Donald M. Simons, Ph.D.

Affiliations: 
2007 Drexel University, Philadelphia, PA, United States 
Area:
Cell Biology, Biomedical Engineering, Immunology
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"Donald Simons"

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Peter I. Lelkes grad student 2007 Drexel
 (A dissection of T cell receptor signaling pathways in primary human T cells activated in the rotating -wall vessel bioreactor.)
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Publications

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Oh S, Aitken M, Simons DM, et al. (2012) Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis. Journal of Immunology (Baltimore, Md. : 1950). 188: 4171-80
Cozzo Picca C, Simons DM, Oh S, et al. (2011) CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion. Proceedings of the National Academy of Sciences of the United States of America. 108: 14890-5
Simons DM, Caton AJ. (2011) Flow cytometric profiling of mature and developing regulatory T cells in the thymus. Methods in Molecular Biology (Clifton, N.J.). 707: 55-69
Simons DM, Gardner EM, Lelkes PI. (2010) Intact T cell receptor signaling by CD4(+) T cells cultured in the rotating wall-vessel bioreactor. Journal of Cellular Biochemistry. 109: 1201-9
Simons DM, Gardner EM, Lelkes PI. (2009) Sub-mitogenic phorbol myristate acetate co-stimulation rescues the PHA-induced activation of both naïve and memory T cells cultured in the rotating-wall vessel bioreactor. Cell Biology International. 33: 882-6
Roszell B, Mondrinos MJ, Seaton A, et al. (2009) Efficient derivation of alveolar type II cells from embryonic stem cells for in vivo application. Tissue Engineering. Part A. 15: 3351-65
Simons DM, Gardner EM, Lelkes PI. (2006) Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time-dependent manner. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1287-92
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