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Xin Linghu, Ph.D. - Publications

Affiliations: 
Chemistry Genentech, Inc., San Francisco, CA, United States 
Area:
organic chemistry
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Molinaro C, Kelly S, Tang A, Iding H, Stocker P, Linghu X, Gosselin F. Asymmetric Synthesis of -Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated -Alkyl Amino Esters. Organic Letters. PMID 38051775 DOI: 10.1021/acs.orglett.3c03784  0.312
2019 Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters. PMID 31668077 DOI: 10.1021/Acs.Orglett.9B03481  0.567
2018 Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F. Macrolactamization Approaches to Arylomycin Antibiotics Core. Organic Letters. PMID 30565949 DOI: 10.1021/Acs.Orglett.8B03603  0.397
2018 Chen Z, Hong AY, Linghu X. Construction of Polycyclic β-Ketoesters using a Homoconjugate Addition / Decarboxylative Dieckmann Annulation Strategy. The Journal of Organic Chemistry. PMID 29766724 DOI: 10.1021/Acs.Joc.8B00754  0.469
2018 Linghu X, Segraves NL, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig SG, Gosselin F. Cover Feature: Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate (Chem. Eur. J. 12/2018) Chemistry: a European Journal. 24: 2792-2792. DOI: 10.1002/Chem.201706013  0.325
2017 Linghu X, Segraves N, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig S, Gosselin F. Highly Efficient Synthesis of a Staphylococcus aureus-targeting Payload, Enabling the First Antibody-Antibiotic Conjugate. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29164727 DOI: 10.1002/Chem.201705392  0.4
2017 Linghu X, Wong N, Jost V, Fantasia S, Sowell CG, Gosselin F. Kumada–Corriu Heteroaryl Cross-Coupling for Synthesis of a Pharmaceutical Intermediate: Comparison of Batch Versus Continuous Reaction Modes Organic Process Research & Development. 21: 1320-1325. DOI: 10.1021/Acs.Oprd.7B00185  0.601
2017 Linghu X, Wong N, Iding H, Jost V, Zhang H, Koenig SG, Sowell CG, Gosselin F. Development of a Practical Synthesis of ERK Inhibitor GDC-0994 Organic Process Research & Development. 21: 387-398. DOI: 10.1021/Acs.Oprd.7B00006  0.488
2017 Yang S, Linghu X, Smith E, Pan J, Sprague V, Su J. Synthesis of bicyclic β-lactamase inhibitor relabactam derivatives from a relabactam intermediate Tetrahedron Letters. 58: 2838-2841. DOI: 10.1016/J.Tetlet.2017.06.018  0.45
2016 Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119. PMID 27874860 DOI: 10.1038/Nchem.2635  0.306
2014 Wong B, Linghu X, Crawford JJ, Drobnick J, Lee W, Zhang H. A chemoselective Reformatsky-Negishi approach to α-haloaryl esters Tetrahedron. 70: 1508-1515. DOI: 10.1016/J.Tet.2013.12.053  0.46
2013 McLaughlin M, Belyk K, Chen CY, Linghu X, Pan J, Qian G, Reamer RA, Xu Y. Practical asymmetric synthesis of a chiral piperazinone derivative Organic Process Research and Development. 17: 1052-1060. DOI: 10.1021/Op400150W  0.442
2012 Boyce GR, Greszler SN, Johnson JS, Linghu X, Malinowski JT, Nicewicz DA, Satterfield AD, Schmitt DC, Steward KM. Silyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling. The Journal of Organic Chemistry. 77: 4503-15. PMID 22414181 DOI: 10.1021/Jo300184H  0.493
2012 Goodyear A, Linghu X, Bishop B, Chen C, Cleator E, McLaughlin M, Sheen FJ, Stewart GW, Xu Y, Yin. J. Process development and large-scale synthesis of MK-6186, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV Organic Process Research and Development. 16: 605-611. DOI: 10.1021/Op200334X  0.354
2012 Linghu X, McLaughlin M, Chen CY, Reamer RA, Dimichele L, Davies IW. Synthesis of functionalized 3-chloro-1-naphthols via Friedel-Crafts acylation of vinyl chlorides Tetrahedron Letters. 53: 1550-1552. DOI: 10.1016/J.Tetlet.2012.01.011  0.59
2008 Linghu X, Kennedy-Smith JJ, Toste FD. Synthesis of (+)-Fawcettimine Synfacts. 2008: 124-124. DOI: 10.1055/S-2007-992500  0.414
2007 Linghu X, Kennedy-Smith JJ, Toste FD. Total synthesis of (+)-fawcettimine. Angewandte Chemie (International Ed. in English). 46: 7671-3. PMID 17729226 DOI: 10.1002/Anie.200702695  0.758
2006 Staben ST, Linghu X, Toste FD. Enantioselective synthesis of gamma-hydroxyenones by chiral base-catalyzed Kornblum DeLaMare rearrangement. Journal of the American Chemical Society. 128: 12658-9. PMID 17002354 DOI: 10.1021/Ja065464X  0.753
2006 Linghu X, Satterfield AD, Johnson JS. Symbiotic reagent activation: Oppenauer oxidation of magnesium alkoxides by silylglyoxylates triggers second-stage aldolization. Journal of the American Chemical Society. 128: 9302-3. PMID 16848444 DOI: 10.1021/Ja062637+  0.75
2006 Toste F, Staben S, Linghu X. Organocatalytic Asymmetric Kornblum-DeLaMare Rearrangement Synfacts. 2006: 1175-1175. DOI: 10.1055/S-2006-949454  0.736
2005 Nahm MR, Linghu X, Potnick JR, Yates CM, White PS, Johnson JS. Metallophosphite-induced nucleophilic acylation of alpha,beta-unsaturated amides: facilitated catalysis by a diastereoselective retro [1,4] Brook rearrangement. Angewandte Chemie (International Ed. in English). 44: 2377-9. PMID 15761891 DOI: 10.1002/Anie.200462795  0.706
2005 Linghu X, Bausch CC, Johnson JS. Mechanism and scope of the cyanide-catalyzed cross silyl benzoin reaction. Journal of the American Chemical Society. 127: 1833-40. PMID 15701019 DOI: 10.1021/Ja044086Y  0.807
2004 Linghu X, Potnick JR, Johnson JS. Metallophosphites as umpolung catalysts: the enantioselective cross silyl benzoin reaction. Journal of the American Chemical Society. 126: 3070-1. PMID 15012135 DOI: 10.1021/Ja0496468  0.69
2003 Linghu X, Johnson JS. Kinetic control in direct alpha-silyloxy ketone synthesis: a new regiospecific catalyzed cross silyl benzoin reaction. Angewandte Chemie (International Ed. in English). 42: 2534-6. PMID 12800180 DOI: 10.1002/Anie.200250554  0.656
2002 Linghu X, Nicewicz DA, Johnson JS. Tandem carbon-carbon bond constructions via catalyzed cyanation/Brook rearrangement/C-acylation reactions of acylsilanes. Organic Letters. 4: 2957-60. PMID 12182598 DOI: 10.1021/Ol0263649  0.787
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