George L King - Publications

Affiliations: 
Joslin Diabetes Center Harvard Medical School, Boston, MA, United States 

259 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yu MG, Gordin D, Fu J, Park K, Li Q, King GL. Protective Factors and the Pathogenesis of Complications in Diabetes. Endocrine Reviews. PMID 37638875 DOI: 10.1210/endrev/bnad030  0.328
2022 Fickweiler W, Park H, Park K, Mitzner MG, Chokshi T, Boumenna T, Gautier J, Zaitsu Y, Wu IH, Cavallerano J, Aiello LP, Sun JK, King GL. Elevated Retinol Binding Protein 3 Concentrations Are Associated With Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy. Diabetes Care. PMID 35852358 DOI: 10.2337/dc22-0165  0.326
2022 Rathjen T, Kunkemoeller B, Cederquist CT, Wang X, Lockhart SM, Patti JC, Willenbrock H, Olsen GS, Povlsen GK, Beck HC, Rasmussen LM, Li Q, Park K, King GL, Rask-Madsen C. Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology. 101161101161ATVBAHA1. PMID 35652755 DOI: 10.1161/ATVBAHA.122.317476  0.332
2022 Fu J, Shinjo T, Li Q, St-Louis R, Park K, Yu MG, Yokomizo H, Simao F, Huang Q, Wu IH, King GL. Regenerating glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy. Jci Insight. PMID 35133981 DOI: 10.1172/jci.insight.155260  0.344
2021 Fu J, Yu MG, Li Q, Park K, King GL. Insulin Actions on the Vascular Tissues: Physiological Effects and Pathophysiological Contributions to Vascular Complications of Diabetes. Molecular Metabolism. 101236. PMID 33878400 DOI: 10.1016/j.molmet.2021.101236  0.345
2021 FICKWEILER W, PARK H, PARK K, BOUMENNA T, GAUTHIER J, WU I, CAVALLERANO JD, AIELLO LP, SUN J, KING GL. 87-OR: Vitreous Retinol Binding Protein 3 Is Increased in Patients without Advanced Diabetic Retinopathy in Type 1 and Type 2 Diabetes Diabetes. 70: 87-OR. DOI: 10.2337/db21-87-or  0.307
2021 PARK K, LI Q, PARK H, FU J, KISSLER S, MADDALONI E, WU I, LICHTMAN AH, KING GL. 54-OR: Nucleolin Autoantibody Accelerates Atherosclerosis in Type 1 Diabetes Diabetes. 70: 54-OR. DOI: 10.2337/db21-54-or  0.307
2020 Maddaloni E, Park K, Guida MD, Coraggio L, Luordi C, D’Onofrio L, Baroni MG, Cavallo MG, D’Angelo P, Cosmo SD, Leonetti F, Morano S, Morviducci L, Pozzilli P, Prudente S, ... ... King GL, et al. 570-P: Osteoprotegerin Induces Endothelial Dysfunction and Is Associated with Vascular Complications In Type 2 Diabetes Diabetes. 69. DOI: 10.2337/Db20-570-P  0.384
2020 St-Louis R, Fu J, Park K, Shinjo T, Ludeke J, Yokomizo H, Li Q, Wolfson E, King GL. 480-P: Reversal of Diabetic Nephropathy in T2D db/db Mouse Model by Systemic Pyruvate Kinase M2 (PKM2) Activation Diabetes. 69. DOI: 10.2337/Db20-480-P  0.387
2020 Li Q, Fu J, Park K, Zaitsu Y, St-Louis R, Rask-Madsen C, King GL. 456-P: Targeted Deletion of Insulin Receptor in Vascular Smooth Muscle Cells Accelerated Thinning of Plaque Cap and Apoptosis and Atherosclerosis Diabetes. 69. DOI: 10.2337/Db20-456-P  0.334
2020 Park K, Li Q, Park H, St-Louis R, Fu J, Rask-Madsen C, Maddaloni E, Yokomizo H, Kissler S, Lichtman AH, King GL. 436-P: Characterization of Autoimmunity in the Acceleration of Atherosclerosis in Type 1 Diabetes Diabetes. 69. DOI: 10.2337/Db20-436-P  0.399
2020 Yu MG, Shah H, Wolfson E, Bahnam V, Gauthier J, Cai Q, Jha V, Tsao C, King GL. 407-P: Cardiac and Retinal Imaging Studies Suggest Comparable Protective Factors between Cardiovascular Disease and Retinopathy in Long Duration Type 1 Diabetes Diabetes. 69. DOI: 10.2337/Db20-407-P  0.378
2020 Fickweiler W, Park K, Wolfson E, Park H, Yokomizo H, Wu I, Gordin D, Harjutsalo V, Groop P, Aiello LP, Sun J, King GL. 327-OR: Association of Retinol Binding Protein 3 with Retinal Neural Structure and Clinical Parameters in Diabetic Retinopathy Diabetes. 69. DOI: 10.2337/Db20-327-Or  0.359
2020 Ishikado A, Shinjo T, Yokomizo H, Maeda Y, Park K, Qi W, St-Louis R, Li Q, King GL. 309-OR: IGF-1 Receptors, Not Insulin Receptors, on Mesangial Cells Are Accelerating Mesangial Expansion and Albuminuria in Streptozotocin-Induced Diabetic Mice Diabetes. 69. DOI: 10.2337/Db20-309-Or  0.416
2020 Fu J, Shinjo T, St-Louis R, Li Q, Park K, Yokomizo H, Zaitsu Y, Yu MG, Wu I, Shah H, King GL. 307-OR: Activation of Mitochondrial Activities by Pyruvate Kinase M2 (PKM2) in Podocytes Improved Glomerular Metabolism and Diabetic Nephropathy Diabetes. 69. DOI: 10.2337/Db20-307-Or  0.366
2020 Wolfson E, Fickweiler W, Sampani K, Shah H, Aiello LP, Sun J, King GL. 284-OR: Characterization of Cognitive Changes in Type 1 Diabetes of Extreme Duration by Retinal Neural Structure and Vasculature Diabetes. 69. DOI: 10.2337/Db20-284-Or  0.369
2020 Yokomizo H, Ishikado A, Shinjo T, Park K, Maeda Y, Li Q, Wu I, Matsumoto M, Devkota S, Kostic A, King GL. 1867-P: White and Brown Rice Supplementation Changes High-Fat Diet–Induced Dysbiosis of Gut Microbiome and Improves Energy and Glucose Metabolism Diabetes. 69. DOI: 10.2337/Db20-1867-P  0.313
2020 Shah H, Wolfson E, Yu MG, Adam A, Hu F, King GL. 1543-P: Dietary Inflammatory Index Associated with Complications in Long Duration Type 1 Diabetes Diabetes. 69. DOI: 10.2337/Db20-1543-P  0.375
2019 Fickweiler W, Aiello LP, Sun JK, King GL. Retinol binding protein 3 as biomarker for diabetic retinopathy. Annals of Translational Medicine. 7: 706. PMID 31930216 DOI: 10.21037/Atm.2019.10.95  0.415
2019 Vaisar T, Kanter JE, Wimberger J, Irwin AD, Gauthier J, Wolfson E, Bahnam V, Wu IH, Shah H, Keenan HA, Greenbaum CJ, King GL, Heinecke JW, Bornfeldt KE. High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes. Diabetes Care. PMID 31597668 DOI: 10.2337/Dc19-0772  0.4
2019 Li Q, Fu J, Xia Y, Qi W, Ishikado A, Park K, Yokomizo H, Huang Q, Cai W, Rask-Madsen C, Kahn CR, King GL. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nature Communications. 10: 4427. PMID 31562314 DOI: 10.1038/S41467-019-12368-2  0.41
2019 Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, ... ... King GL, et al. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Science Translational Medicine. 11. PMID 31270273 DOI: 10.1126/Scitranslmed.Aau6627  0.466
2019 Yu MG, Keenan HA, Shah HS, Frodsham SG, Pober D, He Z, Wolfson EA, D'Eon S, Tinsley LJ, Bonner-Weir S, Pezzolesi MG, King GL. Residual β cell function and monogenic variants in long-duration type 1 diabetes patients. The Journal of Clinical Investigation. 130. PMID 31264968 DOI: 10.1172/Jci127397  0.425
2019 Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, ... ... King GL, et al. Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Diabetes Care. PMID 31076418 DOI: 10.2337/Dc18-2585  0.439
2019 Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL. Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration. Journal of Periodontology. PMID 31026349 DOI: 10.1002/Jper.18-0735  0.422
2019 PANIAGUA SM, FICKWEILER W, BAHNAM V, SAMPANI K, WU I, SHAH H, MUSEN G, AIELLO LP, SUN JK, KING GL. 86-OR: Association of Cognitive Function with Retinal Neural Structure and Vasculature in Type 1 Diabetes Diabetes. 68: 86-OR. DOI: 10.2337/Db19-86-Or  0.34
2019 SHINJO T, LI Q, ISHIKADO A, PARK K, ST-LOUIS R, YOKOMIZO H, FU J, YU MG, WANG H, HASTURK H, VAN DYKE TE, KING GL. 628-P: Insulin's Regulation of CXCL1 Expression Is Critical for Neutrophil Recruitments and the Development of Periodontitis and Poor Wound Healing in Diabetes Diabetes. 68: 628-P. DOI: 10.2337/db19-628-p  0.3
2019 YU MG, PEZZOLESI MG, KEENAN HA, POBER DM, HE Z, TINSLEY LJ, DORIA A, BONNER-WEIR S, KING GL. 61-OR: ADA Presidents' Select Abstract: Characterization of Beta-Cell Function with Autoantibodies, Islet Pathology, and Genetics after 50 Years of Insulin Dependence Diabetes. 68: 61-OR. DOI: 10.2337/Db19-61-Or  0.386
2019 YOKOMIZO H, PARK K, CLERMONT A, MAEDA Y, FICKWEILER W, ISHIKADO A, LI Q, WANG C, POBER DM, WU I, KEENAN HA, AIELLO LP, SUN JK, KING GL. 597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity Diabetes. 68: 597-P. DOI: 10.2337/Db19-597-P  0.425
2019 Fickweiler W, Yokomizo H, Park K, Paniagua SM, Wu I, Pober DM, Bahnam V, Clermont A, Aiello LP, Sun JK, King GL. 586-P: Vitreous and Serum Measurements of Retinol Binding Protein 3 in the Clinical Evaluation of Diabetic Retinopathy Diabetes. 68. DOI: 10.2337/Db19-586-P  0.357
2019 Park K, Li Q, Wang H, St-Louis R, Yokomizo H, Maddaloni E, Shinjo T, Fu J, Wu I, Kissler S, King GL. 478-P: Accelerating Atherosclerosis by Autoimmune Process in Nonobese Diabetic Mice Made ApoE Deficient by CRISPR/Cas9 Gene Editing Diabetes. 68. DOI: 10.2337/Db19-478-P  0.369
2019 Kunkemoeller B, Rathjen T, Patti JC, Li Q, Park K, King GL, Rask-Madsen C. 273-LB: Leukocyte-Endothelial Interaction Is Reduced by Insulin-Induced Downregulation of Endothelial CXCR4 Diabetes. 68. DOI: 10.2337/Db19-273-Lb  0.416
2019 Shinjo T, St-Louis R, Fu J, Park K, Li Q, Yokomizo H, Yu MG, Wang H, Kannt A, Sadowski T, King GL. 231-OR: ADA Presidents' Select Abstract: Pyruvate Kinase M2 Overexpression in Podocytes Ameliorates Nephropathy in Diabetic Mice Diabetes. 68. DOI: 10.2337/Db19-231-Or  0.4
2018 Pongrac Barlovic D, Harjutsalo V, Gordin D, Kallio M, Forsblom C, King G, Groop PH. The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up. Diabetes Care. PMID 30257963 DOI: 10.2337/Dc18-0476  0.422
2018 Gordin D, King GL. Response to Comment on Gordin et al. Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 2018;41:815-822. Diabetes Care. 41: e128. PMID 29934489 DOI: 10.2337/Dci18-0021  0.42
2018 Musen G, Tinsley LJ, Marcinkowski KA, Pober D, Sun JK, Khatri M, Huynh R, Lu A, King GL, Keenan HA. Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications. Diabetes Care. PMID 29871904 DOI: 10.2337/Dc17-1955  0.341
2018 Qi W, Li Q, Gordin D, King GL. Preservation of renal function in chronic diabetes by enhancing glomerular glucose metabolism. Journal of Molecular Medicine (Berlin, Germany). PMID 29574544 DOI: 10.1007/S00109-018-1630-0  0.402
2018 Roshandel D, Gubitosi-Klug R, Bull SB, Canty AJ, Pezzolesi MG, King GL, Keenan HA, Snell-Bergeon JK, Maahs DM, Klein R, Klein BEK, Orchard TJ, Costacou T, Weedon MN, et al. Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia. PMID 29404672 DOI: 10.1007/S00125-018-4555-9  0.325
2018 Gordin D, Harjutsalo V, Tinsley L, Fickweiler W, Sun JK, Forsblom C, Amenta PS, Pober D, D'Eon S, Khatri M, Stillman IE, Groop PH, Keenan HA, King GL. Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care. PMID 29386250 DOI: 10.2337/Dc17-2250  0.404
2018 GORDIN D, SHINJO T, ST-LOUIS R, QI W, TINSLEY LJ, POBER DM, BRISSETT MJ, NIEWCZAS M, DREYFUSS J, PAN H, SADOWSKI T, KANNT A, SHAH H, KEENAN HA, KROLEWSKI A, ... KING GL, et al. Activation of PKM2 Protects against Diabetic Kidney Disease from Mice to Men Diabetes. 67: 91-OR. DOI: 10.2337/Db18-91-Or  0.411
2018 LI Q, FU J, PARK K, CHRISTIAN R, KING GL. Loss of Insulin Actions on Arterial Smooth Muscle Cells May Enhance Unstable Atherosclerotic Plaque Formation Diabetes. 67: 288-OR. DOI: 10.2337/Db18-288-Or  0.382
2018 Park K, Li Q, Lynes M, Yokomizo H, Shinjo T, St-Louis R, Fu J, Rask-Madsen C, Tseng Y, King GL. Endothelial/Nitric Oxide Regulation of Brown Adipose Tissue Activating Lipokine, 12, 13-diHOME and Its Antiatherogenic Actions Diabetes. 67. DOI: 10.2337/Db18-286-Or  0.342
2018 YOKOMIZO H, PARK K, CLERMONT A, MAEDA Y, FICKWEILER W, ISHIKADO A, LI Q, TINSLEY LJ, POBER DM, WU I, AIELLO LP, KEENAN HA, SUN J, KING GL. Diabetic Retinopathy Reversed by Intravitreous Application of Retinol Binding Protein 3 Diabetes. 67: 245-OR. DOI: 10.2337/Db18-245-Or  0.44
2018 Rathjen T, Li Q, Park K, Povlsen G, Olsen GS, King GL, Rask-Madsen C. Insulin Action on Endothelial Cells Limits Leukocyte-Endothelial Interaction through CXCR4 and Counteracts Intestinal Tumor Formation in Obesity Diabetes. 67. DOI: 10.2337/Db18-2033-P  0.388
2018 SHINJO T, ISHIKADO A, HASTURK H, TINSLEY LJ, POBER DM, WU I, VAN DYKE TE, GENCO RJ, KING GL. Protection from Severe Periodontal Disease among People with Type 1 Diabetes with Duration of 50 Years or Longer Diabetes. 67: 1585-P. DOI: 10.2337/Db18-1585-P  0.315
2018 Katz M, King GL, Sun J, Laffel LM. Diabetes Retinopathy (DR) Relates to Complication Risk in Young Persons with T1D Diabetes. 67. DOI: 10.2337/Db18-1367-P  0.389
2018 KAREN LAU KH, POBER DM, MEHTA SN, HSU WC, KING GL. Culturally-Specific Diabetes Care Reduces Disparities in Metabolic Control Diabetes. 67: 1328-P. DOI: 10.2337/Db18-1328-P  0.354
2017 Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29162603 DOI: 10.1161/Atvbaha.117.310291  0.449
2017 Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, Vinik AI, Casellini CM. Diabetic Microvascular Disease: An Endocrine Society Scientific Statement. The Journal of Clinical Endocrinology and Metabolism. PMID 29126250 DOI: 10.1210/Jc.2017-01922  0.418
2017 Tinsley LJ, Kupelian V, D'Eon SA, Pober D, Sun JK, King GL, Keenan HA. Association of glycemic control with reduced risk of large vessel disease after more than 50 years of type 1 diabetes. The Journal of Clinical Endocrinology and Metabolism. PMID 28973526 DOI: 10.1210/Jc.2017-00589  0.417
2017 Maddaloni E, Xia Y, Park K, D'Eon S, Tinsley LJ, St-Louis R, Khamaisi M, Li Q, King GL, Keenan HA. High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes. Cardiovascular Diabetology. 16: 116. PMID 28915881 DOI: 10.1186/S12933-017-0599-2  0.399
2017 Li Q, Park K, Xia Y, Matsumoto M, Qi W, Fu J, Yokomizo H, Khamaisi M, Wang X, Rask-Madsen C, King GL. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid Induced PKCδ Isoform Activation. Circulation Research. PMID 28855204 DOI: 10.1161/Circresaha.117.311606  0.366
2017 Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, ... ... King GL, et al. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nature Medicine. PMID 28436957 DOI: 10.1038/Nm.4328  0.409
2017 Noh H, Yu MR, Kim HJ, Lee JH, Park BW, Wu IH, Matsumoto M, King GL. Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications. Kidney International. PMID 28396116 DOI: 10.1016/J.Kint.2017.02.013  0.4
2017 Rask-Madsen C, Park K, Li Q, King GL. Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circulation Research. 120: e2-e3. PMID 28209799 DOI: 10.1161/Circresaha.116.310491  0.416
2016 Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, King GL. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. PMID 27933336 DOI: 10.1007/S00125-016-4159-1  0.468
2016 King GL, Park K, Li Q. Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture. Diabetes. 65: 1462-71. PMID 27222390 DOI: 10.2337/Db16-0152  0.511
2016 Katagiri S, Park K, Maeda Y, Rao TN, Khamaisi M, Li Q, Yokomizo H, Mima A, Lancerotto L, Wagers A, Orgill DP, King GL. Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance. Diabetes. PMID 27217486 DOI: 10.2337/Db15-1721  0.467
2016 Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, ... King GL, et al. Insulin decreases atherosclerosis by inducing endothelin receptor B expression. Jci Insight. 1. PMID 27200419 DOI: 10.1172/Jci.Insight.86574  0.455
2016 Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL. PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. The Journal of Clinical Investigation. PMID 26808499 DOI: 10.1172/Jci82788  0.458
2016 Noh H, Yu MR, Kim HJ, Lee SN, King G. SP376β2 ADRENERGIC RECEPTOR AGONISTS: NOVEL REGULATORS OF MACROPHAGE ACTIVATION IN DIABETIC RENAL AND CARDIOVASCULAR COMPLICATIONS Nephrology Dialysis Transplantation. 31. DOI: 10.1093/Ndt/Gfw168.03  0.381
2015 Agarwal I, Glazer NL, Barasch E, Djousse L, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, Siscovick DS, King GL, Mukamal KJ. Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study. Metabolism: Clinical and Experimental. 64: 1316-23. PMID 26282733 DOI: 10.1016/J.Metabol.2015.07.013  0.3
2015 Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, ... ... King GL, et al. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metabolism. 22: 239-52. PMID 26244933 DOI: 10.1016/J.Cmet.2015.07.015  0.325
2015 He ZH, D'Eon SA, Tinsley LJ, Fitzgerald S, Hastings SM, Khamaisi M, Sun JK, Turek SJ, Schaefer EJ, King GL, Keenan HA. Cardiovascular disease protection in long-duration type 1 diabetes and sex differences. Diabetes Care. 38: e73-4. PMID 25908159 DOI: 10.2337/Dc15-0017  0.366
2015 Durpès MC, Morin C, Paquin-Veillet J, Beland R, Paré M, Guimond MO, Rekhter M, King GL, Geraldes P. PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis. Cardiovascular Research. 106: 303-13. PMID 25808972 DOI: 10.1093/Cvr/Cvv107  0.359
2014 Hsu WC, Lau KH, Matsumoto M, Moghazy D, Keenan H, King GL. Improvement of insulin sensitivity by isoenergy high carbohydrate traditional Asian diet: a randomized controlled pilot feasibility study. Plos One. 9: e106851. PMID 25226279 DOI: 10.1371/Journal.Pone.0106851  0.327
2014 Hernandez SL, Gong JH, Chen L, Wu IH, Sun JK, Keenan HA, King GL. Characterization of circulating and endothelial progenitor cells in patients with extreme-duration type 1 diabetes. Diabetes Care. 37: 2193-201. PMID 24780357 DOI: 10.2337/Dc13-2547  0.426
2014 Mizutani K, Park K, Mima A, Katagiri S, King GL. Obesity-associated Gingival Vascular Inflammation and Insulin Resistance. Journal of Dental Research. 93: 596-601. PMID 24744283 DOI: 10.1177/0022034514532102  0.386
2013 Turek SJ, Hastings SM, Sun JK, King GL, Keenan HA. Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care. 36: 3222-6. PMID 23780949 DOI: 10.2337/Dc13-0294  0.391
2013 Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Molecular and Cellular Biology. 33: 3227-41. PMID 23775122 DOI: 10.1128/Mcb.00506-13  0.38
2013 Le H, Wong S, Iftikar T, Keenan H, King GL, Hsu WC. Characterization of factors affecting attainment of glycemic control in Asian Americans with diabetes in a culturally specific program. The Diabetes Educator. 39: 468-77. PMID 23771841 DOI: 10.1177/0145721713492217  0.36
2013 Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circulation Research. 113: 418-27. PMID 23759514 DOI: 10.1161/Circresaha.113.301074  0.431
2013 Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metabolism. 17: 20-33. PMID 23312281 DOI: 10.1016/J.Cmet.2012.11.012  0.454
2013 Ishikado A, Sono Y, Matsumoto M, Robida-Stubbs S, Okuno A, Goto M, King GL, Blackwell TK, Makino T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radical Biology & Medicine. 65: 1506-15. PMID 23277146 DOI: 10.1016/J.Freeradbiomed.2012.12.006  0.311
2012 Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Investigative Ophthalmology & Visual Science. 53: 8424-32. PMID 23197686 DOI: 10.1167/Iovs.12-10207  0.453
2012 Mima A, Qi W, King GL. Implications of treatment that target protective mechanisms against diabetic nephropathy. Seminars in Nephrology. 32: 471-8. PMID 23062988 DOI: 10.1016/J.Semnephrol.2012.07.010  0.477
2012 Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes. Diabetes. 61: 2967-79. PMID 22826029 DOI: 10.2337/Db11-1824  0.428
2012 Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R. Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care. 35: 1189-98. PMID 22517940 DOI: 10.2337/Dc12-0212  0.428
2012 King GL, McNeely MJ, Thorpe LE, Mau ML, Ko J, Liu LL, Sun A, Hsu WC, Chow EA. Understanding and addressing unique needs of diabetes in Asian Americans, native Hawaiians, and Pacific Islanders. Diabetes Care. 35: 1181-8. PMID 22517939 DOI: 10.2337/Dc12-0210  0.336
2012 Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL. Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2963-74. PMID 22499584 DOI: 10.1096/Fj.11-202994  0.49
2012 Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL. Hyperinsulinemia does not change atherosclerosis development in Apolipoprotein e null mice Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1124-1131. PMID 22426129 DOI: 10.1161/Atvbaha.111.239558  0.34
2012 Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K) Journal of Biological Chemistry. 287: 4518-4530. PMID 22158866 DOI: 10.1074/Jbc.M111.286591  0.426
2011 Hsu WC, Okeke E, Cheung S, Keenan H, Tsui T, Cheng K, King GL. A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. Plos One. 6: e28311. PMID 22164267 DOI: 10.1371/Journal.Pone.0028311  0.444
2011 Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. The Journal of Clinical Investigation. 121: 2504-17. PMID 21576825 DOI: 10.1172/Jci46045  0.349
2011 Jeong IK, King GL. New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes & Metabolism Journal. 35: 8-11. PMID 21537407 DOI: 10.4093/Dmj.2011.35.1.8  0.461
2011 Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care. 34: 968-74. PMID 21447665 DOI: 10.2337/Dc10-1675  0.409
2011 Rask-Madsen C, King GL. Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metabolism. 13: 236-8. PMID 21356512 DOI: 10.1016/J.Cmet.2011.02.008  0.338
2011 Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL. Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney International. 79: 883-96. PMID 21228767 DOI: 10.1038/Ki.2010.526  0.48
2011 Stanton RC, King GL. A complex interplay of factors causes diabetic nephropathy. Metabolism: Clinical and Experimental. 60: 591-3. PMID 21109270 DOI: 10.1016/J.Metabol.2010.10.004  0.398
2011 Jeong IK, King GL. New perspectives on diabetic vascular complications: The loss of endogenous protective factors induced by hyperglycemia Diabetes and Metabolism Journal. 35: 8-11. DOI: 10.4093/dmj.2011.35.1.8  0.373
2011 Sun JK, Keenan HA, Monnier VM, Aiello LP, King GL. Response to comment on: Sun et al. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: The Joslin 50-year Medalist Study. Diabetes Care 2011;34:968-974 Diabetes Care. 34. DOI: 10.2337/Dc11-1188  0.379
2010 King GL, Das-Evcimen N. Role of protein kinase C in diabetic complications. Expert Review of Endocrinology & Metabolism. 5: 77-88. PMID 30934385 DOI: 10.1586/Eem.09.74  0.485
2010 Kitada M, Zhang Z, Mima A, King GL. Molecular mechanisms of diabetic vascular complications. Journal of Diabetes Investigation. 1: 77-89. PMID 24843412 DOI: 10.1111/J.2040-1124.2010.00018.X  0.489
2010 Rask-Madsen C, King GL. Diabetes: Podocytes lose their footing. Nature. 468: 42-4. PMID 21048754 DOI: 10.1038/468042A  0.464
2010 Cao L, Arany PR, Kim J, Rivera-Feliciano J, Wang YS, He Z, Rask-Madsen C, King GL, Mooney DJ. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 31: 9048-56. PMID 20800279 DOI: 10.1016/J.Biomaterials.2010.08.002  0.442
2010 Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 59: 2846-53. PMID 20699420 DOI: 10.2337/Db10-0676  0.433
2010 Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, ... ... King GL, et al. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metabolism. 11: 379-89. PMID 20444418 DOI: 10.1016/J.Cmet.2010.03.013  0.426
2010 Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circulation Research. 106: 1319-31. PMID 20431074 DOI: 10.1161/Circresaha.110.217117  0.485
2010 Rask-Madsen C, King GL. Kidney complications: factors that protect the diabetic vasculature. Nature Medicine. 16: 40-1. PMID 20057426 DOI: 10.1038/Nm0110-40  0.41
2010 Keenan HA, Bonner-Weir S, King GL. Response to comment on: Keenan et al. (2010) residual insulin production and pancreatic β-cell turnover after 50 years of diabetes: Joslin medalist study. Diabetes 2010;59:2846-2853 Diabetes. 59. DOI: 10.2337/Db10-1277  0.354
2009 Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nature Medicine. 15: 1298-306. PMID 19881493 DOI: 10.1038/Nm.2052  0.493
2009 Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Molecular Endocrinology (Baltimore, Md.). 23: 1281-90. PMID 19407223 DOI: 10.1210/Me.2008-0482  0.341
2008 Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney International. 74: 1434-43. PMID 19008912 DOI: 10.1038/Ki.2008.403  0.423
2008 Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. The Journal of Biological Chemistry. 283: 34327-36. PMID 18854316 DOI: 10.1074/Jbc.M807036200  0.427
2008 King GL. The role of inflammatory cytokines in diabetes and its complications. Journal of Periodontology. 79: 1527-34. PMID 18673007 DOI: 10.1902/Jop.2008.080246  0.474
2008 Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, ... ... King GL, et al. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proceedings of the National Academy of Sciences of the United States of America. 105: 6998-7003. PMID 18458324 DOI: 10.1073/Pnas.0800454105  0.406
2008 Rask-Madsen C, King GL. More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 608-10. PMID 18354093 DOI: 10.1161/Atvbaha.108.162057  0.497
2008 Rask-Madsen C, King GL. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 919-24. PMID 18323518 DOI: 10.1161/Atvbaha.108.162842  0.348
2008 Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metabolism. 7: 125-34. PMID 18249172 DOI: 10.1016/J.Cmet.2007.11.013  0.322
2007 Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 48: 5750-5. PMID 18055828 DOI: 10.1167/Iovs.07-0470  0.32
2007 Noh H, King GL. The role of protein kinase C activation in diabetic nephropathy Kidney International. Supplement. PMID 17653211 DOI: 10.1038/Sj.Ki.5002386  0.486
2007 Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacological Research. 55: 498-510. PMID 17574431 DOI: 10.1016/J.Phrs.2007.04.016  0.519
2007 Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 30: 1995-7. PMID 17507696 DOI: 10.2337/Dc06-2222  0.429
2007 Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 56: 1410-20. PMID 17363743 DOI: 10.2337/Db06-0655  0.446
2007 Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 56: 1551-8. PMID 17360984 DOI: 10.2337/Db06-1033  0.421
2007 Engelgau MM, Vinicor F, Simionescu M, King GL, Meininger C, Mensah GA. Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascular Pharmacology. 46: 324-6. PMID 17275418 DOI: 10.1016/J.Vph.2006.10.015  0.364
2007 Rask-Madsen C, King GL. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nature Clinical Practice. Endocrinology & Metabolism. 3: 46-56. PMID 17179929 DOI: 10.1038/Ncpendmet0366  0.487
2006 Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 55: 3112-20. PMID 17065350 DOI: 10.2337/Db06-0895  0.418
2006 Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2058-67. PMID 17012258 DOI: 10.1096/05-5662Com  0.357
2006 Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1203-5. PMID 16672634 DOI: 10.1096/Fj.05-4617Fje  0.4
2006 Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 55: 691-8. PMID 16505232 DOI: 10.2337/Diabetes.55.03.06.Db05-0771  0.423
2006 He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 787-93. PMID 16469952 DOI: 10.1161/01.Atv.0000209500.15801.4E  0.38
2006 Hsu WC, Cheung S, Ong E, Wong K, Lin S, Leon K, Weinger K, King GL. Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes. Diabetes Care. 29: 415-6. PMID 16443897 DOI: 10.2337/Diacare.29.02.06.Dc05-1915  0.4
2005 He Z, King GL. Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care. 28: 2803-5. PMID 16249561 DOI: 10.2337/Diacare.28.11.2803  0.481
2005 Ahmad FK, He Z, King GL. Molecular targets of diabetic cardiovascular complications. Current Drug Targets. 6: 487-94. PMID 16026267 DOI: 10.2174/1389450054021990  0.455
2005 Xu Y, He Z, King GL. Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Current Diabetes Reports. 5: 91-7. PMID 15794910 DOI: 10.1007/S11892-005-0034-Z  0.498
2005 He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. The Journal of Biological Chemistry. 280: 15719-26. PMID 15699040 DOI: 10.1074/Jbc.M413493200  0.423
2005 Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1240-8. PMID 15689562 DOI: 10.1523/Jneurosci.3664-04.2005  0.376
2005 Rask-Madsen C, King GL. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 487-96. PMID 15637306 DOI: 10.1161/01.Atv.0000155325.41507.E0  0.501
2005 Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell SE, King GL, Johnstone MT, Horton ES, Veves A. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes. 54: 204-11. PMID 15616030 DOI: 10.2337/Diabetes.54.1.204  0.308
2004 Scott JA, King GL. Oxidative stress and antioxidant treatment in diabetes. Annals of the New York Academy of Sciences. 1031: 204-13. PMID 15753146 DOI: 10.1196/Annals.1331.020  0.421
2004 Treszl A, Szereday L, Doria A, King GL, Orban T. Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes Diabetes Care. 27: 2769-2770. PMID 15505025 DOI: 10.2337/Diacare.27.11.2769  0.396
2004 King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochemistry and Cell Biology. 122: 333-8. PMID 15257460 DOI: 10.1007/S00418-004-0678-9  0.41
2004 He Z, King GL. Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation. 110: 7-9. PMID 15238466 DOI: 10.1161/01.Cir.0000133428.02295.6C  0.492
2004 Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. The Journal of Biological Chemistry. 279: 30369-74. PMID 15128745 DOI: 10.1074/Jbc.M400549200  0.396
2004 He Z, King GL. Microvascular complications of diabetes. Endocrinology and Metabolism Clinics of North America. 33: 215-38, xi-xii. PMID 15053904 DOI: 10.1016/J.Ecl.2003.12.003  0.442
2004 Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Retinopathy in diabetes. Diabetes Care. 27: S84-7. PMID 14693935 DOI: 10.2337/Diacare.27.2007.S84  0.447
2004 Yasuda Y, King GL. The role of protein kinase C activation in cardiovascular dysfunctions of diabetes and insulin resistance International Congress Series. 1262: 152-155. DOI: 10.1016/J.ICS.2003.12.012  0.357
2003 Kuroki T, Isshiki K, King GL. Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. Journal of the American Society of Nephrology. 14. PMID 12874434 DOI: 10.1097/01.Asn.0000077405.07888.07  0.377
2003 Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. The Journal of Clinical Investigation. 111: 1835-42. PMID 12813019 DOI: 10.1172/JCI17455  0.311
2003 Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. The Journal of Biological Chemistry. 278: 31964-71. PMID 12775712 DOI: 10.1074/Jbc.M303314200  0.411
2003 Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR. The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. The Journal of Clinical Investigation. 111: 1373-80. PMID 12727929 DOI: 10.1172/Jci15211  0.397
2003 Yokota T, Ma RC, Park JY, Isshiki K, Sotiropoulos KB, Rauniyar RK, Bornfeldt KE, King GL. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes. 52: 838-845. PMID 12606528 DOI: 10.2337/Diabetes.52.3.838  0.457
2003 Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 52: 829-37. PMID 12606527 DOI: 10.2337/Diabetes.52.3.829  0.445
2003 Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 26: 226-9. PMID 12502685 DOI: 10.2337/diacare.26.1.226  0.316
2003 Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 26: S99-S102. PMID 12502630  0.316
2003 Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. The Journal of Biological Chemistry. 278: 6976-84. PMID 12493764 DOI: 10.1074/Jbc.M208974200  0.341
2003 Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR. Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization Journal of Clinical Investigation. 111: 1835-1842. DOI: 10.1172/Jci200317455  0.421
2003 Lee HB, Ha H, King GL. Reactive Oxygen Species and Diabetic Nephropathy Journal of the American Society of Nephrology. 14. DOI: 10.1097/01.Asn.0000077403.06195.D2  0.423
2003 King G. 1FS01-3 The role of protein kinase C activation in cardiovascular dysfunction in diabetes and insulin resistance Atherosclerosis Supplements. 4: 5. DOI: 10.1016/S1567-5688(03)90023-7  0.356
2003 Abiko T, Abiko A, Clermont AC, Shlelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes. Role of oxidants and protein kinase-c activation11Edited by Hans E. Grossniklaus, MD American Journal of Ophthalmology. 136: 786-787. DOI: 10.1016/S0002-9394(03)00801-8  0.433
2002 Sheetz MJ, King GL. Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications Jama. 288: 2579-2588. PMID 12444865 DOI: 10.1001/Jama.288.20.2579  0.453
2002 Hiramatsu Y, Sekiguchi N, Hayashi M, Isshiki K, Yokota T, King GL, Loeken MR. Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes. 51: 2804-10. PMID 12196474 DOI: 10.2337/Diabetes.51.9.2804  0.449
2002 Way KJ, Isshiki K, Suzuma K, Yokota T, Zvagelsky D, Schoen FJ, Sandusky GE, Pechous PA, Vlahos CJ, Wakasaki H, King GL. Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes. 51: 2709-18. PMID 12196463 DOI: 10.2337/Diabetes.51.9.2709  0.383
2002 Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes Circulation. 105: e138-143. PMID 11994264 DOI: 10.1161/01.Cir.0000013954.65303.C5  0.426
2002 Suzuma K, Takahara N, Suzuma I, Isshiki K, Ueki K, Leitges M, Aiello LP, King GL. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proceedings of the National Academy of Sciences of the United States of America. 99: 721-6. PMID 11805327 DOI: 10.1073/Pnas.022644499  0.382
2002 Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 105: 373-9. PMID 11804995 DOI: 10.1161/Hc0302.102143  0.478
2002 Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC. Involvement of Protein Kinase C β2 in c-mycInduction by High Glucose in Pancreatic β-Cells Journal of Biological Chemistry. 277: 3680-3685. PMID 11714718 DOI: 10.1074/Jbc.M109647200  0.356
2002 Suzuma I, Suzuma K, Ueki K, Hata Y, Feener EP, King GL, Aiello LP. Stretch-induced Retinal Vascular Endothelial Growth Factor Expression Is Mediated by Phosphatidylinositol 3-Kinase and Protein Kinase C (PKC)-ζ but Not by Stretch-induced ERK1/2, Akt, Ras, or Classical/Novel PKC Pathways Journal of Biological Chemistry. 277: 1047-1057. PMID 11694503 DOI: 10.1074/Jbc.M105336200  0.358
2001 Way KJ, Katai N, King GL. Protein kinase C and the development of diabetic vascular complications. Diabetic Medicine : a Journal of the British Diabetic Association. 18: 945-59. PMID 11903393 DOI: 10.1046/J.0742-3071.2001.00638.X  0.498
2001 Rösen P, Nawroth PP, King G, Möller W, Tritschler HJ, Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes/Metabolism Research and Reviews. 17: 189-212. PMID 11424232 DOI: 10.1002/dmrr.196  0.338
2001 Veves A, King GL. Can VEGF reverse diabetic neuropathy in human subjects Journal of Clinical Investigation. 107: 1215-1218. PMID 11375408 DOI: 10.1172/Jci13038  0.397
2001 Faries PL, Rohan DI, Takahara H, Wyers MC, Contreras MA, Quist WC, King GL, Logerfo FW. Human vascular smooth muscle cells of diabetic origin exhibit increased proliferation, adhesion, and migration. Journal of Vascular Surgery. 33: 601-7. PMID 11241133 DOI: 10.1067/Mva.2001.111806  0.435
2001 Gabriele A, King GL. Protein kinase C inhibitors in the treatment and prevention of diabetic complications Current Opinion in Endocrinology and Diabetes. 8: 197-204. DOI: 10.1097/00060793-200108000-00006  0.459
2001 Park J, Takahara N, Gabriele A, Chou E, Naruse K, Suzuma K, Yamauchi T, Ha S, Meier M, Rhodes C, King G. Induction Of Endothelin‐1 Expression By Glucose: An Effect Of Protein Kinase C Activation Journal of the Peripheral Nervous System. 6: 60-61. DOI: 10.1046/J.1529-8027.2001.01008-3.X  0.326
2000 Meier M, King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vascular Medicine. 5: 173-185. PMID 11104300 DOI: 10.1177/1358836X0000500307  0.464
2000 Feng D, Bursell SE, Clermont AC, Lipinska I, Aiello LP, Laffel L, King GL, Tofler GH. von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes. Diabetes Care. 23: 1694-8. PMID 11092294 DOI: 10.2337/Diacare.23.11.1694  0.393
2000 Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. The Journal of Biological Chemistry. 275: 40725-31. PMID 11018037 DOI: 10.1074/Jbc.M006509200  0.374
2000 Park JY, Takahara N, Gabriele A, Chou E, Naruse K, Suzuma K, Yamauchi T, Ha SW, Meier M, Rhodes CJ, King GL. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 49: 1239-48. PMID 10909984 DOI: 10.2337/Diabetes.49.7.1239  0.416
2000 Naruse K, King GL. Protein Kinase C and Myocardial Biology and Function Circulation Research. 86: 1104-1106. PMID 10850959 DOI: 10.1161/01.Res.86.11.1104  0.329
2000 Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes The Faseb Journal. 14: 439-447. PMID 10698958 DOI: 10.1096/Fasebj.14.3.439  0.431
2000 Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 101: 676-81. PMID 10673261 DOI: 10.1161/01.Cir.101.6.676  0.416
2000 Luley C, Ronquist G, Reuter W, Paal V, Gottschling H, Westphal S, King GL, Bakker SJL, Heine RJ, Hattemer A. Point-of-care testing of triglycerides: evaluation of the Accutrend triglycerides system. Clinical Chemistry. 46: 287-291. DOI: 10.1093/Clinchem/46.2.287  0.345
2000 Bursell S, King GL. The Potential Use of Glutathionyl Hemoglobin as a Clinical Marker of Oxidative Stress Clinical Chemistry. 46: 145-146. DOI: 10.1093/Clinchem/46.2.145  0.33
2000 King GL. Activation of protein kinase C pathway, a common pathway for hyperglycemia to cause vascular pathologies American Journal of Hypertension. 13. DOI: 10.1016/S0895-7061(00)00785-8  0.332
1999 Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, ... ... King G, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 42: A1-A330. PMID 27770183 DOI: 10.1007/Bf03375458  0.388
1999 Koya D, Dennis JW, Warren CE, Takahara N, Schoen FJ, Nishio Y, Nakajima T, Lipes MA, King GL. Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 2329-37. PMID 10593880 DOI: 10.1096/Fasebj.13.15.2329  0.385
1999 Lee I, Koya D, Ishi H, Kanoh H, King GL. d-α-Tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity Diabetes Research and Clinical Practice. 45: 183-190. PMID 10588371 DOI: 10.1016/S0168-8227(99)00048-0  0.32
1999 Bursell SE, King GL. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications? Diabetes Research and Clinical Practice. 45: 169-82. PMID 10588370 DOI: 10.1016/S0168-8227(99)00047-9  0.477
1999 Bursell SE, Clermont AC, Aiello LP, Aiello LM, Schlossman DK, Feener EP, Laffel L, King GL. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care. 22: 1245-51. PMID 10480765 DOI: 10.2337/Diacare.22.8.1245  0.363
1999 Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 48: 1856-1862. PMID 10480619 DOI: 10.2337/Diabetes.48.9.1856  0.454
1999 Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL. Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. The Journal of Clinical Investigation. 104: 447-57. PMID 10449437 DOI: 10.1172/Jci5971  0.355
1999 Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 48: 1120-30. PMID 10331419 DOI: 10.2337/Diabetes.48.5.1120  0.4
1999 Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ, King GL. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. The Journal of Clinical Investigation. 103: 185-95. PMID 9916130 DOI: 10.1172/Jci3326  0.381
1999 Park JY, Ha S, King GL. The role of protein kinase C activation in the pathogenesis of diabetic vascular complications. Peritoneal Dialysis International. 19: 222-227. DOI: 10.1177/089686089901902S37  0.472
1998 Takagi H, King GL, Aiello LP. Hypoxia upregulates glucose transport activity through an adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Diabetes. 47: 1480-8. PMID 9726238 DOI: 10.2337/Diabetes.47.9.1480  0.367
1998 Schuppin GT, Pons S, Hügl S, Aiello LP, King GL, White M, Rhodes CJ. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 47: 1074-85. PMID 9648831 DOI: 10.2337/Diabetes.47.7.1074  0.337
1998 Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 47: 859-866. PMID 9604860 DOI: 10.2337/Diabetes.47.6.859  0.44
1998 Aiello LP, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R. Diabetic retinopathy. Diabetes Care. 21: 143-56. PMID 9538986 DOI: 10.2337/diacare.21.1.143  0.316
1998 Koya D, Haneda M, Kikkawa R, King GL. d‐α‐tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C‐diacylglycerol pathway Biofactors. 7: 69-76. PMID 9523030 DOI: 10.1002/Biof.5520070110  0.44
1998 Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors (Oxford, England). 7: 55-67. PMID 9523029 DOI: 10.1002/Biof.5520070109  0.414
1998 Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LEH, King GL. Vascular Endothelial Growth Factor-Induced Retinal Permeability is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform-Selective Inhibitor. Retina-the Journal of Retinal and Vitreous Diseases. 18: 492. DOI: 10.1097/00006982-199805000-00033  0.347
1997 Ishii H, Koya D, King GL. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus Journal of Molecular Medicine. 76: 21-31. PMID 9462865 DOI: 10.1007/S001090050187  0.492
1997 Caprio S, Wong S, Alberti KGMM, King G. Cardiovascular complications of diabetes Diabetologia. 40. PMID 9345652 DOI: 10.1007/Bf03168193  0.51
1997 Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 46: 1473-80. PMID 9287049 DOI: 10.2337/Diab.46.9.1473  0.415
1997 Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, Walsh RA, King GL. Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 94: 9320-5. PMID 9256480 DOI: 10.1073/PNAS.94.17.9320  0.312
1997 Feener EP, King GL. Vascular dysfunction in diabetes mellitus The Lancet. 350. PMID 9250277 DOI: 10.1016/S0140-6736(97)90022-2  0.429
1997 Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, King GL. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. Journal of Clinical Investigation. 100: 115-126. PMID 9202063 DOI: 10.1172/Jci119503  0.417
1996 King GL. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Annals of Medicine. 28: 427-432. PMID 8949974 DOI: 10.3109/07853899608999103  0.451
1996 Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth Journal of Clinical Investigation. 98: 2018-2026. PMID 8903320 DOI: 10.1172/Jci119006  0.369
1996 Sasson S, Gorowits N, Joost HG, King GL, Cerasi E, Kaiser N. Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells British Journal of Pharmacology. 117: 1318-1324. PMID 8882631 DOI: 10.1111/J.1476-5381.1996.Tb16731.X  0.35
1996 King GL, Brownlee M. The cellular and molecular mechanisms of diabetic complications Endocrinology and Metabolism Clinics of North America. 25: 255-270. PMID 8799700 DOI: 10.1016/S0889-8529(05)70324-8  0.479
1996 Feener EP, Xia P, Inoguchi T, Shiba T, Kunisaki M, King GL. Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression Contributions to Nephrology. 118: 180-187. PMID 8744056 DOI: 10.1159/000425092  0.325
1996 Takagi H, King GL, Aiello LP. Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes. 45: 1016-23. PMID 8690146 DOI: 10.2337/Diab.45.8.1016  0.393
1996 Kunisaki M, Fumio U, Nawata H, King GL. Vitamin E Normalizes Diacylglycerol—Protein Kinase C Activation Induced by Hyperglycemia in Rat Vascular Tissues Diabetes. 45. PMID 8674876 DOI: 10.2337/Diab.45.3.S117  0.388
1996 King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, Xia P. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 45. PMID 8674872 DOI: 10.2337/Diab.45.3.S105  0.438
1996 Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science (New York, N.Y.). 272: 728-31. PMID 8614835 DOI: 10.1126/Science.272.5262.728  0.424
1996 Hsueh W, Law RE, Saad M, Dy J, Feener E, King G. Insulin resistance and macrovascular disease Current Opinion in Endocrinology & Diabetes. 3: 346-354. DOI: 10.1097/00060793-199608000-00010  0.305
1996 King GL. The role of protein kinase C activation in the development of vascular disease in diabetes Current Opinion in Endocrinology & Diabetes. 3: 285-290. DOI: 10.1097/00060793-199608000-00002  0.419
1996 Ishii H, Jirousek, Koya D, Takagi C, Xia P, Clermont A, Bursell S, Kern T, Ballas L, Heath W, Stramm L, Feener E, King G. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor American Journal of Ophthalmology. 122: 291. DOI: 10.1016/S0002-9394(14)72042-2  0.403
1995 Takagi C, King GL, Clermont AC, Cummins DR, Takagi H, Bursell SE. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor. Current Eye Research. 14: 741-9. PMID 8529412 DOI: 10.3109/02713689508995795  0.381
1995 Feener EP, Northrup JM, Aiello LP, King GL. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. Journal of Clinical Investigation. 95: 1353-1362. PMID 7883982 DOI: 10.1172/Jci117786  0.353
1995 Kunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. The American Journal of Physiology. 269: E239-46. PMID 7653541 DOI: 10.1152/Ajpendo.1995.269.2.E239  0.413
1995 Xia P, Kramer RM, King GL. Identification of the mechanism for the inhibition of Na+,K+-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2 Journal of Clinical Investigation. 96: 733-740. PMID 7635966 DOI: 10.1172/Jci118117  0.366
1995 Nishio Y, Warren CE, Buczek-Thomas JA, Rulfs J, Koya D, Aiello LP, Feener EP, Miller TB, Dennis JW, King GL. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue Journal of Clinical Investigation. 96: 1759-1767. PMID 7560067 DOI: 10.1172/Jci118221  0.421
1995 Thieme H, Aiello LP, Takagi H, Ferrara N, King GL. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Diabetes. 44: 98-103. PMID 7529203 DOI: 10.2337/Diab.44.1.98  0.355
1995 Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, Ferrara N, King GL, Smith LE. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proceedings of the National Academy of Sciences of the United States of America. 92: 10457-61. PMID 7479819 DOI: 10.1073/Pnas.92.23.10457  0.345
1994 Nishio Y, Aiello LP, King GL. Glucose induced genes in bovine aortic smooth muscle cells identified by mRNA differential display The Faseb Journal. 8: 103-106. PMID 8299882 DOI: 10.1096/Fasebj.8.1.8299882  0.377
1994 King GL, Shiba T, Oliver J, Inoguchi T, Bursell SE. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annual Review of Medicine. 45: 179-88. PMID 8198375 DOI: 10.1146/Annurev.Med.45.1.179  0.452
1994 Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes. 43: 1122-9. PMID 8070612 DOI: 10.2337/Diab.43.9.1122  0.487
1994 Aiello LP, Robinson GS, Lin YW, Nishio Y, King GL. Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display Proceedings of the National Academy of Sciences of the United States of America. 91: 6231-6235. PMID 8016144 DOI: 10.1073/Pnas.91.13.6231  0.349
1994 Feener EP, Shiba T, Hu KQ, Wilden PA, White MF, King GL. Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. The Biochemical Journal. 43-50. PMID 7945263 DOI: 10.1042/Bj3030043  0.317
1994 Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. American Journal of Physiology-Endocrinology and Metabolism. 267. PMID 7943217 DOI: 10.1152/Ajpendo.1994.267.3.E369  0.441
1994 Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 43: 1372-7. PMID 7926314 DOI: 10.2337/Diab.43.11.1372  0.431
1993 Ohashi H, Rosen KM, Smith FE, Villa-Komaroff L, Nayak RC, King GL. Characterization of type I IGF receptor and IGF-I mRNA expression in cultured human and bovine glomerular cells. Regulatory Peptides. 48: 9-20. PMID 8265820 DOI: 10.1016/0167-0115(93)90331-2  0.354
1993 Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, King GL. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. The American Journal of Physiology. 265: E783-93. PMID 8238505 DOI: 10.1152/Ajpendo.1993.265.5.E783  0.365
1993 Kaiser N, Sasson S, Feener EP, Boukobza-Vardi N, Higashi S, Moller DE, Davidheiser S, Przybylski RJ, King GL. Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells Diabetes. 42: 80-89. PMID 7678404 DOI: 10.2337/Diab.42.1.80  0.316
1992 Rubia GDl, Oliver FJ, Inoguchi T, King GL. Induction of Resistance to Endothelin-1's Biochemical Actions by Elevated Glucose Levels in Retinal Pericytes Diabetes. 41: 1533-1539. PMID 1446793 DOI: 10.2337/Diabetes.41.12.1533  0.345
1992 Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation Proceedings of the National Academy of Sciences of the United States of America. 89: 11059-11063. PMID 1438315 DOI: 10.1073/Pnas.89.22.11059  0.468
1992 Bursell SE, Clermont AC, Shiba T, King GL. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Current Eye Research. 11: 287-95. PMID 1388117 DOI: 10.3109/02713689209001782  0.311
1991 King GL, Ohashi H, Najak R. A cell biology approach to the study of diabetic vascular complications. Journal of Diabetic Complications. 5: 56-57. PMID 1663116 DOI: 10.1016/0891-6632(91)90016-I  0.439
1990 Nayak RC, Attawia M, Eisenbarth GS, King GL. Are anti-glomerular antibodies associated with diabetic nephropathy? Journal of Autoimmunity. 3: 83. DOI: 10.1016/0896-8411(90)90084-6  0.365
1989 Kwok CF, Goldstein BJ, Muller-Wieland D, Lee TS, Kahn CR, King GL. Identification of persistent defects in insulin receptor structure and function capillary endothelial cells from diabetic rats. Journal of Clinical Investigation. 83: 127-136. PMID 2910904 DOI: 10.1172/Jci113848  0.46
1989 Lee T, Saltsman KA, Ohashi H, King GL. Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications Proceedings of the National Academy of Sciences of the United States of America. 86: 5141-5145. PMID 2740348 DOI: 10.1073/Pnas.86.13.5141  0.481
1989 Banskota NK, Taub R, Zellner K, King GL. Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Molecular Endocrinology (Baltimore, Md.). 3: 1183-90. PMID 2674692 DOI: 10.1210/Mend-3-8-1183  0.345
1989 Lee T, Chao T, Hu K, King GL. Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cells. Biochemical and Biophysical Research Communications. 162: 381-386. PMID 2665742 DOI: 10.1016/0006-291X(89)92008-1  0.304
1989 Lee T, Hu K, Chao T, King GL. Characterization of Endothelin Receptors and Effects of Endothelin on Diacylglycerol and Protein Kinase C in Retinal Capillary Pericytes Diabetes. 38: 1643-1646. PMID 2555243 DOI: 10.2337/Diab.38.12.1643  0.385
1989 Lee TS, MacGregor LC, Fluharty SJ, King GL. Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells. The Journal of Clinical Investigation. 83: 90-4. PMID 2536048 DOI: 10.1172/Jci113889  0.363
1989 Banskota NK, Taub R, Zellner K, Olsen P, King GL. Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I. Diabetes. 38: 123-9. PMID 2521209 DOI: 10.2337/Diab.38.1.123  0.339
1989 King GL. Molecular and Cellular Biology of Diabetes Mellitus. Volume II: Insulin Action. Boris Draznin , Shlomo Melmed , Derek LeRoith The Quarterly Review of Biology. 64: 535-535. DOI: 10.1086/416564  0.323
1989 Bottaro DP, Bonner-Weir S, King GL. Insulin Receptor Recycling in Vascular Endothelial Cells Journal of Biological Chemistry. 264: 5916-5923. DOI: 10.1016/s0021-9258(18)83637-7  0.543
1988 Arnqvist HJ, Ballermann BJ, King GL. Receptors for and effects of insulin and IGF-I in rat glomerular mesangial cells. American Journal of Physiology-Cell Physiology. 254. PMID 3279808 DOI: 10.1152/Ajpcell.1988.254.3.C411  0.333
1988 Hachiya HL, Halban PA, King GL. Intracellular pathways of insulin transport across vascular endothelial cells. American Journal of Physiology-Cell Physiology. 255. PMID 3052101 DOI: 10.1152/Ajpcell.1988.255.4.C459  0.372
1987 King GL, Berman AB, Bonner-Weir S, Carson MP. Regulation of Vascular Permeability in Cell Culture Diabetes. 36: 1460-1467. PMID 3678623 DOI: 10.2337/Diab.36.12.1460  0.403
1987 Grigorescu F, Herzberg V, King G, Meistas M, Elders J, Frazer T, Kahn CR. Defects in insulin binding and autophosphorylation of erythrocyte insulin receptors in patients with syndromes of severe insulin resistance and their parents. The Journal of Clinical Endocrinology and Metabolism. 64: 549-56. PMID 3029156 DOI: 10.1210/Jcem-64-3-549  0.351
1986 Banskota NK, Carpentier J, King GL. Processing and release of insulin and insulin-like growth factor I by macro- and microvascular endothelial cells Endocrinology. 119: 1904-1913. PMID 3533517 DOI: 10.1210/Endo-119-5-1904  0.363
1986 Hachiya HL, Carpentier JL, King GL. Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells. Diabetes. 35: 1065-1072. PMID 2944781 DOI: 10.2337/Diab.35.10.1065  0.353
1986 King GL. Hyperglycemia and the pathogenesis of diabetic retinopathy Journal of General Internal Medicine. 1: 133-134. PMID 2430081 DOI: 10.1007/Bf02599819  0.436
1985 King GL. Cell biology as an approach to the study of the vascular complications of diabetes Metabolism-Clinical and Experimental. 34: 17-24. PMID 3906357 DOI: 10.1016/S0026-0495(85)80005-6  0.445
1985 King GL, Johnson SM, Jialal I. Processing and Transport of Insulin by Vascular Endothelial Cells Effects of Sulfonylureas on Insulin Receptors The American Journal of Medicine. 79: 43-47. PMID 3901745 DOI: 10.1016/S0002-9343(85)80006-1  0.397
1985 King GL, Johnson SM. Receptor-mediated transport of insulin across endothelial cells Science. 227: 1583-1586. PMID 3883490 DOI: 10.1126/Science.3883490  0.364
1985 Jialal I, Crettaz M, Hachiya HL, Kahn CR, Moses AC, Buzney SM, King GL. Characterization of the receptors for insulin and the insulin-like growth factors on micro- and macrovascular tissues. Endocrinology. 117: 1222-1229. PMID 2990869 DOI: 10.1210/Endo-117-3-1222  0.397
1985 King GL, Goodman AD, Buzney S, Moses A, Kahn CR. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. Journal of Clinical Investigation. 75: 1028-1036. PMID 2984251 DOI: 10.1172/Jci111764  0.388
1984 Jialal I, King GL, Buchwald S, Kahn CR, Crettaz M. Processing of Insulin by Bovine Endothelial Cells in Culture: Internalization Without Degradation Diabetes. 33: 794-800. PMID 6378702 DOI: 10.2337/Diab.33.8.794  0.356
1983 King GL, Buzney SM, Kahn CR, Hetu N, Buchwald S, Macdonald SG, Rand LI. Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels. Journal of Clinical Investigation. 71: 974-979. PMID 6339562 DOI: 10.1172/Jci110852  0.414
1983 King GL, Kahn CR, Heldin CH. Sharing of biological effect and receptors between guinea pig insulin and platelet-derived growth factor Proceedings of the National Academy of Sciences of the United States of America. 80: 1308-1312. PMID 6298787 DOI: 10.1073/Pnas.80.5.1308  0.336
1981 King GL, Kahn CR. Non-parallel evolution of metabolic and growth-promoting functions of insulin Nature. 292: 644-646. PMID 7019727 DOI: 10.1038/292644A0  0.33
1981 Kahn CR, Baird KL, Flier JS, Grunfeld C, Harmon JT, Harrison LC, Karlsson FA, Kasuga M, King GL, Lang UC, Podskalny JM, Van Obberghen E. Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Progress in Hormone Research. 37: 477-538. PMID 6269165 DOI: 10.1016/B978-0-12-571137-1.50015-3  0.346
1981 Rechler MM, Nissley SP, King GL, Moses AC, Obberghen-Schilling EEV, Romanus JA, Knight AB, Short PA, White RM. Multiplication stimulating activity (MSA) from the BRL 3A rat liver cell line: relation to human somatomedins and insulin. Journal of Supramolecular Structure and Cellular Biochemistry. 15: 253-286. PMID 6267316 DOI: 10.1002/Jsscb.1981.380150305  0.335
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