Lawrence SB Goldstein, PhD - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
axonal transport

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Niederst ED, Reyna SM, Goldstein LS. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Molecular Biology of the Cell. 26: 205-17. PMID 25392299 DOI: 10.1091/mbc.E14-06-1049  0.344
2014 Neumann S, Campbell GE, Szpankowski L, Goldstein LS, Encalada SE. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis. Journal of Visualized Experiments : Jove. e52029. PMID 25406537 DOI: 10.3791/52029  0.804
2014 Encalada SE, Goldstein LS. Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Annual Review of Biophysics. 43: 141-69. PMID 24702007 DOI: 10.1146/Annurev-Biophys-051013-022746  0.782
2014 Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3320-39. PMID 24573290 DOI: 10.1523/Jneurosci.1503-13.2014  0.794
2014 Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL. Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. Journal of Cell Science. 127: 1537-49. PMID 24522182 DOI: 10.1242/Jcs.140780  0.779
2013 Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. The Journal of Biological Chemistry. 288: 35222-36. PMID 24145027 DOI: 10.1074/Jbc.M113.513705  0.575
2013 Duncan JE, Lytle NK, Zuniga A, Goldstein LS. The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila. Plos One. 8: e68324. PMID 23840848 DOI: 10.1371/journal.pone.0068324  0.412
2013 Gunawardena S, Yang G, Goldstein LS. Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. Human Molecular Genetics. 22: 3828-43. PMID 23710041 DOI: 10.1093/Hmg/Ddt237  0.444
2013 Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, ... ... Goldstein LS, et al. A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. Cell Stem Cell. 12: 316-28. PMID 23333150 DOI: 10.1016/J.Stem.2012.12.011  0.717
2013 Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS. Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Traffic (Copenhagen, Denmark). 14: 295-308. PMID 23279138 DOI: 10.1111/Tra.12037  0.822
2013 Jiang Q, Crews LA, Barrett CL, Chun HJ, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao KH, Morris SR, Goldstein LS, Marra MA, et al. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 110: 1041-6. PMID 23275297 DOI: 10.1073/Pnas.1213021110  0.722
2013 Jiang Q, Crews LA, Barrett CL, Court-Recart A, Goff D, Sadarangani A, Rusert J, Morris S, Goldstein L, Chun H, Marra M, Fraser K, Dao K, Minden M, Jamieson C. Abstract 247: ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. Cancer Research. 73: 247-247. DOI: 10.1158/1538-7445.Am2013-247  0.733
2012 Rodrigues EM, Weissmiller AM, Goldstein LS. Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects. Human Molecular Genetics. 21: 4587-601. PMID 22843498 DOI: 10.1093/Hmg/Dds297  0.704
2012 Szpankowski L, Encalada SE, Goldstein LS. Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles. Proceedings of the National Academy of Sciences of the United States of America. 109: 8582-7. PMID 22582169 DOI: 10.1073/Pnas.1120510109  0.826
2012 Goldstein LS. Axonal transport and neurodegenerative disease: can we see the elephant? Progress in Neurobiology. 99: 186-90. PMID 22484448 DOI: 10.1016/j.pneurobio.2012.03.006  0.385
2012 Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS. Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Molecular Biology of the Cell. 23: 1700-14. PMID 22398725 DOI: 10.1091/Mbc.E11-11-0938  0.824
2012 Killian RL, Flippin JD, Herrera CM, Almenar-Queralt A, Goldstein LS. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. Plos One. 7: e29755. PMID 22272245 DOI: 10.1371/Journal.Pone.0029755  0.785
2011 Henthorn KS, Roux MS, Herrera C, Goldstein LS. A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. Molecular Biology of the Cell. 22: 4038-46. PMID 21880894 DOI: 10.1091/mbc.E10-07-0572  0.387
2011 Israel MA, Goldstein LS. Capturing Alzheimer's disease genomes with induced pluripotent stem cells: prospects and challenges. Genome Medicine. 3: 49. PMID 21867573 DOI: 10.1186/Gm265  0.322
2011 Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, et al. Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. Plos One. 6: e17540. PMID 21407814 DOI: 10.1371/Journal.Pone.0017540  0.746
2011 Encalada SE, Szpankowski L, Xia CH, Goldstein LS. Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 144: 551-65. PMID 21335237 DOI: 10.1016/J.Cell.2011.01.021  0.814
2011 Goldstein L. S4-02-01: APP/tau interaction and axonal transport Alzheimer's & Dementia. 7: S676-S676. DOI: 10.1016/J.Jalz.2011.05.1948  0.449
2010 Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS. Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies. Human Molecular Genetics. 19: 4399-408. PMID 20817925 DOI: 10.1093/Hmg/Ddq363  0.823
2009 Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V. Sunday driver interacts with two distinct classes of axonal organelles. The Journal of Biological Chemistry. 284: 34628-39. PMID 19801628 DOI: 10.1074/Jbc.M109.035022  0.752
2009 Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiology of Disease. 36: 11-25. PMID 19497367 DOI: 10.1016/J.Nbd.2009.05.016  0.738
2009 Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS. Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5758-67. PMID 19420244 DOI: 10.1523/Jneurosci.0780-09.2009  0.823
2008 Her LS, Goldstein LS. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13662-72. PMID 19074039 DOI: 10.1523/JNEUROSCI.4144-08.2008  0.394
2008 Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Human Molecular Genetics. 17: 3474-86. PMID 18694898 DOI: 10.1093/Hmg/Ddn240  0.812
2007 Haghnia M, Cavalli V, Shah SB, Schimmelpfeng K, Brusch R, Yang G, Herrera C, Pilling A, Goldstein LS. Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment. Molecular Biology of the Cell. 18: 2081-9. PMID 17360970 DOI: 10.1091/Mbc.E06-08-0695  0.8
2006 Duncan JE, Goldstein LS. The genetics of axonal transport and axonal transport disorders. Plos Genetics. 2: e124. PMID 17009871 DOI: 10.1371/journal.pgen.0020124  0.359
2006 Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, ... ... Goldstein LS, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022  0.67
2006 Stokin GB, Goldstein LS. Axonal transport and Alzheimer's disease. Annual Review of Biochemistry. 75: 607-27. PMID 16756504 DOI: 10.1146/Annurev.Biochem.75.103004.142637  0.717
2006 Stokin GB, Goldstein LS. Linking molecular motors to Alzheimer's disease. Journal of Physiology, Paris. 99: 193-200. PMID 16459060 DOI: 10.1016/J.Jphysparis.2005.12.085  0.667
2006 Goldstein L. S5-02-05: Linking stem cells and molecular motors to signaling and neurodegenerative disease Alzheimer's & Dementia. 2: S92-S92. DOI: 10.1016/J.Jalz.2006.05.359  0.348
2005 Cavalli V, Kujala P, Klumperman J, Goldstein LS. Sunday Driver links axonal transport to damage signaling. The Journal of Cell Biology. 168: 775-87. PMID 15738268 DOI: 10.1083/jcb.200410136  0.644
2005 Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (New York, N.Y.). 307: 1282-8. PMID 15731448 DOI: 10.1126/Science.1105681  0.818
2005 Gunawardena S, Goldstein LS. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Archives of Neurology. 62: 46-51. PMID 15642849 DOI: 10.1001/archneur.62.1.46  0.309
2005 Stokin GB, Queralt-Almenar A, Goldstein LS. [P-077]: Identifying early changes in the pathogenesis of Alzheimer's disease with potential diagnostic and therapetic relevance Alzheimer's & Dementia. 1: S32-S32. DOI: 10.1016/j.jalz.2005.06.151  0.566
2004 Guzik BW, Goldstein LS. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Current Opinion in Cell Biology. 16: 443-50. PMID 15261678 DOI: 10.1016/j.ceb.2004.06.002  0.383
2004 Gunawardena S, Goldstein LS. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. Journal of Neurobiology. 58: 258-71. PMID 14704957 DOI: 10.1002/neu.10319  0.412
2003 Goldstein LS. Do disorders of movement cause movement disorders and dementia? Neuron. 40: 415-25. PMID 14556718 DOI: 10.1016/S0896-6273(03)00630-5  0.324
2003 Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, Goldstein LS. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron. 40: 25-40. PMID 14527431 DOI: 10.1016/S0896-6273(03)00594-4  0.385
2003 Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Developmental Cell. 4: 521-33. PMID 12689591 DOI: 10.1016/S1534-5807(03)00094-7  0.303
2003 Xia CH, Roberts EA, Her LS, Liu X, Williams DS, Cleveland DW, Goldstein LS. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. The Journal of Cell Biology. 161: 55-66. PMID 12682084 DOI: 10.1083/Jcb.200301026  0.586
2002 Ji JY, Haghnia M, Trusty C, Goldstein LS, Schubiger G. A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics. 162: 1179-95. PMID 12454065  0.763
2001 Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 414: 643-8. PMID 11740561 DOI: 10.1038/414643a  0.391
2001 Gunawardena S, Goldstein LS. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron. 32: 389-401. PMID 11709151 DOI: 10.1016/S0896-6273(01)00496-2  0.425
2001 Almenar-Queralt A, Goldstein LS. Linkers, packages and pathways: new concepts in axonal transport. Current Opinion in Neurobiology. 11: 550-7. PMID 11595487  0.414
2001 Yang Z, Roberts EA, Goldstein LS. Functional analysis of mouse kinesin motor Kif3C. Molecular and Cellular Biology. 21: 5306-11. PMID 11463814 DOI: 10.1128/MCB.21.16.5306-5311.2001  0.343
2001 Yang Z, Roberts EA, Goldstein LS. Functional analysis of mouse C-terminal kinesin motor KifC2. Molecular and Cellular Biology. 21: 2463-6. PMID 11259594 DOI: 10.1128/MCB.21.7.2463-2466.2001  0.417
2001 Yang Z, Xia Ch, Roberts EA, Bush K, Nigam SK, Goldstein LS. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Molecular and Cellular Biology. 21: 765-70. PMID 11154264 DOI: 10.1128/Mcb.21.3.765-770.2001  0.582
2000 Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28: 449-59. PMID 11144355 DOI: 10.1016/S0896-6273(00)00124-0  0.771
2000 Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell. 103: 583-94. PMID 11106729 DOI: 10.1016/S0092-8674(00)00162-8  0.418
2000 Kamal A, Goldstein LS. Connecting vesicle transport to the cytoskeleton. Current Opinion in Cell Biology. 12: 503-8. PMID 10873823 DOI: 10.1016/S0955-0674(00)00123-X  0.462
2000 Goldstein LS, Yang Z. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annual Review of Neuroscience. 23: 39-71. PMID 10845058 DOI: 10.1146/annurev.neuro.23.1.39  0.333
2000 Dubreuil RR, Wang P, Dahl S, Lee J, Goldstein LS. Drosophila beta spectrin functions independently of alpha spectrin to polarize the Na,K ATPase in epithelial cells. The Journal of Cell Biology. 149: 647-56. PMID 10791978 DOI: 10.1083/Jcb.149.3.647  0.669
2000 Marszalek JR, Goldstein LS. Understanding the functions of kinesin-II. Biochimica Et Biophysica Acta. 1496: 142-50. PMID 10722883 DOI: 10.1016/S0167-4889(00)00015-X  0.306
1999 Ray K, Perez SE, Yang Z, Xu J, Ritchings BW, Steller H, Goldstein LS. Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila. The Journal of Cell Biology. 147: 507-18. PMID 10545496 DOI: 10.1083/jcb.147.3.507  0.383
1999 Bowman AB, Patel-King RS, Benashski SE, McCaffery JM, Goldstein LS, King SM. Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. The Journal of Cell Biology. 146: 165-80. PMID 10402468 DOI: 10.1083/jcb.146.1.165  0.4
1999 Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LS. Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. The Journal of Cell Biology. 145: 469-79. PMID 10225949 DOI: 10.1083/jcb.145.3.469  0.375
1998 Xia Ch, Rahman A, Yang Z, Goldstein LS. Chromosomal localization reveals three kinesin heavy chain genes in mouse. Genomics. 52: 209-13. PMID 9782088 DOI: 10.1006/Geno.1998.5427  0.523
1998 Gindhart JG, Desai CJ, Beushausen S, Zinn K, Goldstein LS. Kinesin light chains are essential for axonal transport in Drosophila. The Journal of Cell Biology. 141: 443-54. PMID 9548722 DOI: 10.1083/Jcb.141.2.443  0.36
1998 Sakowicz R, Berdelis MS, Ray K, Blackburn CL, Hopmann C, Faulkner DJ, Goldstein LS. A marine natural product inhibitor of kinesin motors. Science (New York, N.Y.). 280: 292-5. PMID 9535660 DOI: 10.1126/Science.280.5361.292  0.317
1998 Yang Z, Goldstein LS. Characterization of the KIF3C neural kinesin-like motor from mouse. Molecular Biology of the Cell. 9: 249-61. PMID 9450952  0.344
1997 Hanlon DW, Yang Z, Goldstein LS. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Neuron. 18: 439-51. PMID 9115737  0.444
1997 Pereira AJ, Dalby B, Stewart RJ, Doxsey SJ, Goldstein LS. Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila. The Journal of Cell Biology. 136: 1081-90. PMID 9060472 DOI: 10.1083/Jcb.136.5.1081  0.306
1997 Lee JK, Brandin E, Branton D, Goldstein LS. alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster. Development (Cambridge, England). 124: 353-62. PMID 9053311  0.535
1996 Desai CJ, Gindhart JG, Goldstein LS, Zinn K. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell. 84: 599-609. PMID 8598046 DOI: 10.1016/S0092-8674(00)81035-1  0.336
1995 Deng H, Lee JK, Goldstein LS, Branton D. Drosophila development requires spectrin network formation. The Journal of Cell Biology. 128: 71-9. PMID 7822424 DOI: 10.1083/Jcb.128.1.71  0.593
1994 Pesavento PA, Stewart RJ, Goldstein LS. Characterization of the KLP68D kinesin-like protein in Drosophila: possible roles in axonal transport. The Journal of Cell Biology. 127: 1041-8. PMID 7525600 DOI: 10.1083/Jcb.127.4.1041  0.369
1993 Lee JK, Coyne RS, Dubreuil RR, Goldstein LS, Branton D. Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster. The Journal of Cell Biology. 123: 1797-809. PMID 8276898 DOI: 10.1083/jcb.123.6.1797  0.738
1991 Dubreuil RR, Brandin E, Reisberg JH, Goldstein LS, Branton D. Structure, calmodulin-binding, and calcium-binding properties of recombinant alpha spectrin polypeptides. The Journal of Biological Chemistry. 266: 7189-93. PMID 2016322  0.722
1991 Saxton WM, Hicks J, Goldstein LS, Raff EC. Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis. Cell. 64: 1093-102. PMID 1825937 DOI: 10.1016/0092-8674(91)90264-Y  0.334
1989 Dubreuil RR, Byers TJ, Sillman AL, Bar-Zvi D, Goldstein LS, Branton D. The complete sequence of Drosophila alpha-spectrin: conservation of structural domains between alpha-spectrins and alpha-actinin. The Journal of Cell Biology. 109: 2197-205. PMID 2808524 DOI: 10.1083/Jcb.109.5.2197  0.713
1989 Byers TJ, Husain-Chishti A, Dubreuil RR, Branton D, Goldstein LS. Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin. The Journal of Cell Biology. 109: 1633-41. PMID 2677025 DOI: 10.1083/Jcb.109.4.1633  0.723
1989 Kiehart DP, Lutz MS, Chan D, Ketchum AS, Laymon RA, Nguyen B, Goldstein LS. Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family. The Embo Journal. 8: 913-22. PMID 2498088 DOI: 10.1002/J.1460-2075.1989.Tb03452.X  0.596
1987 Dubreuil R, Byers TJ, Branton D, Goldstein LS, Kiehart DP. Drosophilia spectrin. I. Characterization of the purified protein. The Journal of Cell Biology. 105: 2095-102. PMID 3680372 DOI: 10.1083/Jcb.105.5.2095  0.775
1987 Byers TJ, Dubreuil R, Branton D, Kiehart DP, Goldstein LS. Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins. The Journal of Cell Biology. 105: 2103-10. PMID 2824526 DOI: 10.1083/Jcb.105.5.2103  0.774
1982 Goldstein LS, Hardy RW, Lindsley DL. Structural genes on the Y chromosome of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 79: 7405-9. PMID 6818544  0.504
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