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Joseph D. Mougous, Ph.D. - Publications

Affiliations: 
2004 University of California, Berkeley, Berkeley, CA, United States 
 2014 Harvard University, Cambridge, MA, United States 
 2015- University of Washington, Seattle, Seattle, WA 
Area:
Bioorthogonal chemistry
Website:
https://microbiology.washington.edu/users/joseph-d-mougous
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, McLean JS, Cong Q, Baker D, Baliga NS, Peterson SB, ... Mougous JD, et al. Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle. Cell. PMID 37683634 DOI: 10.1016/j.cell.2023.08.017  0.758
2023 Wang Y, Ledvina HE, Tower CA, Kambarev S, Liu E, Charity JC, Kreuk LSM, Tang Q, Chen Q, Gallagher LA, Radey MC, Rerolle GF, Li Y, Penewit KM, Turkarslan S, ... ... Mougous JD, et al. Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species. Cell Host & Microbe. PMID 37453420 DOI: 10.1016/j.chom.2023.06.010  0.675
2023 Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, McLean JS, Cong Q, Baker D, Baliga NS, Peterson SB, ... Mougous JD, et al. Genetic manipulation of candidate phyla radiation bacteria provides functional insights into microbial dark matter. Biorxiv : the Preprint Server For Biology. PMID 37205512 DOI: 10.1101/2023.05.02.539146  0.761
2022 Cutler KJ, Stringer C, Lo TW, Rappez L, Stroustrup N, Brook Peterson S, Wiggins PA, Mougous JD. Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation. Nature Methods. 19: 1438-1448. PMID 36253643 DOI: 10.1038/s41592-022-01639-4  0.637
2022 Gallagher LA, Velazquez E, Peterson SB, Charity JC, Radey MC, Gebhardt MJ, Hsu F, Shull LM, Cutler KJ, Macareno K, de Moraes MH, Penewit KM, Kim J, Andrade PA, LaFramboise T, ... ... Mougous JD, et al. Genome-wide protein-DNA interaction site mapping in bacteria using a double-stranded DNA-specific cytosine deaminase. Nature Microbiology. 7: 844-855. PMID 35650286 DOI: 10.1038/s41564-022-01133-9  0.634
2022 Ting SY, LaCourse KD, Ledvina HE, Zhang R, Radey MC, Kulasekara HD, Somavanshi R, Bertolli SK, Gallagher LA, Kim J, Penewit KM, Salipante SJ, Xu L, Peterson SB, Mougous JD. Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism. Elife. 11. PMID 35175195 DOI: 10.7554/eLife.74658  0.306
2020 Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. PMID 32641830 DOI: 10.1038/S41586-020-2477-4  0.311
2020 Ramsey KM, Ledvina HE, Tresko TM, Wandzilak JM, Tower CA, Tallo T, Schramm CE, Peterson SB, Skerrett SJ, Mougous JD, Dove SL. Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis. Plos Pathogens. 16: e1008566. PMID 32492066 DOI: 10.1371/Journal.Ppat.1008566  0.391
2020 Ting SY, Martínez-García E, Huang S, Bertolli SK, Kelly KA, Cutler KJ, Su ED, Zhi H, Tang Q, Radey MC, Raffatellu M, Peterson SB, de Lorenzo V, Mougous JD. Targeted Depletion of Bacteria from Mixed Populations by Programmable Adhesion with Antagonistic Competitor Cells. Cell Host & Microbe. PMID 32470328 DOI: 10.1016/J.Chom.2020.05.006  0.732
2019 Ross BD, Verster AJ, Radey MC, Schmidtke DT, Pope CE, Hoffman LR, Hajjar AM, Peterson SB, Borenstein E, Mougous JD. Human gut bacteria contain acquired interbacterial defence systems. Nature. PMID 31666699 DOI: 10.1038/S41586-019-1708-Z  0.385
2018 Park YJ, Lacourse KD, Cambillau C, DiMaio F, Mougous JD, Veesler D. Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy. Nature Communications. 9: 5385. PMID 30568167 DOI: 10.2210/Pdb6N38/Pdb  0.367
2018 Ting SY, Bosch DE, Mangiameli SM, Radey MC, Huang S, Park YJ, Kelly KA, Filip SK, Goo YA, Eng JK, Allaire M, Veesler D, Wiggins PA, Peterson SB, Mougous JD. Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins. Cell. PMID 30343895 DOI: 10.1016/J.Cell.2018.09.037  0.644
2018 Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S. Mechanism of loading and translocation of type VI secretion system effector Tse6. Nature Microbiology. PMID 30177742 DOI: 10.2210/Pdb6H3L/Pdb  0.359
2018 Ledvina HE, Kelly KA, Eshraghi A, Plemel RL, Peterson SB, Lee B, Steele S, Adler M, Kawula TH, Merz AJ, Skerrett SJ, Celli J, Mougous JD. A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella. Cell Host & Microbe. PMID 30057173 DOI: 10.1016/J.Chom.2018.07.003  0.636
2018 Ross BD, Hayes B, Radey MC, Lee X, Josek T, Bjork J, Neitzel D, Paskewitz S, Chou S, Mougous JD. Ixodes scapularis does not harbor a stable midgut microbiome. The Isme Journal. PMID 29946195 DOI: 10.1038/S41396-018-0161-6  0.378
2018 LaCourse KD, Peterson SB, Kulasekara HD, Radey MC, Kim J, Mougous JD. Conditional toxicity and synergy drive diversity among antibacterial effectors. Nature Microbiology. PMID 29459733 DOI: 10.1038/S41564-018-0113-Y  0.388
2017 Whitney JC, Peterson SB, Kim J, Pazos M, Verster AJ, Radey MC, Kulasekara HD, Ching MQ, Bullen NP, Bryant D, Goo YA, Surette MG, Borenstein E, Vollmer W, Mougous JD. A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. Elife. 6. PMID 28696203 DOI: 10.7554/Elife.26938  0.417
2017 Hood RD, Peterson SB, Mougous JD. From Striking Out to Striking Gold: Discovering that Type VI Secretion Targets Bacteria. Cell Host & Microbe. 21: 286-289. PMID 28279332 DOI: 10.1016/J.Chom.2017.02.001  0.405
2016 Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, ... ... Mougous JD, et al. Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth. Cell Host & Microbe. 20: 573-583. PMID 27832588 DOI: 10.1016/J.Chom.2016.10.008  0.649
2016 Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL. Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proceedings of the National Academy of Sciences of the United States of America. PMID 26957597 DOI: 10.1073/Pnas.1525637113  0.366
2015 Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD. An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells. Cell. 163: 607-19. PMID 26456113 DOI: 10.1016/J.Cell.2015.09.027  0.405
2015 LeRoux M, Peterson SB, Mougous JD. Bacterial danger sensing. Journal of Molecular Biology. PMID 26434507 DOI: 10.1016/J.Jmb.2015.09.018  0.365
2015 McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL. A self-lysis pathway that enhances the virulence of a pathogenic bacterium. Proceedings of the National Academy of Sciences of the United States of America. 112: 8433-8. PMID 26100878 DOI: 10.1073/Pnas.1506299112  0.401
2015 LeRoux M, Kirkpatrick RL, Montauti EI, Tran BQ, Peterson SB, Harding BN, Whitney JC, Russell AB, Traxler B, Goo YA, Goodlett DR, Wiggins PA, Mougous JD. Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa. Elife. 4. PMID 25643398 DOI: 10.7554/Elife.05701  0.312
2015 Chou S, Daugherty MD, Peterson SB, Biboy J, Yang Y, Jutras BL, Fritz-Laylin LK, Ferrin MA, Harding BN, Jacobs-Wagner C, Yang XF, Vollmer W, Malik HS, Mougous JD. Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature. 518: 98-101. PMID 25470067 DOI: 10.1038/Nature13965  0.393
2015 Corbitt J, LeRoux M, Kirkpatrick R, Mougous J, Wiggins PA. Dissecting the Mechanism of Type VI Secretion System Effector Delivery by Fluorescence Cross-Correlation Microscopy Biophysical Journal. 108: 600a. DOI: 10.1016/J.Bpj.2014.11.3267  0.409
2014 Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD. A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism. Cell Host & Microbe. 16: 227-36. PMID 25070807 DOI: 10.1016/J.Chom.2014.07.007  0.441
2014 Whitney JC, Beck CM, Goo YA, Russell AB, Harding BN, De Leon JA, Cunningham DA, Tran BQ, Low DA, Goodlett DR, Hayes CS, Mougous JD. Genetically distinct pathways guide effector export through the type VI secretion system. Molecular Microbiology. 92: 529-42. PMID 24589350 DOI: 10.1111/Mmi.12571  0.419
2014 Schwarz S, Singh P, Robertson JD, LeRoux M, Skerrett SJ, Goodlett DR, West TE, Mougous JD. VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence. Infection and Immunity. 82: 1445-52. PMID 24452686 DOI: 10.1128/Iai.01368-13  0.425
2014 Russell AB, Peterson SB, Mougous JD. Type VI secretion system effectors: poisons with a purpose. Nature Reviews. Microbiology. 12: 137-48. PMID 24384601 DOI: 10.1038/Nrmicro3185  0.36
2014 Corbitt J, Leroux M, Mougous J, Wiggins P. A View to a Kill: T6SS-Mediated Cell Killing Visualized by Fluorescence Microscopy Biophysical Journal. 106: 55a. DOI: 10.1016/J.Bpj.2013.11.384  0.406
2013 Silverman JM, Agnello DM, Zheng H, Andrews BT, Li M, Catalano CE, Gonen T, Mougous JD. Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. Molecular Cell. 51: 584-93. PMID 23954347 DOI: 10.1016/J.Molcel.2013.07.025  0.43
2013 Whitney JC, Chou S, Russell AB, Biboy J, Gardiner TE, Ferrin MA, Brittnacher M, Vollmer W, Mougous JD. Identification, structure, and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector-immunity pair. The Journal of Biological Chemistry. 288: 26616-24. PMID 23878199 DOI: 10.1074/Jbc.M113.488320  0.411
2013 Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD. Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. Nature. 496: 508-12. PMID 23552891 DOI: 10.1038/Nature12074  0.432
2013 Casabona MG, Silverman JM, Sall KM, Boyer F, Couté Y, Poirel J, Grunwald D, Mougous JD, Elsen S, Attree I. An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in Pseudomonas aeruginosa. Environmental Microbiology. 15: 471-86. PMID 22765374 DOI: 10.1111/J.1462-2920.2012.02816.X  0.331
2012 LeRoux M, De Leon JA, Kuwada NJ, Russell AB, Pinto-Santini D, Hood RD, Agnello DM, Robertson SM, Wiggins PA, Mougous JD. Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword. Proceedings of the National Academy of Sciences of the United States of America. 109: 19804-9. PMID 23150540 DOI: 10.1073/Pnas.1213963109  0.413
2012 Chou S, Bui NK, Russell AB, Lexa KW, Gardiner TE, LeRoux M, Vollmer W, Mougous JD. Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system. Cell Reports. 1: 656-64. PMID 22813741 DOI: 10.1016/J.Celrep.2012.05.016  0.389
2012 Silverman JM, Brunet YR, Cascales E, Mougous JD. Structure and regulation of the type VI secretion system. Annual Review of Microbiology. 66: 453-72. PMID 22746332 DOI: 10.1146/Annurev-Micro-121809-151619  0.391
2012 Russell AB, Singh P, Brittnacher M, Bui NK, Hood RD, Carl MA, Agnello DM, Schwarz S, Goodlett DR, Vollmer W, Mougous JD. A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host & Microbe. 11: 538-49. PMID 22607806 DOI: 10.1016/J.Chom.2012.04.007  0.437
2012 Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD. Structural basis for type VI secretion effector recognition by a cognate immunity protein. Plos Pathogens. 8: e1002613. PMID 22511866 DOI: 10.1371/Journal.Ppat.1002613  0.411
2011 Silverman JM, Austin LS, Hsu F, Hicks KG, Hood RD, Mougous JD. Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation. Molecular Microbiology. 82: 1277-90. PMID 22017253 DOI: 10.1111/J.1365-2958.2011.07889.X  0.395
2011 Russell AB, Hood RD, Bui NK, LeRoux M, Vollmer W, Mougous JD. Type VI secretion delivers bacteriolytic effectors to target cells. Nature. 475: 343-7. PMID 21776080 DOI: 10.1038/Nature10244  0.439
2010 Schwarz S, Hood RD, Mougous JD. What is type VI secretion doing in all those bugs? Trends in Microbiology. 18: 531-7. PMID 20961764 DOI: 10.1016/J.Tim.2010.09.001  0.416
2010 Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD. Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. Plos Pathogens. 6: e1001068. PMID 20865170 DOI: 10.1371/Journal.Ppat.1001068  0.412
2010 Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, ... Mougous JD, et al. A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host & Microbe. 7: 25-37. PMID 20114026 DOI: 10.1016/J.Chom.2009.12.007  0.441
2009 Wollack JW, Silverman JM, Petzold CJ, Mougous JD, Distefano MD. A minimalist substrate for enzymatic peptide and protein conjugation. Chembiochem : a European Journal of Chemical Biology. 10: 2934-43. PMID 19856367 DOI: 10.1002/Cbic.200900566  0.304
2009 Yang JC, Madupu R, Durkin AS, Ekborg NA, Pedamallu CS, Hostetler JB, Radune D, Toms BS, Henrissat B, Coutinho PM, Schwarz S, Field L, Trindade-Silva AE, Soares CA, Elshahawi S, ... ... Mougous JD, et al. The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). Plos One. 4: e6085. PMID 19568419 DOI: 10.1371/Journal.Pone.0006085  0.359
2009 Hsu F, Schwarz S, Mougous JD. TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa. Molecular Microbiology. 72: 1111-25. PMID 19400797 DOI: 10.1111/J.1365-2958.2009.06701.X  0.359
2007 Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ. Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nature Cell Biology. 9: 797-803. PMID 17558395 DOI: 10.1038/Ncb1605  0.359
2007 Senaratne RH, Mougous JD, Reader JR, Williams SJ, Zhang T, Bertozzi CR, Riley LW. Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. Journal of Medical Microbiology. 56: 454-8. PMID 17374883 DOI: 10.1099/Jmm.0.46983-0  0.585
2007 Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi CR, Leary JA, Cox JS. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proceedings of the National Academy of Sciences of the United States of America. 104: 5133-8. PMID 17360366 DOI: 10.1073/Pnas.0610634104  0.76
2006 Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science (New York, N.Y.). 312: 1526-30. PMID 16763151 DOI: 10.1126/Science.1128393  0.405
2006 Senaratne RH, De Silva AD, Williams SJ, Mougous JD, Reader JR, Zhang T, Chan S, Sidders B, Lee DH, Chan J, Bertozzi CR, Riley LW. 5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice. Molecular Microbiology. 59: 1744-53. PMID 16553880 DOI: 10.1111/J.1365-2958.2006.05075.X  0.614
2006 Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi CR. A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 4258-63. PMID 16537518 DOI: 10.1073/Pnas.0510861103  0.773
2006 Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Molecular Cell. 21: 109-22. PMID 16387658 DOI: 10.1016/J.Molcel.2005.10.034  0.728
2005 Pi N, Hoang MB, Gao H, Mougous JD, Bertozzi CR, Leary JA. Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry. Analytical Biochemistry. 341: 94-104. PMID 15866533 DOI: 10.1016/J.Ab.2005.02.004  0.543
2004 Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi CR. Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nature Structural & Molecular Biology. 11: 721-9. PMID 15258569 DOI: 10.1038/Nsmb802  0.67
2004 Woodruff PJ, Carlson BL, Siridechadilok B, Pratt MR, Senaratne RH, Mougous JD, Riley LW, Williams SJ, Bertozzi CR. Trehalose is required for growth of Mycobacterium smegmatis. The Journal of Biological Chemistry. 279: 28835-43. PMID 15102847 DOI: 10.1074/Jbc.M313103200  0.743
2004 Pi N, Yu Y, Mougous JD, Leary JA. Observation of a hybrid random ping-pong mechanism of catalysis for NodST: a mass spectrometry approach. Protein Science : a Publication of the Protein Society. 13: 903-12. PMID 15044725 DOI: 10.1110/Ps.03581904  0.457
2003 Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi CR, Cox JS. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proceedings of the National Academy of Sciences of the United States of America. 100: 6121-6. PMID 12724526 DOI: 10.1073/Pnas.1030024100  0.583
2002 Mougous JD, Leavell MD, Senaratne RH, Leigh CD, Williams SJ, Riley LW, Leary JA, Bertozzi CR. Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach. Proceedings of the National Academy of Sciences of the United States of America. 99: 17037-42. PMID 12482950 DOI: 10.1073/Pnas.252514899  0.653
2002 Mougous JD, Green RE, Williams SJ, Brenner SE, Bertozzi CR. Sulfotransferases and sulfatases in mycobacteria. Chemistry & Biology. 9: 767-76. PMID 12144918 DOI: 10.1016/S1074-5521(02)00175-8  0.625
2002 Williams SJ, Senaratne RH, Mougous JD, Riley LW, Bertozzi CR. 5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria. The Journal of Biological Chemistry. 277: 32606-15. PMID 12072441 DOI: 10.1074/Jbc.M204613200  0.642
2002 Leavell MD, Mougous JD, Senaratne RH, Leigh C, Williams SJ, Riley L, Bertozzi CR, Leary JA. Strategy for the identification of sulfated metabolites in bacterial cell extracts using FT-ICR, isotopic labeling and genetics Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 415-416.  0.473
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