Deborah Soto-Ortega, Ph.D.

Affiliations: 
2010 Biomedical Engineering University of South Carolina, Columbia, SC 
Area:
Biomedical Engineering
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"Deborah Soto-Ortega"

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Melissa A. Moss grad student 2010 University of South Carolina
 (Study of the structural and physical properties of small molecule and nanoparticle inhibitors of amyloid-beta protein fibril formation in Alzheimer's disease.)
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Publications

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Moore KA, Pate KM, Soto-Ortega DD, et al. (2017) Influence of gold nanoparticle surface chemistry and diameter upon Alzheimer's disease amyloid-β protein aggregation. Journal of Biological Engineering. 11: 5
Kayello H, Visco DP, Tseng JH, et al. (2013) A novel computer-aided molecular approach using the signature molecular descriptor to design potentially new non-intuitive amyloid-Î aggregation inhibitors Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 2-3
Soto-Ortega DD, Murphy BP, Gonzalez-Velasquez FJ, et al. (2011) Inhibition of amyloid-β aggregation by coumarin analogs can be manipulated by functionalization of the aromatic center. Bioorganic & Medicinal Chemistry. 19: 2596-602
Gonzalez-Velasquez F, Reed JW, Fuseler JW, et al. (2011) Activation of brain endothelium by soluble aggregates of the amyloid-β protein involves nuclear factor-κB. Current Alzheimer Research. 8: 81-94
Gonzalez-Velasquez FJ, Reed JW, Fuseler JW, et al. (2010) Soluble amyloid-β protein aggregates induce nuclear factor-κB mediated upregulation of adhesion molecule expression to stimulate brain endothelium for monocyte adhesion Journal of Adhesion Science and Technology. 24: 2105-2126
Davis TJ, Soto-Ortega DD, Kotarek JA, et al. (2009) Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight. Molecular Pharmacology. 76: 405-13
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