| Year |
Citation |
Score |
| 2023 |
Parsons M, Parsons B, Dean M, DeRocher AE, Islam Z, Maly DJ, Jensen BC. An essential protein kinase: a functional analysis of regulation and the identification of inhibitors. Frontiers in Parasitology. 2. PMID 38099268 DOI: 10.3389/fpara.2023.1272378 |
0.475 |
|
| 2023 |
Chakraborty S, Ahler E, Simon JJ, Fang L, Potter ZE, Sitko KA, Stephany JJ, Guttman M, Fowler DM, Maly DJ. Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics. Cell Chemical Biology. PMID 37683649 DOI: 10.1016/j.chembiol.2023.08.005 |
0.668 |
|
| 2023 |
Nguyen V, Ahler E, Sitko KA, Stephany JJ, Maly DJ, Fowler DM. Molecular determinants of Hsp90 dependence of Src kinase revealed by deep mutational scanning. Protein Science : a Publication of the Protein Society. e4656. PMID 37167432 DOI: 10.1002/pro.4656 |
0.386 |
|
| 2023 |
Golkowski M, Lius A, Sapre T, Lau HT, Moreno T, Maly DJ, Ong SE. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Molecular Cell. PMID 36736316 DOI: 10.1016/j.molcel.2023.01.015 |
0.413 |
|
| 2023 |
Tambo CS, Tripathi S, Perera BGK, Maly DJ, Bridges AJ, Kiss G, Rubin SM. Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics. Acs Chemical Biology. PMID 36724382 DOI: 10.1021/acschembio.3c00015 |
0.458 |
|
| 2021 |
Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nature Chemical Biology. PMID 34556859 DOI: 10.1038/s41589-021-00852-0 |
0.419 |
|
| 2021 |
Hulverson MA, Choi R, Vidadala RSR, Whitman GR, Vidadala VN, Ojo KK, Barrett LK, Lynch JJ, Marsh K, Kempf DJ, Maly DJ, Van Voorhis WC. Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis. Acs Infectious Diseases. PMID 33565854 DOI: 10.1021/acsinfecdis.0c00803 |
0.487 |
|
| 2020 |
Fang L, Maly DJ. The Right Tool for the Job: A Chemical and Genetic Toolkit for Interrogating DCLK1 Function. Cell Chemical Biology. 27: 1221-1223. PMID 33065025 DOI: 10.1016/j.chembiol.2020.09.007 |
0.668 |
|
| 2020 |
Golkowski M, Lau HT, Chan M, Kenerson H, Vidadala VN, Shoemaker A, Maly DJ, Yeung RS, Gujral TS, Ong SE. Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma. Cell Systems. PMID 32755597 DOI: 10.1016/J.Cels.2020.07.006 |
0.334 |
|
| 2020 |
Potter ZE, Lau HT, Chakraborty S, Fang L, Guttman M, Ong SE, Fowler DM, Maly DJ. Parallel Chemoselective Profiling for Mapping Protein Structure. Cell Chemical Biology. PMID 32649906 DOI: 10.1016/J.Chembiol.2020.06.014 |
0.656 |
|
| 2020 |
Rose JC, Popp NA, Richardson CD, Stephany JJ, Mathieu J, Wei CT, Corn JE, Maly DJ, Fowler DM. Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs. Nature Communications. 11: 2697. PMID 32483117 DOI: 10.1038/S41467-020-16542-9 |
0.302 |
|
| 2020 |
Fang L, Vilas-Boas J, Chakraborty S, Potter ZE, Register AC, Seeliger MA, Maly DJ. How ATP-competitive inhibitors allosterically modulate tyrosine kinases that contain a Src-like regulatory architecture. Acs Chemical Biology. PMID 32479050 DOI: 10.1021/Acschembio.0C00429 |
0.774 |
|
| 2020 |
Choi R, Hulverson MA, Huang W, Vidadala RSR, Whitman GR, Barrett LK, Schaefer DA, Betzer DP, Riggs MW, Stone Doggett J, Hemphill A, Miguel Ortega-Mora L, McCloskey MC, Arnold SLM, Hackman RC, ... ... Maly DJ, et al. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. International Journal For Parasitology. PMID 32224121 DOI: 10.1016/J.Ijpara.2020.01.006 |
0.506 |
|
| 2020 |
Golkowski M, Vidadala VN, Lau HT, Shoemaker A, Shimizu-Albergine M, Beavo J, Maly DJ, Ong SE. Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks. Journal of Proteome Research. PMID 32037842 DOI: 10.1021/Acs.Jproteome.9B00742 |
0.541 |
|
| 2020 |
Bucko PJ, Lombard CK, Rathbun L, Bhat A, Garcia I, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD. Subcellular Drug Targeting Illuminates Local Action of Polo‐like kinase 1 and Aurora A During Mitosis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01916 |
0.446 |
|
| 2019 |
Bucko PJ, Lombard CK, Rathbun L, Garcia I, Bhat A, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD. Subcellular drug targeting illuminates local kinase action. Elife. 8. PMID 31872801 DOI: 10.7554/Elife.52220 |
0.592 |
|
| 2019 |
Feldman HC, Vidadala VN, Potter ZE, Papa FR, Backes BJ, Maly DJ. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1. Acs Chemical Biology. PMID 31609569 DOI: 10.1021/Acschembio.9B00482 |
0.573 |
|
| 2019 |
Foight GW, Wang Z, Wei CT, Jr Greisen P, Warner KM, Cunningham-Bryant D, Park K, Brunette TJ, Sheffler W, Baker D, Maly DJ. Multi-input chemical control of protein dimerization for programming graded cellular responses. Nature Biotechnology. PMID 31501561 DOI: 10.1038/S41587-019-0242-8 |
0.325 |
|
| 2019 |
Fang L, Chakraborty S, Dieter EM, Potter ZE, Lombard CK, Maly DJ. Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes. Journal of the American Chemical Society. PMID 31274292 DOI: 10.1021/Jacs.9B02963 |
0.779 |
|
| 2019 |
Arnold SLM, Choi R, Hulverson MA, Whitman GR, McCloskey MC, Dorr CS, Vidadala RSR, Khatod M, Morada M, Barrett LK, Maly DJ, Yarlett N, Van Voorhis WC. P-glycoprotein mediated efflux reduces the in vivo efficacy of a therapeutic targeting the gastrointestinal parasite Cryptosporidium. The Journal of Infectious Diseases. PMID 31180118 DOI: 10.1093/Infdis/Jiz269 |
0.351 |
|
| 2019 |
Chakraborty S, Inukai T, Fang L, Golkowski M, Maly DJ. Targeting dynamic ATP-binding site features allows discrimination between highly homologous protein kinases. Acs Chemical Biology. PMID 31038916 DOI: 10.1021/Acschembio.9B00214 |
0.751 |
|
| 2019 |
Shrestha A, Ojo KK, Koston F, Ruttkowski B, Vidadala RSR, Dorr CS, Navaluna ED, Whitman GR, Barrett KF, Barrett LK, Hulverson MA, Choi R, Michaels SA, Maly DJ, Hemphill A, et al. Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro. International Journal For Parasitology. Drugs and Drug Resistance. 10: 9-19. PMID 30959327 DOI: 10.1016/J.Ijpddr.2019.03.004 |
0.401 |
|
| 2019 |
Ahler E, Register AC, Chakraborty S, Fang L, Dieter EM, Sitko KA, Vidadala RSR, Trevillian BM, Golkowski M, Gelman H, Stephany JJ, Rubin AF, Merritt EA, Fowler DM, Maly DJ. A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Molecular Cell. PMID 30956043 DOI: 10.1016/J.Molcel.2019.02.003 |
0.741 |
|
| 2019 |
Cunningham-Bryant D, Dieter EM, Foight GW, Rose JC, Loutey DE, Maly DJ. A Chemically-Disrupted Proximity System for Controlling Dynamic Cellular Processes. Journal of the American Chemical Society. PMID 30735038 DOI: 10.1021/Jacs.8B12382 |
0.373 |
|
| 2019 |
Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung. Plos One. 14: e0209824. PMID 30625178 DOI: 10.1371/Journal.Pone.0209824 |
0.385 |
|
| 2019 |
Bucko PJ, Lombard CK, Rathbun L, Garcia I, Bhat A, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD. Author response: Subcellular drug targeting illuminates local kinase action Elife. DOI: 10.7554/Elife.52220.Sa2 |
0.422 |
|
| 2018 |
Hulverson MA, Bruzual I, McConnell EV, Huang W, Vidadala RSR, Choi R, Arnold SLM, Whitman GR, McCloskey MC, Barrett LK, Rivas KL, Scheele S, DeRocher AE, Parsons M, Ojo KK, ... Maly DJ, et al. Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine and 5-Aminopyrazole-4-Carboximide Bumped Kinase Inhibitors against Toxoplasmosis. The Journal of Infectious Diseases. PMID 30423128 DOI: 10.1093/Infdis/Jiy664 |
0.47 |
|
| 2018 |
Lombard CK, Davis AL, Inukai T, Maly DJ. Allosteric modulation of JNK docking-site interactions with ATP-competitive inhibitors. Biochemistry. PMID 30211540 DOI: 10.1021/Acs.Biochem.8B00776 |
0.547 |
|
| 2018 |
Golkowski M, Perera GK, Vidadala VN, Ojo KK, Van Voorhis WC, Maly DJ, Ong SE. Kinome chemoproteomics characterization of pyrrolo[3,4-c]pyrazoles as potent and selective inhibitors of glycogen synthase kinase 3. Molecular Omics. 14: 26-36. PMID 29725679 DOI: 10.1039/c7mo00006e |
0.501 |
|
| 2018 |
Scheele S, Geiger JA, DeRocher AE, Choi R, Smith TR, Hulverson MA, Vidadala RSR, Barrett LK, Maly DJ, Merritt EA, Ojo KK, Van Voorhis WC, Parsons M.
calcium-dependent protein kinase 1 inhibitors: probing activity and resistance using cellular thermal shift assays. Antimicrobial Agents and Chemotherapy. PMID 29555627 DOI: 10.1128/Aac.00051-18 |
0.503 |
|
| 2018 |
Vidadala RSR, Golkowski M, Hulverson MA, Choi R, McCloskey MC, Whitman GR, Huang W, Arnold SLM, Barrett LK, Fan E, Merritt EA, Van Voorhis WC, Ojo KK, Maly DJ. 7H-pyrrolo[2,3-d]pyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo[3,4-d]pyrimidin-4-amine based inhibitors. Acs Infectious Diseases. PMID 29522315 DOI: 10.1021/Acsinfecdis.7B00224 |
0.478 |
|
| 2018 |
Gimenez F, Hines SA, Evanoff R, Ojo KK, Van Voorhis WC, Maly DJ, Vidadala RSR, Mealey RH. In vitro growth inhibition of Theileria equi by bumped kinase inhibitors. Veterinary Parasitology. 251: 90-94. PMID 29426483 DOI: 10.1016/J.Vetpar.2017.12.024 |
0.418 |
|
| 2018 |
Uo T, Sun S, Haugk K, Epilepsia KS, Damodarasamy M, Hulverson M, VanVoorhis W, Ojo KK, Vidadala R, Maly D, Plymate S, Sprenger CC. Abstract 3837: Bumped kinase inhibitor 1553 selectively inhibits androgen receptor positive prostate cancer Cancer Research. 78: 3837-3837. DOI: 10.1158/1538-7445.Am2018-3837 |
0.41 |
|
| 2017 |
Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G. In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites. International Journal For Parasitology. PMID 28899692 DOI: 10.1016/J.Ijpara.2017.08.005 |
0.467 |
|
| 2017 |
Hulverson MA, Choi R, L M Arnold S, Schaefer DA, Hemphill A, McCloskey MC, Betzer DP, Müller J, S R Vidadala R, Whitman GR, Rivas KL, Barrett LK, Hackman RC, Love MS, McNamara CW, ... ... Maly DJ, et al. Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International Journal For Parasitology. PMID 28899690 DOI: 10.1016/J.Ijpara.2017.08.006 |
0.345 |
|
| 2017 |
Rose JC, Stephany JJ, Wei CT, Fowler DM, Maly DJ. Rheostatic control of Cas9-mediated DNA double strand break (DSB) generation and genome editing. Acs Chemical Biology. PMID 28895730 DOI: 10.1021/Acschembio.7B00652 |
0.312 |
|
| 2017 |
Rose JC, Stephany JJ, Valente WJ, Trevillian BM, Dang HV, Bielas JH, Maly DJ, Fowler DM. Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics. Nature Methods. PMID 28737741 DOI: 10.1038/Nmeth.4368 |
0.354 |
|
| 2017 |
Golkowski M, Maly DJ, Ong SE. Proteomic Profiling of Protein Kinase Inhibitor Targets by Mass Spectrometry. Methods in Molecular Biology (Clifton, N.J.). 1636: 105-117. PMID 28730476 DOI: 10.1007/978-1-4939-7154-1_8 |
0.531 |
|
| 2017 |
Register AC, Chakraborty S, Maly DJ. Allosteric Modulation of Src Family Kinases with ATP-Competitive Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 1636: 79-89. PMID 28730474 DOI: 10.1007/978-1-4939-7154-1_6 |
0.543 |
|
| 2017 |
Arnold SLM, Choi R, Hulverson MA, Schaefer DA, Vinayak S, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Fan E, Maly DJ, Riggs MW, Striepen B, et al. Bumped kinase inhibitor gastrointestinal exposure is necessary to treat Cryptosporidium infection. The Journal of Infectious Diseases. PMID 28541457 DOI: 10.1093/Infdis/Jix247 |
0.347 |
|
| 2017 |
Huang W, Choi R, Hulverson MA, Zhang Z, McCloskey MC, Schaefer DA, Whitman GR, Barrett LK, Vidadala RSR, Riggs MW, Maly DJ, Van Voorhis WC, Ojo KK, Fan E. 5-Aminopyrazole-4-carboxamide based compounds prevent the growth of Cryptosporidium parvum. Antimicrobial Agents and Chemotherapy. PMID 28533246 DOI: 10.1128/Aac.00020-17 |
0.392 |
|
| 2017 |
Müller J, Aguado-Martínez A, Ortega-Mora LM, Moreno-Gonzalo J, Ferre I, Hulverson MA, Choi R, McCloskey MC, Barrett LK, Maly DJ, Ojo KK, Van Voorhis W, Hemphill A. Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. The Journal of Antimicrobial Chemotherapy. PMID 28486633 DOI: 10.1093/Jac/Dkx134 |
0.363 |
|
| 2017 |
Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metabolism. 25: 1207. PMID 28467938 DOI: 10.1016/J.Cmet.2017.04.026 |
0.323 |
|
| 2017 |
Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metabolism. 25: 883-897.e8. PMID 28380378 DOI: 10.1016/J.Cmet.2017.03.018 |
0.428 |
|
| 2017 |
Müller J, Aguado-Martínez A, Balmer V, Maly DJ, Fan E, Ortega-Mora LM, Ojo KK, Van Voorhis WC, Hemphill A. Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial Agents and Chemotherapy. PMID 28137808 DOI: 10.1128/Aac.02324-16 |
0.323 |
|
| 2017 |
Golkowski M, Vidadala RS, Lombard CK, Suh HW, Maly DJ, Ong SE. Kinobead and single-shot LC-MS profiling identifies selective PKD inhibitors. Journal of Proteome Research. PMID 28102076 DOI: 10.1021/Acs.Jproteome.6B00817 |
0.627 |
|
| 2017 |
Van Voorhis WC, Doggett JS, Parsons M, Hulverson MA, Choi R, Arnold S, Riggs MW, Hemphill A, Howe DK, Mealey RH, Lau AO, Merritt EA, Maly DJ, Fan E, Ojo KK. Extended-spectrum antiprotozoal bumped kinase inhibitors: A review. Experimental Parasitology. PMID 28065755 DOI: 10.1016/J.Exppara.2017.01.001 |
0.572 |
|
| 2017 |
Feldman HC, Maly DJ. Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α. Methods in Molecular Biology (Clifton, N.J.). 1513: 233-242. PMID 27807842 DOI: 10.1007/978-1-4939-6539-7_17 |
0.562 |
|
| 2017 |
Ahler E, Chakraborty S, Fan L, Maly DJ, Fowler DM. Abstract 5886: High-throughput mutagenesis reveals novel mechanisms of drug resistance in the proto-oncogene Src kinase Cancer Research. 77: 5886-5886. DOI: 10.1158/1538-7445.Am2017-5886 |
0.44 |
|
| 2016 |
Schaefer DA, Betzer DP, Smith KD, Millman ZG, Michalski HC, Menchaca SE, Zambriski JA, Ojo KK, Hulverson MA, Arnold SL, Rivas KL, Vidadala RS, Huang W, Barrett LK, Maly DJ, et al. Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis. The Journal of Infectious Diseases. 214: 1856-1864. PMID 27923949 DOI: 10.1093/Infdis/Jiw488 |
0.427 |
|
| 2016 |
Bansal A, Ojo KK, Mu J, Maly DJ, Van Voorhis WC, Miller LH. Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G. Mbio. 7. PMID 27923926 DOI: 10.1128/Mbio.02011-16 |
0.575 |
|
| 2016 |
Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nature Chemical Biology. PMID 27870838 DOI: 10.1038/Nchembio.2244 |
0.722 |
|
| 2016 |
Huang W, Hulverson MA, Zhang Z, Choi R, Hart KJ, Kennedy M, Vidadala RS, Maly DJ, Van Voorhis WC, Lindner SE, Fan E, Ojo KK. 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorganic & Medicinal Chemistry Letters. PMID 27780638 DOI: 10.1016/J.Bmcl.2016.10.014 |
0.425 |
|
| 2016 |
Ojo KK, Dangoudoubiyam S, Verma SK, Scheele S, DeRocher AE, Yeargan M, Choi R, Smith TR, Rivas KL, Hulverson MA, Barrett LK, Fan E, Maly DJ, Parsons M, Dubey JP, et al. Selective inhibition of Sarcocystis neurona calcium-cependent protein kinase 1 for equine protozoal myeloencephalitis therapy. International Journal For Parasitology. PMID 27729271 DOI: 10.1016/J.Ijpara.2016.08.003 |
0.413 |
|
| 2016 |
Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, ... ... Maly DJ, et al. Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. Journal of Medicinal Chemistry. 59: 6531-46. PMID 27309760 DOI: 10.1021/Acs.Jmedchem.6B00760 |
0.434 |
|
| 2016 |
Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands. Acs Chemical Biology. PMID 27227314 DOI: 10.1021/Acschembio.5B00940 |
0.84 |
|
| 2016 |
Jensen BC, Booster N, Vidadala RS, Maly DJ, Parsons M. A novel protein kinase is essential in bloodstream Trypanosoma brucei. International Journal For Parasitology. 46: 479-83. PMID 27018127 DOI: 10.1016/J.Ijpara.2016.03.001 |
0.453 |
|
| 2016 |
Crowther GJ, Hillesland HK, Keyloun KR, Reid MC, Lafuente-Monasterio MJ, Ghidelli-Disse S, Leonard SE, He P, Jones JC, Krahn MM, Mo JS, Dasari KS, Fox AM, Boesche M, El Bakkouri M, ... ... Maly DJ, et al. Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds. Plos One. 11: e0149996. PMID 26934697 DOI: 10.1371/Journal.Pone.0149996 |
0.528 |
|
| 2016 |
Pedroni MJ, Vidadala RS, Choi R, Keyloun KR, Reid MC, Murphy RC, Barrett LK, Van Voorhis WC, Maly DJ, Ojo KK, Lau AO. Bumped kinase inhibitor prohibits egression in Babesia bovis. Veterinary Parasitology. 215: 22-8. PMID 26790733 DOI: 10.1016/J.Vetpar.2015.10.023 |
0.512 |
|
| 2016 |
Gower CM, Thomas JR, Harrington E, Murphy J, Chang ME, Cornella-Taracido I, Jain RK, Schirle M, Maly DJ. Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity. Acs Chemical Biology. 11: 121-31. PMID 26505072 DOI: 10.1021/Acschembio.5B00847 |
0.747 |
|
| 2016 |
Sprenger CC, Plymate S, Maly D, Voorhis WV, Ojo KK. Abstract 3033: Bumped kinase inhibitors: A novel therapy for castration-resistant prostate cancer Cancer Research. 76: 3033-3033. DOI: 10.1158/1538-7445.Am2016-3033 |
0.401 |
|
| 2016 |
Qi JY, Moore PC, Thamsen M, Ghosh R, Gliedt MJ, Maly DJ, Backes BJ, Papa FR, Oakes SA. Abstract 2862: The balance of divergent IRE1α signaling regulates pancreatic neuroendocrine tumor growth Cancer Research. 76: 2862-2862. DOI: 10.1158/1538-7445.Am2016-2862 |
0.338 |
|
| 2015 |
Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, ... ... Maly DJ, et al. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. Acs Medicinal Chemistry Letters. 6: 1184-1189. PMID 26693272 DOI: 10.1021/Acsmedchemlett.5B00319 |
0.341 |
|
| 2015 |
Winzer P, Müller J, Aguado-Martínez A, Rahman M, Balmer V, Manser V, Ortega-Mora LM, Ojo KK, Fan E, Maly DJ, Van Voorhis WC, Hemphill A. In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial Agents and Chemotherapy. 59: 6361-74. PMID 26248379 DOI: 10.1128/Aac.01236-15 |
0.337 |
|
| 2015 |
Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Molecular Cancer Therapeutics. 14: 419-28. PMID 25522764 DOI: 10.1158/1535-7163.Mct-14-0526 |
0.555 |
|
| 2014 |
Maly DJ, Papa FR. Druggable sensors of the unfolded protein response. Nature Chemical Biology. 10: 892-901. PMID 25325700 DOI: 10.1038/Nchembio.1664 |
0.319 |
|
| 2014 |
Register AC, Leonard SE, Maly DJ. SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family. Biochemistry. 53: 6910-23. PMID 25302671 DOI: 10.1021/Bi5008194 |
0.425 |
|
| 2014 |
Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, ... ... Maly DJ, et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 158: 534-48. PMID 25018104 DOI: 10.1016/J.Cell.2014.07.002 |
0.775 |
|
| 2014 |
Leonard SE, Register AC, Krishnamurty R, Brighty GJ, Maly DJ. Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors. Acs Chemical Biology. 9: 1894-905. PMID 24946274 DOI: 10.1021/Cb500371G |
0.863 |
|
| 2014 |
Keyloun KR, Reid MC, Choi R, Song Y, Fox AM, Hillesland HK, Zhang Z, Vidadala R, Merritt EA, Lau AO, Maly DJ, Fan E, Barrett LK, VAN Voorhis WC, Ojo KK. The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites. Parasitology. 141: 1499-509. PMID 24927073 DOI: 10.1017/S0031182014000857 |
0.571 |
|
| 2014 |
Hari SB, Merritt EA, Maly DJ. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chemistry & Biology. 21: 628-35. PMID 24704509 DOI: 10.1016/J.Chembiol.2014.02.016 |
0.857 |
|
| 2014 |
Doggett JS, Ojo KK, Fan E, Maly DJ, Van Voorhis WC. Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection. Antimicrobial Agents and Chemotherapy. 58: 3547-9. PMID 24687502 DOI: 10.1128/Aac.01823-13 |
0.489 |
|
| 2014 |
Ojo KK, Reid MC, Kallur Siddaramaiah L, Müller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A. Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. Plos One. 9: e92929. PMID 24681759 DOI: 10.1371/Journal.Pone.0092929 |
0.429 |
|
| 2014 |
Golkowski M, Brigham JL, Perera GK, Romano GE, Maly DJ, Ong SE. Rapid profiling of protein kinase inhibitors by quantitative proteomics. Medchemcomm. 5: 363-369. PMID 24648882 DOI: 10.1039/C3Md00315A |
0.591 |
|
| 2014 |
Gower CM, Chang ME, Maly DJ. Bivalent inhibitors of protein kinases. Critical Reviews in Biochemistry and Molecular Biology. 49: 102-15. PMID 24564382 DOI: 10.3109/10409238.2013.875513 |
0.635 |
|
| 2014 |
Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, ... ... Maly DJ, et al. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. European Journal of Medicinal Chemistry. 74: 562-73. PMID 24531197 DOI: 10.1016/J.Ejmech.2013.12.048 |
0.467 |
|
| 2014 |
Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, ... ... Maly DJ, et al. Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44. PMID 24494061 DOI: 10.1021/Ml400315S |
0.545 |
|
| 2014 |
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, ... ... Maly DJ, et al. A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. The Journal of Infectious Diseases. 209: 275-84. PMID 24123773 DOI: 10.1093/Infdis/Jit522 |
0.331 |
|
| 2013 |
Hari SB, Perera BG, Ranjitkar P, Seeliger MA, Maly DJ. Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src. Acs Chemical Biology. 8: 2734-43. PMID 24106839 DOI: 10.1021/Cb400663K |
0.848 |
|
| 2013 |
Castellanos-Gonzalez A, White AC, Ojo KK, Vidadala RS, Zhang Z, Reid MC, Fox AM, Keyloun KR, Rivas K, Irani A, Dann SM, Fan E, Maly DJ, Van Voorhis WC. A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis. The Journal of Infectious Diseases. 208: 1342-8. PMID 23878324 DOI: 10.1093/Infdis/Jit327 |
0.415 |
|
| 2013 |
Hari SB, Merritt EA, Maly DJ. Sequence determinants of a specific inactive protein kinase conformation. Chemistry & Biology. 20: 806-15. PMID 23790491 DOI: 10.1016/J.Chembiol.2013.05.005 |
0.85 |
|
| 2013 |
Andrews SS, Hill ZB, Perera BG, Maly DJ. Label transfer reagents to probe p38 MAPK binding partners. Chembiochem : a European Journal of Chemical Biology. 14: 209-16. PMID 23319368 DOI: 10.1002/Cbic.201200673 |
0.801 |
|
| 2013 |
Brigham JL, Perera BG, Maly DJ. A hexylchloride-based catch-and-release system for chemical proteomic applications. Acs Chemical Biology. 8: 691-9. PMID 23305300 DOI: 10.1021/Cb300623A |
0.811 |
|
| 2013 |
Krishnamurty R, Brigham JL, Leonard SE, Ranjitkar P, Larson ET, Dale EJ, Merritt EA, Maly DJ. Active site profiling reveals coupling between domains in SRC-family kinases. Nature Chemical Biology. 9: 43-50. PMID 23143416 DOI: 10.1038/Nchembio.1118 |
0.863 |
|
| 2013 |
Ranjitkar P, Perera BGK, Swaney DL, Hari SB, Larson ET, Krishnamurty R, Merritt EA, Villén J, Maly DJ. Correction to “Affinity-Based Probes Based on Type II Kinase Inhibitors” Journal of the American Chemical Society. 135: 948-948. DOI: 10.1021/Ja3120967 |
0.787 |
|
| 2012 |
Ranjitkar P, Perera BG, Swaney DL, Swaney DL, Hari SB, Larson ET, Krishnamurty R, Merritt EA, Villén J, Maly DJ. Affinity-based probes based on type II kinase inhibitors. Journal of the American Chemical Society. 134: 19017-25. PMID 23088519 DOI: 10.1021/Ja306035V |
0.832 |
|
| 2012 |
Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nature Chemical Biology. 8: 982-9. PMID 23086298 DOI: 10.1038/Nchembio.1094 |
0.834 |
|
| 2012 |
Hari SB, Ranjitkar P, Maly DJ. Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases. Methods in Molecular Biology (Clifton, N.J.). 928: 153-9. PMID 22956140 DOI: 10.1007/978-1-62703-008-3_12 |
0.843 |
|
| 2012 |
Ranjitkar P, Maly DJ. Affinity purification of protein kinases that adopt a specific inactive conformation. Methods in Molecular Biology (Clifton, N.J.). 928: 143-51. PMID 22956139 DOI: 10.1007/978-1-62703-008-3_11 |
0.814 |
|
| 2012 |
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorganic & Medicinal Chemistry Letters. 22: 5264-7. PMID 22795629 DOI: 10.1016/J.Bmcl.2012.06.050 |
0.564 |
|
| 2012 |
Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, ... ... Maly DJ, et al. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. The Journal of Clinical Investigation. 122: 2301-5. PMID 22565309 DOI: 10.1172/Jci61822 |
0.473 |
|
| 2012 |
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, ... ... Maly DJ, et al. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. Journal of Medicinal Chemistry. 55: 2803-10. PMID 22369268 DOI: 10.1021/Jm201725V |
0.849 |
|
| 2012 |
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, ... ... Maly DJ, et al. Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. Journal of Medicinal Chemistry. 55: 2416-26. PMID 22320388 DOI: 10.1021/Jm201713H |
0.829 |
|
| 2012 |
Hill ZB, Perera BG, Andrews SS, Maly DJ. Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors. Acs Chemical Biology. 7: 487-95. PMID 22148755 DOI: 10.1021/Cb200387G |
0.859 |
|
| 2011 |
Goreshnik I, Brock AM, Maly DJ. Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL. Bioorganic & Medicinal Chemistry Letters. 21: 4951-5. PMID 21807512 DOI: 10.1016/J.Bmcl.2011.06.134 |
0.776 |
|
| 2011 |
Krishnamurty R, Brock AM, Maly DJ. Protein kinase affinity reagents based on a 5-aminoindazole scaffold. Bioorganic & Medicinal Chemistry Letters. 21: 550-4. PMID 21078554 DOI: 10.1016/J.Bmcl.2010.10.069 |
0.861 |
|
| 2011 |
Hill ZB, Perera BG, Maly DJ. Bivalent inhibitors of the tyrosine kinases ABL and SRC: determinants of potency and selectivity. Molecular Biosystems. 7: 447-56. PMID 21060940 DOI: 10.1039/C0Mb00108B |
0.857 |
|
| 2010 |
Gregersen KA, Hill ZB, Gadd JC, Fujimoto BS, Maly DJ, Chiu DT. Intracellular delivery of bioactive molecules using light-addressable nanocapsules. Acs Nano. 4: 7603-11. PMID 21117640 DOI: 10.1021/Nn102345F |
0.744 |
|
| 2010 |
Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera BG, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CL, White AC, Merritt EA, Van Voorhis WC, Maly DJ. Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. Acs Medicinal Chemistry Letters. 1: 331-335. PMID 21116453 DOI: 10.1021/Ml100096T |
0.822 |
|
| 2010 |
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, et al. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nature Structural & Molecular Biology. 17: 602-7. PMID 20436472 DOI: 10.1038/Nsmb.1818 |
0.603 |
|
| 2010 |
Ranjitkar P, Brock AM, Maly DJ. Affinity reagents that target a specific inactive form of protein kinases. Chemistry & Biology. 17: 195-206. PMID 20189109 DOI: 10.1016/J.Chembiol.2010.01.008 |
0.83 |
|
| 2010 |
Krishnamurty R, Maly DJ. Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors. Acs Chemical Biology. 5: 121-38. PMID 20044834 DOI: 10.1021/Cb9002656 |
0.847 |
|
| 2010 |
Goreshnik I, Maly DJ. A small molecule-regulated guanine nucleotide exchange factor. Journal of the American Chemical Society. 132: 938-40. PMID 20020680 DOI: 10.1021/Ja907886V |
0.777 |
|
| 2009 |
Hill ZB, Perera BG, Maly DJ. A chemical genetic method for generating bivalent inhibitors of protein kinases. Journal of the American Chemical Society. 131: 6686-8. PMID 19391594 DOI: 10.1021/Ja900871Y |
0.86 |
|
| 2009 |
Seeliger MA, Ranjitkar P, Kasap C, Shan Y, Shaw DE, Shah NP, Kuriyan J, Maly DJ. Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Research. 69: 2384-2392. PMID 19276351 DOI: 10.1158/0008-5472.Can-08-3953 |
0.774 |
|
| 2009 |
Blacken GR, Volný M, Diener M, Jackson KE, Ranjitkar P, Maly DJ, Turecek F. Reactive landing of gas-phase ions as a tool for the fabrication of metal oxide surfaces for in situ phosphopeptide enrichment. Journal of the American Society For Mass Spectrometry. 20: 915-26. PMID 19251440 DOI: 10.1016/J.Jasms.2009.01.006 |
0.641 |
|
| 2008 |
Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM. Tuning a three-component reaction for trapping kinase substrate complexes. Journal of the American Chemical Society. 130: 17568-74. PMID 19053485 DOI: 10.1021/Ja807066F |
0.693 |
|
| 2008 |
Perera BG, Maly DJ. Design, synthesis and characterization of "clickable" 4-anilinoquinazoline kinase inhibitors. Molecular Biosystems. 4: 542-50. PMID 18493651 DOI: 10.1039/B720014E |
0.859 |
|
| 2007 |
Krishnamurty R, Maly DJ. Chemical genomic and proteomic methods for determining kinase inhibitor selectivity. Combinatorial Chemistry & High Throughput Screening. 10: 652-66. PMID 18045078 DOI: 10.2174/138620707782507368 |
0.87 |
|
| 2007 |
Maly DJ. Exploring the intermembrane space. Acs Chemical Biology. 2: 213-6. PMID 17455895 DOI: 10.1021/Cb7000796 |
0.323 |
|
| 2005 |
Gosalia DN, Salisbury CM, Maly DJ, Ellman JA, Diamond SL. Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics. 5: 1292-8. PMID 15742319 DOI: 10.1002/Pmic.200401011 |
0.781 |
|
| 2004 |
Maly DJ, Allen JA, Shokat KM. A mechanism-based cross-linker for the identification of kinase-substrate pairs. Journal of the American Chemical Society. 126: 9160-1. PMID 15281787 DOI: 10.1021/Ja048659I |
0.654 |
|
| 2002 |
Maly DJ, Huang L, Ellman JA. Combinatorial strategies for targeting protein families: application to the proteases. Chembiochem : a European Journal of Chemical Biology. 3: 16-37. PMID 17590950 DOI: 10.1002/1439-7633(20020104)3:1<16::Aid-Cbic16>3.0.Co;2-Z |
0.696 |
|
| 2002 |
Salisbury CM, Maly DJ, Ellman JA. Peptide microarrays for the determination of protease substrate specificity. Journal of the American Chemical Society. 124: 14868-70. PMID 12475327 DOI: 10.1021/Ja027477Q |
0.768 |
|
| 2002 |
Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5. PMID 11856036 DOI: 10.1021/Jo016140O |
0.761 |
|
| 2002 |
Kehoe JW, Maly DJ, Verdugo DE, Armstrong JI, Cook BN, Ouyang YB, Moore KL, Ellman JA, Bertozzi CR. Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. Bioorganic & Medicinal Chemistry Letters. 12: 329-32. PMID 11814789 DOI: 10.1016/S0960-894X(01)00744-2 |
0.63 |
|
| 2002 |
Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. Journal of Virology. 76: 1359-68. PMID 11773410 DOI: 10.1128/Jvi.76.3.1359-1368.2002 |
0.546 |
|
| 2000 |
Maly DJ, Choong IC, Ellman JA. Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 97: 2419-24. PMID 10716979 DOI: 10.1073/Pnas.97.6.2419 |
0.812 |
|
| 1998 |
Mann DA, Kanai M, Maly DJ, Kiessling LL. Probing low affinity and multivalent interactions with surface plasmon resonance: Ligands for concanavalin A Journal of the American Chemical Society. 120: 10575-10582. DOI: 10.1021/Ja9818506 |
0.484 |
|
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