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Taekjip Ha, Ph.D. - Publications

Affiliations: 
2000-2015 Physics University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 2015-2023 Johns Hopkins University, Baltimore, MD 
 2023- Harvard University, Cambridge, MA, United States 
Area:
Single molecule
Website:
http://bio.phyiscs.uiuc.edu
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Year Citation  Score
2024 Li J, Jo MH, Yan J, Hall T, Lee J, López-Sánchez U, Yan S, Ha T, Springer TA. Ligand binding initiates single-molecule integrin conformational activation. Cell. PMID 38772370 DOI: 10.1016/j.cell.2024.04.049  0.532
2024 Pangeni S, Biswas G, Kaushik V, Kuppa S, Yang O, Lin CT, Mishra G, Levy Y, Antony E, Ha T. Rapid long-distance migration of RPA on single stranded DNA occurs through intersegmental transfer utilizing multivalent interactions. Journal of Molecular Biology. 168491. PMID 38360091 DOI: 10.1016/j.jmb.2024.168491  0.325
2023 Merino Urteaga R, Ha T. Mind your tag in single-molecule measurements. Cell Reports Methods. 3: 100623. PMID 37883922 DOI: 10.1016/j.crmeth.2023.100623  0.34
2023 Bobrovnikov D, Makurath MA, Wolfe CH, Chemla YR, Ha T. Helicase Activity Modulation with On-Demand Light-Based Conformational Control. Journal of the American Chemical Society. 145: 21253-21262. PMID 37739407 DOI: 10.1021/jacs.3c05254  0.625
2023 Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, et al. Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins. Nature Methods. PMID 36973549 DOI: 10.1038/s41592-023-01807-0  0.806
2023 Husbands AY, Feller A, Aggarwal V, Dresden CE, Holub AS, Ha T, Timmermans MCP. The START domain potentiates HD-ZIPIII transcriptional activity. The Plant Cell. PMID 36861320 DOI: 10.1093/plcell/koad058  0.753
2022 Okafor IC, Ha T. Single Molecule FRET Analysis of CRISPR Cas9 Single Guide RNA Folding Dynamics. The Journal of Physical Chemistry. B. 127: 45-51. PMID 36563314 DOI: 10.1021/acs.jpcb.2c05428  0.336
2022 Jo MH, Li J, Jaumouillé V, Hao Y, Coppola J, Yan J, Waterman CM, Springer TA, Ha T. Single-molecule characterization of subtype-specific β1 integrin mechanics. Nature Communications. 13: 7471. PMID 36463259 DOI: 10.1038/s41467-022-35173-w  0.45
2022 Gavrilov M, Yang JYC, Zou RS, Ma W, Lee CY, Mohapatra S, Kang J, Liao TW, Myong S, Ha T. Engineered helicase replaces thermocycler in DNA amplification while retaining desired PCR characteristics. Nature Communications. 13: 6312. PMID 36274095 DOI: 10.1038/s41467-022-34076-0  0.806
2022 Zou RS, Marin-Gonzalez A, Liu Y, Liu HB, Shen L, Dveirin RK, Luo JXJ, Kalhor R, Ha T. Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nature Cell Biology. 24: 1433-1444. PMID 36064968 DOI: 10.1038/s41556-022-00975-z  0.313
2022 Laszlo AH, Craig JM, Gavrilov M, Tippana R, Nova IC, Huang JR, Kim HC, Abell SJ, deCampos-Stairiker M, Mount JW, Bowman JL, Baker KS, Higinbotham H, Bobrovnikov D, Ha T, et al. Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution. Proceedings of the National Academy of Sciences of the United States of America. 119: e2202489119. PMID 36037333 DOI: 10.1073/pnas.2202489119  0.317
2022 Umanah GKE, Abalde-Atristain L, Khan MR, Mitra J, Dar MA, Chang M, Tangella K, McNamara A, Bennett S, Chen R, Aggarwal V, Cortes M, Worley PF, Ha T, Dawson TM, et al. AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1. Nature Communications. 13: 4836. PMID 35977929 DOI: 10.1038/s41467-022-32365-2  0.74
2022 Paul T, Opresko PL, Ha T, Myong S. Vectorial folding of telomere overhang promotes higher accessibility. Nucleic Acids Research. PMID 35687089 DOI: 10.1093/nar/gkac401  0.749
2022 Moghimianavval H, Patel C, Mohapatra S, Hwang SW, Kayikcioglu T, Bashirzadeh Y, Liu AP, Ha T. Engineering Functional Membrane-Membrane Interfaces by InterSpy. Small (Weinheim An Der Bergstrasse, Germany). e2202104. PMID 35618485 DOI: 10.1002/smll.202202104  0.774
2022 Ha T, Kaiser C, Myong S, Wu B, Xiao J. Next generation single-molecule techniques: Imaging, labeling, and manipulation in vitro and in cellulo. Molecular Cell. 82: 304-314. PMID 35063098 DOI: 10.1016/j.molcel.2021.12.019  0.638
2021 Dai L, Singh D, Lu S, Kottadiel VI, Vafabakhsh R, Mahalingam M, Chemla YR, Ha T, Rao VB. A viral genome packaging ring-ATPase is a flexibly coordinated pentamer. Nature Communications. 12: 6548. PMID 34772936 DOI: 10.1038/s41467-021-26800-z  0.711
2021 Okafor IC, Choi J, Ha T. Single Molecule Methods for studying CRISPR Cas9-Induced DNA Unwinding. Methods (San Diego, Calif.). PMID 34767923 DOI: 10.1016/j.ymeth.2021.11.003  0.336
2021 Zou RS, Liu Y, Ha T. Cleavage and Electrophoretic Mobility Shift Assays for Very Fast CRISPR. Bio-Protocol. 11: e4138. PMID 34604444 DOI: 10.21769/BioProtoc.4138  0.324
2021 Feng XA, Poyton MF, Ha T. Multicolor single-molecule FRET for DNA and RNA processes. Current Opinion in Structural Biology. 70: 26-33. PMID 33894656 DOI: 10.1016/j.sbi.2021.03.005  0.349
2021 Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Sung Jung H, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, ... Ha T, et al. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. Elife. 10. PMID 33779550 DOI: 10.7554/eLife.60416  0.78
2021 Paul T, Ha T, Myong S. Regeneration of PEG slide for multiple rounds of single molecule measurements. Biophysical Journal. PMID 33675764 DOI: 10.1016/j.bpj.2021.02.031  0.776
2021 Poddar A, Azam MS, Kayikcioglu T, Bobrovskyy M, Zhang J, Ma X, Labhsetwar P, Fei J, Singh D, Luthey-Schulten Z, Vanderpool CK, Ha T. Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA. Nature Communications. 12: 874. PMID 33558533 DOI: 10.1038/s41467-021-21144-0  0.58
2021 Wang Y, Mallon J, Wang H, Singh D, Hyun Jo M, Hua B, Bailey S, Ha T. Real-time observation of Cas9 postcatalytic domain motions. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33443184 DOI: 10.1073/pnas.2010650118  0.636
2020 Rhine K, Makurath MA, Liu J, Skanchy S, Lopez C, Catalan KF, Ma Y, Fare CM, Shorter J, Ha T, Chemla YR, Myong S. ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS. Molecular Cell. 80: 1139. PMID 33338404 DOI: 10.1016/j.molcel.2020.11.031  0.66
2020 Rhine K, Makurath MA, Liu J, Skanchy S, Lopez C, Catalan KF, Ma Y, Ha T, Chemla YR, Myong S. ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS. Molecular Cell. PMID 33159856 DOI: 10.1016/j.molcel.2020.10.014  0.678
2020 Hua B, Jones CP, Mitra J, Murray PJ, Rosenthal R, Ferré-D'Amaré AR, Ha T. Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape. Nature Communications. 11: 4531. PMID 32913225 DOI: 10.1038/S41467-020-18283-1  0.369
2020 Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T. Very fast CRISPR on demand. Science (New York, N.Y.). 368: 1265-1269. PMID 32527834 DOI: 10.1126/Science.Aay8204  0.435
2020 Huang L, Liao TW, Wang J, Ha T, Lilley DMJ. Crystal structure and ligand-induced folding of the SAM/SAH riboswitch. Nucleic Acids Research. PMID 32520325 DOI: 10.1093/Nar/Gkaa493  0.329
2020 Paul T, Voter AF, Cueny RR, Gavrilov M, Ha T, Keck JL, Myong S. E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands. Nucleic Acids Research. PMID 32449930 DOI: 10.1093/Nar/Gkaa442  0.737
2020 Korman A, Sun H, Hua B, Yang H, Capilato JN, Paul R, Panja S, Ha T, Greenberg MM, Woodson SA. Light-controlled twister ribozyme with single-molecule detection resolves RNA function in time and space. Proceedings of the National Academy of Sciences of the United States of America. PMID 32430319 DOI: 10.1073/Pnas.2003425117  0.367
2020 Hsu RYC, Lin YC, Redon C, Sun Q, Singh DK, Wang Y, Aggarwal V, Mitra J, Matur A, Moriarity B, Ha T, Aladjem MI, Prasanth KV, Prasanth SG. ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization. Iscience. 23: 101038. PMID 32344376 DOI: 10.1016/J.Isci.2020.101038  0.768
2020 Gitler AD, Shorter J, Ha T, Myong S. Just Took a DNA Test, Turns Out 100% Not That Phase. Molecular Cell. 78: 193-194. PMID 32302539 DOI: 10.1016/J.Molcel.2020.03.029  0.567
2020 Jo MH, Li J, Springer TA, Ha T. Integrin-Dependent Difference in Cell Adhesion and Force Exertion Biophysical Journal. 118: 96a. DOI: 10.1016/J.Bpj.2019.11.686  0.444
2020 Bianchi DM, Breuer M, Lam V, Poddar A, Wise KS, Hutchison CA, Smith HO, Villa E, Ha T, Glass JI, Luthey-Schulten Z. Modeling the Lipid Metabolism of a Genetically Minimal Cell Biophysical Journal. 118: 346a. DOI: 10.1016/J.Bpj.2019.11.1999  0.485
2019 Su N, Byrd AK, Bharath SR, Yang O, Jia Y, Tang X, Ha T, Raney KD, Song H. Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases. Nature Communications. 10: 5375. PMID 31772234 DOI: 10.2210/Pdb6L3G/Pdb  0.421
2019 Okafor IC, Singh D, Wang Y, Jung M, Wang H, Mallon J, Bailey S, Lee JK, Ha T. Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding. Nucleic Acids Research. PMID 31713616 DOI: 10.1093/Nar/Gkz1058  0.64
2019 Mohapatra S, Lin CT, Feng XA, Basu A, Ha T. Single-Molecule Analysis and Engineering of DNA Motors. Chemical Reviews. PMID 31661246 DOI: 10.1021/Acs.Chemrev.9B00361  0.805
2019 Mitra J, Ha T. Streamlining effects of extra telomeric repeat on telomeric DNA folding revealed by fluorescence-force spectroscopy. Nucleic Acids Research. PMID 31617570 DOI: 10.1093/Nar/Gkz906  0.387
2019 Mitra J, Ha T. Nanomechanics and co-transcriptional folding of Spinach and Mango. Nature Communications. 10: 4318. PMID 31541108 DOI: 10.1038/S41467-019-12299-Y  0.359
2019 Mitra J, Makurath MA, Ngo TTM, Troitskaia A, Chemla YR, Ha T. Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. PMID 30944218 DOI: 10.1073/Pnas.1815162116  0.672
2019 Geiger-Schuller K, Mitra J, Ha T, Barrick D. Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays. Elife. 8. PMID 30810525 DOI: 10.7554/Elife.38298  0.417
2019 Schlierf M, Wang G, Chen XS, Ha T. Hexameric helicase G40P unwinds DNA in single base pair steps. Elife. 8. PMID 30688211 DOI: 10.7554/Elife.42001  0.707
2019 Zhou R, Yang O, Déclais AC, Jin H, Gwon GH, Freeman ADJ, Cho Y, Lilley DMJ, Ha T. Junction resolving enzymes use multivalency to keep the Holliday junction dynamic. Nature Chemical Biology. PMID 30664685 DOI: 10.1038/S41589-018-0209-Y  0.362
2019 Ha T, Enderle T, Chemla S, Selvin R, Weiss S. Single Molecule Dynamics Studied by Polarization Modulation. Physical Review Letters. 77: 3979-3982. PMID 10062357 DOI: 10.1103/Physrevlett.77.3979  0.544
2019 Schlierf M, Wang G, Chen XS, Ha T. Author response: Hexameric helicase G40P unwinds DNA in single base pair steps Elife. DOI: 10.7554/Elife.42001.017  0.654
2019 Geiger-Schuller K, Mitra J, Ha T, Barrick D. Author response: Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays Elife. DOI: 10.7554/Elife.38298.031  0.333
2019 Kothari P, Srivastava V, Aggarwal V, Tchernyshyov I, Van Eyk J, Ha T, Robinson DN. Mapping the Biochemical Interactions of the Mechanoresponsive Contractility Controller Biophysical Journal. 116: 119a-120a. DOI: 10.1016/J.Bpj.2018.11.669  0.734
2019 Mitra J, Ha T. Manipulation of GQ-Based RNA Aptamers at the Single Molecule Level using Integrated Force-Fluorescence Spectroscopy Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1932  0.372
2018 Kothari P, Srivastava V, Aggarwal V, Tchernyshyov I, Van Eyk JE, Ha T, Robinson DN. Contractility kits promote assembly of the mechanoresponsive cytoskeletal network. Journal of Cell Science. PMID 30559246 DOI: 10.1242/Jcs.226704  0.773
2018 Dubiel K, Myers AR, Kozlov AG, Yang O, Zhang J, Ha T, Lohman TM, Keck JL. Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins. Journal of Molecular Biology. PMID 30472092 DOI: 10.1016/J.Jmb.2018.11.019  0.378
2018 Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Adariani SR, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, ... ... Ha T, et al. Publisher Correction: Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods. PMID 30327572 DOI: 10.1038/S41592-018-0193-X  0.78
2018 Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Rezaei Adariani S, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, ... ... Ha T, et al. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods. 15: 669-676. PMID 30171252 DOI: 10.1038/S41592-018-0085-0  0.798
2018 Hua B, Panja S, Wang Y, Woodson S, Ha T. Mimicking Co-Transcriptional RNA Folding Using a Superhelicase. Journal of the American Chemical Society. PMID 30063835 DOI: 10.1016/J.Bpj.2017.11.2401  0.4
2018 Lee SJ, Syed S, Ha T. Single-Molecule FRET Analysis of Replicative Helicases. Methods in Molecular Biology (Clifton, N.J.). 1805: 233-250. PMID 29971721 DOI: 10.1007/978-1-4939-8556-2_12  0.474
2018 Wang X, Park S, Zeng L, Jain A, Ha T. Toward Single-Cell Single-Molecule Pull-Down. Biophysical Journal. PMID 29804751 DOI: 10.1016/J.Bpj.2018.05.013  0.479
2018 Koh HR, Roy R, Sorokina M, Tang GQ, Nandakumar D, Patel SS, Ha T. Correlating Transcription Initiation and Conformational Changes by a Single-Subunit RNA Polymerase with Near Base-Pair Resolution. Molecular Cell. 70: 695-706.e5. PMID 29775583 DOI: 10.1016/J.Molcel.2018.04.018  0.762
2018 Singh D, Mallon J, Poddar A, Wang Y, Tippana R, Yang O, Bailey S, Ha T. Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a). Proceedings of the National Academy of Sciences of the United States of America. PMID 29735714 DOI: 10.1073/Pnas.1718686115  0.655
2018 Chowdhury F, Doğanay S, Leslie BJ, Singh R, Amar K, Talluri B, Park S, Wang N, Ha T. Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells. Biochemical and Biophysical Research Communications. PMID 29673588 DOI: 10.1016/J.Bbrc.2018.04.085  0.329
2018 Singh D, Wang Y, Mallon J, Yang O, Fei J, Poddar A, Ceylan D, Bailey S, Ha T. Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis. Nature Structural & Molecular Biology. 25: 347-354. PMID 29622787 DOI: 10.1038/S41594-018-0051-7  0.656
2018 Yang O, Ha T. Single-Molecule Studies of ssDNA-Binding Proteins Exchange. Methods in Enzymology. 600: 463-477. PMID 29458770 DOI: 10.1016/Bs.Mie.2017.11.017  0.479
2018 Hua B, Wang Y, Park S, Han KY, Singh D, Kim JH, Cheng W, Ha T. Single-molecule centroid localization algorithm improves the accuracy of fluorescence binding assays. Biochemistry. PMID 29457977 DOI: 10.1021/Acs.Biochem.7B01293  0.672
2018 Singh D, Ha T. Understanding the molecular mechanisms of CRISPR toolbox using single molecule approaches. Acs Chemical Biology. PMID 29394047 DOI: 10.1021/Acschembio.7B00905  0.634
2018 Jo MH, Cottle WT, Ha T. Real-Time Measurement of Molecular Tension during Cell Adhesion and Migration Using Multiplexed Differential Analysis of Tension Gauge Tethers Acs Biomaterials Science & Engineering. 5: 3856-3863. DOI: 10.1021/Acsbiomaterials.8B01216  0.368
2018 Kayikcioglu T, Lin C, Ha T. Massively Parallel Measurement of DNA Mismatch Repair Efficiency In Vivo Biophysical Journal. 114: 83a. DOI: 10.1016/J.Bpj.2017.11.500  0.343
2018 Wang Y, Singh D, Mallon J, Hua B, Bailey S, Ha T. Simultaneous Real-Time Observation of DNA Unwinding and Nuclease Domain Activation in Cas9-RNA-DNA Complex via Three-Color Single Molecule FRET Biophysical Journal. 114: 572a. DOI: 10.1016/J.Bpj.2017.11.3127  0.673
2018 Basu A, Morgan MT, Huaman BC, Kayikcioglu T, Ngo T, Zhang Q, Wolberger C, Ha T. Genome Wide Measurements of the Sequence Dependence of Nucleosomal DNA Flexibility Biophysical Journal. 114: 446a. DOI: 10.1016/J.Bpj.2017.11.2465  0.304
2017 Zhang Y, Ha T, Marqusee S. Editorial Overview: Single-Molecule Approaches up to Difficult Challenges in Folding and Dynamics. Journal of Molecular Biology. PMID 29288633 DOI: 10.1016/J.Jmb.2017.12.019  0.353
2017 Fei J, Jadaliha M, Harmon TS, Li ITS, Hua B, Hao Q, Holehouse AS, Reyer M, Sun Q, Freier SM, Pappu RV, Prasanth KV, Ha T. Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution. Journal of Cell Science. PMID 29133588 DOI: 10.1242/Jcs.206854  0.313
2017 Figiel M, Krepl M, Park S, Poznański J, Skowronek K, Gołąb A, Ha T, Šponer J, Nowotny M. Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase. The Journal of Biological Chemistry. PMID 29122886 DOI: 10.1074/Jbc.M117.798256  0.349
2017 Doğanay S, Lee MY, Baum A, Peh J, Hwang SY, Yoo JY, Hergenrother PJ, García-Sastre A, Myong S, Ha T. Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 29098213 DOI: 10.1039/C7Ib00146K  0.556
2017 Abeysirigunawardena SC, Kim H, Lai J, Ragunathan K, Rappé MC, Luthey-Schulten Z, Ha T, Woodson SA. Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes. Nature Communications. 8: 492. PMID 28887451 DOI: 10.1038/S41467-017-00536-1  0.749
2017 Li IT, Ha T, Chemla YR. Mapping cell surface adhesion by rotation tracking and adhesion footprinting. Scientific Reports. 7: 44502. PMID 28290531 DOI: 10.1038/Srep44502  0.764
2017 Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC. Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science (New York, N.Y.). PMID 28254785 DOI: 10.1126/Science.Aaf9739  0.309
2017 Lin CT, Tritschler F, Lee KS, Gu M, Rice CM, Ha T. Single-molecule Imaging Reveals the Translocation and DNA looping Dynamics of Hepatitis C Virus NS3 Helicase. Protein Science : a Publication of the Protein Society. PMID 28176403 DOI: 10.1002/Pro.3136  0.442
2017 Lin CT, Ha T. Direct Visualization of Helicase Dynamics Using Fluorescence Localization and Optical Trapping. Methods in Enzymology. 582: 121-136. PMID 28062032 DOI: 10.1016/Bs.Mie.2016.08.004  0.432
2017 Lin CT, Ha T. Probing Single Helicase Dynamics on Long Nucleic Acids Through Fluorescence-Force Measurement. Methods in Molecular Biology (Clifton, N.J.). 1486: 295-316. PMID 27844433 DOI: 10.1007/978-1-4939-6421-5_11  0.426
2017 Singh D, Mallon J, Tipanna R, Poddar A, Yang O, Bailey S, Ha T. Investigation of DNA Binding, Nucleolysis and Product Release Specificity of RNA Guided Endonuclease CRISPR-Cpf1 Family Reveals Important Differences from Cas9-RNA Biophysical Journal. 112: 472a. DOI: 10.1016/J.Bpj.2016.11.2531  0.618
2017 Woodson SA, Panja S, Hua B, Sarkar K, Ha T. Cleaving Fast and Slow: Strategies for Self-Assembly of Catalytic RNA Biophysical Journal. 112: 26a. DOI: 10.1016/J.Bpj.2016.11.176  0.319
2017 Yoo J, Park S, Kim H, Ha T, Aksimentiev A. High Throughput Simulations Reveal how Sequence and Methylation Control DNA Looping and Self-Association Biophysical Journal. 112: 6a. DOI: 10.1016/J.Bpj.2016.11.053  0.373
2016 Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Research. PMID 27956502 DOI: 10.1093/Nar/Gkw1229  0.352
2016 Rahil Z, Pedron S, Wang X, Ha T, Harley B, Leckband D. Correction: Nanoscale mechanics guides cellular decision making. Integrative Biology : Quantitative Biosciences From Nano to Macro. 8: 1002. PMID 27714010 DOI: 10.1039/C6Ib90035F  0.337
2016 Aggarwal V, Ha T. Single-molecule fluorescence microscopy of native macromolecular complexes. Current Opinion in Structural Biology. 41: 225-232. PMID 27662375 DOI: 10.1016/J.Sbi.2016.09.006  0.806
2016 Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nature Communications. 7: 12778. PMID 27624851 DOI: 10.1038/Ncomms12778  0.666
2016 Park JM, Kim HI, Han SU, Yang HK, Kim YW, Lee HJ, An JY, Kim MC, Park S, Song KY, Oh SJ, Kong SH, Suh BJ, Yang DH, Ha TK, et al. Who may benefit from robotic gastrectomy?: A subgroup analysis of multicenter prospective comparative study data on robotic versus laparoscopic gastrectomy. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. PMID 27514719 DOI: 10.1016/j.ejso.2016.07.012  0.442
2016 Jung YH, Ha TM, Oh CY, Lee US, Jang JH, Kim J, Park JO, Kang DH. The Effects of an Online Mind-Body Training Program on Stress, Coping Strategies, Emotional Intelligence, Resilience and Psychological State. Plos One. 11: e0159841. PMID 27479499 DOI: 10.1371/journal.pone.0159841  0.408
2016 Rahil Z, Pedron S, Wang X, Ha T, Harley B, Leckband D. Nanoscale mechanics guides cellular decision making. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27477049 DOI: 10.1039/C6Ib00113K  0.399
2016 Husbands A, Aggarwal V, Ha T, Timmermans MC. In Planta Single-Molecule Pull-down (SiMPull) Reveals Tetrameric Stoichiometry of HD-ZIPIII:LITTLE ZIPPER Complexes. The Plant Cell. PMID 27385814 DOI: 10.1105/Tpc.16.00289  0.795
2016 Chowdhury F, Li IT, Ngo TT, Leslie BJ, Kim BC, Sokoloski JE, Weiland E, Wang X, Chemla YR, Lohman TM, Ha T. Defining single molecular forces required for Notch activation using nano yoyo. Nano Letters. PMID 27167603 DOI: 10.1021/Acs.Nanolett.6B01403  0.788
2016 Arauz E, Aggarwal V, Jain A, Ha T, Chen J. Single-Molecule Analysis of Lipid-Protein Interactions in Crude Cell Lysates. Analytical Chemistry. PMID 27015152 DOI: 10.1021/Acs.Analchem.5B04127  0.79
2016 Yoo J, Kim H, Aksimentiev A, Ha T. Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation. Nature Communications. 7: 11045. PMID 27001929 DOI: 10.1038/Ncomms11045  0.399
2016 Ha T. Probing Nature's Nanomachines One Molecule at a Time. Biophysical Journal. 110: 1004-7. PMID 26958873 DOI: 10.1016/J.Bpj.2016.02.009  0.339
2016 Lee MK, Park J, Wang X, Roein-Peikar M, Ko E, Qin E, Lee J, Ha T, Kong H. Rupture force of cell adhesion ligand tethers modulates biological activities of a cell-laden hydrogel. Chemical Communications (Cambridge, England). PMID 26912186 DOI: 10.1039/C6Cc00036C  0.614
2016 Ngo TT, Yoo J, Dai Q, Zhang Q, He C, Aksimentiev A, Ha T. Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability. Nature Communications. 7: 10813. PMID 26905257 DOI: 10.1038/Ncomms10813  0.387
2016 Basu A, Ha T. The light side of the force. Elife. 5. PMID 26902718 DOI: 10.7554/Elife.14274  0.32
2016 Wang X, Rahil Z, Li IT, Chowdhury F, Leckband DE, Chemla YR, Ha T. Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors. Scientific Reports. 6: 21584. PMID 26875524 DOI: 10.1038/Srep21584  0.778
2016 Brenner MD, Zhou R, Conway DE, Lanzano L, Gratton E, Schwartz MA, Ha T. Spider silk peptide is a compact, linear nano-spring ideal for intracellular tension sensing. Nano Letters. PMID 26824190 DOI: 10.1021/Acs.Nanolett.6B00305  0.309
2016 Roein-Peikar M, Xu Q, Wang X, Ha T. Ultrasensitivity of Cell Adhesion to the Presence of Mechanically Strong Ligands Physical Review X. 6. DOI: 10.1103/Physrevx.6.011001  0.374
2016 Roein-Peikar M, Chowdhury F, Leslie B, Park S, Xu Q, Ha T. Ultrasensitivity of Cell Adhesion to the Differential Mechanical Cues and Requirement of Reversibility Biophysical Journal. 110: 94a. DOI: 10.1016/J.Bpj.2015.11.568  0.336
2016 Dai L, Singh D, Vafabakhsh R, Mahalingam M, Kottadiel V, Chemla Y, Ha T, Rao VB. Mechanism of Coordination of the Bacteriophage T4 DNA Packaging Motor Analyzed by Real-Time Single Molecule Fluorescence Assay Biophysical Journal. 110: 46a. DOI: 10.1016/J.Bpj.2015.11.316  0.744
2016 Yoo J, Kim H, Ha T, Aksimentiev A. Effector-Free Molecular Mechanism of Epigenetic Regulation Revealed by Molecular Dynamics Simulations and Single-Molecule FRET Experiments Biophysical Journal. 110: 561a-562a. DOI: 10.1016/J.Bpj.2015.11.3003  0.387
2016 Lin C, Gu M, Rice CM, Zakian VA, Ha T. Probing Helicase Dynamics on Nucleic Acids through Fluorescence-Force Measurements Biophysical Journal. 110: 515a. DOI: 10.1016/J.Bpj.2015.11.2754  0.403
2016 Kayikcioglu T, Ha T. DNA Flexibility does not show Appreciable Temperature Dependence Biophysical Journal. 110: 403a. DOI: 10.1016/J.Bpj.2015.11.2177  0.351
2016 Li IT, Ha T, Chemla YR. Rotation Tracking and Adhesion Footprinting Reveal Asymmetric Rolling Adhesion Mechanism Biophysical Journal. 110: 307a. DOI: 10.1016/J.Bpj.2015.11.1651  0.769
2016 Fei J, Jadaliha M, Li I, Hua B, Prasanth KV, Ha T. Non-Random Compositional Organization of Nuclear Speckles Biophysical Journal. 110: 16a. DOI: 10.1016/J.Bpj.2015.11.142  0.668
2016 Mitra J, Ngo TTM, Ha T. Dynamics of Human Telomeric G-Quadruplex Probed by Single Molecule Fluorescence-Force Spectroscopy Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1026  0.355
2015 Wang S, Vafabakhsh R, Borschel WF, Ha T, Nichols CG. Structural dynamics of potassium-channel gating revealed by single-molecule FRET. Nature Structural & Molecular Biology. PMID 26641713 DOI: 10.1038/Nsmb.3138  0.305
2015 Wang X, Sun J, Xu Q, Chowdhury F, Roein-Peikar M, Wang Y, Ha T. Integrin Molecular Tension within Motile Focal Adhesions. Biophysical Journal. 109: 2259-2267. PMID 26636937 DOI: 10.1016/J.Bpj.2015.10.029  0.431
2015 Zhang J, Fei J, Leslie BJ, Han KY, Kuhlman TE, Ha T. Tandem Spinach Array for mRNA Imaging in Living Bacterial Cells. Scientific Reports. 5: 17295. PMID 26612428 DOI: 10.1038/Srep17295  0.306
2015 Sharma A, Varshney M, Park J, Ha TK, Chae KH, Shin HJ. Bifunctional Ce1-xEuxO2 (0 ≤ x ≤ 0.3) nanoparticles for photoluminescence and photocatalyst applications: an X-ray absorption spectroscopy study. Physical Chemistry Chemical Physics : Pccp. PMID 26499907 DOI: 10.1039/c5cp05251c  0.418
2015 Chowdhury F, Li IT, Leslie BJ, Do?anay S, Singh R, Wang X, Seong J, Lee SH, Park S, Wang N, Ha T. Single molecular force across single integrins dictates cell spreading. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26143887 DOI: 10.1039/C5Ib00080G  0.709
2015 Khan A, Giri S, Wang Y, Chakraborty A, Ghosh AK, Anantharaman A, Aggarwal V, Sathyan KM, Ha T, Prasanth KV, Prasanth SG. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Proceedings of the National Academy of Sciences of the United States of America. 112: 8338-43. PMID 26100909 DOI: 10.1073/Pnas.1424705112  0.771
2015 Kim HI, Han SU, Yang HK, Kim YW, Lee HJ, Ryu KW, Park JM, An JY, Kim MC, Park S, Song KY, Oh SJ, Kong SH, Suh BJ, Yang DH, ... Ha TK, et al. Multicenter Prospective Comparative Study of Robotic Versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma. Annals of Surgery. PMID 26020107 DOI: 10.1097/SLA.0000000000001249  0.398
2015 Giri S, Aggarwal V, Pontis J, Shen Z, Chakraborty A, Khan A, Mizzen C, Prasanth KV, Ait-Si-Ali S, Ha T, Prasanth SG. The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin. Elife. 4. PMID 25922909 DOI: 10.7554/Elife.06496  0.743
2015 Comstock MJ, Whitley KD, Jia H, Sokoloski J, Lohman TM, Ha T, Chemla YR. Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme. Science (New York, N.Y.). 348: 352-4. PMID 25883359 DOI: 10.1126/Science.Aaa0130  0.762
2015 Arslan S, Khafizov R, Thomas CD, Chemla YR, Ha T. Protein structure. Engineering of a superhelicase through conformational control. Science (New York, N.Y.). 348: 344-7. PMID 25883358 DOI: 10.1126/Science.Aaa0445  0.748
2015 Ngo TT, Ha T. Nucleosomes undergo slow spontaneous gaping. Nucleic Acids Research. 43: 3964-71. PMID 25824950 DOI: 10.1093/Nar/Gkv276  0.359
2015 Fei J, Singh D, Zhang Q, Park S, Balasubramanian D, Golding I, Vanderpool CK, Ha T. RNA biochemistry. Determination of in vivo target search kinetics of regulatory noncoding RNA. Science (New York, N.Y.). 347: 1371-4. PMID 25792329 DOI: 10.1126/Science.1258849  0.606
2015 Ngo TT, Zhang Q, Zhou R, Yodh JG, Ha T. Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility. Cell. 160: 1135-44. PMID 25768909 DOI: 10.1016/J.Cell.2015.02.001  0.395
2015 Kim TJ, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y. Distinct mechanisms regulating mechanical force-induced Ca²⁺ signals at the plasma membrane and the ER in human MSCs. Elife. 4: e04876. PMID 25667984 DOI: 10.7554/Elife.04876  0.489
2015 Kim SH, Park J, Joo C, Kim D, Ha T. Dynamic growth and shrinkage govern the pH dependence of RecA filament stability. Plos One. 10: e0115611. PMID 25608006 DOI: 10.1371/Journal.Pone.0115611  0.672
2015 Park JY, Kim DW, Park HK, Ha TK, Jung SJ, Kim do H, Bae SK. Comparison of T stage, N stage, multifocality, and bilaterality in papillary thyroid carcinoma patients according to the presence of coexisting lymphocytic thyroiditis. Endocrine Research. 40: 151-5. PMID 25531396 DOI: 10.3109/07435800.2014.977911  0.406
2015 Giri S, Aggarwal V, Pontis J, Shen Z, Chakraborty A, Khan A, Mizzen C, Prasanth KV, Ait-Si-Ali S, Ha T, Prasanth SG. Author response: The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin Elife. DOI: 10.7554/Elife.06496.022  0.741
2015 Wang X, Ha T. Two Distinct Regimes of Integrin Molecular Forces Biophysical Journal. 108: 4-4. DOI: 10.1016/J.Bpj.2014.11.2705  0.406
2015 Li IT, Ha T, Chemla YR. Tracking Rotation during Leukocyte Rolling Reveals Asymmetric Adhesion Properties Biophysical Journal. 108: 494a. DOI: 10.1016/J.Bpj.2014.11.2701  0.765
2015 Roeinpeikar M, Xu Q, Wang X, Ha T. The Princess and the Pea: A Story of Cell Mechanics Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.1949  0.469
2015 Nguyen CT, Ngo T, Park S, Cox K, Ha T, Luthey-Schulten ZA, Kuhlman TE. Spatial Organization of Ribosome Biogenesis of Escherichia Coli Biophysical Journal. 108: 312a. DOI: 10.1016/J.Bpj.2014.11.1698  0.328
2015 Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-Time Observation of DNA Recognition by the RNA-Guided Endonuclease Cas9 using Single-Molecule FRET Biophysical Journal. 108: 26a. DOI: 10.1016/J.Bpj.2014.11.169  0.674
2015 Sarkar K, Hua B, Ha T, Woodson SA. Kinetic Destabilization through Single Point Mutations Emphasizes the Critical Role Played by Coupled Tertiary Interactions in the Folding of the Azoarcus Ribozyme Biophysical Journal. 108: 236a. DOI: 10.1016/J.Bpj.2014.11.1304  0.318
2014 Jain A, Arauz E, Aggarwal V, Ikon N, Chen J, Ha T. Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown. Proceedings of the National Academy of Sciences of the United States of America. 111: 17833-8. PMID 25453101 DOI: 10.1073/Pnas.1419425111  0.78
2014 Kondabagil K, Dai L, Vafabakhsh R, Ha T, Draper B, Rao VB. Designing a nine cysteine-less DNA packaging motor from bacteriophage T4 reveals new insights into ATPase structure and function. Virology. 468: 660-8. PMID 25443668 DOI: 10.1016/J.Virol.2014.08.033  0.342
2014 Um MY, Park JH, Gwon SY, Ahn J, Jung CH, Ha TY. Agaricus bisporus attenuates dextran sulfate sodium-induced colitis. Journal of Medicinal Food. 17: 1383-5. PMID 25357009 DOI: 10.1089/jmf.2014.3191  0.418
2014 Hua B, Han KY, Zhou R, Kim H, Shi X, Abeysirigunawardena SC, Jain A, Singh D, Aggarwal V, Woodson SA, Ha T. An improved surface passivation method for single-molecule studies. Nature Methods. 11: 1233-6. PMID 25306544 DOI: 10.1038/Nmeth.3143  0.794
2014 Vafabakhsh R, Kondabagil K, Earnest T, Lee KS, Zhang Z, Dai L, Dahmen KA, Rao VB, Ha T. Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4. Proceedings of the National Academy of Sciences of the United States of America. 111: 15096-101. PMID 25288726 DOI: 10.1073/Pnas.1407235111  0.432
2014 Li L, Osdal T, Ho Y, Chun S, McDonald T, Agarwal P, Lin A, Chu S, Qi J, Li L, Hsieh YT, Dos Santos C, Yuan H, Ha TQ, Popa M, et al. SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. Cell Stem Cell. 15: 431-46. PMID 25280219 DOI: 10.1016/J.Stem.2014.08.001  0.336
2014 Ha T. Single-molecule methods leap ahead. Nature Methods. 11: 1015-8. PMID 25264779 DOI: 10.1038/Nmeth.3107  0.364
2014 Müller S, Laxmi-Reddy K, Jena PV, Baptiste B, Dong Z, Godde F, Ha T, Rodriguez R, Balasubramanian S, Huc I. Targeting DNA G-quadruplexes with helical small molecules. Chembiochem : a European Journal of Chemical Biology. 15: 2563-70. PMID 25256604 DOI: 10.1002/Cbic.201402439  0.747
2014 Kim SH, Ragunathan K, Park J, Joo C, Kim D, Ha T. Cooperative conformational transitions keep RecA filament active during ATPase cycle. Journal of the American Chemical Society. 136: 14796-800. PMID 25252114 DOI: 10.1021/Ja506363Y  0.818
2014 Aggarwal V, Ha T. Single-molecule pull-down (SiMPull) for new-age biochemistry: methodology and biochemical applications of single-molecule pull-down (SiMPull) for probing biomolecular interactions in crude cell extracts. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1109-19. PMID 25168682 DOI: 10.1002/Bies.201400090  0.803
2014 Maffeo C, Ngo TT, Ha T, Aksimentiev A. A Coarse-Grained Model of Unstructured Single-Stranded DNA Derived from Atomistic Simulation and Single-Molecule Experiment. Journal of Chemical Theory and Computation. 10: 2891-2896. PMID 25136266 DOI: 10.1021/Ct500193U  0.43
2014 Chemla YR, Ha T. Biophysics. Ultraslow relaxation of confined DNA. Science (New York, N.Y.). 345: 380-1. PMID 25061189 DOI: 10.1126/Science.1256359  0.66
2014 Yang JL, Ha TK, Dhodary B, Kim KH, Park J, Lee CH, Kim YC, Oh WK. Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng. Journal of Natural Products. 77: 1615-23. PMID 24968750 DOI: 10.1021/np5002303  0.43
2014 Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife. 3: e02190. PMID 24843019 DOI: 10.7554/Elife.02190  0.369
2014 Moon E, Chang JS, Choi S, Ha TH, Cha B, Cho HS, Park JM, Lee BD, Lee YM, Choi Y, Ha K. Characteristics of stress-coping behaviors in patients with bipolar disorders. Psychiatry Research. 218: 69-74. PMID 24803186 DOI: 10.1016/j.psychres.2014.03.047  0.41
2014 Lee KS, Marciel AB, Kozlov AG, Schroeder CM, Lohman TM, Ha T. Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transfer. Journal of Molecular Biology. 426: 2413-21. PMID 24792418 DOI: 10.1016/J.Jmb.2014.04.023  0.61
2014 Peterson JR, Labhsetwar P, Ellermeier JR, Kohler PR, Jain A, Ha T, Metcalf WW, Luthey-Schulten Z. Towards a computational model of a methane producing archaeum. Archaea (Vancouver, B.C.). 2014: 898453. PMID 24729742 DOI: 10.1155/2014/898453  0.315
2014 Tang GQ, Nandakumar D, Bandwar RP, Lee KS, Roy R, Ha T, Patel SS. Relaxed rotational and scrunching changes in P266L mutant of T7 RNA polymerase reduce short abortive RNAs while delaying transition into elongation. Plos One. 9: e91859. PMID 24651161 DOI: 10.1371/Journal.Pone.0091859  0.754
2014 Syed S, Pandey M, Patel SS, Ha T. Single-molecule fluorescence reveals the unwinding stepping mechanism of replicative helicase. Cell Reports. 6: 1037-45. PMID 24630993 DOI: 10.1016/J.Celrep.2014.02.022  0.432
2014 Kim TK, Lee JS, Jung HS, Ha TK, Kim SM, Han N, Lee EJ, Kim TN, Kwon MJ, Lee SH, Kim MK, Rhee BD, Park JH. Triiodothyronine induces proliferation of pancreatic β-cells through the MAPK/ERK pathway. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association. 122: 240-5. PMID 24623499 DOI: 10.1055/s-0034-1367060  0.428
2014 Lee SJ, Syed S, Enemark EJ, Schuck S, Stenlund A, Ha T, Joshua-Tor L. Dynamic look at DNA unwinding by a replicative helicase. Proceedings of the National Academy of Sciences of the United States of America. 111: E827-35. PMID 24550505 DOI: 10.1073/Pnas.1322254111  0.396
2014 Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU. Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host & Microbe. 15: 228-38. PMID 24528868 DOI: 10.1016/J.Chom.2014.01.009  0.316
2014 Kim H, Abeysirigunawarden SC, Chen K, Mayerle M, Ragunathan K, Luthey-Schulten Z, Ha T, Woodson SA. Protein-guided RNA dynamics during early ribosome assembly. Nature. 506: 334-8. PMID 24522531 DOI: 10.1038/Nature13039  0.737
2014 Park SJ, Park JM, Pai KS, Ha TS, Lee SD, Baek M. Desmopressin alone versus desmopressin and an anticholinergic in the first-line treatment of primary monosymptomatic nocturnal enuresis: a multicenter study. Pediatric Nephrology (Berlin, Germany). 29: 1195-200. PMID 24477979 DOI: 10.1007/s00467-014-2751-5  0.398
2014 Orrit M, Ha T, Sandoghdar V. Single-molecule optical spectroscopy. Chemical Society Reviews. 43: 973-6. PMID 24429724 DOI: 10.1039/C4Cs90001D  0.315
2014 Bhattacharyya B, George NP, Thurmes TM, Zhou R, Jani N, Wessel SR, Sandler SJ, Ha T, Keck JL. Structural mechanisms of PriA-mediated DNA replication restart. Proceedings of the National Academy of Sciences of the United States of America. 111: 1373-8. PMID 24379377 DOI: 10.1073/Pnas.1318001111  0.413
2014 Zhang J, Zhou R, Inoue J, Mikawa T, Ha T. Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA. Nucleic Acids Research. 42: 3821-32. PMID 24371279 DOI: 10.1093/Nar/Gkt1316  0.455
2014 Kim T, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y. Author response: Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs Elife. DOI: 10.7554/Elife.04876.015  0.484
2014 Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Author response: Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA Elife. DOI: 10.7554/Elife.02190.024  0.332
2014 Lin C, Tritschler F, Suk Lee K, Gu M, Rice CM, Ha T. Single-Molecule Imaging Reveals the Translocation Dynamics of Hepatitis C Virus NS3 Helicase Biophysical Journal. 106: 72a. DOI: 10.1016/J.Bpj.2013.11.474  0.383
2014 Akinyi T, Lee I, Ha T. Single Molecule Observation of Cyclization of Short DNA Duplex Biophysical Journal. 106: 67a-68a. DOI: 10.1016/J.Bpj.2013.11.451  0.626
2014 Han KY, Leslie BJ, Fei J, Zhang J, Ha T. Photophysical Properties of the Spinach-DFHBI RNA Aptamer-Fluorogen Complex and its Applications to Live Cell Imaging with Improved Fluorescence Signal Biophysical Journal. 106: 486a-487a. DOI: 10.1016/J.Bpj.2013.11.4471  0.319
2014 Li IT, Ha T, Chemla YR. Single Molecule Mechano-Memory Biophysical Journal. 106: 786a. DOI: 10.1016/J.Bpj.2013.11.4309  0.776
2014 Wang S, Vafabakhsh R, Borschel W, Ha T, Nichols CG. Structural Dynamics Underlying Pip2 Modulation of Kir Channels Revealed by Single Molecule FRET Biophysical Journal. 106: 748a. DOI: 10.1016/J.Bpj.2013.11.4119  0.316
2014 Kim H, Yoo J, Aksimentiev A, Ha T. ‘At’ Content as a Determinant of the Chromosome Structure Biophysical Journal. 106: 694a. DOI: 10.1016/J.Bpj.2013.11.3840  0.39
2014 Fei J, Singh D, Zhang Q, Park S, Golding I, Vanderpool CK, Ha T. Watching Gene Regulation by Small RNA in Bacteria with Super-Resolution Imaging Biophysical Journal. 106: 434a. DOI: 10.1016/J.Bpj.2013.11.2447  0.613
2014 Tritschler F, Lee KS, Lin C, Gu M, Rice CM, Ha T. Single-Molecule Analysis of Hepatitis C Virus NS3 Helicase Translocating on Single-Stranded RNA Biophysical Journal. 106: 396a. DOI: 10.1016/J.Bpj.2013.11.2235  0.389
2014 Peterson JR, Labhsetwar P, Kohler P, Ellermeier J, Metcalf W, Jain A, Ha T, Luthey-Schulten Z. Modeling Metabolic Variability in Methanosarcina Acetivorans Biophysical Journal. 106: 380a. DOI: 10.1016/J.Bpj.2013.11.2148  0.315
2013 Lee JH, Park JH, Ha TS, Han HS. Refractory rickets caused by mild distal renal tubular acidosis. Annals of Pediatric Endocrinology & Metabolism. 18: 152-5. PMID 24904870 DOI: 10.6065/apem.2013.18.3.152  0.403
2013 Ha TH, Jeon TJ, Park JY, Jang YH, Kim DH, Ryu MJ, Sinn DH, Oh TH. [A case of basaloid squamous cell carcinoma of rectosigmoid colon]. The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi. 62: 375-8. PMID 24365738 DOI: 10.4166/kjg.2013.62.6.375  0.417
2013 Park JY, Jeon TJ, Ha TH, Hwang JT, Sinn DH, Oh TH, Shin WC, Choi WC. Bedside index for severity in acute pancreatitis: comparison with other scoring systems in predicting severity and organ failure. Hepatobiliary & Pancreatic Diseases International : Hbpd Int. 12: 645-50. PMID 24322751 DOI: 10.1016/S1499-3872(13)60101-0  0.398
2013 Han KY, Leslie BJ, Fei J, Zhang J, Ha T. Understanding the photophysics of the spinach-DFHBI RNA aptamer-fluorogen complex to improve live-cell RNA imaging. Journal of the American Chemical Society. 135: 19033-8. PMID 24286188 DOI: 10.1021/Ja411060P  0.317
2013 Ha TH, Jeon TJ, Park JY. Differentiation of mucinous cystic neoplasm and cystic changes associated with pancreatic adenocarcinoma. Bmj Case Reports. 2013. PMID 24194164 DOI: 10.1136/bcr-2013-201208  0.412
2013 Ro SH, Jung CH, Hahn WS, Xu X, Kim YM, Yun YS, Park JM, Kim KH, Seo M, Ha TY, Arriaga EA, Bernlohr DA, Kim DH. Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes. Autophagy. 9: 2103-14. PMID 24135897 DOI: 10.4161/Auto.26563  0.438
2013 Fei J, Ha T. Watching DNA breath one molecule at a time. Proceedings of the National Academy of Sciences of the United States of America. 110: 17173-4. PMID 24096577 DOI: 10.1073/Pnas.1316493110  0.399
2013 Ha T. Single-molecule approaches embrace molecular cohorts. Cell. 154: 723-6. PMID 23953107 DOI: 10.1016/J.Cell.2013.07.012  0.365
2013 Yang SK, Shi X, Park S, Ha T, Zimmerman SC. A dendritic single-molecule fluorescent probe that is monovalent, photostable and minimally blinking. Nature Chemistry. 5: 692-7. PMID 23881501 DOI: 10.1038/Nchem.1706  0.373
2013 Jeon TI, Park JW, Ahn J, Jung CH, Ha TY. Fisetin protects against hepatosteatosis in mice by inhibiting miR-378. Molecular Nutrition & Food Research. 57: 1931-7. PMID 23818290 DOI: 10.1002/mnfr.201300071  0.414
2013 Kim SH, Joo C, Ha T, Kim D. Molecular mechanism of sequence-dependent stability of RecA filament. Nucleic Acids Research. 41: 7738-44. PMID 23804763 DOI: 10.1093/Nar/Gkt570  0.6
2013 Wang X, Ha T. Defining single molecular forces required to activate integrin and notch signaling. Science (New York, N.Y.). 340: 991-4. PMID 23704575 DOI: 10.1126/Science.1231041  0.414
2013 Lee KS, Balci H, Jia H, Lohman TM, Ha T. Direct imaging of single UvrD helicase dynamics on long single-stranded DNA. Nature Communications. 4: 1878. PMID 23695672 DOI: 10.1038/Ncomms2882  0.445
2013 Wessel SR, Marceau AH, Massoni SC, Zhou R, Ha T, Sandler SJ, Keck JL. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein. The Journal of Biological Chemistry. 288: 17569-78. PMID 23629733 DOI: 10.1074/Jbc.M113.478156  0.423
2013 Lee JS, Ha TK, Park JH, Lee GM. Anti-cell death engineering of CHO cells: co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction. Biotechnology and Bioengineering. 110: 2195-207. PMID 23436561 DOI: 10.1002/Bit.24879  0.434
2013 Lue NF, Zhou R, Chico L, Mao N, Steinberg-Neifach O, Ha T. The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures. Plos Genetics. 9: e1003145. PMID 23300477 DOI: 10.1371/Journal.Pgen.1003145  0.424
2013 Lai Y, Diao J, Liu Y, Ishitsuka Y, Su Z, Schulten K, Ha T, Shin YK. Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1. Proceedings of the National Academy of Sciences of the United States of America. 110: 1333-8. PMID 23300284 DOI: 10.1073/Pnas.1218818110  0.545
2013 Bae SJ, Ha YM, Kim JA, Park JY, Ha TK, Park D, Chun P, Park NH, Moon HR, Chung HY. A novel synthesized tyrosinase inhibitor: (E)-2-((2,4-dihydroxyphenyl)diazenyl)phenyl 4-methylbenzenesulfonate as an azo-resveratrol analog. Bioscience, Biotechnology, and Biochemistry. 77: 65-72. PMID 23291747 DOI: 10.1271/bbb.120547  0.42
2013 Kim H, Ha T. Single-molecule nanometry for biological physics. Reports On Progress in Physics. Physical Society (Great Britain). 76: 016601. PMID 23249673 DOI: 10.1088/0034-4885/76/1/016601  0.407
2013 Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. The Embo Journal. 32: 126-39. PMID 23178594 DOI: 10.1038/Emboj.2012.314  0.425
2013 Ragunathan K, Liu C, Ha T. Correction: RecA filament sliding on DNA facilitates homology search Elife. 2. DOI: 10.7554/Elife.00488  0.754
2013 Lee I, Akinyi T, Ha T. Single Molecule Observation of Direct Transfer of Escherichia Coli Single-Strand Binding Protein (SSB) between Single-Stranded DNA Molecules Biophysical Journal. 104: 73a. DOI: 10.1016/J.Bpj.2012.11.443  0.667
2013 Kim SH, Ragunathan K, Park J, Joo C, Kim D, Ha T. The ATP Hydrolysis Cycle and the Corresponding Motion of RecA Filament on Single-Stranded DNA Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2998  0.816
2013 Comstock MJ, Jia H, Lohman TM, Ha T, Chemla YR. Simultaneous High-Resolution Optical Trapping and Single Molecule Fluorescence Measurements of the UvrD Helicase: DNA Motor Protein Structure and Function Observed Simultaneously Biophysical Journal. 104: 516a. DOI: 10.1016/J.Bpj.2012.11.2854  0.796
2013 Shen K, Arslan S, Akopian D, Ha T, Shan S. Activated GTPase Movement on SRP RNA Drives Cotranslational Protein Targeting Biophysical Journal. 104: 419a. DOI: 10.1016/J.Bpj.2012.11.2334  0.357
2013 Doganay S, Youzong Lee M, Baum A, Hwang S, Yoo J, Myong S, Garcia Sastre A, Ha T. IFN-Independent Expression of RIG-I is a Determinant of Heterogeneous IFN-B Expression States in Antiviral Signaling Biophysical Journal. 104: 328a. DOI: 10.1016/J.Bpj.2012.11.1822  0.562
2013 Ngo TT, Zhou R, Yodh J, Ha T. Asymmetric Unwrapping of Nucleosome Revealed by Single Molecule Fluorescence-Force Spectroscopy Biophysical Journal. 104: 210a. DOI: 10.1016/J.Bpj.2012.11.1189  0.431
2013 Ha T. Single Molecule Fluorescence-Force Analysis of DNA and Nucleosome Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.017  0.454
2012 Kim TH, Kunz HH, Bhattacharjee S, Hauser F, Park J, Engineer C, Liu A, Ha T, Parker JE, Gassmann W, Schroeder JI. Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis. The Plant Cell. 24: 5177-92. PMID 23275581 DOI: 10.1105/Tpc.112.107235  0.48
2012 Ragunathan K, Liu C, Ha T. RecA filament sliding on DNA facilitates homology search. Elife. 1: e00067. PMID 23240082 DOI: 10.7554/Elife.00067  0.782
2012 Shen K, Arslan S, Akopian D, Ha T, Shan SO. Activated GTPase movement on an RNA scaffold drives co-translational protein targeting. Nature. 492: 271-5. PMID 23235881 DOI: 10.1038/Nature11726  0.368
2012 Joo C, Ha T. Single-molecule FRET with total internal reflection microscopy. Cold Spring Harbor Protocols. 2012. PMID 23209135 DOI: 10.1101/Pdb.Top072058  0.607
2012 Joo C, Ha T. Prism-type total internal reflection microscopy for single-molecule FRET. Cold Spring Harbor Protocols. 2012. PMID 23209134 DOI: 10.1101/Pdb.Prot072041  0.596
2012 Bae SJ, Ha YM, Park YJ, Park JY, Song YM, Ha TK, Chun P, Moon HR, Chung HY. Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors. European Journal of Medicinal Chemistry. 57: 383-90. PMID 23149255 DOI: 10.1016/j.ejmech.2012.09.026  0.422
2012 Joo C, Ha T. Objective-type total internal reflection microscopy (emission) for single-molecule FRET. Cold Spring Harbor Protocols. 2012: 1192-4. PMID 23118359 DOI: 10.1101/pdb.prot072033  0.539
2012 Joo C, Ha T. Objective-type total internal reflection microscopy (excitation) for single-molecule FRET. Cold Spring Harbor Protocols. 2012: 1189-91. PMID 23118358 DOI: 10.1101/Pdb.Prot072025  0.589
2012 Schlierf M, Ha T. A helicase with an extra spring in its step. Cell. 151: 244-6. PMID 23063116 DOI: 10.1016/J.Cell.2012.09.031  0.674
2012 Joo C, Ha T. Imaging and identifying impurities in single-molecule FRET studies. Cold Spring Harbor Protocols. 2012: 1109-12. PMID 23028079 DOI: 10.1101/Pdb.Prot071548  0.622
2012 Joo C, Ha T. Preparing sample chambers for single-molecule FRET. Cold Spring Harbor Protocols. 2012: 1104-8. PMID 23028078 DOI: 10.1101/Pdb.Prot071530  0.605
2012 Zhou R, Ha T. Single-molecule analysis of SSB dynamics on single-stranded DNA. Methods in Molecular Biology (Clifton, N.J.). 922: 85-100. PMID 22976178 DOI: 10.1007/978-1-62703-032-8_5  0.495
2012 Joo C, Ha T. Labeling proteins for single-molecule FRET. Cold Spring Harbor Protocols. 2012: 1009-12. PMID 22949718 DOI: 10.1101/Pdb.Prot071035  0.603
2012 Joo C, Ha T. Labeling DNA (or RNA) for single-molecule FRET. Cold Spring Harbor Protocols. 2012: 1005-8. PMID 22949717 DOI: 10.1101/Pdb.Prot071027  0.633
2012 Vafabakhsh R, Ha T. Extreme bendability of DNA less than 100 base pairs long revealed by single-molecule cyclization. Science (New York, N.Y.). 337: 1097-101. PMID 22936778 DOI: 10.1126/Science.1224139  0.448
2012 Lee G, Bratkowski MA, Ding F, Ke A, Ha T. Elastic coupling between RNA degradation and unwinding by an exoribonuclease. Science (New York, N.Y.). 336: 1726-9. PMID 22745434 DOI: 10.1126/Science.1216848  0.342
2012 Lee G, Ha T. Single-molecule imaging: a collagenase pauses before embarking on a killing spree. Current Biology : Cb. 22: R499-501. PMID 22720688 DOI: 10.1016/J.Cub.2012.04.037  0.35
2012 Shen Z, Chakraborty A, Jain A, Giri S, Ha T, Prasanth KV, Prasanth SG. Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. Molecular and Cellular Biology. 32: 3107-20. PMID 22645314 DOI: 10.1128/Mcb.00362-12  0.422
2012 Diao J, Ishitsuka Y, Lee H, Joo C, Su Z, Syed S, Shin YK, Yoon TY, Ha T. A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins. Nature Protocols. 7: 921-34. PMID 22582418 DOI: 10.1038/Nprot.2012.020  0.745
2012 Cisse II, Kim H, Ha T. A rule of seven in Watson-Crick base-pairing of mismatched sequences. Nature Structural & Molecular Biology. 19: 623-7. PMID 22580558 DOI: 10.1038/Nsmb.2294  0.404
2012 Shi X, Jung Y, Lin LJ, Liu C, Wu C, Cann IK, Ha T. Quantitative fluorescence labeling of aldehyde-tagged proteins for single-molecule imaging. Nature Methods. 9: 499-503. PMID 22466795 DOI: 10.1038/Nmeth.1954  0.498
2012 Chen K, Eargle J, Lai J, Kim H, Abeysirigunawardena S, Mayerle M, Woodson S, Ha T, Luthey-Schulten Z. Assembly of the five-way junction in the ribosomal small subunit using hybrid MD-Gō simulations. The Journal of Physical Chemistry. B. 116: 6819-31. PMID 22458631 DOI: 10.1021/Jp212614B  0.367
2012 Ha T, Kozlov AG, Lohman TM. Single-molecule views of protein movement on single-stranded DNA. Annual Review of Biophysics. 41: 295-319. PMID 22404684 DOI: 10.1146/Annurev-Biophys-042910-155351  0.448
2012 Ha T, Tinnefeld P. Photophysics of fluorescent probes for single-molecule biophysics and super-resolution imaging. Annual Review of Physical Chemistry. 63: 595-617. PMID 22404588 DOI: 10.1146/Annurev-Physchem-032210-103340  0.608
2012 Jain A, Liu R, Xiang YK, Ha T. Single-molecule pull-down for studying protein interactions. Nature Protocols. 7: 445-52. PMID 22322217 DOI: 10.1038/Nprot.2011.452  0.396
2012 Kim H, Tang GQ, Patel SS, Ha T. Opening-closing dynamics of the mitochondrial transcription pre-initiation complex. Nucleic Acids Research. 40: 371-80. PMID 21911357 DOI: 10.1093/Nar/Gkr736  0.365
2012 Ragunathan K, Liu C, Ha T. Author response: RecA filament sliding on DNA facilitates homology search Elife. DOI: 10.7554/Elife.00067.019  0.746
2012 Jia H, Korolev S, Niedziela-Majka A, Maluf NK, Gauss GH, Myong S, Ha T, Waksman G, Lohman TM. Corrigendum to “Rotations of the 2B Sub-Domain of E. coli UvrD Helicase/Translocase Coupled to Nucleotide and DNA Binding” [J. Mol. Biol. 411/3 (2011) 633–648] Journal of Molecular Biology. 418: 264-265. DOI: 10.1016/J.Jmb.2012.02.030  0.588
2012 Kim H, Abeysirigunawardena S, Mayerle M, Ragunathan K, Chen K, Eargle J, Luthey-Schulten Z, Woodson S, Ha T. Single Molecule Views of the Ribosome Assembly Biophysical Journal. 102: 645a. DOI: 10.1016/J.Bpj.2011.11.3512  0.753
2012 Vafabakhsh R, Kondabagil K, Dai L, Zhang Z, Rao VB, Ha T. Analyzing DNA Packaging Initiation of Bacteriophage T4 by a Real-Time Single Molecule Fluorescence Assay Biophysical Journal. 102: 643a. DOI: 10.1016/J.Bpj.2011.11.3497  0.435
2012 Han KY, Ha T. Single Molecule Fluorescence Imaging at Micromolar Concentrations Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3271  0.398
2012 Wang X, Ha T. A Universal Molecular Tension on a Single Integrin during Cell Adhesion Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1902  0.418
2012 Vafabakhsh R, Lee KS, Ha T. Recent advances in studying mechanical properties of DNA Advances in Chemical Physics. 150: 169-186. DOI: 10.1002/9781118197714.Ch4  0.337
2011 Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 108: E1227-35. PMID 22084075 DOI: 10.1073/Pnas.1107182108  0.335
2011 Zhou R, Kunzelmann S, Webb MR, Ha T. Detecting intramolecular conformational dynamics of single molecules in short distance range with subnanometer sensitivity. Nano Letters. 11: 5482-8. PMID 22023515 DOI: 10.1021/Nl2032876  0.413
2011 Ha T, Myong S. A single-molecule view of chaperonin cooperativity. Proceedings of the National Academy of Sciences of the United States of America. 108: 16865-6. PMID 21957072 DOI: 10.1073/Pnas.1113313108  0.639
2011 Balci H, Arslan S, Myong S, Lohman TM, Ha T. Single-molecule nanopositioning: structural transitions of a helicase-DNA complex during ATP hydrolysis. Biophysical Journal. 101: 976-84. PMID 21843490 DOI: 10.1016/J.Bpj.2011.07.010  0.657
2011 Ragunathan K, Joo C, Ha T. Real-time observation of strand exchange reaction with high spatiotemporal resolution. Structure (London, England : 1993). 19: 1064-73. PMID 21827943 DOI: 10.1016/J.Str.2011.06.009  0.814
2011 Hwang KH, Ahn JY, Kim S, Park JH, Ha TY. Abietic acid has an anti-obesity effect in mice fed a high-fat diet. Journal of Medicinal Food. 14: 1052-6. PMID 21812648 DOI: 10.1089/jmf.2010.1471  0.422
2011 Honda M, Okuno Y, Yoo J, Ha T, Spies M. Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. The Embo Journal. 30: 3368-82. PMID 21804533 DOI: 10.1038/Emboj.2011.238  0.391
2011 Zhou R, Kozlov AG, Roy R, Zhang J, Korolev S, Lohman TM, Ha T. SSB functions as a sliding platform that migrates on DNA via reptation. Cell. 146: 222-32. PMID 21784244 DOI: 10.1016/J.Cell.2011.06.036  0.795
2011 Jia H, Korolev S, Niedziela-Majka A, Maluf NK, Gauss GH, Myong S, Ha T, Waksman G, Lohman TM. Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding. Journal of Molecular Biology. 411: 633-48. PMID 21704638 DOI: 10.1016/J.Jmb.2011.06.019  0.643
2011 Yang SK, Shi X, Park S, Doganay S, Ha T, Zimmerman SC. Monovalent, clickable, uncharged, water-soluble perylenediimide-cored dendrimers for target-specific fluorescent biolabeling. Journal of the American Chemical Society. 133: 9964-7. PMID 21671621 DOI: 10.1021/Ja2009136  0.336
2011 Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T. Probing cellular protein complexes using single-molecule pull-down. Nature. 473: 484-8. PMID 21614075 DOI: 10.1038/Nature10016  0.789
2011 Lee G, Yoo J, Leslie BJ, Ha T. Single-molecule analysis reveals three phases of DNA degradation by an exonuclease. Nature Chemical Biology. 7: 367-74. PMID 21552271 DOI: 10.1038/Nchembio.561  0.38
2011 Lee JS, Kim DH, Lee CM, Ha TK, Noh KT, Park JW, Heo DR, Son KH, Jung ID, Lee EK, Shin YK, Ahn SC, Park YM. Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine. Immune Network. 11: 79-94. PMID 21494377 DOI: 10.4110/in.2011.11.1.79  0.416
2011 Zhang Z, Kottadiel VI, Vafabakhsh R, Dai L, Chemla YR, Ha T, Rao VB. A promiscuous DNA packaging machine from bacteriophage T4. Plos Biology. 9: e1000592. PMID 21358801 DOI: 10.1371/Journal.Pbio.1000592  0.668
2011 Liu C, McKinney MC, Chen YH, Earnest TM, Shi X, Lin LJ, Ishino Y, Dahmen K, Cann IK, Ha T. Reverse-chaperoning activity of an AAA+ protein. Biophysical Journal. 100: 1344-52. PMID 21354408 DOI: 10.1016/J.Bpj.2011.01.057  0.767
2011 Comstock MJ, Ha T, Chemla YR. Ultrahigh-resolution optical trap with single-fluorophore sensitivity. Nature Methods. 8: 335-40. PMID 21336286 DOI: 10.1038/Nmeth.1574  0.784
2011 Shi X, Ha T. Seeing a molecular machine self-renew. Proceedings of the National Academy of Sciences of the United States of America. 108: 3459-60. PMID 21325610 DOI: 10.1073/Pnas.1100150108  0.301
2011 Brenner MD, Zhou R, Ha T. Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing. Biopolymers. 95: 332-44. PMID 21267988 DOI: 10.1002/Bip.21587  0.353
2011 Park JH, Ahn J, Kim S, Kwon DY, Ha TY. Murine hepatic miRNAs expression and regulation of gene expression in diet-induced obese mice. Molecules and Cells. 31: 33-8. PMID 21120623 DOI: 10.1007/s10059-011-0009-7  0.43
2011 Zhou R, Kozlov AG, Roy R, Zhang J, Korolev S, Lohman TM, Ha T. Erratum: SSB functions as a sliding platform that migrates on DNA via reptation (Cell (2011) 146 (222-232)) Cell. 146. DOI: 10.1016/J.Cell.2011.07.027  0.646
2011 Kim H, Tang G, Patel SS, Ha T. Promoter Opening-Closing Dynamics of Mitochondrial RNA Polymerase Biophysical Journal. 100: 65a. DOI: 10.1016/J.Bpj.2010.12.555  0.41
2011 Jain A, Liu R, Ramani B, Xiang Y, Ha T. Single Molecule Immunoprecipitation Biophysical Journal. 100: 4-6. DOI: 10.1016/J.Bpj.2010.12.2792  0.405
2011 Lee J, Lee S, Ragunathan K, Joo C, Ha T, Hohng S. First Realization of Single-Molecule Four-Color FRET Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2101  0.791
2011 Diao J, Yoo J, Lee H, Yang Y, Kweon D, Yoon T, Ha T. Synaptotagmin Expands Membrane Fusion Pore by Facilitating SNARE-Complex Formation Biophysical Journal. 100: 185a. DOI: 10.1016/J.Bpj.2010.12.1231  0.632
2011 Vafabakhsh R, Ha T. High Flexibility of Short DNA Probed by Single Molecule Cyclization Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.1185  0.43
2011 Lee G, Bratkowski MA, Ding F, Ke A, Ha T. Single Molecule Analysis of yeast Rrp44 Exonuclease reveals a Spring-Loaded Mechanism of RNA Unwinding Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3628  0.347
2011 Torbeev VY, Myong S, Ha T, Kent SBH. Cover Picture: Single-Molecule Studies of HIV-1 Protease Catalysis Enabled by Chemical Protein Synthesis (Isr. J. Chem. 8-9/2011) Israel Journal of Chemistry. 51: 845-845. DOI: 10.1002/Ijch.201190011  0.597
2011 Torbeev VY, Myong SA, Ha T, Kent SBH. Single-molecule studies of HIV-1 protease catalysis enabled by chemical protein synthesis Israel Journal of Chemistry. 51: 960-967. DOI: 10.1002/Ijch.201100102  0.59
2010 Lee J, Lee S, Ragunathan K, Joo C, Ha T, Hohng S. Single-molecule four-color FRET. Angewandte Chemie (International Ed. in English). 49: 9922-5. PMID 21104966 DOI: 10.1002/Anie.201005402  0.786
2010 Lee G, Hartung S, Hopfner KP, Ha T. Reversible and controllable nanolocomotion of an RNA-processing machinery. Nano Letters. 10: 5123-30. PMID 21082788 DOI: 10.1021/Nl103754Z  0.338
2010 Ishitsuka Y, Okumus B, Arslan S, Chen KH, Ha T. Temperature-independent porous nanocontainers for single-molecule fluorescence studies. Analytical Chemistry. 82: 9694-701. PMID 21038883 DOI: 10.1021/Ac101714U  0.762
2010 Diao J, Su Z, Ishitsuka Y, Lu B, Lee KS, Lai Y, Shin YK, Ha T. A single-vesicle content mixing assay for SNARE-mediated membrane fusion. Nature Communications. 1: 54. PMID 20975723 DOI: 10.1038/Ncomms1054  0.593
2010 Lee JS, Jung ID, Lee CM, Park JW, Chun SH, Jeong SK, Ha TK, Shin YK, Kim DJ, Park YM. Outer membrane protein a of Salmonella enterica serovar Typhimurium activates dendritic cells and enhances Th1 polarization. Bmc Microbiology. 10: 263. PMID 20950448 DOI: 10.1186/1471-2180-10-263  0.45
2010 Tomko EJ, Jia H, Park J, Maluf NK, Ha T, Lohman TM. 5'-Single-stranded/duplex DNA junctions are loading sites for E. coli UvrD translocase. The Embo Journal. 29: 3826-39. PMID 20877334 DOI: 10.1038/Emboj.2010.242  0.603
2010 Park J, Myong S, Niedziela-Majka A, Lee KS, Yu J, Lohman TM, Ha T. PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps. Cell. 142: 544-55. PMID 20723756 DOI: 10.1016/J.Cell.2010.07.016  0.761
2010 Trabuco LG, Schreiner E, Eargle J, Cornish P, Ha T, Luthey-Schulten Z, Schulten K. The role of L1 stalk-tRNA interaction in the ribosome elongation cycle. Journal of Molecular Biology. 402: 741-60. PMID 20691699 DOI: 10.1016/J.Jmb.2010.07.056  0.307
2010 Yodh JG, Schlierf M, Ha T. Insight into helicase mechanism and function revealed through single-molecule approaches. Quarterly Reviews of Biophysics. 43: 185-217. PMID 20682090 DOI: 10.1017/S0033583510000107  0.695
2010 Zhou R, Schlierf M, Ha T. Force-fluorescence spectroscopy at the single-molecule level. Methods in Enzymology. 475: 405-26. PMID 20627166 DOI: 10.1016/S0076-6879(10)75016-3  0.673
2010 Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 466: 263-6. PMID 20613844 DOI: 10.1038/Nature09198  0.306
2010 Shi X, Lim J, Ha T. Acidification of the oxygen scavenging system in single-molecule fluorescence studies: in situ sensing with a ratiometric dual-emission probe. Analytical Chemistry. 82: 6132-8. PMID 20583766 DOI: 10.1021/Ac1008749  0.318
2010 Spies M, Ha T. Inching over hurdles: How DNA helicases move on crowded lattices Cell Cycle. 9: 1742-1749. PMID 20436294 DOI: 10.4161/Cc.9.9.11469  0.437
2010 Liu Y, Park J, Dahmen KA, Chemla YR, Ha T. A comparative study of multivariate and univariate hidden Markov modelings in time-binned single-molecule FRET data analysis. The Journal of Physical Chemistry. B. 114: 5386-403. PMID 20361785 DOI: 10.1021/Jp9057669  0.72
2010 Kim SK, Ha T, Schermann JP. Biomolecular structures: from isolated molecules to the cell crowded medium. Physical Chemistry Chemical Physics : Pccp. 12: 3334-5. PMID 20336242 DOI: 10.1039/C004156B  0.304
2010 Diao J, Su Z, Lu X, Yoon TY, Shin YK, Ha T. Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion. Acs Chemical Neuroscience. 1: 168-174. PMID 20300453 DOI: 10.1021/Cn900034P  0.653
2010 Rothenberg E, Ha T. Single-Molecule FRET Analysis of Helicase Functions Methods of Molecular Biology. 587: 29-43. PMID 20225140 DOI: 10.1007/978-1-60327-355-8_3  0.404
2010 Brenner MD, Scanlan MS, Nahas MK, Ha T, Silverman SK. Multivector fluorescence analysis of the xpt guanine riboswitch aptamer domain and the conformational role of guanine. Biochemistry. 49: 1596-605. PMID 20108980 DOI: 10.1021/Bi9019912  0.7
2010 Grimme JM, Honda M, Wright R, Okuno Y, Rothenberg E, Mazin AV, Ha T, Spies M. Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes Nucleic Acids Research. 38: 2917-2930. PMID 20081207 DOI: 10.1093/Nar/Gkp1249  0.434
2010 Myong S, Ha T. Stepwise translocation of nucleic acid motors Current Opinion in Structural Biology. 20: 121-127. PMID 20061135 DOI: 10.1016/J.Sbi.2009.12.008  0.665
2010 Okumus B, Ha T. Real-time observation of G-quadruplex dynamics using single-molecule FRET microscopy. Methods in Molecular Biology (Clifton, N.J.). 608: 81-96. PMID 20012417 DOI: 10.1007/978-1-59745-363-9_6  0.758
2010 Brenner MD, Scanlan MS, Nahas MK, Ha T, Silverman SK. Correction to Multivector Fluorescence Analysis of thexptGuanine Riboswitch Aptamer Domain and the Conformational Role of Guanine Biochemistry. 49: 2306-2306. DOI: 10.1021/Bi100219D  0.659
2010 Syed S, Pandey M, Patel SS, Ha T. Stepping Mechanism of Bacteriophage T7 Helicase and Priming Loop Observed Using Single-Molecule Fret Methods Biophysical Journal. 98: 66a. DOI: 10.1016/J.Bpj.2009.12.376  0.386
2010 Shi X, Liu C, Cann IK, Ha T. Dynamics of An Archael DNA Polymerase Revealed By Single Molecule Fret Biophysical Journal. 98: 63a-64a. DOI: 10.1016/J.Bpj.2009.12.362  0.544
2010 Diao J, Su Z, Ishitsuka Y, Shin Y, Ha T. Single Molecule Content Mixing Analysis of SNARE-Mediated Membrane Fusion Biophysical Journal. 98: 616a. DOI: 10.1016/J.Bpj.2009.12.3365  0.568
2010 Cisse I, Ha T. The Rule of Seven Revealed by Observing DNA Annealing in a Nanocontainer Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2543  0.406
2010 Zhou R, Roy R, Kozlov AG, Lohman TM, Ha T. Probing Protein Diffusion and Dissociation Mechanisms on DNA Using Fluorescence-Force Spectroscopy Biophysical Journal. 98: 269a. DOI: 10.1016/J.Bpj.2009.12.1464  0.688
2010 Jia H, Niedziela-Majka A, Korolev S, Ha T, Lohman T. Fret Studies of the Conformational Changes in the 2b Sub-Domain of UvrD Helicase Biophysical Journal. 98: 23a. DOI: 10.1016/J.Bpj.2009.12.136  0.381
2010 Park J, Myong S, Niedziela-Majka A, Yu J, Lohman T, Ha T. Reeling in DNA One Base at A Time: pcrA Translocation Coupled to DNA Looping Dismantles RecA Filaments Biophysical Journal. 98: 221a. DOI: 10.1016/J.Bpj.2009.12.1190  0.755
2010 Schlierf M, Wang G, Chen XS, Ha T. Chemo-Mechanical Study of a Hexameric Helicase on the Single-Molecule Level Biophysical Journal. 98: 12a-13a. DOI: 10.1016/J.Bpj.2009.12.075  0.687
2009 Tang GQ, Roy R, Bandwar RP, Ha T, Patel SS. Real-time observation of the transition from transcription initiation to elongation of the RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 106: 22175-80. PMID 20018723 DOI: 10.1073/Pnas.0906979106  0.752
2009 Pandey M, Syed S, Donmez I, Patel G, Ha T, Patel SS. Coordinating DNA replication by means of priming loop and differential synthesis rate. Nature. 462: 940-3. PMID 19924126 DOI: 10.1038/Nature08611  0.402
2009 Roy R, Kozlov AG, Lohman TM, Ha T. SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. Nature. 461: 1092-7. PMID 19820696 DOI: 10.1038/Nature08442  0.796
2009 Okumus B, Arslan S, Fengler SM, Myong S, Ha T. Single molecule nanocontainers made porous using a bacterial toxin. Journal of the American Chemical Society. 131: 14844-9. PMID 19788247 DOI: 10.1021/Ja9042356  0.817
2009 Honda M, Park J, Pugh RA, Ha T, Spies M. Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. Molecular Cell. 35: 694-703. PMID 19748362 DOI: 10.1016/J.Molcel.2009.07.003  0.64
2009 Jena PV, Shirude PS, Okumus B, Laxmi-Reddy K, Godde F, Huc I, Balasubramanian S, Ha T. G-quadruplex DNA bound by a synthetic ligand is highly dynamic. Journal of the American Chemical Society. 131: 12522-3. PMID 19685880 DOI: 10.1021/Ja903408R  0.806
2009 Diao J, Yoon TY, Su Z, Shin YK, Ha T. C2AB: a molecular glue for lipid vesicles with a negatively charged surface. Langmuir : the Acs Journal of Surfaces and Colloids. 25: 7177-80. PMID 19563216 DOI: 10.1021/La901676E  0.634
2009 Sorokina M, Koh HR, Patel SS, Ha T. Fluorescent lifetime trajectories of a single fluorophore reveal reaction intermediates during transcription initiation. Journal of the American Chemical Society. 131: 9630-1. PMID 19552410 DOI: 10.1021/Ja902861F  0.444
2009 Ishitsuka Y, Ha T. DNA nanotechnology: a nanomachine goes live. Nature Nanotechnology. 4: 281-2. PMID 19421208 DOI: 10.1038/Nnano.2009.101  0.364
2009 Heller DA, Jin H, Martinez BM, Patel D, Miller BM, Yeung TK, Jena PV, Höbartner C, Ha T, Silverman SK, Strano MS. Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nature Nanotechnology. 4: 114-20. PMID 19197314 DOI: 10.1038/Nnano.2008.369  0.776
2009 Yodh JG, Stevens BC, Kanagaraj R, Janscak P, Ha T. BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation. The Embo Journal. 28: 405-16. PMID 19165145 DOI: 10.1038/Emboj.2008.298  0.429
2009 Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU, Hopfner KP, Ha T. Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science (New York, N.Y.). 323: 1070-4. PMID 19119185 DOI: 10.1126/Science.1168352  0.614
2009 Roy R, Kozlov AG, Lohman TM, Ha T. Erratum: SSB protein diffusion on single-stranded DNA stimulates RecA filament formation Nature. 462: 944-944. DOI: 10.1038/Nature08600  0.661
2009 Balci H, Arslan S, Myong S, Ha T. Structural Transitions Of a Helicase-Partial Duplex DNA Complex during ATP Hydrolysis Cycle Biophysical Journal. 96: 415a. DOI: 10.1016/J.Bpj.2008.12.2120  0.653
2009 Lee G, Hartung S, Hopfner K, Ha T. Single Molecule Study Of the RNA Degradation and Polyadenylation Activities of the Archaeal Exosome Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.1976  0.335
2009 Liu C, Shi X, Chen Y, O'Cann IK, Ha T. Single-Molecule Dynamics of the Replication Sliding Clamp and Clamp Loader System Biophysical Journal. 96: 324a. DOI: 10.1016/J.Bpj.2008.12.1625  0.508
2009 Patel S, Pandey M, Syed S, Ha T, Johnson D, Wang M. Coupling of two motors: T7 helicase-primase and DNA polymerase Biophysical Journal. 96: 193a. DOI: 10.1016/J.Bpj.2008.12.1032  0.395
2009 Jain A, Ramani B, Raghunathan K, Jena P, Xiang Y, Ha T. Single Molecule Immuno Pull Down Assay (SiMPull) for Studying Protein-Protein Interactions Biophysical Journal. 96: 25a. DOI: 10.1016/J.Bpj.2008.12.015  0.743
2008 Rothenberg E, Grimme JM, Spies M, Ha T. Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes. Proceedings of the National Academy of Sciences of the United States of America. 105: 20274-9. PMID 19074292 DOI: 10.1073/Pnas.0810317106  0.431
2008 Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 105: 16743-8. PMID 18948594 DOI: 10.1073/Pnas.0804947105  0.582
2008 Iqbal A, Arslan S, Okumus B, Wilson TJ, Giraud G, Norman DG, Ha T, Lilley DM. Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 105: 11176-81. PMID 18676615 DOI: 10.1073/Pnas.0801707105  0.757
2008 Lin Y, Lin LJ, Sriratana P, Coleman K, Ha T, Spies M, Cann IK. Engineering of functional replication protein a homologs based on insights into the evolution of oligonucleotide/oligosaccharide-binding folds. Journal of Bacteriology. 190: 5766-80. PMID 18586938 DOI: 10.1128/Jb.01930-07  0.384
2008 Yoon TY, Lu X, Diao J, Lee SM, Ha T, Shin YK. Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nature Structural & Molecular Biology. 15: 707-13. PMID 18552825 DOI: 10.1038/Nsmb.1446  0.631
2008 Cornish PV, Ermolenko DN, Noller HF, Ha T. Spontaneous Intersubunit Rotation in Single Ribosomes Molecular Cell. 30: 578-588. PMID 18538656 DOI: 10.1016/J.Molcel.2008.05.004  0.306
2008 Tang GQ, Roy R, Ha T, Patel SS. Transcription initiation in a single-subunit RNA polymerase proceeds through DNA scrunching and rotation of the N-terminal subdomains. Molecular Cell. 30: 567-77. PMID 18538655 DOI: 10.1016/J.Molcel.2008.04.003  0.779
2008 Roy R, Hohng S, Ha T. A practical guide to single-molecule FRET. Nature Methods. 5: 507-16. PMID 18511918 DOI: 10.1038/Nmeth.1208  0.773
2008 Rasnik I, Jeong YJ, McKinney SA, Rajagopal V, Patel SS, Ha T. Branch migration enzyme as a Brownian ratchet. The Embo Journal. 27: 1727-35. PMID 18511910 DOI: 10.1038/Emboj.2008.106  0.713
2008 Joo C, Balci H, Ishitsuka Y, Buranachai C, Ha T. Advances in single-molecule fluorescence methods for molecular biology. Annual Review of Biochemistry. 77: 51-76. PMID 18412538 DOI: 10.1146/Annurev.Biochem.77.070606.101543  0.593
2007 Kim HK, Rasnik I, Liu J, Ha T, Lu Y. Dissecting metal ion-dependent folding and catalysis of a single DNAzyme. Nature Chemical Biology. 3: 763-8. PMID 17965708 DOI: 10.1038/Nchembio.2007.45  0.314
2007 Hohng S, Zhou R, Nahas MK, Yu J, Schulten K, Lilley DM, Ha T. Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the holliday junction. Science (New York, N.Y.). 318: 279-83. PMID 17932299 DOI: 10.1126/Science.1146113  0.705
2007 Rothenberg E, Trakselis MA, Bell SD, Ha T. MCM forked substrate specificity involves dynamic interaction with the 5'-tail. The Journal of Biological Chemistry. 282: 34229-34. PMID 17884823 DOI: 10.1074/Jbc.M706300200  0.432
2007 Yu J, Ha T, Schulten K. How directional translocation is regulated in a DNA helicase motor. Biophysical Journal. 93: 3783-97. PMID 17704159 DOI: 10.1529/Biophysj.107.109546  0.383
2007 Myong S, Bruno MM, Pyle AM, Ha T. Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase. Science (New York, N.Y.). 317: 513-6. PMID 17656723 DOI: 10.1126/Science.1144130  0.654
2007 Ha T. Need for Speed: Mechanical Regulation of a Replicative Helicase Cell. 129: 1249-1250. PMID 17604712 DOI: 10.1016/J.Cell.2007.06.007  0.378
2007 Cisse I, Okumus B, Joo C, Ha T. Fueling protein DNA interactions inside porous nanocontainers. Proceedings of the National Academy of Sciences of the United States of America. 104: 12646-50. PMID 17563361 DOI: 10.1073/Pnas.0610673104  0.813
2007 Shirude PS, Okumus B, Ying L, Ha T, Balasubramanian S. Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit. Journal of the American Chemical Society. 129: 7484-5. PMID 17523641 DOI: 10.1021/Ja070497D  0.764
2007 Roy R, Kozlov AG, Lohman TM, Ha T. Dynamic structural rearrangements between DNA binding modes of E. coli SSB protein. Journal of Molecular Biology. 369: 1244-57. PMID 17490681 DOI: 10.1016/J.Jmb.2007.03.079  0.777
2007 Arluison V, Hohng S, Roy R, Pellegrini O, Régnier P, Ha T. Spectroscopic observation of RNA chaperone activities of Hfq in post-transcriptional regulation by a small non-coding RNA. Nucleic Acids Research. 35: 999-1006. PMID 17259214 DOI: 10.1093/Nar/Gkl1124  0.758
2007 Cornish PV, Ha T. A survey of single-molecule techniques in chemical biology. Acs Chemical Biology. 2: 53-61. PMID 17243783 DOI: 10.1021/Cb600342A  0.383
2007 Wilson TJ, Nahas M, Araki L, Harusawa S, Ha T, Lilley DM. RNA folding and the origins of catalytic activity in the hairpin ribozyme. Blood Cells, Molecules & Diseases. 38: 8-14. PMID 17150385 DOI: 10.1016/J.Bcmd.2006.10.004  0.716
2007 Cisse I, Okumus B, Joo C, Ha T. Erratum: Single-molecule chemistry and biology special feature: Fueling protein-DNA interactions inside porous nanocontainers (Proceedings of the National Academy of Sciences of the United States (July 31, 2007) 104: 31 (12646-12650) 10.1073/pnas.0610673104) Proceedings of the National Academy of Sciences of the United States of America. 104. DOI: 10.1073/Pnas.0707542104  0.791
2006 Yoon TY, Okumus B, Zhang F, Shin YK, Ha T. Multiple intermediates in SNARE-induced membrane fusion. Proceedings of the National Academy of Sciences of the United States of America. 103: 19731-6. PMID 17167056 DOI: 10.1073/Pnas.0606032103  0.759
2006 Rasnik I, McKinney SA, Ha T. Nonblinking and long-lasting single-molecule fluorescence imaging. Nature Methods. 3: 891-3. PMID 17013382 DOI: 10.1038/Nmeth934  0.701
2006 Rasnik I, Myong S, Ha T. Unraveling helicase mechanisms one molecule at a time. Nucleic Acids Research. 34: 4225-31. PMID 16935883 DOI: 10.1093/Nar/Gkl452  0.638
2006 Lin Y, Guzman CE, McKinney MC, Nair SK, Ha T, Cann IK. Methanosarcina acetivorans flap endonuclease 1 activity is inhibited by a cognate single-stranded-DNA-binding protein. Journal of Bacteriology. 188: 6153-67. PMID 16923882 DOI: 10.1128/Jb.00045-06  0.76
2006 Joo C, McKinney SA, Nakamura M, Rasnik I, Myong S, Ha T. Real-time observation of RecA filament dynamics with single monomer resolution. Cell. 126: 515-27. PMID 16901785 DOI: 10.1016/J.Cell.2006.06.042  0.825
2006 Yu J, Ha T, Schulten K. Structure-based model of the stepping motor of PcrA helicase. Biophysical Journal. 91: 2097-114. PMID 16815905 DOI: 10.1529/Biophysj.106.088203  0.4
2006 McKinney SA, Joo C, Ha T. Analysis of single-molecule FRET trajectories using hidden Markov modeling. Biophysical Journal. 91: 1941-51. PMID 16766620 DOI: 10.1529/Biophysj.106.082487  0.747
2006 Myong S, Stevens BC, Ha T. Bridging conformational dynamics and function using single-molecule spectroscopy. Structure (London, England : 1993). 14: 633-43. PMID 16615904 DOI: 10.1016/J.Str.2006.02.005  0.634
2006 Toprak E, Enderlein J, Syed S, McKinney SA, Petschek RG, Ha T, Goldman YE, Selvin PR. Defocused orientation and position imaging (DOPI) of myosin V. Proceedings of the National Academy of Sciences of the United States of America. 103: 6495-9. PMID 16614073 DOI: 10.1073/Pnas.0507134103  0.665
2006 Buranachai C, McKinney SA, Ha T. Single molecule nanometronome. Nano Letters. 6: 496-500. PMID 16522050 DOI: 10.1021/Nl052492P  0.711
2005 Lee JY, Okumus B, Kim DS, Ha T. Extreme conformational diversity in human telomeric DNA. Proceedings of the National Academy of Sciences of the United States of America. 102: 18938-43. PMID 16365301 DOI: 10.1073/Pnas.0506144102  0.753
2005 Myong S, Rasnik I, Joo C, Lohman TM, Ha T. Repetitive shuttling of a motor protein on DNA. Nature. 437: 1321-5. PMID 16251956 DOI: 10.1038/Nature04049  0.746
2005 Rasnik I, McKinney SA, Ha T. Surfaces and orientations: much to FRET about? Accounts of Chemical Research. 38: 542-8. PMID 16028888 DOI: 10.1021/Ar040138C  0.7
2005 Wilson TJ, Nahas M, Ha T, Lilley DM. Folding and catalysis of the hairpin ribozyme. Biochemical Society Transactions. 33: 461-5. PMID 15916541 DOI: 10.1042/Bst0330461  0.742
2005 Hohng S, Ha T. Single-molecule quantum-dot fluorescence resonance energy transfer. Chemphyschem. 6: 956-960. PMID 15884082 DOI: 10.1002/Cphc.200400557  0.331
2005 McKinney SA, Freeman AD, Lilley DM, Ha T. Observing spontaneous branch migration of Holliday junctions one step at a time. Proceedings of the National Academy of Sciences of the United States of America. 102: 5715-20. PMID 15824311 DOI: 10.1073/Pnas.0409328102  0.716
2005 Liu J, Déclais AC, McKinney SA, Ha T, Norman DG, Lilley DM. Stereospecific effects determine the structure of a four-way DNA junction. Chemistry & Biology. 12: 217-28. PMID 15734649 DOI: 10.1016/J.Chembiol.2004.12.006  0.694
2005 Robbins JB, McKinney MC, Guzman CE, Sriratana B, Fitz-Gibbon S, Ha T, Cann IK. The euryarchaeota, nature's medium for engineering of single-stranded DNA-binding proteins. The Journal of Biological Chemistry. 280: 15325-39. PMID 15671019 DOI: 10.1074/Jbc.M412870200  0.757
2004 Yu J, Ha T, Schulten K. Conformational model of the Holliday junction transition deduced from molecular dynamics simulations. Nucleic Acids Research. 32: 6683-95. PMID 15613597 DOI: 10.1093/Nar/Gkh1006  0.362
2004 Nahas MK, Wilson TJ, Hohng S, Jarvie K, Lilley DM, Ha T. Observation of internal cleavage and ligation reactions of a ribozyme. Nature Structural & Molecular Biology. 11: 1107-13. PMID 15475966 DOI: 10.1038/Nsmb842  0.727
2004 Okumus B, Wilson TJ, Lilley DM, Ha T. Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic. Biophysical Journal. 87: 2798-806. PMID 15454471 DOI: 10.1529/Biophysj.104.045971  0.775
2004 Hohng S, Joo C, Ha T. Single-molecule three-color FRET Biophysical Journal. 87: 1328-1337. PMID 15298935 DOI: 10.1529/Biophysj.104.043935  0.616
2004 Joo C, McKinney SA, Lilley DM, Ha T. Exploring rare conformational species and ionic effects in DNA Holliday junctions using single-molecule spectroscopy. Journal of Molecular Biology. 341: 739-51. PMID 15288783 DOI: 10.1016/J.Jmb.2004.06.024  0.766
2004 Stevens BC, Ha T. Discrete and heterogeneous rotational dynamics of single membrane probe dyes in gel phase supported lipid bilayer. The Journal of Chemical Physics. 120: 3030-9. PMID 15268450 DOI: 10.1063/1.1640349  0.342
2004 Gordon MP, Ha T, Selvin PR. Single-molecule high-resolution imaging with photobleaching. Proceedings of the National Academy of Sciences of the United States of America. 101: 6462-5. PMID 15096603 DOI: 10.1073/Pnas.0401638101  0.375
2004 Ha T. Structural dynamics and processing of nucleic acids revealed by single-molecule spectroscopy. Biochemistry. 43: 4055-63. PMID 15065847 DOI: 10.1021/Bi049973S  0.411
2004 Murphy MC, Rasnik I, Cheng W, Lohman TM, Ha T. Probing single-stranded DNA conformational flexibility using fluorescence spectroscopy. Biophysical Journal. 86: 2530-7. PMID 15041689 DOI: 10.1016/S0006-3495(04)74308-8  0.417
2004 Rasnik I, Myong S, Cheng W, Lohman TM, Ha T. DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes. Journal of Molecular Biology. 336: 395-408. PMID 14757053 DOI: 10.1016/J.Jmb.2003.12.031  0.679
2004 McKinney SA, Tan E, Wilson TJ, Nahas MK, Déclais AC, Clegg RM, Lilley DM, Ha T. Single-molecule studies of DNA and RNA four-way junctions. Biochemical Society Transactions. 32: 41-5. PMID 14748709 DOI: 10.1042/Bst0320041  0.827
2004 Hohng S, Wilson TJ, Tan E, Clegg RM, Lilley DM, Ha T. Conformational flexibility of four-way junctions in RNA. Journal of Molecular Biology. 336: 69-79. PMID 14741204 DOI: 10.1016/J.Jmb.2003.12.014  0.391
2004 Robbins JB, Murphy MC, White BA, Mackie RI, Ha T, Cann IK. Functional analysis of multiple single-stranded DNA-binding proteins from Methanosarcina acetivorans and their effects on DNA synthesis by DNA polymerase BI. The Journal of Biological Chemistry. 279: 6315-26. PMID 14676214 DOI: 10.1074/Jbc.M304491200  0.434
2004 Nahas M, Wilson TJ, Hohng S, Jarvie K, Lilley DMJ, Ha T. Erratum: Observation of internal cleavage and ligation reactions of a ribozyme Nature Structural & Molecular Biology. 11: 1253-1253. DOI: 10.1038/Nsmb1204-1253B  0.659
2003 Tan E, Wilson TJ, Nahas MK, Clegg RM, Lilley DM, Ha T. A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate. Proceedings of the National Academy of Sciences of the United States of America. 100: 9308-13. PMID 12883002 DOI: 10.1073/Pnas.1233536100  0.718
2003 Ha T, Xu J. Photodestruction intermediates probed by an adjacent reporter molecule. Physical Review Letters. 90: 223002. PMID 12857312 DOI: 10.1103/Physrevlett.90.223002  0.354
2003 Yildiz A, Forkey JN, McKinney SA, Ha T, Goldman YE, Selvin PR. Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science (New York, N.Y.). 300: 2061-5. PMID 12791999 DOI: 10.1126/Science.1084398  0.659
2003 McKinney SA, Déclais AC, Lilley DM, Ha T. Structural dynamics of individual Holliday junctions. Nature Structural Biology. 10: 93-7. PMID 12496933 DOI: 10.1038/Nsb883  0.702
2002 Johnson JM, Ha T, Chu S, Boxer SG. Early steps of supported bilayer formation probed by single vesicle fluorescence assays. Biophysical Journal. 83: 3371-9. PMID 12496104 DOI: 10.1016/S0006-3495(02)75337-X  0.491
2002 Ha T, Rasnik I, Cheng W, Babcock HP, Gauss GH, Lohman TM, Chu S. Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase. Nature. 419: 638-41. PMID 12374984 DOI: 10.1038/Nature01083  0.785
2002 Kim HD, Nienhaus GU, Ha T, Orr JW, Williamson JR, Chu S. Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules. Proceedings of the National Academy of Sciences of the United States of America. 99: 4284-9. PMID 11929999 DOI: 10.1073/Pnas.032077799  0.644
2001 Ha T. Single-molecule fluorescence resonance energy transfer. Methods (San Diego, Calif.). 25: 78-86. PMID 11558999 DOI: 10.1006/Meth.2001.1217  0.396
2001 Ha T. Single-molecule fluorescence methods for the study of nucleic acids. Current Opinion in Structural Biology. 11: 287-92. PMID 11406376 DOI: 10.1016/S0959-440X(00)00204-9  0.367
2001 Ha T, Zhuang X, Babcock H, Kim H, Orr JW, Williamson JR, Bartley L, Russell R, Herschlag D, Chu S. The Study of Single Biomolecules with Fluorescence Methods Springer Series in Chemical Physics. 67: 326-337. DOI: 10.1007/978-3-642-56544-1_19  0.736
2001 Ha T. Single-Molecule FRET Single Molecules. 2: 283-284. DOI: 10.1002/1438-5171(200112)2:4<283::Aid-Simo283>3.0.Co;2-9  0.44
2000 Zhuang X, Ha T, Kim HD, Centner T, Labeit S, Chu S. Fluorescence quenching: A tool for single-molecule protein-folding study. Proceedings of the National Academy of Sciences of the United States of America. 97: 14241-4. PMID 11121030 DOI: 10.1073/Pnas.97.26.14241  0.722
2000 Zhuang X, Bartley LE, Babcock HP, Russell R, Ha T, Herschlag D, Chu S. A single-molecule study of RNA catalysis and folding. Science (New York, N.Y.). 288: 2048-51. PMID 10856219 DOI: 10.1126/Science.288.5473.2048  0.791
1999 Ha T, Zhuang X, Kim HD, Orr JW, Williamson JR, Chu S. Ligand-induced conformational changes observed in single RNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 96: 9077-82. PMID 10430898 DOI: 10.1073/Pnas.96.16.9077  0.72
1999 Deniz AA, Dahan M, Grunwell JR, Ha T, Faulhaber AE, Chemla DS, Weiss S, Schultz PG. Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulations. Proceedings of the National Academy of Sciences of the United States of America. 96: 3670-5. PMID 10097095 DOI: 10.1073/Pnas.96.7.3670  0.687
1999 Ha T, Ting AY, Liang J, Caldwell WB, Deniz AA, Chemla DS, Schultz PG, Weiss S. Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism. Proceedings of the National Academy of Sciences of the United States of America. 96: 893-8. PMID 9927664 DOI: 10.1073/Pnas.96.3.893  0.671
1999 Banin U, Bruchez M, Alivisatos AP, Ha T, Weiss S, Chemla DS. Evidence for a thermal contribution to emission intermittency in single CdSe/CdS core/shell nanocrystals The Journal of Chemical Physics. 110: 1195-1201. DOI: 10.1063/1.478161  0.593
1999 Ha T, Laurence TA, Chemla DS, Weiss S. Polarization Spectroscopy of Single Fluorescent Molecules The Journal of Physical Chemistry B. 103: 6839-6850. DOI: 10.1021/Jp990948J  0.74
1999 Dahan M, Deniz AA, Ha T, Chemla DS, Schultz PG, Weiss S. Ratiometric measurement and identification of single diffusing molecules Chemical Physics. 247: 85-106. DOI: 10.1016/S0301-0104(99)00132-9  0.651
1998 Enderle T, Ha T, Chemla DS, Weiss S. Near-field fluorescence microscopy of cells. Ultramicroscopy. 71: 303-9. PMID 9566345 DOI: 10.1016/S0304-3991(97)00075-2  0.621
1998 Ha T, Ting A, Liang J, Glass J, Chemla D, Schultz P, Weiss S. Fluorescence spectroscopy of single molecule dynamics and its biological applications Proceedings of Spie - the International Society For Optical Engineering. 3273: 179-185. DOI: 10.1117/12.306136  0.669
1998 Ha T, Glass J, Enderle T, Chemla DS, Weiss S. Hindered Rotational Diffusion and Rotational Jumps of Single Molecules Physical Review Letters. 80: 2093-2096. DOI: 10.1103/Physrevlett.80.2093  0.638
1997 Enderle T, Ha T, Ogletree DF, Chemla DS, Magowan C, Weiss S. Membrane specific mapping and colocalization of malarial and host skeletal proteins in the Plasmodium falciparum infected erythrocyte by dual-color near-field scanning optical microscopy. Proceedings of the National Academy of Sciences of the United States of America. 94: 520-5. PMID 9012816 DOI: 10.1073/Pnas.94.2.520  0.624
1997 Ha T, Chemla DS, Enderle T, Weiss S. Single molecule spectroscopy with automated positioning Applied Physics Letters. 70: 782-784. DOI: 10.1063/1.118259  0.659
1997 Ha T, Enderle T, Chemla D, Selvin P, Weiss S. Quantum jumps of single molecules at room temperature Chemical Physics Letters. 271: 1-5. DOI: 10.1016/S0009-2614(97)00440-5  0.651
1997 Ha T, Chemla DS, Enderle T, Weiss S. Strategy for room temperature spectroscopy of single molecules Bioimaging. 5: 99-104. DOI: 10.1002/1361-6374(199709)5:3<99::Aid-Bio3>3.3.Co;2-N  0.667
1996 Ha T, Enderle T, Ogletree DF, Chemla DS, Selvin PR, Weiss S. Probing the interaction between two single molecules: Fluorescence resonance energy transfer between a single donor and a single acceptor Proceedings of the National Academy of Sciences of the United States of America. 93: 6264-6268. PMID 8692803 DOI: 10.1073/Pnas.93.13.6264  0.67
1996 Ha T, Enderle T, Chemla DS, Weiss S. Dual-molecule spectroscopy: Molecular rulers for the study of biological macromolecules Ieee Journal On Selected Topics in Quantum Electronics. 2: 1115-1128. DOI: 10.1109/2944.577342  0.662
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