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Raquel L. Lieberman, Ph.D. - Publications

Affiliations: 
Northwestern University, Evanston, IL 
 Chemistry and Biochemistry Georgia Institute of Technology, Atlanta, GA 
Area:
bionorganic chemistry, protein crystallography
Website:
https://www.chemistry.gatech.edu/faculty/lieberman/
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Johnson AM, Huard DJE, Kim J, Raut P, Dai S, Lieberman RL, Glass JB. Mainly on the Plane: Deep Subsurface Bacterial Proteins Bind and Alter Clathrate Structure. Crystal Growth & Design. 20: 6290-6295. PMID 33414686 DOI: 10.1021/Acs.Cgd.0C00855  0.319
2020 Raut P, Glass JB, Lieberman RL. Archaeal roots of intramembrane aspartyl protease siblings signal peptide peptidase and presenilin. Proteins. PMID 32935885 DOI: 10.1002/Prot.26009  0.31
2020 Mascuch SJ, Fakhretaha-Aval S, Bowman JC, Ma MTH, Thomas G, Bommarius B, Ito C, Zhao L, Newnam GP, Matange KR, Thapa HR, Barlow B, Donegan RK, Nguyen NA, Saccuzzo EG, ... ... Lieberman RL, et al. A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits. The Journal of Biological Chemistry. PMID 32883809 DOI: 10.1074/Jbc.Ra120.015434  0.736
2020 Mascuch SJ, Fakhretaha-Aval S, Bowman JC, Ma MTH, Thomas G, Bommarius B, Ito C, Zhao L, Newnam GP, Matange KR, Thapa HR, Barlow B, Donegan RK, Nguyen NA, Saccuzzo EG, ... ... Lieberman RL, et al. Buzz about RT-qPCR: An RT-qPCR formulation for SARS-CoV-2 detection using reagents produced at Georgia Institute of Technology. Medrxiv : the Preprint Server For Health Sciences. PMID 32766604 DOI: 10.1101/2020.07.29.20163949  0.727
2020 Liu X, Zhao J, Zhang Y, Ubarretxena-Belandia I, Forth S, Lieberman RL, Wang C. Substrate-Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype. Frontiers in Molecular Neuroscience. 13: 65. PMID 32508589 DOI: 10.3389/Fnmol.2020.00065  0.342
2019 Huard DJE, Jonke AP, Torres MP, Lieberman RL. Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation. Scientific Reports. 9: 12769. PMID 31484937 DOI: 10.1038/S41598-019-48751-8  0.347
2019 Hill SE, Cho H, Raut P, Lieberman RL. Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices. Acta Crystallographica. Section D, Structural Biology. 75: 817-824. PMID 31478904 DOI: 10.1107/S205979831901074X  0.404
2019 Hill SE, Kwon MS, Martin MD, Suntharalingam A, Hazel A, Dickey CA, Gumbart JC, Lieberman RL. Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations. The Journal of Biological Chemistry. PMID 31270212 DOI: 10.1074/Jbc.Ra119.009419  0.397
2019 Lieberman RL. How does a protein's structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin. Plos Biology. 17: e3000237. PMID 31009450 DOI: 10.1371/Journal.Pbio.3000237  0.322
2019 Martínez-Bailén M, Carmona AT, Patterson-Orazem AC, Lieberman RL, Ide D, Kubo M, Kato A, Robina I, Moreno-Vargas AJ. Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition. Bioorganic Chemistry. 86: 652-664. PMID 30825709 DOI: 10.1016/J.Bioorg.2019.02.025  0.318
2019 Patterson-Orazem AC, Hill SE, Wang Y, Dominic IM, Hall CK, Lieberman RL. Differential misfolding properties of glaucoma-associated olfactomedin domains from human and mouse. Biochemistry. PMID 30802039 DOI: 10.1021/Acs.Biochem.8B01309  0.32
2018 Ashkar R, Bilheux HZ, Bordallo H, Briber R, Callaway DJE, Cheng X, Chu XQ, Curtis JE, Dadmun M, Fenimore P, Fushman D, Gabel F, Gupta K, Herberle F, Heinrich F, ... ... Lieberman R, et al. Neutron scattering in the biological sciences: progress and prospects. Acta Crystallographica. Section D, Structural Biology. 74: 1129-1168. PMID 30605130 DOI: 10.1107/S2059798318017503  0.569
2018 Oliver RC, Naing SH, Weiss KL, Pingali SV, Lieberman RL, Urban VS. Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling. Journal of Visualized Experiments : Jove. PMID 30394373 DOI: 10.3791/57901  0.344
2018 Naing SH, Oliver RC, Weiss KL, Urban VS, Lieberman RL. Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering. Biophysical Journal. 114: 602-608. PMID 29414706 DOI: 10.1016/J.Bpj.2017.12.017  0.334
2018 Huard DJ, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J, Blair L, Fu H, Blagg BSJ, Lieberman RL. Trifunctional high-throughput screen identifies promising scaffold to inhibit Grp94 and treat myocilin-associated glaucoma. Acs Chemical Biology. PMID 29402077 DOI: 10.1021/Acschembio.7B01083  0.346
2018 Naing SH, Kalyoncu S, Smalley DM, Kim H, Tao X, George JB, Jonke AP, Oliver RC, Urban VS, Torres MP, Lieberman RL. Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog. The Journal of Biological Chemistry. PMID 29382721 DOI: 10.1074/Jbc.Ra117.001436  0.32
2017 Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Scientific Reports. 7: 17951. PMID 29263415 DOI: 10.1038/S41598-017-18344-4  0.302
2017 Hill SE, Nguyen E, Donegan RK, Patterson-Orazem AC, Hazel A, Gumbart JC, Lieberman RL. Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin. Structure (London, England : 1993). PMID 29056483 DOI: 10.1016/J.Str.2017.09.008  0.768
2017 Crowley V, Huard D, Lieberman R, Blagg B. Second Generation Grp94-selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28857290 DOI: 10.1002/Chem.201703398  0.3
2017 Hill SE, Nguyen E, Ukachukwu CU, Freeman DM, Quirk S, Lieberman RL. Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism. Plos One. 12: e0180241. PMID 28742822 DOI: 10.1371/Journal.Pone.0180241  0.351
2016 Johnson JL, Kalyoncu S, Lieberman RL. Lessons from an α-Helical Membrane Enzyme: Expression, Purification, and Detergent Optimization for Biophysical and Structural Characterization. Methods in Molecular Biology (Clifton, N.J.). 1432: 281-301. PMID 27485343 DOI: 10.1007/978-1-4939-3637-3_18  0.312
2016 Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, et al. Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Molecular Cell. PMID 27425410 DOI: 10.1016/J.Molcel.2016.06.012  0.341
2016 Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Development of Glucose Regulated Protein 94-Selective Inhibitors based on the BnIm and Radamide Scaffold. Journal of Medicinal Chemistry. PMID 27003516 DOI: 10.1021/Acs.Jmedchem.6B00085  0.337
2015 Donegan RK, Lieberman RL. Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of Medicinal Chemistry. PMID 26356532 DOI: 10.1021/Acs.Jmedchem.5B00828  0.737
2015 Entzminger KC, Johnson JL, Hyun J, Lieberman RL, Maynard JA. Increased Fab thermoresistance via VH-targeted directed evolution. Protein Engineering, Design & Selection : Peds. PMID 26283664 DOI: 10.1093/Protein/Gzv037  0.334
2015 Hill SE, Donegan RK, Nguyen E, Desai TM, Lieberman RL. Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. Plos One. 10: e0130888. PMID 26121352 DOI: 10.1371/Journal.Pone.0130888  0.777
2015 Naing SH, Vukoti KM, Drury JE, Johnson JL, Kalyoncu S, Hill SE, Torres MP, Lieberman RL. Catalytic properties of intramembrane aspartyl protease substrate hydrolysis evaluated using a FRET peptide cleavage assay. Acs Chemical Biology. PMID 26118406 DOI: 10.1021/Acschembio.5B00305  0.316
2015 Johnson JL, Entzminger KC, Hyun J, Kalyoncu S, Heaner DP, Morales IA, Sheppard A, Gumbart JC, Maynard JA, Lieberman RL. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization. Acta Crystallographica. Section D, Biological Crystallography. 71: 896-906. PMID 25849400 DOI: 10.1107/S1399004715001856  0.364
2015 Donegan RK, Hill SE, Freeman DM, Nguyen E, Orwig SD, Turnage KC, Lieberman RL. Structural basis for misfolding in myocilin-associated glaucoma. Human Molecular Genetics. 24: 2111-24. PMID 25524706 DOI: 10.1093/Hmg/Ddu730  0.779
2014 Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma. Human Molecular Genetics. 23: 6470-80. PMID 25027323 DOI: 10.1093/Hmg/Ddu367  0.343
2014 Yu Y, Mena-Barragán T, Higaki K, Johnson JL, Drury JE, Lieberman RL, Nakasone N, Ninomiya H, Tsukimura T, Sakuraba H, Suzuki Y, Nanba E, Mellet CO, García Fernández JM, Ohno K. Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants. Acs Chemical Biology. 9: 1460-9. PMID 24783948 DOI: 10.1021/Cb500143H  0.321
2014 Kalyoncu S, Hyun J, Pai JC, Johnson JL, Entzminger K, Jain A, Heaner DP, Morales IA, Truskett TM, Maynard JA, Lieberman RL. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments. Proteins. 82: 1884-95. PMID 24615866 DOI: 10.1002/Prot.24542  0.313
2014 Hill SE, Donegan RK, Lieberman RL. The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence. Journal of Molecular Biology. 426: 921-35. PMID 24333014 DOI: 10.1016/J.Jmb.2013.12.002  0.759
2014 Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. Acs Chemical Biology. 9: 517-25. PMID 24279319 DOI: 10.1021/Cb4007776  0.386
2014 Kalyoncu S, Johnson JL, Heaner DP, Morales IA, Hyun J, Pai JC, Etzminger K, Maynard JA, Lieberman RL. The Use of Engineered Antibody Fragments to Promote Crystallization of Membrane Proteins Biophysical Journal. 106: 46a. DOI: 10.1016/J.Bpj.2013.11.334  0.327
2013 Hill SE, Stafford LM, Chi PV, Lieberman RL. Non-Native Structural Properties of the Glaucoma-Associated Olfactomedin Domain of Myocilin Lead to Amyloid Fibrils Biophysical Journal. 104: 49a-50a. DOI: 10.1016/J.Bpj.2012.11.314  0.387
2012 Donegan RK, Lieberman RL. New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin. Future Medicinal Chemistry. 4: 2131-4. PMID 23190098 DOI: 10.4155/Fmc.12.132  0.743
2012 Donegan RK, Hill SE, Turnage KC, Orwig SD, Lieberman RL. The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein. The Journal of Biological Chemistry. 287: 43370-7. PMID 23129764 DOI: 10.1074/Jbc.M112.408906  0.759
2012 Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of Biological Chemistry. 287: 40661-9. PMID 23035116 DOI: 10.1074/Jbc.M112.384800  0.3
2012 Orwig SD, Perry CW, Kim LY, Turnage KC, Zhang R, Vollrath D, Schmidt-Krey I, Lieberman RL. Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin. Journal of Molecular Biology. 421: 242-55. PMID 22197377 DOI: 10.1016/J.Jmb.2011.12.016  0.365
2011 Lieberman RL. A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C. Enzyme Research. 2011: 973231. PMID 22145077 DOI: 10.4061/2011/973231  0.37
2011 Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 50: 10647-57. PMID 22047104 DOI: 10.1021/Bi201619Z  0.364
2011 Lieberman RL. Sneak peak at galactocerebrosidase, Krabbe disease's lysosomal hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 108: 15017-8. PMID 21896758 DOI: 10.1073/Pnas.1112653108  0.311
2011 Lieberman RL, Culver JA, Entzminger KC, Pai JC, Maynard JA. Crystallization chaperone strategies for membrane proteins. Methods (San Diego, Calif.). 55: 293-302. PMID 21854852 DOI: 10.1016/J.Ymeth.2011.08.004  0.333
2011 Burns JN, Turnage KC, Walker CA, Lieberman RL. The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder. Biochemistry. 50: 5824-33. PMID 21612213 DOI: 10.1021/Bi200231X  0.378
2011 Orwig SD, Lieberman RL. Biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma. Plos One. 6: e16347. PMID 21283635 DOI: 10.1371/Journal.Pone.0016347  0.399
2011 Pai JC, Culver JA, Drury JE, Motani RS, Lieberman RL, Maynard JA. Conversion of scFv peptide-binding specificity for crystal chaperone development. Protein Engineering, Design & Selection : Peds. 24: 419-28. PMID 21217145 DOI: 10.1093/Protein/Gzq120  0.364
2010 Burns JN, Orwig SD, Harris JL, Watkins JD, Vollrath D, Lieberman RL. Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones. Acs Chemical Biology. 5: 477-87. PMID 20334347 DOI: 10.1021/Cb900282E  0.353
2009 Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JM, Orwig SD, Kozakov D, Brenke R, Chuang GY, Beglov D, Vajda S, Petsko GA, Ringe D. Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. Journal of Computer-Aided Molecular Design. 23: 491-500. PMID 19521672 DOI: 10.1007/S10822-009-9283-2  0.736
2009 Lieberman RL, D'aquino JA, Ringe D, Petsko GA. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry. 48: 4816-27. PMID 19374450 DOI: 10.1021/Bi9002265  0.607
2007 Lieberman RL, Wolfe MS. From rhomboid function to structure and back again. Proceedings of the National Academy of Sciences of the United States of America. 104: 8199-200. PMID 17494772 DOI: 10.1073/Pnas.0702745104  0.356
2007 Lieberman RL, Wolfe MS. Membrane-embedded protease poses for photoshoot. Proceedings of the National Academy of Sciences of the United States of America. 104: 401-2. PMID 17213330 DOI: 10.1073/Pnas.0610236103  0.305
2007 Lieberman RL, Wustman BA, Huertas P, Powe AC, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA. Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. Nature Chemical Biology. 3: 101-7. PMID 17187079 DOI: 10.1038/Nchembio850  0.64
2006 Lieberman RL, Kondapalli KC, Shrestha DB, Hakemian AS, Smith SM, Telser J, Kuzelka J, Gupta R, Borovik AS, Lippard SJ, Hoffman BM, Rosenzweig AC, Stemmler TL. Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorganic Chemistry. 45: 8372-81. PMID 16999437 DOI: 10.1021/Ic060739V  0.713
2006 Lieberman RL, Rosenzweig AC. Biophysical and structural characterization of particulate methane monooxygenase Acs National Meeting Book of Abstracts. 231.  0.526
2005 Lieberman RL, Rosenzweig AC. The quest for the particulate methane monooxygenase active site. Dalton Transactions (Cambridge, England : 2003). 3390-6. PMID 16234916 DOI: 10.1039/B506651D  0.592
2005 Sommerhalter M, Lieberman RL, Rosenzweig AC. X-ray crystallography and biological metal centers: is seeing believing? Inorganic Chemistry. 44: 770-8. PMID 15859245 DOI: 10.1021/Ic0485256  0.59
2005 Lieberman RL, Rosenzweig AC. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane. Nature. 434: 177-82. PMID 15674245 DOI: 10.1038/Nature03311  0.596
2004 Lieberman RL, Rosenzweig AC. Biological methane oxidation: regulation, biochemistry, and active site structure of particulate methane monooxygenase. Critical Reviews in Biochemistry and Molecular Biology. 39: 147-64. PMID 15596549 DOI: 10.1080/10409230490475507  0.578
2004 Lieberman RL, Rosenzweig AC. Metal Ion Homeostasis Comprehensive Coordination Chemistry Ii. 8: 195-211. DOI: 10.1016/B0-08-043748-6/08136-6  0.474
2004 Lieberman RL, Rosenzweig AC. Metal Ion Homeostasis Comprehensive Coordination Chemistry Ii. 8: 195-211. DOI: 10.1016/B0-08-043748-6/08136-6  0.474
2004 Lieberman RL, Rosenzweig AC. Crystallographic trapping of a precatalytic enzyme complex provides new insight into dioxygen activation at a mononuclear copper center Chemtracts. 17: 562-568.  0.513
2003 Lieberman RL, Shrestha DB, Doan PE, Hoffman BM, Stemmler TL, Rosenzweig AC. Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster. Proceedings of the National Academy of Sciences of the United States of America. 100: 3820-5. PMID 12634423 DOI: 10.1073/Pnas.0536703100  0.586
2001 Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC. Crystal structure of a novel red copper protein from Nitrosomonas europaea. Biochemistry. 40: 5674-81. PMID 11341832 DOI: 10.1021/Bi0102611  0.602
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