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Dimitry Ofengeim - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Neurodegeneration
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim H, Urquhart R, Pontarelli F, Jover-Mengual T, Ofengeim D, Hwang JY. Protocol for establishing a global ischemia model using a 4-vessel occlusion in rats. Star Protocols. 4: 102630. PMID 38264871 DOI: 10.1016/j.xpro.2023.102630  0.679
2023 Yuan J, Ofengeim D. A guide to cell death pathways. Nature Reviews. Molecular Cell Biology. PMID 38110635 DOI: 10.1038/s41580-023-00689-6  0.526
2023 Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Ofengeim D, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w  0.315
2020 Mifflin L, Ofengeim D, Yuan J. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nature Reviews. Drug Discovery. PMID 32669658 DOI: 10.1038/S41573-020-0071-Y  0.739
2019 Degterev A, Ofengeim D, Yuan J. Targeting RIPK1 for the treatment of human diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 31048504 DOI: 10.1073/Pnas.1901179116  0.589
2018 Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nature Reviews. Neuroscience. PMID 30467385 DOI: 10.1038/S41583-018-0093-1  0.618
2018 Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death and Differentiation. PMID 30341420 DOI: 10.1038/S41418-018-0215-3  0.536
2018 Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. PMID 30146158 DOI: 10.1016/J.Cell.2018.07.041  0.735
2018 Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J. Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891719 DOI: 10.1073/Pnas.1806973115  0.579
2018 Chen H, Kankel MW, Su SC, Han SWS, Ofengeim D. Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD. Cell Death and Differentiation. PMID 29459769 DOI: 10.1038/S41418-018-0060-4  0.376
2018 Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J. Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death. Cell Death & Disease. 9: 138. PMID 29374185 DOI: 10.1038/S41419-017-0170-9  0.556
2017 Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28904096 DOI: 10.1073/Pnas.1714175114  0.74
2017 Ofengeim D, Giagtzoglou N, Huh D, Zou C, Yuan J. Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time. Trends in Molecular Medicine. PMID 28501348 DOI: 10.1016/J.Molmed.2017.04.006  0.506
2016 Hwang JY, Gertner M, Pontarelli F, Court-Vazquez B, Bennett MV, Ofengeim D, Zukin RS. Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die. Cell Death and Differentiation. PMID 27935582 DOI: 10.1038/Cdd.2016.140  0.775
2016 Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CM. Activation of necroptosis in human and experimental cholestasis. Cell Death & Disease. 7: e2390. PMID 27685634 DOI: 10.1038/Cddis.2016.280  0.537
2016 Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, et al. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science (New York, N.Y.). 353: 603-8. PMID 27493188 DOI: 10.1126/Science.Aaf6803  0.532
2016 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Corrigendum: Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 30: 870. PMID 27036968 DOI: 10.1101/Gad.280453.116  0.478
2016 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, et al. Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. PMID 27002169 DOI: 10.1083/Jcb.20150304403082016C  0.513
2016 Afonso M, Rodrigues P, Simão A, Cortez-Pinto H, Ofengeim D, Amaral J, Castro R, Yuan J, Rodrigues C. RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death Journal of Hepatology. 64: S349. DOI: 10.1016/S0168-8278(16)00504-3  0.541
2015 Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. The Journal of Cell Biology. 210: 705-16. PMID 26323688 DOI: 10.1083/Jcb.201503044  0.563
2015 Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, et al. Activation of necroptosis in multiple sclerosis. Cell Reports. 10: 1836-49. PMID 25801023 DOI: 10.1016/J.Celrep.2015.02.051  0.54
2015 Afonso M, Rodrigues P, Simão A, Cortez-Pinto H, Ofengeim D, Amaral J, Castro R, Yuan J, Rodrigues C. P1193 : Necroptosis contributes to the pathogenesis of cholestatic liver injury Journal of Hepatology. 62: S802-S803. DOI: 10.1016/S0168-8278(15)31389-1  0.462
2013 Ofengeim D, Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nature Reviews. Molecular Cell Biology. 14: 727-36. PMID 24129419 DOI: 10.1038/Nrm3683  0.607
2013 Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J. Chaperone-mediated autophagy degrades mutant p53. Genes & Development. 27: 1718-30. PMID 23913924 DOI: 10.1101/Gad.220897.113  0.518
2012 Pontarelli F, Ofengeim D, Zukin RS, Jonas EA. Mouse Transient Global Ischemia Two-Vessel Occlusion Model. Bio-Protocol. 2. PMID 27446974  0.587
2012 Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA. N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neuroscience. 15: 574-80. PMID 22366758 DOI: 10.1038/Nn.3054  0.631
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/Jbc.M111.290957  0.578
2011 Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MVL, Zukin RS, Jonas EA. Ischemic preconditioning blocks BAD translocation, Bcl-x L cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (4892-4897) DOI: 10.1073/pnas.0800628105) Proceedings of the National Academy of Sciences of the United States of America. 108: 16855-16857. DOI: 10.1073/Pnas.1111311108  0.715
2011 Ofengeim D, Miyawaki T, Zukin RS. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death Stroke. 75-106. DOI: 10.1016/B978-1-4160-5478-8.10006-5  0.561
2009 Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS. The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nature Neuroscience. 12: 618-26. PMID 19349976 DOI: 10.1038/Nn.2299  0.761
2008 Miyawaki T, Mashiko T, Ofengeim D, Flannery RJ, Noh KM, Fujisawa S, Bonanni L, Bennett MV, Zukin RS, Jonas EA. Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 4892-7. PMID 18347331 DOI: 10.1073/Pnas.0800628105  0.743
2006 Bonanni L, Chachar M, Jover-Mengual T, Li H, Jones A, Yokota H, Ofengeim D, Flannery RJ, Miyawaki T, Cho CH, Polster BM, Pypaert M, Hardwick JM, Sensi SL, Zukin RS, et al. Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6851-62. PMID 16793892 DOI: 10.1523/Jneurosci.5444-05.2006  0.563
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