Evangelia G. Kranias - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Pharmacology, Molecular Biology, Animal Physiology Biology

338 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kumar M, Haghighi K, Koch S, Rubinstein J, Stillitano F, Hajjar RJ, Kranias EG, Sadayappan S. Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy. International Journal of Molecular Sciences. 24. PMID 36768995 DOI: 10.3390/ijms24032675  0.42
2022 Rogalska ME, Vafiadaki E, Erpapazoglou Z, Haghighi K, Green L, Mantzoros CS, Hajjar RJ, Tranter M, Karakikes I, Kranias EG, Stillitano F, Kafasla P, Sanoudou D. Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts. Metabolism: Clinical and Experimental. 155344. PMID 36375644 DOI: 10.1016/j.metabol.2022.155344  0.415
2022 Vafiadaki E, Haghighi K, Arvanitis DA, Kranias EG, Sanoudou D. Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca Handling and Arrhythmogenesis. International Journal of Molecular Sciences. 23. PMID 35805951 DOI: 10.3390/ijms23136947  0.382
2021 Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, van de Leur R, Doevendans PA, Akar FG, Tranter M, ... ... Kranias EG, et al. Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. Journal of Personalized Medicine. 11. PMID 34204946 DOI: 10.3390/jpm11060502  0.411
2020 Cely-Ortiz A, Felice JI, Díaz-Zegarra LA, Valverde CA, Federico M, Palomeque J, Wehrens XHT, Kranias EG, Aiello EA, Lascano EC, Negroni JA, Mattiazzi A. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. The Journal of General Physiology. 152. PMID 32986800 DOI: 10.1085/jgp.201912512  0.38
2020 Arif M, Nabavizadeh P, Song T, Desai D, Singh R, Bazrafshan S, Kumar M, Wang Y, Gilbert RJ, Dhandapany PS, Becker RC, Kranias EG, Sadayappan S. Genetic, clinical, molecular, and pathogenic aspects of the South Asian-specific polymorphic MYBPC3 variant. Biophysical Reviews. PMID 32656747 DOI: 10.1007/S12551-020-00725-1  0.378
2020 Kumar M, Haghighi K, Kranias EG, Sadayappan S. Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis. The Journal of Biological Chemistry. PMID 32554466 DOI: 10.1074/Jbc.Ra120.013296  0.455
2020 Onusko E, McDermott MR, Robbins N, Liu G, Kranias EG, Rubinstein J, Koch SE. Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy. Plos One. 15: e0230386. PMID 32218573 DOI: 10.1371/Journal.Pone.0230386  0.376
2020 Chowdhury SAK, Warren CM, Simon JN, Ryba DM, Batra A, Varga P, Kranias EG, Tardiff JC, Solaro RJ, Wolska BM. Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response. Frontiers in Physiology. 11: 107. PMID 32210830 DOI: 10.3389/Fphys.2020.00107  0.496
2020 Meli AC, Kranias EG. Scientists on the Spot: calcium dynamics in heart function. Cardiovascular Research. PMID 32176278 DOI: 10.1093/Cvr/Cvaa031  0.362
2019 Essandoh K, Wang X, Huang W, Deng S, Gardner G, Mu X, Li Y, Kranias EG, Wang Y, Fan GC. Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy. The Journal of Biological Chemistry. PMID 31619520 DOI: 10.1074/Jbc.Ra119.008925  0.455
2019 Doevendans PA, Glijnis PC, Kranias EG. Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN). Circulation Research. 125: 720-724. PMID 31513489 DOI: 10.1161/Circresaha.119.315077  0.457
2019 Gardner GT, Travers JG, Qian J, Liu GS, Haghighi K, Robbins N, Jiang M, Li Y, Fan GC, Rubinstein J, Blaxall BC, Kranias EG. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. Jacc. Basic to Translational Science. 4: 188-199. PMID 31061921 DOI: 10.1016/J.Jacbts.2018.11.007  0.457
2019 Kumar M, Haghighi K, Kranias E, Sadayappan S. Abstract 334: Cardiac Myosin Binding Protein C Phosphorylation Regulates Calcium Homeostasis Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.334  0.404
2019 Larsen EK, Weber D, Wang S, Robia S, Kranias E, Veglia G. Intrinsically Disordered HAX-1 Regulates Phospholamban in Membranes Biophysical Journal. 116: 202a. DOI: 10.1016/J.Bpj.2018.11.1114  0.543
2018 Hof IE, van der Heijden JF, Kranias EG, Sanoudou D, de Boer RA, van Tintelen JP, van der Zwaag PA, Doevendans PA. Prevalence and cardiac phenotype of patients with a phospholamban mutation. Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation. PMID 30547415 DOI: 10.1007/S12471-018-1211-4  0.315
2018 Arvanitis DA, Vafiadaki E, Johnson DM, Kranias EG, Sanoudou D. The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity. Frontiers in Physiology. 9: 1379. PMID 30319456 DOI: 10.3389/Fphys.2018.01379  0.571
2018 Chen M, Xu D, Wu AZ, Kranias E, Lin SF, Chen PS, Chen Z. Phospholamban regulates nuclear Ca stores and inositol 1,4,5-trisphosphate mediated nuclear Ca cycling in cardiomyocytes. Journal of Molecular and Cellular Cardiology. PMID 30261161 DOI: 10.1016/J.Yjmcc.2018.09.008  0.469
2018 Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ines Ragone M, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Ablation of PLN rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovascular Research. PMID 30169578 DOI: 10.1093/Cvr/Cvy213  0.532
2018 Liu GS, Gardner G, Adly G, Jiang M, Cai WF, Lam CK, Alogaili F, Robbins N, Rubinstein J, Kranias EG. A novel human S10F-Hsp20 mutation induces lethal peripartum cardiomyopathy. Journal of Cellular and Molecular Medicine. PMID 29761889 DOI: 10.1111/Jcmm.13665  0.443
2018 Larsen EK, Olivieri C, Robia S, Kranias E, Veglia G. Intrinsically Disordered HAX-1 Regulates SERCA in a Calcium-Dependent Manner Biophysical Journal. 114: 427a. DOI: 10.1016/J.Bpj.2017.11.2368  0.574
2017 Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, ... Kranias EG, et al. HAX-1 regulates SERCA2a oxidation and degradation. Journal of Molecular and Cellular Cardiology. PMID 29169992 DOI: 10.1016/J.Yjmcc.2017.11.014  0.783
2017 Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, ... ... Kranias EG, et al. Regulation of BECN1-Mediated Autophagy by HSPB6: Insights from A Human HSPB6(S10F) Mutant. Autophagy. 1-56. PMID 29157081 DOI: 10.1080/15548627.2017.1392420  0.433
2017 Bidwell PA, Haghighi K, Kranias EG. The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart. The Journal of Biological Chemistry. PMID 29150445 DOI: 10.1074/Jbc.Ra117.000128  0.795
2017 Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, ... Kranias EG, et al. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. Journal of the American College of Cardiology. 70: 1744-1756. PMID 28958332 DOI: 10.1016/J.Jacc.2017.08.013  0.453
2017 Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, ... Kranias EG, et al. Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant. Cardiovascular Research. 113: 1403-1417. PMID 28859293 DOI: 10.1093/Cvr/Cvx113  0.413
2017 Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias EG. Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784772 DOI: 10.1073/Pnas.1706441114  0.832
2017 Kranias EG, Hajjar RJ. The Phospholamban Journey 4 Decades After Setting Out for Ithaka. Circulation Research. 120: 781-783. PMID 28254803 DOI: 10.1161/Circresaha.116.310007  0.463
2017 Bidwell P, Liu G, Nagarajan N, Haghighi K, Gardner G, Sadoshima J, Kranias E. Endogenous HAX-1 Regulates SERCA Activity and Oxidation Dependent Stability Journal of Molecular and Cellular Cardiology. 112: 144. DOI: 10.1016/J.Yjmcc.2017.07.044  0.719
2016 Stillitano F, Turnbull IC, Karakikes I, Nonnenmacher M, Backeris P, Hulot JS, Kranias EG, Hajjar RJ, Costa KD. Genomic correction of familial cardiomyopathy in human engineered cardiac tissues. European Heart Journal. PMID 27450564 DOI: 10.1093/Eurheartj/Ehw307  0.368
2016 Bidwell PA, Kranias EG. Calcium Uptake in Crude Tissue Preparation. Methods in Molecular Biology (Clifton, N.J.). 1377: 161-70. PMID 26695031 DOI: 10.1007/978-1-4939-3179-8_16  0.788
2015 Mazzocchi G, Sommese L, Palomeque J, Felice JI, Di Carlo MN, Fainstein D, Gonzalez P, Contreras P, Skapura D, McCauley MD, Lascano EC, Negroni JA, Kranias EG, Wehrens X, Valverde CA, et al. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2-S2814 site. The Journal of Physiology. PMID 26695843 DOI: 10.1113/Jp271622  0.478
2015 Lam CK, Zhao W, Liu GS, Cai WF, Gardner G, Adly G, Kranias EG. HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553996 DOI: 10.1073/Pnas.1508760112  0.374
2015 Haghighi K, Pritchard TJ, Liu GS, Singh VP, Bidwell P, Lam CK, Vafiadaki E, Das P, Ma J, Kunduri S, Sanoudou D, Florea S, Vanderbilt E, Wang HS, Rubinstein J, ... ... Kranias EG, et al. Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias. Journal of Molecular and Cellular Cardiology. PMID 26455482 DOI: 10.1016/J.Yjmcc.2015.10.004  0.839
2015 Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S. Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT. Cardiovascular Research. PMID 26410369 DOI: 10.1093/Cvr/Cvv222  0.564
2015 Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, et al. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circulation Research. PMID 26259881 DOI: 10.1161/Circresaha.115.307157  0.517
2015 Cai WF, Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. European Journal of Heart Failure. 17: 782-93. PMID 26177627 DOI: 10.1002/Ejhf.323  0.488
2015 Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, ... ... Kranias EG, et al. Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy. Nature Communications. 6: 6955. PMID 25923014 DOI: 10.1038/Ncomms7955  0.364
2015 Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A. Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway. Cardiovascular Research. 106: 432-42. PMID 25870184 DOI: 10.1093/Cvr/Cvv129  0.343
2015 Liu GS, Morales A, Vafiadaki E, Lam CK, Cai WF, Haghighi K, Adly G, Hershberger RE, Kranias EG. A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia. Cardiovascular Research. 107: 164-74. PMID 25852082 DOI: 10.1093/Cvr/Cvv127  0.513
2015 Tzimas C, Terrovitis J, Lehnart SE, Kranias EG, Sanoudou D. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 12: 1599-610. PMID 25814413 DOI: 10.1016/J.Hrthm.2015.03.043  0.542
2014 Haghighi K, Bidwell P, Kranias EG. Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend. Journal of Molecular and Cellular Cardiology. 77: 160-7. PMID 25451386 DOI: 10.1016/J.Yjmcc.2014.10.005  0.818
2014 Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, ... ... Kranias EG, et al. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 2038-45. PMID 25023328 DOI: 10.1038/Mt.2014.127  0.406
2014 Vafiadaki E, Arvanitis DA, Papalouka V, Terzis G, Roumeliotis TI, Spengos K, Garbis SD, Manta P, Kranias EG, Sanoudou D. Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation. The Febs Journal. 281: 3261-79. PMID 24860983 DOI: 10.1111/Febs.12859  0.311
2014 Mattiazzi A, Kranias EG. The role of CaMKII regulation of phospholamban activity in heart disease. Frontiers in Pharmacology. 5: 5. PMID 24550830 DOI: 10.3389/fphar.2014.00005  0.49
2014 Rubinstein J, Lasko VM, Koch SE, Singh VP, Carreira V, Robbins N, Patel AR, Jiang M, Bidwell P, Kranias EG, Jones WK, Lorenz JN. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. American Journal of Physiology. Heart and Circulatory Physiology. 306: H574-84. PMID 24322617 DOI: 10.1152/Ajpheart.00854.2013  0.8
2014 Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Tarzami ST, Kovacic JC, ... Kranias E, et al. Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells. Circulation. 129: 773-85. PMID 24249716 DOI: 10.1161/Circulationaha.113.002565  0.357
2013 Pritchard TJ, Kawase Y, Haghighi K, Anjak A, Cai W, Jiang M, Nicolaou P, Pylar G, Karakikes I, Rapti K, Rubinstein J, Hajjar RJ, Kranias EG. Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts. Plos One. 8: e80717. PMID 24312496 DOI: 10.1371/Journal.Pone.0080717  0.533
2013 Vafiadaki E, Arvanitis DA, Sanoudou D, Kranias EG. Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation. Plos One. 8: e80867. PMID 24244723 DOI: 10.1371/Journal.Pone.0080867  0.42
2013 Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim do H, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, ... Kranias EG, et al. Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein. Journal of the American Heart Association. 2: e000460. PMID 24125847 DOI: 10.1161/Jaha.113.000460  0.559
2013 Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, et al. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxidants & Redox Signaling. 19: 1185-97. PMID 23919584 DOI: 10.1089/Ars.2012.5057  0.566
2013 Maiellaro-Rafferty K, Wansapura JP, Mendsaikhan U, Osinska H, James JF, Taylor MD, Robbins J, Kranias EG, Towbin JA, Purevjav E. Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 60: 151-60. PMID 23632046 DOI: 10.1016/J.Yjmcc.2013.04.021  0.43
2013 Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, ... Kranias EG, et al. Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. Basic Research in Cardiology. 108: 344. PMID 23553082 DOI: 10.1007/S00395-013-0344-2  0.535
2013 Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ. AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circulation. Heart Failure. 6: 310-7. PMID 23271792 DOI: 10.1161/Circheartfailure.112.971325  0.522
2013 Lam CK, Zhao W, Cai W, Vafiadaki E, Florea SM, Ren X, Liu Y, Robbins N, Zhang Z, Zhou X, Jiang M, Rubinstein J, Jones WK, Kranias EG. Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation Research. 112: 79-89. PMID 22982986 DOI: 10.1161/Circresaha.112.279935  0.43
2012 Park CS, Cha H, Kwon EJ, Jeong D, Hajjar RJ, Kranias EG, Cho C, Park WJ, Kim DH. AAV-Mediated Knock-Down of HRC Exacerbates Transverse Aorta Constriction-Induced Heart Failure Plos One. 7. PMID 22952658 DOI: 10.1371/Journal.Pone.0043282  0.59
2012 Florea S, Anjak A, Cai WF, Qian J, Vafiadaki E, Figueria S, Haghighi K, Rubinstein J, Lorenz J, Kranias EG. Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Basic Research in Cardiology. 107: 279. PMID 22777184 DOI: 10.1007/S00395-012-0279-Z  0.547
2012 Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. Plos One. 7: e39962. PMID 22768324 DOI: 10.1371/Journal.Pone.0039962  0.464
2012 Kranias EG, Hajjar RJ. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circulation Research. 110: 1646-60. PMID 22679139 DOI: 10.1161/Circresaha.111.259754  0.551
2012 Zhang X, Wang X, Zhu H, Kranias EG, Tang Y, Peng T, Chang J, Fan GC. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. Plos One. 7: e32765. PMID 22427880 DOI: 10.1371/Journal.Pone.0032765  0.342
2012 Cai WF, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovascular Research. 94: 333-41. PMID 22411973 DOI: 10.1093/Cvr/Cvs119  0.482
2012 Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers DM, Kranias EG. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of Molecular and Cellular Cardiology. 52: 773-82. PMID 22155237 DOI: 10.1016/J.Yjmcc.2011.11.012  0.56
2012 Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1009-17. PMID 22090316 DOI: 10.1096/Fj.11-194027  0.457
2012 Boncompagni S, Thomas M, Lopez JR, Allen PD, Kranias EG, Franzini-Armstrong C, Perez CF. Null Mutations for Triadin and Junctin Reveal Triadin Anchors and the Requirement for Triadin-Junctin-CASQ Complexes in Stablizing RyR Resting Leak Biophysical Journal. 102: 363a. DOI: 10.1016/J.Bpj.2011.11.1983  0.446
2012 Pritchard TJ, Edes I, Kranias EG. Ca2+-ATPases Cell Physiology Source Book. 179-194. DOI: 10.1016/B978-0-12-387738-3.00013-5  0.313
2011 Altschafl BA, Arvanitis DA, Fuentes O, Yuan Q, Kranias EG, Valdivia HH. Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. The Journal of Physiology. 589: 6063-80. PMID 22025663 DOI: 10.1113/Jphysiol.2011.215988  0.502
2011 Gaffin RD, Peña JR, Alves MS, Dias FA, Chowdhury SA, Heinrich LS, Goldspink PH, Kranias EG, Wieczorek DF, Wolska BM. Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein. Journal of Molecular and Cellular Cardiology. 51: 812-20. PMID 21840315 DOI: 10.1016/J.Yjmcc.2011.07.026  0.39
2011 Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh VP, Chen S, Zhang H, Zhang R, Cheng H, Kranias EG. Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1588-95. PMID 21742996 DOI: 10.1152/Ajpheart.01153.2010  0.531
2011 Qian J, Vafiadaki E, Florea SM, Singh VP, Song W, Lam CK, Wang Y, Yuan Q, Pritchard TJ, Cai W, Haghighi K, Rodriguez P, Wang HS, Sanoudou D, Fan GC, ... Kranias EG, et al. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circulation Research. 108: 1429-38. PMID 21493896 DOI: 10.1161/Circresaha.110.237644  0.496
2011 Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of Clinical Investigation. 121: 1044-52. PMID 21285509 DOI: 10.1172/Jci43844  0.445
2011 Wang HS, Arvanitis DA, Dong M, Niklewski PJ, Zhao W, Lam CK, Kranias EG, Sanoudou D. SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts. Physiological Genomics. 43: 357-64. PMID 21266500 DOI: 10.1152/Physiolgenomics.00032.2010  0.544
2011 Mattiazzi A, Kranias EG. CaMKII regulation of phospholamban and SR Ca2+ load. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 784-7. PMID 21111063 DOI: 10.1016/J.Hrthm.2010.11.035  0.539
2011 Fan GC, Kranias EG. Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. Journal of Molecular and Cellular Cardiology. 51: 574-7. PMID 20869365 DOI: 10.1016/J.Yjmcc.2010.09.013  0.423
2011 Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG. Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling. Journal of Molecular and Cellular Cardiology. 50: 43-9. PMID 20807542 DOI: 10.1016/J.Yjmcc.2010.08.021  0.528
2011 Vafiadaki E, Lam CK, Zhao W, Arvanitis DA, Sanoudou D, Kontrogianni-Konstantopoulos A, Kranias EG. 21 HAX-1: a mitochondrial anti-apoptotic protein with emerging roles in cardiac muscle Heart. 97: e8-e8. DOI: 10.1136/Heartjnl-2011-301156.21  0.554
2010 Chen G, Zhou X, Florea S, Qian J, Cai W, Zhang Z, Fan GC, Lorenz J, Hajjar RJ, Kranias EG. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic Research in Cardiology. 105: 573-81. PMID 20512582 DOI: 10.1007/S00395-010-0106-3  0.419
2010 Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM, Lipskaia L, Hajjar RJ. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells Molecular Therapy. 18: 1284-1292. PMID 20461063 DOI: 10.1038/Mt.2010.77  0.368
2010 Vafiadaki E, Arvanitis DA, Kranias EG, Sanoudou D. Pharmacogenetically tailored treatments for heart disease. Current Pharmaceutical Design. 16: 2194-213. PMID 20459385 DOI: 10.2174/138161210791792796  0.309
2010 Lompré AM, Hajjar RJ, Harding SE, Kranias EG, Lohse MJ, Marks AR. Ca2+ cycling and new therapeutic approaches for heart failure. Circulation. 121: 822-30. PMID 20124124 DOI: 10.1161/Circulationaha.109.890954  0.496
2010 Salas MA, Valverde CA, Sánchez G, Said M, Rodriguez JS, Portiansky EL, Kaetzel MA, Dedman JR, Donoso P, Kranias EG, Mattiazzi A. The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 48: 1298-306. PMID 20060004 DOI: 10.1016/J.Yjmcc.2009.12.015  0.485
2010 Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circulation Research. 106: 354-62. PMID 19959778 DOI: 10.1161/Circresaha.109.207423  0.525
2010 Paolocci N, Tocchetti CG, Mahaney JE, Keceli G, Lee DI, Ballin JD, Farrance IK, Kranias E, Gao WD, Wilson GM, Kass DA, Toscano JP. Nitroxyl and “Forbidden Disulfides”: Phospholamban Cysteines are Targeted to Enhance SERCA2a Activity Biophysical Journal. 98: 763a. DOI: 10.1016/J.Bpj.2009.12.4189  0.457
2009 Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG. The anti-apoptotic protein HAX-1 is a regulator of cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 106: 20776-81. PMID 19920172 DOI: 10.1073/Pnas.0906998106  0.687
2009 Qian J, Ren X, Wang X, Zhang P, Jones WK, Molkentin JD, Fan GC, Kranias EG. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation Research. 105: 1223-31. PMID 19850943 DOI: 10.1161/Circresaha.109.200378  0.403
2009 Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, Fan GC. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells (Dayton, Ohio). 27: 3021-31. PMID 19816949 DOI: 10.1002/Stem.230  0.309
2009 Jones WK, Fan GC, Liao S, Zhang JM, Wang Y, Weintraub NL, Kranias EG, Schultz JE, Lorenz J, Ren X. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation. 120: S1-9. PMID 19752352 DOI: 10.1161/Circulationaha.108.843938  0.309
2009 Papalouka V, Arvanitis DA, Vafiadaki E, Mavroidis M, Papadodima SA, Spiliopoulou CA, Kremastinos DT, Kranias EG, Sanoudou D. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Molecular and Cellular Biology. 29: 6046-58. PMID 19752190 DOI: 10.1128/Mcb.00654-09  0.391
2009 Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation Research. 105: 194-200. PMID 19556521 DOI: 10.1161/Circresaha.109.195313  0.514
2009 Wang X, Zingarelli B, O'Connor M, Zhang P, Adeyemo A, Kranias EG, Wang Y, Fan GC. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. Journal of Molecular and Cellular Cardiology. 47: 382-90. PMID 19501592 DOI: 10.1016/J.Yjmcc.2009.05.016  0.362
2009 Nicolaou P, Hajjar RJ, Kranias EG. Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology. Journal of Molecular and Cellular Cardiology. 47: 365-71. PMID 19481088 DOI: 10.1016/J.Yjmcc.2009.05.010  0.52
2009 Pritchard TJ, Kranias EG. Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis. The Journal of Physiology. 587: 3125-33. PMID 19403607 DOI: 10.1113/Jphysiol.2009.172171  0.527
2009 Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S, Mitton B, Pathak A, Robbins J, Hajjar RJ, Jones K, Kranias EG. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation Research. 104: 1012-20. PMID 19299645 DOI: 10.1161/Circresaha.108.189811  0.517
2009 Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1484-90. PMID 19286959 DOI: 10.1152/Ajpheart.00229.2008  0.582
2009 Nicolaou P, Kranias EG. Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology. Frontiers in Bioscience (Landmark Edition). 14: 3571-85. PMID 19273294 DOI: 10.2741/3472  0.553
2009 Waggoner JR, Ginsburg KS, Mitton B, Haghighi K, Robbins J, Bers DM, Kranias EG. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport. American Journal of Physiology. Heart and Circulatory Physiology. 296: H698-703. PMID 19112098 DOI: 10.1152/Ajpheart.00272.2008  0.547
2009 Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. The Journal of Clinical Investigation. 119: 203-12. PMID 19065046 DOI: 10.1172/Jci36445  0.37
2009 Zhao W, Fan GC, Zhang ZG, Bandyopadhyay A, Zhou X, Kranias EG. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic Research in Cardiology. 104: 377-89. PMID 19030911 DOI: 10.1007/S00395-008-0764-6  0.34
2009 Vafiadaki E, Arvanitis DA, Pagakis SN, Papalouka V, Sanoudou D, Kontrogianni-Konstantopoulos A, Kranias EG. The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Molecular Biology of the Cell. 20: 306-18. PMID 18971376 DOI: 10.1091/Mbc.E08-06-0587  0.458
2009 Chen G, Zhou X, Pathak A, Dorn GW, Kranias EG. The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure. Cardiology. 112: 224-31. PMID 18698139 DOI: 10.1159/000151240  0.371
2009 Vafiadaki E, Papalouka V, Arvanitis DA, Kranias EG, Sanoudou D. The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate. PflüGers Archiv : European Journal of Physiology. 457: 687-700. PMID 18415121 DOI: 10.1007/S00424-008-0506-5  0.524
2009 Tocchetti CG, Froehlich JP, Mahaney JE, Wilson G, Ballin JD, Kohr MJ, Kaludercic N, Vecoli C, Kranias EG, Ziolo MT, Kass DA, Paolocci N. Nitroxyl (HNO) Modifies Cysteine Residues in Phospholamban to Increase Myocyte Ca2+-Cycling and Contractility Biophysical Journal. 96: 515a-516a. DOI: 10.1016/J.Bpj.2008.12.2655  0.529
2008 Fan GC, Zhou X, Wang X, Song G, Qian J, Nicolaou P, Chen G, Ren X, Kranias EG. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation Research. 103: 1270-9. PMID 18948619 DOI: 10.1161/Circresaha.108.182832  0.405
2008 Nicolaou P, Knöll R, Haghighi K, Fan GC, Dorn GW, Hasenfub G, Kranias EG. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of Biological Chemistry. 283: 33465-71. PMID 18790732 DOI: 10.1074/Jbc.M802307200  0.35
2008 Arvanitis DA, Sanoudou D, Kolokathis F, Vafiadaki E, Papalouka V, Kontrogianni-Konstantopoulos A, Theodorakis GN, Paraskevaidis IA, Adamopoulos S, Dorn GW, Kremastinos DT, Kranias EG. The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy. European Heart Journal. 29: 2514-25. PMID 18617481 DOI: 10.1093/Eurheartj/Ehn328  0.33
2008 Mandel F, Kranias EG, Schwartz A. The effect of cAMP-dependent protein kinase phosphorylation on the external Ca2+ binding sites of cardiac sarcoplasmic reticulum. Journal of Bioenergetics and Biomembranes. 15: 179-94. PMID 18251105 DOI: 10.1007/Bf00743939  0.483
2008 Haghighi K, Chen G, Sato Y, Fan GC, He S, Kolokathis F, Pater L, Paraskevaidis I, Jones WK, Dorn GW, Kremastinos DT, Kranias EG. A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids. Human Mutation. 29: 640-7. PMID 18241046 DOI: 10.1002/Humu.20692  0.477
2008 Fan GC, Yuan Q, Kranias EG. Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function. Trends in Cardiovascular Medicine. 18: 1-5. PMID 18206802 DOI: 10.1016/J.Tcm.2007.10.002  0.573
2008 Chen G, Zhou X, Nicolaou P, Rodriguez P, Song G, Mitton B, Pathak A, Zachariah A, Fan GC, Dorn GW, Kranias EG. A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1790-6. PMID 18192322 DOI: 10.1096/Fj.07-097428  0.462
2008 Zhang YH, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circulation Research. 102: 242-9. PMID 18007024 DOI: 10.1161/Circresaha.107.164798  0.513
2008 Pattison JS, Waggoner JR, James J, Martin L, Gulick J, Osinska H, Klevitsky R, Kranias EG, Robbins J. Phospholamban overexpression in transgenic rabbits. Transgenic Research. 17: 157-70. PMID 17882530 DOI: 10.1007/S11248-007-9139-2  0.496
2008 Arvanitis D, Dong M, Zhao W, Vafiadaki E, Kranias E, Wang H, Sanoudou D. Analysis of a “humanized” phospholamban mouse model reveals new pathways linking Ca2+ cycling and cardiac electrophysiology Journal of Molecular and Cellular Cardiology. 44: 743-744. DOI: 10.1016/J.Yjmcc.2008.02.079  0.492
2007 Kranias EG, Bers DM. Calcium and cardiomyopathies Sub-Cellular Biochemistry. 45: 523-537. PMID 18193651 DOI: 10.1007/978-1-4020-6191-2_20  0.549
2007 Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V. Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. Plos One. 2: e1051. PMID 17940615 DOI: 10.1371/Journal.Pone.0001051  0.349
2007 Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. American Journal of Physiology. Heart and Circulatory Physiology. 293: H1581-9. PMID 17526652 DOI: 10.1152/Ajpheart.00278.2007  0.524
2007 Zhou X, Fan GC, Ren X, Waggoner JR, Gregory KN, Chen G, Jones WK, Kranias EG. Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. Cardiovascular Research. 75: 487-97. PMID 17499229 DOI: 10.1016/J.Cardiores.2007.04.005  0.511
2007 Rodriguez P, Mitton B, Nicolaou P, Chen G, Kranias EG. Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 293: H762-9. PMID 17416610 DOI: 10.1152/Ajpheart.00104.2007  0.427
2007 Pathak A, Baldwin B, Kranias EG. Key protein alterations associated with hyperdynamic cardiac function: insights based on proteomic analysis of the protein phosphatase 1 inhibitor-1 overexpressing hearts. Hellenic Journal of Cardiology : Hjc = HellēNikē Kardiologikē EpitheōRēSĒ. 48: 30-6. PMID 17388107  0.372
2007 Vafiadaki E, Sanoudou D, Arvanitis DA, Catino DH, Kranias EG, Kontrogianni-Konstantopoulos A. Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function. Journal of Molecular Biology. 367: 65-79. PMID 17241641 DOI: 10.1016/J.Jmb.2006.10.057  0.481
2007 Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang HS, Valdivia HH, ... ... Kranias EG, et al. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation. 115: 300-9. PMID 17224479 DOI: 10.1161/Circulationaha.106.654699  0.577
2007 Vila-Petroff M, Salas MA, Said M, Valverde CA, Sapia L, Portiansky E, Hajjar RJ, Kranias EG, Mundiña-Weilenmann C, Mattiazzi A. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovascular Research. 73: 689-98. PMID 17217936 DOI: 10.1016/J.Cardiores.2006.12.003  0.408
2007 Fan GC, Yuan Q, Zhao W, Chu G, Kranias EG. Junctin is a prominent regulator of contractility in cardiomyocytes. Biochemical and Biophysical Research Communications. 352: 617-22. PMID 17150191 DOI: 10.1016/J.Bbrc.2006.11.093  0.489
2006 Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation Research. 99: 1233-42. PMID 17068291 DOI: 10.1161/01.Res.0000251074.19348.Af  0.442
2006 Rodriguez P, Mitton B, Waggoner JR, Kranias EG. Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function. The Journal of Biological Chemistry. 281: 38599-608. PMID 17046826 DOI: 10.1074/Jbc.M604139200  0.44
2006 Chu G, Kranias EG. Phospholamban as a therapeutic modality in heart failure. Novartis Foundation Symposium. 274: 156-71; discussion 1. PMID 17019811 DOI: 10.1002/0470029331.Ch10  0.569
2006 McGraw DW, Fogel KM, Kong S, Litonjua AA, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological Genomics. 27: 171-7. PMID 16849635 DOI: 10.1152/Physiolgenomics.00044.2006  0.346
2006 Vangheluwe P, Tjwa M, Van Den Bergh A, Louch WE, Beullens M, Dode L, Carmeliet P, Kranias E, Herijgers P, Sipido KR, Raeymaekers L, Wuytack F. A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span. Journal of Molecular and Cellular Cardiology. 41: 308-17. PMID 16814319 DOI: 10.1016/J.Yjmcc.2006.05.014  0.556
2006 Mattiazzi A, Mundiña-Weilenmann C, Vittone L, Said M, Kranias EG. The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas. 39: 563-72. PMID 16648892 DOI: 10.1590/S0100-879X2006000500001  0.501
2006 Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA, Mitton BA, Waggoner JR, Del Monte F, Park WJ, Dorn GW, Bers DM, Kranias EG. Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. Journal of Molecular and Cellular Cardiology. 40: 653-65. PMID 16600288 DOI: 10.1016/J.Yjmcc.2006.02.003  0.803
2006 Valverde CA, Mundiña-Weilenmann C, Reyes M, Kranias EG, Escobar AL, Mattiazzi A. Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart. Cardiovascular Research. 70: 335-45. PMID 16516179 DOI: 10.1016/J.Cardiores.2006.01.018  0.491
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Kranias EG, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/Circulationaha.105.583351  0.542
2006 Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 103: 2446-51. PMID 16461894 DOI: 10.1073/Pnas.0510883103  0.527
2006 Haghighi K, Kolokathis F, Gramolini AO, Waggoner JR, Pater L, Lynch RA, Fan GC, Tsiapras D, Parekh RR, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 103: 1388-93. PMID 16432188 DOI: 10.1073/Pnas.0510519103  0.541
2006 Wu Y, Shintani A, Grueter C, Zhang R, Hou Y, Yang J, Kranias EG, Colbran RJ, Anderson ME. Suppression of dynamic Ca(2+) transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition. Journal of Molecular and Cellular Cardiology. 40: 213-23. PMID 16413575 DOI: 10.1016/J.Yjmcc.2005.11.005  0.5
2006 Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers DM, Dedman JR. Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. American Journal of Physiology. Heart and Circulatory Physiology. 290: H599-606. PMID 16143658 DOI: 10.1152/Ajpheart.00214.2005  0.582
2005 Waggoner JR, Kranias EG. Role of phospholamban in the pathogenesis of heart failure. Heart Failure Clinics. 1: 207-18. PMID 17386847 DOI: 10.1016/J.Hfc.2005.03.008  0.432
2005 Rodriguez P, Mitton B, Kranias EG. Phosphorylation of glutathione-S-transferase by protein kinase C-alpha implications for affinity-tag purification. Biotechnology Letters. 27: 1869-73. PMID 16328982 DOI: 10.1007/S10529-005-3895-Y  0.313
2005 Mattiazzi A, Mundiña-Weilenmann C, Guoxiang C, Vittone L, Kranias E. Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditions. Cardiovascular Research. 68: 366-75. PMID 16226237 DOI: 10.1016/J.Cardiores.2005.08.010  0.566
2005 Fan GC, Chu G, Kranias EG. Hsp20 and its cardioprotection. Trends in Cardiovascular Medicine. 15: 138-41. PMID 16099377 DOI: 10.1016/J.Tcm.2005.05.004  0.387
2005 Sanoudou D, Vafiadaki E, Arvanitis DA, Kranias E, Kontrogianni-Konstantopoulos A. Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies. Physiological Genomics. 21: 131-43. PMID 15831843 DOI: 10.1152/Physiolgenomics.00259.2004  0.348
2005 Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, ... ... Kranias EG, et al. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation Research. 96: 756-66. PMID 15746443 DOI: 10.1161/01.Res.0000161256.85833.Fa  0.672
2004 Sutliff RL, Conforti L, Weber CS, Kranias EG, Paul RJ. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse. Vascular Pharmacology. 41: 197-204. PMID 15653095 DOI: 10.1016/J.Vph.2004.11.004  0.359
2004 Szentesi P, Pignier C, Egger M, Kranias EG, Niggli E. Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circulation Research. 95: 807-13. PMID 15388639 DOI: 10.1161/01.Res.0000146029.80463.7D  0.47
2004 Chu G, Kerr JP, Mitton B, Egnaczyk GF, Vazquez JA, Shen M, Kilby GW, Stevenson TI, Maggio JE, Vockley J, Rapundalo ST, Kranias EG. Proteomic analysis of hyperdynamic mouse hearts with enhanced sarcoplasmic reticulum calcium cycling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1725-7. PMID 15358683 DOI: 10.1096/Fj.04-2025Fje  0.542
2004 Haghighi K, Gregory KN, Kranias EG. Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy. Biochemical and Biophysical Research Communications. 322: 1214-22. PMID 15336969 DOI: 10.1016/J.Bbrc.2004.07.164  0.547
2004 Zhao W, Uehara Y, Chu G, Song Q, Qian J, Young K, Kranias EG. Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility. Journal of Molecular and Cellular Cardiology. 37: 607-12. PMID 15276030 DOI: 10.1016/J.Yjmcc.2004.05.013  0.744
2004 Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG. Regulation of myocardial function by histidine-rich, calcium-binding protein. American Journal of Physiology. Heart and Circulatory Physiology. 287: H1705-11. PMID 15191886 DOI: 10.1152/Ajpheart.01211.2003  0.544
2004 Janczewski AM, Zahid M, Lemster BH, Frye CS, Gibson G, Higuchi Y, Kranias EG, Feldman AM, McTiernan CF. Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model. Cardiovascular Research. 62: 468-80. PMID 15158139 DOI: 10.1016/J.Cardiores.2004.02.006  0.475
2004 Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circulation Research. 94: 1474-82. PMID 15105294 DOI: 10.1161/01.Res.0000129179.66631.00  0.744
2004 Song Q, Young KB, Chu G, Gulick J, Gerst M, Grupp IL, Robbins J, Kranias EG. Overexpression of phospholamban in slow-twitch skeletal muscle is associated with depressed contractile function and muscle remodeling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 974-6. PMID 15059971 DOI: 10.1096/Fj.03-1058Fje  0.735
2004 Pan Y, Kislinger T, Gramolini AO, Zvaritch E, Kranias EG, MacLennan DH, Emili A. Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics. Proceedings of the National Academy of Sciences of the United States of America. 101: 2241-6. PMID 14982994 DOI: 10.1073/Pnas.0308174101  0.532
2004 Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 109: 1154-60. PMID 14967726 DOI: 10.1161/01.Cir.0000117254.68497.39  0.42
2004 Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, ... ... Kranias EG, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/Nm1000  0.535
2004 Yatani A, Kim SJ, Kudej RK, Wang Q, Depre C, Irie K, Kranias EG, Vatner SF, Vatner DE. Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. American Journal of Physiology. Heart and Circulatory Physiology. 286: H2219-28. PMID 14962828 DOI: 10.1152/Ajpheart.01096.2003  0.416
2004 Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Dorn GW, Kranias EG. Increased particulate partitioning of PKCε reverses susceptibility of phospholamban knockout hearts to ischemic injury Journal of Molecular and Cellular Cardiology. 36: 313-318. PMID 14871559 DOI: 10.1016/J.Yjmcc.2003.12.001  0.51
2004 Chu G, Egnaczyk GF, Zhao W, Jo SH, Fan GC, Maggio JE, Xiao RP, Kranias EG. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circulation Research. 94: 184-93. PMID 14615292 DOI: 10.1161/01.Res.0000107198.90218.21  0.419
2003 MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nature Reviews. Molecular Cell Biology. 4: 566-77. PMID 12838339 DOI: 10.1038/Nrm1151  0.503
2003 Schmidt AG, Haghighi K, Frank B, Pater L, Dorn GW, Walsh RA, Kranias EG. Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure. Journal of Molecular and Cellular Cardiology. 35: 867-70. PMID 12818578 DOI: 10.1016/S0022-2828(03)00111-1  0.413
2003 Said M, Vittone L, Mundina-Weilenmann C, Ferrero P, Kranias EG, Mattiazzi A. Role of dual-site phospholamban phosphorylation in the stunned heart: insights from phospholamban site-specific mutants. American Journal of Physiology. Heart and Circulatory Physiology. 285: H1198-205. PMID 12763747 DOI: 10.1152/Ajpheart.00209.2003  0.463
2003 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of Clinical Investigation. 111: 869-76. PMID 12639993 DOI: 10.1172/Jci17892  0.494
2003 Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. The Journal of Clinical Investigation. 111: 859-67. PMID 12639992 DOI: 10.1172/Jci16738  0.833
2003 Brittsan AG, Ginsburg KS, Chu G, Yatani A, Wolska BM, Schmidt AG, Asahi M, MacLennan DH, Bers DM, Kranias EG. Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport. Circulation Research. 92: 769-76. PMID 12637367 DOI: 10.1161/01.Res.0000066661.49920.59  0.837
2003 Dash R, Schmidt AG, Pathak A, Gerst MJ, Biniakiewicz D, Kadambi VJ, Hoit BD, Abraham WT, Kranias EG. Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovascular Research. 57: 704-14. PMID 12618232 DOI: 10.1016/S0008-6363(02)00772-1  0.664
2003 Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (New York, N.Y.). 299: 1410-3. PMID 12610310 DOI: 10.1126/Science.1081578  0.482
2003 Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG, Depaoli-Roach AA, Sassone-Corsi P, Kass DA. Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 144-51. PMID 12554693 DOI: 10.1096/Fj.01-0981Com  0.463
2003 Zhao W, Frank KF, Chu G, Gerst MJ, Schmidt AG, Ji Y, Periasamy M, Kranias EG. Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state. Cardiovascular Research. 57: 71-81. PMID 12504816 DOI: 10.1016/S0008-6363(02)00609-0  0.45
2003 Paul RJ, Nobe K, Kranias E, Shull G, Lingrel J. PMCA, SERCA and Na, K ATPase Alpha Isoforms and Ca2+ Homeostasis in Smooth Muscle Evidence from Gene-Altered Mice Journal of Smooth Muscle Research Japanese Section. 7: J1-J35. DOI: 10.1540/Heikatsukinzashi1997.7.J1  0.369
2003 Sato Y, Schmidt AG, Kiriazis H, Hoit BD, Kranias EG. Molecular and Cellular Biochemistry. 242: 19-25. DOI: 10.1023/A:1021196402952  0.406
2003 ENGELHARDT S, HEIN L, KRANIAS E, LOHSE M. 682 Phospholamban is critically involved in beta-adrenergic receptor induced cardiac hypertrophy and failure European Journal of Heart Failure Supplements. 2: 140-141. DOI: 10.1016/S1567-4215(03)90427-9  0.383
2003 Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Kranias EG, Dorn GW. Perpetual preconditioning by PKCε reverses susceptibility of phospholamban deficient hearts to ischemic injury Journal of Cardiac Failure. 9: S14. DOI: 10.1016/S1071-9164(03)00269-0  0.5
2003 Pathak A, Zhao W, Fan G, Andrew CN, Hahn H, Ping L, Syed F, Colbert M, DePaoli-Roach AA, del Monte F, Hajjar R, Kranias EG. The protein phosphatase 1 inhibitor-1: a potent “molecular inotrope” in cardiac function Journal of Cardiac Failure. 9: S13. DOI: 10.1016/S1071-9164(03)00255-0  0.417
2003 Fan G, Gregory KN, Zhao W, Park WJ, Kranias EG. HRC overexpression impairs SR Ca2+ cycling by upregulation of junctin and triadin Journal of Cardiac Failure. 9: S13. DOI: 10.1016/S1071-9164(03)00249-5  0.371
2003 Zhao W, Yuan Q, Pathak A, Chu G, Hahn HS, Marreez Y, Syed F, Dorn GW, Kranias EG. Human phospholamban: a superinhibitor of cardiac function Journal of Cardiac Failure. 9: S3. DOI: 10.1016/S1071-9164(03)00152-0  0.391
2002 Chu G, Haghighi K, Kranias EG. From mouse to man: Understanding heart failure through genetically altered mouse models Journal of Cardiac Failure. 8. PMID 12555156 DOI: 10.1054/Jcaf.2002.129284  0.448
2002 Brixius K, Savvidou-Zaroti P, Mehlhorn U, Bloch W, Kranias EG, Schwinger RH. Increased Ca2+-sensitivity of myofibrillar tension in heart failure and its functional implication. Basic Research in Cardiology. I111-7. PMID 12479244 DOI: 10.1007/S003950200039  0.538
2002 Frank KF, Bölck B, Brixius K, Kranias EG, Schwinger RH. Modulation of SERCA: implications for the failing human heart. Basic Research in Cardiology. 97: I72-8. PMID 12479238 DOI: 10.1007/S003950200033  0.525
2002 Chu G, Kranias EG. Functional interplay between dual site phospholambam phosphorylation: insights from genetically altered mouse models. Basic Research in Cardiology. I43-8. PMID 12479233 DOI: 10.1007/S003950200028  0.515
2002 Schmidt AG, Zhai J, Carr AN, Gerst MJ, Lorenz JN, Pollesello P, Annila A, Hoit BD, Kranias EG. Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure. Cardiovascular Research. 56: 248-59. PMID 12393095 DOI: 10.1016/S0008-6363(02)00541-2  0.645
2002 Cross HR, Kranias EG, Murphy E, Steenbergen C. Ablation of PLB exacerbates ischemic injury to a lesser extent in female than male mice: protective role of NO. American Journal of Physiology. Heart and Circulatory Physiology. 284: H683-90. PMID 12388218 DOI: 10.1152/Ajpheart.00567.2002  0.379
2002 Schmidt AG, Gerst M, Zhai J, Carr AN, Pater L, Kranias EG, Hoit BD. Evaluation of left ventricular diastolic function from spectral and color M-mode Doppler in genetically altered mice. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. 15: 1065-73. PMID 12373248 DOI: 10.1067/Mje.2002.121863  0.569
2002 Carr AN, Kranias EG. Thyroid hormone regulation of calcium cycling proteins. Thyroid : Official Journal of the American Thyroid Association. 12: 453-7. PMID 12165106 DOI: 10.1089/105072502760143818  0.653
2002 Paul RJ, Shull GE, Kranias EG. The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice. Novartis Foundation Symposium. 246: 228-38; discussion 2. PMID 12164311 DOI: 10.1002/0470853050.Ch17  0.448
2002 Chu G, Carr AN, Young KB, Lester JW, Yatani A, Sanbe A, Colbert MC, Schwartz SM, Frank KF, Lampe PD, Robbins J, Molkentin JD, Kranias EG. Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. Cardiovascular Research. 54: 105-16. PMID 12062367 DOI: 10.1016/S0008-6363(02)00230-4  0.704
2002 Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, ... Kranias EG, et al. Type 1 phosphatase, a negative regulator of cardiac function. Molecular and Cellular Biology. 22: 4124-35. PMID 12024026 DOI: 10.1128/Mcb.22.12.4124-4135.2002  0.65
2002 Wolska BM, Arteaga GM, Peña JR, Nowak G, Phillips RM, Sahai S, de Tombe PP, Martin AF, Kranias EG, Solaro RJ. Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation. Circulation Research. 90: 882-8. PMID 11988489 DOI: 10.1161/01.Res.0000016962.36404.04  0.391
2002 Pi Y, Kemnitz KR, Zhang D, Kranias EG, Walker JW. Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice. Circulation Research. 90: 649-56. PMID 11934831 DOI: 10.1161/01.Res.0000014080.82861.5F  0.447
2002 Li Y, Kranias EG, Mignery GA, Bers DM. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circulation Research. 90: 309-16. PMID 11861420 DOI: 10.1161/Hh0302.105660  0.543
2002 Kiriazis H, Sato Y, Kadambi VJ, Schmidt AG, Gerst MJ, Hoit BD, Kranias EG. Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis. Cardiovascular Research. 53: 372-81. PMID 11827688 DOI: 10.1016/S0008-6363(01)00487-4  0.376
2001 Schmidt AG, Edes I, Kranias EG. Phospholamban: a promising therapeutic target in heart failure? Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 15: 387-96. PMID 11855657 DOI: 10.1023/A:1013381204658  0.524
2001 Frank KF, Mesnard-Rouiller L, Chu G, Young KB, Zhao W, Haghighi K, Sato Y, Kranias EG. Structure and expression of the mouse cardiac calsequestrin gene. Basic Research in Cardiology. 96: 636-44. PMID 11770083 DOI: 10.1007/S003950170016  0.473
2001 Nobe K, Sutliff RL, Kranias EG, Paul RJ. Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models. The Journal of Physiology. 535: 867-78. PMID 11559781 DOI: 10.1111/J.1469-7793.2001.00867.X  0.453
2001 Sato Y, Schmidt AG, Kiriazis H, Hoit BD, Kranias EG. Letter to the editor: Re-evaluation of heart failure in transgenic mice with impaired SR Ca2+ release. Journal of Molecular and Cellular Cardiology. 33: 1757-9. PMID 11549354 DOI: 10.1006/Jmcc.2001.1430  0.465
2001 Carr AN, Sutliff RL, Weber CS, Allen PB, Greengard P, de Lanerolle P, Kranias EG, Paul RJ. Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. The Journal of Physiology. 534: 357-66. PMID 11454956 DOI: 10.1111/J.1469-7793.2001.00357.X  0.62
2001 Dash R, Frank KF, Carr AN, Moravec CS, Kranias EG. Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium. Journal of Molecular and Cellular Cardiology. 33: 1345-53. PMID 11437540 DOI: 10.1006/Jmcc.2001.1394  0.791
2001 Aronow BJ, Toyokawa T, Canning A, Haghighi K, Delling U, Kranias E, Molkentin JD, Dorn GW. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy Physiological Genomics. 6: 19-28. PMID 11395543 DOI: 10.1152/Physiolgenomics.2001.6.1.19  0.329
2001 Slack JP, Grupp IL, Dash R, Holder D, Schmidt A, Gerst MJ, Tamura T, Tilgmann C, James PF, Johnson R, Gerdes AM, Kranias EG. The enhanced contractility of the phospholamban-deficient mouse heart persists with aging. Journal of Molecular and Cellular Cardiology. 33: 1031-40. PMID 11343424 DOI: 10.1006/Jmcc.2001.1370  0.701
2001 Haghighi K, Schmidt AG, Hoit BD, Brittsan AG, Yatani A, Lester JW, Zhai J, Kimura Y, Dorn GW, MacLennan DH, Kranias EG. Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure. The Journal of Biological Chemistry. 276: 24145-52. PMID 11328820 DOI: 10.1074/Jbc.M102403200  0.85
2001 Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of Clinical Investigation. 107: 967-74. PMID 11306600 DOI: 10.1172/Jci12083  0.487
2001 Dash R, Kadambi V, Schmidt AG, Tepe NM, Biniakiewicz D, Gerst MJ, Canning AM, Abraham WT, Hoit BD, Liggett SB, Lorenz JN, Dorn GW, Kranias EG. Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation. 103: 889-96. PMID 11171800 DOI: 10.1161/01.Cir.103.6.889  0.617
2001 Sato Y, Kiriazis H, Yatani A, Schmidt AG, Hahn H, Ferguson DG, Sako H, Mitarai S, Honda R, Mesnard-Rouiller L, Frank KF, Beyermann B, Wu G, Fujimori K, Dorn GW, ... Kranias EG, et al. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. The Journal of Biological Chemistry. 276: 9392-9. PMID 11115498 DOI: 10.1074/Jbc.M006889200  0.562
2001 Chu G, Lester JW, Young KB, Luo W, Zhai J, Kranias EG. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists. The Journal of Biological Chemistry. 275: 38938-43. PMID 10988285 DOI: 10.1074/Jbc.M004079200  0.476
2001 Young KB, Chu G, Gerst M, Song Q, Robbinst J, Grupp IL, Kranias EG. Overexpression of phospholamban in slow-twitch skeletal muscle alters sarcoplasmic reticulum CA2+ transport and muscle relaxation Journal of Molecular and Cellular Cardiology. 33: A135. DOI: 10.1016/S0022-2828(01)90536-X  0.715
2001 Sato Y, Smith AG, Kiriazis H, Holt BD, Kranias EG. Cardiac hypertrophy of aged transgenic FVB/N mice overexpressing calsequestrin Journal of Molecular and Cellular Cardiology. 33: A106. DOI: 10.1016/S0022-2828(01)90422-5  0.367
2000 Frank K, Kranias EG. Phospholamban and cardiac contractility. Annals of Medicine. 32: 572-8. PMID 11127935 DOI: 10.3109/07853890008998837  0.531
2000 Brittsan AG, Kranias EG. Phospholamban and cardiac contractile function. Journal of Molecular and Cellular Cardiology. 32: 2131-9. PMID 11112989 DOI: 10.1006/Jmcc.2000.1270  0.806
2000 Shannon TR, Chu G, Kranias EG, Bers DM. Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. The Journal of Biological Chemistry. 276: 7195-201. PMID 11087739 DOI: 10.1074/Jbc.M007085200  0.464
2000 Frank K, Tilgmann C, Shannon TR, Bers DM, Kranias EG. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry. 39: 14176-82. PMID 11087366 DOI: 10.1021/Bi001049K  0.534
2000 Schmidt AG, Kadambi VJ, Ball N, Sato Y, Walsh RA, Kranias EG, Hoit BD. Cardiac-specific overexpression of calsequestrin results in left ventricular hypertrophy, depressed force-frequency relation and pulsus alternans in vivo. Journal of Molecular and Cellular Cardiology. 32: 1735-44. PMID 10966834 DOI: 10.1006/Jmcc.2000.1209  0.473
2000 Kiriazis H, Kranias EG. Genetically engineered models with alterations in cardiac membrane calcium-handling proteins. Annual Review of Physiology. 62: 321-51. PMID 10845094 DOI: 10.1146/Annurev.Physiol.62.1.321  0.514
2000 Zvaritch E, Backx PH, Jirik F, Kimura Y, de Leon S, Schmidt AG, Hoit BD, Lester JW, Kranias EG, MacLennan DH. The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility. The Journal of Biological Chemistry. 275: 14985-91. PMID 10809743 DOI: 10.1074/Jbc.275.20.14985  0.51
2000 Brittsan AG, Carr AN, Schmidt AG, Kranias EG. Maximal inhibition of SERCA2 Ca(2+) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholamban. The Journal of Biological Chemistry. 275: 12129-35. PMID 10766848 DOI: 10.1074/Jbc.275.16.12129  0.846
2000 Schwinger RH, Brixius K, Savvidou-Zaroti P, Bölck B, Zobel C, Frank K, Kranias EG, Hoischen S, Erdmann E. The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in (Ca2+)-sensitivity or myosin ATPase-activity of the contractile proteins. Basic Research in Cardiology. 95: 12-8. PMID 10752541 DOI: 10.1007/S003950050003  0.485
2000 Zhai J, Schmidt AG, Hoit BD, Kimura Y, MacLennan DH, Kranias EG. Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo. The Journal of Biological Chemistry. 275: 10538-44. PMID 10744747 DOI: 10.1074/Jbc.275.14.10538  0.566
2000 Hoit BD, Kadambi VJ, Tramuta DA, Ball N, Kranias EG, Walsh RA. Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution. American Journal of Physiology. Heart and Circulatory Physiology. 278: H958-63. PMID 10710365 DOI: 10.1152/Ajpheart.2000.278.3.H958  0.422
2000 Li L, Desantiago J, Chu G, Kranias EG, Bers DM. Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation. American Journal of Physiology. Heart and Circulatory Physiology. 278: H769-79. PMID 10710345 DOI: 10.1152/Ajpheart.2000.278.3.H769  0.488
2000 Bluhm WF, Kranias EG, Dillmann WH, Meyer M. Phospholamban: a major determinant of the cardiac force-frequency relationship. American Journal of Physiology. Heart and Circulatory Physiology. 278: H249-55. PMID 10644605 DOI: 10.1152/Ajpheart.2000.278.1.H249  0.372
2000 Chu G, Ferguson DG, Edes I, Kiss E, Sato Y, Kranias EG. Phospholamban ablation and compensatory responses in the mammalian heart. Annals of the New York Academy of Sciences. 853: 49-62. PMID 10603936 DOI: 10.1111/J.1749-6632.1998.Tb08256.X  0.591
1999 Lalli MJ, Shimizu S, Sutliff RL, Kranias EG, Paul RJ. [Ca]homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. American Journal of Physiology. Heart and Circulatory Physiology. 277: H963-H970. PMID 29592078 DOI: 10.1152/ajpheart.1999.277.3.H963  0.428
1999 Tepe NM, Lorenz JN, Yatani A, Dash R, Kranias EG, Dorn GW, Liggett SB. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry. 38: 16706-13. PMID 10600134 DOI: 10.1021/Bi991619K  0.693
1999 Hoit BD, Tramuta DA, Kadambi VJ, Dash R, Ball N, Kranias EG, Walsh RA. Influence of transgenic overexpression of phospholamban on postextrasystolic potentiation. Journal of Molecular and Cellular Cardiology. 31: 2007-15. PMID 10591027 DOI: 10.1006/Jmcc.1999.1031  0.628
1999 Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Kranias EG, Giles WR, Chien KR. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99: 313-22. PMID 10555147 DOI: 10.1016/S0092-8674(00)81662-1  0.523
1999 Lalli MJ, Shimizu S, Sutliff RL, Kranias EG, Paul RJ. [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. The American Journal of Physiology. 277: H963-70. PMID 10484417 DOI: 10.1152/Ajpheart.1999.277.3.H963  0.518
1999 Brittsan AG, Kiss E, Edes I, Grupp IL, Grupp G, Kranias EG. The effect of isoproterenol on phospholamban-deficient mouse hearts with altered thyroid conditions. Journal of Molecular and Cellular Cardiology. 31: 1725-37. PMID 10471356 DOI: 10.1006/Jmcc.1999.1010  0.82
1999 Yatani A, Frank K, Sako H, Kranias EG, Dorn GW. Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes. Journal of Molecular and Cellular Cardiology. 31: 1327-36. PMID 10403750 DOI: 10.1006/Jmcc.1999.0966  0.506
1999 Kadambi VJ, Ball N, Kranias EG, Walsh RA, Hoit BD. Modulation of force-frequency relation by phospholamban in genetically engineered mice. The American Journal of Physiology. 276: H2245-50. PMID 10362708 DOI: 10.1152/Ajpheart.1999.276.6.H2245  0.429
1999 Desai KH, Schauble E, Luo W, Kranias E, Bernstein D. Phospholamban deficiency does not compromise exercise capacity. The American Journal of Physiology. 276: H1172-7. PMID 10199840 DOI: 10.1152/Ajpheart.1999.276.4.H1172  0.337
1999 Pan BS, Hannon JD, Wiedmann R, Potter JD, Kranias EG, Shen YT, Johnson RG, Housmans PR. Effects of isoproterenol on twitch contraction of wild type and phospholamban-deficient murine ventricular myocardium. Journal of Molecular and Cellular Cardiology. 31: 159-66. PMID 10072724 DOI: 10.1006/Jmcc.1998.0854  0.325
1999 Sutliff RL, Hoying JB, Kadambi VJ, Kranias EG, Paul RJ. Phospholamban is present in endothelial cells and modulates endothelium- dependent relaxation evidence from phospholamban gene-ablated mice Circulation Research. 84: 360-364. PMID 10024311 DOI: 10.1161/01.Res.84.3.360  0.377
1999 Banerjee A, Joshi P, Harrer JM, Kranias EG, Hoit BD. Delayed Restitution of Contractility Reflects Impaired Calcium Handling in Pacing Induced Heart Failure in Immature Goats Pediatric Research. 45: 19A-19A. DOI: 10.1203/00006450-199904020-00119  0.387
1999 Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Ross J, Giles WR, Kranias EG, Chien KR. Genetic complementation identifies phospholamban- sarcoplasmic reticulum Ca ATPase interaction as the primary defect that drives the onset of heart failure in dilated cardiomyopathy Journal of Cardiac Failure. 5: 21. DOI: 10.1016/S1071-9164(99)91421-5  0.47
1999 Haghighi K, Hoi BD, Schmidt A, Kimura Y, Brittsan AG, MacLennan DH, Kranias EG. Cardiac overexpression of a mutant form of phospholamban is associated with depressed contractility and hypertrophy Journal of Cardiac Failure. 5: 11. DOI: 10.1016/S1071-9164(99)91386-6  0.796
1999 Frank K, Dash R, Moravec C, Kranias E. Human failing myocardium exhibits decreased Ser-16 and Thr-17 phospholamban phosphorylation and decreased apparent affinity of the sarcoplasmic Ca2+-ATPase for Ca2+ Journal of Cardiac Failure. 5: 8. DOI: 10.1016/S1071-9164(99)91372-6  0.696
1999 Zhai J, MacLennan DH, Kranias EG. Overexpression of a phospholamban Asp27 to Ala mutant is associated with significant inhibition of cardiac function Journal of Cardiac Failure. 5: 8. DOI: 10.1016/S1071-9164(99)91371-4  0.422
1999 Dash R, Slack J, Grupp I, Holder D, Tilgmann C, Tamura T, Johnson R, Gerdes A, Kranias E. Aging is associated with progressive increases in Na+/Ca2+ exchanger and Na+/K+-ATPase protein levels in the marine heart Journal of Cardiac Failure. 5: 7. DOI: 10.1016/S1071-9164(99)91370-2  0.671
1999 Carr AN, Sato Y, Neirouz Y, Schmidt A, Hoit BD, Grupp IL, Allen PB, Greengard P, Kranias EG. Protein phosphatase inhibitor-1 ablation results in depressed cardiac contractility in response to β-adrenergic stimulation and decreased phosphorylation of phospholamban Journal of Cardiac Failure. 5: 7. DOI: 10.1016/S1071-9164(99)91369-6  0.59
1999 Carr AN, Suzuki Y, Sato Y, Schmidt A, Kadambi VJ, Hoit BD, Grupp IL, Jing S, Field LJ, DePaoli-Roach A, Kranias EG. Cardiac-specific overexpression of the sarcoplasmic reticulum and glycogen targeting subunit of the type I phosphatase does not result in altered cardiac contractility Journal of Cardiac Failure. 5: 7. DOI: 10.1016/S1071-9164(99)91368-4  0.624
1999 Kiriazis H, Schmidt A, Sato Y, Kranias EG, Hoit BD. Effects of aging on mouse hearts with cardiac-specific overexpression of murine cardiac calsequestrin Journal of Cardiac Failure. 5: 6. DOI: 10.1016/S1071-9164(99)91363-5  0.452
1999 Schmidt A, Zhai J, Zvarich E, MacLennan DH, Kranias EG, Hoit BD. In vivo echocardiographic assessment of contractile dysfunction in transgenic mice overexpressing two different mutant forms of phospholamban Journal of Cardiac Failure. 5: 4. DOI: 10.1016/S1071-9164(99)91357-X  0.318
1998 Li L, Chu G, Kranias EG, Bers DM. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1335-H1347. PMID 29586013 DOI: 10.1152/Ajpheart.1998.274.4.H1335  0.488
1998 Kristof E, Szigeti G, Papp Z, Bodi A, Facsko A, Kovacs L, Papp JG, Kranias EG, Edese I. Cardiac responses to calcium sensitizers and isoproterenol in intact guinea pig hearts. Effects on cyclic AMP levels, protein phosphorylation, myoplasmic calcium concentration, and left ventricular function. Annals of the New York Academy of Sciences. 853: 316-319. PMID 10603968 DOI: 10.1111/J.1749-6632.1998.Tb08288.X  0.442
1998 Wiedmann RT, Pan BS, Kranias EG, Motzel S, Johnson RG. Phospholamban gene dosage effects in chemically permeabilized mouse cardiac muscle. Annals of the New York Academy of Sciences. 853: 296-9. PMID 10603963 DOI: 10.1111/J.1749-6632.1998.Tb08283.X  0.36
1998 Kadambi VJ, Kranias EG. Genetically engineered mice: model systems for left ventricular failure. Journal of Cardiac Failure. 4: 349-61. PMID 9924857 DOI: 10.1016/S1071-9164(98)90241-X  0.447
1998 Chu G, Li L, Sato Y, Harrer JM, Kadambi VJ, Hoit BD, Bers DM, Kranias EG. Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo. The Journal of Biological Chemistry. 273: 33674-80. PMID 9837953 DOI: 10.1074/Jbc.273.50.33674  0.534
1998 Sato Y, Ferguson DG, Sako H, Dorn GW, Kadambi VJ, Yatani A, Hoit BD, Walsh RA, Kranias EG. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. The Journal of Biological Chemistry. 273: 28470-7. PMID 9774476 DOI: 10.1074/Jbc.273.43.28470  0.579
1998 Kiss E, Brittsan AG, Edes I, Grupp IL, Grupp G, Kranias EG. Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts. Circulation Research. 83: 608-13. PMID 9742056 DOI: 10.1161/01.Res.83.6.608  0.842
1998 Kadambi VJ, Koss KL, Grupp IL, Kranias EG. Phospholamban modulates murine atrial contractile parameters and responses to beta-adrenergic agonists. Journal of Molecular and Cellular Cardiology. 30: 1275-84. PMID 9710796 DOI: 10.1006/Jmcc.1998.0688  0.387
1998 Takeishi Y, Chu G, Kirkpatrick DM, Li Z, Wakasaki H, Kranias EG, King GL, Walsh RA. In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. The Journal of Clinical Investigation. 102: 72-8. PMID 9649559 DOI: 10.1172/Jci2709  0.596
1998 Masaki H, Sako H, Kadambi VJ, Sato Y, Kranias EG, Yatani A. Overexpression of phospholamban alters inactivation kinetics of L-type Ca2+ channel currents in mouse atrial myocytes. Journal of Molecular and Cellular Cardiology. 30: 317-25. PMID 9515008 DOI: 10.1006/Jmcc.1997.0594  0.473
1998 Luo W, Chu G, Sato Y, Zhou Z, Kadambi VJ, Kranias EG. Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. The Journal of Biological Chemistry. 273: 4734-9. PMID 9468536 DOI: 10.1074/Jbc.273.8.4734  0.484
1998 Banerjee A, Shah DP, Kadambi VJ, Manning PB, Kranias EG. Altered Atrial Function and Associated Changes in Proteins Responsible for Myocardial Contraction and Relaxation in Right Atria of Children With Tetralogy of Fallot • 84 Pediatric Research. 43: 17-17. DOI: 10.1203/00006450-199804001-00105  0.322
1998 Banerjee A, Shah S, Joshi P, Gabel M, Hoit BD, Kranias EG. Physiologic and Molecular Changes Reflecting Impaired Calcium Cycling in Pacing Induced Heart Failure in Immature Goats ♦ 83 Pediatric Research. 43: 17-17. DOI: 10.1203/00006450-199804001-00104  0.496
1998 Yatani A, Sato Y, Sako H, Kranias EG. Subcellular mechanisms in transgenic cardiac myocytes with altered excitation-contraction (E-C) coupling Journal of Cardiac Failure. 4: 33. DOI: 10.1016/S1071-9164(98)90120-8  0.36
1998 Takeishi Y, Chu G, Kirkpatirck DM, Kranias EG, King GL, Walsh RA. In vivo phosphorylation of cardiac troponin I by PKCβ2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts Journal of Cardiac Failure. 4: 21. DOI: 10.1016/S1071-9164(98)90075-6  0.489
1998 Dash R, Kadambi VJ, Harrer JM, Hoit BD, Kranias EG. Transgenic approaches to uncover the functional stoichiometry of phospholamban to sarcoplasmic reticulum Ca2+-ATPase in vivo Journal of Cardiac Failure. 4: 20. DOI: 10.1016/S1071-9164(98)90074-4  0.679
1998 Brittsan AG, Kadambi VJ, Hoit BD, Kranias EG. Cardiac overexpression of a non-phosphorylatable form of phospholamban results in depressed contractile function and hypertrophy Journal of Cardiac Failure. 4: 20. DOI: 10.1016/S1071-9164(98)90072-0  0.796
1998 Kiriazis H, Kadambi VJ, Suresh DP, Johnson RG, Kranias EG, Hoit BD. Transverse aortic banding leads to depressed in vivo left ventricular function in phospholamban ablated mice Journal of Cardiac Failure. 4: 6. DOI: 10.1016/S1071-9164(98)90020-3  0.323
1998 Sato Y, Yamamoto S, Yatani A, Kranias EG. Rescue of the depressed contractile parameters in calsequestrin overexpressing hearts by phospholamban ablation Journal of Cardiac Failure. 4: 6. DOI: 10.1016/S1071-9164(98)90019-7  0.531
1998 Banerjee A, Joshi P, Gabel M, Harrer JM, Kranias EG, Hoit BD. Pacing induced heart failure in immature goats: Physiologic and molecular changes reflect impaired calcium cycling by sarcoplasmic reticulum Journal of Cardiac Failure. 4: 5. DOI: 10.1016/S1071-9164(98)90017-3  0.394
1998 Chu G, Lester JW, Luo W, MesnardRouiller L, Kranias EG. Functional significance of dual site phospholamban phosphorylation in transgenic mice Journal of Cardiac Failure. 4: 4. DOI: 10.1016/S1071-9164(98)90014-8  0.305
1998 KRANIAS E. Cardiac function and dysfunction: Molecular and cellular mechanisms American Journal of Hypertension. 11: 235A. DOI: 10.1016/S0895-7061(97)91581-8  0.392
1997 Lorenz JN, Kranias EG. Regulatory effects of phospholamban on cardiac function in intact mice. American Journal of Physiology. Heart and Circulatory Physiology. 273: H2826-H2831. PMID 29586138 DOI: 10.1152/Ajpheart.1997.273.6.H2826  0.417
1997 Liu Y, Kranias EG, Schneider MF. Regulation of Ca2+ handling by phosphorylation status in mouse fast- and slow-twitch skeletal muscle fibers. The American Journal of Physiology. 273: C1915-24. PMID 9435497 DOI: 10.1152/Ajpcell.1997.273.6.C1915  0.436
1997 Haghighi K, Kadambi VJ, Koss KL, Luo W, Harrer JM, Ponniah S, Zhou Z, Kranias EG. In vitro and in vivo promoter analyses of the mouse phospholamban gene Gene. 203: 199-207. PMID 9426251 DOI: 10.1016/S0378-1119(97)00514-3  0.337
1997 Sako H, Green SA, Kranias EG, Yatani A. Modulation of cardiac Ca2+ channels by isoproterenol studied in transgenic mice with altered SR Ca2+ content American Journal of Physiology - Cell Physiology. 273. PMID 9374653 DOI: 10.1152/Ajpcell.1997.273.5.C1666  0.483
1997 Kadambi VJ, Kranias EG. Phospholamban: a protein coming of age. Biochemical and Biophysical Research Communications. 239: 1-5. PMID 9345259 DOI: 10.1006/Bbrc.1997.7340  0.513
1997 Chu G, Dorn GW, Luo W, Harrer JM, Kadambi VJ, Walsh RA, Kranias EG. Monomeric phospholamban overexpression in transgenic mouse hearts. Circulation Research. 81: 485-92. PMID 9314829 DOI: 10.1161/01.Res.81.4.485  0.564
1997 Santana LF, Kranias EG, Lederer WJ. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. The Journal of Physiology. 503: 21-9. PMID 9288671 DOI: 10.1111/J.1469-7793.1997.021Bi.X  0.459
1997 Slack JP, Grupp IL, Luo W, Kranias EG. Phospholamban ablation enhances relaxation in the murine soleus. The American Journal of Physiology. 273: C1-6. PMID 9252436 DOI: 10.1152/Ajpcell.1997.273.1.C1  0.356
1997 Slack JP, Grupp IL, Ferguson DG, Rosenthal N, Kranias EG. Ectopic expression of phospholamban in fast-twitch skeletal muscle alters sarcoplasmic reticulum Ca2+ transport and muscle relaxation. The Journal of Biological Chemistry. 272: 18862-8. PMID 9228063 DOI: 10.1074/Jbc.272.30.18862  0.371
1997 Koss KL, Grupp IL, Kranias EG. The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility. Basic Research in Cardiology. 17-24. PMID 9202840 DOI: 10.1007/Bf00794064  0.515
1997 Kiss E, Edes I, Sato Y, Luo W, Liggett SB, Kranias EG. beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. The American Journal of Physiology. 272: H785-90. PMID 9124439 DOI: 10.1152/Ajpheart.1997.272.2.H785  0.47
1997 Masaki H, Sato Y, Luo W, Kranias EG, Yatani A. Phospholamban deficiency alters inactivation kinetics of L-type Ca2+ channels in mouse ventricular myocytes. The American Journal of Physiology. 272: H606-12. PMID 9124415 DOI: 10.1152/Ajpheart.1997.272.2.H606  0.479
1997 Lalli J, Harrer JM, Luo W, Kranias EG, Paul RJ. Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle. Circulation Research. 80: 506-13. PMID 9118481 DOI: 10.1161/01.Res.80.4.506  0.469
1997 Harrer JM, Haghighi K, Kim HW, Ferguson DG, Kranias EG. Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart. The American Journal of Physiology. 272: H57-66. PMID 9038922 DOI: 10.1152/Ajpheart.1997.272.1.H57  0.503
1997 Koss KL, Kranias EG. Phospholamban: a prominent regulator of myocardial contractility. Circulation Research. 79: 1059-63. PMID 8943944 DOI: 10.1161/01.Res.79.6.1059  0.557
1996 Chu G, Luo W, Slack JP, Tilgmann C, Sweet WE, Spindler M, Saupe KW, Boivin GP, Moravec CS, Matlib MA, Grupp IL, Ingwall JS, Kranias EG. Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse hearts. Circulation Research. 79: 1064-76. PMID 8943945 DOI: 10.1161/01.Res.79.6.1064  0.573
1996 Hampton TG, Kranias EG, Morgan JP. Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart. Biochemical and Biophysical Research Communications. 226: 836-41. PMID 8831698 DOI: 10.1006/Bbrc.1996.1437  0.466
1996 Wolska BM, Stojanovic MO, Luo W, Kranias EG, Solaro RJ. Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca2+ American Journal of Physiology - Cell Physiology. 271. PMID 8760070 DOI: 10.1152/Ajpcell.1996.271.1.C391  0.46
1996 Luo W, Wolska BM, Grupp IL, Harrer JM, Haghighi K, Ferguson DG, Slack JP, Grupp G, Doetschman T, Solaro RJ, Kranias EG. Phospholamban gene dosage effects in the mammalian heart. Circulation Research. 78: 839-47. PMID 8620604 DOI: 10.1161/01.Res.78.5.839  0.575
1996 Kadambi VJ, Ponniah S, Harrer JM, Hoit BD, Dorn GW, Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. The Journal of Clinical Investigation. 97: 533-9. PMID 8567978 DOI: 10.1172/Jci118446  0.578
1996 Szymanska G, Grupp IL, Slack JP, Harrer JM, Kranias EG. Alterations in sarcoplasmic reticulum calcium uptake, relaxation parameters and their responses to beta-adrenergic agonists in the developing rabbit heart. Journal of Molecular and Cellular Cardiology. 27: 1819-29. PMID 8523443 DOI: 10.1016/0022-2828(95)90005-5  0.537
1996 Holt BD, Khan ZU, Ball N, Kadambi VJ, Kranias EG, Walsh RA. Echocardiographic assessment of left ventricular systolic function in transgenic mice with cardiac specific over-expression of phospholamban Journal of the American College of Cardiology. 27: 50. DOI: 10.1016/S0735-1097(96)80391-3  0.408
1995 Harrer JM, Kranias EG. Characterization of the molecular form of cardiac phospholamban. Molecular and Cellular Biochemistry. 140: 185-93. PMID 7898490 DOI: 10.1007/Bf00926757  0.389
1995 Edes I, Kiss E, Kitada Y, Powers FM, Papp JG, Kranias EG, Solaro RJ. Effects of Levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circulation Research. 77: 107-13. PMID 7788868 DOI: 10.1161/01.Res.77.1.107  0.526
1995 Harrer JM, Ponniah S, Ferguson DG, Kranias EG. Expression of phospholamban in C2C12 cells and regulation of endogenous SERCA1 activity. Molecular and Cellular Biochemistry. 146: 13-21. PMID 7651372 DOI: 10.1007/Bf00926876  0.466
1995 Hoit BD, Khoury SF, Kranias EG, Ball N, Walsh RA. In vivo echocardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circulation Research. 77: 632-7. PMID 7641333 DOI: 10.1161/01.Res.77.3.632  0.355
1995 Kiss E, Ball NA, Kranias EG, Walsh RA. Differential changes in cardiac phospholamban and sarcoplasmic reticular Ca2+-ATPase protein levels: Effects on Ca2+ transport and mechanics in compensated pressure-overload hypertrophy and congestive heart failure Circulation Research. 77: 759-764. PMID 7554123 DOI: 10.1161/01.Res.77.4.759  0.522
1995 Koss KL, Ponniah S, Jones WK, Grupp IL, Kranias EG. Differential phospholamban gene expression in murine cardiac compartments. Molecular and physiological analyses. Circulation Research. 77: 342-53. PMID 7542181 DOI: 10.1161/01.Res.77.2.342  0.442
1994 Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circulation Research. 75: 401-9. PMID 8062415 DOI: 10.1161/01.Res.75.3.401  0.529
1994 Kiss E, Jakab G, Kranias EG, Edes I. Thyroid hormone-induced alterations in phospholamban protein expression. Regulatory effects on sarcoplasmic reticulum Ca2+ transport and myocardial relaxation. Circulation Research. 75: 245-51. PMID 8033338 DOI: 10.1161/01.Res.75.2.245  0.549
1993 Talosi L, Edes I, Kranias EG. Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts. The American Journal of Physiology. 264: H791-7. PMID 8384422 DOI: 10.1152/Ajpheart.1993.264.3.H791  0.488
1993 Hardin CD, Zhang C, Kranias EG, Steenaart NAE, Raeymaekers L, Paul RJ. Regulation of glycolytically fueled Ca2+ uptake in smooth muscle plasmalemmal vesicles by phosphorylation American Journal of Physiology - Heart and Circulatory Physiology. 265. PMID 8238421 DOI: 10.1152/Ajpheart.1993.265.4.H1326  0.469
1993 Szymańska G, Kim HW, Cuppoletti J, Kranias EG. Regulation of the skeletal sarcoplasmic reticulum Ca(2+)-ATPase by phospholamban and negatively charged phospholipids in reconstituted phospholipid vesicles. Molecular and Cellular Biochemistry. 114: 65-71. PMID 1461259 DOI: 10.1007/Bf00240299  0.488
1992 Szymańska G, Kim HW, Cuppoletti J, Kranias EG. Regulation of the skeletal sarcoplasmic reticulum Ca2+ pump by phospholamban in reconstituted phospholipid vesicles. Membrane Biochemistry. 9: 191-202. PMID 2152030 DOI: 10.3109/09687689009025840  0.415
1992 Edes I, Talosi L, Kranias EG. The effect of alpha-adrenergic agents and protein kinase C activators on protein phosphorylation in isolated guinea pig hearts. European Heart Journal. 143-4. PMID 1804635 DOI: 10.1093/Eurheartj/12.Suppl_F.143  0.419
1992 Zhang C, Paul RJ, Kranias EG. Calmodulin stimulation of smooth muscle plasmalemmal vesicle Ca2+ uptake: direct or indirect effect? The American Journal of Physiology. 263: H366-71. PMID 1510133 DOI: 10.1152/Ajpheart.1992.263.2.H366  0.462
1992 Ganim JR, Luo W, Ponniah S, Grupp I, Kim HW, Ferguson DG, Kadambi V, Neumann JC, Doetschman T, Kranias EG. Mouse phospholamban gene expression during development in vivo and in vitro. Circulation Research. 71: 1021-30. PMID 1394867 DOI: 10.1161/01.Res.71.5.1021  0.517
1992 Talosi L, Kranias EG. Effect of alpha-adrenergic stimulation on activation of protein kinase C and phosphorylation of proteins in intact rabbit hearts. Circulation Research. 70: 670-8. PMID 1312911 DOI: 10.1161/01.Res.70.4.670  0.39
1992 Steenaart NA, Ganim JR, Di Salvo J, Kranias EG. The phospholamban phosphatase associated with cardiac sarcoplasmic reticulum is a type 1 enzyme. Archives of Biochemistry and Biophysics. 293: 17-24. PMID 1309982 DOI: 10.1016/0003-9861(92)90359-5  0.48
1992 KRANIAS E. The role of phospholamban in reconstituted systems and in the intact heart Journal of Molecular and Cellular Cardiology. 24: S32. DOI: 10.1016/0022-2828(92)90938-V  0.367
1991 Davis BA, Edes I, Gupta RC, Young EF, Kim HW, Steenaart NA, Szymanska G, Kranias EG. The role of phospholamban in the regulation of calcium transport by cardiac sarcoplasmic reticulum. Molecular and Cellular Biochemistry. 99: 83-8. PMID 1962847 DOI: 10.1007/Bf00230337  0.487
1991 Edes I, Talosi L, Kranias EG. Effect of alpha adrenergic agents and phorbol esters on phosphorylation of sarcolemmal proteins in beating guinea pig hearts. Cardiovascular Research. 25: 510-5. PMID 1889064 DOI: 10.1093/Cvr/25.6.510  0.391
1991 Szymańska G, Kim HW, Kranias EG. Reconstitution of the skeletal sarcoplasmic reticulum Ca2(+)-pump: influence of negatively charged phospholipids. Biochimica Et Biophysica Acta. 1091: 127-34. PMID 1825285 DOI: 10.1016/0167-4889(91)90051-X  0.433
1991 Gupta RC, Young EF, Ferguson DG, Kranias EG. Regulation of rat cardiac nuclei-associated Mg(2+)-NTPase by phosphorylation. Molecular and Cellular Biochemistry. 102: 165-72. PMID 1652681 DOI: 10.1007/Bf00234574  0.483
1990 Edes I, Kranias EG. Phospholamban and troponin I are substrates for protein kinase C in vitro but not in intact beating guinea pig hearts. Circulation Research. 67: 394-400. PMID 2165444 DOI: 10.1161/01.Res.67.2.394  0.431
1990 Edes I, Kranias EG. Characterization of cytoplasmic and membrane-associated phosphatidylinositol 4,5-biphosphate phospholipase C activities in guinea pig ventricles. Basic Research in Cardiology. 85: 78-87. PMID 2158298 DOI: 10.1007/Bf01907016  0.337
1989 Edes I, Kranias EG. Regulation of cardiac sarcoplasmic reticulum function by phospholamban. Membrane Biochemistry. 7: 175-92. PMID 2855362 DOI: 10.3109/09687688709039993  0.396
1989 Gupta RC, Kranias EG. Purification and characterization of a calcium-calmodulin-dependent phospholamban kinase from canine myocardium. Biochemistry. 28: 5909-16. PMID 2775741 DOI: 10.1021/Bi00440A030  0.448
1989 Edes I, Solaro RJ, Kranias EG. Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol Circulation Research. 65: 989-996. PMID 2551534 DOI: 10.1161/01.Res.65.4.989  0.42
1989 Rapundalo ST, Solaro RJ, Kranias EG. Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: Comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins Circulation Research. 64: 104-111. PMID 2535795 DOI: 10.1161/01.Res.64.1.104  0.394
1988 Ferguson DG, Young EF, Raeymaekers L, Kranias EG. Localization of phospholamban in smooth muscle using immunogold electron microscopy. The Journal of Cell Biology. 107: 555-62. PMID 3417762 DOI: 10.1083/Jcb.107.2.555  0.346
1988 Jakab G, Rapundalo ST, Solaro RJ, Kranias EG. Phosphorylation of phospholipids in isolated guinea pig hearts stimulated with isoprenaline Biochemical Journal. 251: 189-194. PMID 3390153 DOI: 10.1042/Bj2510189  0.427
1988 Gupta RC, Davis BA, Kranias EG. Mechanism of the stimulation of cardiac sarcoplasmic reticulum calcium pump by calmodulin. Membrane Biochemistry. 7: 73-86. PMID 2970004 DOI: 10.3109/09687688709039985  0.425
1988 Garvey JL, Kranias EG, Solaro RJ. Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts Biochemical Journal. 249: 709-714. PMID 2895634 DOI: 10.1042/Bj2490709  0.485
1988 Kranias EG, Gupta RC, Jakab G, Kim HW, Steenaart NA, Rapundalo ST. The role of protein kinases and protein phosphatases in the regulation of cardiac sarcoplasmic reticulum function. Molecular and Cellular Biochemistry. 82: 37-44. PMID 2847012 DOI: 10.1007/Bf00242513  0.449
1988 Jakab G, Kranias EG. Phosphorylation and dephosphorylation of purified phospholamban and associated phosphatidylinositides. Biochemistry. 27: 3799-806. PMID 2841974 DOI: 10.1021/Bi00410A042  0.375
1988 Edes I, Solaro R, Kranias E. Beta adrenergic receptor mediated inhibition of phosphoinositide turnover in isolated perfused guinea pig hearts Journal of Molecular and Cellular Cardiology. 20: 23. DOI: 10.1016/S0022-2828(98)90068-2  0.34
1987 Kim HW, Kim DH, Ikemoto N, Kranias EG. Lack of effects of calcium X calmodulin-dependent phosphorylation on Ca2+ release from cardiac sarcoplasmic reticulum. Biochimica Et Biophysica Acta. 903: 333-40. PMID 2443173 DOI: 10.1016/0005-2736(87)90223-9  0.486
1986 Lee SW, Wallick ET, Schwartz A, Kranias EG. Influence of protein kinase phosphorylation on isolated sarcolemmal membranes. Journal of Molecular and Cellular Cardiology. 17: 1085-93. PMID 3001320 DOI: 10.1016/S0022-2828(85)80124-3  0.383
1985 Kranias EG, Garvey JL, Srivastava RD, Solaro RJ. Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline Biochemical Journal. 226: 113-121. PMID 3156585 DOI: 10.1042/Bj2260113  0.51
1985 Kranias EG. Regulation of Ca2+ transport by cyclic 3',5'-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochimica Et Biophysica Acta. 844: 193-9. PMID 2982423 DOI: 10.1016/0167-4889(85)90090-4  0.505
1984 Kranias EG, Nakamura J, Schwartz A. Phospholamban, the regulator of the cardiac sarcoplasmic reticulum calcium pump, does not copurify with the Ca2+-ATPase enzyme. Biochimica Et Biophysica Acta. 749: 62-8. PMID 6315068 DOI: 10.1016/0167-4838(83)90151-6  0.545
1984 Imai K, Wang T, Millard RW, Ashraf M, Kranias EG, Asano G, Grassi de Gende AO, Nagao T, Solaro RJ, Schwartz A. Ischaemia-induced changes in canine cardiac sarcoplasmic reticulum. Cardiovascular Research. 17: 696-709. PMID 6228297 DOI: 10.1093/Cvr/17.11.696  0.532
1983 Kranias EG, Samaha FJ, Schwartz A. Mechanism of the stimulation of Ca2+-dependent ATPase of skeletal muscle sarcoplasmic reticulum by protein kinase. Biochimica Et Biophysica Acta. 731: 79-87. PMID 6303413 DOI: 10.1016/0005-2736(83)90400-5  0.474
1983 Kranias EG, Schwartz A, Jungmann RA. Characterization of cyclic 3':5'-amp-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium. Biochimica Et Biophysica Acta. 709: 28-37. PMID 6295489 DOI: 10.1016/0167-4838(82)90417-4  0.7
1983 Collins JH, Zot AS, Kranias EG. Isolation of two proteolipids from rabbit skeletal muscle sarcoplasmic reticulum. Preparative Biochemistry. 12: 255-64. PMID 6216473 DOI: 10.1080/00327488208065566  0.306
1982 Bilezikjian LM, Kranias EG, Potter JD, Schwartz A. Studies on phosphorylation of canine cardiac sarcoplasmic reticulum by calmodulin-dependent protein kinase. Circulation Research. 49: 1356-62. PMID 6273007 DOI: 10.1161/01.Res.49.6.1356  0.441
1982 Kranias EG, Solaro RJ. Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart Nature. 298: 182-184. PMID 6211626 DOI: 10.1038/298182A0  0.557
1982 Mandel F, Kranias EG, Grassi de Gende A, Sumida M, Schwartz A. The effect of pH on the transient-state kinetics of Ca2+-Mg2+-ATPase of cardiac sarcoplasmic reticulum. A comparison with skeletal sarcoplasmic reticulum. Circulation Research. 50: 310-7. PMID 6120049 DOI: 10.1161/01.Res.50.2.310  0.432
1981 Collins JH, Kranias EG, Reeves AS, Bilezikjian LM, Schwartz A. Isolation of phospholamban and a second proteolipid component from canine cardiac sarcoplasmic reticulum. Biochemical and Biophysical Research Communications. 99: 796-803. PMID 6454414 DOI: 10.1016/0006-291X(81)91235-3  0.428
1981 Kranias EG, Bilezikjian LM, Potter JD, Piascik MT, Schwartz A. The role of calmodulin in regulation of cardiac sarcoplasmic reticulum phosphorylation. Annals of the New York Academy of Sciences. 356: 279-91. PMID 6263150 DOI: 10.1111/J.1749-6632.1980.Tb29618.X  0.463
1981 Kranias EG, Mandel F, Wang T, Schwartz A. Mechanism of the stimulation of calcium ion dependent adenosine triphosphatase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase. Biochemistry. 19: 5434-9. PMID 6255993 DOI: 10.1021/Bi00564A044  0.508
1980 Kranias EG, Mandel F, Schwartz A. Involvement of cAMP-dependent protein kinase and pH on the regulation of cardiac sarcoplasmic reticulum. Biochemical and Biophysical Research Communications. 92: 1370-6. PMID 6245652 DOI: 10.1016/0006-291X(80)90437-4  0.48
1978 Kranias G, Kranias E, Dobbie GJ, Jungmann RA, Edwards BK, Eppenberger U. Human platelet protein kinases in diabetic retinopathy. Febs Letters. 92: 357-60. PMID 212306 DOI: 10.1016/0014-5793(78)80786-8  0.594
1978 Kranias EG, Jungmann RA. Phosphorylation of calf thymus RNA polymerase II by nuclear cyclic 3',5'-AMP-independent protein kinase. Biochimica Et Biophysica Acta. 517: 439-46. PMID 203318 DOI: 10.1016/0005-2787(78)90210-1  0.6
1978 Kranias EG, Jungmann RA. Purification and properties of a cyclic AMP-independent protein kinase from calf thymus nuclei. Biochimica Et Biophysica Acta. 517: 447-56. PMID 23835 DOI: 10.1016/0005-2787(78)90211-3  0.638
1977 Jungmann RA, Kranias EG. Nuclear phosphoprotein kinases and the regulation of gene transcription International Journal of Biochemistry. 8: 819-830. DOI: 10.1016/0020-711X(77)90049-0  0.606
1975 Kranias EG, Dumas LB. Synthesis of complex forms of bacteriophage phiX174 double-stranded DNA in a temperature-sensitive dnaC mutant of Escherichia coli C. Journal of Virology. 16: 412-9. PMID 1097736 DOI: 10.1128/Jvi.16.2.412-419.1975  0.67
1974 Kranias EG, Dumas LB. Replication of bacteriophage phiX174 DNA in a temperature-sensitive dnaC mutant of escherichia coli C. Journal of Virology. 13: 146-54. PMID 4590017 DOI: 10.1128/jvi.13.1.146-154.1974  0.648
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