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Kirsten S Smith - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
Chemistry, drug metabolism
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Chordia MD, McCalmont WF, Smith KS, Smith PL. Regioselective Synthesis and Biological Evaluation of 1-Hydroxyl Modified Ailanthinone Derivatives as Antimalarials Open Journal of Synthesis Theory and Applications. 2: 91-96. DOI: 10.4236/ojsta.2013.24012  0.741
2012 Perić M, Fajdetić A, Rupčić R, Alihodžić S, Ziher D, Bukvić Krajačić M, Smith KS, Ivezić-Schönfeld Z, Padovan J, Landek G, Jelić D, Hutinec A, Mesić M, Ager A, Ellis WY, et al. Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin. Journal of Medicinal Chemistry. 55: 1389-401. PMID 22148880 DOI: 10.1021/Jm201615T  0.41
2011 Bukvić Krajačić M, Perić M, Smith KS, Schönfeld ZI, Žiher D, Fajdetić A, Kujundžić N, Schönfeld W, Landek G, Padovan J, Jelić D, Ager A, Milhous WK, Ellis W, Spaventi R, et al. Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides. Journal of Medicinal Chemistry. 54: 3595-605. PMID 21476508 DOI: 10.1021/Jm2001585  0.316
2011 Hutinec A, Rupčić R, Ziher D, Smith KS, Milhous W, Ellis W, Ohrt C, Schönfeld ZI. An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics. Bioorganic & Medicinal Chemistry. 19: 1692-701. PMID 21316974 DOI: 10.1016/J.Bmc.2011.01.030  0.398
2010 Deveau AM, Labroli MA, Dieckhaus CM, Barthen MT, Smith KS, Macdonald TL. ChemInform Abstract: Synthesis of Amino-Acid Functionalized β-Carbolines as Topoisomerase II Inhibitors. Cheminform. 32: no-no. DOI: 10.1002/chin.200137147  0.697
2008 Opsenica I, Opsenica D, Lanteri CA, Anova L, Milhous WK, Smith KS, Solaja BA. New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton. Journal of Medicinal Chemistry. 51: 6216-9. PMID 18774792 DOI: 10.1021/Jm8006905  0.313
2008 Solaja BA, Opsenica D, Smith KS, Milhous WK, Terzić N, Opsenica I, Burnett JC, Nuss J, Gussio R, Bavari S. Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. Journal of Medicinal Chemistry. 51: 4388-91. PMID 18637666 DOI: 10.1021/Jm800737Y  0.399
2008 Opsenica DM, Terzić N, Smith PL, Yang Y, Anova L, Smith KS, Solaja BA. Mixed tetraoxanes containing the acetone subunit as antimalarials. Bioorganic & Medicinal Chemistry. 16: 7039-45. PMID 18550377 DOI: 10.1016/J.Bmc.2008.05.017  0.35
2008 Opsenica I, Opsenica D, Smith KS, Milhous WK, Solaja BA. Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials. Journal of Medicinal Chemistry. 51: 2261-6. PMID 18330976 DOI: 10.1021/Jm701417A  0.364
2008 Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/J.Bmc.2008.02.050  0.693
2008 Diaz DS, Kozar MP, Smith KS, Asher CO, Sousa JC, Schiehser GA, Jacobus DP, Milhous WK, Skillman DR, Shearer TW. Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 380-5. PMID 18006651 DOI: 10.1124/Dmd.106.013920  0.337
2007 Guan J, Wang X, Smith K, Ager A, Gettayacamin M, Kyle DE, Milhous WK, Kozar MP, Magill AJ, Lin AJ. Malaria causal prophylactic activity of imidazolidinedione derivatives. Journal of Medicinal Chemistry. 50: 6226-31. PMID 17967003 DOI: 10.1021/Jm7009815  0.339
2007 Terzić N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Solaja BA. Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1). Journal of Medicinal Chemistry. 50: 5118-27. PMID 17887664 DOI: 10.1021/Jm070684M  0.394
2007 Edstein MD, Kotecka BM, Ager AL, Smith KS, DiTusa CA, Diaz DS, Kyle DE, Schiehser GA, Jacobus DP, Rieckmann KH, O'Neil MT. Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model. The Journal of Antimicrobial Chemotherapy. 60: 811-8. PMID 17646199 DOI: 10.1093/Jac/Dkm280  0.348
2007 Opsenica I, Opsenica D, Jadranin M, Smith K, Milhous W, Stratakis M, Solaja B. On peroxide antimalarials Journal of the Serbian Chemical Society. 72: 1181-1190. DOI: 10.2298/Jsc0712181O  0.321
2006 Dow GS, Heady TN, Bhattacharjee AK, Caridha D, Gerena L, Gettayacamin M, Lanteri CA, Obaldia N, Roncal N, Shearer T, Smith PL, Tungtaeng A, Wolf L, Cabezas M, Yourick D, ... Smith KS, et al. Utility of alkylaminoquinolinyl methanols as new antimalarial drugs. Antimicrobial Agents and Chemotherapy. 50: 4132-43. PMID 16966402 DOI: 10.1128/Aac.00631-06  0.731
2006 Gutteridge CE, Nichols DA, Curtis SM, Thota DS, Vo JV, Gerena L, Montip G, Asher CO, Diaz DS, Ditusa CA, Smith KS, Bhattacharjee AK. In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters. 16: 5682-6. PMID 16908136 DOI: 10.1016/J.Bmcl.2006.08.009  0.379
2006 Opsenica I, Terzić N, Opsenica D, Angelovski G, Lehnig M, Eilbracht P, Tinant B, Juranić Z, Smith KS, Yang YS, Diaz DS, Smith PL, Milhous WK, Doković D, Solaja BA. Tetraoxane antimalarials and their reaction with Fe(II). Journal of Medicinal Chemistry. 49: 3790-9. PMID 16789736 DOI: 10.1021/Jm050966R  0.361
2005 Shearer TW, Smith KS, Diaz D, Asher C, Ramirez J. The role of in vitro ADME assays in antimalarial drug discovery and development. Combinatorial Chemistry & High Throughput Screening. 8: 89-98. PMID 15720200 DOI: 10.2174/1386207053328129  0.308
2003 Smith KS, Smith PL, Heady TN, Trugman JM, Harman WD, Macdonald TL. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity. Chemical Research in Toxicology. 16: 123-8. PMID 12588182 DOI: 10.1021/Tx025569N  0.704
2002 Zhao S, Smith KS, Deveau AM, Dieckhaus CM, Johnson MA, Macdonald TL, Cook JM. Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines. Journal of Medicinal Chemistry. 45: 1559-62. PMID 11931609 DOI: 10.1021/Jm0155953  0.682
2001 Deveau AM, Labroli MA, Dieckhaus CM, Barthen MT, Smith KS, Macdonald TL. The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 11: 1251-5. PMID 11392530 DOI: 10.1016/S0960-894X(01)00136-6  0.704
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