Jay Humphrey - Publications

Affiliations: 
Biomedical Engineering Yale University, New Haven, CT 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cuomo F, Ferruzzi J, Agarwal P, Li C, Zhuang ZW, Humphrey JD, Figueroa CA. Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing. Proceedings. Mathematical, Physical, and Engineering Sciences. 475: 20180076. PMID 30760948 DOI: 10.1098/rspa.2018.0076  0.68
2018 Ferruzzi J, Di Achille P, Tellides G, Humphrey JD. Combining in vivo and in vitro biomechanical data reveals key roles of perivascular tethering in central artery function. Plos One. 13: e0201379. PMID 30192758 DOI: 10.1371/journal.pone.0201379  0.68
2018 Best CA, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized biodegradable arterial grafts promote enhanced neointimal tissue formation. Tissue Engineering. Part A. PMID 29431029 DOI: 10.1089/ten.TEA.2017.0483  0.36
2017 Cuomo F, Roccabianca S, Dillon-Murphy D, Xiao N, Humphrey JD, Figueroa CA. Effects of age-associated regional changes in aortic stiffness on human hemodynamics revealed by computational modeling. Plos One. 12: e0173177. PMID 28253335 DOI: 10.1371/journal.pone.0173177  0.68
2016 Huang AH, Balestrini JL, Zhou K, Zhao L, Ferruzzi J, Starcher BC, Levene M, Humphrey JD, Niklason L. Biaxial stretch improves elastic fiber maturation, collagen arrangement and mechanical properties in engineered arteries. Tissue Engineering. Part C, Methods. PMID 27108525 DOI: 10.1089/ten.TEC.2015.0309  0.68
2016 Bersi MR, Bellini C, Wu J, Montaniel KR, Harrison DG, Humphrey JD. Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. Hypertension. PMID 27001298 DOI: 10.1161/HYPERTENSIONAHA.115.06262  0.68
2016 Ferruzzi J, Murtada SI, Li G, Jiao Y, Uman S, Ting MY, Tellides G, Humphrey JD. Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26988590 DOI: 10.1161/ATVBAHA.116.307436  0.68
2016 Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S. Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence. Circulation Research. 118: 379-81. PMID 26846637 DOI: 10.1161/CIRCRESAHA.115.307722  0.68
2016 Khosravi R, Best CA, Allen RA, Stowell CE, Onwuka E, Zhuang JJ, Lee YU, Yi T, Bersi MR, Shinoka T, Humphrey JD, Wang Y, Breuer CK. Long-Term Functional Efficacy of a Novel Electrospun Poly(Glycerol Sebacate)-Based Arterial Graft in Mice. Annals of Biomedical Engineering. PMID 26795977 DOI: 10.1007/s10439-015-1545-7  0.68
2016 Ferruzzi J, Bersi MR, Mecham RP, Ramirez F, Yanagisawa H, Tellides G, Humphrey JD. Loss of elastic fiber integrity compromises common carotid artery function: Implications for vascular aging Artery Research. 14: 41-52. DOI: 10.1016/j.artres.2016.04.001  0.68
2016 Cyron CJ, Aydin RC, Humphrey JD. A homogenized constrained mixture (and mechanical analog) model for growth and remodeling of soft tissue Biomechanics and Modeling in Mechanobiology. 1-15. DOI: 10.1007/s10237-016-0770-9  0.68
2016 Humphrey JD. From stress–strain relations to growth and remodeling theories: A historical reflection on microstructurally motivated constitutive relations Structure-Based Mechanics of Tissues and Organs. 123-133. DOI: 10.1007/978-1-4899-7630-7_7  0.68
2015 Khosravi R, Miller KS, Best CA, Shih YC, Lee YU, Yi T, Shinoka T, Breuer CK, Humphrey JD. Biomechanical diversity despite mechanobiological stability in tissue engineered vascular grafts two years post-implantation. Tissue Engineering. Part A. 21: 1529-38. PMID 25710791 DOI: 10.1089/ten.tea.2014.0524  0.68
2015 Cuomo F, Ferruzzi J, Humphrey JD, Figueroa CA. An Experimental-Computational Study of Catheter Induced Alterations in Pulse Wave Velocity in Anesthetized Mice. Annals of Biomedical Engineering. 43: 1555-70. PMID 25698526 DOI: 10.1007/s10439-015-1272-0  0.68
2015 Ferruzzi J, Bersi MR, Uman S, Yanagisawa H, Humphrey JD. Decreased elastic energy storage, not increased material stiffness, characterizes central artery dysfunction in fibulin-5 deficiency independent of sex. Journal of Biomechanical Engineering. 137. PMID 25532020 DOI: 10.1115/1.4029431  0.68
2015 Sorrentino TA, Fourman L, Ferruzzi J, Miller KS, Humphrey JD, Roccabianca S. Local versus global mechanical effects of intramural swelling in carotid arteries. Journal of Biomechanical Engineering. 137: 041008. PMID 25474096 DOI: 10.1115/1.4029303  0.68
2015 Ramachandra AB, Sankaran S, Humphrey JD, Marsden AL. Computational simulation of the adaptive capacity of vein grafts in response to increased pressure. Journal of Biomechanical Engineering. 137. PMID 25376151 DOI: 10.1115/1.4029021  0.68
2015 Miller KS, Khosravi R, Breuer CK, Humphrey JD. A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation. Acta Biomaterialia. 11: 283-94. PMID 25288519 DOI: 10.1016/j.actbio.2014.09.046  0.68
2015 Cyron CJ, Humphrey JD. Preferred fiber orientations in healthy arteries and veins understood from netting analysis Mathematics and Mechanics of Solids. 20: 680-696. DOI: 10.1177/1081286514551495  0.68
2015 Avril S, Bersi MR, Bellini C, Genovese K, Humphrey JD. Regional identification of mechanical properties in arteries Computer Methods in Biomechanics and Biomedical Engineering. 18: 1874-1875. DOI: 10.1080/10255842.2015.1070577  0.68
2015 Bellini C, Korneva A, Zilberberg L, Ramirez F, Rifkin DB, Humphrey JD. Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome Journal of Biomechanics. DOI: 10.1016/j.jbiomech.2015.11.059  0.68
2015 Humphrey JD, O'Rourke SL. An introduction to biomechanics: Solids and fluids, analysis and design, second edition An Introduction to Biomechanics: Solids and Fluids, Analysis and Design, Second Edition. 1-692. DOI: 10.1007/978-1-4939-2623-7  0.68
2014 Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 17308-13. PMID 25404299 DOI: 10.1073/pnas.1413725111  0.68
2014 Cyron CJ, Humphrey JD. Vascular homeostasis and the concept of mechanobiological stability. International Journal of Engineering Science. 85: 203-223. PMID 25308990 DOI: 10.1016/j.ijengsci.2014.08.003  0.68
2014 Cyron CJ, Wilson JS, Humphrey JD. Mechanobiological stability: a new paradigm to understand the enlargement of aneurysms? Journal of the Royal Society, Interface / the Royal Society. 11: 20140680. PMID 25209402 DOI: 10.1098/rsif.2014.0680  0.68
2014 Simon DD, Murtada SI, Humphrey JD. Computational model of matrix remodeling and entrenchment in the free-floating fibroblast-populated collagen lattice. International Journal For Numerical Methods in Biomedical Engineering. 30: 1506-29. PMID 25178626 DOI: 10.1002/cnm.2669  0.68
2014 Wilson JS, Humphrey JD. Evolving anisotropy and degree of elastolytic insult in abdominal aortic aneurysms: potential clinical relevance? Journal of Biomechanics. 47: 2995-3002. PMID 25086482 DOI: 10.1016/j.jbiomech.2014.07.003  0.68
2014 Roccabianca S, Bellini C, Humphrey JD. Computational modelling suggests good, bad and ugly roles of glycosaminoglycans in arterial wall mechanics and mechanobiology. Journal of the Royal Society, Interface / the Royal Society. 11: 20140397. PMID 24920112 DOI: 10.1098/rsif.2014.0397  0.68
2014 Bai Y, Lee PF, Humphrey JD, Yeh AT. Sequential multimodal microscopic imaging and biaxial mechanical testing of living multicomponent tissue constructs. Annals of Biomedical Engineering. 42: 1791-805. PMID 24817419 DOI: 10.1007/s10439-014-1019-3  0.68
2014 Humphrey JD, Milewicz DM, Tellides G, Schwartz MA. Cell biology. Dysfunctional mechanosensing in aneurysms. Science (New York, N.Y.). 344: 477-9. PMID 24786066 DOI: 10.1126/science.1253026  0.68
2014 Udelsman BV, Khosravi R, Miller KS, Dean EW, Bersi MR, Rocco K, Yi T, Humphrey JD, Breuer CK. Characterization of evolving biomechanical properties of tissue engineered vascular grafts in the arterial circulation. Journal of Biomechanics. 47: 2070-9. PMID 24702863 DOI: 10.1016/j.jbiomech.2014.03.011  0.68
2014 Bersi MR, Ferruzzi J, Eberth JF, Gleason RL, Humphrey JD. Consistent biomechanical phenotyping of common carotid arteries from seven genetic, pharmacological, and surgical mouse models. Annals of Biomedical Engineering. 42: 1207-23. PMID 24590490 DOI: 10.1007/s10439-014-0988-6  0.68
2014 Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, Ferruzzi J, Kim RW, Geirsson A, Dietz HC, Offermanns S, Humphrey JD, Tellides G. Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. The Journal of Clinical Investigation. 124: 755-67. PMID 24401272 DOI: 10.1172/JCI69942  0.68
2014 Miller KS, Lee YU, Naito Y, Breuer CK, Humphrey JD. Computational model of the in vivo development of a tissue engineered vein from an implanted polymeric construct. Journal of Biomechanics. 47: 2080-7. PMID 24210474 DOI: 10.1016/j.jbiomech.2013.10.009  0.68
2014 Bellini C, Ferruzzi J, Roccabianca S, Di Martino ES, Humphrey JD. A microstructurally motivated model of arterial wall mechanics with mechanobiological implications. Annals of Biomedical Engineering. 42: 488-502. PMID 24197802 DOI: 10.1007/s10439-013-0928-x  0.68
2014 Naito Y, Lee YU, Yi T, Church SN, Solomon D, Humphrey JD, Shin'oka T, Breuer CK. Beyond burst pressure: initial evaluation of the natural history of the biaxial mechanical properties of tissue-engineered vascular grafts in the venous circulation using a murine model. Tissue Engineering. Part A. 20: 346-55. PMID 23957852 DOI: 10.1089/ten.TEA.2012.0613  0.68
2014 Roccabianca S, Figueroa CA, Tellides G, Humphrey JD. Quantification of regional differences in aortic stiffness in the aging human. Journal of the Mechanical Behavior of Biomedical Materials. 29: 618-34. PMID 23499251 DOI: 10.1016/j.jmbbm.2013.01.026  0.68
2014 Roccabianca S, Ateshian GA, Humphrey JD. Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection. Biomechanics and Modeling in Mechanobiology. 13: 13-25. PMID 23494585 DOI: 10.1007/s10237-013-0482-3  0.68
2014 Di Achille P, Tellides G, Figueroa CA, Humphrey JD. A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms Proceedings of the Royal Society a: Mathematical, Physical and Engineering Sciences. 470. DOI: 10.1098/rspa.2014.0163  0.68
2014 Genovese K, Casaletto L, Humphrey JD, Lu J. Digital image correlation-based point-wise inverse characterization of heterogeneous material properties of gallbladder in vitro Proceedings of the Royal Society a: Mathematical, Physical and Engineering Sciences. 470. DOI: 10.1098/rspa.2014.0152  0.68
2013 Humphrey JD. Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β. Author reply. Journal of Vascular Research. 50: 198-9. PMID 24040670 DOI: 10.1159/000349912  0.68
2013 Lee YU, Naito Y, Kurobe H, Breuer CK, Humphrey JD. Biaxial mechanical properties of the inferior vena cava in C57BL/6 and CB-17 SCID/bg mice. Journal of Biomechanics. 46: 2277-82. PMID 23859752 DOI: 10.1016/j.jbiomech.2013.06.013  0.68
2013 Xiao N, Humphrey JD, Figueroa CA. Multi-Scale Computational Model of Three-Dimensional Hemodynamics within a Deformable Full-Body Arterial Network. Journal of Computational Physics. 244: 22-40. PMID 23729840 DOI: 10.1016/j.jcp.2012.09.016  0.68
2013 Valentín A, Humphrey JD, Holzapfel GA. A finite element-based constrained mixture implementation for arterial growth, remodeling, and adaptation: theory and numerical verification. International Journal For Numerical Methods in Biomedical Engineering. 29: 822-49. PMID 23713058 DOI: 10.1002/cnm.2555  0.68
2013 Sankaran S, Humphrey JD, Marsden AL. An efficient framework for optimization and parameter sensitivity analysis in arterial growth and remodeling computations. Computer Methods in Applied Mechanics and Engineering. 256: 200-210. PMID 23626380 DOI: 10.1016/j.cma.2012.12.013  0.68
2013 Ferruzzi J, Bersi MR, Humphrey JD. Biomechanical phenotyping of central arteries in health and disease: advantages of and methods for murine models. Annals of Biomedical Engineering. 41: 1311-30. PMID 23549898 DOI: 10.1007/s10439-013-0799-1  0.68
2013 Genovese K, Lee YU, Lee AY, Humphrey JD. An improved panoramic digital image correlation method for vascular strain analysis and material characterization. Journal of the Mechanical Behavior of Biomedical Materials. 27: 132-42. PMID 23290821 DOI: 10.1016/j.jmbbm.2012.11.015  0.68
2013 Coogan JS, Humphrey JD, Figueroa CA. Computational simulations of hemodynamic changes within thoracic, coronary, and cerebral arteries following early wall remodeling in response to distal aortic coarctation. Biomechanics and Modeling in Mechanobiology. 12: 79-93. PMID 22415052 DOI: 10.1007/s10237-012-0383-x  0.68
2013 Ramachandra AB, Sankaran S, Humphrey JD, Marsden AL. Growth and remodeling of vein graft in an arterial environment: Parameter estimation and sensitivity analysis Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14617  0.68
2012 Zhang P, Huang A, Ferruzzi J, Mecham RP, Starcher BC, Tellides G, Humphrey JD, Giordano FJ, Niklason LE, Sessa WC. Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 756-9. PMID 22095981 DOI: 10.1161/ATVBAHA.111.238113  0.68
2012 Naito Y, Williams-Fritze M, Duncan DR, Church SN, Hibino N, Madri JA, Humphrey JD, Shinoka T, Breuer CK. Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation. Cells, Tissues, Organs. 195: 60-72. PMID 21996715 DOI: 10.1159/000331405  0.68
2011 Ferruzzi J, Collins MJ, Yeh AT, Humphrey JD. Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome. Cardiovascular Research. 92: 287-95. PMID 21730037 DOI: 10.1093/cvr/cvr195  0.68
2011 Masson I, Beaussier H, Boutouyrie P, Laurent S, Humphrey JD, Zidi M. Carotid artery mechanical properties and stresses quantified using in vivo data from normotensive and hypertensive humans. Biomechanics and Modeling in Mechanobiology. 10: 867-82. PMID 21207095 DOI: 10.1007/s10237-010-0279-6  0.68
2010 Niklason LE, Yeh AT, Calle EA, Bai Y, Valentín A, Humphrey JD. Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling. Proceedings of the National Academy of Sciences of the United States of America. 107: 3335-9. PMID 19955446 DOI: 10.1073/pnas.0907813106  0.68
2009 Hu JJ, Humphrey JD, Yeh AT. Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopy. Tissue Engineering. Part A. 15: 1553-64. PMID 19063662 DOI: 10.1089/ten.tea.2008.0287  0.68
2008 Dahl SL, Vaughn ME, Hu JJ, Driessen NJ, Baaijens FP, Humphrey JD, Niklason LE. A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels. Annals of Biomedical Engineering. 36: 1782-92. PMID 18720007 DOI: 10.1007/s10439-008-9554-4  0.68
2008 Masson I, Boutouyrie P, Laurent S, Humphrey JD, Zidi M. Characterization of arterial wall mechanical behavior and stresses from human clinical data. Journal of Biomechanics. 41: 2618-27. PMID 18684458 DOI: 10.1016/j.jbiomech.2008.06.022  0.68
2008 Hu JJ, Ambrus A, Fossum TW, Miller MW, Humphrey JD, Wilson E. Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 56: 359-70. PMID 18071063 DOI: 10.1369/jhc.7A7324.2007  0.68
2008 Alford PW, Humphrey JD, Taber LA. Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents. Biomechanics and Modeling in Mechanobiology. 7: 245-62. PMID 17786493 DOI: 10.1007/s10237-007-0101-2  0.68
2004 Gleason RL, Hu JJ, Humphrey JD. Building a functional artery: issues from the perspective of mechanics. Frontiers in Bioscience : a Journal and Virtual Library. 9: 2045-55. PMID 15353269  0.68
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