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Abraham J. Al-Ahmad, Ph.D. - Publications

Affiliations: 
2004-2009 Veterinary Physiology Universität Zürich, Zürich, ZH, Switzerland 
 2009-2011 Molecular & Cellular Medicine Texas A&M Health Science Center, Bryan, TX, United States 
 2011-2014 Chemical & Biological Engineering University of Wisconsin, Madison, Madison, WI 
 2014- Pharmaceutical Sciences Texas Tech University Health Sciences Center 
Area:
Blood-brain barrier, Hypoxia, Stroke, Alzheimer's disease, GLUT1 deficiency syndrome
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30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Al-Ahmad AJ. Human-Induced Pluripotent Stem Cell-Based Model of the Blood-Brain at 10 Years: A Retrospective on Past and Current Disease Models. Handbook of Experimental Pharmacology. PMID 36943490 DOI: 10.1007/164_2023_645  0.418
2023 Noorani B, Chowdhury EA, Alqahtani F, Ahn Y, Nozohouri E, Zoubi S, Patel D, Wood L, Huang J, Siddique MB, Al-Ahmad A, Mehvar R, Bickel U. Effects of Volatile Anesthetics Versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. The Journal of Pharmacology and Experimental Therapeutics. PMID 36828631 DOI: 10.1124/jpet.122.001281  0.438
2022 Pervaiz I, Zahra FT, Mikelis C, Al-Ahmad AJ. An in vitro model of glucose transporter 1 deficiency syndrome at the blood-brain barrier using induced pluripotent stem cells. Journal of Neurochemistry. PMID 35943296 DOI: 10.1111/jnc.15684  0.463
2022 Pervaiz I, Al-Ahmad AJ. In Vitro Models of the Human Blood-Brain Barrier Utilising Human Induced Pluripotent Stem Cells: Opportunities and Challenges. Methods in Molecular Biology (Clifton, N.J.). 2492: 53-72. PMID 35733038 DOI: 10.1007/978-1-0716-2289-6_3  0.569
2022 Raut S, Patel R, Pervaiz I, Al-Ahmad AJ. Abeta peptides disrupt the barrier integrity and glucose metabolism of human induced pluripotent stem cell-derived brain microvascular endothelial cells. Neurotoxicology. 89: 110-120. PMID 35065085 DOI: 10.1016/j.neuro.2022.01.007  0.616
2021 Al-Ahmad AJ, Pervaiz I, Karamyan VT. Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model. Journal of Neuroendocrinology. 33: e12931. PMID 33506602 DOI: 10.1111/jne.12931  0.456
2021 Raut S, Patel R, Al-Ahmad AJ. Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro. Fluids and Barriers of the Cns. 18: 3. PMID 33413468 DOI: 10.1186/s12987-020-00235-y  0.563
2020 Kinarivala N, Morsy A, Patel R, Carmona AV, Sajib MS, Raut S, Mikelis CM, Al-Ahmad A, Trippier PC. An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening. Acs Pharmacology & Translational Science. 3: 931-947. PMID 33073192 DOI: 10.1021/acsptsci.0c00077  0.723
2020 Nozohouri S, Noorani B, Al-Ahmad A, Abbruscato TJ. Estimating Brain Permeability Using In Vitro Blood-Brain Barrier Models. Methods in Molecular Biology (Clifton, N.J.). PMID 32789777 DOI: 10.1007/7651_2020_311  0.577
2019 Albekairi TH, Vaidya B, Patel R, Nozohouri S, Villalba H, Zhang Y, Lee YS, Al-Ahmad A, Abbruscato TJ. Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP). Pharmaceutics. 11. PMID 31509975 DOI: 10.3390/Pharmaceutics11090467  0.679
2019 Page S, Raut S, Al-Ahmad A. Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway. Neuromolecular Medicine. PMID 30911877 DOI: 10.1007/S12017-019-08531-Z  0.761
2018 Martinez A, Al-Ahmad AJ. Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicology Letters. PMID 30605748 DOI: 10.1016/J.Toxlet.2018.12.013  0.564
2018 Page S, Patel R, Raut S, Al-Ahmad A. Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 30593893 DOI: 10.1016/J.Bbadis.2018.12.009  0.79
2018 Patel R, Hossain MA, German N, Al-Ahmad AJ. Gliotoxin penetrates and impairs the integrity of the human blood-brain barrier in vitro. Mycotoxin Research. PMID 30006720 DOI: 10.1007/S12550-018-0320-7  0.697
2018 Al-Ahmad AJ, Patel R, Palecek SP, Shusta EV. Hyaluronan impairs the barrier integrity of brain microvascular endothelial cell through a CD44-dependent pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18767748. PMID 29589805 DOI: 10.1177/0271678X18767748  0.715
2017 Kinarivala N, Patel R, Boustany RM, Al-Ahmad AJ, Trippier PC. Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-cell lymphoma 2 (Bcl-2). Journal of Medicinal Chemistry. PMID 29110485 DOI: 10.1021/Acs.Jmedchem.7B01199  0.71
2017 Al-Ahmad AJ. Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells. American Journal of Physiology. Cell Physiology. 313: C421-C429. PMID 28993322 DOI: 10.1152/Ajpcell.00116.2017  0.454
2017 Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Garcia VJ, Ho R, Yucer N, Qian T, Lim RG, Wu J, Thompson LM, Spivia WR, Chen Z, et al. Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier. Cell Stem Cell. PMID 28526555 DOI: 10.1016/J.Stem.2017.04.002  0.734
2016 Page S, Munsell A, Al-Ahmad AJ. Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells. Fluids and Barriers of the Cns. 13: 16. PMID 27724968 DOI: 10.1186/S12987-016-0042-1  0.732
2016 Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Analysis of Cancer-targeting Alkylphosphocholine Analog Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Molecular Pharmaceutics. PMID 27421304 DOI: 10.1021/Acs.Molpharmaceut.6B00441  0.718
2015 Clark P, Al-Ahmad A, Qian T, Zhang R, Jeffery J, Wilson H, Palecek S, Weichert J, Shusta E, Kuo J. DDEL-05DIFFERENTIAL BLOOD-BRAIN BARRIER (BBB) PERMEABILITY OF ALKYLPHOSPHOCHOLINE (APC) ANALOGS ANALYZED USING AN IN VITRO PLURIPOTENT STEM CELL-DERIVED BRAIN MICROVASCULAR ENDOTHELIAL CELL SYSTEM Neuro-Oncology. 17: v74.1-v74. DOI: 10.1093/Neuonc/Nov212.05  0.72
2015 Lian X, Bao X, Al-Ahmad A, Liu J, Wu Y, Dong W, Dunn KK, Shusta EV, Palecek SP. Erratum: Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling (Stem Cell Reports (2014) 3 (804-816)) Stem Cell Reports. 4. DOI: 10.1016/J.Stemcr.2014.12.011  0.658
2014 Lian X, Bao X, Al-Ahmad A, Liu J, Wu Y, Dong W, Dunn KK, Shusta EV, Palecek SP. Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling. Stem Cell Reports. 3: 804-16. PMID 25418725 DOI: 10.1016/J.Stemcr.2014.09.005  0.667
2014 Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, Shusta EV. A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Scientific Reports. 4: 4160. PMID 24561821 DOI: 10.1038/Srep04160  0.797
2014 Engelhardt S, Al-Ahmad AJ, Gassmann M, Ogunshola OO. Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism. Journal of Cellular Physiology. 229: 1096-105. PMID 24375098 DOI: 10.1002/Jcp.24544  0.758
2013 Lippmann ES, Al-Ahmad A, Palecek SP, Shusta EV. Modeling the blood-brain barrier using stem cell sources. Fluids and Barriers of the Cns. 10: 2. PMID 23305164 DOI: 10.1186/2045-8118-10-2  0.807
2012 Ogunshola OO, Al-Ahmad A. HIF-1 at the blood-brain barrier: a mediator of permeability? High Altitude Medicine & Biology. 13: 153-61. PMID 22994514 DOI: 10.1089/Ham.2012.1052  0.753
2012 Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, Palecek SP, Shusta EV. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nature Biotechnology. 30: 783-91. PMID 22729031 DOI: 10.1038/Nbt.2247  0.806
2011 Al-Ahmad AJ, Lee B, Saini M, Bix GJ. Perlecan domain V modulates astrogliosis in vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release. Glia. 59: 1822-40. PMID 21850672 DOI: 10.1002/Glia.21227  0.641
2006 Patel R, Al-Ahmad AJ. O2-12-03: MUTATIONS IN PSEN GENES ASSOCIATED WITH FAMILIAL FORM OF ALZHEIMER'S DISEASE DISPLAY AN IMPAIRED BLOOD-BRAIN BARRIER PHENOTYPE IN VITRO Alzheimer's & Dementia. 14: P651-P651. DOI: 10.1016/J.Jalz.2018.06.2708  0.583
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