| Year |
Citation |
Score |
| 2023 |
Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, et al. Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2205993. PMID 37066759 DOI: 10.1002/advs.202205993 |
0.316 |
|
| 2022 |
Zhang C, Wang X, Zhang C. Icaritin inhibits CDK2 expression and activity to interfere with tumor progression. Iscience. 25: 104991. PMID 36093042 DOI: 10.1016/j.isci.2022.104991 |
0.305 |
|
| 2022 |
Zhang C, Zhang HL, Liu SL, Yang JM, Gao FH. P62/SQSTM1 mediates the autophagy-lysosome degradation of CDK2 protein undergoing PI3Kα/AKT inhibition. Biochemical and Biophysical Research Communications. 627: 5-11. PMID 36007335 DOI: 10.1016/j.bbrc.2022.08.034 |
0.344 |
|
| 2022 |
Rezende Miranda R, Zhang C. Reactivity-based chemical-genetic study of protein kinases. Rsc Medicinal Chemistry. 13: 783-797. PMID 35923719 DOI: 10.1039/d1md00389e |
0.511 |
|
| 2022 |
Wan D, Han X, Zhang C, Zhang Y, Ma Y, Wang G. EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway. Clinical and Experimental Pharmacology & Physiology. PMID 35818168 DOI: 10.1111/1440-1681.13701 |
0.335 |
|
| 2022 |
Zhang C, Zhao W, Duvall SW, Kowallis KA, Childers WS. Regulation of the activity of bacterial histidine kinase PleC by the scaffolding protein PodJ. The Journal of Biological Chemistry. 101683. PMID 35124010 DOI: 10.1016/j.jbc.2022.101683 |
0.412 |
|
| 2021 |
Zhao F, Kim W, Gao H, Liu C, Zhang Y, Chen Y, Deng M, Zhou Q, Huang J, Hu Q, Chen SH, Nowsheen S, Kloeber JA, Qin B, Yin P, ... ... Zhang C, et al. ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection. Nature Cell Biology. PMID 34354233 DOI: 10.1038/s41556-021-00723-9 |
0.414 |
|
| 2021 |
Parker N, Laychur A, Sukwani M, Orwig KE, Oatley JM, Zhang C, Rutaganira FU, Shokat K, Wright WW. Spermatogonial Stem Cell Numbers Are Reduced by Transient Inhibition of GDNF Signaling but Restored by Self-Renewing Replication when Signaling Resumes. Stem Cell Reports. PMID 33636117 DOI: 10.1016/j.stemcr.2021.01.015 |
0.743 |
|
| 2021 |
Lee L, Hizukuri Y, Severson P, Powell B, Zhang C, Ma Y, Narahara M, Sumi H, Hernandez D, Rajkhowa T, Bollag G, Levis M. A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia. Haematologica. PMID 33504139 DOI: 10.1182/Blood-2019-124030 |
0.345 |
|
| 2020 |
Zhang C, Smalley I, Emmons MF, Sharma R, Izumi V, Messina J, Koomen JM, Pasquale EB, Forsyth PA, Smalley KSM. Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma. The Journal of Investigative Dermatology. PMID 32890629 DOI: 10.1016/J.Jid.2020.08.012 |
0.351 |
|
| 2020 |
Zhang F, Ma L, Zhang C, Du G, Shen Y, Tang D, Li Y, Yu H, Ma B, Cheng Z. The SUN domain proteins OsSUN1 and OsSUN2 play critical but partially redundant roles in meiosis. Plant Physiology. PMID 32554471 DOI: 10.1104/Pp.20.00140 |
0.322 |
|
| 2020 |
Smith CC, Levis MJ, Frankfurt O, Pagel JM, Roboz GJ, Stone RM, Wang ES, Severson PL, West BL, Le MH, Kayser S, Lam B, Hsu HH, Zhang C, Bollag G, et al. A phase 1/2 study of the oral FLT3 inhibitor pexidartinib in relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia. Blood Advances. 4: 1711-1721. PMID 32330242 DOI: 10.1182/Bloodadvances.2020001449 |
0.329 |
|
| 2020 |
Han XR, Chen L, Wei Y, Yu W, Chen Y, Zhang C, Jiao B, Shi T, Sun L, Zhang C, Xu Y, Lee MR, Luo Y, Plewe MB, Wang J. Discovery of Selective Small Molecule Degraders of BRAF-V600E. Journal of Medicinal Chemistry. PMID 32223235 DOI: 10.1021/Acs.Jmedchem.9B02083 |
0.481 |
|
| 2020 |
Yang H, Lin Q, Zhang C, Yu X, Cheng Z, Li G, Hu Q, Ren X, Zhang Q, Liu J, He C. Carbon dioxide electroreduction on single-atom nickel decorated carbon membranes with industry compatible current densities. Nature Communications. 11: 593. PMID 32001699 DOI: 10.1038/s41467-020-14402-0 |
0.355 |
|
| 2019 |
Sohretoglu D, Zhang C, Luo J, Huang S. ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells. Signal Transduction and Targeted Therapy. 4: 21. PMID 31637001 DOI: 10.1038/s41392-019-0056-7 |
0.364 |
|
| 2019 |
Wang YN, Lu YX, Liu J, Jin Y, Bi HC, Zhao Q, Liu ZX, Li YQ, Hu JJ, Sheng H, Jiang YM, Zhang C, Tian F, Chen Y, Pan ZZ, et al. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation. Oncogene. PMID 31530934 DOI: 10.1038/S41388-019-1004-2 |
0.311 |
|
| 2019 |
Liu J, Yao Q, Xiao L, Li F, Ma W, Zhang Z, Xie X, Yang C, Cui Q, Tian Y, Zhang C, Lai B, Wang N. APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. Journal of Cellular Physiology. PMID 31489637 DOI: 10.1002/Jcp.29156 |
0.322 |
|
| 2019 |
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. Acs Medicinal Chemistry Letters. 10: 1074-1080. PMID 31312411 DOI: 10.1021/Acsmedchemlett.9B00194 |
0.502 |
|
| 2019 |
Huang Q, Mayaka JB, Zhong Q, Zhang C, Hou G, Ni J, Shen Y. Phosphorylation of the Archaeal Holliday Junction Resolvase Hjc Inhibits Its Catalytic Activity and Facilitates DNA Repair in REY15A. Frontiers in Microbiology. 10: 1214. PMID 31214148 DOI: 10.3389/fmicb.2019.01214 |
0.322 |
|
| 2019 |
Ni F, Ekanayake A, Espinosa B, Yu C, Sanders JN, Perino J, Houk KN, Zhang C. Synthesis and Target Identification of a Novel Electrophilic Warhead, 2-Chloromethylquinoline. Biochemistry. PMID 31181899 DOI: 10.1021/Acs.Biochem.9B00359 |
0.344 |
|
| 2019 |
Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, et al. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Nature Communications. 10: 1870. PMID 31015455 DOI: 10.1038/S41467-019-09844-0 |
0.458 |
|
| 2019 |
He LJ, Zhu YB, Fan QZ, Miao DD, Zhang SP, Liu XP, Zhang C. Shape-based virtual screen for the discovery of novel CDK8 inhibitor chemotypes. Bioorganic & Medicinal Chemistry Letters. PMID 30630717 DOI: 10.1016/j.bmcl.2018.12.065 |
0.323 |
|
| 2018 |
Yao Z, Gao Y, Su W, Yaeger R, Tao J, Na N, Zhang Y, Zhang C, Rymar A, Tao A, Timaul NM, Mcgriskin R, Outmezguine NA, Zhao H, Chang Q, et al. RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling. Nature Medicine. PMID 30559419 DOI: 10.1038/S41591-018-0274-5 |
0.392 |
|
| 2018 |
Gebreyohannes YK, Burton EA, Wozniak A, Matusow B, Habets G, Wellens J, Cornillie J, Lin J, Nespi M, Wu G, Zhang C, Bollag G, Debiec-Rychter M, Sciot R, Schöffski P. PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors. Clinical and Experimental Medicine. PMID 30523507 DOI: 10.1007/S10238-018-0541-2 |
0.409 |
|
| 2018 |
Zhang C, Shen Y, Tang D, Shi W, Zhang D, Du G, Zhou Y, Liang G, Li Y, Cheng Z. The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice. Plos Genetics. 14: e1007769. PMID 30419020 DOI: 10.1371/Journal.Pgen.1007769 |
0.301 |
|
| 2018 |
Liu W, Guo W, Zhu Y, Peng S, Zheng W, Zhang C, Shao F, Zhu Y, Hang N, Kong L, Meng X, Xu Q, Sun Y. Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 30185517 DOI: 10.4049/Jimmunol.1700796 |
0.332 |
|
| 2018 |
Chen J, Cai Z, Bai M, Yu X, Zhang C, Cao C, Hu X, Wang L, Su R, Wang D, Wang L, Yao Y, Ye R, Hou B, Yu Y, et al. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Research. PMID 30143796 DOI: 10.1038/S41422-018-0076-9 |
0.3 |
|
| 2018 |
Giricz O, Mo Y, Dahlman KB, Cotto-Rios XM, Vardabasso C, Nguyen H, Matusow B, Bartenstein M, Polishchuk V, Johnson DB, Bhagat TD, Shellooe R, Burton E, Tsai J, Zhang C, et al. The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma. Jci Insight. 3. PMID 30046005 DOI: 10.1172/Jci.Insight.120422 |
0.302 |
|
| 2018 |
Zhu C, Xia L, Li F, Zhou L, Weng Q, Li Z, Wu Y, Mao Y, Zhang C, Wu Y, Li M, Ying S, Chen Z, Shen H, Li W. mTOR complexes differentially orchestrates eosinophil development in allergy. Scientific Reports. 8: 6883. PMID 29720621 DOI: 10.1038/S41598-018-25358-Z |
0.331 |
|
| 2018 |
Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C. Effects of rigidity on the selectivity of protein kinase inhibitors. European Journal of Medicinal Chemistry. 146: 519-528. PMID 29407977 DOI: 10.1016/J.Ejmech.2018.01.053 |
0.462 |
|
| 2018 |
Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, ... ... Zhang C, et al. BRD4 profiling identifies critical Chronic Lymphocytic Leukemia oncogenic circuits and reveals sensitivity to PLX51107, a novel structurally distinct BET inhibitor. Cancer Discovery. PMID 29386193 DOI: 10.1158/2159-8290.Cd-17-0902 |
0.356 |
|
| 2018 |
Janku F, Vaishampayan UN, Khemka V, Bhatty M, Sherman EJ, Tao J, Whisenant JR, Hong DS, Bui N, Kummar S, Feun LG, Parikh AR, Zhang C, Michelson G, Martin E, et al. Phase 1/2 precision medicine study of the next-generation BRAF inhibitor PLX8394. Journal of Clinical Oncology. 36: 2583-2583. DOI: 10.1200/Jco.2018.36.15_Suppl.2583 |
0.304 |
|
| 2017 |
Chen X, Wang R, Liu X, Wu Y, Zhou T, Yang Y, Perez A, Chen YC, Hu L, Chadarevian JP, Assadieskandar A, Zhang C, Ying QL. A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate. Developmental Cell. 43: 563-576.e4. PMID 29207259 DOI: 10.1016/J.Devcel.2017.11.007 |
0.335 |
|
| 2017 |
Chen X, Wang R, Liu X, Wu Y, Zhou T, Yang Y, Perez A, Chen YC, Hu L, Chadarevian JP, Assadieskandar A, Zhang C, Ying QL. A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate. Developmental Cell. 43: 563-576.e4. PMID 29207259 DOI: 10.1016/J.Devcel.2017.11.007 |
0.335 |
|
| 2017 |
Du WW, Zhang C, Yang W, Yong T, Awan FM, Yang BB. Identifying and Characterizing circRNA-Protein Interaction. Theranostics. 7: 4183-4191. PMID 29158818 DOI: 10.7150/Thno.21299 |
0.306 |
|
| 2017 |
Ni F, Kung A, Duan Y, Shah V, Amador C, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C. Remarkably stereospecific utilization of ATP α,β-halomethylene analogues by protein kinases. Journal of the American Chemical Society. PMID 28535041 DOI: 10.1021/Jacs.7B03266 |
0.317 |
|
| 2017 |
Liu KH, Niu Y, Konishi M, Wu Y, Du H, Sun Chung H, Li L, Boudsocq M, McCormack M, Maekawa S, Ishida T, Zhang C, Shokat K, Yanagisawa S, Sheen J. Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature. PMID 28489820 DOI: 10.1038/Nature22077 |
0.531 |
|
| 2017 |
Kung A, Schimpl M, Ekanayake AI, Chen YC, Overman R, Zhang C. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. Acs Chemical Biology. PMID 28459525 DOI: 10.1021/Acschembio.6B01083 |
0.511 |
|
| 2017 |
Zhang C, Chen Y, Gan X, Huang Z, Zou M, Fu W, Xing W, Xu D. SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways. International Journal of Molecular Sciences. 18. PMID 28422048 DOI: 10.3390/ijms18040835 |
0.332 |
|
| 2017 |
Zhang C, Bollag G. Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization. Cancer Discovery. 7: 356-358. PMID 28373167 DOI: 10.1158/2159-8290.Cd-17-0172 |
0.354 |
|
| 2017 |
Zhang C, Wang S, Li J, Zhang W, Zheng L, Yang C, Zhu T, Rong R. The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury. Cell Death & Disease. 8: e2695. PMID 28333137 DOI: 10.1038/Cddis.2017.86 |
0.309 |
|
| 2017 |
Karoulia Z, Wu Y, Ahmed TA, Xin Q, Bollard J, Krepler C, Wu X, Zhang C, Bollag G, Herlyn M, Fagin JA, Lujambio A, Gavathiotis E, Poulikakos PI. Abstract 1225: A unified model of RAF inhibitor action determines inhibitor activity in BRAF-dependent tumors Cancer Research. 77: 1225-1225. DOI: 10.1158/1538-7445.Am2017-1225 |
0.319 |
|
| 2016 |
Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C. Covalent Modulators of the Vacuolar ATPase. Journal of the American Chemical Society. PMID 28010062 DOI: 10.1021/Jacs.6B12511 |
0.317 |
|
| 2016 |
Wu YP, Wu YF, Zhang C, Zhou HB, Cao C, Li M, Zhu C, Ying SM, Chen ZH, Shen HH, Li W. Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1. The American Journal of Pathology. PMID 27912076 DOI: 10.1016/J.Ajpath.2016.10.012 |
0.308 |
|
| 2016 |
Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P. A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell Host & Microbe. PMID 27866900 DOI: 10.1016/J.Chom.2016.10.011 |
0.305 |
|
| 2016 |
Hu Y, Lou J, Mao YY, Lai TW, Liu LY, Zhu C, Zhang C, Liu J, Li YY, Zhang F, Li W, Ying SM, Chen ZH, Shen HH. Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy. 0. PMID 27658023 DOI: 10.1080/15548627.2016.1230584 |
0.34 |
|
| 2016 |
Karoulia Z, Wu Y, Ahmed TA, Xin Q, Bollard J, Krepler C, Wu X, Zhang C, Bollag G, Herlyn M, Fagin JA, Lujambio A, Gavathiotis E, Poulikakos PI. An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. Cancer Cell. 30: 501-503. PMID 27622340 DOI: 10.1016/J.Ccell.2016.08.008 |
0.359 |
|
| 2016 |
Chen YC, Zhang C. A chemoproteomic method for identifying cellular targets of covalent kinase inhibitors. Genes & Cancer. 7: 148-53. PMID 27551330 DOI: 10.18632/genesandcancer.106 |
0.374 |
|
| 2016 |
Karoulia Z, Wu Y, Ahmed TA, Xin Q, Bollard J, Krepler C, Wu X, Zhang C, Bollag G, Herlyn M, Fagin JA, Lujambio A, Gavathiotis E, Poulikakos PI. An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. Cancer Cell. PMID 27523909 DOI: 10.1016/J.Ccell.2016.06.024 |
0.382 |
|
| 2016 |
Kung A, Chen YC, Schimpl M, Ni F, Zhu J, Turner M, Molina H, Overman R, Zhang C. Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3. Journal of the American Chemical Society. PMID 27478969 DOI: 10.1021/Jacs.6B05483 |
0.493 |
|
| 2016 |
Lin J, Zhang Y, Matusow B, Mumy A, Tsang G, Zhang J, Powers H, Spevak W, Severson P, Tsai J, Bollag G, Zhang C. A Mixed Type 1 and Type 2 Kinase Inhibitor That Overrides FLT3 F691 and D835 Resistance Mutations Blood. 128: 1074-1074. DOI: 10.1182/Blood.V128.22.1074.1074 |
0.317 |
|
| 2016 |
Ma Y, Powell B, Zhang J, Zhang Y, Carias H, Schwertschlag U, Habets G, Ibrahim P, Spevak W, Zhang C, Bollag G. Abstract 4711: Broad anti-tumor activity of a novel BET bromodomain inhibitor Cancer Research. 76: 4711-4711. DOI: 10.1158/1538-7445.Am2016-4711 |
0.304 |
|
| 2015 |
Zhang C, Kung A, Liu X, Prakash GK, Malinoski B. Development of Alkyne-Containing Pyrazolopyrimidines to Overcome Drug Resistance of Bcr-Abl Kinase. Journal of Medicinal Chemistry. PMID 26562217 DOI: 10.1021/Acs.Jmedchem.5B01125 |
0.309 |
|
| 2015 |
Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. PMID 26466569 DOI: 10.1038/Nature14982 |
0.354 |
|
| 2015 |
Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, et al. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discovery. 5: 668-79. PMID 25847190 DOI: 10.1158/2159-8290.Cd-15-0060 |
0.313 |
|
| 2015 |
Yao TJ, Zhu JH, Peng F, Cui Z, Zhang C, Lu PH. AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 25691251 DOI: 10.1007/s13277-015-3237-1 |
0.321 |
|
| 2014 |
Mantilla CB, Stowe JM, Sieck DC, Ermilov LG, Greising SM, Zhang C, Shokat KM, Sieck GC. TrkB kinase activity maintains synaptic function and structural integrity at adult neuromuscular junctions. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 910-20. PMID 25170066 DOI: 10.1152/Japplphysiol.01386.2013 |
0.602 |
|
| 2014 |
Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 3: e03245. PMID 25161195 DOI: 10.7554/Elife.03245 |
0.459 |
|
| 2014 |
Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature Immunology. 15: 186-94. PMID 24317039 DOI: 10.1038/Ni.2772 |
0.648 |
|
| 2014 |
Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF. Author response: Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity Elife. DOI: 10.7554/Elife.03245.021 |
0.412 |
|
| 2014 |
Sekulic A, Weeraratna AT, MacKeigan JL, Kaur A, O'Connell M, Goodall ML, Barrett M, Lenkiewitz E, Holley T, Zismann V, Gordon M, Bollag G, Zhang C, Trent JM. Abstract LB-213: Discovery and molecular modeling of a novel mutation in the vemurafenib binding site of BRAF associated with therapeutic resistance in a patient with metastatic melanoma Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-213 |
0.315 |
|
| 2013 |
Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8. PMID 23841803 DOI: 10.1021/Cb400376P |
0.841 |
|
| 2013 |
Zhang W, Luo JG, Zhang C, Kong LY. Different apoptotic effects of triterpenoid saponin-rich Gypsophila oldhamiana root extract on human hepatoma SMMC-7721 and normal human hepatic L02 cells. Biological & Pharmaceutical Bulletin. 36: 1080-7. PMID 23811557 DOI: 10.1248/bpb.b12-01069 |
0.301 |
|
| 2013 |
Shieh A, Ward AF, Donlan KL, Harding-Theobald ER, Xu J, Mullighan CG, Zhang C, Chen SC, Su X, Downing JR, Bollag GE, Shannon KM. Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo. Blood. 121: 4884-93. PMID 23637129 DOI: 10.1182/Blood-2012-05-432252 |
0.303 |
|
| 2013 |
Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Molecular Cell. 50: 250-60. PMID 23622515 DOI: 10.1016/J.Molcel.2013.04.003 |
0.64 |
|
| 2013 |
Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 110: 5689-94. PMID 23493555 DOI: 10.1073/Pnas.1219457110 |
0.316 |
|
| 2013 |
Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. Journal of Medicinal Chemistry. 56: 3068-77. PMID 23470217 DOI: 10.1021/Jm4001314 |
0.734 |
|
| 2012 |
Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. 15: 1645-54. PMID 23143520 DOI: 10.1038/Nn.3249 |
0.651 |
|
| 2012 |
Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nature Structural & Molecular Biology. 19: 1108-15. PMID 23064645 DOI: 10.1038/Nsmb.2399 |
0.702 |
|
| 2012 |
Bollag G, Tsai J, Zhang J, Zhang C, Ibrahim P, Nolop K, Hirth P. Vemurafenib: the first drug approved for BRAF -mutant cancer Nature Reviews Drug Discovery. 11: 873-886. PMID 23060265 DOI: 10.1038/Nrd3847 |
0.3 |
|
| 2012 |
Hou X, Shen Y, Zhang C, Zhang L, Qin Y, Yu Y, Wang L, Sun X. A specific oligodeoxynucleotide promotes the differentiation of osteoblasts via ERK and p38 MAPK pathways. International Journal of Molecular Sciences. 13: 7902-14. PMID 22942680 DOI: 10.3390/ijms13077902 |
0.351 |
|
| 2012 |
Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. Plos Genetics. 8: e1002935. PMID 22927831 DOI: 10.1371/Journal.Pgen.1002935 |
0.742 |
|
| 2012 |
Zhang C, Sun X, Ren Y, Lou Y, Zhou J, Liu M, Li D. Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Cancer Biology & Therapy. 13: 1214-20. PMID 22892842 DOI: 10.4161/cbt.21412 |
0.314 |
|
| 2012 |
Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. Plos Genetics. 8: e1002822. PMID 22876190 DOI: 10.1371/Journal.Pgen.1002822 |
0.538 |
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| 2012 |
Young ET, Zhang C, Shokat KM, Parua PK, Braun KA. The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 287: 29021-34. PMID 22761425 DOI: 10.1074/Jbc.M112.380147 |
0.547 |
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| 2012 |
Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Molecular Biology of the Cell. 23: 2388-98. PMID 22535525 DOI: 10.1091/Mbc.E12-03-0209 |
0.583 |
|
| 2012 |
St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP. Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Molecular and Cellular Biology. 32: 2372-83. PMID 22508988 DOI: 10.1128/Mcb.06657-11 |
0.589 |
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| 2012 |
Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proceedings of the National Academy of Sciences of the United States of America. 109: E1019-27. PMID 22474407 DOI: 10.1073/Pnas.1111317109 |
0.666 |
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| 2012 |
Hengeveld RC, Hertz NT, Vromans MJ, Zhang C, Burlingame AL, Shokat KM, Lens SM. Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Molecular & Cellular Proteomics : McP. 11: 47-59. PMID 22267324 DOI: 10.1074/Mcp.M111.013912 |
0.806 |
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| 2012 |
Savitt J, Singh D, Zhang C, Chen LC, Folmer J, Shokat KM, Wright WW. The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells (Dayton, Ohio). 30: 732-40. PMID 22232066 DOI: 10.1002/Stem.1028 |
0.533 |
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| 2012 |
Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X, Tallon LJ, Sadzewicz LD, Pratap A, Ott S, Sengamalay N, Jones KM, Barrick C, Fulgenzi G, Becker J, Voelker K, ... Zhang C, et al. Genetic deletion of trkB.T1 increases neuromuscular function. American Journal of Physiology. Cell Physiology. 302: C141-53. PMID 21865582 DOI: 10.1152/Ajpcell.00469.2010 |
0.517 |
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| 2011 |
Cipak L, Zhang C, Kovacikova I, Rumpf C, Miadokova E, Shokat KM, Gregan J. Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle (Georgetown, Tex.). 10: 3527-32. PMID 22030861 DOI: 10.4161/Cc.10.20.17792 |
0.677 |
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| 2011 |
Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, ... ... Zhang C, et al. The Cryptosporidium parvum kinome. Bmc Genomics. 12: 478. PMID 21962082 DOI: 10.1186/1471-2164-12-478 |
0.637 |
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| 2011 |
Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Science Signaling. 4: ra59. PMID 21917715 DOI: 10.1126/Scisignal.2001893 |
0.571 |
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| 2011 |
Yoshii A, Murata Y, Kim J, Zhang C, Shokat KM, Constantine-Paton M. TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11894-904. PMID 21849550 DOI: 10.1523/Jneurosci.2190-11.2011 |
0.541 |
|
| 2011 |
Salomon D, Zhang C, Shokat KM, Sessa G. Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods in Molecular Biology (Clifton, N.J.). 779: 185-97. PMID 21837567 DOI: 10.1007/978-1-61779-264-9_10 |
0.63 |
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| 2011 |
Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biology. 9: 48. PMID 21729334 DOI: 10.1186/1741-7007-9-48 |
0.621 |
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| 2011 |
Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. Structural and functional basis for RNA cleavage by Ire1. Bmc Biology. 9: 47. PMID 21729333 DOI: 10.1186/1741-7007-9-47 |
0.553 |
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| 2011 |
Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Molecular Cell. 42: 624-36. PMID 21658603 DOI: 10.1016/J.Molcel.2011.03.031 |
0.758 |
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| 2011 |
Ma Y, Zhang C, Habets G, Burton EA, Wong B, Nguyen H, Spevak W, zhang J, Cho H, Wu G, Lin JL, Ewing T, Zhang Y, Shi S, Nespi M, et al. Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A229 |
0.316 |
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| 2010 |
Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Current Protocols in Chemical Biology. 2: 15-36. PMID 23836541 DOI: 10.1002/9780470559277.Ch090201 |
0.797 |
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| 2010 |
Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, et al. Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Science Signaling. 3: rs4. PMID 21177495 DOI: 10.1126/Scisignal.2001182 |
0.663 |
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| 2010 |
Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nature Immunology. 11: 1085-92. PMID 21037577 DOI: 10.1038/Ni.1955 |
0.622 |
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| 2010 |
Chou WH, Wang D, McMahon T, Qi ZH, Song M, Zhang C, Shokat KM, Messing RO. GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13955-65. PMID 20962217 DOI: 10.1523/Jneurosci.0270-10.2010 |
0.518 |
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| 2010 |
Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 467: 596-9. PMID 20823850 DOI: 10.1038/Nature09454 |
0.35 |
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| 2010 |
Tap WD, Gong KW, Dering J, Tseng Y, Ginther C, Pauletti G, Glaspy JA, Essner R, Bollag G, Hirth P, Zhang C, Slamon DJ. Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma. Neoplasia (New York, N.Y.). 12: 637-49. PMID 20689758 DOI: 10.1593/Neo.10414 |
0.318 |
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| 2010 |
Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. The Journal of Cell Biology. 190: 89-100. PMID 20624902 DOI: 10.1083/Jcb.201001050 |
0.665 |
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| 2010 |
Chai B, Li JY, Zhang W, Wu X, Zhang C, Mulholland MW. Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling Peptides. 31: 1888-1893. PMID 20603172 DOI: 10.1016/j.peptides.2010.06.028 |
0.328 |
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| 2010 |
Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Molecular Biosystems. 6: 1389-402. PMID 20582381 DOI: 10.1039/C003917A |
0.822 |
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| 2010 |
Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 465: 359-62. PMID 20485436 DOI: 10.1038/Nature09022 |
0.61 |
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| 2010 |
Sliedrecht T, Zhang C, Shokat KM, Kops GJ. Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. Plos One. 5: e10251. PMID 20422024 DOI: 10.1371/Journal.Pone.0010251 |
0.494 |
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| 2010 |
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 464: 427-30. PMID 20179705 DOI: 10.1038/Nature08902 |
0.614 |
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| 2010 |
Poulikakos PI, Zhang C, Joseph EW, Persaud Y, Pratilas CA, Bollag G, Solit DB, Shokat KM, Rosen N. Abstract LB-190: RAF inhibitors transactivate RAF dimers and ERK signaling in a wild-type BRAF-dependent manner Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-190 |
0.487 |
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| 2009 |
Zhang C, Bollag G. Scaffold-based design of kinase inhibitors for cancer therapy. Current Opinion in Genetics & Development. 20: 79-86. PMID 19932020 DOI: 10.1016/J.Gde.2009.10.010 |
0.326 |
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| 2009 |
Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Molecular and Cellular Biology. 29: 5455-64. PMID 19667075 DOI: 10.1128/Mcb.00637-09 |
0.602 |
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| 2009 |
Liu Y, Warfield L, Zhang C, Luo J, Allen J, Lang WH, Ranish J, Shokat KM, Hahn S. Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Molecular and Cellular Biology. 29: 4852-63. PMID 19581288 DOI: 10.1128/Mcb.00609-09 |
0.77 |
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| 2009 |
Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. Plos Biology. 7: e1000111. PMID 19468302 DOI: 10.1371/Journal.Pbio.1000111 |
0.636 |
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| 2009 |
Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. Inhibitor hijacking of Akt activation. Nature Chemical Biology. 5: 484-93. PMID 19465931 DOI: 10.1038/Nchembio.183 |
0.759 |
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| 2009 |
Salomon D, Bonshtien A, Mayrose M, Zhang C, Shokat KM, Sessa G. Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. The Journal of Biological Chemistry. 284: 15289-98. PMID 19332544 DOI: 10.1074/Jbc.M809724200 |
0.695 |
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| 2009 |
Viladevall L, St Amour CV, Rosebrock A, Schneider S, Zhang C, Allen JJ, Shokat KM, Schwer B, Leatherwood JK, Fisher RP. TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Molecular Cell. 33: 738-51. PMID 19328067 DOI: 10.1016/J.Molcel.2009.01.029 |
0.741 |
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| 2009 |
Zhang C, Yang N, Yang CH, Ding HS, Luo C, Zhang Y, Wu MJ, Zhang XW, Shen X, Jiang HL, Meng LH, Ding J. S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton. Plos One. 4: e4881. PMID 19293927 DOI: 10.1371/Journal.Pone.0004881 |
0.313 |
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| 2009 |
Miller AL, Zhang C, Shokat KM, Lowell CA. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 988-98. PMID 19124742 DOI: 10.4049/Jimmunol.182.2.988 |
0.651 |
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| 2009 |
Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. The unfolded protein response signals through high-order assembly of Ire1. Nature. 457: 687-93. PMID 19079236 DOI: 10.1038/Nature07661 |
0.628 |
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| 2009 |
Huskey NE, Horiuchi D, Kusdra L, Zhang C, Shokat K, Goga A. Abstract C68: Using a chemical genetic approach to define the role of CDK2 in normal and transformed cell lines Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-C68 |
0.605 |
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| 2008 |
Morgan DJ, Weisenhaus M, Shum S, Su T, Zheng R, Zhang C, Shokat KM, Hille B, Babcock DF, McKnight GS. Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proceedings of the National Academy of Sciences of the United States of America. 105: 20740-5. PMID 19074277 DOI: 10.1073/Pnas.0810971105 |
0.65 |
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| 2008 |
Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP. Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Molecular Cell. 32: 662-72. PMID 19061641 DOI: 10.1016/J.Molcel.2008.10.022 |
0.763 |
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| 2008 |
Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11890-9. PMID 19005054 DOI: 10.1523/Jneurosci.3156-08.2008 |
0.457 |
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| 2008 |
Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Molecular Cell. 32: 394-405. PMID 18995837 DOI: 10.1016/J.Molcel.2008.09.017 |
0.646 |
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| 2008 |
Shirra MK, McCartney RR, Zhang C, Shokat KM, Schmidt MC, Arndt KM. A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. The Journal of Biological Chemistry. 283: 35889-98. PMID 18955495 DOI: 10.1074/Jbc.M805325200 |
0.608 |
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| 2008 |
Kurischko C, Kuravi VK, Wannissorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffery JM, Luca FC. The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Molecular Biology of the Cell. 19: 5559-78. PMID 18843045 DOI: 10.1091/Mbc.E08-05-0455 |
0.591 |
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| 2008 |
Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Development. 3: 23. PMID 18808695 DOI: 10.1186/1749-8104-3-23 |
0.545 |
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| 2008 |
Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. The European Journal of Neuroscience. 28: 997-1002. PMID 18671735 DOI: 10.1111/J.1460-9568.2008.06383.X |
0.477 |
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| 2008 |
Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nature Chemical Biology. 4: 498-506. PMID 18622389 DOI: 10.1038/Nchembio.100 |
0.538 |
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| 2008 |
Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y. Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. Journal of Molecular Biology. 381: 540-9. PMID 18588899 DOI: 10.1016/J.Jmb.2008.06.028 |
0.526 |
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| 2008 |
Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Experimental Cell Research. 314: 2299-312. PMID 18514190 DOI: 10.1016/J.Yexcr.2008.04.006 |
0.775 |
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| 2008 |
Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. The Journal of Biological Chemistry. 283: 15419-30. PMID 18378687 DOI: 10.1074/Jbc.M709000200 |
0.61 |
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| 2008 |
Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, ... ... Zhang C, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proceedings of the National Academy of Sciences of the United States of America. 105: 3041-6. PMID 18287029 DOI: 10.1073/Pnas.0711741105 |
0.353 |
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| 2008 |
Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes & Development. 22: 386-97. PMID 18245450 DOI: 10.1101/Gad.1626408 |
0.608 |
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| 2008 |
Rubenstein EM, McCartney RR, Zhang C, Shokat KM, Shirra MK, Arndt KM, Schmidt MC. Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. The Journal of Biological Chemistry. 283: 222-30. PMID 17991748 DOI: 10.1074/Jbc.M707957200 |
0.593 |
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| 2008 |
Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities (Nature Chemical Biology (2008) 4, (498-506)) Nature Chemical Biology. 4: 632. DOI: 10.1038/Nchembio1008-632 |
0.441 |
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| 2007 |
Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chemistry & Biology. 14: 1261-72. PMID 18022565 DOI: 10.1016/J.Chembiol.2007.09.011 |
0.852 |
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| 2007 |
Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, Nasmyth K, Shokat KM. Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nature Protocols. 2: 2996-3000. PMID 18007635 DOI: 10.1038/Nprot.2007.447 |
0.687 |
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| 2007 |
Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science (New York, N.Y.). 318: 944-9. PMID 17991856 DOI: 10.1126/Science.1146361 |
0.503 |
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| 2007 |
Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/Pnas.0707782104 |
0.552 |
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| 2007 |
Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO. Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. The Journal of Biological Chemistry. 282: 33052-63. PMID 17875639 DOI: 10.1074/Jbc.M707233200 |
0.526 |
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| 2007 |
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molecular Cell. 25: 839-50. PMID 17386261 DOI: 10.1016/J.Molcel.2007.02.003 |
0.643 |
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| 2007 |
Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV. Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4383-8. PMID 17360533 DOI: 10.1073/Pnas.0701140104 |
0.636 |
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| 2007 |
Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology. 3: 229-38. PMID 17334377 DOI: 10.1038/Nchembio866 |
0.84 |
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| 2007 |
Holder S, Zemskova M, Zhang C, Tabrizizad M, Bremer R, Neidigh JW, Lilly MB. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Molecular Cancer Therapeutics. 6: 163-72. PMID 17218638 DOI: 10.1158/1535-7163.Mct-06-0397 |
0.364 |
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| 2007 |
Zhang C, Shokat KM. Enhanced selectivity for inhibition of analog-sensitive protein kinases through scaffold optimization Tetrahedron. 63: 5832-5838. DOI: 10.1016/J.Tet.2007.02.089 |
0.692 |
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| 2006 |
Wan L, Zhang C, Shokat KM, Hollingsworth NM. Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics. 174: 1767-74. PMID 17057233 DOI: 10.1534/Genetics.106.064303 |
0.637 |
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| 2006 |
Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/J.Molcel.2006.07.028 |
0.607 |
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| 2006 |
Wei F, Wang GD, Zhang C, Shokat KM, Wang H, Tsien JZ, Liauw J, Zhuo M. Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Molecular Pain. 2: 21. PMID 16776832 DOI: 10.1186/1744-8069-2-21 |
0.531 |
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| 2006 |
Wang W, Marimuthu A, Tsai J, Kumar A, Krupka HI, Zhang C, Powell B, Suzuki Y, Nguyen H, Tabrizizad M, Luu C, West BL. Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 103: 3563-8. PMID 16537444 DOI: 10.1073/Pnas.0600048103 |
0.376 |
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| 2006 |
Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Molecular Cell. 21: 701-10. PMID 16507367 DOI: 10.1016/J.Molcel.2006.01.018 |
0.555 |
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| 2005 |
Ding H, Zhang C, Wu X, Yang C, Zhang X, Ding J, Xie Y. Novel indole alpha-methylene-gamma-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases. Bioorganic & Medicinal Chemistry Letters. 15: 4799-802. PMID 16143526 DOI: 10.1016/J.Bmcl.2005.07.050 |
0.361 |
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| 2005 |
Kenski DM, Zhang C, von Zastrow M, Shokat KM. Chemical genetic engineering of G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 280: 35051-61. PMID 16081410 DOI: 10.1074/Jbc.M507594200 |
0.814 |
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| 2005 |
Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (New York, N.Y.). 308: 1318-21. PMID 15919995 DOI: 10.1126/Science1108367 |
0.621 |
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| 2005 |
Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, Cross JV, Templeton DJ, Shokat KM. A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nature Methods. 2: 435-41. PMID 15908922 DOI: 10.1038/Nmeth764 |
0.84 |
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| 2005 |
Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 46: 13-21. PMID 15820690 DOI: 10.1016/J.Neuron.2005.03.009 |
0.612 |
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| 2005 |
Kumar A, Mandiyan V, Suzuki Y, Zhang C, Rice J, Tsai J, Artis DR, Ibrahim P, Bremer R. Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma Journal of Molecular Biology. 348: 183-193. PMID 15808862 DOI: 10.1016/J.Jmb.2005.02.039 |
0.355 |
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| 2005 |
Tanaka M, Bateman R, Rauh D, Vaisberg E, Ramachandani S, Zhang C, Hansen KC, Burlingame AL, Trautman JK, Shokat KM, Adams CL. An unbiased cell morphology-based screen for new, biologically active small molecules. Plos Biology. 3: e128. PMID 15799708 DOI: 10.1371/Journal.Pbio.0030128 |
0.817 |
|
| 2005 |
Jones MH, Huneycutt BJ, Pearson CG, Zhang C, Morgan G, Shokat K, Bloom K, Winey M. Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Current Biology : Cb. 15: 160-5. PMID 15668173 DOI: 10.1016/J.Cub.2005.01.010 |
0.598 |
|
| 2004 |
Blethrow J, Zhang C, Shokat KM, Weiss EL. Design and use of analog-sensitive protein kinases. Current Protocols in Molecular Biology. Unit 18.11. PMID 18265343 DOI: 10.1002/0471142727.Mb1811S66 |
0.843 |
|
| 2004 |
Wan L, de los Santos T, Zhang C, Shokat K, Hollingsworth NM. Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Molecular Biology of the Cell. 15: 11-23. PMID 14595109 DOI: 10.1091/Mbc.E03-07-0499 |
0.678 |
|
| 2003 |
Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Research. 63: 8930-8. PMID 14695210 |
0.824 |
|
| 2003 |
Papa FR, Zhang C, Shokat K, Walter P. Bypassing a kinase activity with an ATP-competitive drug. Science (New York, N.Y.). 302: 1533-7. PMID 14564015 DOI: 10.1126/Science.1090031 |
0.648 |
|
| 2003 |
Sekiya-Kawasaki M, Groen AC, Cope MJ, Kaksonen M, Watson HA, Zhang C, Shokat KM, Wendland B, McDonald KL, McCaffery JM, Drubin DG. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. The Journal of Cell Biology. 162: 765-72. PMID 12952930 DOI: 10.1083/Jcb.200305077 |
0.539 |
|
| 2003 |
Denzel A, Hare KJ, Zhang C, Shokat K, Jenkinson EJ, Anderson G, Hayday A. Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development. Journal of Immunology (Baltimore, Md. : 1950). 171: 519-23. PMID 12847211 DOI: 10.4049/Jimmunol.171.2.519 |
0.67 |
|
| 2003 |
Benjamin KR, Zhang C, Shokat KM, Herskowitz I. Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes & Development. 17: 1524-39. PMID 12783856 DOI: 10.1101/Gad.1101503 |
0.62 |
|
| 2003 |
Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 100: 4287-92. PMID 12646704 DOI: 10.1073/Pnas.0636870100 |
0.793 |
|
| 2003 |
Abeliovich H, Zhang C, Dunn WA, Shokat KM, Klionsky DJ. Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Molecular Biology of the Cell. 14: 477-90. PMID 12589048 DOI: 10.1091/Mbc.E02-07-0413 |
0.613 |
|
| 2002 |
Weiss EL, Kurischko C, Zhang C, Shokat K, Drubin DG, Luca FC. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. The Journal of Cell Biology. 158: 885-900. PMID 12196508 DOI: 10.1083/Jcb.200203094 |
0.583 |
|
| 2002 |
Fan QW, Zhang C, Shokat KM, Weiss WA. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Current Biology : Cb. 12: 1386-94. PMID 12194819 DOI: 10.1016/S0960-9822(02)01070-9 |
0.687 |
|
| 2002 |
Niswender CM, Ishihara RW, Judge LM, Zhang C, Shokat KM, McKnight GS. Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. The Journal of Biological Chemistry. 277: 28916-22. PMID 12034735 DOI: 10.1074/Jbc.M203327200 |
0.675 |
|
| 2000 |
Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annual Review of Biophysics and Biomolecular Structure. 29: 577-606. PMID 10940260 DOI: 10.1146/Annurev.Biophys.29.1.577 |
0.743 |
|
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