Justine L. Lam, Ph.D.
Affiliations: | 2006 | University of California, San Francisco, San Francisco, CA |
Area:
PharmacologyGoogle:
"Justine Lam"Parents
Sign in to add mentor| Leslie Z. Benet | grad student | 2006 | UCSF | |
| (Defining the interplay between hepatic enzymes and transporters in vitro and in vivo.) | ||||
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Publications
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| Stypinski D, Fostvedt L, Lam JL, et al. (2020) Metabolism, Excretion, and Pharmacokinetics of Lorlatinib (PF-06463922) and Evaluation of the Impact of Radiolabel Position and Other Factors on Comparability of Data Across 2 ADME Studies. Journal of Clinical Pharmacology |
| Lam JL, Vaz A, Hee B, et al. (2016) Metabolism, excretion and pharmacokinetics of [(14)C]Glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-42 |
| Yanochko GM, Vitsky A, Heyen JR, et al. (2013) Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 451-64 |
| Varma MV, Lin J, Bi YA, et al. (2013) Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 966-74 |
| Lam JL, Okochi H, Huang Y, et al. (2006) In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1336-44 |
| Lam JL, Benet LZ. (2004) Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1311-6 |