| Year |
Citation |
Score |
| 2021 |
Duan Z, Baughn LB, Wang X, Zhang Y, Gupta V, MacCarthy T, Scharff MD, Yu G. Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34253616 DOI: 10.1073/pnas.2104013118 |
0.302 |
|
| 2020 |
Tang C, Bagnara D, Chiorazzi N, Scharff MD, MacCarthy T. AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes. Frontiers in Immunology. 11: 788. PMID 32425948 DOI: 10.3389/Fimmu.2020.00788 |
0.413 |
|
| 2020 |
Bartholdy BA, Wang X, Yan XJ, Pascual M, Fan M, Barrientos J, Allen SL, Martinez-Climent JA, Rai KR, Chiorazzi N, Scharff MD, Roa S. CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. Blood Advances. 4: 893-905. PMID 32150608 DOI: 10.1182/Bloodadvances.2019000817 |
0.346 |
|
| 2018 |
Wang X, Duan Z, Yu G, Fan M, Scharff MD. Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells. Mbio. 9. PMID 29666292 DOI: 10.1128/Mbio.02315-17 |
0.312 |
|
| 2015 |
Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T. Overlapping hotspots in CDRs are critical sites for V region diversification. Proceedings of the National Academy of Sciences of the United States of America. 112: E728-37. PMID 25646473 DOI: 10.1073/Pnas.1500788112 |
0.393 |
|
| 2014 |
Varshney AK, Wang X, Aguilar JL, Scharff MD, Fries BC. Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. Mbio. 5: e01007-14. PMID 24917594 DOI: 10.1128/Mbio.01007-14 |
0.422 |
|
| 2014 |
Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC. Erratum: Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against Staphylococcal enterotoxin B-induced lethal shock (Journal of Biological Chemistry (2011) 286 (9737-9747)) Journal of Biological Chemistry. 289. DOI: 10.1074/Jbc.A110.212407 |
0.359 |
|
| 2013 |
Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E2470-9. PMID 23754438 DOI: 10.1073/Pnas.1308512110 |
0.33 |
|
| 2013 |
Jaszczur M, Bertram JG, Pham P, Scharff MD, Goodman MF. AID and Apobec3G haphazard deamination and mutational diversity. Cellular and Molecular Life Sciences : Cmls. 70: 3089-108. PMID 23178850 DOI: 10.1007/S00018-012-1212-1 |
0.386 |
|
| 2012 |
Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, ... Scharff MD, et al. IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. Blood. 120: 4802-11. PMID 23071276 DOI: 10.1182/Blood-2012-08-449744 |
0.344 |
|
| 2012 |
Chahwan R, Edelmann W, Scharff MD, Roa S. AIDing antibody diversity by error-prone mismatch repair. Seminars in Immunology. 24: 293-300. PMID 22703640 DOI: 10.1016/J.Smim.2012.05.005 |
0.386 |
|
| 2012 |
Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S. The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. The Journal of Experimental Medicine. 209: 671-8. PMID 22451719 DOI: 10.1084/Jem.20111531 |
0.389 |
|
| 2012 |
Volpi SA, Verma-Gaur J, Hassan R, Ju Z, Roa S, Chatterjee S, Werling U, Hou H, Will B, Steidl U, Scharff M, Edelman W, Feeney AJ, Birshtein BK. Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. Journal of Immunology (Baltimore, Md. : 1950). 188: 2556-66. PMID 22345664 DOI: 10.4049/Jimmunol.1102763 |
0.762 |
|
| 2012 |
Sroubek J, Krishnan Y, Chinai J, Buhl S, Scharff MD, McDonald TV. The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel. Journal of Immunological Methods. 375: 215-22. PMID 22107967 DOI: 10.1016/J.Jim.2011.10.014 |
0.43 |
|
| 2011 |
Chahwan R, Edelmann W, Scharff MD, Roa S. Mismatch-mediated error prone repair at the immunoglobulin genes. Biomedicine & Pharmacotherapy = Biomã©Decine & Pharmacothã©Rapie. 65: 529-36. PMID 22100214 DOI: 10.1016/J.Biopha.2011.09.001 |
0.366 |
|
| 2011 |
Baughn LB, Kalis SL, MacCarthy T, Wei L, Fan M, Bergman A, Scharff MD. Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells. Mbio. 2. PMID 21990614 DOI: 10.1128/Mbio.00186-11 |
0.481 |
|
| 2011 |
Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, ... ... Scharff MD, et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Molecular Medicine (Cambridge, Mass.). 17: 1374-82. PMID 21968788 DOI: 10.2119/Molmed.2011.00360 |
0.314 |
|
| 2011 |
Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. The Journal of Biological Chemistry. 286: 9737-47. PMID 21233204 DOI: 10.1074/Jbc.M110.212407 |
0.416 |
|
| 2010 |
Peled JU, Sellers RS, Iglesias-Ussel MD, Shin DM, Montagna C, Zhao C, Li Z, Edelmann W, Morse HC, Scharff MD. Msh6 protects mature B cells from lymphoma by preserving genomic stability. The American Journal of Pathology. 177: 2597-608. PMID 20934970 DOI: 10.2353/Ajpath.2010.100234 |
0.352 |
|
| 2010 |
Abboud N, Chow SK, Saylor C, Janda A, Ravetch JV, Scharff MD, Casadevall A. A requirement for FcγR in antibody-mediated bacterial toxin neutralization. The Journal of Experimental Medicine. 207: 2395-405. PMID 20921285 DOI: 10.1084/Jem.20100995 |
0.43 |
|
| 2010 |
van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H, Sellers RS, Modrich P, Scharff MD, Edelmann W. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proceedings of the National Academy of Sciences of the United States of America. 107: 13384-9. PMID 20624957 DOI: 10.1073/Pnas.1008589107 |
0.342 |
|
| 2010 |
Roa S, Li Z, Peled JU, Zhao C, Edelmann W, Scharff MD. MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. Plos One. 5: e11182. PMID 20567595 DOI: 10.1371/Journal.Pone.0011182 |
0.324 |
|
| 2010 |
Peled JU, Yu JJ, Venkatesh J, Bi E, Ding BB, Krupski-Downs M, Shaknovich R, Sicinski P, Diamond B, Scharff MD, Ye BH. Requirement for cyclin D3 in germinal center formation and function. Cell Research. 20: 631-46. PMID 20404856 DOI: 10.1038/Cr.2010.55 |
0.333 |
|
| 2010 |
Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 809-14. PMID 20080757 DOI: 10.1073/Pnas.0913790107 |
0.592 |
|
| 2009 |
Iglesias-Ussel MD, Zavadil J, Scharff MD. Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro. Journal of Immunological Methods. 350: 71-8. PMID 19619554 DOI: 10.1016/J.Jim.2009.07.003 |
0.36 |
|
| 2009 |
MacCarthy T, Kalis SL, Roa S, Pham P, Goodman MF, Scharff MD, Bergman A. V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment. Proceedings of the National Academy of Sciences of the United States of America. 106: 8629-34. PMID 19443686 DOI: 10.1073/Pnas.0903803106 |
0.369 |
|
| 2009 |
Kuang FL, Luo Z, Scharff MD. H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 106: 5288-93. PMID 19276123 DOI: 10.1073/Pnas.0901368106 |
0.329 |
|
| 2009 |
Maccarthy T, Roa S, Scharff MD, Bergman A. SHMTool: a webserver for comparative analysis of somatic hypermutation datasets. Dna Repair. 8: 137-41. PMID 18952008 DOI: 10.1016/J.Dnarep.2008.09.006 |
0.376 |
|
| 2008 |
Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proceedings of the National Academy of Sciences of the United States of America. 105: 16248-53. PMID 18854411 DOI: 10.1073/Pnas.0808182105 |
0.428 |
|
| 2008 |
Roa S, Kuang FL, Scharff MD. Does antisense make sense of AID targeting? Proceedings of the National Academy of Sciences of the United States of America. 105: 3661-2. PMID 18322011 DOI: 10.1073/Pnas.0800935105 |
0.429 |
|
| 2008 |
Peled JU, Kuang FL, Iglesias-Ussel MD, Roa S, Kalis SL, Goodman MF, Scharff MD. The biochemistry of somatic hypermutation. Annual Review of Immunology. 26: 481-511. PMID 18304001 DOI: 10.1146/Annurev.Immunol.26.021607.090236 |
0.389 |
|
| 2008 |
Batova I, Kowal C, May R, Scharff MD, Diamond B. Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones. Journal of Immunological Methods. 329: 1-10. PMID 17976637 DOI: 10.1016/J.Jim.2007.08.019 |
0.382 |
|
| 2008 |
Peled JU, Yu JJ, Ding BB, Shaknovich R, Sicinski P, Scharff MD, Ye BH. Cyclin D3 Is Required for the Germinal Center Reaction Blood. 112: 2580-2580. DOI: 10.1182/Blood.V112.11.2580.2580 |
0.348 |
|
| 2007 |
Goodman MF, Scharff MD, Romesberg FE. AID-initiated purposeful mutations in immunoglobulin genes. Advances in Immunology. 94: 127-55. PMID 17560274 DOI: 10.1016/S0065-2776(06)94005-X |
0.451 |
|
| 2007 |
Ronai D, Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD. Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. The Journal of Experimental Medicine. 204: 181-90. PMID 17227912 DOI: 10.1084/Jem.20062032 |
0.608 |
|
| 2006 |
Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD. Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells. Journal of Immunological Methods. 316: 59-66. PMID 16997317 DOI: 10.1016/J.Jim.2006.08.002 |
0.61 |
|
| 2006 |
Li Z, Zhao C, Iglesias-Ussel MD, Polonskaya Z, Zhuang M, Yang G, Luo Z, Edelmann W, Scharff MD. The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity. 24: 393-403. PMID 16618598 DOI: 10.1016/J.Immuni.2006.02.011 |
0.311 |
|
| 2006 |
Li Z, Peled JU, Zhao C, Svetlanov A, Ronai D, Cohen PE, Scharff MD. A role for Mlh3 in somatic hypermutation. Dna Repair. 5: 675-82. PMID 16564751 DOI: 10.1016/J.Dnarep.2006.02.003 |
0.428 |
|
| 2005 |
Ronai D, Iglesias-Ussel MD, Fan M, Shulman MJ, Scharff MD. Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 11829-34. PMID 16087866 DOI: 10.1073/Pnas.0505449102 |
0.41 |
|
| 2005 |
Goodman MF, Scharff MD. Identifying protein-protein interactions in somatic hypermutation. The Journal of Experimental Medicine. 201: 493-6. PMID 15710655 DOI: 10.1084/jem.20050161 |
0.329 |
|
| 2005 |
Torres M, May R, Scharff MD, Casadevall A. Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype. Journal of Immunology (Baltimore, Md. : 1950). 174: 2132-42. PMID 15699144 DOI: 10.4049/Jimmunol.174.4.2132 |
0.399 |
|
| 2005 |
Larijani M, Frieder D, Sonbuchner TM, Bransteitter R, Goodman MF, Bouhassira EE, Scharff MD, Martin A. Methylation protects cytidines from AID-mediated deamination. Molecular Immunology. 42: 599-604. PMID 15607819 DOI: 10.1016/J.Molimm.2004.09.007 |
0.585 |
|
| 2004 |
Li Z, Luo Z, Scharff MD. Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching. Proceedings of the National Academy of Sciences of the United States of America. 101: 15428-33. PMID 15486086 DOI: 10.1073/Pnas.0406827101 |
0.342 |
|
| 2004 |
Luo Z, Ronai D, Scharff MD. The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies. The Journal of Allergy and Clinical Immunology. 114: 726-35; quiz 736. PMID 15480307 DOI: 10.1016/J.Jaci.2004.07.049 |
0.486 |
|
| 2004 |
Li Z, Scherer SJ, Ronai D, Iglesias-Ussel MD, Peled JU, Bardwell PD, Zhuang M, Lee K, Martin A, Edelmann W, Scharff MD. Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. The Journal of Experimental Medicine. 200: 47-59. PMID 15238604 DOI: 10.1084/Jem.20040355 |
0.603 |
|
| 2004 |
Li Z, Woo CJ, Iglesias-Ussel MD, Ronai D, Scharff MD. The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes & Development. 18: 1-11. PMID 14724175 DOI: 10.1101/Gad.1161904 |
0.443 |
|
| 2004 |
Bardwell PD, Woo CJ, Wei K, Li Z, Martin A, Sack SZ, Parris T, Edelmann W, Scharff MD. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nature Immunology. 5: 224-9. PMID 14716311 DOI: 10.1038/Ni1031 |
0.609 |
|
| 2003 |
Martin A, Li Z, Lin DP, Bardwell PD, Iglesias-Ussel MD, Edelmann W, Scharff MD. Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. The Journal of Experimental Medicine. 198: 1171-8. PMID 14568978 DOI: 10.1084/Jem.20030880 |
0.581 |
|
| 2003 |
May RJ, Beenhouwer DO, Scharff MD. Antibodies to keyhole limpet hemocyanin cross-react with an epitope on the polysaccharide capsule of Cryptococcus neoformans and other carbohydrates: implications for vaccine development. Journal of Immunology (Baltimore, Md. : 1950). 171: 4905-12. PMID 14568972 DOI: 10.4049/Jimmunol.171.9.4905 |
0.3 |
|
| 2003 |
Woo CJ, Martin A, Scharff MD. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity. 19: 479-89. PMID 14563313 DOI: 10.1016/S1074-7613(03)00261-9 |
0.582 |
|
| 2003 |
Li Z, Woo CJ, Scharff MD. Mutations in AID and UNG extend the function of AID. Nature Immunology. 4: 945-6. PMID 14515126 DOI: 10.1038/Ni1003-945 |
0.307 |
|
| 2003 |
Bardwell PD, Martin A, Wong E, Li Z, Edelmann W, Scharff MD. Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. Journal of Immunology (Baltimore, Md. : 1950). 170: 1620-4. PMID 12574322 DOI: 10.4049/Jimmunol.170.4.1620 |
0.588 |
|
| 2002 |
Beenhouwer DO, May RJ, Valadon P, Scharff MD. High affinity mimotope of the polysaccharide capsule of Cryptococcus neoformans identified from an evolutionary phage peptide library. Journal of Immunology (Baltimore, Md. : 1950). 169: 6992-9. PMID 12471134 DOI: 10.4049/Jimmunol.169.12.6992 |
0.325 |
|
| 2002 |
Martin A, Scharff MD. Somatic hypermutation of the AID transgene in B and non-B cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 12304-8. PMID 12202747 DOI: 10.1073/Pnas.192442899 |
0.612 |
|
| 2002 |
Martin A, Scharff MD. AID and mismatch repair in antibody diversification. Nature Reviews. Immunology. 2: 605-14. PMID 12154379 DOI: 10.1038/Nri858 |
0.606 |
|
| 2002 |
Bardwell PD, Martin A, Scharff MD. Mutation detection of immunoglobulin V-regions by DHPLC. Journal of Immunological Methods. 266: 165-73. PMID 12133633 DOI: 10.1016/S0022-1759(02)00147-3 |
0.599 |
|
| 2002 |
Shapiro S, Beenhouwer DO, Feldmesser M, Taborda C, Carroll MC, Casadevall A, Scharff MD. Immunoglobulin G monoclonal antibodies to Cryptococcus neoformans protect mice deficient in complement component C3. Infection and Immunity. 70: 2598-604. PMID 11953401 DOI: 10.1128/Iai.70.5.2598-2604.2002 |
0.341 |
|
| 2002 |
Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature. 415: 802-6. PMID 11823785 DOI: 10.1038/Nature714 |
0.616 |
|
| 2001 |
Sack SZ, Bardwell PD, Scharff MD. Testing the reverse transcriptase model of somatic mutation. Molecular Immunology. 38: 303-11. PMID 11566323 DOI: 10.1016/S0161-5890(01)00058-X |
0.384 |
|
| 2001 |
Beenhouwer DO, Shapiro S, Feldmesser M, Casadevall A, Scharff MD. Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans. Infection and Immunity. 69: 6445-55. PMID 11553589 DOI: 10.1128/Iai.69.10.6445-6455.2001 |
0.322 |
|
| 2001 |
Martin A, Scharff MD. Immunology. Antibody alterations. Nature. 412: 870-1. PMID 11528462 DOI: 10.1038/35091184 |
0.365 |
|
| 2001 |
Zhang W, Bardwell PD, Woo CJ, Poltoratsky V, Scharff MD, Martin A. Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line. International Immunology. 13: 1175-84. PMID 11526098 DOI: 10.1093/Intimm/13.9.1175 |
0.388 |
|
| 2001 |
Poltoratsky V, Woo CJ, Tippin B, Martin A, Goodman MF, Scharff MD. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proceedings of the National Academy of Sciences of the United States of America. 98: 7976-81. PMID 11427727 DOI: 10.1073/Pnas.141222198 |
0.39 |
|
| 2000 |
Poltoratsky V, Goodman MF, Scharff MD. Error-prone candidates vie for somatic mutation. The Journal of Experimental Medicine. 192: F27-30. PMID 11085756 DOI: 10.1084/Jem.192.10.F27 |
0.485 |
|
| 2000 |
Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. The Journal of Experimental Medicine. 191: 579-84. PMID 10662804 DOI: 10.1084/Jem.191.3.579 |
0.339 |
|
| 1999 |
Nussbaum G, Anandasabapathy S, Mukherjee J, Fan M, Casadevall A, Scharff MD. Molecular and idiotypic analyses of the antibody response to Cryptococcus neoformans glucuronoxylomannan-protein conjugate vaccine in autoimmune and nonautoimmune mice. Infection and Immunity. 67: 4469-76. PMID 10456888 DOI: 10.1128/Iai.67.9.4469-4476.1999 |
0.41 |
|
| 1998 |
Wiesendanger M, Scharff MD, Edelmann W. Somatic hypermutation, transcription, and DNA mismatch repair. Cell. 94: 415-8. PMID 9727483 DOI: 10.1016/S0092-8674(00)81581-0 |
0.328 |
|
| 1998 |
Lin MM, Green NS, Zhang W, Scharff MD. The effects of E mu, 3'alpha (hs 1,2) and 3'kappa enhancers on mutation of an Ig-VDJ-Cgamma2a Ig heavy gene in cultured B cells. International Immunology. 10: 1121-9. PMID 9723698 DOI: 10.1093/Intimm/10.8.1121 |
0.406 |
|
| 1998 |
Green NS, Lin MM, Scharff MD. Somatic hypermutation of antibody genes: a hot spot warms up. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 227-34. PMID 9631650 DOI: 10.1002/(Sici)1521-1878(199803)20:3<227::Aid-Bies6>3.0.Co;2-O |
0.439 |
|
| 1998 |
Casadevall A, Cleare W, Feldmesser M, Glatman-Freedman A, Goldman DL, Kozel TR, Lendvai N, Mukherjee J, Pirofski LA, Rivera J, Rosas AL, Scharff MD, Valadon P, Westin K, Zhong Z. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. Antimicrobial Agents and Chemotherapy. 42: 1437-46. PMID 9624491 DOI: 10.1128/Aac.42.6.1437 |
0.399 |
|
| 1998 |
Yuan RR, Spira G, Oh J, Paizi M, Casadevall A, Scharff MD. Isotype switching increases efficacy of antibody protection against Cryptococcus neoformans infection in mice. Infection and Immunity. 66: 1057-62. PMID 9488395 DOI: 10.1128/Iai.66.3.1057-1062.1998 |
0.416 |
|
| 1998 |
Yuan R, Clynes R, Oh J, Ravetch JV, Scharff MD. Antibody-mediated modulation of Cryptococcus neoformans infection is dependent on distinct Fc receptor functions and IgG subclasses. The Journal of Experimental Medicine. 187: 641-8. PMID 9463414 DOI: 10.1084/Jem.187.4.641 |
0.413 |
|
| 1997 |
Young AC, Valadon P, Casadevall A, Scharff MD, Sacchettini JC. The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes. Journal of Molecular Biology. 274: 622-34. PMID 9417940 DOI: 10.1006/Jmbi.1997.1407 |
0.327 |
|
| 1997 |
Lin MM, Zhu M, Scharff MD. Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 5284-9. PMID 9144229 DOI: 10.1073/Pnas.94.10.5284 |
0.38 |
|
| 1997 |
Yuan RR, Casadevall A, Oh J, Scharff MD. T cells cooperate with passive antibody to modify Cryptococcus neoformans infection in mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 2483-8. PMID 9122221 DOI: 10.1073/Pnas.94.6.2483 |
0.386 |
|
| 1997 |
Gaynor B, Putterman C, Valadon P, Spatz L, Scharff MD, Diamond B. Peptide inhibition of glomerular deposition of an anti-DNA antibody. Proceedings of the National Academy of Sciences of the United States of America. 94: 1955-60. PMID 9050886 DOI: 10.1073/Pnas.94.5.1955 |
0.368 |
|
| 1997 |
Nussbaum G, Cleare W, Casadevall A, Scharff MD, Valadon P. Epitope location in the Cryptococcus neoformans capsule is a determinant of antibody efficacy. The Journal of Experimental Medicine. 185: 685-94. PMID 9034147 DOI: 10.1084/Jem.185.4.685 |
0.358 |
|
| 1997 |
Scharff MD, Poltoratsky V, Green NS. The promotion of V region hypermutation. The Journal of Experimental Medicine. 185: 185-8. PMID 9016867 DOI: 10.1084/Jem.185.2.185 |
0.413 |
|
| 1996 |
Lin M, Spira G, Scharff MD. Molecular comparison of cultured hybridoma cells that switch isotypes at high and low rates. Somatic Cell and Molecular Genetics. 22: 329-40. PMID 9000175 DOI: 10.1007/Bf02369570 |
0.346 |
|
| 1996 |
Valadon P, Scharff MD. Enhancement of ELISAs for screening peptides in epitope phage display libraries. Journal of Immunological Methods. 197: 171-9. PMID 8890904 DOI: 10.1016/0022-1759(96)00133-0 |
0.371 |
|
| 1996 |
Nussbaum G, Yuan R, Casadevall A, Scharff MD. Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans. The Journal of Experimental Medicine. 183: 1905-9. PMID 8666947 DOI: 10.1084/Jem.183.4.1905 |
0.402 |
|
| 1996 |
Zhu M, Green NS, Rabinowitz JL, Scharff MD. Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines. The Embo Journal. 15: 2738-47. PMID 8654371 DOI: 10.1002/J.1460-2075.1996.Tb00634.X |
0.375 |
|
| 1995 |
Mukherjee J, Nussbaum G, Scharff MD, Casadevall A. Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell. The Journal of Experimental Medicine. 181: 405-9. PMID 7807020 DOI: 10.1084/Jem.181.1.405 |
0.438 |
|
| 1995 |
Zhu M, Rabinowitz JL, Green NS, Kobrin BJ, Scharff MD. A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proceedings of the National Academy of Sciences of the United States of America. 92: 2810-4. PMID 7708729 DOI: 10.1073/Pnas.92.7.2810 |
0.394 |
|
| 1995 |
Mukherjee J, Scharff MD, Casadevall A. Variable efficacy of passive antibody administration against diverse Cryptococcus neoformans strains. Infection and Immunity. 63: 3353-9. PMID 7642262 DOI: 10.1128/Iai.63.9.3353-3359.1995 |
0.309 |
|
| 1995 |
Green NS, Rabinowitz JL, Zhu M, Kobrin BJ, Scharff MD. Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line. Proceedings of the National Academy of Sciences of the United States of America. 92: 6304-8. PMID 7603987 DOI: 10.1073/Pnas.92.14.6304 |
0.412 |
|
| 1995 |
Casadevall A, Scharff MD. Return to the past: the case for antibody-based therapies in infectious diseases. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 21: 150-61. PMID 7578724 DOI: 10.1093/Clinids/21.1.150 |
0.338 |
|
| 1995 |
Mukherjee J, Feldmesser M, Scharff MD, Casadevall A. Monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan enhance fluconazole efficacy. Antimicrobial Agents and Chemotherapy. 39: 1398-405. PMID 7492075 DOI: 10.1128/Aac.39.7.1398 |
0.362 |
|
| 1994 |
Mukherjee S, Lee S, Mukherjee J, Scharff MD, Casadevall A. Monoclonal antibodies to Cryptococcus neoformans capsular polysaccharide modify the course of intravenous infection in mice. Infection and Immunity. 62: 1079-88. PMID 8112842 DOI: 10.1128/Iai.62.3.1079-1088.1994 |
0.331 |
|
| 1994 |
Mukherjee J, Scharff MD, Casadevall A. Cryptococcus neoformans infection can elicit protective antibodies in mice. Canadian Journal of Microbiology. 40: 888-92. PMID 8000967 DOI: 10.1139/M94-141 |
0.347 |
|
| 1994 |
Zebedee SL, Koduri RK, Mukherjee J, Mukherjee S, Lee S, Sauer DF, Scharff MD, Casadevall A. Mouse-human immunoglobulin G1 chimeric antibodies with activities against Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 38: 1507-14. PMID 7979280 DOI: 10.1128/Aac.38.7.1507 |
0.426 |
|
| 1994 |
Kobrin BJ, Schiff C, Zivion D, Scharff MD, Spira G. In vitro activation of a nonproductive immunoglobulin allele by a single base pair insertion. Hybridoma. 13: 257-61. PMID 7806247 DOI: 10.1089/Hyb.1994.13.257 |
0.366 |
|
| 1993 |
Mukherjee J, Pirofski LA, Scharff MD, Casadevall A. Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection. Proceedings of the National Academy of Sciences of the United States of America. 90: 3636-40. PMID 8475112 DOI: 10.1073/Pnas.90.8.3636 |
0.341 |
|
| 1993 |
Mukherjee J, Casadevall A, Scharff MD. Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. The Journal of Experimental Medicine. 177: 1105-16. PMID 8459205 DOI: 10.1084/Jem.177.4.1105 |
0.408 |
|
| 1993 |
Mukherjee J, Casadevall A, Scharff MD. Mu switch region deletion is associated with both T cell independent and T cell dependent responses. Molecular Immunology. 30: 1049-55. PMID 8350875 DOI: 10.1016/0161-5890(93)90130-4 |
0.369 |
|
| 1993 |
Spira G, Gregor PD, Scharff MD. The use of chemiluminescence and the ELISA spot assay to identify and enumerate rare immunoglobulin switch variants. Journal of Immunological Methods. 165: 263-8. PMID 8228276 DOI: 10.1016/0022-1759(93)90352-8 |
0.311 |
|
| 1993 |
Pirofski LA, Thomas EK, Scharff MD. Variable region gene utilization and mutation in a group of neutralizing murine anti-human immunodeficiency virus type 1 principal neutralizing determinant antibodies. Aids Research and Human Retroviruses. 9: 41-9. PMID 7678971 DOI: 10.1089/Aid.1993.9.41 |
0.402 |
|
| 1992 |
Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD. The role of somatic mutation in the pathogenic anti-DNA response. Annual Review of Immunology. 10: 731-57. PMID 1591002 DOI: 10.1146/Annurev.Iy.10.040192.003503 |
0.448 |
|
| 1992 |
Spira G, Scharff MD. Identification of rare immunoglobulin switch variants using the ELISA spot assay. Journal of Immunological Methods. 148: 121-9. PMID 1564322 DOI: 10.1016/0022-1759(92)90165-P |
0.306 |
|
| 1992 |
Casadevall A, Mukherjee J, Scharff MD. Monoclonal antibody based ELISAs for cryptococcal polysaccharide. Journal of Immunological Methods. 154: 27-35. PMID 1401941 DOI: 10.1016/0022-1759(92)90209-C |
0.383 |
|
| 1992 |
Mukherjee J, Scharff MD, Casadevall A. Protective murine monoclonal antibodies to Cryptococcus neoformans. Infection and Immunity. 60: 4534-41. PMID 1398966 DOI: 10.1128/Iai.60.11.4534-4541.1992 |
0.413 |
|
| 1991 |
Kobrin BJ, Buhl S, Shulman MJ, Scharff MD. A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding. Journal of Immunology (Baltimore, Md. : 1950). 146: 2017-20. PMID 2005389 |
0.311 |
|
| 1991 |
Shin SU, DePinho R, Zack DJ, Rudikoff S, Scharff MD. Instability of immunoglobulin genes in S107 cell line. Somatic Cell and Molecular Genetics. 17: 259-76. PMID 1904631 DOI: 10.1007/Bf01232821 |
0.674 |
|
| 1991 |
Behar SM, Lustgarten DL, Corbet S, Scharff MD. Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice. The Journal of Experimental Medicine. 173: 731-41. PMID 1900082 DOI: 10.1084/Jem.173.3.731 |
0.68 |
|
| 1991 |
Casadevall A, Scharff MD. The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies. The Journal of Experimental Medicine. 174: 151-60. PMID 1676047 DOI: 10.1084/Jem.174.1.151 |
0.441 |
|
| 1991 |
French DL, Pollock RR, Aguila HL, Scharff MD. The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding. Journal of Immunology (Baltimore, Md. : 1950). 146: 2010-6. PMID 1672339 |
0.336 |
|
| 1990 |
Pollock RR, French DL, Metlay JP, Birshtein BK, Scharff MD. Intravascular metabolism of normal and mutant mouse immunoglobulin molecules. European Journal of Immunology. 20: 2021-7. PMID 2120072 DOI: 10.1002/Eji.1830200921 |
0.637 |
|
| 1990 |
Pirofski L, Casadevall A, Rodriguez L, Zuckier LS, Scharff MD. Current state of the hybridoma technology. Journal of Clinical Immunology. 10: 5S-12S; discussion 1. PMID 2081790 DOI: 10.1007/Bf00918686 |
0.375 |
|
| 1989 |
Chien NC, Roberts VA, Giusti AM, Scharff MD, Getzoff ED. Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism. Proceedings of the National Academy of Sciences of the United States of America. 86: 5532-6. PMID 2748602 DOI: 10.1073/Pnas.86.14.5532 |
0.367 |
|
| 1989 |
Zuckier LS, Rodriguez LD, Scharff MD. Immunologic and pharmacologic concepts of monoclonal antibodies. Seminars in Nuclear Medicine. 19: 166-86. PMID 2669128 DOI: 10.1016/S0001-2998(89)80012-1 |
0.413 |
|
| 1989 |
French DL, Laskov R, Scharff MD. The role of somatic hypermutation in the generation of antibody diversity. Science (New York, N.Y.). 244: 1152-7. PMID 2658060 |
0.309 |
|
| 1989 |
Behar SM, Chien NC, Corbet S, Diamond B, Getzoff ED, Lustgarten D, Roberts VA, Scharff MD, Shin SU. Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself. Cold Spring Harbor Symposia On Quantitative Biology. 54: 921-31. PMID 2518013 DOI: 10.1101/Sqb.1989.054.01.107 |
0.635 |
|
| 1989 |
Behar SM, Corbet S, Diamond B, Scharff MD. The molecular origin of anti-DNA antibodies. International Reviews of Immunology. 5: 23-42. PMID 2491158 DOI: 10.3109/08830188909086988 |
0.666 |
|
| 1988 |
Pollock RR, French DL, Gefter ML, Scharff MD. Identification of mutant monoclonal antibodies with increased antigen binding. Proceedings of the National Academy of Sciences of the United States of America. 85: 2298-302. PMID 3267219 DOI: 10.1073/pnas.85.7.2298 |
0.3 |
|
| 1988 |
Behar SM, Scharff MD. Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice. Proceedings of the National Academy of Sciences of the United States of America. 85: 3970-4. PMID 3131767 DOI: 10.1073/Pnas.85.11.3970 |
0.658 |
|
| 1988 |
Chien NC, Pollock RR, Desaymard C, Scharff MD. Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies. The Journal of Experimental Medicine. 167: 954-73. PMID 3127529 DOI: 10.1084/Jem.167.3.954 |
0.446 |
|
| 1988 |
Behar SM, Scharff MD. Somatic diversification of anti-DNA antibodies Annals of the New York Academy of Sciences. 546: 188. DOI: 10.1111/J.1749-6632.1988.Tb21634.X |
0.623 |
|
| 1987 |
Albright JF, Scharff MD. Generation and maintenance of hybridomas. Immunology Today. 8: 256-7. PMID 25344275 DOI: 10.1016/0167-5699(87)90179-4 |
0.393 |
|
| 1987 |
French D, Kelly T, Buhl S, Scharff MD. Somatic cell genetic analysis of myelomas and hybridomas. Methods in Enzymology. 151: 50-66. PMID 3431452 DOI: 10.1016/S0076-6879(87)51008-4 |
0.372 |
|
| 1987 |
Scharff MD, Aguila HL, Behar SM, Chien NC, DePinho R, French DL, Pollock RR, Shin SU. Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells. Immunological Reviews. 96: 75-90. PMID 3298011 DOI: 10.1111/J.1600-065X.1987.Tb00510.X |
0.722 |
|
| 1987 |
Giusti AM, Chien NC, Zack DJ, Shin SU, Scharff MD. Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region. Proceedings of the National Academy of Sciences of the United States of America. 84: 2926-30. PMID 3106981 DOI: 10.1073/Pnas.84.9.2926 |
0.628 |
|
| 1986 |
Agulla HL, Pollock RR, Spira G, Scharff MD. The production of more useful monoclonal antibodies 2. The use of somatic-cell genetic and recombinant-DNA technology to tailor-make monoclonal antibodies. Immunology Today. 7: 380-3. PMID 25291336 DOI: 10.1016/0167-5699(86)90031-9 |
0.409 |
|
| 1986 |
French D, Fischberg E, Buhl S, Scharff MD. The production of more useful monoclonal antibodies I. Modifications of the basic technology. Immunology Today. 7: 344-6. PMID 25291104 DOI: 10.1016/0167-5699(86)90142-8 |
0.36 |
|
| 1986 |
Scharff MD, DePinho RA, Behar S, Beychok C, Shin SU, French D. The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. Cellular Immunology. 99: 29-37. PMID 3093101 DOI: 10.1016/0008-8749(86)90212-1 |
0.697 |
|
| 1986 |
DePinho RA, Feldman LB, Scharff MD. Tailor-made monoclonal antibodies. Annals of Internal Medicine. 104: 225-33. PMID 3080934 DOI: 10.7326/0003-4819-104-2-225 |
0.537 |
|
| 1985 |
Spira G, Pollock RR, Bargellesi A, Scharff MD. Monoclonal antibodies: a potentially powerful tool in the diagnosis and treatment of infectious diseases. European Journal of Clinical Microbiology. 4: 251-6. PMID 2410264 DOI: 10.1007/Bf02013647 |
0.352 |
|
| 1984 |
Spira G, Bargellesi A, Teillaud JL, Scharff MD. The identification of monoclonal class switch variants by sib selection and an ELISA assay. Journal of Immunological Methods. 74: 307-15. PMID 6438240 DOI: 10.1016/0022-1759(84)90298-9 |
0.412 |
|
| 1984 |
Diamond B, Scharff MD. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proceedings of the National Academy of Sciences of the United States of America. 81: 5841-4. PMID 6435121 DOI: 10.1073/Pnas.81.18.5841 |
0.412 |
|
| 1984 |
Desaymard C, Giusti AM, Scharff MD. Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopes. Molecular Immunology. 21: 961-7. PMID 6209566 DOI: 10.1016/0161-5890(84)90154-8 |
0.378 |
|
| 1984 |
Pollock RR, Teillaud JL, Scharff MD. Monoclonal antibodies: a powerful tool for selecting and analyzing mutations in antigens and antibodies. Annual Review of Microbiology. 38: 389-417. PMID 6208844 DOI: 10.1146/Annurev.Mi.38.100184.002133 |
0.395 |
|
| 1983 |
Thammana P, Scharff MD. Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma. European Journal of Immunology. 13: 614-9. PMID 6884421 DOI: 10.1002/Eji.1830130803 |
0.403 |
|
| 1983 |
Teillaud JL, Desaymard C, Giusti AM, Haseltine B, Pollock RR, Yelton DE, Zack DJ, Scharff MD. Monoclonal antibodies reveal the structural basis of antibody diversity. Science (New York, N.Y.). 222: 721-6. PMID 6356353 DOI: 10.1126/Science.6356353 |
0.614 |
|
| 1982 |
Scharff MD. Somatic cell genetics of immunoglobulin production. Cellular Immunology. 66: 29-33. PMID 7044566 DOI: 10.1016/0008-8749(82)90153-8 |
0.365 |
|
| 1982 |
Yelton DE, Scharff MD. Mutant monoclonal antibodies with alterations in biological functions. The Journal of Experimental Medicine. 156: 1131-48. PMID 6818317 |
0.321 |
|
| 1982 |
Cook WD, Rudikoff S, Giusti AM, Scharff MD. Somatic mutation in a cultured mouse myeloma cell affects antigen binding. Proceedings of the National Academy of Sciences of the United States of America. 79: 1240-4. PMID 6803237 DOI: 10.1073/Pnas.79.4.1240 |
0.453 |
|
| 1981 |
Zack DJ, Morrison SL, Cook WD, Dackowski W, Scharff MD. Somatically generated mouse myeloma variants synthesizing IgA half-molecules. The Journal of Experimental Medicine. 154: 1554-69. PMID 7299348 DOI: 10.1084/Jem.154.5.1554 |
0.58 |
|
| 1981 |
Scharff MD, Roberts S. Present status and future prospects for the hybridoma technology. In Vitro. 17: 1072-7. PMID 6976303 DOI: 10.1007/Bf02618605 |
0.308 |
|
| 1981 |
Yelton DE, Desaymard C, Scharff MD. Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies. Hybridoma. 1: 5-11. PMID 6821395 DOI: 10.1089/Hyb.1.1981.1.5 |
0.41 |
|
| 1981 |
Kwan SP, Max EE, Seidman JG, Leder P, Scharff MD. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell. 26: 57-66. PMID 6799208 DOI: 10.1016/0092-8674(81)90033-7 |
0.382 |
|
| 1981 |
Leder P, Max EE, Seidman JG, Kwan SP, Scharff M, Nau M, Norman B. Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harbor Symposia On Quantitative Biology. 45: 859-65. PMID 6790218 DOI: 10.1101/Sqb.1981.045.01.103 |
0.384 |
|
| 1981 |
Kwan SP, Rudikoff S, Seidman JG, Leder P, Scharff MD. Nucleic acid and protein sequences of phosphocholine-binding light chains. The Journal of Experimental Medicine. 153: 1366-70. PMID 6788890 DOI: 10.1084/Jem.153.5.1366 |
0.334 |
|
| 1981 |
Scharff MD, Roberts S, Thammana P. Hybridomas as a source of antibodies. Hospital Practice (Office Ed.). 16: 61-6. PMID 6786973 DOI: 10.1080/21548331.1981.11946708 |
0.402 |
|
| 1981 |
Diamond BA, Yelton DE, Scharff MD. Monoclonal antibodies. A new technique for producing serologic reagents. The New England Journal of Medicine. 304: 1344-9. PMID 6783911 DOI: 10.1056/Nejm198105283042208 |
0.348 |
|
| 1980 |
Cieplinski W, Scharff MD. Membrane-associated ribosomes in producing and nonproducing mouse myeloma cells. Journal of Cellular Physiology. 103: 447-53. PMID 7400226 DOI: 10.1002/Jcp.1041030310 |
0.302 |
|
| 1980 |
Seidman JG, Nau MM, Norman B, Kwan SP, Scharff M, Leder P. Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. Proceedings of the National Academy of Sciences of the United States of America. 77: 6022-6. PMID 6777777 DOI: 10.1073/Pnas.77.10.6022 |
0.376 |
|
| 1980 |
Cook WD, Rudikoff S, Giusti AM, Zack DJ, Kelly T, Scharff MD. Antigen binding variants of the S107 mouse myeloma cell line. Progress in Clinical and Biological Research. 42: 217-30. PMID 6771769 |
0.507 |
|
| 1979 |
Diamond B, Birshtein BK, Scharff MD. Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages. The Journal of Experimental Medicine. 150: 721-6. PMID 479765 DOI: 10.1084/Jem.150.3.721 |
0.639 |
|
| 1979 |
Morrison SL, Scharff MD. A mouse myeloma variant with a defect in light chain synthesis. European Journal of Immunology. 9: 461-5. PMID 115696 DOI: 10.1002/Eji.1830090609 |
0.355 |
|
| 1978 |
Hurley JN, Fu SM, Kunkel HG, McKenna G, Scharff MD. Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis. Proceedings of the National Academy of Sciences of the United States of America. 75: 5706-10. PMID 82971 DOI: 10.1073/Pnas.75.11.5706 |
0.359 |
|
| 1978 |
Francus T, Dharmgrongartama B, Campbell R, Scharff MD, Birshtein BK. IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line. The Journal of Experimental Medicine. 147: 1535-50. PMID 79633 DOI: 10.1084/Jem.147.6.1535 |
0.637 |
|
| 1977 |
Gefter ML, Margulies DH, Scharff MD. A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells. Somatic Cell Genetics. 3: 231-6. PMID 605383 DOI: 10.1007/Bf01551818 |
0.314 |
|
| 1977 |
Weitzman S, Nathenson SG, Scharff MD. Abnormalities in the glycosylation of immunoglobulin heavy chain and an h-2 transplantation antigen in a mouse myeloma mutant. Cell. 10: 679-87. PMID 405105 DOI: 10.1016/0092-8674(77)90101-5 |
0.342 |
|
| 1977 |
Cook WD, Scharff MD. Antigen-binding mutants of mouse myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 5687-91. PMID 271995 DOI: 10.1073/Pnas.74.12.5687 |
0.42 |
|
| 1976 |
Rajan TV, Nathenson SG, Scharff MD. Regulatory variants for the expression of H-2 antigens. I. Isolation and characterization. Journal of the National Cancer Institute. 56: 1221-7. PMID 994223 DOI: 10.1093/Jnci/56.6.1221 |
0.353 |
|
| 1976 |
Margulies DH, Kuehl WM, Scharff MD. Somatic cell hybridization of mouse myeloma cells. Cell. 8: 405-15. PMID 821618 DOI: 10.1016/0092-8674(76)90153-7 |
0.317 |
|
| 1976 |
Weitzman S, Margulies DH, Scharff MD. Mutations in mouse myeloma cells: implications for human multiple myeloma and the production of immunoglobulins. Annals of Internal Medicine. 85: 110-6. PMID 820230 DOI: 10.7326/0003-4819-85-1-110 |
0.397 |
|
| 1976 |
Weitzman S, Scharff MD. Mouse myeloma mutants blocked in the assembly, glycosylation and secretion of immunoglobulin. Journal of Molecular Biology. 102: 237-52. PMID 818392 DOI: 10.1016/S0022-2836(76)80051-4 |
0.323 |
|
| 1976 |
Bargellesi A, Damiani G, Kuehl WM, Scharff MD. Synthesis of immunoglobulin by substrate attached mouse myeloma cells. Journal of Cellular Physiology. 88: 247-51. PMID 818094 DOI: 10.1002/Jcp.1040880214 |
0.341 |
|
| 1975 |
Kuehl WM, Kaplan BA, Scharff MD. Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants. Cell. 5: 139-47. PMID 806346 DOI: 10.1016/0092-8674(75)90022-7 |
0.308 |
|
| 1975 |
Preud'Homme JL, Birshtein BK, Scharff MD. Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. Proceedings of the National Academy of Sciences of the United States of America. 72: 1427-30. PMID 805428 DOI: 10.1073/Pnas.72.4.1427 |
0.664 |
|
| 1974 |
Kuehl WM, Scharff MD. Synthesis of a carboxyl-terminal (constant region) fragment of the immunoglobulin light chain by a mouse myeloma cell line. Journal of Molecular Biology. 89: 409-21. PMID 4475118 DOI: 10.1016/0022-2836(74)90472-0 |
0.348 |
|
| 1974 |
Morrison SL, Baumal R, Birshtein BK, Kuehl UM, Preud'homme JL, Frank L, Jasek T, Scharff MD. The identification of mouse myeloma cells which have undergone mutations in immunoglobulin production. Society of General Physiologists Series. 29: 233-44. PMID 4215140 |
0.624 |
|
| 1974 |
Birshtein BK, Preud'homme JL, Scharff MD. Variants of mouse myeloma cells that produce short immunoglobulin heavy chains. Proceedings of the National Academy of Sciences of the United States of America. 71: 3478-82. PMID 4139712 DOI: 10.1073/Pnas.71.9.3478 |
0.662 |
|
| 1974 |
Laskov R, Scharff MD. Independent synthesis of light and heavy chains: quantitation of light-chain production by mouse myeloma variants. The Journal of Experimental Medicine. 140: 1112-6. PMID 4139223 DOI: 10.1084/Jem.140.4.1112 |
0.347 |
|
| 1973 |
Baumal R, Birshtein BK, Coffino P, Scharff MD. Mutations in immunoglobulin-producing mouse myeloma cells. Science (New York, N.Y.). 182: 164-6. PMID 4354174 DOI: 10.1126/Science.182.4108.164 |
0.672 |
|
| 1973 |
Prend'homme JL, Buxbaum J, Scharff MD. Mutagenesis of mouse myeloma cells with 'Melphalan'. Nature. 245: 320-2. PMID 4128217 DOI: 10.1038/245320A0 |
0.456 |
|
| 1972 |
Coffino P, Baumal R, Laskov R, Scharff MD. Cloning of mouse myeloma cells and detection of rare variants. Journal of Cellular Physiology. 79: 429-40. PMID 4625122 DOI: 10.1002/Jcp.1040790313 |
0.344 |
|
| 1971 |
Coffino P, Scharff MD. Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 68: 219-23. PMID 5276293 DOI: 10.1073/Pnas.68.1.219 |
0.355 |
|
| 1971 |
Baumal R, Potter M, Scharff MD. Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. 3. Assembly of the three subclasses of IgG. The Journal of Experimental Medicine. 134: 1316-34. PMID 5112205 DOI: 10.1084/Jem.134.5.1316 |
0.372 |
|
| 1971 |
Laskov R, Lanzerotti R, Scharff MD. Synthesis, assembly and secretion of gamma globulin by mouse myeloma cells. II. Assembly of IgG2b immunoglobulin by MPC 11 tumor and culture cells. Journal of Molecular Biology. 56: 327-39. PMID 5102530 DOI: 10.1016/0022-2836(71)90468-2 |
0.328 |
|
| 1971 |
Buxbaum J, Zolla S, Scharff MD, Franklin EC. Synthesis and assembly of immunoglobulins by malignant human plasmacytes and lymphocytes. II. Heterogeneity of assembly in cells producing IgM proteins. The Journal of Experimental Medicine. 133: 1118-30. PMID 4995064 DOI: 10.1084/Jem.133.5.1118 |
0.346 |
|
| 1971 |
Baumal R, Bloom B, Scharff MD. Induction of long term lymphocyte lines from delayed hypersensitive human donors using specific antigen plus Epstein-Barr virus. Nature: New Biology. 230: 20-1. PMID 4326813 DOI: 10.1038/Newbio230020A0 |
0.4 |
|
| 1971 |
Coffino P, Knowles B, Nathenson SG, Scharff MD. Suppression of immunoglobulin synthesis by cellular hybridization. Nature: New Biology. 231: 87-90. PMID 4103301 DOI: 10.1038/Newbio231087A0 |
0.313 |
|
| 1970 |
Zolla S, Buxbaum J, Franklin EC, Scharff MD. Synthesis and assembly of immunoglobulins by malignant human plasmacytes. I. Myelomas producing gamma-chains and light chains. The Journal of Experimental Medicine. 132: 148-62. PMID 5508244 DOI: 10.1084/Jem.132.1.148 |
0.316 |
|
| 1970 |
Buxbaum J, Franklin EC, Scharff MD. Immunoglobulin M heavy chain disease: intracellular origin of the mu chain fragment. Science (New York, N.Y.). 169: 770-3. PMID 5464612 DOI: 10.1126/Science.169.3947.770 |
0.311 |
|
| 1970 |
Darnell JE, Levintow L, Scharff MD. Harry Eagle. Journal of Cellular Physiology. 76: 241-52. PMID 4925975 DOI: 10.1002/Jcp.1040760304 |
0.585 |
|
| 1970 |
Laskov R, Scharff MD. Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits. The Journal of Experimental Medicine. 131: 515-41. PMID 4189836 DOI: 10.1084/Jem.131.3.515 |
0.321 |
|
| 1970 |
Coffino P, Laskov R, Scharff MD. Immunoglobulin production: method for quantitatively detecting variant myeloma cells. Science (New York, N.Y.). 167: 186-8. PMID 4188146 DOI: 10.1126/Science.167.3915.186 |
0.347 |
|
| 1970 |
Scharff MD, Bargellesi A, Baumal R, Buxbaum J, Coffino P, Laskov R. Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: a genetic and biochemical analysis. Journal of Cellular Physiology. 76: 331-48. PMID 4100579 DOI: 10.1002/Jcp.1040760311 |
0.315 |
|
| 1966 |
Shapiro AL, Scharff MD, Maizel JV, Uhr JW. Polyribosomal synthesis and assembly of the H and L chains of gamma globulin. Proceedings of the National Academy of Sciences of the United States of America. 56: 216-21. PMID 4165344 DOI: 10.1073/Pnas.56.1.216 |
0.33 |
|
| 1965 |
Scharff MD, Summers DF, Levintow L. Further studies on the effect of p-fluorophenylalanine and puromycin on polio virus replication. Annals of the New York Academy of Sciences. 130: 282-90. PMID 4285576 DOI: 10.1111/J.1749-6632.1965.Tb12561.X |
0.628 |
|
| 1964 |
SCHARFF MD, MAIZEL JV, LEVINTOW L. PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF A SOLUBLE PRECURSOR OF THE POLIOVIRUS CAPSID. Proceedings of the National Academy of Sciences of the United States of America. 51: 329-37. PMID 14124331 DOI: 10.1073/Pnas.51.2.329 |
0.632 |
|
| 1963 |
SCHARFF MD, SHATKIN AJ, LEVINTOW L. ASSOCIATION OF NEWLY FORMED VIRAL PROTEIN WITH SPECIFIC POLYRIBOSOMES. Proceedings of the National Academy of Sciences of the United States of America. 50: 686-94. PMID 14077498 DOI: 10.1073/Pnas.50.4.686 |
0.647 |
|
| 1963 |
SCHARFF MD, LEVINTOW L. Quantitative study of the formation of poliovirus antigens in infected HeLa cells. Virology. 19: 491-500. PMID 13976714 DOI: 10.1016/0042-6822(63)90043-6 |
0.661 |
|
| 1963 |
SCHARFF MD, THOREN MM, McELVAIN NF, LEVINTOW L. Interruption of poliovirus RNA synthesis by p-fluorophenylalanine and puromycin. Biochemical and Biophysical Research Communications. 10: 127-32. PMID 13976712 DOI: 10.1016/0006-291X(63)90037-8 |
0.595 |
|
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