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Christian Vaisse, M.D., Ph.D. - Publications

Affiliations: 
Diabetes Center University of California, San Francisco, San Francisco, CA 
Area:
Genetics of Obesity
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW. Identification of AgRP cells in the murine hindbrain that drive feeding. Molecular Metabolism. 101886. PMID 38246589 DOI: 10.1016/j.molmet.2024.101886  0.484
2021 Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. The Journal of Clinical Investigation. 131. PMID 33938449 DOI: 10.1172/JCI142064  0.37
2020 Bernard AA, Naharros IO, Guglielmetti FB, Yue X, Vaisse C. OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1166  0.419
2019 Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nature Metabolism. 1: 475-484. PMID 31535083 DOI: 10.1038/s42255-019-0051-x  0.348
2018 Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science (New York, N.Y.). PMID 30545847 DOI: 10.1126/Science.Aau0629  0.5
2018 Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nature Genetics. PMID 29311635 DOI: 10.1038/S41588-017-0020-9  0.766
2017 Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Reports. 19: 2257-2271. PMID 28614713 DOI: 10.1016/J.Celrep.2017.05.060  0.503
2017 Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harbor Perspectives in Biology. PMID 28096262 DOI: 10.1101/Cshperspect.A028217  0.486
2014 Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. Plos One. 9: e96805. PMID 24820477 DOI: 10.1371/Journal.Pone.0096805  0.74
2014 Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, ... ... Vaisse C, et al. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring, Md.). 22: S1-S17. PMID 24574081 DOI: 10.1002/Oby.20646  0.378
2014 Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. Functional characterization of SIM1-associated enhancers. Human Molecular Genetics. 23: 1700-8. PMID 24203700 DOI: 10.1093/Hmg/Ddt559  0.482
2014 Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. International Journal of Obesity (2005). 38: 148-51. PMID 23649472 DOI: 10.1038/Ijo.2013.53  0.366
2012 Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nature Chemical Biology. 8: 725-30. PMID 22729149 DOI: 10.1038/Nchembio.1008  0.657
2011 Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring, Md.). 19: 2394-403. PMID 21512513 DOI: 10.1038/Oby.2011.79  0.42
2011 Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obesity Surgery. 21: 930-4. PMID 20957447 DOI: 10.1007/S11695-010-0295-8  0.766
2011 Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of the Usa. 22: 2283-93. PMID 20941479 DOI: 10.1007/S00198-010-1432-X  0.344
2011 Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. Bariatric surgery in a patient with complete MC4R deficiency. International Journal of Obesity (2005). 35: 457-61. PMID 20733581 DOI: 10.1038/Ijo.2010.168  0.687
2010 Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 46: 217-25. PMID 19853069 DOI: 10.1016/J.Bone.2009.10.015  0.352
2010 Swarbrick M, Evans D, Ascencio M, Favre H, Wu S, Njajou O, Li R, Zmuda J, Miljkovic I, Harris T, Kwok P, Vaisse C, Hsueh W. Systematic examination of the SIM1 gene region: Replication and extension of association between common genetic variants and adiposity Obesity Research & Clinical Practice. 4: S10-S11. DOI: 10.1016/J.Orcp.2010.09.021  0.352
2009 Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. In silico mutagenesis: a case study of the melanocortin 4 receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3059-69. PMID 19417090 DOI: 10.1096/Fj.08-127530  0.376
2009 Calton MA, Vaisse C. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Medicine. 1: 31. PMID 19341502 DOI: 10.1186/Gm31  0.773
2009 Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clinical Endocrinology. 71: 388-93. PMID 19170711 DOI: 10.1111/J.1365-2265.2008.03513.X  0.686
2009 Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Human Molecular Genetics. 18: 1140-7. PMID 19091795 DOI: 10.1093/Hmg/Ddn431  0.757
2008 Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Endocrinology and Metabolism Clinics of North America. 37: 733-51, x. PMID 18775361 DOI: 10.1016/J.Ecl.2008.07.003  0.531
2008 Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. The Journal of Clinical Endocrinology and Metabolism. 93: 4955-62. PMID 18765507 DOI: 10.1210/Jc.2008-1164  0.477
2008 Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatric Research. 63: 211-6. PMID 18091355 DOI: 10.1203/Pdr.0B013E31815Ed62B  0.771
2007 Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. Plos One. 2: e668. PMID 17668051 DOI: 10.1371/Journal.Pone.0000668  0.322
2007 Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, et al. Medical sequencing at the extremes of human body mass. American Journal of Human Genetics. 80: 779-91. PMID 17357083 DOI: 10.1086/513471  0.755
2006 Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. The Journal of Clinical Endocrinology and Metabolism. 91: 1811-8. PMID 16507637 DOI: 10.1210/Jc.2005-1411  0.568
2005 Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, ... ... Vaisse C, et al. Lack of support for the association between GAD2 polymorphisms and severe human obesity. Plos Biology. 3: e315. PMID 16122350 DOI: 10.1371/Journal.Pbio.0030315  0.501
2005 Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 26: 1909-19. PMID 16083993 DOI: 10.1016/J.Peptides.2004.11.042  0.569
2005 Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. The Journal of Clinical Endocrinology and Metabolism. 90: 4446-51. PMID 15914531 DOI: 10.1210/Jc.2004-2545  0.318
2004 Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PAX4 gene variations predispose to ketosis-prone diabetes. Human Molecular Genetics. 13: 3151-9. PMID 15509590 DOI: 10.1093/Hmg/Ddh341  0.316
2004 Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. The Journal of Clinical Investigation. 114: 1158-64. PMID 15489963 DOI: 10.1172/Jci21927  0.474
2004 Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C. A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. The Journal of Clinical Endocrinology and Metabolism. 89: 2028-32. PMID 15126516 DOI: 10.1210/Jc.2003-031993  0.47
2003 Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C. The human MC4R promoter: characterization and role in obesity. Diabetes. 52: 2996-3000. PMID 14633862 DOI: 10.2337/Diabetes.52.12.2996  0.546
2003 Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Annals of the New York Academy of Sciences. 994: 225-32. PMID 12851320 DOI: 10.1111/J.1749-6632.2003.Tb03184.X  0.329
2003 Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. Molecular genetics of human obesity-associated MC4R mutations. Annals of the New York Academy of Sciences. 994: 49-57. PMID 12851297 DOI: 10.1111/J.1749-6632.2003.Tb03161.X  0.581
2003 Swarbrick MM, Vaisse C. Emerging trends in the search for genetic variants predisposing to human obesity. Current Opinion in Clinical Nutrition and Metabolic Care. 6: 369-75. PMID 12806208 DOI: 10.1097/01.Mco.0000078997.96795.03  0.437
2003 Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Human Molecular Genetics. 12: 145-53. PMID 12499395 DOI: 10.1093/Hmg/Ddg016  0.575
2000 Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes. 49: 1347-52. PMID 10923636 DOI: 10.2337/Diabetes.49.8.1347  0.513
2000 Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. The Journal of Clinical Investigation. 106: 253-62. PMID 10903341 DOI: 10.1172/Jci9238  0.557
2000 Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. Human Heredity. 50: 370-81. PMID 10899756 DOI: 10.1159/000022943  0.346
2000 Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 24: 391-3. PMID 10757637 DOI: 10.1038/Sj.Ijo.0801191  0.502
1998 Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. The Journal of Clinical Endocrinology and Metabolism. 83: 4006-12. PMID 9814484 DOI: 10.1210/Jcem.83.11.5214  0.308
1998 Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics. 20: 113-4. PMID 9771699 DOI: 10.1038/2407  0.537
1998 Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392: 398-401. PMID 9537324 DOI: 10.1038/32911  0.553
1996 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics. 14: 95-7. PMID 8782827 DOI: 10.1038/Ng0996-95  0.604
1995 Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nature Genetics. 9: 299-304. PMID 7773293 DOI: 10.1038/Ng0395-299  0.41
1995 Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. The New England Journal of Medicine. 333: 352-4. PMID 7609752 DOI: 10.1056/Nejm199508103330605  0.513
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