☰

Jonathan R. Silva, Ph.D. - Publications

Affiliations: 
2008 Washington University, Saint Louis, St. Louis, MO 
Area:
Biomedical Engineering
Tree Info Similar researchers PubMed Report error

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kang PW, Woodbury L, Angsutararux P, Sambare N, Shi J, Marras M, Abella C, Bedi A, Zinn D, Cui J, Silva JR. Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function. Pnas Nexus. 2: pgad335. PMID 37965565 DOI: 10.1093/pnasnexus/pgad335  0.322
2023 Lesage A, Lorenzini M, Burel S, Sarlandie M, Bibault F, Lindskog C, Maloney D, Silva JR, Townsend RR, Nerbonne JM, Marionneau C. Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse. The Journal of General Physiology. 155. PMID 37516919 DOI: 10.1085/jgp.202213293  0.324
2023 Hanson A, McClenaghan C, Weng KC, Colijn S, Stratman AN, Halabi CM, Grange DK, Silva JR, Nichols CG. Electrophysiology of human iPSC-derived vascular smooth muscle cells and cell autonomous consequences of Cantu Syndrome mutations. Biorxiv : the Preprint Server For Biology. PMID 37425756 DOI: 10.1101/2023.06.29.547088  0.458
2023 Moreno JD, Silva JR. Emerging methods to model cardiac ion channel and myocyte electrophysiology. Biophysics Reviews. 4: 011315. PMID 37034130 DOI: 10.1063/5.0127713  0.338
2023 Angsutararux P, Dutta AK, Marras M, Abella C, Mellor RL, Shi J, Nerbonne JM, Silva JR. Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors. The Journal of General Physiology. 155. PMID 36944081 DOI: 10.1085/jgp.202213300  0.37
2023 Lesage A, Lorenzini M, Burel S, Sarlandie M, Bibault F, Maloney D, Silva JR, Reid Townsend R, Nerbonne JM, Marionneau C. FHF2 phosphorylation and regulation of native myocardial Na 1.5 channels. Biorxiv : the Preprint Server For Biology. PMID 36778222 DOI: 10.1101/2023.01.31.526475  0.331
2023 Kang PW, Woodbury L, Angsutararux P, Sambare N, Shi J, Marras M, Abella C, Bedi A, Zinn D, Cui J, Silva JR. Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function. Biorxiv : the Preprint Server For Biology. PMID 36747728 DOI: 10.1101/2023.01.28.526031  0.361
2022 Ransdell JL, Moreno JD, Bhagavan D, Silva JR, Nerbonne JM. Intrinsic mechanisms in the gating of resurgent Na currents. Elife. 11. PMID 35076394 DOI: 10.7554/eLife.70173  0.382
2021 Angsutararux P, Zhu W, Voelker TL, Silva JR. Molecular Pathology of Sodium Channel Beta-Subunit Variants. Frontiers in Pharmacology. 12: 761275. PMID 34867379 DOI: 10.3389/fphar.2021.761275  0.377
2021 Mangold KE, Wang W, Johnson EK, Bhagavan D, Moreno JD, Nerbonne JM, Silva JR. Identification of structures for ion channel kinetic models. Plos Computational Biology. 17: e1008932. PMID 34398881 DOI: 10.1371/journal.pcbi.1008932  0.525
2021 Angsutararux P, Kang PW, Zhu W, Silva JR. Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation. The Journal of General Physiology. 153. PMID 34347027 DOI: 10.1085/jgp.202112891  0.341
2021 Lorenzini M, Burel S, Lesage A, Wagner E, Charrière C, Chevillard PM, Evrard B, Maloney D, Ruff KM, Pappu RV, Wagner S, Nerbonne JM, Silva JR, Townsend RR, Maier LS, et al. Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. The Journal of General Physiology. 153. PMID 33410863 DOI: 10.1085/jgp.202012646  0.302
2020 Kang PW, Westerlund AM, Shi J, White KM, Dou AK, Cui AH, Silva JR, Delemotte L, Cui J. Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening. Science Advances. 6. PMID 33310856 DOI: 10.1126/sciadv.abd6798  0.342
2020 Zhu W, Li T, Silva JR, Chen J. Conservation and divergence in NaChBac and Na1.7 pharmacology reveals novel drug interaction mechanisms. Scientific Reports. 10: 10730. PMID 32612253 DOI: 10.1038/S41598-020-67761-5  0.463
2020 Angsutararux P, Voelker TL, Malcolm C, Zhu W, Silva JR. Revisiting NaV Channel Inactivation: The Role of Fibroblast Growth Factor Homologous Factor (FHF) Biophysical Journal. 118: 575a. DOI: 10.1016/J.Bpj.2019.11.3126  0.331
2020 Mangold K, Silva JR. Creating Ion Channel Models with Unbiased Graphs Biophysical Journal. 118: 494a. DOI: 10.1016/J.Bpj.2019.11.2732  0.367
2020 Kang PW, Westerlund AM, Shi J, McFarland White K, Dou AK, Silva JR, Delemotte L, Cui J. Calmodulin Functionally Couples the KCNQ1 Channel Voltage-Sensing and Pore Domains Biophysical Journal. 118: 332a-333a. DOI: 10.1016/J.Bpj.2019.11.1857  0.403
2019 Moreno JD, Zhu W, Mangold K, Chung W, Silva JR. A Molecularly Detailed Na1.5 Model Reveals a New Class I Antiarrhythmic Target. Jacc. Basic to Translational Science. 4: 736-751. PMID 31709321 DOI: 10.1016/J.Jacbts.2019.06.002  0.377
2019 Salvage SC, Zhu W, Habib ZF, Hwang SS, Irons JR, Huang CLH, Silva JR, Jackson AP. Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain. The Journal of Biological Chemistry. PMID 31659116 DOI: 10.1074/Jbc.Ra119.010283  0.356
2019 Li B, Silva JR, Lu X, Luo L, Wang Y, Xu L, Aierken A, Shynykul Z, Kamau PM, Luo A, Yang J, Su D, Yang F, Cui J, Yang S, et al. Molecular game theory for a toxin-dominant food chain model National Science Review. 6: 1191-1200. DOI: 10.1093/Nsr/Nwz097  0.318
2019 Mangold K, Silva J. Enumerating Viable N-State Markov Models of Sodium Channel Dynamics Biophysical Journal. 116: 388a. DOI: 10.1016/J.Bpj.2018.11.2103  0.406
2018 Zhu W, Mazzanti A, Voelker T, Hou P, Moreno JD, Angsutararux P, Naegle KM, Priori SG, Silva JR. Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome. Circulation Research. PMID 30566038 DOI: 10.1161/Circresaha.118.314050  0.368
2018 Silva JR. How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels. Biophysical Journal. 114: 259-266. PMID 29401425 DOI: 10.1016/J.Bpj.2017.11.024  0.454
2018 Zhu W, Voelker TL, Moreno JD, Mazzanti A, Priori SG, Silva JR. Molecular Basis of Mexiletine Response Variability in Sodium Channels with Long QT Mutations Biophysical Journal. 114: 636a. DOI: 10.1016/J.Bpj.2017.11.3436  0.367
2018 Moreno J, Zhu W, Silva J. A Computational Model of the Cardiac Sodium Channel DIII Voltage Sensor: Connecting Molecular Movements to Tissue Dynamics Biophysical Journal. 114: 632a-633a. DOI: 10.1016/J.Bpj.2017.11.3418  0.429
2017 Peters CH, Yu A, Zhu W, Silva JR, Ruben PC. Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation. Plos One. 12: e0184605. PMID 28898267 DOI: 10.1371/Journal.Pone.0184605  0.456
2017 Mangold KE, Brumback BD, Angsutararux P, Voelker TL, Zhu W, Kang PW, Moreno J, Silva JR. Mechanisms and Models of Cardiac Sodium Channel Inactivation. Channels (Austin, Tex.). 0. PMID 28837385 DOI: 10.1080/19336950.2017.1369637  0.518
2017 Zhu W, Voelker TL, Varga Z, Schubert AR, Nerbonne JM, Silva JR. Mechanisms of noncovalent β subunit regulation of NaV channel gating. The Journal of General Physiology. PMID 28720590 DOI: 10.1085/Jgp.201711802  0.387
2017 Hsu EJ, Zhu W, Schubert AR, Voelker T, Varga Z, Silva JR. Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains. The Journal of General Physiology. PMID 28232510 DOI: 10.1085/Jgp.201611678  0.452
2016 Teed ZR, Silva JR. A computationally efficient algorithm for fitting ion channel parameters. Methodsx. 3: 577-588. PMID 27924282 DOI: 10.1016/J.Mex.2016.11.001  0.468
2016 Wang HG, Zhu W, Kanter RJ, Silva JR, Honeywell C, Gow RM, Pitt GS. A Novel NaV1.5 Voltage Sensor Mutation Associated with Severe Atrial and Ventricular Arrhythmias. Journal of Molecular and Cellular Cardiology. PMID 26801742 DOI: 10.1016/J.Yjmcc.2016.01.014  0.345
2016 Schubert AR, Zhu W, Silva JR. Class I Anti-Arrhythmics Differentially Regulate Cardiac Sodium Channel Voltage-Sensing Domains Biophysical Journal. 110: 437a-438a. DOI: 10.1016/J.Bpj.2015.11.2359  0.43
2016 Hsu EJ, Zhu W, Varga Z, Schubert AR, Silva JR. DIII of Voltage-Gated Na+ Channels Interacts With Inactivation in the Time Domain of Intermediate Inactivation Biophysical Journal. 110: 437a. DOI: 10.1016/J.Bpj.2015.11.2357  0.367
2015 Zhu W, Varga Z, Silva JR. Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry. Progress in Biophysics and Molecular Biology. PMID 26724572 DOI: 10.1016/J.Pbiomolbio.2015.12.003  0.53
2015 Brettmann JB, Urusova D, Tonelli M, Silva JR, Henzler-Wildman KA. Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621745 DOI: 10.1073/Pnas.1515965112  0.747
2015 Varga Z, Zhu W, Schubert AR, Pardieck JL, Krumholz A, Hsu EJ, Zaydman MA, Cui J, Silva JR. Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation. Arrhythmia and Electrophysiology. PMID 26283144 DOI: 10.1161/Circep.115.003155  0.456
2015 Zhu W, Hsu EJ, Schubert AR, Varga Z, Silva JR. Optical Tracking of Nav1.5 Conformation Reveals Molecular Mechanisms β1 Subunit Regulation Biophysical Journal. 108: 491a. DOI: 10.1016/J.Bpj.2014.11.2685  0.343
2014 Silva JR, Cooper P, Nichols CG. Modeling K,ATP--dependent excitability in pancreatic islets. Biophysical Journal. 107: 2016-26. PMID 25418087 DOI: 10.1016/J.Bpj.2014.09.037  0.745
2014 Silva J. Slow inactivation of Na(+) channels. Handbook of Experimental Pharmacology. 221: 33-49. PMID 24737231 DOI: 10.1007/978-3-642-41588-3_3  0.465
2014 Rudokas MW, Varga Z, Schubert AR, Asaro AB, Silva JR. The Xenopus oocyte cut-open vaseline gap voltage-clamp technique with fluorometry. Journal of Visualized Experiments : Jove. PMID 24637712 DOI: 10.3791/51040  0.442
2014 Zaydman MA, Li Y, Beller Z, Wu D, Rong H, Silva JR, Delaloye K, Shi J, Cohen I, Cui J. Dynamic Pip2-Iks Interactions Mediate Cardiac Rate Adaptation Biophysical Journal. 106: 749a-750a. DOI: 10.1016/J.Bpj.2013.11.4128  0.464
2014 Zaydman MA, Kasimova M, Beller Z, Delaloye K, Shi J, Silva JR, Tarek M, Cui J. State-Dependent Lipid Interactions Couple the Conformations of the Voltage-Sensing and Pore-Gate Domains Biophysical Journal. 106: 742a. DOI: 10.1016/J.Bpj.2013.11.4085  0.392
2014 Varga Z, Schubert AR, Asaro AB, Cui J, Zaydman MA, Nichols CG, Silva JR. Distinct Voltage Sensor Gating of Cardiac NaV Channels Biophysical Journal. 106: 36a-37a. DOI: 10.1016/J.Bpj.2013.11.277  0.619
2013 Zhang HX, Silva JR, Lin YW, Verbsky JW, Lee US, Kanter EM, Yamada KA, Schuessler RB, Nichols CG. Heterogeneity and function of K(ATP) channels in canine hearts. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 1576-83. PMID 23871704 DOI: 10.1016/J.Hrthm.2013.07.020  0.613
2013 Zaydman MA, Silva JR, Delaloye K, Li Y, Liang H, Larsson HP, Shi J, Cui J. Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proceedings of the National Academy of Sciences of the United States of America. 110: 13180-5. PMID 23861489 DOI: 10.1073/Pnas.1305167110  0.428
2013 Silva JR, Goldstein SA. Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology. 141: 323-34. PMID 23401572 DOI: 10.1085/Jgp.201210910  0.64
2013 Silva JR, Goldstein SA. Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: wild-type skeletal muscle Na(V)1.4. The Journal of General Physiology. 141: 309-21. PMID 23401571 DOI: 10.1085/Jgp.201210909  0.65
2013 Asaro AB, Zaydman MA, Wong N, Schubert AR, Rudokas M, Cui J, Nichols CG, Silva JR. Applying Voltage Clamp Fluorometry to Track SCN5A Voltage Sensor Movement Biophysical Journal. 104: 138a. DOI: 10.1016/J.Bpj.2012.11.785  0.607
2013 Zaydman MA, Silva JR, Delaloye K, Shi J, Larsson HP, Cui J. PIP2 is Required to Couple the Voltage-Sensing Domain to the Pore for the Activation of KCNQ1 by Voltage Biophysical Journal. 104: 357a. DOI: 10.1016/J.Bpj.2012.11.1981  0.382
2013 Zhang HX, Silva JR, Nichols CG. Cardiac KATP channels in health and diseases Electrical Diseases of the Heart. 1: 259-279. DOI: 10.1007/978-1-4471-4881-4_16  0.497
2012 Zaydman MA, Silva JR, Cui J. Ion channel associated diseases: overview of molecular mechanisms. Chemical Reviews. 112: 6319-33. PMID 23151230 DOI: 10.1021/Cr300360K  0.308
2012 Zhang H, Silva J, Lin Y, Verbsky J, Lee U, Kanter E, Yamada K, Schuessler R, Nichols C. Heterogeneity and Function of ATP-Sensitive Potassium Channels in Canine Hearts Heart Rhythm. 9: 1917. DOI: 10.1016/J.Hrthm.2012.09.112  0.626
2012 Zaydman MA, Silva JR, Delaloye K, Larsson HP, Cui J. The Role of PIP2 in the Voltage-Dependent Activation of Kv7.1 Biophysical Journal. 102: 331a-332a. DOI: 10.1016/J.Bpj.2011.11.1816  0.447
2011 Silva JR, Golstein SA. Slow Inactivation of Nav Channels Described by Composite Movements of Voltage Sensors in Domains I, II and III Biophysical Journal. 100: 15a. DOI: 10.1016/J.Bpj.2010.12.290  0.416
2010 Silva JR, Rudy Y. Multi-scale electrophysiology modeling: from atom to organ. The Journal of General Physiology. 135: 575-81. PMID 20513759 DOI: 10.1085/Jgp.200910358  0.608
2010 Silva JR, Goldstein SA. Recovery of Voltage-Gated Nav1.4 Channels from Slow Inactivation Reflects Memory of Prior Stimulation in Multiple Molecular Processes Biophysical Journal. 98: 111a. DOI: 10.1016/J.Bpj.2009.12.4197  0.694
2009 Silva JR, Pan H, Wu D, Nekouzadeh A, Decker KF, Cui J, Baker NA, Sept D, Rudy Y. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proceedings of the National Academy of Sciences of the United States of America. 106: 11102-6. PMID 19549851 DOI: 10.1073/Pnas.0904505106  0.766
2009 Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y. Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1017-26. PMID 19168720 DOI: 10.1152/Ajpheart.01216.2008  0.745
2008 Nekouzadeh A, Silva JR, Rudy Y. Modeling subunit cooperativity in opening of tetrameric ion channels. Biophysical Journal. 95: 3510-20. PMID 18621838 DOI: 10.1529/Biophysj.108.136721  0.586
2007 Faber GM, Silva J, Livshitz L, Rudy Y. Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation. Biophysical Journal. 92: 1522-43. PMID 17158566 DOI: 10.1529/Biophysj.106.088807  0.557
2006 Rudy Y, Silva JR. Computational biology in the study of cardiac ion channels and cell electrophysiology. Quarterly Reviews of Biophysics. 39: 57-116. PMID 16848931 DOI: 10.1017/S0033583506004227  0.627
2005 Silva J, Rudy Y. Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation. 112: 1384-91. PMID 16129795 DOI: 10.1161/Circulationaha.105.543306  0.58
2005 Livshitz L, Decker K, Faber G, O'Hara T, Silva J, Rudy Y. Comments on "A model for human ventricular tissue". American Journal of Physiology. Heart and Circulatory Physiology. 288: H453; author reply H. PMID 15598875 DOI: 10.1152/Ajpheart.00826.2004  0.723
2004 O'Hara T, Decker K, Faber G, Livshitz L, Silva J, Rudy Y. Comments on: "Role of individual ionic current systems in ventricular cells hypothesized by a model study" by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003. The Japanese Journal of Physiology. 54: 505-7; author reply . PMID 15667675 DOI: 10.2170/Jjphysiol.54.505  0.714
2003 Silva J, Rudy Y. Mechanism of pacemaking in I(K1)-downregulated myocytes. Circulation Research. 92: 261-3. PMID 12595336 DOI: 10.1161/01.Res.0000057996.20414.C6  0.6
Show low-probability matches.