| Year |
Citation |
Score |
| 2022 |
Kitagawa K, Hamaguchi A, Fukushima K, Nakano Y, Regan JW, Mashimo M, Fujino H. Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells. European Journal of Pharmacology. 920: 174863. PMID 35240193 DOI: 10.1016/j.ejphar.2022.174863 |
0.32 |
|
| 2022 |
Fukushima K, Senoo K, Kurata N, Regan JW, Fujino H. The Gαs-protein-mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors. Febs Open Bio. PMID 35124898 DOI: 10.1002/2211-5463.13378 |
0.487 |
|
| 2021 |
Okura I, Hasuoka N, Senoo K, Suganami A, Fukushima K, Regan JW, Mashimo M, Murayama T, Tamura Y, Fujino H. The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD or PGE. Pharmacological Reports : Pr. PMID 33786738 DOI: 10.1007/s43440-021-00247-x |
0.481 |
|
| 2020 |
Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H. 15-keto-PGEacts as a biased/partial agonist to terminate PGE-evoked signaling. The Journal of Biological Chemistry. PMID 32727851 DOI: 10.1074/Jbc.Ra120.013988 |
0.552 |
|
| 2020 |
Kitagawa K, Hamaguchi A, Mashimo M, Regan JW, Fukushima K, Fujino H. Interleukin-4 may suppress expression of E-type prostanoid receptor4 in human colorectal cancer HCA-7 cells. Proceedings For Annual Meeting of the Japanese Pharmacological Society. 93: 2-P-246. DOI: 10.1254/jpssuppl.93.0_2-p-246 |
0.323 |
|
| 2019 |
Kurata N, Tokashiki N, Fukushima K, Misao T, Hasuoka N, Kitagawa K, Mashimo M, Regan JW, Murayama T, Fujino H. Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. European Journal of Pharmacology. 853: 308-315. PMID 30980797 DOI: 10.1016/J.Ejphar.2019.04.014 |
0.444 |
|
| 2018 |
Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H. Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Pharmacology Research & Perspectives. 6: e00441. PMID 30455960 DOI: 10.1002/Prp2.441 |
0.548 |
|
| 2017 |
Araki Y, Suganami A, Endo S, Masuda Y, Fukushima K, Regan JW, Murayama T, Tamura Y, Fujino H. PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. Febs Letters. PMID 28986997 DOI: 10.1002/1873-3468.12878 |
0.429 |
|
| 2016 |
Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. The Febs Journal. PMID 27636113 DOI: 10.1111/Febs.13899 |
0.576 |
|
| 2015 |
Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T. Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. European Journal of Pharmacology. PMID 26518053 DOI: 10.1016/J.Ejphar.2015.10.044 |
0.565 |
|
| 2015 |
Otake S, Yoshida K, Seira N, Sanchez CM, Regan JW, Fujino H, Murayama T. Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells. Pharmacology Research & Perspectives. 3: e00083. PMID 25692008 DOI: 10.1002/Prp2.83 |
0.544 |
|
| 2014 |
Oyama S, Fujino H, Yamazaki R, Okura I, Regan JW, Awata A, Arai T, Murayama T. A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. Archives of Biochemistry and Biophysics. 541: 21-9. PMID 24239863 DOI: 10.1016/J.Abb.2013.10.023 |
0.459 |
|
| 2013 |
DiSalvo D, Kuzmich D, Bentzien J, Regan J, Kukulka A, Fadra-Khan T, Nelson R, Harcken C, Thomson D, Nabozny G. Substituted phenyl as a steroid A-ring mimetic: providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands. Bioorganic & Medicinal Chemistry Letters. 23: 6645-9. PMID 24239189 DOI: 10.1016/j.bmcl.2013.10.047 |
0.314 |
|
| 2013 |
Yoshida K, Fujino H, Otake S, Seira N, Regan JW, Murayama T. Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. European Journal of Pharmacology. 718: 408-17. PMID 23973650 DOI: 10.1016/J.Ejphar.2013.08.002 |
0.531 |
|
| 2012 |
Ji R, Sanchez CM, Chou CL, Chen XB, Woodward DF, Regan JW. Prostanoid EP₁ receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB. British Journal of Pharmacology. 166: 1033-46. PMID 22188298 DOI: 10.1111/J.1476-5381.2011.01817.X |
0.678 |
|
| 2011 |
Fujino H, Toyomura K, Chen XB, Regan JW, Murayama T. Prostaglandin E₂ regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells. Biochemical Pharmacology. 81: 379-87. PMID 21070749 DOI: 10.1016/J.Bcp.2010.11.001 |
0.483 |
|
| 2011 |
Salinthone S, Schillace RV, Tsang C, Regan JW, Bourdette DN, Carr DW. Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms. The Journal of Nutritional Biochemistry. 22: 681-90. PMID 21036588 DOI: 10.1016/J.Jnutbio.2010.05.008 |
0.414 |
|
| 2010 |
Fujino H, Murayama T, Regan JW. Assessment of constitutive activity in E-type prostanoid receptors. Methods in Enzymology. 484: 95-107. PMID 21036228 DOI: 10.1016/B978-0-12-381298-8.00005-8 |
0.542 |
|
| 2010 |
Chandramouli A, Mercado-Pimentel ME, Hutchinson A, Gibadulinová A, Olson ER, Dickinson S, Shañas R, Davenport J, Owens J, Bhattacharyya AK, Regan JW, Pastorekova S, Arumugam T, Logsdon CD, Nelson MA. The induction of S100p expression by the Prostaglandin E₂ (PGE₂)/EP4 receptor signaling pathway in colon cancer cells. Cancer Biology & Therapy. 10: 1056-66. PMID 20890108 DOI: 10.4161/Cbt.10.10.13373 |
0.543 |
|
| 2010 |
Hutchinson AJ, Coons SC, Chou CL, Xu W, Stamer WD, Woodward DF, Regan JW. Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. Current Eye Research. 35: 408-18. PMID 20450254 DOI: 10.3109/02713680903581021 |
0.451 |
|
| 2010 |
Ji R, Chou CL, Xu W, Chen XB, Woodward DF, Regan JW. EP1 prostanoid receptor coupling to G i/o up-regulates the expression of hypoxia-inducible factor-1 alpha through activation of a phosphoinositide-3 kinase signaling pathway. Molecular Pharmacology. 77: 1025-36. PMID 20335389 DOI: 10.1124/Mol.110.063933 |
0.683 |
|
| 2009 |
Hutchinson AJ, Chou CL, Israel DD, Xu W, Regan JW. Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF. Neurochemistry International. 54: 439-46. PMID 19428786 DOI: 10.1016/J.Neuint.2009.01.018 |
0.742 |
|
| 2009 |
Israel DD, Regan JW. EP(3) prostanoid receptor isoforms utilize distinct mechanisms to regulate ERK 1/2 activation. Biochimica Et Biophysica Acta. 1791: 238-45. PMID 19416642 DOI: 10.1016/J.Bbalip.2009.01.021 |
0.75 |
|
| 2009 |
Xu W, Chou CL, Israel DD, Hutchinson AJ, Regan JW. PGF(2alpha) stimulates FP prostanoid receptor mediated crosstalk between Ras/Raf signaling and Tcf transcriptional activation. Biochemical and Biophysical Research Communications. 381: 625-9. PMID 19248765 DOI: 10.1016/J.Bbrc.2009.02.102 |
0.767 |
|
| 2008 |
Taniguchi T, Fujino H, Israel DD, Regan JW, Murayama T. Human EP3(I) prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression. Biochemical and Biophysical Research Communications. 377: 1173-8. PMID 18996083 DOI: 10.1016/J.Bbrc.2008.10.140 |
0.753 |
|
| 2008 |
Xu W, Chou CL, Sun H, Fujino H, Chen QM, Regan JW. FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade. Molecular Pharmacology. 73: 111-8. PMID 17911534 DOI: 10.1124/Mol.107.038778 |
0.507 |
|
| 2007 |
Cherukuri DP, Chen XB, Goulet AC, Young RN, Han Y, Heimark RL, Regan JW, Meuillet E, Nelson MA. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Experimental Cell Research. 313: 2969-79. PMID 17631291 DOI: 10.1016/J.Yexcr.2007.06.004 |
0.51 |
|
| 2007 |
Fujino H, Chen XB, Regan JW, Murayama T. Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells. Biochemical and Biophysical Research Communications. 359: 568-73. PMID 17555711 DOI: 10.1016/J.Bbrc.2007.05.145 |
0.453 |
|
| 2007 |
Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, ... Regan JW, et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. The Journal of Biological Chemistry. 282: 22254-66. PMID 17519235 DOI: 10.1074/Jbc.M703169200 |
0.375 |
|
| 2007 |
Israel DD, Regan JW. Differential signaling pathway activation and gene regulation among three human prostaglandin E3 (EP3) receptors The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A429 |
0.733 |
|
| 2006 |
Regan J, Lee TW, Zindell RM, Bekkali Y, Bentzien J, Gilmore T, Hammach A, Kirrane TM, Kukulka AJ, Kuzmich D, Nelson RM, Proudfoot JR, Ralph M, Pelletier J, Souza D, et al. Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists. Journal of Medicinal Chemistry. 49: 7887-96. PMID 17181172 DOI: 10.1021/jm061273t |
0.305 |
|
| 2006 |
Chen XB, Regan JW. Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy Cellular and Molecular Life Sciences. 63: 112-121. PMID 16378246 DOI: 10.1007/S00018-005-5303-0 |
0.47 |
|
| 2006 |
Fujino H, Regan JW. EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. Molecular Pharmacology. 69: 5-10. PMID 16204467 DOI: 10.1124/Mol.105.017749 |
0.547 |
|
| 2005 |
Fujino H, Salvi S, Regan JW. Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. Molecular Pharmacology. 68: 251-9. PMID 15855407 DOI: 10.1124/Mol.105.011833 |
0.551 |
|
| 2004 |
Fujino H, Vielhauer GA, Regan JW. Prostaglandin E2 selectively antagonizes prostaglandin F2alpha-stimulated T-cell factor/beta-catenin signaling pathway by the FPB prostanoid receptor. The Journal of Biological Chemistry. 279: 43386-91. PMID 15280380 DOI: 10.1074/Jbc.M408276200 |
0.756 |
|
| 2004 |
Fujino H, Regan JW. Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor. Biochemical and Biophysical Research Communications. 317: 1114-20. PMID 15094384 DOI: 10.1016/J.Bbrc.2004.03.167 |
0.415 |
|
| 2004 |
Vielhauer GA, Fujino H, Regan JW. Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Archives of Biochemistry and Biophysics. 421: 175-85. PMID 14984197 DOI: 10.1016/J.Abb.2003.10.021 |
0.785 |
|
| 2003 |
Regan JW. EP2 and EP4 prostanoid receptor signaling. Life Sciences. 74: 143-53. PMID 14607241 DOI: 10.1016/J.Lfs.2003.09.031 |
0.565 |
|
| 2003 |
Fujino H, Regan JW. Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer? Trends in Pharmacological Sciences. 24: 335-40. PMID 12871665 DOI: 10.1016/S0165-6147(03)00162-7 |
0.535 |
|
| 2003 |
Fujino H, Regan JW. Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor. European Journal of Pharmacology. 465: 39-41. PMID 12650831 DOI: 10.1016/S0014-2999(03)01485-7 |
0.531 |
|
| 2003 |
Fujino H, Xu W, Regan JW. Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. The Journal of Biological Chemistry. 278: 12151-6. PMID 12566441 DOI: 10.1074/Jbc.M212665200 |
0.574 |
|
| 2003 |
Porter AC, Svensson SP, Stamer WD, Bahl JJ, Richman JG, Regan JW. Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. Life Sciences. 72: 1455-66. PMID 12535714 DOI: 10.1016/S0024-3205(02)02381-0 |
0.415 |
|
| 2002 |
Weber TJ, Markillie LM, Chrisler WB, Vielhauer GA, Regan JW. Modulation of JB6 mouse epidermal cell transformation response by the prostaglandin F2alpha receptor. Molecular Carcinogenesis. 35: 163-72. PMID 12489107 DOI: 10.1002/Mc.10079 |
0.768 |
|
| 2002 |
Fujino H, Srinivasan D, Regan JW. Cellular conditioning and activation of beta-catenin signaling by the FPB prostanoid receptor. The Journal of Biological Chemistry. 277: 48786-95. PMID 12368277 DOI: 10.1074/Jbc.M209393200 |
0.628 |
|
| 2002 |
Srinivasan D, Fujino H, Regan JW. Differential internalization of the prostaglandin f(2alpha) receptor isoforms: role of protein kinase C and clathrin. The Journal of Pharmacology and Experimental Therapeutics. 302: 219-24. PMID 12065720 DOI: 10.1124/Jpet.302.1.219 |
0.696 |
|
| 2002 |
Anthony TL, Fujino H, Pierce KL, Yool AJ, Regan JW. Differential regulation of Ca(2+)-dependent Cl- currents by FP prostanoid receptor isoforms in Xenopus oocytes. Biochemical Pharmacology. 63: 1797-806. PMID 12034364 DOI: 10.1016/S0006-2952(02)00953-X |
0.507 |
|
| 2002 |
Huang Y, Stamer WD, Anthony TL, Kumar DV, St John PA, Regan JW. Expression of alpha(2)-adrenergic receptor subtypes in prenatal rat spinal cord. Brain Research. Developmental Brain Research. 133: 93-104. PMID 11882340 DOI: 10.1016/S0165-3806(02)00275-4 |
0.348 |
|
| 2002 |
Fujino H, West KA, Regan JW. Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. The Journal of Biological Chemistry. 277: 2614-9. PMID 11706038 DOI: 10.1074/Jbc.M109440200 |
0.526 |
|
| 2001 |
Thompson EJ, Gupta A, Vielhauer GA, Regan JW, Bowden GT. The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. Neoplasia (New York, N.Y.). 3: 402-10. PMID 11687951 DOI: 10.1038/Sj.Neo.7900182 |
0.729 |
|
| 2001 |
Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. The Journal of Biological Chemistry. 276: 42063-9. PMID 11533056 DOI: 10.1074/Jbc.M105348200 |
0.473 |
|
| 2001 |
Fujino H, Regan JW. FP Prostanoid Receptor Activation of a T-cell Factor/β-Catenin Signaling Pathway Journal of Biological Chemistry. 276: 12489-12492. PMID 11278257 DOI: 10.1074/Jbc.C100039200 |
0.516 |
|
| 2000 |
Woodward DF, Krauss AH, Chen J, Gil DW, Kedzie KM, Protzman CE, Shi L, Chen R, Krauss HA, Bogardus A, Dinh HT, Wheeler LA, Andrews SW, Burk RM, Gac T, ... ... Regan JW, et al. Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. British Journal of Pharmacology. 130: 1933-43. PMID 10952685 DOI: 10.1038/Sj.Bjp.0703462 |
0.424 |
|
| 2000 |
Fujino H, Pierce KL, Srinivasan D, Protzman CE, Krauss AH, Woodward DF, Regan JW. Delayed reversal of shape change in cells expressing FP(B) prostanoid receptors. Possible role of receptor resensitization. The Journal of Biological Chemistry. 275: 29907-14. PMID 10893233 DOI: 10.1074/Jbc.M003467200 |
0.686 |
|
| 2000 |
Anthony TL, Pierce KL, Regan JW. Characterization of ep prostanoid receptor subtypes in primary cultures of bovine ciliary epithelial cells by immunofluorescent microscopy and functional studies. Current Eye Research. 20: 394-404. PMID 10855034 DOI: 10.1076/0271-3683(200005)2051-1Ft394 |
0.524 |
|
| 2000 |
Fujino H, Srinivasan D, Pierce KL, Regan JW. Differential regulation of prostaglandin F(2alpha) receptor isoforms by protein kinase C. Molecular Pharmacology. 57: 353-8. PMID 10648645 |
0.647 |
|
| 1999 |
Pierce KL, Fujino H, Srinivasan D, Regan JW. Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton. The Journal of Biological Chemistry. 274: 35944-9. PMID 10585482 DOI: 10.1074/Jbc.274.50.35944 |
0.691 |
|
| 1999 |
Fraeyman N, Vanscheeuwijck P, Wang JM, Huang Y, De Potter WP, Regan JW. Changes in the expression of a2-adrenergic receptor subtypes during maturation of neuronal cells from fetal pig superior cervical ganglia Developmental Brain Research. 116: 127-132. PMID 10521556 DOI: 10.1016/S0165-3806(99)00078-4 |
0.384 |
|
| 1999 |
Hoyer PB, Marion SL, Stine I, Rueda BR, Hamernik DL, Regan JW, Wise ME. Ovine prostaglandin F2alpha receptor: steroid influence on steady-state levels of luteal mRNA. Endocrine. 10: 105-11. PMID 10451218 DOI: 10.1385/Endo:10:2:105 |
0.489 |
|
| 1998 |
Kedzie KM, Donello JE, Krauss HA, Regan JW, Gil DW. A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs Molecular Pharmacology. 54: 584-590. PMID 9730918 DOI: 10.1124/Mol.54.3.584 |
0.542 |
|
| 1998 |
Pierce KL, Regan JW. Prostanoid receptor heterogeneity through alternative mRNA splicing. Life Sciences. 62: 1479-83. PMID 9585122 DOI: 10.1016/S0024-3205(98)00093-9 |
0.579 |
|
| 1998 |
Richman JG, Regan JW. α2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells American Journal of Physiology - Cell Physiology. 274: C654-C662. PMID 9530096 DOI: 10.1152/Ajpcell.1998.274.3.C654 |
0.422 |
|
| 1998 |
Anthony TL, Pierce KL, Stamer WD, Regan JW. Prostaglandin F2 alpha receptors in the human trabecular meshwork. Investigative Ophthalmology & Visual Science. 39: 315-21. PMID 9477988 |
0.347 |
|
| 1998 |
Regan JW, Richman JG. α2-Adrenergic receptors stimulate cell migration and decrease cytoskeletal organization in rat aortic smooth muscle cells Faseb Journal. 12: A700. |
0.304 |
|
| 1997 |
LeVan TD, Dow SB, Chase PB, Bloom JW, Regan JW, Cunningham E, Halonen M. Evidence for platelet-activating factor receptor subtypes on human polymorphonuclear leukocyte membranes. Biochemical Pharmacology. 54: 1007-12. PMID 9374421 DOI: 10.1016/S0006-2952(97)00249-9 |
0.539 |
|
| 1997 |
Svensson SPS, Porter AC, Regan JW. Cloning and functional expression of guinea pig atrial α2-adrenergic receptor subtypes Annals of the New York Academy of Sciences. 812: 171-173. PMID 9186732 DOI: 10.1111/J.1749-6632.1997.Tb48162.X |
0.505 |
|
| 1997 |
Woodward DF, Regan JW, Lake S, Ocklind A. The molecular biology and ocular distribution of prostanoid receptors Survey of Ophthalmology. 41: S15-S21. PMID 9154272 DOI: 10.1016/S0039-6257(97)80003-3 |
0.556 |
|
| 1997 |
Pierce KL, Bailey TJ, Hoyer PB, Gil DW, Woodward DF, Regan JW. Cloning of a carboxyl-terminal isoform of the prostanoid FP receptor. The Journal of Biological Chemistry. 272: 883-7. PMID 8995377 DOI: 10.1074/Jbc.272.2.883 |
0.457 |
|
| 1996 |
Chase PB, Yang JM, Thompson FH, Halonen M, Regan JW. Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization. Cytogenetics and Cell Genetics. 72: 205-7. PMID 8978777 DOI: 10.1159/000134190 |
0.401 |
|
| 1996 |
Stamer WD, Huang Y, Seftor RE, Svensson SS, Snyder RW, Regan JW. Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. Investigative Ophthalmology & Visual Science. 37: 2426-33. PMID 8933759 |
0.365 |
|
| 1996 |
Svensson SPS, Bailey TJ, Porter AC, Richman JG, Regan JW. Heterologous expression of the cloned guinea pig α2A, α2B, and α2C adrenoceptor subtypes: Radioligand binding and functional coupling to a cAMP-responsive reporter gene Biochemical Pharmacology. 51: 291-300. PMID 8573196 DOI: 10.1016/0006-2952(95)02179-5 |
0.426 |
|
| 1996 |
Pierce KL, Yool AJ, Moyer PB, Gil DW, Woodward DE, Regan JW. Cloning of a novel isoform of the sheep FP prostaglandin receptor Proceedings of the Western Pharmacology Society. 39: 104. |
0.475 |
|
| 1995 |
Stamer WD, Seftor RE, Snyder RW, Regan JW. Cultured human trabecular meshwork cells express aquaporin-1 water channels. Current Eye Research. 14: 1095-1100. PMID 8974838 DOI: 10.3109/02713689508995815 |
0.3 |
|
| 1995 |
Woodward DF, Bogardus AM, Donello JE, Fairbairn CE, Gil DW, Kedzie KM, Burke JA, Kharlamb A, Runde E, Andrews SW, Pierce KL, Regan JW. Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor Journal of Ocular Pharmacology and Therapeutics. 11: 447-454. PMID 8590276 |
0.506 |
|
| 1995 |
Burkey TH, Regan JW. Activation of Mitogen-Activated Protein Kinase by the Human Prostaglandin EP3A Receptor Biochemical and Biophysical Research Communications. 211: 152-158. PMID 7779081 DOI: 10.1006/Bbrc.1995.1790 |
0.437 |
|
| 1995 |
Graves PE, Pierce KL, Bailey TJ, Rueda BR, Gil DW, Woodward DF, Yool AJ, Hoyer PB, Regan JW. Cloning of a receptor for prostaglandin F2 alpha from the ovine corpus luteum. Endocrinology. 136: 3430-6. PMID 7628379 DOI: 10.1210/Endo.136.8.7628379 |
0.513 |
|
| 1995 |
Bylund DB, Regan JW, Faber JE, Hieble JP, Triggle CR, Ruffolo RR. Vascular alpha-adrenoceptors: from the gene to the human. Canadian Journal of Physiology and Pharmacology. 73: 533-43. PMID 7585318 DOI: 10.1139/y95-068 |
0.34 |
|
| 1995 |
Woodward DF, Pepperl DJ, Burkey TH, Regan JW. 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist Biochemical Pharmacology. 50: 1731-1733. PMID 7503778 DOI: 10.1016/0006-2952(95)02035-7 |
0.56 |
|
| 1995 |
Huang Y, Gil DW, Vanscheeuwijck P, Stamer WD, Regan JW. Localization of alpha 2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies. Investigative Ophthalmology & Visual Science. 36: 2729-39. PMID 7499095 |
0.344 |
|
| 1995 |
Pierce KL, Gil DW, Woodward DF, Regan JW. Cloning of human prostanoid receptors. Trends in Pharmacological Sciences. 16: 253-6. PMID 7482980 DOI: 10.1016/S0165-6147(00)89035-5 |
0.533 |
|
| 1994 |
Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Molecular Pharmacology. 46: 213-20. PMID 8078484 |
0.484 |
|
| 1994 |
Regan JW, Bailey TJ, Donello JE, Pierce KL, Pepperl DJ, Zhang D, Kedzie KM, Fairbairn CE, Bogardus AM, Woodward DF. Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini. British Journal of Pharmacology. 112: 377-85. PMID 8075855 DOI: 10.1111/J.1476-5381.1994.Tb13082.X |
0.522 |
|
| 1994 |
Chase PB, Regan JW, Halonen M. Evidence for an intron in the 5'-untranslated region of a human PAF receptor gene Journal of Lipid Mediators and Cell Signalling. 10: 81-82. |
0.364 |
|
| 1993 |
Chase PB, Halonen M, Regan JW. Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. American Journal of Respiratory Cell and Molecular Biology. 8: 240-4. PMID 8383507 DOI: 10.1165/Ajrcmb/8.3.240 |
0.416 |
|
| 1993 |
Vanscheeuwijck P, Huang Y, Schullery D, Regan JW. Antibodies to a Human α2-C10 Adrenergic Receptor Fusion Protein Confirm the Cytoplasmic Orientation of the V-VI Loop Biochemical and Biophysical Research Communications. 190: 340-346. PMID 8381272 DOI: 10.1006/Bbrc.1993.1053 |
0.456 |
|
| 1993 |
Pepperl DJ, Regan JW. Selective coupling of α2-adrenergic receptor subtypes to cyclic AMP-dependent reporter gene expression in transiently transfected JEG-3 cells Molecular Pharmacology. 44: 802-809. PMID 8232231 |
0.382 |
|
| 1993 |
Svensson SPS, Bailey TJ, Pepperl DJ, Grundstrom N, Ala-Uotila S, Scheinin M, Karlsson JOG, Regan JW. Cloning and expression of a fish α2-adrenoceptor British Journal of Pharmacology. 110: 54-60. PMID 7693288 DOI: 10.1111/J.1476-5381.1993.Tb13771.X |
0.574 |
|
| 1992 |
Perälä M, Hirvonen H, Kalimo H, Ala-Uotila S, Regan JW, Akerman KE, Scheinin M. Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues. Brain Research. Molecular Brain Research. 16: 57-63. PMID 1334200 DOI: 10.1016/0169-328X(92)90193-F |
0.613 |
|
| 1992 |
Marjamäki A, Ala-Uotila S, Luomala K, Perälä M, Jansson C, Jalkanen M, Regan JW, Scheinin M. Stable expression of recombinant human α2-adrenoceptor subtypes in two mammalian cell lines: characterization with [3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay Bba - Molecular Cell Research. 1134: 169-177. PMID 1313304 DOI: 10.1016/0167-4889(92)90041-9 |
0.652 |
|
| 1991 |
Kurose H, Regan JW, Caron MG, Lefkowitz RJ. Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry. 30: 3335-41. PMID 1849000 DOI: 10.1021/Bi00227A024 |
0.749 |
|
| 1991 |
Maze M, Regan JW. Role of signal transduction in anesthetic action. α2 adrenergic agonists Annals of the New York Academy of Sciences. 625: 409-422. PMID 1711813 DOI: 10.1111/J.1749-6632.1991.Tb33868.X |
0.418 |
|
| 1991 |
Parola AL, Stump DG, Pepperl DJ, Krueger KE, Regan JW, Laird HE. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. The Journal of Biological Chemistry. 266: 14082-7. PMID 1649835 |
0.307 |
|
| 1991 |
Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the β-adrenergic receptor kinase and rhodopsin kinase Biochemistry®. 30: 5118-5125. PMID 1645191 DOI: 10.1021/Bi00235A002 |
0.681 |
|
| 1990 |
Lorenz W, Lomasney JW, Collins S, Regan JW, Caron MG, Lefkowitz RJ. Expression of three α2-adrenergic receptor subtypes in rat tissues: Implications for α2 receptor classification Molecular Pharmacology. 38: 599-603. PMID 2172770 |
0.403 |
|
| 1990 |
Lomasney JW, Lorenz W, Allen LF, Klng K, Regan JW, Yang-Fengh TL, Caron MG, Lefkowitz RJ. Expansion of the α2-adrenergic receptor family: Cloning and characterization of a human α2-adrenergic receptor subtype, the gene for which is located on chromosome 2 Proceedings of the National Academy of Sciences of the United States of America. 87: 5094-5098. PMID 2164221 DOI: 10.1073/Pnas.87.13.5094 |
0.797 |
|
| 1990 |
Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors. Molecular Pharmacology. 37: 65-8. PMID 2153910 |
0.386 |
|
| 1990 |
Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, Regan JW. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. The Journal of Biological Chemistry. 265: 63-9. PMID 2152928 |
0.677 |
|
| 1990 |
Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. Cell Regulation. 1: 445-51. PMID 1981685 DOI: 10.1091/Mbc.1.6.445 |
0.758 |
|
| 1990 |
Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene Molecular Biology of the Cell. 1: 445-451. |
0.552 |
|
| 1989 |
Hoehe MR, Berrettini WH, Regan JW. A biallelic RFLP of the human α2-C4 adrenergic receptor gene (ADRA2RL2) localized on the short arm of chromosome 4 and encoding the putative α2B receptor is identified with Bsu 36 I, using a 1.5 kb probe (p ADRA2RL2) Nucleic Acids Research. 17: 10148. PMID 2574850 DOI: 10.1093/Nar/17.23.10148 |
0.488 |
|
| 1989 |
Fargin A, Raymond JR, Regan JW, Cotecchia S, Lefkowitz RJ, Caron MG. Effector coupling mechanisms of the cloned 5-HT1A receptor Journal of Biological Chemistry. 264: 14848-14852. PMID 2549039 |
0.417 |
|
| 1989 |
Matsui H, Lefkowitz RJ, Caron MG, Regan JW. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor Biochemistry. 28: 4125-4130. PMID 2546589 DOI: 10.1021/Bi00435A075 |
0.774 |
|
| 1989 |
Catterall WA, Kobilka BK, Kobilka TS, Daniels KW, Regan JW, Caran MG, Lefkowitz RJ. Analysis of ligand binding specificity of receptor chimeras Science. 243: 236-237. PMID 2536189 DOI: 10.1126/SCIENCE.2536189 |
0.569 |
|
| 1989 |
Raymond JR, Fargin A, Lohse MJ, Regan JW, Senogles SE, Lefkowitz RJ, Caron MG. Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. Molecular Pharmacology. 36: 15-21. PMID 2526292 |
0.57 |
|
| 1989 |
Kobilka BK, Kobilka TS, Daniels KW, Regan JW, Caran MG, Lefkowitz RJ. Response:Analysis of ligand binding specificity of receptor chimeras Science. 243: 237-237. DOI: 10.1126/Science.243.4888.237 |
0.671 |
|
| 1989 |
Matsui H, Lefkowitz RJ, Caron MG, Regan JW. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet .alpha.2-adrenergic receptor [Erratum to document cited in CA110(21):187980z] Biochemistry. 28: 5702-5702. DOI: 10.1021/Bi00439A054 |
0.748 |
|
| 1989 |
Caron MG, Kobilka BK, Bouvier M, Hausdorff WP, Benovic JL, Lohse M, Cotecchia S, Regan JW, Fargin A, Raymond JR, Lefkowitz RJ. Catecholamine Receptors: Structure, Function, and Regulation Recent Progress in Hormone Research. 48: 195-200. DOI: 10.1007/978-3-642-75022-9_21 |
0.774 |
|
| 1988 |
Lefkowitz RJ, Kobilka BK, Benovic JL, Bouvier M, Cotecchia S, Hausdorff WP, Dohlman HG, Regan JW, Caron MG. Molecular biology of adrenergic receptors. Cold Spring Harbor Symposia On Quantitative Biology. 53: 507-14. PMID 2855490 DOI: 10.1101/Sqb.1988.053.01.058 |
0.797 |
|
| 1988 |
O'Dowd BF, Hnatowich M, Regan JW, Leader WM, Caron MG, Lefkowitz RJ. Site-directed mutagenesis of the cytoplasmic domains of the human β2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling Journal of Biological Chemistry. 263: 15985-15992. PMID 2846532 |
0.442 |
|
| 1988 |
Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proceedings of the National Academy of Sciences of the United States of America. 85: 6301-5. PMID 2842764 DOI: 10.1073/Pnas.85.17.6301 |
0.776 |
|
| 1988 |
Kobilka BK, Kobilka TS, Daniel K, Regan JW, Caron MG, Lefkowitz RJ. Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (New York, N.Y.). 240: 1310-6. PMID 2836950 DOI: 10.1126/Science.2836950 |
0.766 |
|
| 1987 |
Benovic JL, Regan JW, Matsui H, Mayor F, Cotecchia S, Leeb-Lundberg LMF, Caron MG, Lefkowitz RJ. Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase Journal of Biological Chemistry. 262: 17251-17253. PMID 2826414 |
0.709 |
|
| 1987 |
Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (New York, N.Y.). 238: 650-6. PMID 2823383 DOI: 10.1126/Science.2823383 |
0.813 |
|
| 1986 |
Hiroyasu N, Regan JW, Lefkowitz RJ. Chemical modification of α2-adrenoceptors. Possible role for tyrosine in the ligand binding site Biochemical Pharmacology. 35: 4089-4094. PMID 3022750 DOI: 10.1016/0006-2952(86)90033-X |
0.573 |
|
| 1986 |
Regan JW, Raymond JR, Lefkowitz RJ, DeMarinis RM. Photoaffinity labeling of human platelet and rabbit kidney α2-adrenoceptors with [3H]SKF 102229 Biochemical and Biophysical Research Communications. 137: 606-613. PMID 3015124 DOI: 10.1016/0006-291X(86)91121-6 |
0.482 |
|
| 1986 |
Lomasney JW, Leeb-Lundberg LMF, Cotecchia S, Regan JW, DeBernardis JF, Caron MG, Lefkowitz RJ. Mammalian α1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit Journal of Biological Chemistry. 261: 7710-7716. PMID 3011796 |
0.439 |
|
| 1986 |
Cerione RA, Regan JW, Nakata H, Codina J, Benovic JL, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Lefkowitz RJ. Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. The Journal of Biological Chemistry. 261: 3901-9. PMID 3005307 |
0.394 |
|
| 1986 |
Regan JW, Nakata H, DeMarinis RM, Caron MG, Lefkowitz RJ. Purification and characterization of the human platelet α2-adrenergic receptor Journal of Biological Chemistry. 261: 3894-3900. PMID 3005306 |
0.439 |
|
| 1985 |
Regan JW, DeMarinis RM, Lefkowitz RJ. Arylazide photoaffinity probe for α2-adrenoceptors Biochemical Pharmacology. 34: 3667-3672. PMID 2864929 DOI: 10.1016/0006-2952(85)90228-X |
0.515 |
|
| 1984 |
DeMarinis RM, Krog AJ, Shah DH, Lafferty J, Holden KG, Hieble JP, Matthews WD, Regan JW, Lefkowitz RJ, Caron MG. Development of an affinity ligand for purification of α2-adrenoceptors from human platelet membranes Journal of Medicinal Chemistry. 27: 918-921. PMID 6330361 DOI: 10.1002/Chin.198448242 |
0.646 |
|
| 1984 |
Regan JW, DeMarinis RM, Caron MG, Lefkowitz RJ. Identification of the subunit-binding site of α2-adrenergic receptors using [3H]phenoxybenzamine Journal of Biological Chemistry. 259: 7864-7869. PMID 6330087 |
0.437 |
|
| 1984 |
DeMarinis R, Krog A, Shah D, Lafferty J, Holden K, Hieble J, Matthews W, Regan J, Lefkowitz R, Caron M. Additions and Corrections-Development of an Affinity Ligand for Purification of Adrenoceptors from Human Platelet Membranes Journal of Medicinal Chemistry. 27: 1753-1753. DOI: 10.1021/Jm00378A603 |
0.582 |
|
| 1982 |
Regan JW, Barden N, Lefkowitz RJ, Caron MG, DeMarinis RM, Krog AJ, Holden KG, Matthews WD, Hieble JP. Affinity chromatography of human platelet α 2-adrenergic receptors Proceedings of the National Academy of Sciences of the United States of America. 79: 7223-7227. PMID 6130523 DOI: 10.1073/Pnas.79.23.7223 |
0.69 |
|
| 1980 |
Regan JW, Roeske WR, Yamamura HI. 3H-flunitrazepam binding to bovine retina and the effect of GABA thereon Neuropharmacology. 19: 413-414. PMID 6104311 DOI: 10.1016/0028-3908(80)90195-1 |
0.369 |
|
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