| Year |
Citation |
Score |
| 2024 |
Bergh C, Rovšnik U, Howard R, Lindahl E. Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM. Elife. 12. PMID 38289224 DOI: 10.7554/eLife.86016 |
0.333 |
|
| 2021 |
Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations. Life Science Alliance. 4. PMID 34210687 DOI: 10.26508/lsa.202101011 |
0.309 |
|
| 2020 |
Forsberg BO, Aibara S, Howard RJ, Mortezaei N, Lindahl E. Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex. Nature Communications. 11: 4667. PMID 32938938 DOI: 10.1038/S41467-020-18401-Z |
0.307 |
|
| 2020 |
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. PMID 32879488 DOI: 10.1038/S41586-020-2654-5 |
0.321 |
|
| 2020 |
Grottesi A, Bešker N, Emerson A, Manelfi C, Beccari AR, Frigerio F, Lindahl E, Cerchia C, Talarico C. Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations. International Journal of Molecular Sciences. 21. PMID 32731361 DOI: 10.3390/Ijms21155346 |
0.318 |
|
| 2020 |
Hu H, Howard RJ, Bastolla U, Lindahl E, Delarue M. Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482881 DOI: 10.1073/Pnas.1922701117 |
0.417 |
|
| 2020 |
Howard RJ, Zhuang Y, Heusser SA, Bergh CC, Rovsnik U, Orellana L, Lindahl E. Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels Biophysical Journal. 118: 584a. DOI: 10.1016/J.Bpj.2019.11.3169 |
0.37 |
|
| 2020 |
Rovsnik U, Lim V, Blau C, Howard RJ, Lindahl E. Cryo-EM Structure Determination and Model Fitting of the Proton-Gated Ligand-Gated Ion Channel glic at Multiple pH States Biophysical Journal. 118: 581a-582a. DOI: 10.1016/J.Bpj.2019.11.3155 |
0.375 |
|
| 2020 |
Bergh C, Orellana L, Heusser SA, Howard RJ, Lindahl E. Mapping pH-Dependent State Transitions of a Pentameric Ligand-gated Ion Channel through Markov State Modeling Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1160 |
0.328 |
|
| 2019 |
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE. Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor. Neuron. PMID 31488329 DOI: 10.1016/J.Bpj.2019.11.3177 |
0.331 |
|
| 2019 |
Orellana L, Thorne AH, Lema R, Gustavsson J, Parisian AD, Hospital A, Cordeiro TN, Bernadó P, Scott AM, Brun-Heath I, Lindahl E, Cavenee WK, Furnari FB, Orozco M. Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope. Proceedings of the National Academy of Sciences of the United States of America. PMID 31028138 DOI: 10.1073/Pnas.1821442116 |
0.315 |
|
| 2019 |
Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, et al. Structure of the human ClC-1 chloride channel. Plos Biology. 17: e3000218. PMID 31022181 DOI: 10.1371/Journal.Pbio.3000218 |
0.387 |
|
| 2019 |
Orellana L, Gustavsson J, Bergh C, Yoluk O, Lindahl E. eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces. Bioinformatics (Oxford, England). PMID 30838394 DOI: 10.1093/Bioinformatics/Btz104 |
0.311 |
|
| 2019 |
Rovsnik U, Howard R, Forsberg B, Carroni M, Lindahl E. Characterizing Functional States of a Model Ligand-Gated Ion Channel by Cryo-Electron Microscopy Biophysical Journal. 116: 160a. DOI: 10.1016/J.Bpj.2018.11.885 |
0.356 |
|
| 2019 |
Lycksell M, Johansen NT, Howard RJ, Arleth L, Lindahl E. Probing Structural States of a Pentameric Ligand-Gated Ion Channel with Small Angle Neutron Scattering Biophysical Journal. 116: 36a-37a. DOI: 10.1016/J.Bpj.2018.11.241 |
0.358 |
|
| 2019 |
Delarue MH, Hu H, Howard RJ, Rovsnik U, Hlioui S, Lindahl E. Structural Studies of the Gating Mechanism in a Pentameric Ligand-Gated Ion Channel Containing Two Additional N-Terminal Periplasmic Domains Biophysical Journal. 116: 396a. DOI: 10.1016/J.Bpj.2018.11.2140 |
0.379 |
|
| 2019 |
Bergh CC, Orellana L, Howard RJ, Lindahl E. Understanding the Conformational Dynamics of a Pentameric Ligand-Gated Ion Channel through Markov State Modeling Biophysical Journal. 116: 395a-396a. DOI: 10.1016/J.Bpj.2018.11.2138 |
0.393 |
|
| 2019 |
Howard RJ, Zhuang Y, Nakamura S, Lycksell M, Kiik H, Rovšnik U, Bergh C, Heusser SA, Orellana L, Lindahl E. Allosteric Modulation via Transmembrane Interfaces in a Pentameric Ligand-Gated Ion Channel Biophysical Journal. 116: 245a-246a. DOI: 10.1016/J.Bpj.2018.11.1344 |
0.369 |
|
| 2018 |
Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity. Proceedings of the National Academy of Sciences of the United States of America. PMID 30275330 DOI: 10.1016/J.Bpj.2018.11.2137 |
0.426 |
|
| 2018 |
Kimanius D, Lindahl E, Andersson M. Uptake dynamics in the Lactose permease (LacY) membrane protein transporter. Scientific Reports. 8: 14324. PMID 30254312 DOI: 10.1038/S41598-018-32624-7 |
0.342 |
|
| 2018 |
Kasimova MA, Lindahl E, Delemotte L. Determining the molecular basis of voltage sensitivity in membrane proteins. The Journal of General Physiology. PMID 30150239 DOI: 10.1085/Jgp.201812086 |
0.339 |
|
| 2018 |
Perez Boerema A, Aibara S, Paul B, Tobiasson V, Kimanius D, Forsberg BO, Wallden K, Lindahl E, Amunts A. Publisher Correction: Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor. Nature Plants. PMID 30038411 DOI: 10.1038/S41477-018-0203-0 |
0.607 |
|
| 2018 |
Lundborg M, Narangifard A, Wennberg CL, Lindahl E, Daneholt B, Norlén L. Human Skin Barrier Structure and Function Analyzed by Cryo-EM and Molecular Dynamics Simulation. Journal of Structural Biology. PMID 29702212 DOI: 10.1016/J.Jsb.2018.04.005 |
0.335 |
|
| 2018 |
Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels. Cell Reports. 23: 993-1004. PMID 29694907 DOI: 10.1016/J.Celrep.2018.03.108 |
0.421 |
|
| 2018 |
Boerema AP, Aibara S, Paul B, Tobiasson V, Kimanius D, Forsberg BO, Wallden K, Lindahl E, Amunts A. Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor. Nature Plants. 4: 212-217. PMID 29610536 DOI: 10.2210/Pdb6Eri/Pdb |
0.654 |
|
| 2018 |
Wennberg CL, Narangifard A, Lundborg M, Norlén L, Lindahl E. Structural Transitions in Ceramide Cubic Phases during Formation of the Human Skin Barrier. Biophysical Journal. 114: 1116-1127. PMID 29539398 DOI: 10.1016/J.Bpj.2017.12.039 |
0.3 |
|
| 2018 |
Howard RJ, Heusser SA, Zhuang Y, Lycksell M, Klement G, Orellana L, Lindahl E. Alcohol Modulation Via Allosteric Transmembrane Sites In Pentameric Ligand-Gated Ion Channels Alcoholism: Clinical and Experimental Research. 42. DOI: 10.1111/Acer.13834 |
0.348 |
|
| 2018 |
Heusser SA, Lycksell M, Wang X, Howard RJ, Lindahl E. Flexibility of a Transmembrane Helix Underlies Dramatic Reversal of Net Anesthetic Effects in a Pentameric Ligand-Gated Ion Channel Biophysical Journal. 114: 488a-489a. DOI: 10.1016/J.Bpj.2017.11.2680 |
0.383 |
|
| 2018 |
Lycksell M, Heusser SA, Howard RJ, Lindahl E. Expansion of a Transmembrane Cavity Facilitates Anesthetic Potentiation of a Pentameric Ligand Gated Ion Channel Biophysical Journal. 114: 299a. DOI: 10.1016/J.Bpj.2017.11.1707 |
0.37 |
|
| 2018 |
Howard RJ, Fourati Z, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Structural Details of an Allosteric Mechanism for Bimodal Anesthetic Modulation of Pentameric Ligand-Gated Ion Channels Biophysical Journal. 114: 204a. DOI: 10.1016/J.Bpj.2017.11.1137 |
0.392 |
|
| 2017 |
Forsberg BO, Aibara S, Kimanius D, Paul B, Lindahl E, Amunts A. Cryo-EM reconstruction of the chlororibosome to 3.2 Å resolution within 24 h. Iucrj. 4: 723-727. PMID 29123673 DOI: 10.1107/S205225251701226X |
0.617 |
|
| 2017 |
Ottosson NE, Silverå Ejneby M, Wu X, Yazdi S, Konradsson P, Lindahl E, Elinder F. A drug pocket at the lipid bilayer-potassium channel interface. Science Advances. 3: e1701099. PMID 29075666 DOI: 10.1126/Sciadv.1701099 |
0.384 |
|
| 2017 |
Kimanius D, White S, Lindahl E, Kaback R, Andersson M. Uptake Dynamics in the LacY Membrane Protein Transporter Biophysical Journal. 112: 128a. DOI: 10.1016/J.Bpj.2016.11.715 |
0.355 |
|
| 2017 |
Heusser SA, Howard RJ, Fourati Z, Delarue M, Lindahl E. Structural and Functional Evidence for Multi-Site Allostery Mediated by General Anesthetics in a Model Ligand-Gated Ion Channel Biophysical Journal. 112: 554a. DOI: 10.1016/J.Bpj.2016.11.2990 |
0.42 |
|
| 2017 |
Howard RJ, Heusser SA, Yoluk Ö, Snow O, Klement G, Mola AR, MD Ruel T, Lindahl E. Transmembrane Structural Determinants of Alcohol Binding and Modulation in a Model Ligand-Gated Ion Channel Biophysical Journal. 112: 554a. DOI: 10.1016/J.Bpj.2016.11.2988 |
0.379 |
|
| 2017 |
Ottosson N, Silverå Ejneby M, Wu X, Yazdi S, Konradsson P, Lindahl E, Elinder F. Drug Interaction at the Lipid Bilayer-Potassium Channel Interface Biophysical Journal. 112: 40a. DOI: 10.1016/J.Bpj.2016.11.253 |
0.378 |
|
| 2016 |
Grønberg C, Sitsel O, Lindahl E, Gourdon P, Andersson M. Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport. Biophysical Journal. 111: 2417-2429. PMID 27926843 DOI: 10.1016/J.Bpj.2016.10.020 |
0.335 |
|
| 2016 |
Kimanius D, Forsberg BO, Scheres SH, Lindahl E. Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2. Elife. 5. PMID 27845625 DOI: 10.7554/Elife.18722 |
0.315 |
|
| 2016 |
Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C. Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine. Proceedings of the National Academy of Sciences of the United States of America. 113: E6696-E6703. PMID 27791038 DOI: 10.1073/Pnas.1603101113 |
0.381 |
|
| 2016 |
Öjemalm K, Higuchi T, Lara P, Lindahl E, Suga H, von Heijne G. Energetics of side-chain snorkeling in transmembrane helices probed by nonproteinogenic amino acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601675 DOI: 10.1073/Pnas.1606776113 |
0.302 |
|
| 2016 |
Orellana L, Yoluk O, Carrillo O, Orozco M, Lindahl E. Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations. Nature Communications. 7: 12575. PMID 27578633 DOI: 10.1038/Ncomms12575 |
0.359 |
|
| 2016 |
Conti L, Renhorn J, Gabrielsson A, Turesson F, Liin SI, Lindahl E, Elinder F. Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation. Scientific Reports. 6: 27562. PMID 27278891 DOI: 10.1038/Srep27562 |
0.344 |
|
| 2016 |
Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ. Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel. Journal of Neurochemistry. PMID 27102368 DOI: 10.1111/Jnc.13644 |
0.427 |
|
| 2016 |
Yazdi S, Stein M, Elinder F, Andersson M, Lindahl E. The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel. Plos Computational Biology. 12: e1004704. PMID 26751683 DOI: 10.1371/Journal.Pcbi.1004704 |
0.402 |
|
| 2016 |
Forsberg BO, Kimanius D, Lindahl E. Higher Resolution with the Same Data - Tuning cryo-EM Refinement in Relion Biophysical Journal. 110: 157a. DOI: 10.1016/J.Bpj.2015.11.880 |
0.302 |
|
| 2016 |
Blau C, Lenner N, Kutzner C, Grubmuller H, Lindahl E. From CRYO-EM Densities to Atom Coordinates and Ensembles with Bayes Approach Biophysical Journal. 110: 156a-157a. DOI: 10.1016/J.Bpj.2015.11.878 |
0.329 |
|
| 2016 |
Liin S, Gabrielsson A, Elinder F, Lindahl E. The Molecular Mechanism of the Dual Spider Toxin Effect on Voltage Gated K+ Channels Biophysical Journal. 110: 107a. DOI: 10.1016/J.Bpj.2015.11.632 |
0.373 |
|
| 2016 |
Conti L, Renhorn J, Gabrielsson A, Turesson F, Liin S, Lindahl E, Elinder F. A Reciprocal Voltage Sensor-To-Pore Coupling in C-Type Inactivation Biophysical Journal. 110: 104a. DOI: 10.1016/J.Bpj.2015.11.620 |
0.328 |
|
| 2016 |
Orellana L, Yoluk O, Orozco M, Lindahl E. Revealing the Mechanism for Conformational Changes from Structurally Rich Ensembles Biophysical Journal. 110: 54a. DOI: 10.1016/J.Bpj.2015.11.358 |
0.395 |
|
| 2016 |
Yoluk O, Orellana L, Bertaccini EJ, Trudell JR, Lindahl E. Principal Components from Ligand-Gated Ion Channel Structures Enable Ensemble Studies of Microsecond-Scale Transitions Biophysical Journal. 110: 454. DOI: 10.1016/J.Bpj.2015.11.2433 |
0.38 |
|
| 2015 |
Wennberg CL, Murtola T, Páll S, Abraham MJ, Hess B, Lindahl E. Direct-Space Corrections Enable Fast and Accurate Lorentz-Berthelot Combination Rule Lennard-Jones Lattice Summation. Journal of Chemical Theory and Computation. 11: 5737-46. PMID 26587968 DOI: 10.1021/Acs.Jctc.5B00726 |
0.301 |
|
| 2015 |
Kimanius D, Pettersson I, Schluckebier G, Lindahl E, Andersson M. SAXS-Guided Metadynamics. Journal of Chemical Theory and Computation. 11: 3491-8. PMID 26575782 DOI: 10.1021/Acs.Jctc.5B00299 |
0.332 |
|
| 2015 |
Yoluk Ö, Lindahl E, Andersson M. Conformational gating dynamics in the GluCl anion-selective chloride channel. Acs Chemical Neuroscience. 6: 1459-67. PMID 25992588 DOI: 10.1021/Acschemneuro.5B00111 |
0.423 |
|
| 2015 |
Voigt TB, Heusser S, Klement G, Pouya, I, Mola AR, Ruel TMD, Trudell JR, Lindahl E, Howard RJ. P-54PHYSICOCHEMICAL DETERMINANTS OF ALCOHOL BINDING IN A MODEL LIGAND-GATED ION CHANNEL Alcohol and Alcoholism. 50: i59.1-i59. DOI: 10.1093/Alcalc/Agv080.54 |
0.387 |
|
| 2015 |
Heusser SA, Yoluk O, Lindahl E. Exploring the Gating Pathway in an Eukaryotic Ligand-Gated Ion Channel Biophysical Journal. 108: 433a. DOI: 10.1016/J.Bpj.2014.11.2365 |
0.41 |
|
| 2015 |
Yoluk Ö, Heusser S, Pouya I, Howard R, Klement G, Lindahl E. Opening and Selectivity of the Glic Ligand-Gated Ion Channel can be Tuned by Mutation of Hydrophobic Residues in the Pore Biophysical Journal. 108: 431a. DOI: 10.1016/J.Bpj.2014.11.2357 |
0.363 |
|
| 2015 |
Yoluk O, Heusser S, Andersson M, Orellana L, Lindahl E. Gating Ritual: Simulations of Gating in Glutamate-Gated Chloride Channel Biophysical Journal. 108: 431a. DOI: 10.1016/J.Bpj.2014.11.2355 |
0.428 |
|
| 2015 |
Andersson M, Lindahl E, White SH, Kaback RH. The Molecular Basis for Substrate Specificity in Lactose Permease Biophysical Journal. 108: 309a. DOI: 10.1016/J.Bpj.2014.11.1680 |
0.369 |
|
| 2014 |
Lundborg M, Apostolov R, Spångberg D, Gärdenäs A, van der Spoel D, Lindahl E. An efficient and extensible format, library, and API for binary trajectory data from molecular simulations. Journal of Computational Chemistry. 35: 260-9. PMID 24258850 DOI: 10.1002/Jcc.23495 |
0.312 |
|
| 2014 |
Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcoholism, Clinical and Experimental Research. 38: 595-603. PMID 24164436 DOI: 10.1111/Acer.12283 |
0.409 |
|
| 2014 |
Yazdi S, Andersson M, Elinder F, Stein M, Lindahl E. Molecular Characterization of the Binding of Polyunsaturated Fatty Acids to a Voltage-Gated Potassium Channel Biophysical Journal. 106: 739a. DOI: 10.1016/J.Bpj.2013.11.4071 |
0.341 |
|
| 2014 |
Gabrielsson A, Liin S, Elinder F, Lindahl E. Binding Structure & Dynamics for Toxins Modifying the Gating Mechanism of Kv Channels Biophysical Journal. 106: 738a. DOI: 10.1016/J.Bpj.2013.11.4066 |
0.44 |
|
| 2014 |
Yoluk O, Riederer EA, Andersson M, Klement G, Trudell JR, Bertaccini EJ, Howard RJ, Lindahl E. Contribution of Structural Elements to Activation and Allosteric Modulation in an Anionic Ligand-Gated Ion Channel Biophysical Journal. 106: 547a. DOI: 10.1016/J.Bpj.2013.11.3046 |
0.375 |
|
| 2014 |
Riederer E, Yoluk O, Trudell J, Lindahl E, Harris A, Howard R. Alcohol Modulation of a Eukaryotic Ligand-Gated Ion Channel of Known Structure Biophysical Journal. 106: 545a. DOI: 10.1016/J.Bpj.2013.11.3034 |
0.337 |
|
| 2014 |
Pouya I, Klement G, Murail S, Kasson P, Yoluk Ö, Lindahl E. Altering the Open vs. Closed State Balance of the GLIC Ligand-Gated Ion Channel through Mutagenesis Enables Molecular Simulation of the Reversible Gating Process Biophysical Journal. 106: 343a. DOI: 10.1016/J.Bpj.2013.11.1959 |
0.455 |
|
| 2014 |
Klement G, Pouya I, Yoluk Ö, Howard R, Lindahl E. Ligand-Gated Ion Channel Gating Kinetics and the Opening/Closing Mechanism are Sensitive to Mutations Altering the Hydrophobicity of the Ion Conduction Pore Biophysical Journal. 106: 343a. DOI: 10.1016/J.Bpj.2013.11.1958 |
0.405 |
|
| 2014 |
Arrar M, Pouya I, McCammon JA, Lindahl E. Molecular Insights into the Gating Mechanism of GLIC, a Prokaryotic Ligand-Gated Ion Channel Biophysical Journal. 106: 342a. DOI: 10.1016/J.Bpj.2013.11.1957 |
0.412 |
|
| 2014 |
Larsson P, Pouya I, Lindahl E. From Side Chains Rattling on Picoseconds to Ensemble Simulations of Protein Folding Israel Journal of Chemistry. 54: 1274-1285. DOI: 10.1002/Ijch.201400020 |
0.318 |
|
| 2013 |
Wennberg CL, Murtola T, Hess B, Lindahl E. Lennard-Jones Lattice Summation in Bilayer Simulations Has Critical Effects on Surface Tension and Lipid Properties. Journal of Chemical Theory and Computation. 9: 3527-37. PMID 26584109 DOI: 10.1021/Ct400140N |
0.33 |
|
| 2013 |
Santacruz-Perez C, Pegos VR, Honorato RV, Verli H, Lindahl E, Barbosa JA, Balan A. A specific interdomain interaction preserves the structural and binding properties of the ModA protein from the phytopathogen Xanthomonas citri domain interaction and transport in ModA. Archives of Biochemistry and Biophysics. 539: 20-30. PMID 24035743 DOI: 10.1016/J.Abb.2013.09.003 |
0.371 |
|
| 2013 |
Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA. Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels. Molecular Pharmacology. 84: 670-8. PMID 23950219 DOI: 10.1124/Mol.113.087692 |
0.342 |
|
| 2013 |
Yoluk O, Brömstrup T, Bertaccini EJ, Trudell JR, Lindahl E. Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin. Biophysical Journal. 105: 640-7. PMID 23931312 DOI: 10.1016/J.Bpj.2013.06.037 |
0.436 |
|
| 2013 |
Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E. Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure (London, England : 1993). 21: 1307-16. PMID 23891290 DOI: 10.1016/J.Str.2013.06.018 |
0.342 |
|
| 2013 |
Pronk S, Páll S, Schulz R, Larsson P, Bjelkmar P, Apostolov R, Shirts MR, Smith JC, Kasson PM, van der Spoel D, Hess B, Lindahl E. GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit. Bioinformatics (Oxford, England). 29: 845-54. PMID 23407358 DOI: 10.1093/Bioinformatics/Btt055 |
0.348 |
|
| 2013 |
Schwaiger CS, Liin SI, Elinder F, Lindahl E. The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects. Biophysical Journal. 104: 75-84. PMID 23332060 DOI: 10.1016/J.Bpj.2012.11.3827 |
0.369 |
|
| 2013 |
Kasson PM, Hess B, Lindahl E. Probing microscopic material properties inside simulated membranes through spatially resolved three-dimensional local pressure fields and surface tensions. Chemistry and Physics of Lipids. 169: 106-12. PMID 23318532 DOI: 10.1016/J.Chemphyslip.2013.01.001 |
0.352 |
|
| 2013 |
Paulsen PA, Jurkowski W, Apostolov R, Lindahl E, Nissen P, Poulsen H. The C-terminal cavity of the Na,K-ATPase analyzed by docking and electrophysiology. Molecular Membrane Biology. 30: 195-205. PMID 22913437 DOI: 10.3109/09687688.2012.713520 |
0.302 |
|
| 2013 |
Henrion U, Schwaiger CS, Börjesson SI, Elinder F, Lindahl E. Tracking a Voltage-Sensor Cycle with Models of Intermediate States from Metal-Ion Bridge Constraints Biophysical Journal. 104: 124a-125a. DOI: 10.1016/J.Bpj.2012.11.717 |
0.393 |
|
| 2013 |
Kasson PM, Lindahl E. Local Stresses in Fusing Membranes from Molecular Simulation Biophysical Journal. 104: 92a. DOI: 10.1016/J.Bpj.2012.11.549 |
0.308 |
|
| 2013 |
Yoluk O, Andersson M, Lindahl E. Improved Comparative Models of Human Gabaar Ligand-Gated Ion Channels Based on Structural Dynamics of GluCl Biophysical Journal. 104: 638a. DOI: 10.1016/J.Bpj.2012.11.3521 |
0.395 |
|
| 2013 |
Howard RJ, Sauguet L, Broemstrup T, Murail S, Lee US, Horani S, Trudell JR, Corringer P, Lindahl E, Delarue M, Harris RA. Alcohol and Anesthetic Binding to Pentameric Ligand-Gated Ion Channels Revealed in a Prokaryotic Model System Biophysical Journal. 104: 635a-636a. DOI: 10.1016/J.Bpj.2012.11.3512 |
0.355 |
|
| 2013 |
Pouya I, Pronk S, Rotskoff G, Kasson PM, Lindahl E. Ligand-Gated Ion Channel Opening and Closing Mechanism from Molecular Simulations Biophysical Journal. 104: 271a. DOI: 10.1016/J.Bpj.2012.11.1518 |
0.435 |
|
| 2012 |
Lindahl E. Unraveling the strokes of ion channel molecular machines in computers. Proceedings of the National Academy of Sciences of the United States of America. 109: 21186-7. PMID 23236147 DOI: 10.1073/Pnas.1218763110 |
0.368 |
|
| 2012 |
Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B. An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. The Journal of General Physiology. 140: 587-94. PMID 23183694 DOI: 10.1085/Jgp.201210873 |
0.416 |
|
| 2012 |
Schwaiger CS, Börjesson SI, Hess B, Wallner B, Elinder F, Lindahl E. The free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain. Plos One. 7: e45880. PMID 23094020 DOI: 10.1371/Journal.Pone.0045880 |
0.365 |
|
| 2012 |
Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E. Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. Plos Computational Biology. 8: e1002710. PMID 23055913 DOI: 10.1371/Journal.Pcbi.1002710 |
0.315 |
|
| 2012 |
Henrion U, Renhorn J, Börjesson SI, Nelson EM, Schwaiger CS, Bjelkmar P, Wallner B, Lindahl E, Elinder F. Tracking a complete voltage-sensor cycle with metal-ion bridges. Proceedings of the National Academy of Sciences of the United States of America. 109: 8552-7. PMID 22538811 DOI: 10.1073/Pnas.1116938109 |
0.399 |
|
| 2012 |
Wacker SJ, Jurkowski W, Simmons KJ, Fishwick CW, Johnson AP, Madge D, Lindahl E, Rolland JF, de Groot BL. Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp. Chemmedchem. 7: 1775-83. PMID 22473914 DOI: 10.1002/Cmdc.201100600 |
0.321 |
|
| 2012 |
Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, Brügger B. Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature. 481: 525-9. PMID 22230960 DOI: 10.1038/Nature10742 |
0.345 |
|
| 2012 |
Murail S, Howard RJ, Trudell JR, Bertaccini E, Lindahl E. Tracing the Closing of a Ligand-Gated Ion Channel in Atomic Detail: An Unconstrained Four-Microsecond Simulation of GLIC Leads to a Closed State Remarkably Similar to ELIC Biophysical Journal. 102: 113a-114a. DOI: 10.1016/J.Bpj.2011.11.639 |
0.389 |
|
| 2012 |
Yoluk O, Murail S, Lindahl E. Simulations of Subunit Interactions in the C. Elegans GluCl Ligand-Gated Ion Channel Biophysical Journal. 102: 472a. DOI: 10.1016/J.Bpj.2011.11.2587 |
0.398 |
|
| 2012 |
Schwaiger CS, Börjesson SI, Hess B, Elinder F, Lindahl E. Phe233 in the Voltage-Sensor is Rate Limiting for Channel Closure but not for the Opening Biophysical Journal. 102: 13a. DOI: 10.1016/J.Bpj.2011.11.096 |
0.393 |
|
| 2011 |
Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 12149-54. PMID 21730162 DOI: 10.1073/Pnas.1104480108 |
0.33 |
|
| 2011 |
Murail S, Wallner B, Trudell JR, Bertaccini E, Lindahl E. Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. Biophysical Journal. 100: 1642-50. PMID 21463577 DOI: 10.1016/J.Bpj.2011.02.032 |
0.375 |
|
| 2011 |
Schwaiger CS, Bjelkmar P, Hess B, Lindahl E. 3₁₀-helix conformation facilitates the transition of a voltage sensor S4 segment toward the down state. Biophysical Journal. 100: 1446-54. PMID 21402026 DOI: 10.1016/J.Bpj.2011.02.003 |
0.335 |
|
| 2011 |
Kasson PM, Lindahl E, Pande VS. Water ordering at membrane interfaces controls fusion dynamics. Journal of the American Chemical Society. 133: 3812-5. PMID 21351772 DOI: 10.1021/Ja200310D |
0.32 |
|
| 2011 |
Larsson P, Hess B, Lindahl E. Algorithm improvements for molecular dynamics simulations Wiley Interdisciplinary Reviews: Computational Molecular Science. 1: 93-108. DOI: 10.1002/Wcms.3 |
0.312 |
|
| 2010 |
Bjelkmar P, Larsson P, Cuendet MA, Hess B, Lindahl E. Implementation of the CHARMM Force Field in GROMACS: Analysis of Protein Stability Effects from Correction Maps, Virtual Interaction Sites, and Water Models. Journal of Chemical Theory and Computation. 6: 459-66. PMID 26617301 DOI: 10.1021/Ct900549R |
0.323 |
|
| 2010 |
Bertaccini EJ, Trudell JR, Lindahl E. Normal mode gating motions of a ligand-gated ion channel persist in a fully hydrated lipid bilayer model. Acs Chemical Neuroscience. 1: 552-8. PMID 22816018 DOI: 10.1021/Cn100026T |
0.386 |
|
| 2010 |
Bertaccini EJ, Wallner B, Trudell JR, Lindahl E. Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. Journal of Chemical Information and Modeling. 50: 2248-55. PMID 21117677 DOI: 10.1021/Ci100266C |
0.411 |
|
| 2010 |
Ray A, Lindahl E, Wallner B. Model quality assessment for membrane proteins. Bioinformatics (Oxford, England). 26: 3067-74. PMID 20947525 DOI: 10.1093/Bioinformatics/Btq581 |
0.329 |
|
| 2010 |
Larsson P, Lindahl E. A high-performance parallel-generalized Born implementation enabled by tabulated interaction rescaling. Journal of Computational Chemistry. 31: 2593-600. PMID 20740558 DOI: 10.1002/Jcc.21552 |
0.325 |
|
| 2010 |
Kasson PM, Lindahl E, Pande VS. Atomic-resolution simulations predict a transition state for vesicle fusion defined by contact of a few lipid tails. Plos Computational Biology. 6: e1000829. PMID 20585620 DOI: 10.1371/Journal.Pcbi.1000829 |
0.342 |
|
| 2010 |
Niemelä PS, Miettinen MS, Monticelli L, Hammaren H, Bjelkmar P, Murtola T, Lindahl E, Vattulainen I. Membrane proteins diffuse as dynamic complexes with lipids. Journal of the American Chemical Society. 132: 7574-5. PMID 20469857 DOI: 10.1021/Ja101481B |
0.307 |
|
| 2010 |
Murail S, Wallner B, Trudell JR, Bertaccini E, Lindahl E. Microsecond Simulations Show that Ethanol Binds between Subunits and Stabilizes the Open Form of a Glycine Receptor Model Biophysical Journal. 98: 704a-705a. DOI: 10.1016/J.Bpj.2009.12.3865 |
0.38 |
|
| 2010 |
Kasson P, Lindahl E, Pande V. Atomic-Resolution Simulations Yield New Insight into Vesicle Fusion and Fusion Protein Mechanisms Biophysical Journal. 98: 616a. DOI: 10.1016/J.Bpj.2009.12.3363 |
0.34 |
|
| 2010 |
Schwaiger CS, Bjelkmar P, Hess B, Lindahl E. Structural Transition from Alpha- to 3_10-Helix Reduces the Free Energy Required for S4 Translation in Kv1.2/2.1 Voltage Sensors, and F233 Appears to Responsible for the Gating Barrier Biophysical Journal. 98: 520a. DOI: 10.1016/J.Bpj.2009.12.2827 |
0.372 |
|
| 2010 |
Lindahl E, Schwaiger C, Bjelkmar P. Microsecond Simulations Indicate 3_10 Helix Transition Facilitates Translation of the S4 Segment of Kv1.2 and Suggest a Hydrophobic Gating Barrier Biophysical Journal. 98: 520a. DOI: 10.1016/J.Bpj.2009.12.2826 |
0.397 |
|
| 2009 |
Johansson AC, Lindahl E. Protein contents in biological membranes can explain abnormal solvation of charged and polar residues. Proceedings of the National Academy of Sciences of the United States of America. 106: 15684-9. PMID 19805218 DOI: 10.1073/Pnas.0905394106 |
0.366 |
|
| 2009 |
Johansson AC, Lindahl E. The role of lipid composition for insertion and stabilization of amino acids in membranes. The Journal of Chemical Physics. 130: 185101. PMID 19449954 DOI: 10.1063/1.3129863 |
0.333 |
|
| 2009 |
Bjelkmar P, Niemelä PS, Vattulainen I, Lindahl E. Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel. Plos Computational Biology. 5: e1000289. PMID 19229308 DOI: 10.1371/Journal.Pcbi.1000289 |
0.454 |
|
| 2009 |
Johansson AC, Lindahl E. Titratable amino acid solvation in lipid membranes as a function of protonation state. The Journal of Physical Chemistry. B. 113: 245-53. PMID 19118487 DOI: 10.1021/Jp8048873 |
0.369 |
|
| 2008 |
Hess B, Kutzner C, van der Spoel D, Lindahl E. GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Journal of Chemical Theory and Computation. 4: 435-47. PMID 26620784 DOI: 10.1021/Ct700301Q |
0.303 |
|
| 2008 |
Bernsel A, Viklund H, Falk J, Lindahl E, von Heijne G, Elofsson A. Prediction of membrane-protein topology from first principles. Proceedings of the National Academy of Sciences of the United States of America. 105: 7177-81. PMID 18477697 DOI: 10.1073/Pnas.0711151105 |
0.317 |
|
| 2008 |
Lindahl E, Sansom MS. Membrane proteins: molecular dynamics simulations. Current Opinion in Structural Biology. 18: 425-31. PMID 18406600 DOI: 10.1016/J.Sbi.2008.02.003 |
0.415 |
|
| 2008 |
Bertaccini EJ, Lindahl E, Sixma T, Trudell JR. Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. Journal of Chemical Information and Modeling. 48: 855-60. PMID 18348519 DOI: 10.1021/Ci700456S |
0.368 |
|
| 2008 |
Johansson AC, Lindahl E. Position-resolved free energy of solvation for amino acids in lipid membranes from molecular dynamics simulations. Proteins. 70: 1332-44. PMID 17876818 DOI: 10.1002/Prot.21629 |
0.359 |
|
| 2007 |
Bertaccini EJ, Trudell JR, Lindahl E. Normal-mode analysis of the glycine alpha1 receptor by three separate methods. Journal of Chemical Information and Modeling. 47: 1572-9. PMID 17602605 DOI: 10.1021/Ci600566J |
0.343 |
|
| 2006 |
Johansson AC, Lindahl E. Amino-acid solvation structure in transmembrane helices from molecular dynamics simulations. Biophysical Journal. 91: 4450-63. PMID 17012325 DOI: 10.1529/Biophysj.106.092767 |
0.328 |
|
| 2006 |
Lindahl E, Azuara C, Koehl P, Delarue M. NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis. Nucleic Acids Research. 34: W52-6. PMID 16845062 DOI: 10.1093/Nar/Gkl082 |
0.324 |
|
| 2006 |
Azuara C, Lindahl E, Koehl P, Orland H, Delarue M. PDB_Hydro: incorporating dipolar solvents with variable density in the Poisson-Boltzmann treatment of macromolecule electrostatics. Nucleic Acids Research. 34: W38-42. PMID 16845031 DOI: 10.1093/Nar/Gkl072 |
0.349 |
|
| 2005 |
Lindahl E, Delarue M. Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization. Nucleic Acids Research. 33: 4496-506. PMID 16087736 DOI: 10.1093/Nar/Gki730 |
0.318 |
|
| 2004 |
Rhee YM, Sorin EJ, Jayachandran G, Lindahl E, Pande VS. Simulations of the role of water in the protein-folding mechanism. Proceedings of the National Academy of Sciences of the United States of America. 101: 6456-61. PMID 15090647 DOI: 10.1073/Pnas.0307898101 |
0.307 |
|
| 2003 |
Hofsäss C, Lindahl E, Edholm O. Molecular dynamics simulations of phospholipid bilayers with cholesterol. Biophysical Journal. 84: 2192-206. PMID 12668428 DOI: 10.1016/S0006-3495(03)75025-5 |
0.315 |
|
| 2001 |
Marrink SJ, Lindahl E, Edholm O, Mark AE. Simulation of the spontaneous aggregation of phospholipids into bilayers [23] Journal of the American Chemical Society. 123: 8638-8639. PMID 11525689 DOI: 10.1021/Ja0159618 |
0.364 |
|
| 2001 |
Lindahl E, Edholm O. Molecular dynamics simulation of NMR relaxation rates and slow dynamics in lipid bilayers Journal of Chemical Physics. 115: 4938-4950. DOI: 10.1063/1.1389469 |
0.321 |
|
| 2001 |
Lindahl E, Hess B, Spoel Dvd. GROMACS 3.0: a package for molecular simulation and trajectory analysis Journal of Molecular Modeling. 7: 306-317. DOI: 10.1007/S008940100045 |
0.301 |
|
| 2000 |
Lindahl E, Edholm O. Mesoscopic undulations and thickness fluctuations in lipid bilayers from molecular dynamics simulations. Biophysical Journal. 79: 426-33. PMID 10866968 DOI: 10.1016/S0006-3495(00)76304-1 |
0.307 |
|
| 2000 |
Lindahl E, Edholm O. Spatial and energetic-entropic decomposition of surface tension in lipid bilayers from molecular dynamics simulations The Journal of Chemical Physics. 113: 3882-3893. DOI: 10.1063/1.1287423 |
0.31 |
|
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