250603 DOI: 10.1016/0026-2862(90)90023-K  0.382
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvascular Research. 41: 252-72. PMID 2051960 DOI: 10.1016/0026-2862(91)90026-8  0.355
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvascular Research. 41: 5-23. PMID 2051954 DOI: 10.1016/0026-2862(91)90003-T  0.324
1991 Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK. Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation. Journal of the National Cancer Institute. 83: 433-437. PMID 1999850 DOI: 10.1093/Jnci/83.6.433  0.393
1991 Jain RK. Therapeutic implications of tumor physiology Current Opinion in Oncology. 3: 1105-1108. PMID 1843113 DOI: 10.1097/00001622-199112000-00020  0.402
1991 Jain RK. Haemodynamic and transport barriers to the treatment of solid tumours. International Journal of Radiation Biology. 60: 85-100. PMID 1678003 DOI: 10.1080/09553009114551621  0.327
1990 Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors Cancer and Metastasis Review. 9: 253-266. PMID 2292138 DOI: 10.1007/Bf00046364  0.434
1990 Jain RK. Tumor physiology and antibody delivery Frontiers of Radiation Therapy and Oncology. 24: 32-46; discussion 64. PMID 2187763 DOI: 10.1159/000417767  0.348
1989 Jain RK. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies Journal of the National Cancer Institute. 81: 570-576. PMID 2649688 DOI: 10.1093/Jnci/81.8.570  0.365
1989 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvascular Research. 37: 77-104. PMID 2646512 DOI: 10.1016/0026-2862(89)90074-5  0.38
1988 Jain RK. Transvascular and interstitial transport in tumors Advances in Experimental Medicine and Biology. 242: 215-220. PMID 2469315 DOI: 10.1007/978-1-4684-8935-4_24  0.387
1987 Jain RK. Transport of molecules across tumor vasculature Cancer and Metastasis Review. 6: 559-593. PMID 3327633 DOI: 10.1007/Bf00047468  0.359
1986 Jain RK, Gerlowski LE. Extravascular transport in normal and tumor tissues. Critical Reviews in Oncology/Hematology. 5: 115-70. PMID 3521923 DOI: 10.1016/S1040-8428(86)80023-3  0.345
1986 Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissues. Microvascular Research. 31: 288-305. PMID 2423854 DOI: 10.1016/0026-2862(86)90018-X  0.335
1985 Jain RK. Transport of macromolecules in tumor microcirculation Biotechnology Progress™. 1: 81-94. DOI: 10.1002/Btpr.5420010205  0.355
1984 Jain RK, Ward-Hartley K. Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia Ieee Transactions On Sonics and Ultrasonics. 31: 504-525. DOI: 10.1109/T-Su.1984.31536  0.316
1983 Shah SA, Jain RK, Finney PL. Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma. Advances in Experimental Medicine and Biology. 157: 23-42. PMID 7158522 DOI: 10.1007/978-1-4684-4388-2_4  0.341
1983 Shah SA, Jain RK, Finney PL. Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma. Cancer Letters. 19: 317-23. PMID 6883314 DOI: 10.1016/0304-3835(83)90101-5  0.344
1983 Jain RK, Maldarelli C. STABILITY OF THIN VISCOELASTIC FILMS WITH APPLICATIONS TO BIOLOGICAL MEMBRANE DEFORMATION Annals of the New York Academy of Sciences. 404: 89-102. DOI: 10.1111/J.1749-6632.1983.Tb19435.X  0.692
1982 Gullino PM, Jain RK, Grantham FH. Temperature Gradients and Local Perfusion in a Mammary Carcinoma Journal of the National Cancer Institute. 68: 519-533. DOI: 10.1093/Jnci/68.3.519  0.341
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. II. Extension of the theory to the study of the onset of small-scale cell membrane motions Journal of Colloid and Interface Science. 90: 263-276. DOI: 10.1016/0021-9797(82)90418-0  0.699
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation Journal of Colloid and Interface Science. 90: 233-262. DOI: 10.1016/0021-9797(82)90417-9  0.675
1981 Jain RK, Weissbrod JM, Wei J. Mass transport in tumors: characterization and applications to chemotherapy. Advances in Cancer Research. 33: 251-310. PMID 7006335 DOI: 10.1016/S0065-230X(08)60672-7  0.358
1980 Maldarelli C, Jain RK, Ivanov IB, Ruckenstein E. Stability of symmetric and unsymmetric thin liquid films to short and long wavelength perturbations Journal of Colloid and Interface Science. 78: 118-143. DOI: 10.1016/0021-9797(80)90501-9  0.722
1979 Jain RK, Grantham FH, Gullino PM. Blood Flow and Heat Transfer in Walker 256 Mammary Carcinoma Journal of the National Cancer Institute. 62: 927-933. DOI: 10.1093/Jnci/62.4.927  0.325
1976 Jain RK, Ruckenstein E. Stability of stagnant viscous films on a solid surface Journal of Colloid and Interface Science. 54: 108-116. DOI: 10.1016/0021-9797(76)90290-3  0.482
1974 Ruckenstein E, Jain RK. Spontaneous rupture of thin liquid films Journal of the Chemical Society, Faraday Transactions 2. 70: 132. DOI: 10.1039/F29747000132  0.488
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