Nathaniel J. Traaseth, Ph.D. - Publications

Affiliations: 
2007 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Chemical Biology; Physical Chemistry; Environmental Chemistry; Chemical Physics; Experimental Physical Chemistry

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li J, Sae Her A, Traaseth NJ. Site-specific resolution of anionic residues in proteins using solid-state NMR spectroscopy. Journal of Biomolecular Nmr. PMID 32514875 DOI: 10.1007/S10858-020-00323-Z  0.494
2020 Chen L, Marsiglia WM, Chen H, Katigbak J, Erdjument-Bromage H, Kemble DJ, Fu L, Ma J, Sun G, Zhang Y, Liang G, Neubert TA, Li X, Traaseth NJ, Mohammadi M. Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation. Nature Chemical Biology. PMID 31959966 DOI: 10.1038/S41589-019-0455-7  0.347
2020 Marsiglia WM, Qamra R, Jackson KM, Traaseth NJ. A CURE Biochemistry Laboratory Module to Study Protein–Protein Interactions by NMR Spectroscopy Journal of Chemical Education. 97: 437-442. DOI: 10.1021/Acs.Jchemed.9B00364  0.304
2019 Leninger M, Sae Her A, Traaseth NJ. Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations. Elife. 8. PMID 31637997 DOI: 10.7554/Elife.48909  0.395
2019 Marsiglia WM, Katigbak J, Zheng S, Mohammadi M, Zhang Y, Traaseth NJ. A Conserved Allosteric Pathway in Tyrosine Kinase Regulation. Structure (London, England : 1993). PMID 31204250 DOI: 10.1016/J.Str.2019.05.002  0.338
2019 Yang W, Lee JS, Leninger M, Windschuh J, Traaseth NJ, Jerschow A. Magnetization transfer in liposome and proteoliposome samples that mimic the protein and lipid composition of myelin. Nmr in Biomedicine. e4097. PMID 31058381 DOI: 10.1002/Nbm.4097  0.359
2019 Leninger M, Her AS, Traaseth NJ. Author response: Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations Elife. DOI: 10.7554/Elife.48909.019  0.414
2018 Leninger M, Marsiglia WM, Jerschow A, Traaseth NJ. Multiple frequency saturation pulses reduce CEST acquisition time for quantifying conformational exchange in biomolecules. Journal of Biomolecular Nmr. 71: 19-30. PMID 29796789 DOI: 10.1007/S10858-018-0186-1  0.376
2018 Banigan JR, Leninger M, Her AS, Traaseth NJ. Assessing Interactions Between a Polytopic Membrane Protein and Lipid Bilayers Using Differential Scanning Calorimetry and Solid-State NMR. The Journal of Physical Chemistry. B. PMID 29457729 DOI: 10.1021/Acs.Jpcb.8B00479  0.55
2018 Leninger M, Traaseth NJ. NMR Spectroscopy Approach to Study the Structure, Orientation, and Mechanism of the Multidrug Exporter EmrE. Methods in Molecular Biology (Clifton, N.J.). 1700: 83-96. PMID 29177827 DOI: 10.1007/978-1-4939-7454-2_6  0.42
2018 Abramov G, Traaseth NJ. Afterglow Solid-State NMR Spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 1688: 55-66. PMID 29151204 DOI: 10.1007/978-1-4939-7386-6_3  0.424
2018 Leninger M, Sae Her A, Mueller C, Banigan J, Traaseth N. Deciphering Transport Mechanisms of Bacterial Efflux Pumps using NMR Spectroscopy Biophysical Journal. 114: 206a-207a. DOI: 10.1016/J.Bpj.2017.11.1157  0.304
2017 Chen H, Marsiglia WM, Cho MK, Huang Z, Deng J, Blais SP, Gai W, Bhattacharya S, Neubert TA, Traaseth NJ, Mohammadi M. Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases. Elife. 6. PMID 28166054 DOI: 10.7554/Elife.21137  0.357
2017 Marsiglia WM, Chen H, Cho M, Mohammadi M, Traaseth NJ. Characterization of Disease Causing Mutations Associated with FGF Receptor Tyrosine Kinases using NMR Spectroscopy Biophysical Journal. 112: 64a. DOI: 10.1016/J.Bpj.2016.11.383  0.333
2017 Leninger M, Banigan JR, Abramov G, Traaseth NJ. Investigating the Structure of the Drug Transporter EmrE Biophysical Journal. 112: 22a-23a. DOI: 10.1016/J.Bpj.2016.11.156  0.412
2016 Craven TW, Cho MK, Traaseth NJ, Bonneau R, Kirshenbaum K. A Miniature Protein Stabilized by a Cation-π Interaction Network. Journal of the American Chemical Society. PMID 26812069 DOI: 10.1021/Jacs.5B10285  0.383
2016 Gayen A, Leninger M, Traaseth NJ. Protonation of a glutamate residue modulates the dynamics of the drug transporter EmrE. Nature Chemical Biology. PMID 26751516 DOI: 10.1038/Nchembio.1999  0.383
2016 Leninger M, Gayen A, Traaseth N. Probing the Secondary Active Transport Mechanism of the Bacterial Efflux Pump EmrE Biophysical Journal. 110: 135a-136a. DOI: 10.1016/J.Bpj.2015.11.776  0.406
2016 Marsiglia W, Chen H, Cho M, Mohammadi M, Traaseth NJ. NMR Experiments on Wild-Type and Mutant Fibroblast Growth Factor Receptor Kinases Reveal Conformational Dynamics Associated with Enzyme Activation Biophysical Journal. 110: 220a. DOI: 10.1016/J.Bpj.2015.11.1222  0.367
2015 Huang Z, Marsiglia WM, Basu Roy U, Rahimi N, Ilghari D, Wang H, Chen H, Gai W, Blais S, Neubert TA, Mansukhani A, Traaseth NJ, Li X, Mohammadi M. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Molecular Cell. PMID 26687682 DOI: 10.1016/J.Molcel.2015.11.010  0.337
2015 Banigan JR, Gayen A, Cho MK, Traaseth NJ. A structured loop modulates coupling between the substrate-binding and dimerization domains in the multidrug resistance transporter EmrE. The Journal of Biological Chemistry. 290: 805-14. PMID 25406320 DOI: 10.1074/Jbc.M114.601963  0.423
2015 Banigan JR, Gayen A, Traaseth NJ. Correlating lipid bilayer fluidity with sensitivity and resolution of polytopic membrane protein spectra by solid-state NMR spectroscopy. Biochimica Et Biophysica Acta. 1848: 334-41. PMID 24835018 DOI: 10.1016/J.Bbamem.2014.05.003  0.525
2015 Traaseth NJ, Banigan JR, Leninger M. Exploring Transporters within the Small Multidrug Resistance Family Using Solid-State NMR Spectroscopy Journal of Magnetic Resonance. 4: 551-560. DOI: 10.1002/9780470034590.Emrstm1413  0.424
2014 Cho MK, Gayen A, Banigan JR, Leninger M, Traaseth NJ. Intrinsic conformational plasticity of native EmrE provides a pathway for multidrug resistance. Journal of the American Chemical Society. 136: 8072-80. PMID 24856154 DOI: 10.1021/Ja503145X  0.506
2013 Gustavsson M, Verardi R, Mullen DG, Mote KR, Traaseth NJ, Gopinath T, Veglia G. Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban. Proceedings of the National Academy of Sciences of the United States of America. 110: 17338-43. PMID 24101520 DOI: 10.1073/Pnas.1303006110  0.784
2013 Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS. Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 15602-7. PMID 24019500 DOI: 10.1073/Pnas.1312473110  0.3
2013 Gayen A, Banigan JR, Traaseth NJ. Ligand-induced conformational changes of the multidrug resistance transporter EmrE probed by oriented solid-state NMR spectroscopy. Angewandte Chemie (International Ed. in English). 52: 10321-4. PMID 23939862 DOI: 10.1002/Anie.201303091  0.516
2013 Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M. Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations. Cell Reports. 4: 376-84. PMID 23871672 DOI: 10.1016/J.Celrep.2013.06.025  0.358
2013 Banigan JR, Gayen A, Traaseth NJ. Combination of ¹⁵N reverse labeling and afterglow spectroscopy for assigning membrane protein spectra by magic-angle-spinning solid-state NMR: application to the multidrug resistance protein EmrE. Journal of Biomolecular Nmr. 55: 391-9. PMID 23539118 DOI: 10.1007/S10858-013-9724-Z  0.54
2013 Gayen A, Banigan JR, Traaseth NJ. Back Cover: Ligand-Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid-State NMR Spectroscopy (Angew. Chem. Int. Ed. 39/2013) Angewandte Chemie International Edition. 52: 10390-10390. DOI: 10.1002/Anie.201306525  0.357
2013 Gayen A, Banigan JR, Traaseth NJ. Rücktitelbild: Ligand-Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid-State NMR Spectroscopy (Angew. Chem. 39/2013) Angewandte Chemie. 125: 10582-10582. DOI: 10.1002/Ange.201306525  0.354
2012 Verardi R, Traaseth NJ, Masterson LR, Vostrikov VV, Veglia G. Isotope labeling for solution and solid-state NMR spectroscopy of membrane proteins. Advances in Experimental Medicine and Biology. 992: 35-62. PMID 23076578 DOI: 10.1007/978-94-007-4954-2_3  0.808
2012 Traaseth NJ, Chao FA, Masterson LR, Mangia S, Garwood M, Michaeli S, Seelig B, Veglia G. Heteronuclear Adiabatic Relaxation Dispersion (HARD) for quantitative analysis of conformational dynamics in proteins. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 219: 75-82. PMID 22621977 DOI: 10.1016/J.Jmr.2012.03.024  0.739
2012 Banigan JR, Traaseth NJ. Utilizing afterglow magnetization from cross-polarization magic-angle-spinning solid-state NMR spectroscopy to obtain simultaneous heteronuclear multidimensional spectra. The Journal of Physical Chemistry. B. 116: 7138-44. PMID 22582831 DOI: 10.1021/Jp303269M  0.379
2012 Gustavsson M, Traaseth NJ, Veglia G. Probing ground and excited states of phospholamban in model and native lipid membranes by magic angle spinning NMR spectroscopy. Biochimica Et Biophysica Acta. 1818: 146-53. PMID 21839724 DOI: 10.1016/J.Bbamem.2011.07.040  0.692
2012 Gustavsson M, Verardi R, Traaseth NJ, Veglia G. Structure of the Phospholamban/Ca2+-ATPase Complex in Lipid Bilayers by Hybrid Solid-State NMR Methods Biophysical Journal. 102: 423a. DOI: 10.1016/J.Bpj.2011.11.2313  0.801
2012 Veglia G, Traaseth NJ, Shi L, Verardi R, Gopinath T, Gustavsson M. The hybrid solution/solid-state NMR method for membrane protein structure determination Comprehensive Biophysics. 1: 182-198. DOI: 10.1016/B978-0-12-374920-8.00115-6  0.759
2011 Gustavsson M, Traaseth NJ, Veglia G. Activating and deactivating roles of lipid bilayers on the Ca(2+)-ATPase/phospholamban complex. Biochemistry. 50: 10367-74. PMID 21992175 DOI: 10.1021/Bi200759Y  0.639
2011 Mote KR, Gopinath T, Traaseth NJ, Kitchen J, Gor'kov PL, Brey WW, Veglia G. Multidimensional oriented solid-state NMR experiments enable the sequential assignment of uniformly 15N labeled integral membrane proteins in magnetically aligned lipid bilayers. Journal of Biomolecular Nmr. 51: 339-46. PMID 21976256 DOI: 10.1007/S10858-011-9571-8  0.675
2011 Gaffarogullari EC, Masterson LR, Metcalfe EE, Traaseth NJ, Balatri E, Musa MM, Mullen D, Distefano MD, Veglia G. A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes. Journal of Molecular Biology. 411: 823-36. PMID 21740913 DOI: 10.1016/J.Jmb.2011.06.034  0.808
2011 Verardi R, Shi L, Traaseth NJ, Walsh N, Veglia G. Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proceedings of the National Academy of Sciences of the United States of America. 108: 9101-6. PMID 21576492 DOI: 10.1073/Pnas.1016535108  0.79
2011 Traaseth NJ, Veglia G. Frequency-selective heteronuclear dephasing and selective carbonyl labeling to deconvolute crowded spectra of membrane proteins by magic angle spinning NMR. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 211: 18-24. PMID 21482162 DOI: 10.1016/J.Jmr.2011.03.013  0.617
2011 Gustavsson M, Traaseth NJ, Karim CB, Lockamy EL, Thomas DD, Veglia G. Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase. Journal of Molecular Biology. 408: 755-65. PMID 21419777 DOI: 10.1016/J.Jmb.2011.03.015  0.691
2011 Shi L, Traaseth NJ, Verardi R, Gustavsson M, Gao J, Veglia G. Paramagnetic-based NMR restraints lift residual dipolar coupling degeneracy in multidomain detergent-solubilized membrane proteins. Journal of the American Chemical Society. 133: 2232-41. PMID 21287984 DOI: 10.1021/Ja109080T  0.788
2011 Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A. Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers. Biochimica Et Biophysica Acta. 1808: 34-40. PMID 20719234 DOI: 10.1016/J.Bbamem.2010.08.008  0.735
2011 Verardi R, Gustavsson M, Traaseth NJ, Veglia G. Structural Dynamics of Phosphorylated Pentameric Phospholamban in Lipid Membranes using a Combination of Solution and Solid-State NMR Spectroscopy Biophysical Journal. 100: 602a. DOI: 10.1016/J.Bpj.2010.12.3466  0.801
2011 Gustavsson M, Traaseth NJ, Verardi R, Veglia G. Structure and Topology of Phospholamban Bound to Ca2+-ATPase in Lipid Bilayers Studied by Hybrid NMR Methods Biophysical Journal. 100: 384a. DOI: 10.1016/J.Bpj.2010.12.2284  0.795
2010 Traaseth NJ, Gopinath T, Veglia G. On the performance of spin diffusion NMR techniques in oriented solids: prospects for resonance assignments and distance measurements from separated local field experiments. The Journal of Physical Chemistry. B. 114: 13872-80. PMID 20936833 DOI: 10.1021/Jp105718R  0.553
2010 Veglia G, Ha KN, Shi L, Verardi R, Traaseth NJ. What can we learn from a small regulatory membrane protein? Methods in Molecular Biology (Clifton, N.J.). 654: 303-19. PMID 20665273 DOI: 10.1007/978-1-60761-762-4_16  0.821
2010 Mangia S, Traaseth NJ, Veglia G, Garwood M, Michaeli S. Probing slow protein dynamics by adiabatic R(1rho) and R(2rho) NMR experiments. Journal of the American Chemical Society. 132: 9979-81. PMID 20590094 DOI: 10.1021/Ja1038787  0.572
2010 Gopinath T, Verardi R, Traaseth NJ, Veglia G. Sensitivity enhancement of separated local field experiments: application to membrane proteins. The Journal of Physical Chemistry. B. 114: 5089-95. PMID 20349983 DOI: 10.1021/Jp909778A  0.773
2010 Gopinath T, Traaseth NJ, Mote K, Veglia G. Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences. Journal of the American Chemical Society. 132: 5357-63. PMID 20345172 DOI: 10.1021/Ja905991S  0.652
2010 Traaseth NJ, Veglia G. Probing excited states and activation energy for the integral membrane protein phospholamban by NMR CPMG relaxation dispersion experiments. Biochimica Et Biophysica Acta. 1798: 77-81. PMID 19781521 DOI: 10.1016/J.Bbamem.2009.09.009  0.668
2010 Verardi R, Traaseth NJ, Shi L, Veglia G. Spectroscopic Investigation of Phosphorylated Pentameric Phospholamban Bound to the Sarcoplasmic Calcium ATPase Biophysical Journal. 98: 625a. DOI: 10.1016/J.Bpj.2009.12.3422  0.681
2010 Ha KN, Gustavsson M, Verardi R, Menard N, Traaseth NJ, Veglia G. Towards the Development of Rationally Designed Phospholamban Mutants For Treatment of Heart Failure Biophysical Journal. 98: 47a. DOI: 10.1016/J.Bpj.2009.12.270  0.792
2009 Shi L, Traaseth NJ, Verardi R, Cembran A, Gao J, Veglia G. A refinement protocol to determine structure, topology, and depth of insertion of membrane proteins using hybrid solution and solid-state NMR restraints. Journal of Biomolecular Nmr. 44: 195-205. PMID 19597943 DOI: 10.1007/S10858-009-9328-9  0.789
2009 Traaseth NJ, Shi L, Verardi R, Mullen DG, Barany G, Veglia G. Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proceedings of the National Academy of Sciences of the United States of America. 106: 10165-70. PMID 19509339 DOI: 10.1073/Pnas.0904290106  0.798
2009 Traaseth N, Verardi R, Shi L, Veglia G. Topology of Phospholamban when Bound to Ca2±ATPase by Solid-State NMR Biophysical Journal. 96: 431a-432a. DOI: 10.1016/J.Bpj.2008.12.2210  0.8
2009 Veglia G, Traaseth NJ, Verardi R, Shi L, Ha K. Hybrid Solution and Solid-State NMR Analysis of SERCA/Phospholamban Interactions in lipid membranes: From Structural Dynamics to Function Biophysical Journal. 96: 431a. DOI: 10.1016/J.Bpj.2008.12.2209  0.838
2009 Verardi R, Traaseth NJ, Gustavsson M, Ha KH, Veglia G. Solution and Solid-State NMR Analysis of Phosphorylated and Pseudo-Phosphorylated Phospholamban Biophysical Journal. 96: 431a. DOI: 10.1016/J.Bpj.2008.12.2208  0.761
2009 Shi L, Traaseth NJ, Verardi R, Veglia G. A Refinement Protocol to Define the Structure, Topology and Depth of Insertion of Membrane Proteins using Hybrid Solution/Solid-state NMR Restraints Biophysical Journal. 96: 431a. DOI: 10.1016/j.bpj.2008.12.2207  0.637
2008 Deng Y, Wang Y, Holtz B, Li J, Traaseth N, Veglia G, Stottrup BJ, Elde R, Pei D, Guo A, Zhu XY. Fluidic and air-stable supported lipid bilayer and cell-mimicking microarrays. Journal of the American Chemical Society. 130: 6267-71. PMID 18407640 DOI: 10.1021/Ja800049F  0.517
2008 Traaseth NJ, Verardi R, Veglia G. Asymmetric methyl group labeling as a probe of membrane protein homo-oligomers by NMR spectroscopy. Journal of the American Chemical Society. 130: 2400-1. PMID 18247624 DOI: 10.1021/Ja711499R  0.752
2008 Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G. Allosteric cooperativity in protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 105: 506-11. PMID 18178622 DOI: 10.1073/Pnas.0709214104  0.774
2008 Traaseth NJ, Ha KN, Verardi R, Shi L, Buffy JJ, Masterson LR, Veglia G. Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry. 47: 3-13. PMID 18081313 DOI: 10.1021/Bi701668V  0.791
2007 Ha KN, Traaseth NJ, Verardi R, Zamoon J, Cembran A, Karim CB, Thomas DD, Veglia G. Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics. The Journal of Biological Chemistry. 282: 37205-14. PMID 17908690 DOI: 10.1074/Jbc.M704056200  0.811
2007 Traaseth NJ, Verardi R, Torgersen KD, Karim CB, Thomas DD, Veglia G. Spectroscopic validation of the pentameric structure of phospholamban. Proceedings of the National Academy of Sciences of the United States of America. 104: 14676-81. PMID 17804809 DOI: 10.1073/Pnas.0701016104  0.796
2007 Gor'kov PL, Chekmenev EY, Li C, Cotten M, Buffy JJ, Traaseth NJ, Veglia G, Brey WW. Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 185: 77-93. PMID 17174130 DOI: 10.1016/J.Jmr.2006.11.008  0.578
2006 Traaseth NJ, Buffy JJ, Zamoon J, Veglia G. Structural dynamics and topology of phospholamban in oriented lipid bilayers using multidimensional solid-state NMR. Biochemistry. 45: 13827-34. PMID 17105201 DOI: 10.1021/Bi0607610  0.685
2006 Buffy JJ, Traaseth NJ, Mascioni A, Gor'kov PL, Chekmenev EY, Brey WW, Veglia G. Two-dimensional solid-state NMR reveals two topologies of sarcolipin in oriented lipid bilayers. Biochemistry. 45: 10939-46. PMID 16953579 DOI: 10.1021/Bi060728D  0.817
2006 Traaseth NJ, Thomas DD, Veglia G. Effects of Ser16 phosphorylation on the allosteric transitions of phospholamban/Ca(2+)-ATPase complex. Journal of Molecular Biology. 358: 1041-50. PMID 16564056 DOI: 10.1016/J.Jmb.2006.02.047  0.653
2006 Buffy JJ, Buck-Koehntop BA, Porcelli F, Traaseth NJ, Thomas DD, Veglia G. Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy. Journal of Molecular Biology. 358: 420-9. PMID 16519897 DOI: 10.1016/J.Jmb.2006.02.005  0.68
2005 Metcalfe EE, Traaseth NJ, Veglia G. Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban. Biochemistry. 44: 4386-96. PMID 15766268 DOI: 10.1021/Bi047571E  0.622
2004 Elfering SL, Haynes VL, Traaseth NJ, Ettl A, Giulivi C. Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase. American Journal of Physiology. Heart and Circulatory Physiology. 286: H22-9. PMID 14527943 DOI: 10.1152/Ajpheart.00766.2003  0.32
2003 Giulivi C, Traaseth NJ, Davies KJ. Tyrosine oxidation products: analysis and biological relevance. Amino Acids. 25: 227-32. PMID 14661086 DOI: 10.1007/S00726-003-0013-0  0.321
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