Roger J. Davis - Publications

Affiliations: 
University of Massachusetts Medical Center, Worcester, MA, United States 
Area:
JNK Stress Signaling Pathway
Website:
https://profiles.umassmed.edu/display/132098

352 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ. Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210434119. PMID 36282921 DOI: 10.1073/pnas.2210434119  0.306
2022 Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease. Journal of Cellular Signaling. 3: 62-78. PMID 35253003 DOI: 10.33696/Signaling.3.068  0.306
2021 Caliz AD, Yoo HJ, Vertii A, Dolan AC, Tournier C, Davis RJ, Keaney JF, Kant S. Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice. International Journal of Molecular Sciences. 22. PMID 34502275 DOI: 10.3390/ijms22179364  0.389
2021 Calamaras TD, Pande S, Baumgartner RA, Kim SK, McCarthy JC, Martin GL, Tam K, McLaughlin AL, Wang GR, Aronovitz MJ, Lin W, Aguirre JI, Baca P, Liu P, Richards DA, ... Davis RJ, et al. Mixed Lineage Kinase 3 mediates PKG1α impact on cardiac function and controls blood pressure through separate mechanisms. Jci Insight. PMID 34324442 DOI: 10.1172/jci.insight.149075  0.322
2020 Manieri E, Folgueira C, Rodríguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Rosell A, Sanchez-Cabo F, Gómez MJ, Monte MJ, G Marin JJ, ... Davis RJ, et al. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601222 DOI: 10.1073/Pnas.2002672117  0.378
2020 Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, Chen C, Haybaeck J, de Bruin A, Avila MA, Boekschoten MV, Davis RJ, Trautwein C. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatology Communications. 4: 834-851. PMID 32490320 DOI: 10.1002/hep4.1495  0.373
2020 van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. Plos One. 15: e0226904. PMID 31935227 DOI: 10.1371/Journal.Pone.0226904  0.379
2019 Kant S, Craige SM, Chen K, Reif MM, Learnard H, Kelly M, Caliz AD, Tran KV, Ramo K, Peters OM, Freeman M, Davis RJ, Keaney JF. Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis. Nature Communications. 10: 4223. PMID 31530804 DOI: 10.1038/S41467-019-11982-4  0.396
2019 Dittmann A, Kennedy NJ, Soltero NL, Morshed N, Mana MD, Yilmaz ÖH, Davis RJ, White FM. High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network. Molecular Systems Biology. 15: e8849. PMID 31464373 DOI: 10.15252/Msb.20198849  0.354
2019 Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK represses Lkb-deficiency-induced lung squamous cell carcinoma progression. Nature Communications. 10: 2148. PMID 31089135 DOI: 10.1038/S41467-019-09843-1  0.373
2019 Jangalwe S, Kapoor VN, Xu J, Girnius N, Kennedy NJ, Edwards YJK, Welsh RM, Davis RJ, Brehm MA. Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. Journal of Immunology (Baltimore, Md. : 1950). PMID 30610162 DOI: 10.4049/Jimmunol.1800278  0.314
2019 Mohamed MR, Cubero FJ, Zhao G, Nevzorova YA, Gassler N, Davis RJ, Trautwein C. THU-018-c-Jun N-terminal kinases act synergistically in hepatocytes to protect mice from cholestatic liver injury Journal of Hepatology. 70: e168. DOI: 10.1016/S0618-8278(19)30302-0  0.339
2018 Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC. IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5. Science Signaling. 11. PMID 30459284 DOI: 10.1126/Scisignal.Aap9921  0.454
2018 Calamaras TD, Baumgartner RA, Aronovitz MJ, McLaughlin AL, Tam K, Richards DA, Cooper CW, Li N, Baur WE, Qiao X, Wang GR, Davis RJ, Kapur NK, Karas RH, Blanton RM. Mixed Lineage Kinase 3 (MLK3) Prevents Cardiac Dysfunction and Structural Remodeling with Pressure Overload. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30362822 DOI: 10.1152/Ajpheart.00029.2018  0.36
2018 Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold K, Koczorowska MM, Biniossek M, Kist M, Busch H, Boerries M, Davis RJ, Maurer U, Schilling O, et al. Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin. Nature Communications. 9: 3524. PMID 30166526 DOI: 10.1038/S41467-018-05850-W  0.435
2018 Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH-Terminal Kinase signaling pathway in starvation-induced autophagy. Autophagy. PMID 29950132 DOI: 10.1080/15548627.2018.1466013  0.456
2018 Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 7. PMID 29856313 DOI: 10.7554/Elife.36389  0.342
2018 Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29540552 DOI: 10.1523/Jneurosci.1913-17.2018  0.345
2018 Girnius N, Edwards YJK, Davis RJ. The cJUN NH-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death and Differentiation. PMID 29511338 DOI: 10.1038/S41418-018-0081-Z  0.473
2018 Girnius N, Edwards YJ, Garlick DS, Davis RJ. Author response: The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation Elife. DOI: 10.7554/Elife.36389.044  0.389
2017 Girnius N, Davis RJ. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Reports. 21: 1910-1921. PMID 29141222 DOI: 10.1016/J.Celrep.2017.10.067  0.429
2017 Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Reports. 20: 2775-2783. PMID 28930674 DOI: 10.1016/J.Celrep.2017.08.025  0.465
2017 Xu P, Davis RJ. Correction for Xu and Davis, "c-Jun NH2-Terminal Kinase Is Required for Lineage-Specific Differentiation but Not Stem Cell Self-Renewal". Molecular and Cellular Biology. 37. PMID 28801454 DOI: 10.1128/Mcb.00280-17  0.331
2017 Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, ... ... Davis RJ, et al. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metabolism. 26: 212-229.e12. PMID 28683288 DOI: 10.1016/J.Cmet.2017.06.014  0.364
2017 Wang J, Kho DH, Zhou JY, Davis RJ, Wu GS. MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance. Oncogene. PMID 28650468 DOI: 10.1038/Onc.2017.197  0.351
2017 Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, ... ... Davis RJ, et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 31: 771-789.e6. PMID 28609656 DOI: 10.1016/J.Ccell.2017.05.006  0.336
2017 Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28561373 DOI: 10.1002/Jbmr.3184  0.398
2017 Colleoni B, Paternot S, Pita JM, Bisteau X, Coulonval K, Davis RJ, Raspé E, Roger PP. JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21. Oncogene. PMID 28368408 DOI: 10.1038/Onc.2017.7  0.449
2017 Mandić AD, Bennek E, Verdier J, Zhang K, Roubrocks S, Davis RJ, Denecke B, Gassler N, Streetz K, Kel A, Hornef M, Cubero FJ, Trautwein C, Sellge G. P041 C-jun n-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. Journal of Crohn's & Colitis. 11: S99. PMID 28172553 DOI: 10.1093/Ecco-Jcc/Jjx002.167  0.409
2017 Mandić AD, Bennek E, Verdier J, Zhang K, Roubrocks S, Davis RJ, Denecke B, Gassler N, Streetz K, Kel A, Hornef M, Cubero FJ, Trautwein C, Sellge G. c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine. Mucosal Immunology. PMID 28098247 DOI: 10.1038/Mi.2016.125  0.391
2016 Whitmarsh AJ, Davis RJ. Multisite phosphorylation by MAPK. Science (New York, N.Y.). 354: 179-180. PMID 27738159 DOI: 10.1126/Science.Aai9381  0.445
2016 Hotamisligil GS, Davis RJ. Cell Signaling and Stress Responses. Cold Spring Harbor Perspectives in Biology. 8. PMID 27698029 DOI: 10.1101/Cshperspect.A006072  0.337
2016 Ramo K, Sugamura K, Craige S, Keaney J, Davis RJ. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife. 5. PMID 27504807 DOI: 10.7554/Elife.18414  0.327
2016 Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, Fitzgerald TJ, Altieri DC, et al. αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer Through JNK1-Mediated Activation of Androgen Receptor. Cancer Research. PMID 27450452 DOI: 10.1158/0008-5472.Can-16-0543  0.334
2016 Sayeed A, Lu H, Liu Q, Deming Ii D, Duffy A, McCue P, Dicker AP, Davis RJ, Gabrilovich D, Rodeck U, Altieri DC, Languino LR. β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation. Oncotarget. PMID 27438371 DOI: 10.18632/Oncotarget.10522  0.332
2016 Han MS, Barrett T, Brehm MA, Davis RJ. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Reports. PMID 27052181 DOI: 10.1016/J.Celrep.2016.03.008  0.349
2016 Vernia S, Cavanagh-Kyros J, Barrett T, Tournier C, Davis RJ. Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK. Cell Reports. 14: 2273-80. PMID 26947074 DOI: 10.1016/J.Celrep.2016.02.026  0.347
2016 Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 5. PMID 26910012 DOI: 10.7554/Elife.10031  0.354
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Davis RJ, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.463
2016 Girnius N, Davis RJ. TNFα-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38α MAPK Pathway. Cancer Cell. 29: 131-3. PMID 26859448 DOI: 10.1016/J.Ccell.2016.01.008  0.327
2016 Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Reports. PMID 26832411 DOI: 10.1016/J.Celrep.2015.12.104  0.323
2016 Thornton TM, Delgado P, Chen L, Salas B, Krementsov D, Fernandez M, Vernia S, Davis RJ, Heimann R, Teuscher C, Krangel MS, Ramiro AR, Rincón M. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nature Communications. 7: 10553. PMID 26822034 DOI: 10.1038/Ncomms10553  0.418
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Davis RJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.513
2016 Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Author response: Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress Elife. DOI: 10.7554/Elife.10031.017  0.328
2015 Cubero FJ, Eugenio Zoubek M, Peng J, Hu W, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, et al. Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury. Gastroenterology. PMID 26708719 DOI: 10.1053/J.Gastro.2015.12.019  0.348
2015 Margevicius DR, Bastian C, Fan Q, Davis RJ, Pimplikar SW. JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice. Neurobiology of Aging. 36: 2370-9. PMID 26022769 DOI: 10.1016/J.Neurobiolaging.2015.04.013  0.311
2015 Nisticò R, Florenzano F, Mango D, Ferraina C, Grilli M, Di Prisco S, Nobili A, Saccucci S, D'Amelio M, Morbin M, Marchi M, Mercuri NB, Davis RJ, Pittaluga A, Feligioni M. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. Scientific Reports. 5: 9035. PMID 25762148 DOI: 10.1038/Srep09035  0.378
2015 Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, Tessier-Lavigne M. Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 160: 161-76. PMID 25594179 DOI: 10.1016/J.Cell.2014.11.053  0.344
2015 Schaefer FM, Peng J, Hu W, Drvarov O, Nevzorova YA, Zhao G, Masaoudi MA, Davis RJ, Trautwein C, Cubero FJ. Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration. Biochimica Et Biophysica Acta. 1852: 137-45. PMID 25445542 DOI: 10.1016/J.Bbadis.2014.10.011  0.354
2015 Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH. p38α MAPK is required for tooth morphogenesis and enamel secretion. The Journal of Biological Chemistry. 290: 284-95. PMID 25406311 DOI: 10.1074/Jbc.M114.599274  0.354
2015 Calamaras T, Baumgartner R, Wang G, Davis R, Aronovitz M, Kass D, Karas R, Blanton RM. Mixed linage kinase 3 functions as a cGMP-dependent protein kinase I alpha substrate and regulates blood pressure and cardiac remodeling in vivo Bmc Clinical Pharmacology. 16: 1-2. DOI: 10.1186/2050-6511-16-S1-A24  0.32
2015 Cubero F, Zoubek M, Hu W, Zhao G, Peng J, Nevzorova Y, Masaoudi MA, Bechmann L, Boekschoten M, Muller M, Preisinger C, Gassler N, Canbay A, Luedde T, Davis R, et al. Kombinierte Aktivitäten von JNK1 und JNK2 in Hepatozyten schützen vor Toxin-induzierten Leberschädigung Zeitschrift Fur Gastroenterologie. 53. DOI: 10.1055/S-0035-1568040  0.352
2014 Vernia S, Cavanagh-Kyros J, Garcia-Haro L, Sabio G, Barrett T, Jung DY, Kim JK, Xu J, Shulha HP, Garber M, Gao G, Davis RJ. The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway. Cell Metabolism. 20: 512-25. PMID 25043817 DOI: 10.1016/J.Cmet.2014.06.010  0.373
2014 Zaidi SK, Shen WJ, Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. Journal of Molecular Endocrinology. 53: 1-16. PMID 24780837 DOI: 10.1530/Jme-13-0287  0.348
2014 Maimon A, Mogilevsky M, Shilo A, Golan-Gerstl R, Obiedat A, Ben-Hur V, Lebenthal-Loinger I, Stein I, Reich R, Beenstock J, Zehorai E, Andersen CL, Thorsen K, Ørntoft TF, Davis RJ, et al. Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation Cell Reports. 7: 501-513. PMID 24726367 DOI: 10.1016/J.Celrep.2014.03.041  0.402
2014 Davies CC, Harvey E, McMahon RFT, Finegan KG, Connor F, Davis RJ, Tuveson DA, Tournier C. Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma Cancer Research. 74: 3344-3356. PMID 24713432 DOI: 10.1016/J.Pan.2015.05.156  0.445
2014 Sabio G, Davis RJ. TNF and MAP kinase signalling pathways Seminars in Immunology. 26: 237-245. PMID 24647229 DOI: 10.1016/J.Smim.2014.02.009  0.48
2014 Zhao G, Hatting M, Nevzorova YA, Peng J, Hu W, Boekschoten MV, Roskams T, Muller M, Gassler N, Liedtke C, Davis RJ, Cubero FJ, Trautwein C. Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis Gut. 63: 1159-1172. PMID 24037431 DOI: 10.1136/Gutjnl-2013-305507  0.34
2013 Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway Genes and Development. 27: 2345-2355. PMID 24186979 DOI: 10.1101/Gad.223800.113  0.346
2013 Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ. Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity. Cell Reports. 4: 681-8. PMID 23954791 DOI: 10.1016/J.Celrep.2013.07.019  0.391
2013 Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death and Differentiation. 20: 1317-29. PMID 23832115 DOI: 10.1038/Cdd.2013.78  0.432
2013 You H, Padmashali RM, Ranganathan A, Lei P, Girnius N, Davis RJ, Andreadis ST. JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues. Journal of Cell Science. 126: 2718-29. PMID 23591817 DOI: 10.1242/Jcs.122903  0.408
2013 Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA, Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford DA, Davis RJ, Bornfeldt KE. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. The Journal of Biological Chemistry. 288: 9957-70. PMID 23426369 DOI: 10.1074/Jbc.M113.458372  0.342
2013 Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. The Journal of Biological Chemistry. 288: 3823-30. PMID 23269672 DOI: 10.1074/Jbc.M112.397885  0.451
2013 Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (New York, N.Y.). 339: 218-22. PMID 23223452 DOI: 10.1126/Science.1227568  0.317
2013 González-Terán B, Cortés JR, Manieri E, Matesanz N, Verdugo Á, Rodríguez ME, González-Rodríguez Á, Valverde ÁM, Valverde Á, Martín P, Davis RJ, Sabio G. Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis. The Journal of Clinical Investigation. 123: 164-78. PMID 23202732 DOI: 10.1172/Jci65124  0.328
2013 Blanton R, Lane A, Aronovitz M, Wang G, Thoonen R, Davis R, Mendelsohn M, Kass D, Karas R. Identification of protein kinase G I alpha interacting proteins as potential targets to prevent cardiac remodeling Bmc Clinical Pharmacology. 14: 10. DOI: 10.1186/2050-6511-14-S1-P10  0.32
2013 Blanton RM, Lane A, Aronovitz M, Wang G, Thoonen R, Davis R, Mendelsohn M, Kass D, Karas R. Identification of Novel Protein Kinase G I alpha Interacting Proteins as Potential Targets To Prevent Cardiac Remodeling Journal of Cardiac Failure. 19: S1. DOI: 10.1016/J.Cardfail.2013.06.010  0.337
2012 Davis RJ. Cell biology. A scaffold switch to insulate. Science (New York, N.Y.). 337: 1178-9. PMID 22955821 DOI: 10.1126/Science.1227747  0.349
2012 Llopis A, Salvador N, Ercilla A, Guaita-Esteruelas S, Barrantes Idel B, Gupta J, Gaestel M, Davis RJ, Nebreda AR, Agell N. The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest. Cell Cycle (Georgetown, Tex.). 11: 3627-37. PMID 22935704 DOI: 10.4161/Cc.21917  0.388
2012 Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discovery. 2: 906-21. PMID 22777769 DOI: 10.1158/2159-8290.Cd-12-0085  0.312
2012 Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proceedings of the National Academy of Sciences of the United States of America. 109: 12046-51. PMID 22753496 DOI: 10.1073/Pnas.1209660109  0.325
2012 Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Molecular and Cellular Biology. 32: 2010-9. PMID 22431523 DOI: 10.1128/Mcb.06193-11  0.348
2012 Clybouw C, Merino D, Nebl T, Masson F, Robati M, O'Reilly L, Hübner A, Davis RJ, Strasser A, Bouillet P. Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo. Cell Death and Differentiation. 19: 1060-8. PMID 22240894 DOI: 10.1038/Cdd.2011.198  0.427
2012 Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Research. 72: 472-81. PMID 22127926 DOI: 10.1158/0008-5472.Can-11-1628  0.332
2012 Flavell RA, Dong C, Davis RJ. Erratum to: Signaling and cell death in lymphocytes Inflammation Research. 61: 1167-1167. DOI: 10.1007/S00011-012-0525-8  0.305
2011 Mazzitelli S, Xu P, Ferrer I, Davis RJ, Tournier C. The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16969-76. PMID 22114267 DOI: 10.1523/Jneurosci.4491-11.2011  0.367
2011 Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes & Development. 25: 2069-78. PMID 21979919 DOI: 10.1101/Gad.17224711  0.473
2011 Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. The Journal of Clinical Investigation. 121: 4383-92. PMID 21965325 DOI: 10.1172/Jci59041  0.397
2011 Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nature Medicine. 17: 1251-60. PMID 21892182 DOI: 10.1038/Nm.2449  0.417
2011 Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C. Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood. 118: 3290-300. PMID 21791428 DOI: 10.1182/Blood-2011-02-336552  0.377
2011 Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, Whittaker LA, Rincon M. Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 45: 1133-41. PMID 21642586 DOI: 10.1165/Rcmb.2011-0054Oc  0.321
2011 Wen HC, Avivar-Valderas A, Sosa MS, Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA. p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Science Signaling. 4: ra34. PMID 21610252 DOI: 10.1126/Scisignal.2001684  0.455
2011 Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. The Journal of Biological Chemistry. 286: 22227-34. PMID 21540183 DOI: 10.1074/Jbc.M111.228874  0.422
2011 Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes & Development. 25: 634-45. PMID 21406557 DOI: 10.1101/Gad.1989311  0.338
2011 Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE. Translational control of NKT cell cytokine production by p38 MAPK. Journal of Immunology (Baltimore, Md. : 1950). 186: 4140-6. PMID 21368234 DOI: 10.4049/Jimmunol.1002614  0.395
2011 Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes & Development. 25: 310-22. PMID 21325132 DOI: 10.1101/Gad.1984311  0.359
2011 Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. Journal of Molecular and Cellular Cardiology. 50: 702-11. PMID 21284947 DOI: 10.1016/J.Yjmcc.2011.01.013  0.369
2011 Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ. Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation. Molecular and Cellular Biology. 31: 1565-76. PMID 21282468 DOI: 10.1128/Mcb.01122-10  0.415
2010 Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nature Cell Biology. 12: 1242-9. PMID 21102438 DOI: 10.1038/Ncb2130  0.475
2010 Sherrin T, Blank T, Hippel C, Rayner M, Davis RJ, Todorovic C. Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13348-61. PMID 20926661 DOI: 10.1523/Jneurosci.3492-10.2010  0.385
2010 Cellurale C, Weston CR, Reilly J, Garlick DS, Jerry DJ, Sluss HK, Davis RJ. Role of JNK in a Trp53-dependent mouse model of breast cancer. Plos One. 5: e12469. PMID 20814571 DOI: 10.1371/Journal.Pone.0012469  0.333
2010 Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Molecular and Cellular Biology. 30: 4616-25. PMID 20679483 DOI: 10.1128/Mcb.00585-10  0.458
2010 Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, ... Davis R, et al. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. The Journal of Clinical Investigation. 120: 2457-73. PMID 20551513 DOI: 10.1172/Jci42285  0.433
2010 Barnat M, Enslen H, Propst F, Davis RJ, Soares S, Nothias F. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7804-16. PMID 20534829 DOI: 10.1523/Jneurosci.0372-10.2010  0.415
2010 Sabio G, Davis RJ. cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends in Biochemical Sciences. 35: 490-6. PMID 20452774 DOI: 10.1016/J.Tibs.2010.04.004  0.321
2010 Gutierrez GJ, Tsuji T, Cross JV, Davis RJ, Templeton DJ, Jiang W, Ronai ZA. JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint. The Journal of Biological Chemistry. 285: 14217-28. PMID 20220133 DOI: 10.1074/Jbc.M110.121848  0.458
2010 Podkowa M, Zhao X, Chow CW, Coffey ET, Davis RJ, Attisano L. Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. Molecular and Cellular Biology. 30: 2241-50. PMID 20176805 DOI: 10.1128/Mcb.01166-09  0.343
2010 Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes & Development. 24: 256-64. PMID 20080940 DOI: 10.1101/Gad.1878510  0.32
2010 Xu P, Davis RJ. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Molecular and Cellular Biology. 30: 1329-40. PMID 20065035 DOI: 10.1128/Mcb.00795-09  0.397
2010 Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A. Differential activation of p38MAPK isoforms by MKK6 and MKK3. Cellular Signalling. 22: 660-7. PMID 20004242 DOI: 10.1016/J.Cellsig.2009.11.020  0.462
2010 Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance Molecular and Cellular Biology. 30: 106-115. PMID 19841069 DOI: 10.1128/Mcb.01162-09  0.316
2010 Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Molecular and Cellular Biology. 30: 98-105. PMID 19841067 DOI: 10.1128/Mcb.01155-09  0.449
2010 Davis RJ. Correction. Science (New York, N.Y.). 269: 17. PMID 17787682 DOI: 10.1126/Science.269.5220.17-A  0.356
2010 Davis R. KL2 Signal transduction by the JNK pathway Cytokine. 52: 35. DOI: 10.1016/J.Cyto.2010.07.426  0.345
2010 Kennedy NJ, Davis RJ. Mammalian MAP kinases Handbook of Cell Signaling, 2/E. 2: 1315-1328. DOI: 10.1016/B978-0-12-374145-5.00164-9  0.361
2009 Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metabolism. 10: 491-8. PMID 19945406 DOI: 10.1016/J.Cmet.2009.09.007  0.307
2009 Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes Molecular and Cellular Biology. 29: 4831-4840. PMID 19564410 DOI: 10.1128/Mcb.00155-09  0.421
2009 Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS. Role of MAPK Kinase 6 in Arthritis: Distinct Mechanism of Action in Inflammation and Cytokine Expression Journal of Immunology. 183: 1360-1367. PMID 19561096 DOI: 10.4049/Jimmunol.0900483  0.354
2009 Morel C, Carlson SM, White FM, Davis RJ. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Molecular and Cellular Biology. 29: 3845-52. PMID 19433446 DOI: 10.1128/Mcb.00279-09  0.491
2009 Rincón M, Davis RJ. Regulation of the immune response by stress-activated protein kinases. Immunological Reviews. 228: 212-24. PMID 19290930 DOI: 10.1111/J.1600-065X.2008.00744.X  0.415
2009 Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 136: 249-60. PMID 19167327 DOI: 10.1016/J.Cell.2008.11.017  0.344
2009 Klevernic IV, Morton S, Davis RJ, Cohen P. Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage. The Biochemical Journal. 418: 625-34. PMID 19076070 DOI: 10.1042/Bj20082097  0.449
2009 Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, Davis RJ, Tesch GH. Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. Diabetologia. 52: 347-58. PMID 19066844 DOI: 10.1007/S00125-008-1215-5  0.394
2008 Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (New York, N.Y.). 322: 1539-43. PMID 19056984 DOI: 10.1126/Science.1160794  0.339
2008 Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Science Signaling. 1: ra14. PMID 19036714 DOI: 10.1126/Scisignal.1161938  0.461
2008 Harvey CD, Ehrhardt AG, Cellurale C, Zhong H, Yasuda R, Davis RJ, Svoboda K. A genetically encoded fluorescent sensor of ERK activity. Proceedings of the National Academy of Sciences of the United States of America. 105: 19264-9. PMID 19033456 DOI: 10.1073/Pnas.0804598105  0.412
2008 Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis. 29: 2317-24. PMID 18952597 DOI: 10.1093/Carcin/Bgn239  0.381
2008 Hübner A, Barrett T, Flavell RA, Davis RJ. Multisite phosphorylation regulates Bim stability and apoptotic activity. Molecular Cell. 30: 415-25. PMID 18498746 DOI: 10.1016/J.Molcel.2008.03.025  0.476
2008 Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation Science. 320: 667-670. PMID 18451303 DOI: 10.1126/Science.1156037  0.472
2008 Alcorn JF, Guala AS, van der Velden J, McElhinney B, Irvin CG, Davis RJ, Janssen-Heininger YM. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. Journal of Cell Science. 121: 1036-45. PMID 18334556 DOI: 10.1242/Jcs.019455  0.305
2008 Fukuda K, Tesch GH, Yap FY, Forbes JM, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 398-407. PMID 18283273 DOI: 10.1038/Labinvest.2008.10  0.408
2008 Escors D, Lopes L, Lin R, Hiscott J, Akira S, Davis RJ, Collins MK. Targeting dendritic cell signaling to regulate the response to immunization. Blood. 111: 3050-61. PMID 18180378 DOI: 10.1182/Blood-2007-11-122408  0.366
2008 Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. The Biochemical Journal. 409: 711-22. PMID 18021073 DOI: 10.1042/Bj20071149  0.482
2008 Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection and Immunity. 76: 308-16. PMID 17998313 DOI: 10.1128/Iai.00599-07  0.302
2008 Keramaris E, Ruzhynsky VA, Callaghan SM, Wong E, Davis RJ, Flavell R, Slack RS, Park DS. Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. The Journal of Biological Chemistry. 283: 405-15. PMID 17984095 DOI: 10.1074/Jbc.M701552200  0.382
2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/Pnas.0707782104  0.416
2007 Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes & Development. 21: 2336-46. PMID 17875667 DOI: 10.1101/Gad.1563107  0.357
2007 Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, ... ... Davis RJ, et al. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 27: 349-60. PMID 17723219 DOI: 10.1016/J.Immuni.2007.07.011  0.334
2007 Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. American Journal of Physiology. Renal Physiology. 293: F1556-63. PMID 17686961 DOI: 10.1152/Ajprenal.00010.2007  0.362
2007 Jaeschke A, Davis RJ. Metabolic Stress Signaling Mediated by Mixed-Lineage Kinases Molecular Cell. 27: 498-508. PMID 17679097 DOI: 10.1016/J.Molcel.2007.07.008  0.475
2007 Izadi H, Motameni AT, Bates TC, Olivera ER, Villar-Suarez V, Joshi I, Garg R, Osborne BA, Davis RJ, Rincón M, Anguita J. c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages. Infection and Immunity. 75: 5027-34. PMID 17664270 DOI: 10.1128/Iai.00492-07  0.384
2007 Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. The American Journal of Pathology. 171: 297-303. PMID 17591974 DOI: 10.2353/Ajpath.2007.061036  0.426
2007 Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 11: 555-69. PMID 17560336 DOI: 10.1016/J.Ccr.2007.04.021  0.427
2007 Whitmarsh AJ, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer Oncogene. 26: 3172-3184. PMID 17496914 DOI: 10.1038/Sj.Onc.1210410  0.479
2007 Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. A semisynthetic epitope for kinase substrates. Nature Methods. 4: 511-6. PMID 17486086 DOI: 10.1038/Nmeth1048  0.449
2007 Clark JE, Flavell RA, Faircloth ME, Davis RJ, Heads RJ, Marber MS. Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3). Cardiovascular Research. 74: 466-70. PMID 17399693 DOI: 10.1016/J.Cardiores.2007.02.027  0.42
2007 Weston CR, Davis RJ. The JNK signal transduction pathway. Current Opinion in Cell Biology. 19: 142-9. PMID 17303404 DOI: 10.1016/J.Ceb.2007.02.001  0.461
2007 Kennedy NJ, Cellurale C, Davis RJ. A Radical Role for p38 MAPK in Tumor Initiation Cancer Cell. 11: 101-103. PMID 17292820 DOI: 10.1016/J.Ccr.2007.01.009  0.349
2007 Rincón M, Davis RJ. Choreography of MAGUKs during T cell activation. Nature Immunology. 8: 126-7. PMID 17242684 DOI: 10.1038/Ni0207-126  0.452
2007 Hübner A, Jaeschke A, Davis RJ. Oncogene addiction: role of signal attenuation. Developmental Cell. 11: 752-4. PMID 17141149 DOI: 10.1016/J.Devcel.2006.11.006  0.321
2007 Clark J, Flavell R, Faircloth M, Davis R, Marber M. Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) Journal of Molecular and Cellular Cardiology. 42: S52-S53. DOI: 10.1016/J.Yjmcc.2007.03.149  0.447
2006 Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ, Sethi T, Simpson KJ. Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. Gut. 56: 982-90. PMID 17185352 DOI: 10.1136/Gut.2006.104372  0.429
2006 Chow CW, Davis RJ. Proteins kinases: chromatin-associated enzymes? Cell. 127: 887-90. PMID 17129776 DOI: 10.1016/J.Cell.2006.11.015  0.38
2006 Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proceedings of the National Academy of Sciences of the United States of America. 103: 16313-8. PMID 17060633 DOI: 10.1073/Pnas.0602557103  0.371
2006 Groisman I, Ivshina M, Marin V, Kennedy NJ, Davis RJ, Richter JD. Control of cellular senescence by CPEB. Genes & Development. 20: 2701-12. PMID 17015432 DOI: 10.1101/Gad.1438906  0.325
2006 Khurana A, Nakayama K, Williams S, Davis RJ, Mustelin T, Ronai Z. Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. The Journal of Biological Chemistry. 281: 35316-26. PMID 17003045 DOI: 10.1074/Jbc.M606568200  0.428
2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/J.Molcel.2006.07.028  0.434
2006 Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 103: 13451-6. PMID 16938889 DOI: 10.1073/Pnas.0601155103  0.361
2006 Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, et al. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. The American Journal of Pathology. 169: 566-83. PMID 16877357 DOI: 10.2353/Ajpath.2006.051066  0.326
2006 Bellahcene M, Jacquet S, Cao XB, Tanno M, Haworth RS, Layland J, Kabir AM, Gaestel M, Davis RJ, Flavell RA, Shah AM, Avkiran M, Marber MS. Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor. Journal of the American College of Cardiology. 48: 545-55. PMID 16875982 DOI: 10.1016/J.Jacc.2006.02.072  0.406
2006 Sluss HK, Davis RJ. H2AX Is a Target of the JNK Signaling Pathway that Is Required For Apoptotic DNA Fragmentation Molecular Cell. 23: 152-153. PMID 16857581 DOI: 10.1016/J.Molcel.2006.07.001  0.346
2006 Young JK, Seit-Nebi A, Davis RJ, Han J. Multiple activation mechanisms of p38α mitogen-activated protein kinase Journal of Biological Chemistry. 281: 26225-26234. PMID 16849316 DOI: 10.1074/Jbc.M606800200  0.487
2006 Jaeschke A, Davis RJ. Chemical genetic analysis of signal transduction pathways Expert Opinion On Therapeutic Targets. 10: 485-488. PMID 16848685 DOI: 10.1517/14728222.10.4.485  0.334
2006 Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL. Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 26: 284-9. PMID 16847457 DOI: 10.1038/Sj.Onc.1209781  0.374
2006 Giafis N, Katsoulidis E, Sassano A, Tallman MS, Higgins LS, Nebreda AR, Davis RJ, Platanias LC. Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses. Cancer Research. 66: 6763-71. PMID 16818652 DOI: 10.1158/0008-5472.Can-05-3699  0.422
2006 Tachibana H, Perrino C, Takaoka H, Davis RJ, Naga Prasad SV, Rockman HA. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochemical and Biophysical Research Communications. 343: 1060-6. PMID 16579967 DOI: 10.1016/J.Bbrc.2006.03.065  0.339
2006 Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 103: 5484-9. PMID 16567640 DOI: 10.1073/Pnas.0509188103  0.381
2006 Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Molecular Cell. 21: 701-10. PMID 16507367 DOI: 10.1016/J.Molcel.2006.01.018  0.396
2006 Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, et al. Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. The Journal of Experimental Medicine. 203: 371-81. PMID 16446383 DOI: 10.1084/Jem.20052242  0.408
2005 Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, Flavell R, Tabas I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. The Journal of Cell Biology. 171: 61-73. PMID 16203857 DOI: 10.1083/Jcb.200502078  0.375
2005 Kabir AMN, Cao X, Gorog DA, Tanno M, Bassi R, Bellahcene M, Quinlan RA, Davis RJ, Flavell RA, Shattock MJ, Marber MS. Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3 Journal of Molecular and Cellular Cardiology. 39: 709-717. PMID 16140323 DOI: 10.1016/J.Yjmcc.2005.07.012  0.387
2005 Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Molecular and Cellular Biology. 25: 4853-62. PMID 15923604 DOI: 10.1128/Mcb.25.12.4853-4862.2005  0.393
2005 Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 102: 6931-5. PMID 15867147 DOI: 10.1073/Pnas.0502143102  0.31
2005 Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Molecular and Cellular Biology. 25: 3670-81. PMID 15831472 DOI: 10.1128/Mcb.25.9.3670-3681.2005  0.516
2005 Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. The Journal of Biological Chemistry. 280: 21763-72. PMID 15826936 DOI: 10.1074/Jbc.M501759200  0.406
2005 Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Molecular and Cellular Biology. 25: 2733-43. PMID 15767678 DOI: 10.1128/Mcb.25.7.2733-2743.2005  0.472
2005 Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proceedings of the National Academy of Sciences of the United States of America. 102: 4494-9. PMID 15767565 DOI: 10.1073/Pnas.0500749102  0.418
2005 Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan CY, Vaudano E, Behrens A, Wagner E, ... ... Davis RJ, et al. Specific pathophysiological functions of JNK isoforms in the brain. The European Journal of Neuroscience. 21: 363-77. PMID 15673436 DOI: 10.1111/J.1460-9568.2005.03857.X  0.358
2005 Li Y, Batra S, Sassano A, Majchrzak B, Levy DE, Gaestel M, Fish EN, Davis RJ, Platanias LC. Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons. The Journal of Biological Chemistry. 280: 10001-10. PMID 15644321 DOI: 10.1074/Jbc.M410972200  0.374
2005 Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. The Journal of Biological Chemistry. 280: 1132-41. PMID 15528206 DOI: 10.1074/Jbc.M410127200  0.355
2004 Whitmarsh AJ, Davis RJ. Analyzing mitogen-activated protein kinase (MAPK) activities in T cells Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. PMID 18432922 DOI: 10.1002/0471142735.Im1108S58  0.459
2004 Ventura JJ, Cogswell P, Flavell RA, Baldwin AS, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes & Development. 18: 2905-15. PMID 15545623 DOI: 10.1101/Gad.1223004  0.359
2004 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis Proceedings of the National Academy of Sciences of the United States of America. 101: 14114-14119. PMID 15375216 DOI: 10.1073/Pnas.0406061101  0.458
2004 Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes & Development. 18: 1976-80. PMID 15314024 DOI: 10.1101/Gad.1216504  0.569
2004 Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 430: 793-7. PMID 15306813 DOI: 10.1038/Nature02764  0.402
2004 Morton S, Davis RJ, Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. Febs Letters. 572: 177-83. PMID 15304344 DOI: 10.1016/J.Febslet.2004.07.031  0.497
2004 Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ. JNK regulates autocrine expression of TGF-β1 Molecular Cell. 15: 269-278. PMID 15260977 DOI: 10.1016/J.Molcel.2004.06.007  0.326
2004 Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. The Embo Journal. 23: 1576-86. PMID 15044949 DOI: 10.1038/Sj.Emboj.7600173  0.429
2004 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 665-70. PMID 14704277 DOI: 10.1073/Pnas.0307453101  0.317
2003 Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 100: 15184-9. PMID 14657393 DOI: 10.1073/Pnas.2336254100  0.391
2003 Xiu M, Kim J, Sampson E, Huang CY, Davis RJ, Paulson KE, Yee AS. The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. Molecular and Cellular Biology. 23: 8890-901. PMID 14612426 DOI: 10.1128/Mcb.23.23.8890-8901.2003  0.465
2003 Lee TH, Huang Q, Oikemus S, Shank J, Ventura JJ, Cusson N, Vaillancourt RR, Su B, Davis RJ, Kelliher MA. The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Molecular and Cellular Biology. 23: 8377-85. PMID 14585994 DOI: 10.1128/Mcb.23.22.8377-8385.2003  0.429
2003 Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annual Review of Cell and Developmental Biology. 19: 91-118. PMID 14570565 DOI: 10.1146/Annurev.Cellbio.19.111401.091942  0.492
2003 Salas TR, Reddy SA, Clifford JL, Davis RJ, Kikuchi A, Lippman SM, Menter DG. Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei. The Journal of Biological Chemistry. 278: 41338-46. PMID 12900420 DOI: 10.1074/Jbc.M302972200  0.366
2003 Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proceedings of the National Academy of Sciences of the United States of America. 100: 9843-8. PMID 12897243 DOI: 10.1073/Pnas.1733944100  0.375
2003 Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes & Development. 17: 1969-78. PMID 12893778 DOI: 10.1101/Gad.1107303  0.48
2003 Morton S, Davis RJ, McLaren A, Cohen P. A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. The Embo Journal. 22: 3876-86. PMID 12881422 DOI: 10.1093/Emboj/Cdg388  0.463
2003 Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. The Journal of Biological Chemistry. 278: 36993-8. PMID 12857751 DOI: 10.1074/Jbc.M302942200  0.316
2003 Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS. Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circulation Research. 93: 254-61. PMID 12829618 DOI: 10.1161/01.Res.0000083490.43943.85  0.393
2003 Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Molecular Cell. 11: 1479-89. PMID 12820962 DOI: 10.1016/S1097-2765(03)00203-X  0.404
2003 Manning AM, Davis RJ. Targeting JNK for therapeutic benefit: From junk to gold? Nature Reviews Drug Discovery. 2: 554-565. PMID 12815381 DOI: 10.1038/Nrd1132  0.414
2003 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure Genes and Development. 17: 1271-1280. PMID 12756228 DOI: 10.1101/Gad.1087303  0.405
2003 Zhang X, Shan P, Alam J, Davis RJ, Flavell RA, Lee PJ. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. The Journal of Biological Chemistry. 278: 22061-70. PMID 12690100 DOI: 10.1074/Jbc.M301858200  0.37
2003 Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor Molecular and Cellular Biology. 23: 2871-2882. PMID 12665585 DOI: 10.1128/Mcb.23.8.2871-2882.2003  0.434
2003 Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L250-7. PMID 12651633 DOI: 10.1152/Ajplung.00387.2002  0.359
2003 Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes & Development. 17: 629-37. PMID 12629045 DOI: 10.1101/Gad.1062903  0.404
2003 Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis Proceedings of the National Academy of Sciences of the United States of America. 100: 2432-2437. PMID 12591950 DOI: 10.1073/Pnas.0438011100  0.426
2003 Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. The Journal of Biological Chemistry. 278: 2896-902. PMID 12417588 DOI: 10.1074/Jbc.M208359200  0.429
2003 Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. The Journal of Biological Chemistry. 278: 1248-58. PMID 12399465 DOI: 10.1074/Jbc.M208419200  0.342
2002 Reuther-Madrid JY, Kashatus D, Chen S, Li X, Westwick J, Davis RJ, Earp HS, Wang CY, Baldwin Jr AS. The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Molecular and Cellular Biology. 22: 8175-83. PMID 12417721 DOI: 10.1128/Mcb.22.23.8175-8183.2002  0.426
2002 Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nature Genetics. 32: 201-5. PMID 12161751 DOI: 10.1038/Ng946  0.447
2002 Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. Embo Reports. 3: 785-91. PMID 12151339 DOI: 10.1093/Embo-Reports/Kvf153  0.444
2002 Hall JP, Davis RJ. Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line Journal of Cellular Biochemistry. 86: 1-11. PMID 12112010 DOI: 10.1002/Jcb.10187  0.44
2002 Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. The Journal of Biological Chemistry. 277: 35586-96. PMID 12091388 DOI: 10.1074/Jbc.M204362200  0.407
2002 Weston CR, Lambright DG, Davis RJ. Signal transduction. MAP kinase signaling specificity. Science (New York, N.Y.). 296: 2345-7. PMID 12089430 DOI: 10.1126/Science.1073344  0.434
2002 Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 6352-7. PMID 12055252 DOI: 10.4049/Jimmunol.168.12.6352  0.448
2002 Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Molecular and Cellular Biology. 22: 4929-42. PMID 12052897 DOI: 10.1128/Mcb.22.13.4929-4942.2002  0.408
2002 Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Molecular and Cellular Biology. 22: 3892-904. PMID 11997522 DOI: 10.1128/Mcb.22.11.3892-3904.2002  0.489
2002 Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rincón M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. The Journal of Experimental Medicine. 195: 811-23. PMID 11927626 DOI: 10.1084/Jem.20011508  0.349
2002 Arbour N, Naniche D, Homann D, Davis RJ, Flavell RA, Oldstone MB. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. The Journal of Experimental Medicine. 195: 801-10. PMID 11927625 DOI: 10.1084/Jem.20011481  0.35
2002 Flavell RA, Dong C, Davis RJ. Signaling and cell death in lymphocytes. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 51: 80-2. PMID 11926317 DOI: 10.1007/Bf02684006  0.337
2002 Weston CR, Davis RJ. The JNK signal transduction pathway Current Opinion in Genetics and Development. 12: 14-21. PMID 11790549 DOI: 10.1016/S0959-437X(01)00258-1  0.463
2002 Enslen H, Davis RJ. Regulation of MAP kinases by docking domains. Biology of the Cell. 93: 5-14. PMID 11730322 DOI: 10.1016/S0248-4900(01)01156-X  0.382
2002 Dong C, Davis RJ, Flavell RA. Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase. Journal of Clinical Immunology. 21: 253-7. PMID 11506194 DOI: 10.1023/A:1010975124110  0.431
2001 Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annual Review of Immunology. 20: 55-72. PMID 11861597 DOI: 10.1146/Annurev.Immunol.20.091301.131133  0.371
2001 Hall JP, Davis RJ. Analysis of c-Jun N-terminal kinase regulation and function Methods in Enzymology. 345: 413-425. PMID 11665625 DOI: 10.1016/S0076-6879(02)45034-3  0.506
2001 Whitmarsh AJ, Davis RJ. Signal transduction by target-derived neurotrophins Nature Neuroscience. 4: 963-964. PMID 11574825 DOI: 10.1038/Nn1001-963  0.398
2001 Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7551-60. PMID 11567045 DOI: 10.1523/Jneurosci.21-19-07551.2001  0.327
2001 Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes & Development. 15: 2421-32. PMID 11562351 DOI: 10.1101/Gad.922801  0.445
2001 Kontoyiannis D, Kotlyarov A, Carballo E, Alexopoulou L, Blackshear PJ, Gaestel M, Davis R, Flavell R, Kollias G. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology The Embo Journal. 20: 3760-3770. PMID 11447117 DOI: 10.1093/Emboj/20.14.3760  0.332
2001 Weston CR, Davis RJ. Signaling specificity - A complex affair Science. 292: 2439-2440. PMID 11431552 DOI: 10.1126/Science.1063279  0.429
2001 Rincón M, Flavell RA, Davis RJ. Signal transduction by MAP kinases in T lymphocytes. Oncogene. 20: 2490-7. PMID 11402343 DOI: 10.1038/Sj.Onc.1204382  0.388
2001 Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines Genes and Development. 15: 1419-1426. PMID 11390361 DOI: 10.1101/Gad.888501  0.508
2001 Chen P, Hutter D, Yang X, Gorospe M, Davis RJ, Liu Y. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. The Journal of Biological Chemistry. 276: 29440-9. PMID 11387337 DOI: 10.1074/Jbc.M103463200  0.478
2001 Lu B, Yu H, Chow C, Li B, Zheng W, Davis RJ, Flavell RA. GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity. 14: 583-90. PMID 11371360 DOI: 10.1016/S1074-7613(01)00141-8  0.412
2001 Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. The Journal of Biological Chemistry. 276: 27770-7. PMID 11356842 DOI: 10.1074/Jbc.M102264200  0.36
2001 De Zutter GS, Davis RJ. Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 98: 6168-73. PMID 11344273 DOI: 10.1073/Pnas.111027698  0.459
2001 Whitmarsh AJ, Davis RJ. Analyzing JNK and p38 mitogen-activated protein kinase activity Methods in Enzymology. 332: 319-336. PMID 11305107 DOI: 10.1016/S0076-6879(01)32212-7  0.483
2001 Kasugai K, Watson SJ, Flavell RA, Davis RJ, Todisco A. Crucial role of c-Jun NH2-terminal kinase 1 (JNK1) in cold restraint stress-induced gastric lesions in mice Gastroenterology. 120: A307. DOI: 10.1016/S0016-5085(08)81523-5  0.345
2000 Iordanov MS, Wong J, Newton DL, Rybak SM, Bright RK, Flavell RA, Davis RJ, Magun BE. Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts. Molecular Cell Biology Research Communications : McBrc. 4: 122-8. PMID 11170843 DOI: 10.1006/Mcbr.2000.0266  0.491
2000 Hall JP, Merithew E, Davis RJ. c-Jun N-terminal kinase (JNK) repression during the inflammatory response? Just say NO Proceedings of the National Academy of Sciences of the United States of America. 97: 14022-14024. PMID 11121010 DOI: 10.1073/Pnas.97.26.14022  0.354
2000 McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (New York, N.Y.). 290: 1574-7. PMID 11090355 DOI: 10.1126/Science.290.5496.1574  0.414
2000 Davis RJ. Signal transduction by the JNK group of MAP kinases Cell. 103: 239-252. PMID 11057897 DOI: 10.1016/S0092-8674(00)00116-1  0.444
2000 Whitmarsh AJ, Davis RJ. Regulation of transcription factor function by phosphorylation Cellular and Molecular Life Sciences. 57: 1172-1183. PMID 11028910 DOI: 10.1007/Pl00000757  0.405
2000 Awad MM, Enslen H, Boylan JM, Davis RJ, Gruppuso PA. Growth regulation via p38 mitogen-activated protein kinase in developing liver. The Journal of Biological Chemistry. 275: 38716-21. PMID 10995779 DOI: 10.1074/Jbc.M008040200  0.422
2000 Chow CW, Dong C, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Molecular and Cellular Biology. 20: 5227-34. PMID 10866678 DOI: 10.1128/Mcb.20.14.5227-5234.2000  0.435
2000 Li B, Yu H, Zheng W, Voll R, Na S, Roberts AW, Williams DA, Davis RJ, Ghosh S, Flavell RA. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science (New York, N.Y.). 288: 2219-22. PMID 10864872 DOI: 10.1126/Science.288.5474.2219  0.344
2000 Dong C, Yang DD, Tournier C, Whitmarsh AJ, Xu J, Davis RJ, Flavell RA. JNK is required for effector T-cell function but not for T-cell activation. Nature. 405: 91-4. PMID 10811224 DOI: 10.1038/35011091  0.38
2000 Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway Science. 288: 870-874. PMID 10797012 DOI: 10.1126/Science.288.5467.870  0.416
2000 Rincón M, Conze D, Weiss L, Diehl NL, Fortner KA, Yang D, Flavell RA, Enslen H, Whitmarsh A, Davis RJ. Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways? Immunology and Cell Biology. 78: 166-75. PMID 10762418 DOI: 10.1046/J.1440-1711.2000.00900.X  0.502
2000 Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature Medicine. 6: 422-8. PMID 10742149 DOI: 10.1038/74680  0.317
2000 Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). The Journal of Biological Chemistry. 275: 9047-54. PMID 10722755 DOI: 10.1074/Jbc.275.12.9047  0.443
2000 Enslen H, Brancho DM, Davis RJ. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. The Embo Journal. 19: 1301-11. PMID 10716930 DOI: 10.1093/Emboj/19.6.1301  0.435
2000 Whitmarsh AJ, Davis RJ. A central control for cell growth Nature. 403: 255-256. PMID 10659830 DOI: 10.1038/35002220  0.339
2000 Diehl NL, Enslen H, Fortner KA, Merritt C, Stetson N, Charland C, Flavell RA, Davis RJ, Rincón M. Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo Journal of Experimental Medicine. 191: 321-334. PMID 10637276 DOI: 10.1084/Jem.191.2.321  0.422
2000 Kelkar N, Gupta S, Dickens M, Davis RJ. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Molecular and Cellular Biology. 20: 1030-43. PMID 10629060 DOI: 10.1128/Mcb.20.3.1030-1043.2000  0.499
2000 Merritt C, Enslen H, Diehl N, Conze D, Davis RJ, Rincón M. Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells. Molecular and Cellular Biology. 20: 936-46. PMID 10629051 DOI: 10.1128/Mcb.20.3.936-946.2000  0.379
2000 Weiss L, Whitmarsh AJ, Yang DD, Rincón M, Davis RJ, Flavell RA. Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation. The Journal of Experimental Medicine. 191: 139-46. PMID 10620612 DOI: 10.1084/Jem.191.1.139  0.506
2000 Chow CW, Davis RJ. Integration of calcium and cyclic AMP signaling pathways by 14-3-3. Molecular and Cellular Biology. 20: 702-12. PMID 10611249 DOI: 10.1128/Mcb.20.2.702-712.2000  0.419
2000 Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ. The JIP group of mitogen-activated protein kinase scaffold proteins. Molecular and Cellular Biology. 19: 7245-54. PMID 10490659 DOI: 10.1128/Mcb.19.10.7245  0.465
2000 Coffey ET, Hongisto V, Dickens M, Davis RJ, Courtney MJ. Dual Roles for c-Jun N-Terminal Kinase in Developmental and Stress Responses in Cerebellar Granule Neurons The Journal of Neuroscience. 20: 7602-7613. DOI: 10.1523/Jneurosci.20-20-07602.2000  0.437
2000 Davis R. Signal Transduction By Stress-Activated Map Kinases Journal of the Peripheral Nervous System. 5: 170-170. DOI: 10.1046/J.1529-8027.2000.005003170.X  0.499
1999 Whitmarsh AJ, Davis RJ. Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches Science's Stke : Signal Transduction Knowledge Environment. 1999. PMID 11865181 DOI: 10.1126/Stke.1999.1.Pe1  0.469
1999 Flavell RA, Li B, Dong C, Lu HT, Yang DD, Enslen H, Tournier C, Whitmarsh A, Wysk M, Conze D, Rincon M, Davis RJ. Molecular basis of T-cell differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 64: 563-71. PMID 11232333 DOI: 10.1101/Sqb.1999.64.563  0.403
1999 Shin TH, Yasuda J, Rocheleau CE, Lin R, Soto M, Bei Y, Davis RJ, Mello CC. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Molecular Cell. 4: 275-80. PMID 10488343 DOI: 10.1016/S1097-2765(00)80375-5  0.488
1999 di Mari JF, Davis R, Safirstein RL. MAPK activation determines renal epithelial cell survival during oxidative injury. The American Journal of Physiology. 277: F195-203. PMID 10444573 DOI: 10.1152/Ajprenal.1999.277.2.F195  0.426
1999 Rocheleau CE, Yasuda J, Shin TH, Lin R, Sawa H, Okano H, Priess JR, Davis RJ, Mello CC. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 97: 717-26. PMID 10380924 DOI: 10.1016/S0092-8674(00)80784-9  0.45
1999 Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22: 667-76. PMID 10230788 DOI: 10.1016/S0896-6273(00)80727-8  0.391
1999 Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, Flavell RA. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. The Embo Journal. 18: 1845-57. PMID 10202148 DOI: 10.1093/Emboj/18.7.1845  0.46
1999 Pandey P, Avraham S, Kumar S, Nakazawa A, Place A, Ghanem L, Rana A, Kumar V, Majumder PK, Avraham H, Davis RJ, Kharbanda S. Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. The Journal of Biological Chemistry. 274: 10140-4. PMID 10187797 DOI: 10.1074/Jbc.274.15.10140  0.478
1999 Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proceedings of the National Academy of Sciences of the United States of America. 96: 3763-8. PMID 10097111 DOI: 10.1073/Pnas.96.7.3763  0.497
1999 Lee RJ, Albanese C, Stenger RJ, Watanabe G, Inghirami G, Haines GK, Webster M, Muller WJ, Brugge JS, Davis RJ, Pestell RG. pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways: A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells Journal of Biological Chemistry. 274: 7341-7350. PMID 10066798 DOI: 10.1074/Jbc.274.11.7341  0.459
1999 Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, Ronai Z. Regulation of JNK signaling by GSTp. The Embo Journal. 18: 1321-34. PMID 10064598 DOI: 10.1093/Emboj/18.5.1321  0.479
1999 Mukherjee PK, DeCoster MA, Campbell FZ, Davis RJ, Bazan NG. Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. The Journal of Biological Chemistry. 274: 6493-8. PMID 10037742 DOI: 10.1074/Jbc.274.10.6493  0.422
1999 Behre G, Whitmarsh AJ, Coghlan MP, Hoang T, Carpenter CL, Zhang DE, Davis RJ, Tenen DG. c-Jun is a JNK-independent coactivator of the PU.1 transcription factor. The Journal of Biological Chemistry. 274: 4939-46. PMID 9988737 DOI: 10.1074/Jbc.274.8.4939  0.367
1999 Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ. The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. Molecular and Cellular Biology. 19: 1569-81. PMID 9891090 DOI: 10.1128/Mcb.19.2.1569  0.491
1999 Li B, Tournier C, Davis RJ, Flavell RA. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. The Embo Journal. 18: 420-32. PMID 9889198 DOI: 10.1093/Emboj/18.2.420  0.322
1999 Rincón M, Whitmarsh A, Yang DD, Weiss L, Dérijard B, Jayaraj P, Davis RJ, Flavell RA. The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. The Journal of Experimental Medicine. 188: 1817-30. PMID 9815259 DOI: 10.1084/Jem.188.10.1817  0.434
1998 Watts BA, Di Mari JF, Davis RJ, Good DW. Hypertonicity activates MAP kinases and inhibits[Formula: see text] absorption via distinct pathways in thick ascending limb. American Journal of Physiology. Renal Physiology. 275: F478-F486. PMID 29586183 DOI: 10.1152/ajprenal.1998.275.4.F478  0.364
1998 Whitmarsh AJ, Davis RJ. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals Trends in Biochemical Sciences. 23: 481-485. PMID 9868371 DOI: 10.1016/S0968-0004(98)01309-7  0.441
1998 Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA. Defective T cell differentiation in the absence of Jnk1. Science (New York, N.Y.). 282: 2092-5. PMID 9851932 DOI: 10.1126/Science.282.5396.2092  0.378
1998 Yang DD, Conze D, Whitmarsh AJ, Barrett T, Davis RJ, Rincón M, Flavell RA. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity. 9: 575-85. PMID 9806643 DOI: 10.1016/S1074-7613(00)80640-8  0.347
1998 Galcheva-Gargova Z, Gangwani L, Konstantinov KN, Mikrut M, Theroux SJ, Enoch T, Davis RJ. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Molecular Biology of the Cell. 9: 2963-71. PMID 9763455 DOI: 10.1091/Mbc.9.10.2963  0.325
1998 Watts BA, Di Mari JF, Davis RJ, Good DW. Hypertonicity activates MAP kinases and inhibits HCO-3 absorption via distinct pathways in thick ascending limb. The American Journal of Physiology. 275: F478-86. PMID 9755119 DOI: 10.1152/Ajprenal.1998.275.4.F478  0.437
1998 Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science (New York, N.Y.). 281: 1671-4. PMID 9733513 DOI: 10.1126/Science.281.5383.1671  0.48
1998 DeCoster MA, Mukherjee PK, Davis RJ, Bazan NG. Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons. Journal of Neuroscience Research. 53: 297-303. PMID 9698157 DOI: 10.1002/(Sici)1097-4547(19980801)53:3<297::Aid-Jnr3>3.0.Co;2-5  0.441
1998 Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 8: 625-34. PMID 9620683 DOI: 10.1016/S1074-7613(00)80567-1  0.36
1998 Han ZS, Enslen H, Hu X, Meng X, Wu IH, Barrett T, Davis RJ, Ip YT. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Molecular and Cellular Biology. 18: 3527-39. PMID 9584193 DOI: 10.1128/Mcb.18.6.3527  0.44
1998 Rincón M, Enslen H, Raingeaud J, Recht M, Zapton T, Su MS, Penix LA, Davis RJ, Flavell RA. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. The Embo Journal. 17: 2817-29. PMID 9582275 DOI: 10.1093/Emboj/17.10.2817  0.453
1998 Jacqué JM, Mann A, Enslen H, Sharova N, Brichacek B, Davis RJ, Stevenson M. Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase. The Embo Journal. 17: 2607-18. PMID 9564043 DOI: 10.1093/Emboj/17.9.2607  0.418
1998 Ip YT, Davis RJ. Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. Current Opinion in Cell Biology. 10: 205-19. PMID 9561845 DOI: 10.1016/S0955-0674(98)80143-9  0.469
1998 Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL. Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases. The Journal of Biological Chemistry. 273: 8922-31. PMID 9535875 DOI: 10.1074/Jbc.273.15.8922  0.492
1998 Yang SH, Whitmarsh AJ, Davis RJ, Sharrocks AD. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. The Embo Journal. 17: 1740-9. PMID 9501095 DOI: 10.1093/Emboj/17.6.1740  0.411
1998 Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Molecular Biology of the Cell. 9: 561-73. PMID 9487126 DOI: 10.1091/Mbc.9.3.561  0.398
1998 Yang SH, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD. The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Molecular and Cellular Biology. 18: 710-20. PMID 9447967 DOI: 10.1128/Mcb.18.2.710  0.466
1998 Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. The Journal of Biological Chemistry. 273: 1741-8. PMID 9430721 DOI: 10.1074/Jbc.273.3.1741  0.421
1998 Gruppuso PA, Awad M, Boylan JM, Enslen H, Davis RJ. Signaling and Cell Cycle Regulation During Liver Development in the Rat• 269 Pediatric Research. 43: 48-48. DOI: 10.1203/00006450-199804001-00290  0.319
1998 Nagata Y, Takahashi N, Davis RJ, Todokoro K. Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation Blood. 92: 1859-1869. DOI: 10.1182/Blood.V92.6.1859.418K37_1859_1869  0.465
1997 Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science (New York, N.Y.). 278: 1638-41. PMID 9374467 DOI: 10.1126/Science.278.5343.1638  0.459
1997 Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389: 865-70. PMID 9349820 DOI: 10.1038/39899  0.413
1997 Sluss HK, Davis RJ. Embryonic morphogenesis signaling pathway mediated by JNK targets the transcriptions factor JUN and the TGF-β homologue decapentaplegic Journal of Cellular Biochemistry. 67: 1-12. PMID 9328834 DOI: 10.1002/(Sici)1097-4644(19971001)67:1<1::Aid-Jcb1>3.0.Co;2-1  0.363
1997 Jho EH, Davis RJ, Malbon CC. c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid. The Journal of Biological Chemistry. 272: 24468-74. PMID 9305908 DOI: 10.1074/jbc.272.39.24468  0.304
1997 Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (New York, N.Y.). 277: 693-6. PMID 9235893 DOI: 10.1126/Science.277.5326.693  0.498
1997 Birnbaum MJ, Van Zundert B, Vaughan PS, Whitmarsh AJ, Van Wijnen AJ, Davis RJ, Stein GS, Stein JL. Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo Journal of Cellular Biochemistry. 66: 175-183. PMID 9213219 DOI: 10.1002/(Sici)1097-4644(19970801)66:2<175::Aid-Jcb5>3.0.Co;2-N  0.48
1997 Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America. 94: 7337-42. PMID 9207092 DOI: 10.1073/Pnas.94.14.7337  0.501
1997 Yang S, Yates PR, Whitmarsh AJ, Davis RJ, Sharrocks AD. The regulation of TCF transcription factors by MAP kinase cascades. Biochemical Society Transactions. 25: 153S. PMID 9191197 DOI: 10.1042/Bst025153S  0.39
1997 Whitmarsh AJ, Yang SH, Su MS, Sharrocks AD, Davis RJ. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. Molecular and Cellular Biology. 17: 2360-71. PMID 9111305 DOI: 10.1128/Mcb.17.5.2360  0.467
1997 Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sanchez I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 94: 3302-7. PMID 9096388 DOI: 10.1073/Pnas.94.7.3302  0.487
1997 Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, Flavell RA. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 3004-9. PMID 9096336 DOI: 10.1073/Pnas.94.7.3004  0.502
1997 Shifrin VI, Davis RJ, Neel BG. Phosphorylation of protein-tyrosine phosphatase PTP-1B on identical sites suggests activation of a common signaling pathway during mitosis and stress response in mammalian cells. The Journal of Biological Chemistry. 272: 2957-62. PMID 9006942 DOI: 10.1074/Jbc.272.5.2957  0.447
1997 Read MA, Whitley MZ, Gupta S, Pierce JW, Best J, Davis RJ, Collins T. Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. The Journal of Biological Chemistry. 272: 2753-61. PMID 9006914 DOI: 10.1074/Jbc.272.5.2753  0.487
1997 Atfi A, Djelloul S, Chastre E, Davis R, Gespach C. Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling Journal of Biological Chemistry. 272: 1429-1432. PMID 8999807 DOI: 10.1074/Jbc.272.3.1429  0.443
1997 Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and Cellular Biology. 17: 24-35. PMID 8972182 DOI: 10.1128/Mcb.17.1.24  0.306
1997 Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. The Journal of Biological Chemistry. 271: 31929-36. PMID 8943238 DOI: 10.1074/Jbc.271.50.31929  0.457
1997 Moxham CM, Tabrizchi A, Davis RJ, Malbon CC. Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo. The Journal of Biological Chemistry. 271: 30765-73. PMID 8940056 DOI: 10.1074/Jbc.271.48.30765  0.416
1996 Sluss HK, Han Z, Barrett T, Goberdhan DC, Wilson C, Davis RJ, Ip YT. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes & Development. 10: 2745-58. PMID 8946915 DOI: 10.1101/Gad.10.21.2745  0.466
1996 Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proceedings of the National Academy of Sciences of the United States of America. 93: 12908-13. PMID 8917518 DOI: 10.1073/pnas.93.23.12908  0.307
1996 Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways Journal of Molecular Medicine. 74: 589-607. PMID 8912180 DOI: 10.1007/S001090050063  0.497
1996 Enslen H, Tokumitsu H, Stork PJ, Davis RJ, Soderling TR. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proceedings of the National Academy of Sciences of the United States of America. 93: 10803-8. PMID 8855261 DOI: 10.1073/Pnas.93.20.10803  0.49
1996 Adler V, Polotskaya A, Kim J, Dolan L, Davis R, Pincus M, Ronai Z. Dose rate and mode of exposure are key factors in JNK activation by UV irradiation Carcinogenesis. 17: 2073-2076. PMID 8824537 DOI: 10.1093/Carcin/17.9.2073  0.377
1996 Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. The Journal of Biological Chemistry. 271: 23775-9. PMID 8798604 DOI: 10.1074/Jbc.271.39.23775  0.466
1996 Lander HM, Jacovina AT, Davis RJ, Tauras JM. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. The Journal of Biological Chemistry. 271: 19705-9. PMID 8702674 DOI: 10.1074/Jbc.271.33.19705  0.504
1996 Galcheva-Gargova Z, Konstantinov KN, Wu IH, Klier FG, Barrett T, Davis RJ. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science (New York, N.Y.). 272: 1797-802. PMID 8650580 DOI: 10.1126/Science.272.5269.1797  0.366
1996 Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Molecular and Cellular Biology. 16: 1247-55. PMID 8622669 DOI: 10.1128/Mcb.16.3.1247  0.481
1996 Shapiro PS, Evans JN, Davis RJ, Posada JA. The seven-transmembrane-spanning receptors for endothelin and thrombin cause proliferation of airway smooth muscle cells and activation of the extracellular regulated kinase and c-Jun NH2-terminal kinase groups of mitogen-activated protein kinases Journal of Biological Chemistry. 271: 5750-5754. PMID 8621441 DOI: 10.1074/Jbc.271.10.5750  0.491
1996 Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ. Selective interaction of JNK protein kinase isoforms with transcription factors. The Embo Journal. 15: 2760-2770. DOI: 10.1002/J.1460-2075.1996.Tb00636.X  0.477
1995 Davis RJ. Transcriptional regulation by MAP kinases Molecular Reproduction and Development. 42: 459-467. PMID 8607977 DOI: 10.1002/Mrd.1080420414  0.479
1995 Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes & Development. 8: 2996-3007. PMID 8001819 DOI: 10.1101/Gad.8.24.2996  0.427
1995 Wartmann M, Campbell D, Subramanian A, Burstein SH, Davis RJ. The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide. Febs Letters. 359: 133-6. PMID 7867785 DOI: 10.1016/0014-5793(95)00027-7  0.458
1995 Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (New York, N.Y.). 267: 682-5. PMID 7839144 DOI: 10.1126/Science.7839144  0.477
1995 Gupta S, Campbell D, Dérijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science (New York, N.Y.). 267: 389-93. PMID 7824938 DOI: 10.1126/Science.7824938  0.467
1995 Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ. Integration of MAP kinase signal transduction pathways at the serum response element Science. 269: 403-407. PMID 7618106 DOI: 10.1126/Science.7618106  0.457
1995 Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. The Journal of Biological Chemistry. 270: 7420-6. PMID 7535770 DOI: 10.1074/Jbc.270.13.7420  0.49
1995 Bagrodia S, Derijard B, Davis RJ, Cerione RA. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen- activated protein kinase activation Journal of Biological Chemistry. 270: 27995-27998. PMID 7499279 DOI: 10.1074/Jbc.270.47.27995  0.465
1995 Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (New York, N.Y.). 270: 1326-31. PMID 7481820 DOI: 10.1126/Science.270.5240.1326  0.479
1994 Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76: 1025-37. PMID 8137421 DOI: 10.1016/0092-8674(94)90380-8  0.465
1994 Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature. 367: 651-4. PMID 8107850 DOI: 10.1038/367651A0  0.47
1994 Galcheva-Gargova Z, Dérijard B, Wu IH, Davis RJ. An osmosensing signal transduction pathway in mammalian cells. Science (New York, N.Y.). 265: 806-8. PMID 8047888 DOI: 10.1126/Science.8047888  0.491
1994 Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science. 266: 1719-1723. PMID 7992057 DOI: 10.1126/Science.7992057  0.464
1994 Sluss HK, Barrett T, Dérijard B, Davis RJ. Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Molecular and Cellular Biology. 14: 8376-84. PMID 7969172 DOI: 10.1128/Mcb.14.12.8376  0.502
1994 Gupta S, Davis RJ. MAP kinase binds to the NH2-terminal activation domain of c-Myc Febs Letters. 353: 281-285. PMID 7957875 DOI: 10.1016/0014-5793(94)01052-8  0.406
1994 Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases Molecular and Cellular Biology. 14: 6683-6688. PMID 7935387 DOI: 10.1128/mcb.14.10.6683-6688.1994  0.454
1994 Davis RJ. MAPKs: new JNK expands the group Trends in Biochemical Sciences. 19: 470-473. PMID 7855889 DOI: 10.1016/0968-0004(94)90132-5  0.485
1994 Mansour SJ, Resing KA, Candi JM, Hermann AS, Gloor JW, Herskind KR, Wartmann M, Davis RJ, Ahn NG. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. Journal of Biochemistry. 116: 304-14. PMID 7822248 DOI: 10.1093/Oxfordjournals.Jbchem.A124524  0.466
1993 Gonzalez FA, Seth A, Raden DL, Bowman DS, Fay FS, Davis RJ. Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. The Journal of Cell Biology. 122: 1089-101. PMID 8394846 DOI: 10.1083/Jcb.122.5.1089  0.469
1993 Gupta S, Seth A, Davis RJ. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proceedings of the National Academy of Sciences of the United States of America. 90: 3216-20. PMID 8386367 DOI: 10.1073/Pnas.90.8.3216  0.358
1993 Lin LL, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. cPLA2 is phosphorylated and activated by MAP kinase Cell. 72: 269-278. PMID 8381049 DOI: 10.1016/0092-8674(93)90666-E  0.444
1993 Seth A, Gupta S, Davis RJ. Cell cycle regulation of the c-Myc transcriptional activation domain. Molecular and Cellular Biology. 13: 4125-36. PMID 8321217 DOI: 10.1128/Mcb.13.7.4125  0.319
1993 Theroux SJ, Stanley K, Campbell DA, Davis RJ. Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation. Molecular Endocrinology (Baltimore, Md.). 6: 1849-57. PMID 1480174 DOI: 10.1210/Mend.6.11.1480174  0.384
1992 Gonzalez FA, Raden DL, Rigby MR, Davis RJ. Heterogeneous expression of four MAP kinase isoforms in human tissues Febs Letters. 304: 170-178. PMID 1319925 DOI: 10.1016/0014-5793(92)80612-K  0.447
1992 Nair N, Davis RJ, Robinson HL. Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: Correlation of oncogenic activation with altered kinetics Molecular and Cellular Biology. 12: 2010-2016. PMID 1314948 DOI: 10.1128/Mcb.12.5.2010  0.429
1990 Northwood IC, Davis RJ. Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity Proceedings of the National Academy of Sciences of the United States of America. 87: 6107-6111. PMID 2166944 DOI: 10.1073/Pnas.87.16.6107  0.472
1987 Davis RJ, Czech MP. Regulatory control of the epidermal growth factor receptor tyrosine kinase Hamatologie Und Bluttransfusion. 31: 228-232. PMID 2832268 DOI: 10.1007/978-3-642-72624-8_47  0.614
1986 Corvera S, Davis RJ, Roach PJ, DePaoli-Roach A, Czech MP. Mechanism of receptor kinase action on membrane protein recycling Annals of the New York Academy of Sciences. 488: 419-429. PMID 3034121 DOI: 10.1111/J.1749-6632.1986.Tb54421.X  0.707
1986 Ignotz RA, Kelly B, Davis RJ, Massagué J. Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 6307-11. PMID 3018723 DOI: 10.1073/Pnas.83.17.6307  0.493
1986 Czech MP, Yu KT, Lewis RE, Davis RJ, Mottola C, MacDonald RG, Necessary PC, Corvera S. Insulin receptor kinase and its mode of signaling membrane components. Diabetes/Metabolism Reviews. 1: 33-58. PMID 3013541 DOI: 10.1002/Dmr.5610010104  0.774
1986 Davis RJ, Czech MP. Inhibition of the apparent affinity of the epidermal growth factor receptor caused by phorbol diesters correlates with phosphorylation of threonine-654 but not other sites on the receptor Biochemical Journal. 233: 435-441. PMID 3006669 DOI: 10.1042/Bj2330435  0.547
1986 Davis R, Czech M. Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor. The Embo Journal. 5: 653-658. DOI: 10.1002/J.1460-2075.1986.Tb04263.X  0.524
1985 Davis RJ, Czech MP. Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654 Proceedings of the National Academy of Sciences of the United States of America. 82: 4080-4084. PMID 2987962 DOI: 10.1073/Pnas.82.12.4080  0.584
1985 Davis RJ, Czech MP. Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654 Proceedings of the National Academy of Sciences of the United States of America. 82: 1974-1978. PMID 2984676 DOI: 10.1073/Pnas.82.7.1974  0.54
1985 Davis R, Like B, Massagué J. Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter. Journal of Cellular Biochemistry. 27: 23-30. PMID 2984222 DOI: 10.1002/Jcb.240270104  0.524
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