| Year |
Citation |
Score |
| 2022 |
Ottaviani A, Iacovelli F, Welsch J, Morozzo Della Rocca B, Desideri A, Falconi M, Calcul L, Baker BJ, Fiorani P. Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B. Cells. 11. PMID 36359884 DOI: 10.3390/cells11213486 |
0.45 |
|
| 2022 |
Ottaviani A, Welsch J, Agama K, Pommier Y, Desideri A, Baker BJ, Fiorani P. From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge . Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 1404-1410. PMID 35603503 DOI: 10.1080/14756366.2022.2078320 |
0.45 |
|
| 2021 |
Soren BC, Babu Dasari J, Ottaviani A, Messina B, Andreotti G, Romeo A, Iacovelli F, Falconi M, Desideri A, Fiorani P. In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB. International Journal of Molecular Sciences. 22. PMID 34299074 DOI: 10.3390/ijms22147455 |
0.6 |
|
| 2021 |
Ottaviani A, Iacovelli F, Fiorani P, Desideri A. Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB. International Journal of Molecular Sciences. 22. PMID 33923641 DOI: 10.3390/ijms22084138 |
0.398 |
|
| 2020 |
Soren BC, Dasari JB, Ottaviani A, Iacovelli F, Fiorani P. Topoisomerase IB: a relaxing enzyme for stressed DNA. Cancer Drug Resistance (Alhambra, Calif.). 3: 18-25. PMID 35582040 DOI: 10.20517/cdr.2019.106 |
0.595 |
|
| 2020 |
Dasari JB, Soren BC, Ottaviani A, Tesauro C, Marino S, Messina B, Fiorani P. Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Counterpart Strongly Impairs Enzyme Activity. Reports of Biochemistry & Molecular Biology. 8: 366-375. PMID 32582794 |
0.326 |
|
| 2019 |
Wang Z, D'Annessa I, Tesauro C, Ottaviani A, Soren BC, Dasari JB, Messina B, Thareparambil A, Fiorani P. The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance. Archives of Biochemistry and Biophysics. PMID 30653963 DOI: 10.1016/J.Abb.2019.01.007 |
0.728 |
|
| 2018 |
Wang Z, Ouyang H, Tesauro C, Ottaviani A, He Y, Fiorani P, Xie H, Desideri A, Fu Z. Real-time analysis of cleavage and religation activity of human topoisomerase 1 based on ternary fluorescence resonance energy transfer DNA substrate. Archives of Biochemistry and Biophysics. PMID 29458004 DOI: 10.1016/J.Abb.2018.02.006 |
0.562 |
|
| 2015 |
Zuccaro L, Tesauro C, Kurkina T, Fiorani P, Yu HK, Knudsen BR, Kern K, Desideri A, Balasubramanian K. Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene. Acs Nano. PMID 26445172 DOI: 10.1021/Acsnano.5B05709 |
0.375 |
|
| 2015 |
Wang Z, D'Annessa I, Tesauro C, Croce S, Ottaviani A, Fiorani P, Desideri A. Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation. Biochimica Et Biophysica Acta. 1854: 860-8. PMID 25910424 DOI: 10.1016/J.Bbapap.2015.04.017 |
0.71 |
|
| 2014 |
Tesauro C, Graziani G, Arnò B, Zuccaro L, Muzi A, D'Annessa I, Santori E, Tentori L, Leonetti C, Fiorani P, Desideri A. Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers. Journal of Experimental & Clinical Cancer Research : Cr. 33: 71. PMID 25227992 DOI: 10.1186/S13046-014-0071-Z |
0.627 |
|
| 2013 |
D'Annessa I, Tesauro C, Wang Z, Arnò B, Zuccaro L, Fiorani P, Desideri A. The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation. Biochimica Et Biophysica Acta. 1834: 2712-21. PMID 24096022 DOI: 10.1016/J.Bbapap.2013.09.017 |
0.637 |
|
| 2013 |
Tesauro C, Morozzo della Rocca B, Ottaviani A, Coletta A, Zuccaro L, Arnò B, D'Annessa I, Fiorani P, Desideri A. Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico. Molecular Cancer. 12: 100. PMID 24004603 DOI: 10.1186/1476-4598-12-100 |
0.689 |
|
| 2013 |
Arnò B, D'Annessa I, Tesauro C, Zuccaro L, Ottaviani A, Knudsen B, Fiorani P, Desideri A. Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant. Plos One. 8: e68404. PMID 23844196 DOI: 10.1371/Journal.Pone.0068404 |
0.46 |
|
| 2013 |
Arnò B, Coletta A, Tesauro C, Zuccaro L, Fiorani P, Lentini S, Galloni P, Conte V, Floris B, Desideri A. A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism. Bioscience Reports. 33: e00025. PMID 23368812 DOI: 10.1042/Bsr20120118 |
0.546 |
|
| 2012 |
Juul S, Nielsen CJ, Labouriau R, Roy A, Tesauro C, Jensen PW, Harmsen C, Kristoffersen EL, Chiu YL, Frøhlich R, Fiorani P, Cox-Singh J, Tordrup D, Koch J, Bienvenu AL, et al. Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. Acs Nano. 6: 10676-83. PMID 23121492 DOI: 10.1021/Nn3038594 |
0.304 |
|
| 2012 |
Castelli S, Coletta A, D'Annessa I, Fiorani P, Tesauro C, Desideri A. Interaction between natural compounds and human topoisomerase I. Biological Chemistry. 393: 1327-40. PMID 23109546 DOI: 10.1515/Hsz-2012-0240 |
0.537 |
|
| 2012 |
D'Annessa I, Tesauro C, Fiorani P, Chillemi G, Castelli S, Vassallo O, Capranico G, Desideri A. Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. Journal of Amino Acids. 2012: 206083. PMID 22315664 DOI: 10.1155/2012/206083 |
0.703 |
|
| 2010 |
Tesauro C, Fiorani P, D'Annessa I, Chillemi G, Turchi G, Desideri A. Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I. The Biochemical Journal. 425: 531-9. PMID 19883377 DOI: 10.1042/Bj20091127 |
0.481 |
|
| 2009 |
Fiorani P, Tesauro C, Mancini G, Chillemi G, D'Annessa I, Graziani G, Tentori L, Muzi A, Desideri A. Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Research. 37: 6849-58. PMID 19767617 DOI: 10.1093/Nar/Gkp669 |
0.575 |
|
| 2009 |
Castelli S, Campagna A, Vassallo O, Tesauro C, Fiorani P, Tagliatesta P, Oteri F, Falconi M, Majumder HK, Desideri A. Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin. Archives of Biochemistry and Biophysics. 486: 103-10. PMID 19397888 DOI: 10.1016/J.Abb.2009.04.007 |
0.6 |
|
| 2008 |
Losasso C, Cretaio E, Fiorani P, D'Annessa I, Chillemi G, Benedetti P. A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Research. 36: 5635-44. PMID 18772225 DOI: 10.1093/Nar/Gkn557 |
0.779 |
|
| 2008 |
Chillemi G, D'Annessa I, Fiorani P, Losasso C, Benedetti P, Desideri A. Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Research. 36: 5645-51. PMID 18765473 DOI: 10.1093/Nar/Gkn558 |
0.761 |
|
| 2007 |
Chillemi G, Fiorani P, Bruselles A, Castelli S, Campagna A, Sarra O, Tesauro C, Fiorentini M, Vassallo O, D'Annessa I, Santoleri S, Desideri A. Role of flexibility and long range communication on the function of human topoisomerase I Italian Journal of Biochemistry. 56: 110-114. PMID 17722651 |
0.516 |
|
| 2007 |
Chillemi G, Bruselles A, Fiorani P, Bueno S, Desideri A. The open state of human topoisomerase I as probed by molecular dynamics simulation. Nucleic Acids Research. 35: 3032-8. PMID 17439970 DOI: 10.1093/Nar/Gkm199 |
0.519 |
|
| 2006 |
Fiorani P, Chillemi G, Losasso C, Castelli S, Desideri A. The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant. Nucleic Acids Research. 34: 5093-100. PMID 16990249 DOI: 10.1093/Nar/Gkl670 |
0.773 |
|
| 2006 |
Fiorani P, Bjornsti M. Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae. Annals of the New York Academy of Sciences. 922: 65-75. PMID 11193926 DOI: 10.1111/J.1749-6632.2000.Tb07026.X |
0.676 |
|
| 2005 |
Chillemi G, Fiorani P, Castelli S, Bruselles A, Benedetti P, Desideri A. Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study. Nucleic Acids Research. 33: 3339-50. PMID 15944452 DOI: 10.1093/Nar/Gki642 |
0.785 |
|
| 2004 |
Fiorani P, Reid RJ, Schepis A, Jacquiau HR, Guo H, Thimmaiah P, Benedetti P, Bjornsti MA. The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons. The Journal of Biological Chemistry. 279: 21271-81. PMID 14990574 DOI: 10.1074/Jbc.M312338200 |
0.782 |
|
| 2003 |
Fiorani P, Bruselles A, Falconi M, Chillemi G, Desideri A, Benedetti P. Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I. The Journal of Biological Chemistry. 278: 43268-75. PMID 12904303 DOI: 10.1074/Jbc.M303899200 |
0.806 |
|
| 2003 |
Chillemi G, Fiorani P, Benedetti P, Desideri A. Protein concerted motions in the DNA-human topoisomerase I complex. Nucleic Acids Research. 31: 1525-35. PMID 12595561 DOI: 10.1093/Nar/Gkg242 |
0.774 |
|
| 2001 |
Fiorani P, Hann CL, Benedetti P, Bjornsti M. Drug-induced stabilization of covalent DNA topoisomerase I-DNA intermediates. DNA cleavage assays. Methods of Molecular Biology. 95: 291-301. PMID 11089241 DOI: 10.1385/1-59259-057-8:291 |
0.758 |
|
| 1999 |
Reid RJ, Fiorani P, Sugawara M, Bjornsti MA. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 96: 11440-5. PMID 10500195 DOI: 10.1073/Pnas.96.20.11440 |
0.657 |
|
| 1999 |
FIORANI P., AMATRUDA JF, SILVESTRI, BJORNSTI MA, BUTLER RH, BENEDETTI P.. Domain Interactions Affecting Human DNA Topoisomerase I Catalysis and Camptothecin Sensitivity Molecular Pharmacology. pp. 1105-1115 I. DOI: 10.1124/Mol.56.6.1105 |
0.79 |
|
| 1997 |
Benedetti P, Silvestri A, Fiorani P, Wang JC. Study of yeast DNA topoisomerase II and its truncation derivatives by transmission electron microscopy Journal of Biological Chemistry. 272: 12132-12137. PMID 9115283 DOI: 10.1074/Jbc.272.18.12132 |
0.44 |
|
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