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Gucan Dai, Ph.D. - Publications

Affiliations: 
Biochemistry and Molecular Biology Saint Louis University School of Medicine, St. Louis, MO, United States 
Area:
ion channel biophysics
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Handlin LJ, Dai G. Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization. Nature Communications. 14: 6595. PMID 37852983 DOI: 10.1038/s41467-023-42363-7  0.503
2023 Dai G. Signaling by Ion Channels: Pathways, Dynamics and Channelopathies. Missouri Medicine. 120: 367-373. PMID 37841571  0.479
2022 Jensen JB, Falkenburger BH, Dickson EJ, de la Cruz L, Dai G, Myeong J, Jung SR, Kruse M, Vivas O, Suh BC, Hille B. Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells. The Journal of General Physiology. 154. PMID 35583815 DOI: 10.1085/jgp.202113074  0.724
2022 Dai G. Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1. The Journal of General Physiology. 154. PMID 35201266 DOI: 10.1085/jgp.202112888  0.484
2022 Dai G. Symmetry breaking in photoreceptor cyclic nucleotide-gated channels. Nature Structural & Molecular Biology. PMID 35027742 DOI: 10.1038/s41594-021-00711-5  0.581
2021 Dai G, Aman TK, DiMaio F, Zagotta WN. Electromechanical coupling mechanism for activation and inactivation of an HCN channel. Nature Communications. 12: 2802. PMID 33990563 DOI: 10.1038/s41467-021-23062-7  0.823
2020 Dai G, Zagotta WN. Structural Determinants of the Hyperpolarization-Dependent Gating of HCN Channels Biophysical Journal. 118: 331a-332a. DOI: 10.1016/J.Bpj.2019.11.1853  0.813
2019 Dai G, Aman TK, Dimaio F, Zagotta WN. The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization. Nat Struct Mol Biol.. PMID 31285608 DOI: 10.1038/S41594-019-0259-1  0.806
2018 Dai G, James ZM, Zagotta WN. Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels. The Journal of General Physiology. PMID 29567795 DOI: 10.1085/Jgp.201711989  0.804
2018 Hilgemann DW, Dai G, Collins A, Lariccia V, Magi S, Deisl C, Fine M. Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis. J Gen Physiol.. PMID 29326133 DOI: 10.1085/jgp.201711875  0.401
2018 Hilgemann DW, Dai G, Collins A, Larricia V, Magi S, Deisl C, Fine M. Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis. The Journal of General Physiology. PMID 29326133 DOI: 10.1085/Jgp.201711875  0.497
2018 Dai G, James ZM, Zagotta WN. Dynamic Rearrangement of the Intrinsic Ligand Regulates Gating of KCNH Potassium Channels Biophysical Journal. 114: 292a. DOI: 10.1016/J.Bpj.2017.11.1669  0.804
2017 Zagotta WN, Dai G. Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels. Elife. 6. PMID 28443815 DOI: 10.7554/Elife.26355  0.819
2017 Dai G, Zagotta WN. Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels. Elife. PMID 28443815 DOI: 10.7554/eLife.26355  0.588
2017 Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B. Fatty-acyl chain profiles of cellular phosphoinositides. Biochimica Et Biophysica Acta. PMID 28189644 DOI: 10.1016/J.Bbalip.2017.02.002  0.513
2017 Dai G, Zagotta WN. Author response: Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels Elife. DOI: 10.7554/Elife.26355.015  0.794
2017 Dai G, Zagotta W. Molecular Mechanisms of the Voltage-Dependent Potentiation of KCNH Potassium Channels Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.248  0.829
2016 Dai G, Yu H, Kruse M, Traynor-Kaplan A, Hille B. Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27217553 DOI: 10.1073/Pnas.1606348113  0.625
2015 Wu S, Song X, Liu B, Dai G, Liu J, Zhang K, Qin S, Hua D, Gao F, Liu L. Mobile multi-wavelength polarization Raman lidar for water vapor, cloud and aerosol measurement. Optics Express. 23: 33870-92. PMID 26832047  0.341
2014 Lee VK, Kim DY, Ngo H, Lee Y, Seo L, Yoo SS, Vincent PA, Dai G. Creating perfused functional vascular channels using 3D bio-printing technology. Biomaterials. 35: 8092-102. PMID 24965886 DOI: 10.1016/J.Biomaterials.2014.05.083  0.354
2014 Dai G, Sherpa T, Varnum MD. Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides. The Journal of Biological Chemistry. 289: 13680-90. PMID 24675082 DOI: 10.1074/Jbc.M114.562272  0.832
2013 Shao PP, Ye F, Chakravarty PK, Herrington JB, Dai G, Bugianesi RM, Haedo RJ, Swensen AM, Warren VA, Smith MM, Garcia ML, McManus OB, Lyons KA, Li X, Green M, et al. Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide. Acs Medicinal Chemistry Letters. 4: 1064-8. PMID 24900606 DOI: 10.1021/ml4002612  0.472
2013 Dai G, Varnum MD. CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions. American Journal of Physiology. Cell Physiology. 305: C147-59. PMID 23552282 DOI: 10.1152/Ajpcell.00037.2013  0.823
2013 Dai G, Peng C, Liu C, Varnum MD. Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides. The Journal of General Physiology. 141: 413-30. PMID 23530136 DOI: 10.1085/Jgp.201210944  0.817
2013 Dai G, Peng C, Rich E, Varnum MD. Distinct Contributions of CNGA3 and CNGB3 Subunits to Ligand-Specific Activation of Cone CNG Channels Biophysical Journal. 104: 278a. DOI: 10.1016/J.Bpj.2012.11.1559  0.827
2012 Dai G, Sherpa T, Rich E, Mills D, Peng C, Varnum MD. Alternative Splicing for CNGA3 Controls Channel Sensitivity to Regulation by Phosphoinositides Biophysical Journal. 102: 131a. DOI: 10.1016/J.Bpj.2011.11.728  0.832
2010 Dai G, Rich E, Brown L, Varnum M. Subunit-Specific Regulation of Photoreceptor CNG Channels by Phosphoinositides Biophysical Journal. 98: 707a. DOI: 10.1016/J.Bpj.2009.12.3877  0.819
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