Douglas B. Stairs, Ph.D.

Affiliations: 
2004 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology, Genetics
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"Douglas Stairs"

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Lewis A. Chodosh grad student 2004 Penn
 (Discovery, characterization and functional analysis of the serine /threonine kinase Krct.)
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Publications

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Lehman HL, Yang X, Welsh PA, et al. (2015) p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma. The American Journal of Pathology. 185: 240-51
Vega ME, Giroux V, Natsuizaka M, et al. (2014) Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle (Georgetown, Tex.). 13: 3857-66
Chen CC, Stairs DB, Boxer RB, et al. (2012) Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development. 26: 2154-68
Bhardwaj A, McGarrity TJ, Stairs DB, et al. (2012) Barrett's Esophagus: Emerging Knowledge and Management Strategies. Pathology Research International. 2012: 814146
Kong J, Crissey MA, Stairs DB, et al. (2011) Cox2 and β-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditions. Neoplasia (New York, N.Y.). 13: 792-805
Stairs DB, Bayne LJ, Rhoades B, et al. (2011) Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell. 19: 470-83
Stairs DB, Kong J, Lynch JP. (2010) Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia. Progress in Molecular Biology and Translational Science. 96: 231-70
Chen CC, Boxer RB, Stairs DB, et al. (2010) Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Research : Bcr. 12: R72
Ohashi S, Natsuizaka M, Wong GS, et al. (2010) Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Research. 70: 4174-84
Kong J, Stairs DB, Lynch JP. (2010) Modelling Barrett's oesophagus. Biochemical Society Transactions. 38: 321-6
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