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Andrew D. Mesecar - Publications

Affiliations: 
Molecular Biosciences Purdue University, West Lafayette, IN, United States 
Area:
molecular mechanisms and function of therapeutic enzymes and proteins
Website:
http://www.chem.purdue.edu/people/faculty/faculty.asp?itemID=91
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96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ghosh AK, Shahabi D, Imhoff MEC, Kovela S, Sharma A, Hattori SI, Higashi-Kuwata N, Mitsuya H, Mesecar AD. SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads. Bioorganic & Medicinal Chemistry Letters. 96: 129489. PMID 37770002 DOI: 10.1016/j.bmcl.2023.129489  0.314
2023 Bose S, Steussy CN, López-Pérez D, Schmidt T, Kulathunga SC, Seleem MN, Lipton M, Mesecar AD, Rodwell VW, Stauffacher CV. Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor. Communications Biology. 6: 360. PMID 37012403 DOI: 10.1038/s42003-023-04639-y  0.336
2021 Ghosh AK, Shahabi D, Yadav M, Kovela S, Anson BJ, Lendy EK, Bonham C, Sirohi D, Brito-Sierra CA, Hattori SI, Kuhn R, Mitsuya H, Mesecar AD. Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26. PMID 34641337 DOI: 10.3390/molecules26195782  0.339
2021 Ghosh AK, Raghavaiah J, Shahabi D, Yadav M, Anson BJ, Lendy EK, Hattori SI, Higashi-Kuwata N, Mitsuya H, Mesecar AD. Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of Medicinal Chemistry. PMID 34528437 DOI: 10.1021/acs.jmedchem.1c01214  0.336
2019 Yen YC, Kammeyer A, Jensen KC, Tirlangi J, Ghosh AK, Mesecar AD. Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors. Biochemistry. PMID 31549827 DOI: 10.1021/Acs.Biochem.9B00714  0.304
2016 Hjortland NM, Mesecar AD. Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme. Archives of Biochemistry and Biophysics. 612: 35-45. PMID 27756680 DOI: 10.1016/J.Abb.2016.10.008  0.332
2015 St John SE, Tomar S, Stauffer SR, Mesecar AD. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS). Bioorganic & Medicinal Chemistry. 23: 6036-48. PMID 26190463 DOI: 10.1016/j.bmc.2015.06.039  0.303
2015 Báez-Santos YM, St John SE, Mesecar AD. The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Research. 115: 21-38. PMID 25554382 DOI: 10.1016/J.Antiviral.2014.12.015  0.336
2014 Zhai X, Go MK, O'Donoghue AC, Amyes TL, Pegan SD, Wang Y, Loria JP, Mesecar AD, Richard JP. Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501. PMID 24825099 DOI: 10.1021/Bi500458T  0.586
2014 Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD. X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. Journal of Medicinal Chemistry. 57: 2393-412. PMID 24568342 DOI: 10.1021/Jm401712T  0.313
2013 St John SE, Jensen KC, Kang S, Chen Y, Calamini B, Mesecar AD, Lipton MA. Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorganic & Medicinal Chemistry. 21: 6022-37. PMID 23953689 DOI: 10.1016/J.Bmc.2013.07.037  0.363
2012 Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1. Analytical Biochemistry. 421: 108-14. PMID 22074792 DOI: 10.1016/J.Ab.2011.10.028  0.366
2011 Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Molecular Nutrition & Food Research. 55: 1249-65. PMID 21714126 DOI: 10.1002/Mnfr.201100122  0.717
2011 Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Science : a Publication of the Protein Society. 20: 1182-95. PMID 21538647 DOI: 10.1002/Pro.647  0.361
2011 Hu C, Eggler AL, Mesecar AD, van Breemen RB. Modification of keap1 cysteine residues by sulforaphane. Chemical Research in Toxicology. 24: 515-21. PMID 21391649 DOI: 10.1021/Tx100389R  0.317
2011 Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, et al. Bioactive compounds from the fern Lepisorus contortus. Journal of Natural Products. 74: 129-36. PMID 21261296 DOI: 10.1021/Np100373F  0.733
2011 Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB, et al. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Analytical Chemistry. 83: 1048-52. PMID 21192729 DOI: 10.1021/Ac1028424  0.744
2011 Choi Y, Jermihov K, Nam S, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen S, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB. Correction to Screening Natural Products for Inhibitors of Quinone Reductase-2 Using Ultrafiltration LC–MS Analytical Chemistry. 83: 4325-4325. DOI: 10.1021/Ac2010197  0.724
2010 Conda-Sheridan M, Marler L, Park EJ, Kondratyuk TP, Jermihov K, Mesecar AD, Pezzuto JM, Asolkar RN, Fenical W, Cushman M. Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. Journal of Medicinal Chemistry. 53: 8688-99. PMID 21105712 DOI: 10.1021/Jm1011066  0.736
2010 Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto JM, Mesecar AD, Cushman M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorganic & Medicinal Chemistry. 18: 5352-66. PMID 20558073 DOI: 10.1016/J.Bmc.2010.05.042  0.413
2010 Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. Journal of Medicinal Chemistry. 53: 4968-79. PMID 20527968 DOI: 10.1021/Jm1004489  0.45
2010 Burks EA, Fleming CD, Mesecar AD, Whitman CP, Pegan SD. Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily . Biochemistry. 49: 5016-27. PMID 20465238 DOI: 10.1021/Bi100502Z  0.361
2010 Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. The Biochemical Journal. 429: 273-82. PMID 20450491 DOI: 10.1042/Bj20091857  0.398
2010 Clementz MA, Chen Z, Banach BS, Wang Y, Sun L, Ratia K, Baez-Santos YM, Wang J, Takayama J, Ghosh AK, Li K, Mesecar AD, Baker SC. Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. Journal of Virology. 84: 4619-29. PMID 20181693 DOI: 10.1128/Jvi.02406-09  0.343
2010 Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, Van Breemen RB, Pezzuto JM, Fong HH, et al. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 71: 641-7. PMID 20100622 DOI: 10.1016/J.Phytochem.2010.01.002  0.401
2010 Marler LE, Cushman M, Sun B, Mesecar AD, Jermihov K, Breemen RBv, Pezzuto JM. Abstract A68: Aromatase inhibition and chemopreventive potential of novel resveratrol derivatives Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A68  0.392
2010 Eggler AL, Small E, Hannink M, Mesecar AD. Abstract A58: Cul3‐mediated Nrf2 ubiquitination and ARE activation are dependent on the partial molar volume at position 151 of Keap1 Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A58  0.341
2009 Zhang H, Rothwangl K, Mesecar AD, Sabahi A, Rong L, Fong HH. Lamiridosins, hepatitis C virus entry inhibitors from Lamium album. Journal of Natural Products. 72: 2158-62. PMID 19904996 DOI: 10.1021/Np900549E  0.3
2009 Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/J.Bmc.2009.08.061  0.363
2009 Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. Journal of Medicinal Chemistry. 52: 5228-40. PMID 19645480 DOI: 10.1021/Jm900611T  0.45
2009 Hawwa R, Larsen SD, Ratia K, Mesecar AD. Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans. Journal of Molecular Biology. 393: 36-57. PMID 19631223 DOI: 10.1016/J.Jmb.2009.06.083  0.401
2009 Hawwa R, Aikens J, Turner RJ, Santarsiero BD, Mesecar AD. Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus. Archives of Biochemistry and Biophysics. 488: 109-20. PMID 19615330 DOI: 10.1016/J.Abb.2009.06.005  0.393
2009 Eggler AL, Small E, Hannink M, Mesecar AD. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. The Biochemical Journal. 422: 171-80. PMID 19489739 DOI: 10.1042/Bj20090471  0.346
2009 Kim KH, Gaisina I, Gallier F, Holzle D, Blond SY, Mesecar A, Kozikowski AP. Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl) maleimides as GSK-3β inhibitors Journal of Molecular Modeling. 15: 1463-1479. PMID 19440740 DOI: 10.1007/S00894-009-0498-X  0.328
2009 Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of Medicinal Chemistry. 52: 1873-84. PMID 19265439 DOI: 10.1021/Jm801335Z  0.303
2009 Pegan SD, Rukseree K, Franzblau SG, Mesecar AD. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Journal of Molecular Biology. 386: 1038-53. PMID 19167403 DOI: 10.1016/J.Jmb.2009.01.003  0.347
2009 Sershon VC, Santarsiero BD, Mesecar AD. Kinetic and X-ray structural evidence for negative cooperativity in substrate binding to nicotinate mononucleotide adenylyltransferase (NMAT) from Bacillus anthracis. Journal of Molecular Biology. 385: 867-88. PMID 18977360 DOI: 10.1016/J.Jmb.2008.10.037  0.341
2008 Pegan SD, Serrano H, Whitman CP, Mesecar AD. Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallographica. Section D, Biological Crystallography. 64: 1277-82. PMID 19018104 DOI: 10.1107/S0907444908034707  0.384
2008 Tian Y, Suk DH, Cai F, Crich D, Mesecar AD. Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediate. Biochemistry. 47: 12434-47. PMID 18973344 DOI: 10.1021/Bi801311D  0.394
2008 Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proceedings of the National Academy of Sciences of the United States of America. 105: 16119-24. PMID 18852458 DOI: 10.1073/Pnas.0805240105  0.447
2008 Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5684-8. PMID 18796354 DOI: 10.1016/J.Bmcl.2008.08.082  0.373
2008 Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase. Chemmedchem. 3: 1250-68. PMID 18663709 DOI: 10.1002/Cmdc.200800047  0.386
2008 Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/J.Bmcl.2008.05.004  0.372
2008 Eggler AL, Gay KA, Mesecar AD. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Molecular Nutrition & Food Research. 52: S84-94. PMID 18435489 DOI: 10.1002/Mnfr.200700249  0.365
2008 Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. The Biochemical Journal. 413: 81-91. PMID 18254726 DOI: 10.1042/Bj20071373  0.403
2008 Grum-Tokars V, Ratia K, Begaye A, Baker SC, Mesecar AD. Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery. Virus Research. 133: 63-73. PMID 17397958 DOI: 10.1016/J.Virusres.2007.02.015  0.397
2008 Park S, Bagriantsev S, Callan LA, Pegan SD, Mesecar AD, Liebman SW. P2-350: Yeast cell-based genetic and chemical screens for inhibitors of Aβ42 oligomerization Alzheimer's & Dementia. 4: T475-T475. DOI: 10.1016/J.Jalz.2008.05.1427  0.301
2007 Ghosh AK, Xi K, Johnson ME, Baker SC, Mesecar AD. Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy. Annual Reports in Medicinal Chemistry. 41: 183-196. PMID 19649165 DOI: 10.1016/S0065-7743(06)41011-3  0.408
2007 Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of alkylation of human Keap1 by natural chemoprevention agents. Journal of the American Society For Mass Spectrometry. 18: 2226-32. PMID 17980616 DOI: 10.1016/J.Jasms.2007.09.015  0.316
2007 Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chemical Research in Toxicology. 20: 1878-84. PMID 17935299 DOI: 10.1021/Tx700217C  0.312
2007 Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5876-80. PMID 17855091 DOI: 10.1016/J.Bmcl.2007.08.031  0.412
2007 May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD. Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. Journal of Molecular Biology. 371: 1219-37. PMID 17610893 DOI: 10.1016/J.Jmb.2007.05.093  0.372
2007 Chen Z, Wang Y, Ratia K, Mesecar AD, Wilkinson KD, Baker SC. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. Journal of Virology. 81: 6007-18. PMID 17392370 DOI: 10.1128/Jvi.02747-06  0.356
2006 Cuendet M, Mesecar AD, DeWitt DL, Pezzuto JM. An ELISA method to measure inhibition of the COX enzymes. Nature Protocols. 1: 1915-21. PMID 17487176 DOI: 10.1038/Nprot.2006.308  0.328
2006 Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochemical Analysis : Pca. 17: 398-405. PMID 17144247 DOI: 10.1002/Pca.937  0.36
2006 Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Deubiquitinating activity of the SARS-CoV papain-like protease. Advances in Experimental Medicine and Biology. 581: 37-41. PMID 17037501 DOI: 10.1007/978-0-387-33012-9_5  0.345
2006 Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proceedings of the National Academy of Sciences of the United States of America. 103: 5717-22. PMID 16581910 DOI: 10.1073/Pnas.0510851103  0.364
2006 Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Santarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH. Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Medica. 72: 255-60. PMID 16534731 DOI: 10.1055/S-2005-873171  0.416
2006 Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH. Miliusanes, a class of cytotoxic agents from Miliusa sinensis. Journal of Medicinal Chemistry. 49: 693-708. PMID 16420055 DOI: 10.1021/Jm0509492  0.391
2006 Su BN, Chai H, Mi Q, Riswan S, Kardono LB, Afriastini JJ, Santarsiero BD, Mesecar AD, Farnsworth NR, Cordell GA, Swanson SM, Kinghorn AD. Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia. Bioorganic & Medicinal Chemistry. 14: 960-72. PMID 16216518 DOI: 10.1016/J.Bmc.2005.09.012  0.363
2005 Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. Journal of Virology. 79: 15189-98. PMID 16306590 DOI: 10.1128/Jvi.79.24.15189-15198.2005  0.355
2005 Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. Journal of Medicinal Chemistry. 48: 6767-71. PMID 16250632 DOI: 10.1021/Jm050548M  0.338
2005 Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Analytical Chemistry. 77: 6407-14. PMID 16194107 DOI: 10.1021/Ac050892R  0.419
2005 Grimsley JK, Calamini B, Wild JR, Mesecar AD. Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site. Archives of Biochemistry and Biophysics. 442: 169-79. PMID 16188223 DOI: 10.1016/J.Abb.2005.08.012  0.39
2005 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chemical Research in Toxicology. 18: 1296-305. PMID 16097803 DOI: 10.1021/Tx050058X  0.398
2005 Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences of the United States of America. 102: 10070-5. PMID 16006525 DOI: 10.1073/Pnas.0502402102  0.351
2005 Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry. 44: 9417-29. PMID 15996096 DOI: 10.1107/S010876730509210X  0.338
2005 Ratia K, Santarsiero B, Xi K, Jukneliene D, Harcourt B, Baker S, Ghosh A, Mesecar A. Kinetic and crystallographic analyses of SARS coronavirus 3CLpro inhibitors Acta Crystallographica Section a Foundations of Crystallography. 61: c236-c236. DOI: 10.1107/S0108767305089944  0.354
2005 Calamini B, Santarsiero B, Ratia K, Malkowski M, Pezzuto J, Mesecar A. Structural basis for potent inhibition of COX by resveratrol - a natural product in wine Acta Crystallographica Section a Foundations of Crystallography. 61: c244-c244. DOI: 10.1107/S0108767305089610  0.369
2005 Larsen S, Ratia K, Santarsiero BD, Mesecar AD. Structural studies of a novel phosphotriesterase capable of degrading soman Acta Crystallographica Section a Foundations of Crystallography. 61: c255-c255. DOI: 10.1107/S0108767305089117  0.311
2004 Rumthao S, Lee O, Sheng Q, Fu W, Mulhearn DC, Crich D, Mesecar AD, Johnson ME. Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa. Bioorganic & Medicinal Chemistry Letters. 14: 5165-70. PMID 15380220 DOI: 10.1016/J.Bmcl.2004.07.054  0.325
2004 Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, et al. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. The Journal of Organic Chemistry. 69: 3350-8. PMID 15132542 DOI: 10.1021/Jo040120F  0.333
2004 Li Y, Yao J, Chang M, Nikolic D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chemical Research in Toxicology. 17: 512-20. PMID 15089093 DOI: 10.1021/Tx0342464  0.322
2004 Graham JG, Zhang H, Pendland SL, Santarsiero BD, Mesecar AD, Cabieses F, Farnsworth NR. Antimycobacterial Naphthopyrones from Senna obliqua. Journal of Natural Products. 67: 225-7. PMID 14987063 DOI: 10.1021/Np030348I  0.37
2003 Su BN, Kang YH, Pinos RE, Santarsiero BD, Mesecar AD, Soejarto DD, Fong HH, Pezzuto JM, Kinghorn AD. Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis. Phytochemistry. 64: 293-302. PMID 12946428 DOI: 10.1016/S0031-9422(03)00268-1  0.332
2003 Rao KV, Santarsiero BD, Mesecar AD, Schinazi RF, Tekwani BL, Hamann MT. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. Journal of Natural Products. 66: 823-8. PMID 12828469 DOI: 10.1021/Np020592U  0.33
2003 Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). Journal of Natural Products. 66: 583-7. PMID 12762787 DOI: 10.1021/Np020522N  0.386
2003 Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, Van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chemical Research in Toxicology. 16: 668-75. PMID 12755597 DOI: 10.1021/Tx0340549  0.328
2003 Su BN, Park EJ, Nikolic D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity. The Journal of Organic Chemistry. 68: 2350-61. PMID 12636402 DOI: 10.1021/Jo020542U  0.413
2003 Park S, Hayes BL, Marankan F, Mulhearn DC, Wanna L, Mesecar AD, Santarsiero BD, Johnson ME, Venton DL. Regioselective covalent modification of hemoglobin in search of antisickling agents. Journal of Medicinal Chemistry. 46: 936-53. PMID 12620071 DOI: 10.1021/Jm020361K  0.363
2002 Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase. Journal of Agricultural and Food Chemistry. 50: 6330-4. PMID 12381112 DOI: 10.1021/Jf0206670  0.369
2002 Su BN, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Fong HH, Pezzuto JM, Kinghorn AD. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. Journal of Natural Products. 65: 1278-82. PMID 12350147 DOI: 10.1021/Np0202475  0.349
2002 Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. Bioactive constituents of the seeds of Brucea javanica. Planta Medica. 68: 730-3. PMID 12221597 DOI: 10.1055/S-2002-33798  0.353
2002 Chen SN, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. Journal of Natural Products. 65: 601-5. PMID 11975513 DOI: 10.1021/Np010494T  0.337
2002 Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME. An oxyanion-Hole selective serine protease inhibitor in complex with trypsin Bioorganic and Medicinal Chemistry. 10: 41-46. PMID 11738605 DOI: 10.1016/S0968-0896(01)00259-0  0.32
2002 Li SH, Zhang HJ, Qiu SX, Niu XM, Santarsiero BD, Mesecar AD, Fong HHS, Farnsworth NR, Sun HD. Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus Tetrahedron Letters. 43: 5131-5134. DOI: 10.1016/S0040-4039(02)00981-4  0.321
2002 Su BN, Misico R, Jung Park E, Santarsiero BD, Mesecar AD, Fong HHS, Pezzuto JM, Douglas Kinghorn A. Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica Tetrahedron. 58: 3453-3466. DOI: 10.1016/S0040-4020(02)00277-6  0.345
2000 Bond CJ, Jurica MS, Mesecar A, Stoddard BL. Determinants of allosteric activation of yeast pyruvate kinase and identification of novel effectors using computational screening Biochemistry. 39: 15333-15343. PMID 11112519 DOI: 10.1021/Bi001443I  0.316
2000 Mesecar AD, Koshland DE. Sites of binding and orientation in a four-location model for protein stereospecificity. Iubmb Life. 49: 457-66. PMID 10902579 DOI: 10.1080/152165400410326  0.484
2000 Mesecar AD, Koshland DE. A new model for protein stereospecificity. Nature. 403: 614-5. PMID 10688187 DOI: 10.1038/35047170  0.413
1999 Bollenbach TJ, Mesecar AD, Nowak T. Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis. Biochemistry. 38: 9137-45. PMID 10413488 DOI: 10.1021/Bi990690N  0.577
1999 Stoddard BL, Bolduc J, Dyer D, Galburt E, Cohen B, Brubaker M, Mesecar A, Koshland DE, Scott B, Flick K, Jurica M. Time-resolved intermediate trapping and X-ray crystallographic studies of enzyme mechanism: Isocitrate dehydrogenase and nuclease catalysts Biochemical Society Transactions. 27: A2-A2. DOI: 10.1042/Bst027A002B  0.606
1998 Stoddard BL, Cohen BE, Brubaker M, Mesecar AD, Koshland DE. Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs. Nature Structural Biology. 5: 891-7. PMID 9783749 DOI: 10.1038/2331  0.653
1998 Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate Structure. 6: 195-210. PMID 9519410 DOI: 10.1016/S0969-2126(98)00021-5  0.659
1997 Mesecar AD, Stoddard BL, Koshland DE. Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science (New York, N.Y.). 277: 202-6. PMID 9211842 DOI: 10.1126/Science.277.5323.202  0.479
1997 Mesecar AD, Nowak T. Metal-ion-mediated allosteric triggering of yeast pyruvate kinase. 1. A multidimensional kinetic linked-function analysis Biochemistry. 36: 6792-6802. PMID 9184162 DOI: 10.1021/Bi962869T  0.614
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