Year |
Citation |
Score |
2021 |
Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, et al. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34786712 DOI: 10.1111/nyas.14710 |
0.549 |
|
2020 |
Donahue PS, Draut JW, Muldoon JJ, Edelstein HI, Bagheri N, Leonard JN. The COMET toolkit for composing customizable genetic programs in mammalian cells. Nature Communications. 11: 779. PMID 32034124 DOI: 10.1038/S41467-019-14147-5 |
0.328 |
|
2018 |
Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, et al. Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. Jci Insight. 3. PMID 29618663 DOI: 10.1172/Jci.Insight.98942 |
0.325 |
|
2018 |
Dolberg TB, Donahue PS, Leonard JN. Synthetic biology: Reframing cell therapy for cancer. Nature Chemical Biology. 14: 204-205. PMID 29443984 DOI: 10.1038/Nchembio.2573 |
0.354 |
|
2018 |
Hung ME, Lenzini SB, Stranford DM, Leonard JN. Enrichment of Extracellular Vesicle Subpopulations Via Affinity Chromatography. Methods in Molecular Biology (Clifton, N.J.). 1740: 109-124. PMID 29388139 DOI: 10.1007/978-1-4939-7652-2_9 |
0.317 |
|
2018 |
Younger AKD, Su PY, Shepard AJ, Udani SV, Cybulski TR, Tyo KEJ, Leonard JN. Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion. Protein Engineering, Design & Selection : Peds. PMID 29385546 DOI: 10.1093/Protein/Gzy001 |
0.303 |
|
2017 |
Muldoon JJ, Donahue PS, Dolberg TB, Leonard JN. Building with intent: technologies and principles for engineering mammalian cell-based therapies to sense and respond. Current Opinion in Biomedical Engineering. 4: 127-133. PMID 29450405 DOI: 10.1016/J.Cobme.2017.10.004 |
0.376 |
|
2017 |
Stranford DM, Leonard JN. Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy. Advances in Genetics. 98: 155-175. PMID 28942793 DOI: 10.1016/Bs.Adgen.2017.08.002 |
0.336 |
|
2017 |
Hartfield RM, Schwarz KA, Muldoon JJ, Bagheri N, Leonard JN. Multiplexing engineered receptors for multiparametric evaluation of environmental ligands. Acs Synthetic Biology. PMID 28771312 DOI: 10.1021/Acssynbio.6B00279 |
0.335 |
|
2017 |
Stranford D, Hung ME, Gargus E, Shah RN, Leonard JN. A systematic evaluation of factors affecting extracellular vesicle uptake by breast cancer cells. Tissue Engineering. Part A. PMID 28586292 DOI: 10.1089/Ten.Tea.2017.0158 |
0.303 |
|
2016 |
Schwarz KA, Daringer NM, Dolberg TB, Leonard JN. Rewiring human cellular input-output using modular extracellular sensors. Nature Chemical Biology. PMID 27941759 DOI: 10.1038/Nchembio.2253 |
0.353 |
|
2016 |
Younger AK, Dalvie NC, Rottinghaus AG, Leonard JN. Engineering modular biosensors to confer metabolite-responsive regulation of transcription. Acs Synthetic Biology. PMID 27744683 DOI: 10.1021/Acssynbio.6B00184 |
0.34 |
|
2016 |
Schwarz KA, Leonard JN. Engineering cell-based therapies to interface robustly with host physiology. Advanced Drug Delivery Reviews. PMID 27266446 DOI: 10.1016/J.Addr.2016.05.019 |
0.372 |
|
2016 |
Hung ME, Leonard JN. A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. Journal of Extracellular Vesicles. 5: 31027. PMID 27189348 DOI: 10.3402/Jev.V5.31027 |
0.355 |
|
2016 |
Hung ME, Leonard JN. 496. Elucidating Design Rules Governing Extracellular Vesicle-Mediated Therapeutic Protein Delivery Molecular Therapy. 24: S197. DOI: 10.1016/S1525-0016(16)33305-6 |
0.343 |
|
2015 |
Pitner RA, Scarpelli AH, Leonard JN. Regulation of Bacterial Gene Expression by Protease-Alleviated Spatial Sequestration (PASS). Acs Synthetic Biology. 4: 966-74. PMID 25822588 DOI: 10.1021/Sb500302Y |
0.326 |
|
2015 |
Hung ME, Leonard JN. Stabilization of exosome-targeting peptides via engineered glycosylation. The Journal of Biological Chemistry. 290: 8166-72. PMID 25657008 DOI: 10.1074/Jbc.M114.621383 |
0.306 |
|
2015 |
György B, Hung ME, Breakefield XO, Leonard JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annual Review of Pharmacology and Toxicology. 55: 439-64. PMID 25292428 DOI: 10.1146/Annurev-Pharmtox-010814-124630 |
0.364 |
|
2014 |
Leonard JN. The rise of mammals. Acs Synthetic Biology. 3: 878-9. PMID 25524093 DOI: 10.1021/Sb5003554 |
0.335 |
|
2014 |
Dudek RM, Chuang Y, Leonard JN. Engineered cell-based therapies: a vanguard of design-driven medicine. Advances in Experimental Medicine and Biology. 844: 369-91. PMID 25480651 DOI: 10.1007/978-1-4939-2095-2_18 |
0.382 |
|
2014 |
Corey SJ, Kimmel M, Leonard JN. Systems hematology: an introduction. Advances in Experimental Medicine and Biology. 844: 3-10. PMID 25480634 DOI: 10.1007/978-1-4939-2095-2_1 |
0.333 |
|
2014 |
Daringer NM, Dudek RM, Schwarz KA, Leonard JN. Modular extracellular sensor architecture for engineering mammalian cell-based devices. Acs Synthetic Biology. 3: 892-902. PMID 24611683 DOI: 10.1021/Sb400128G |
0.332 |
|
2014 |
Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 35: 2024-31. PMID 24309498 DOI: 10.1016/J.Biomaterials.2013.11.036 |
0.321 |
|
2014 |
Corey SJ, Kimmel M, Leonard JN. A systems biology approach to blood Advances in Experimental Medicine and Biology. 844. DOI: 10.1007/978-1-4939-2095_2 |
0.303 |
|
2013 |
Marcus ME, Leonard JN. FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver. Pharmaceuticals (Basel, Switzerland). 6: 659-80. PMID 23894228 DOI: 10.3390/Ph6050659 |
0.375 |
|
2011 |
Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM. TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection. Journal of Immunology (Baltimore, Md. : 1950). 186: 2422-9. PMID 21242525 DOI: 10.4049/Jimmunol.1002845 |
0.303 |
|
2010 |
Samuel-Abraham S, Leonard JN. Staying on message: design principles for controlling nonspecific responses to siRNA. The Febs Journal. 277: 4828-36. PMID 21078117 DOI: 10.1111/J.1742-4658.2010.07905.X |
0.39 |
|
2008 |
Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host & Microbe. 4: 484-94. PMID 18996348 DOI: 10.1016/J.Chom.2008.09.008 |
0.679 |
|
2008 |
Ricci C, Pastukh V, Leonard J, Turrens J, Wilson G, Schaffer D, Schaffer SW. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. American Journal of Physiology. Cell Physiology. 294: C413-22. PMID 18077603 DOI: 10.1152/Ajpcell.00362.2007 |
0.397 |
|
2007 |
Ashton RS, Peltier J, Fasano CA, O'Neill A, Leonard J, Temple S, Schaffer DV, Kane RS. High-throughput screening of gene function in stem cells using clonal microarrays. Stem Cells (Dayton, Ohio). 25: 2928-35. PMID 17673524 DOI: 10.1634/Stemcells.2007-0468 |
0.662 |
|
2007 |
Leonard JN, Ferstl P, Delgado A, Schaffer DV. Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus. Biotechnology and Bioengineering. 97: 1170-9. PMID 17252611 DOI: 10.1002/Bit.21355 |
0.536 |
|
2006 |
Leonard JN, Schaffer DV. Antiviral RNAi therapy: emerging approaches for hitting a moving target. Gene Therapy. 13: 532-40. PMID 16177819 DOI: 10.1038/Sj.Gt.3302645 |
0.584 |
|
2005 |
Leonard JN, Schaffer DV. Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape. Journal of Virology. 79: 1645-54. PMID 15650190 DOI: 10.1128/Jvi.79.3.1645-1654.2005 |
0.599 |
|
2005 |
Leonard JN, Schaffer DV. 1002. Therapeutic Design Principles for Achieving Long-Term Suppression of HIV-1 with RNA Interference Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.549 |
0.577 |
|
2005 |
Leonard JN, Schaffer DV, Ferstl P, Delgado A. 519. Selective Inactivation of Helper Adenovirus with High Hydrostatic Pressure for AAV-2 Vector Production Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.059 |
0.533 |
|
2005 |
Leonard JN, Ferstl P, Delgado A, Schaffer DV. Purification of Aav gene therapy vectors by selectively inactivating helper adenovirus using high hydrostatic pressure Aiche Annual Meeting, Conference Proceedings. 12143. |
0.448 |
|
2005 |
Leonard JN, Schaffer DV. Computational design of RNA interference gene therapy strategies to treat HIV-1 infections and block viral escape Aiche Annual Meeting, Conference Proceedings. 8356-8357. |
0.511 |
|
2004 |
Leonard JN, Schaffer DV. 547. Antiviral RNA Interference Strategies That Resist HIV Escape Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.463 |
0.583 |
|
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